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https://www.readbyqxmd.com/read/28722568/epidemiology-of-spotted-fever-group-rickettsioses-and-acute-undifferentiated-febrile-illness-in-villeta-colombia
#1
Álvaro A Faccini-Martínez, Alejandro Ramírez-Hernández, Christian Barreto, Elkin Forero-Becerra, Diego Millán, Elkin Valbuena, Andrea C Sánchez-Alfonso, Wilson O Imbacuán-Pantoja, Jesús A Cortés-Vecino, Luis J Polo-Terán, Néstor Yaya-Lancheros, Jorge Jácome, Ana M Palomar, Sonia Santibáñez, Aránzazu Portillo, José A Oteo, Marylin Hidalgo
Etiology of acute undifferentiated febrile syndrome (AUFS) is often unknown, leading to inaccurate diagnosis and treatment. Villeta town has been identified as an endemic area for spotted fever group (SFG) rickettsioses but little is known about possible amplifier hosts and other Rickettsia species different from Rickettsia rickettsii. Besides, few studies have approached other AUFS etiologies in the region. We investigated the role of dengue, leptospirosis, rickettsioses, human anaplasmosis, and Q fever as possible causes of AUFS in patients from Villeta...
June 19, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28717320/coxiellosis-in-domestic-livestock-of-puducherry-and-tamil-nadu-detection-of-coxiella-burnetii-dna-by-polymerase-chain-reaction-in-slaughtered-ruminants
#2
Jothimani Pradeep, Selvaraj Stephen, Pratheesh Pooja, Anbalagan Akshayavardhini, Balakrishnan Sangeetha, Prabakar Xavier Antony
BACKGROUND AND AIM: In the course of our Indian Council of Medical Research project on coxiellosis in Puducherry and Tamil Nadu, 5.64% goat, 1.85% sheep, 1.06% buffaloes, and 0.97% cattle were positive for Coxiella burnetii antibodies by enzyme linked immunosorbent assay kit (IDEXX, Liebefeld, Switzerland). In this preliminary study, we have proceeded to look for C. burnetii DNA in those antibody positive specimens employing an imported commercial C. burnetii polymerase chain reaction (PCR) kit...
June 2017: Veterinary World
https://www.readbyqxmd.com/read/28715899/the-clinical-challenge-of-chronic-q-fever-with-isolated-liver-involvement
#3
Armando Peixoto, Pedro Pereira, Guilherme Macedo
Chronic Q fever is defined as an infection by Coxiella burnetii (C. burnetii) that lasts for six months or more. It occurs in 1-5% of individuals infected with this agent and develops over a period of months to years after the acute infection. Cases of hepatic involvement are rare.
July 18, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28713154/legionella-and-coxiella-effectors-strength-in-diversity-and-activity
#4
REVIEW
Jiazhang Qiu, Zhao-Qing Luo
Legionella pneumophila and Coxiella burnetii are two evolutionarily related intracellular pathogens that use the Dot/Icm type IV secretion system to translocate effectors into host cells. These effectors are essential for the establishment of membrane-bound compartments known as replication vacuoles, which enable the survival and replication of bacteria inside host cells. The effectors interfere with diverse signalling pathways to co-opt host processes, such as vesicle trafficking, ubiquitylation, gene expression and lipid metabolism, to promote pathogen survival...
