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https://www.readbyqxmd.com/read/28938256/chronic-q-fever-infections-in-israeli-children-a-25-year-nationwide-study
#1
Nimrod Sachs, Yafit Atiya-Nasagi, Adi Beth-Din, Itzhak Levy, Shalom Ben-Shimol, Diana Tasher, Galia Grisaru-Soen, Haleema Dabaja, Imad Kassis, Shiri Spilman, Efraim Bilavsky
BACKGROUND: Q fever is a zoonosis caused by the bacterium Coxiella burnetii (C. burnetii) with a worldwide distribution. Our aim was to assess the epidemiology, clinical manifestations and treatment regimens of chronic Q fever infections in Israeli children during the past 25 years. METHODS: Cases were collected from the national Q fever reference laboratory database. Demographic, epidemiologic, and clinical data were reviewed using a structured questionnaire sent to the referring physician...
September 20, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28935742/draft-genome-sequences-of-three-coxiella-burnetii-strains-isolated-from-q-fever-patients
#2
Paul A Beare, Brendan M Jeffrey, Craig A Martens, Robert A Heinzen
In the current study, we determined the draft genome sequences of three Coxiella burnetii human disease isolates. The Coxiella burnetii Turkey (RSA315) and Dyer (RSA345) strains were isolated from acute Q fever patients, while the Ko (Q229) strain was isolated from a Q fever endocarditis patient.
September 21, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28935173/coxiella-burnetiias-a-useful-tool-to-investigate-bacteria-friendly-host-cell-compartments
#3
REVIEW
Julian Pechstein, Jan Schulze-Luehrmann, Anja Lührmann
Coxiella burnetii is an obligate intracellular and airborne pathogen which can cause the zoonotic disease Q fever. After inhalation of contaminated aerosols alveolar macrophages are taking up C. burnetii into a phagosome. This phagosome matures to a very large vacuole called the C. burnetii-containing vacuole (CCV). Host endogenous and bacterial driven processes lead to the biogenesis of this unusual compartment, which resembles partially a phagolysosome. However, there are several important differences to the classical phagolysosome, which are crucial for the ability of C...
September 14, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/28933682/q-vaxcelerate-a-distributed-development-approach-for-a-new-coxiella-burnetii-vaccine
#4
Patrick M Reeves, Susan Raju Paul, Ann E Sluder, Timothy A Brauns, Mark C Poznansky
Development of vaccines that are both safe and effective remains a costly and time-consuming challenge. To accelerate the pace of development and improve the efficacy and safety of candidate vaccines for both existing and emerging infectious agents, we have employed a distributed development approach. This features the managed integration of individual expert groups having the requisite vaccine platforms, pre-clinical models, assays, skills and knowledge pertinent to a specific pathogen into a single, end-to-end development team capable of producing a new vaccine tailored to that particular agent...
September 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28931077/detection-of-bacterial-pathogens-including-potential-new-species-in-human-head-lice-from-mali
#5
Nadia Amanzougaghene, Florence Fenollar, Abdoul Karim Sangaré, Mahamadou S Sissoko, Ogobara K Doumbo, Didier Raoult, Oleg Mediannikov
In poor African countries, where no medical and biological facilities are available, the identification of potential emerging pathogens of concern at an early stage is challenging. Head lice, Pediculus humanus capitis, have a short life, feed only on human blood and do not transmit pathogens to their progeny. They are, therefore, a perfect tool for the xenodiagnosis of current or recent human infection. This study assessed the occurrence of bacterial pathogens from head lice collected in two rural villages from Mali, where a high frequency of head lice infestation had previously been reported, using molecular methods...
