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https://www.readbyqxmd.com/read/28418317/no-such-thing-as-chronic-q-fever
#1
Matthieu Million, Didier Raoult
Modern diagnostic methods enable clinicians to look beyond a diagnosis of chronic Q fever and discern whether patients instead have persistent focalized Coxiella burnetii infection(s). Use of these methods and development of criteria to define and treat such infections, especially cardiovascular infections, will improve the prognosis for patients previously thought to have chronic Q fever.
May 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28403908/permissiveness-of-bovine-epithelial-cells-from-lung-intestine-placenta-and-udder-for-infection-with-coxiella-burnetii
#2
Katharina Sobotta, Katharina Bonkowski, Elisabeth Liebler-Tenorio, Pierre Germon, Pascal Rainard, Nina Hambruch, Christiane Pfarrer, Ilse D Jacobsen, Christian Menge
Ruminants are the main source of human infections with the obligate intracellular bacterium Coxiella (C.) burnetii. Infected animals shed high numbers of C. burnetii by milk, feces, and birth products. In goats, shedding by the latter route coincides with C. burnetii replication in epithelial (trophoblast) cells of the placenta, which led us to hypothesize that epithelial cells are generally implicated in replication and shedding of C. burnetii. We therefore aimed at analyzing the interactions of C. burnetii with epithelial cells of the bovine host (1) at the entry site (lung epithelium) which govern host immune responses and (2) in epithelial cells of gut, udder and placenta decisive for the quantity of pathogen excretion...
April 12, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28403767/tick-borne-infectious-diseases-in-australia
#3
REVIEW
Stephen R Graves, John Stenos
Tick bites in Australia can lead to a variety of illnesses in patients. These include infection, allergies, paralysis, autoimmune disease, post-infection fatigue and Australian multisystem disorder. Rickettsial (Rickettsia spp.) infections (Queensland tick typhus, Flinders Island spotted fever and Australian spotted fever) and Q fever (Coxiella burnetii) are the only systemic bacterial infections that are known to be transmitted by tick bites in Australia. Three species of local ticks transmit bacterial infection following a tick bite: the paralysis tick (Ixodes holocyclus) is endemic on the east coast of Australia and causes Queensland tick typhus due to R...
April 17, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28396496/coxiella-burnetii-antibody-seropositivity-is-not-a-risk-factor-for-aids-related-non-hodgkin-lymphoma
#4
Halie K Miller, Loredana Santo, M Constanza Camargo, Cheryl A Winkler, James J Goedert, Gilbert J Kersh, Charles S Rabkin
No abstract text is available yet for this article.
April 10, 2017: Blood
https://www.readbyqxmd.com/read/28394892/acute-q-fever-in-febrile-patients-in-northwestern-of-iran
#5
Saber Esmaeili, Farhad Golzar, Erfan Ayubi, Behrooz Naghili, Ehsan Mostafavi
BACKGROUND: Q fever is an endemic disease in different parts of Iran. This study aimed to investigate the prevalence of acute Q fever disease among at-risk individuals in northwestern Iran. METHODOLOGY: An etiological study was carried out in 2013 in Tabriz County. A total of 116 individuals who were in contact with livestock and had a nonspecific febrile illness were enrolled in the study. IgG phase II antibodies against Coxiella burnetii were detected using ELISA...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28394889/seroprevalence-of-q-fever-among-human-and-animal-in-iran-a-systematic-review-and-meta-analysis
#6
Ashraf Mohabbati Mobarez, Fahimeh Bagheri Amiri, Saber Esmaeili
BACKGROUND: Q fever is a main zoonotic disease around the world. The aim of this meta-analysis was to estimate the overall seroprevalence of Coxiella burnetii among human and animal population in Iran. METHODS: Major national and international databases were searched from 2005 up to August 2016. We extracted the prevalence of Q fever antibodies (IgG) as the main primary outcome. We reported the prevalence of the seropositivity as point and 95% confidence intervals...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28387835/coxiella-burnetii-isolates-originating-from-infected-cattle-induce-a-more-pronounced-pro-inflammatory-cytokine-response-compared-to-isolates-from-infected-goats-and-sheep
#7
Anne Ammerdorffer, Runa Kuley, Annemieke Dinkla, Leo A B Joosten, Rudolf Toman, Hendrik-Jan Roest, Tom Sprong, Johanna M Rebel
Coxiella burnetii is the causative agent of Q fever. Although the prevalence of C. burnetii in cattle is much higher than in goats and sheep, infected cattle are rarely associated with human outbreaks. We investigated whether the immune response of humans differs after contact with C. burnetii isolates from different host origins or with different multi-locus variable number of tandem repeat analysis (MLVA) genotypes.Cytokine responses were measured in human peripheral blood mononuclear cells (PBMCs) stimulated with 16 C...