July 17, 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28706879/multiple-substrate-usage-of-coxiella-burnetii-to-feed-a-bipartite-metabolic-network
#5
Ina Häuslein, Franck Cantet, Sarah Reschke, Fan Chen, Matteo Bonazzi, Wolfgang Eisenreich
The human pathogen Coxiella burnetii causes Q-fever and is classified as a category B bio-weapon. Exploiting the development of the axenic growth medium ACCM-2, we have now used (13)C-labeling experiments and isotopolog profiling to investigate the highly diverse metabolic network of C. burnetii. To this aim, C. burnetii RSA 439 NMII was cultured in ACCM-2 containing 5 mM of either [U-(13)C3]serine, [U-(13)C6]glucose, or [U-(13)C3]glycerol until the late-logarithmic phase. GC/MS-based isotopolog profiling of protein-derived amino acids, methanol-soluble polar metabolites, fatty acids, and cell wall components (e...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28672014/molecular-detection-of-coxiella-burnetii-from-the-formalin-fixed-tissues-of-q-fever-patients-with-acute-hepatitis
#6
Young-Rock Jang, Yong Shin, Choong Eun Jin, Bonhan Koo, Se Yoon Park, Min-Chul Kim, Taeeun Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Sung-Han Kim, Eunsil Yu
BACKGROUND: Serologic diagnosis is one of the most widely used diagnostic methods for Q fever, but the window period in antibody response of 2 to 3 weeks after symptom onset results in significant diagnostic delay. We investigated the diagnostic utility of Q fever PCR from formalin-fixed liver tissues in Q fever patients with acute hepatitis. METHODS: We reviewed the clinical and laboratory data in patients with Q fever hepatitis who underwent liver biopsy during a 17-year period, and whose biopsied tissues were available...
2017: PloS One
https://www.readbyqxmd.com/read/28670863/microbiological-zoonotic-emerging-risks-transmitted-between-livestock-animals-and-humans-2007-2015
#7
REVIEW
M E Filippitzi, T Goumperis, T Robinson, C Saegerman
As part of the Emerging Risk Identification (ERI) activities of the European Food Safety Authority (EFSA), a literature search was conducted to identify the microbiological agents transmitted between livestock animals and humans that have been suggested as having emerged between 2007 and 2015 in peer-reviewed scientific literature published during the same period (2007-2015). According to the criteria set, the search identified seven such zoonotic agents, namely West Nile Fever virus, Rift Valley Fever virus, Crimean-Congo Haemorrhagic Fever virus, Influenza A H1N1 virus, Coxiella burnetii, Streptococcus suis and livestock-associated methicillin-resistant Staphylococcus aureus clonal complex 398...
August 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28666604/a-human-time-dose-response-model-for-q-fever
#8
Charles W Heppell, Joseph R Egan, Ian Hall
The causative agent of Q fever, Coxiella burnetii, has the potential to be developed for use in biological warfare and it is classified as a bioterrorism threat agent by the Centers for Disease Control and Prevention (CDC) and as a category B select agent by the National Institute of Allergy and Infectious Diseases (NIAID). In this paper we focus on the in-host properties that arise when an individual inhales a dose of C. burnetii and establish a human time-dose response model. We also propagate uncertainty throughout the model allowing us to robustly estimate key properties including the infectious dose and incubation period...
June 15, 2017: Epidemics
https://www.readbyqxmd.com/read/28666412/an-integrated-study-of-human-and-animal-infectious-disease-in-the-lake-victoria-crescent-small-holder-crop-livestock-production-system-kenya
#9
Eric M Fèvre, William A de Glanville, Lian F Thomas, Elizabeth A J Cook, Samuel Kariuki, Claire N Wamae
BACKGROUND: The neglected zoonotic diseases (NZD) are an understudied group that are a major cause of illness throughout the developing world. In general, little is known about the prevalence and burden of NZDs in affected communities, particularly in relation to other infectious diseases with which they are often co-endemic. We describe the design and descriptive epidemiological outputs from an integrated study of human and animal zoonotic and non-zoonotic disease in a rural farming community in western Kenya...
June 30, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28651298/coxiella-burnetti-associated-thoracic-endovascular-stent-graft-infection
#10
Nicholas S Clarke, Scott I Reznik, Michael E Jessen, Raghav Murthy
No abstract text is available yet for this article.