2017: PloS One
https://www.readbyqxmd.com/read/28915918/a-longitudinal-study-of-serological-responses-to-coxiella-burnetii-and-shedding-at-kidding-among-intensively-managed-goats-supports-early-use-of-vaccines
#6
Michael Muleme, Angus Campbell, John Stenos, Joanne M Devlin, Gemma Vincent, Alexander Cameron, Stephen Graves, Colin R Wilks, Simon Firestone
Vaccination against Coxiella burnetii, the cause of Q fever, is reportedly the only feasible strategy of eradicating infection in ruminant herds. Preventive vaccination of seronegative goats is more effective in reducing shedding of C. burnetii than vaccinating seropositive goats. The age at which goats born on heavily-contaminated farms first seroconvert to C. burnetii has not yet been documented. In a 16-month birth cohort study, the age at which goats seroconverted against C. burnetii was investigated; 95 goats were bled every 2 weeks and tested for antibodies against C...
September 15, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28899604/clinical-and-epidemiological-use-of-nested-pcr-targeting-the-repetitive-element-is1111-associated-with-the-transposase-gene-from-coxiella-burnetii
#7
Maria Angélica M M Mares-Guia, Alexandro Guterres, Tatiana Rozental, Michelle Dos Santos Ferreira, Elba R S Lemos
Q fever is a worldwide zoonosis caused by Coxiella burnetii-a small obligate intracellular Gram-negative bacterium found in a variety of animals. It is transmitted to humans by inhalation of contaminated aerosols from urine, feces, milk, amniotic fluid, placenta, abortion products, wool, and rarely by ingestion of raw milk from infected animals. Nested PCR can improve the sensitivity and specificity of testing while offering a suitable amplicon size for sequencing. Serial dilutions were performed tenfold to test the limit of detection, and the result was 10× detection of C...
August 24, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/28899307/atypical-outbreak-of-q-fever-affecting-low-risk-residents-of-a-remote-rural-town-in-new-south-wales
#8
Brett N Archer, Cathie Hallahan, Priscilla Stanley, Kathy Seward, Margaret Lesjak, Kirsty Hope, Anthony Brown
We investigated an outbreak of Q fever in a remote rural town in New South Wales, Australia. Cases identified through active and passive case finding activities, and retrospective laboratory record review were interviewed using a standard questionnaire. Two sets of case-case analyses were completed to generate hypotheses regarding clinical, epidemiological and exposure risk factors associated with infection during the outbreak. Laboratory-confirmed outbreak cases (n=14) were compared with an excluded case group (n=16) and a group of historic Q fever cases from the region (n=106)...
June 30, 2017: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/28893076/seroprevalence-and-risk-factors-for-i-coxiella-burnetii-i-the-causative-agent-of-q-fever-in-the-dromedary-camel-i-camelus-dromedarius-i-population-in-algeria
#9
Mohammed H Benaissa, Samir Ansel, Abdallah Mohamed-Cherif, Karima Benfodil, Djamel Khelef, Curtis R Youngs, Rachid Kaidi, Khatima Ait-Oudhia
Query (Q) fever is a globally distributed zoonotic disease caused by Coxiella burnetii, a bacterial agent for which ruminants are the most prevalent natural reservoir. Data regarding Q fever infection in camels in Algeria are limited. Therefore, a survey to detect seroprevalence of C. burnetii antibodies was conducted among healthy camel populations in a vast area in southeastern Algeria to determine distribution of the Q fever causative organism and to identify risk factors associated with infection. Between January and March 2016, blood samples were collected from 184 camels and serum samples were subsequently analysed using a commercial Enzyme-Linked Immunosorbent Assay (ELISA) kit...
August 31, 2017: Onderstepoort Journal of Veterinary Research
https://www.readbyqxmd.com/read/28887650/microbial-diversity-of-the-tibetan-tick-haemaphysalis-tibetensis-acari-ixodidae
#10
Zhijun Yu, Rongrong Wang, Ningxin Li, Chunmian Zhang, Jingze Liu
The Tibetan tick Haemaphysalis tibetensis is widely distributed in the Tibetan Plateau, and is recognized as one of the primary parasites affecting domestic and wild animals. No information is available on its microbial diversity. In the current study, the microbiomes in H. tibetensis were explored using Illumina MiSeq sequencing. Results indicate that a total of 28 phyla and 38 genera were characterized from this tick, and most of the microbes were classified in the phylum Proteobacteria. Female and male H...