April 6, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28378988/serological-evidence-of-exposure-to-zoonotic-tick-borne-bacteria-in-pheasants-phasianus-colchicus
#8
Valentina Virginia Ebani, Fabrizio Bertelloni, Paolo Mani
INTRODUCTION AND OBJECTIVE: Previous studies on tick-borne pathogens in the avian population have focused mainly on the detection of the agents in ticks collected from birds, but data about the presence of tick-borne bacteria in these animals are scant. The aim of the presented study was to verify the exposure to some zoonotic tick-borne bacteria, in particular, Anaplasma phagocytophilum, Borrelia burgdorferi sensu lato, Coxiella burnetii, and the Rickettsia species of the Spotted Fever Group (SFG), in pheasants (Phasianus colchicus) living in a central Italy area, characterized by conditions favourable for the diffusion of the ticks...
March 22, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28373734/prevalence-and-risk-factors-for-coxiella-burnetii-seropositivity-in-small-ruminant-veterinarians-and-veterinary-students-in-ontario-canada
#9
Shannon L Meadows, Andria Jones-Bitton, Scott A McEwen, Jocelyn Jansen, Samir N Patel, Catherine Filejski, Paula Menzies
Coxiella burnetii is a zoonotic pathogen that causes Q fever in humans. Serological and questionnaire data on C. burnetii were obtained from 32 small ruminant veterinarians and veterinary students in Ontario, Canada, in February 2012. Overall, 59% of participants were seropositive; advanced stage of career and increased age were associated with seropositivity.
April 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28372886/laboratory-approach-to-the-diagnosis-of-culture-negative-infective-endocarditis
#10
REVIEW
S Subedi, Z Jennings, S C-A Chen
Blood-culture negative endocarditis (BCNE) accounts for up to 35% of all cases of infective endocarditis (IE) and is a serious life-threatening condition with considerable morbidity and mortality. Rapid detection and identification of the causative pathogen is essential for timely, directed therapy. Blood-culture negative endocarditis presents a diagnostic and therapeutic challenge. Causes of BCNE are varied including: treatment with antibiotic agents prior to blood culture collection; sub-optimal specimen collection; and/or infection due to fastidious (eg...
March 16, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28364833/peripartum-dynamics-of-coxiella-burnetii-infections-in-intensively-managed-dairy-goats-associated-with-a-q-fever-outbreak-in-australia
#11
Michael Muleme, John Stenos, Gemma Vincent, Colin R Wilks, Joanne M Devlin, Angus Campbell, Alexander Cameron, Mark A Stevenson, Stephen Graves, Simon M Firestone
Coxiella burnetii may cause reproduction disorders in pregnant animals but subclinical infection in other animals. Unrecognised disease may delay implementation of control interventions, resulting in transmission of infection to other livestock and to humans. Seroreactivity to C. burnetii phase-specific antigens, is routinely used to interpret the course of human Q fever. This approach could be similarly useful in identifying new and existing infections in livestock herds to help describe risk factors or production losses associated with the infections and the implementation of disease-control interventions...
April 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28364266/a-study-on-some-reproductive-disorders-in-dromedary-camel-herds-in-saudi-arabia-with-special-references-to-uterine-infections-and-abortion
#12
Abdelmalik I Khalafalla, Marzook M Al Eknah, Mahmoud Abdelaziz, Ibrahim M Ghoneim
Dromedary camels complaining from conception failure or abortion were investigated and their herders interviewed in Al Ahsa province, Kingdom of Saudi Arabia (KSA) during 2013 and 2015. The most important reproductive disorder according to the responders is uterine infection (60.2%) followed by obesity (22.3%) then physiological conditions (hormonal disturbances; 7.8%), adhesions (3.9%) and repeat breeders (2.9%). Of the camel herders, 78.6% reported previous occurrence of abortion in their herds and 46% reported abortion cases in the last season (2015/2016), while 21...
March 31, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28362816/livestock-associated-risk-factors-for-pneumonia-in-an-area-of-intensive-animal-farming-in-the-netherlands
#13
Gudrun S Freidl, Ineke T Spruijt, Floor Borlée, Lidwien A M Smit, Arianne B van Gageldonk-Lafeber, Dick J J Heederik, Joris Yzermans, Christel E van Dijk, Catharina B M Maassen, Wim van der Hoek
Previous research conducted in 2009 found a significant positive association between pneumonia in humans and living close to goat and poultry farms. However, as this result might have been affected by a large goat-related Q fever epidemic, the aim of the current study was to re-evaluate this association, now that the Q-fever epidemic had ended. In 2014/15, 2,494 adults (aged 20-72 years) living in a livestock-dense area in the Netherlands participated in a medical examination and completed a questionnaire on respiratory health, lifestyle and other items...
2017: PloS One
https://www.readbyqxmd.com/read/28348863/massive-dispersal-of-coxiella-burnetii-among-cattle-across-the-united-states
#14
Sonora Olivas, Heidie Hornstra, Rachael A Priestley, Emily Kaufman, Crystal Hepp, Derek L Sonderegger, Karthik Handady, Robert F Massung, Paul Keim, Gilbert J Kersh, Talima Pearson
Q-fever is an underreported disease caused by the bacterium Coxiella burnetii, which is highly infectious and has the ability to disperse great distances. It is a completely clonal pathogen with low genetic diversity and requires whole-genome analysis to identify discriminating features among closely related isolates. C. burnetii, and in particular one genotype (ST20), is commonly found in cow's milk across the entire dairy industry of the USA. This single genotype dominance is suggestive of host-specific adaptation, rapid dispersal and persistence within cattle...