June 26, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/28642842/the-tick-microbiome-why-non-pathogenic-microorganisms-matter-in-tick-biology-and-pathogen-transmission
#11
REVIEW
Sarah I Bonnet, Florian Binetruy, Angelica M Hernández-Jarguín, Olivier Duron
Ticks are among the most important vectors of pathogens affecting humans and other animals worldwide. They do not only carry pathogens however, as a diverse group of commensal and symbiotic microorganisms are also present in ticks. Unlike pathogens, their biology and their effect on ticks remain largely unexplored, and are in fact often neglected. Nonetheless, they can confer multiple detrimental, neutral, or beneficial effects to their tick hosts, and can play various roles in fitness, nutritional adaptation, development, reproduction, defense against environmental stress, and immunity...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28626230/engineering-of-obligate-intracellular-bacteria-progress-challenges-and-paradigms
#12
REVIEW
Erin E McClure, Adela S Oliva Chávez, Dana K Shaw, Jason A Carlyon, Roman R Ganta, Susan M Noh, David O Wood, Patrik M Bavoil, Kelly A Brayton, Juan J Martinez, Jere W McBride, Raphael H Valdivia, Ulrike G Munderloh, Joao H F Pedra
It is estimated that approximately one billion people are at risk of infection with obligate intracellular bacteria, but little is known about the underlying mechanisms that govern their life cycles. The difficulty in studying Chlamydia spp., Coxiella spp., Rickettsia spp., Anaplasma spp., Ehrlichia spp. and Orientia spp. is, in part, due to their genetic intractability. Recently, genetic tools have been developed; however, optimizing the genomic manipulation of obligate intracellular bacteria remains challenging...
June 19, 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28620582/physicochemical-and-nutritional-requirements-for-axenic-replication-suggest-physiological-basis-for-coxiella-burnetii-niche-restriction
#13
Eduardo Vallejo Esquerra, Hong Yang, Savannah E Sanchez, Anders Omsland
Bacterial obligate intracellular parasites are clinically significant animal and human pathogens. Central to the biology of these organisms is their level of adaptation to intracellular replication niches associated with physicochemical and nutritional constraints. While most bacterial pathogens can adapt to a wide range of environments, severe niche restriction-an inability to thrive in diverse environments-is a hallmark of bacterial obligate intracellular parasites. Herein the physicochemical and nutritional factors underlying the physiological basis for niche restriction in the zoonotic bacterial obligate intracellular parasite and Q fever agent Coxiella burnetii are characterized...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28616504/q-fever-in-an-endemic-region-of-north-queensland-australia-a-10%C3%A2-year-review
#14
Pirathaban Sivabalan, Apoorva Saboo, James Yew, Robert Norton
BACKGROUND: Q fever is a zoonotic infection caused by Coxiella burnetii. Endemic Q fever has long been recognised in north Queensland, with north Queensland previously acknowledged to have the highest rate of notification in Australia. In this retrospective study, we reviewed the demographics and exposure of patients diagnosed with Q fever in an endemic region of north Queensland, to identify trends and exposure factors for the acquisition of Q fever. METHODS: A retrospective study looking at patients in the region that had tested positive for Q fever by case ascertainment between 2004 and 2014...
June 2017: One Health
https://www.readbyqxmd.com/read/28616479/human-q-fever-incidence-is-associated-to-spatiotemporal-environmental-conditions
#15
J P G Van Leuken, A N Swart, J Brandsma, W Terink, J Van de Kassteele, P Droogers, F Sauter, A H Havelaar, W Van der Hoek
Airborne pathogenic transmission from sources to humans is characterised by atmospheric dispersion and influence of environmental conditions on deposition and reaerosolisation. We applied a One Health approach using human, veterinary and environmental data regarding the 2009 epidemic in The Netherlands, and investigated whether observed human Q fever incidence rates were correlated to environmental risk factors. We identified 158 putative sources (dairy goat and sheep farms) and included 2339 human cases. We performed a high-resolution (1 × 1 km) zero-inflated regression analysis to predict incidence rates by Coxiella burnetii concentration (using an atmospheric dispersion model and meteorological data), and environmental factors - including vegetation density, soil moisture, soil erosion sensitivity, and land use data - at a yearly and monthly time-resolution...