September 8, 2017: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/28886749/bacterial-microbiota-associated-with-rhipicephalus-sanguineus-s-l-ticks-from-france-senegal-and-arizona
#11
Magalie René-Martellet, Guillaume Minard, Raphael Massot, Van Tran Van, Claire Valiente Moro, Luc Chabanne, Patrick Mavingui
BACKGROUND: Ticks of the group Rhipicephalus sanguineus (sensu lato) are distributed worldwide and are major pathogen vectors of both dogs and humans. Previous phylogenetic reconstructions have suggested the existence of two main lineages within this group, "Tropical" and "Temperate". Symbiotic interactions contribute to vector development, survival, reproduction and competence. The diversity of microbial communities associated with different populations of R. sanguineus (s.l.) remains poorly characterized, however, this knowledge will aid in future studies of hosts-microbiota-pathogen interactions...
September 7, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28878740/dna-delivery-and-genomic-integration-into-mammalian-target-cells-through-type-iv-a-and-b-secretion-systems-of-human-pathogens
#12
Dolores L Guzmán-Herrador, Samuel Steiner, Anabel Alperi, Coral González-Prieto, Craig R Roy, Matxalen Llosa
We explore the potential of bacterial secretion systems as tools for genomic modification of human cells. We previously showed that foreign DNA can be introduced into human cells through the Type IV A secretion system of the human pathogen Bartonella henselae. Moreover, the DNA is delivered covalently attached to the conjugative relaxase TrwC, which promotes its integration into the recipient genome. In this work, we report that this tool can be adapted to other target cells by using different relaxases and secretion systems...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28878055/interacting-effects-of-wildlife-loss-and-climate-on-ticks-and-tick-borne-disease
#13
Georgia Titcomb, Brian F Allan, Tyler Ainsworth, Lauren Henson, Tyler Hedlund, Robert M Pringle, Todd M Palmer, Laban Njoroge, Michael G Campana, Robert C Fleischer, John Naisikie Mantas, Hillary S Young
Both large-wildlife loss and climatic changes can independently influence the prevalence and distribution of zoonotic disease. Given growing evidence that wildlife loss often has stronger community-level effects in low-productivity areas, we hypothesized that these perturbations would have interactive effects on disease risk. We experimentally tested this hypothesis by measuring tick abundance and the prevalence of tick-borne pathogens (Coxiella burnetii and Rickettsia spp.) within long-term, size-selective, large-herbivore exclosures replicated across a precipitation gradient in East Africa...
September 13, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28873022/seroprevalence-of-leptospirosis-brucellosis-and-q-fever-in-a-wild-red-deer-cervus-elaphus-population-kept-in-a-fenced-reserve-in-absence-of-contact-with-livestock
#14
Jose María San-Miguel Ayanz, Francisco Javier Garcia-Peña, Paula García-Lunar, Luis Miguel Ortega-Mora, María José Ruano, Gema Álvarez-García, Esther Collantes-Fernández
Wildlife health is of interest for public and animal health because wild animals have been identified as important sentinels for the surveillance for zoonotic pathogens. This work investigated Brucella spp., Coxiella burnetii, and Leptospira spp. infection seroprevalence in a free-ranging red deer population. The study was conducted in a fenced reserve with controlled hunting activity in central Spain with animals that did not have any contact with livestock. Sampling was performed at two time points before and 5 years after the implementation of new management measures, including a reduction in the red deer population in the reserve...
September 5, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28867393/reprint-of-epidemiology-of-brucellosis-q-fever-and-rift-valley-fever-at-the-human-and-livestock-interface-in-northern-c%C3%A3-te-d-ivoire
#15
Youssouf B Kanouté, Biégo G Gragnon, Christian Schindler, Bassirou Bonfoh, Esther Schelling
Northern Côte d'Ivoire is the main livestock breeding zone and has the highest livestock cross-border movements in Côte d'Ivoire. The aim of this study was to provide updated epidemiological data on three neglected zoonotic diseases, namely brucellosis, Q Fever and Rift Valley Fever (RVF). We conducted three-stage cross-sectional cluster surveys in livestock and humans between 2012 and 2014 in a random selection of 63 villages and a sample of 633 cattle, 622 small ruminants and 88 people. We administered questionnaires to capture risk factors and performed serological tests including the Rose Bengal Plate Test (RBPT), Brucella spp...