August 2016: Microbial Genomics
https://www.readbyqxmd.com/read/28340608/molecular-evidence-of-rickettsia-spp-in-ixodid-ticks-and-rodents-in-suburban-natural-and-rural-habitats-in-slovakia
#15
Lenka Minichová, Zuzana Hamšíková, Lenka Mahríková, Mirko Slovák, Elena Kocianová, Mária Kazimírová, Ľudovít Škultéty, Katarína Štefanidesová, Eva Špitalská
BACKGROUND: Natural foci of tick-borne spotted fever group (SFG) rickettsiae of public health concern have been found in Slovakia, but the role of rodents in their circulation is unclear. Ticks (Ixodes ricinus, Ixodes trianguliceps, Dermacentor marginatus, Dermacentor reticulatus, Haemaphysalis concinna and Haemaphysalis inermis) and tissues of rodents (Apodemus flavicollis, Apodemus sylvaticus, Myodes glareolus, Microtus arvalis, Microtus subterraneus and Micromys minutus) were examined for the presence of SFG rickettsiae and Coxiella burnetii by molecular methods...
March 24, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28328183/seroprevalence-of-bartonella-species-coxiella-burnetii-and-toxoplasma-gondii-among-patients-with-hematological-malignancies-a-pilot-study-in-romania
#16
C J Messinger, E S Gurzau, E B Breitschwerdt, C I Tomuleasa, S J Trufan, M M Flonta, R G Maggi, I Berindan-Neagoe, P M Rabinowitz
Patients receiving immunosuppressive cancer treatments in settings where there is a high degree of human-animal interaction may be at increased risk for opportunistic zoonotic infections or reactivation of latent infections. We sought to determine the seroprevalence of selected zoonotic pathogens among patients diagnosed with haematologic malignancies and undergoing chemotherapeutic treatments in Romania, where much of the general population lives and/or works in contact with livestock. A convenience sample of 51 patients with haematologic cancer undergoing chemotherapy at a referral clinic in Cluj-Napoca, Romania, was surveyed regarding animal exposures...
March 22, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28319680/first-genetic-evidence-of-coxiella-burnetii-in-cases-presenting-with-acute-febrile-illness-india
#17
Sanjay Kumar, Shefali Raj Gangoliya, Syed Imteyaz Alam, Satish Patil, Ganavalli Subramanya Ajantha, Raghavendra Dhirendra Kulkarni, Dev Vrat Kamboj
No abstract text is available yet for this article.
March 20, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28293541/high-content-imaging-reveals-expansion-of-the-endosomal-compartment-during-coxiella-burnetii-parasitophorous-vacuole-maturation
#18
Charles L Larson, Robert A Heinzen
Coxiella burnetii is an obligate intracellular pathogen and the causative agent of human Q fever. Replication of the bacterium within a large parasitophorous vacuole (PV) resembling a host phagolysosome is required for pathogenesis. PV biogenesis is a pathogen driven process that requires engagement of several host cell vesicular trafficking pathways to acquire vacuole components. The goal of this study was to determine if infection by C. burnetii modulates endolysosomal flux to potentially benefit PV formation...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28290594/-effects-of-vaccination-against-q-fever-in-lower-saxony-dairy-cattle-farms
#19
Stefanie Lehner, Katja Lohan, Heinz-Josef Dieckhoff, Ursula Gerdes
OBJECTIVE: Being a notifiable and zoonotic disease, Q-fever is coming under increasing focus of epizootic disease control. Current studies indicate that the disease is more widespread in Germany than the number of notifications suggest. Therefore, since 2013, under certain conditions a hardship allowance is granted by the Animal Diseases Fund of Lower Saxony for the vaccine costs of the basic immunization to support affected farms. Material und methods: All farmers, on whose farms clinical signs of Q-fever and the pathogen Coxiella burnetii had been detected prior to vaccination and who had taken advantage of the hardship allowance during the previous 2 years were surveyed to assess the effectiveness of the measure...
March 14, 2017: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/28284601/molecular-investigation-into-the-presence-of-a-coxiella-sp-in-rhipicephalus-sanguineus-ticks-in-australia
#20
Charlotte L Oskam, Alexander W Gofton, Telleasha L Greay, Rongchang Yang, Stephen Doggett, Una M Ryan, Peter J Irwin
Q fever is an infectious disease with a global distribution caused by the intracellular bacterium, Coxiella burnetii, which has been detected in a large number of tick species worldwide, including the brown dog tick, Rhipicephalus sanguineus. Recent reports of a high seroprevalance of C. burnetii in Australian dogs, along with the identification of additional Coxiella species within R. sanguineus ticks, has prompted an investigation into the presence and identification of Coxiella species in R. sanguineus ticks in Australia...
March 2017: Veterinary Microbiology
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