December 2016: One Health
https://www.readbyqxmd.com/read/28615092/-purification-of-the-recombinant-com1-and-adaa-of-coxiella-burnetii-and-identification-of-the-antigenicity
#16
Jingxian Liu, Yihong Ji, Zhiyang Shi, Yongjun Jiao
Objective To express and purify two kinds of antigens of Coxiella burnetii (C. burnetii), the main outer membrane protein Com1 and the acute disease antigen A (adaA), in prokaryotic expression system and to validate the two recombinant antigens by mass spectrometry and identify their antigenicity. Methods The gene sequences encoding Com1 and adaA were separately synthesized and constructed into the prokaryotic expression vector pET-20b(+). The constructed vectors were transformed into E.coli BL21(DE3), and the recombinant proteins were induced by IPTG...
June 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28613410/a-case-of-q-fever-after-liver-transplantation
#17
Lindsay A Petty, Helen S Te, Kenneth Pursell
Coxiella burnetii, the causative agent of Q fever, is a zoonosis that causes both acute and chronic disease in humans. Few cases have been reported in solid organ transplant recipients, and this case highlights the need to include Q fever in the differential diagnosis for fever of unknown origin in solid organ transplant hosts.
June 14, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28607026/efficacy-of-a-paromomycin-plus-chloroquine-combination-therapy-in-experimental-cutaneous-leishmaniasis
#18
Gert-Jan Wijnant, Katrien Van Bocxlaer, Vanessa Yardley, Sudaxshina Murdan, Simon Croft
The 4-aminoquinoline chloroquine (CQ) is clinically used in combination with doxycycline to cure chronic Q-fever, as it enhances the activity of the antibiotic against the causative Coxiella burnetii bacteria residing within macrophage phagolysosomes. As there is a similar cellular host-pathogen biology for Leishmania parasites, this study aimed to determine whether such an approach could be also the basis for a new, improved treatment for cutaneous leishmaniasis (CL). We have evaluated the in vitro and in vivo activity of combinations of CQ with standard drugs paromomycin (PM), miltefosine and amphotericin B against Leishmania major and Leishmania mexicana In 72-hour intracellular anti-leishmanial assays, outcomes were variable for different drugs...
June 12, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28596399/whole-genome-sequence-of-coxiella-burnetii-nine-mile-rsa439-phase-ii-clone-4-a-laboratory-workhorse-strain
#19
Jess A Millar, Paul A Beare, Abraham S Moses, Craig A Martens, Robert A Heinzen, Rahul Raghavan
Here, we report the whole-genome sequence of Coxiella burnetii Nine Mile RSA439 (phase II, clone 4), a laboratory strain used extensively to investigate the biology of this intracellular bacterial pathogen. The genome consists of a 1.97-Mb chromosome and a 37.32-kb plasmid.
June 8, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28593481/molecular-survey-of-coxiella-burnetii-in-wildlife-and-ticks-at-wildlife-livestock-interfaces-in-kenya
#20
David Ndeereh, Gerald Muchemi, Andrew Thaiyah, Moses Otiende, Samer Angelone-Alasaad, Michael J Jowers
Coxiella burnetii is the causative agent of Q fever, a zoonotic disease of public health importance. The role of wildlife and their ticks in the epidemiology of C. burnetii in Kenya is unknown. This study analysed the occurrence and prevalence of the pathogen in wildlife and their ticks at two unique wildlife-livestock interfaces of Laikipia and Maasai Mara National Reserve (MMNR) with the aim to determine the potential risk of transmission to livestock and humans. Blood from 79 and 73 animals in Laikipia and MMNR, respectively, and 756 and 95 ixodid ticks in each of the areas, respectively, was analysed...
June 7, 2017: Experimental & Applied Acarology
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