September 1, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28856082/atypical-bacterial-pneumonia-in-the-hiv-infected-population
#16
REVIEW
Breanne M Head, Adriana Trajtman, Zulma V Rueda, Lázaro Vélez, Yoav Keynan
Human immunodeficiency virus (HIV)-infected individuals are more susceptible to respiratory tract infections by other infectious agents (viruses, bacteria, parasites, and fungi) as their disease progresses to acquired immunodeficiency syndrome. Despite effective antiretroviral therapy, bacterial pneumonia (the most frequently occurring HIV-associated pulmonary illness) remains a common cause of morbidity and mortality in the HIV-infected population. Over the last few decades, studies have looked at the role of atypical bacterial pneumonia (i...
2017: Pneumonia
https://www.readbyqxmd.com/read/28854806/coxiella-burnetii-immunogenic-proteins-as-a-basis-for-new-q-fever-diagnostic-and-vaccine-development
#17
C Gerlach, Ľ Škultéty, K Henning, H Neubauer, K Mertens
Coxiella burnetii is the etiological agent of the zoonosis Q fever, which can cause an acute or a chronic, life-threatening disease in humans. It presents a highly stable cell form, which persists in the environment and is transmitted via contaminated aerosols. Ruminants are considered as the main reservoir for human infections but are usually asymptomatic. Subclinical infection in these animals and the occurrence of serologically negative shedders hamper the identification of infected animals with the currently used diagnostic techniques...
2017: Acta Virologica
https://www.readbyqxmd.com/read/28854805/two-mice-models-for-transferability-of-zoonotic-bacteria-via-tick-vector
#18
B Sallay, T Vaculová, M Derdáková, V Rusňáková Tarageľová, E Špitalská, Ľ Škultéty
Spotted fever and typhus-related diseases caused by rickettsiae, Lyme borreliosis induced by spirochetes from Borrelia burgdorferii sensu lato complex, and Q fever evoked by Coxiella burnetii, are important zoonoses occurring worldwide. In order to study the pathogenesis of these infections, the efficacy of vaccines from the perspective of protection against the pathogens, pathogen - pathogen interactions during co-infections or pathogen-vector-host interrelationship, a suitable animal model should be established...
2017: Acta Virologica
https://www.readbyqxmd.com/read/28854804/seroprevalence-of-coxiella-burnetii-among-domestic-ruminants-and-horses-in-poland
#19
M Szymańska-Czerwińska, A Jodełko, M Pluta, S Kowalik, K Niemczuk
Coxiella burnetii is the causative agent of Q fever. The cases of the disease are recorded in various species, including domestic animals. The aim of this investigation was to estimate the seroprevalence of C. burnetii in ruminants including cattle, sheep, goats, and horses. Totally, 2082 serum samples from 936 goats, 933 cattle, 89 sheep, and 124 horses, including various horse breeds, were tested by ELISA or complement fixation test. The examination revealed that Polish horses are seronegative while in the populations of cattle and small ruminants, seropositive animals are presented...
2017: Acta Virologica
https://www.readbyqxmd.com/read/28854803/protein-composition-of-the-phase-i-coxiella-burnetii-soluble-antigen-prepared-by-extraction-with-trichloroacetic-acid
#20
G Flores-Ramírez, M Kmeťová, M Danchenko, E Špitalská, V Havlíček, Ľ Škultéty
Q fever is a highly infectious, widespread airborne zoonosis caused by Coxiella burnetii bacterium. Humans usually acquire the disease by inhalation of contaminated aerosol produced by infected livestock. Vaccination is the most practical way for prevention and control of the disease in the exposed population. In this work, we reviewed the most important Q-fever outbreaks in Slovakia as well as the progress in vaccine development. One of them represents a soluble antigen complex produced by extraction with trichloroacetic acid from a highly purified C...
2017: Acta Virologica
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