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https://www.readbyqxmd.com/read/29331581/identification-and-characterization-of-arginine-finger-like-motifs-and-endosome-lysosome-basolateral-sorting-signals-within-ectopically-expressed-cira-a-coxiella-burnetii-type-iv-secreted-effector-protein
#1
Mary M Weber, Robert Faris, Erin J van Schaik, James E Samuel
Coxiella burnetii is an obligate intracellular pathogen that replicates in an endolysosome-like compartment termed the Coxiella-containing vacuole (CCV). Formation of this unique replicative niche requires delivery of bacterial effector proteins into the host cytosol where they mediate crucial interactions with the host. We previously identified an essential Dot/Icm effector, CirA that is required for intracellular replication and CCV formation. Furthermore, CirA was shown to stimulate the GTPase activity of RhoA in vitro...
January 10, 2018: Microbes and Infection
https://www.readbyqxmd.com/read/29327963/antemortem-diagnosis-of-coxiellosis-in-a-blue-and-gold-macaw-ara-ararauna
#2
Alison J Flanders, Justin F Rosenberg, Marjorie Bercier, Mary K Leissinger, Laura J Black, Robson F Giglio, Serena L M Craft, Whitney M Zoll, April L Childress, James F X Wellehan
A 15-year-old female blue and gold macaw ( Ara ararauna) was presented for evaluation after being found laterally recumbent, reluctant to move, and lethargic. Results of a complete blood count showed an increased number of immature heterophils with increased cytoplasmic basophilia and degranulation and the presence of a left shift. Radiographs and a computed tomography scan were performed and revealed a markedly enlarged spleen. An ultrasound-guided fine-needle aspirate of the spleen was submitted for cytologic examination and aerobic bacterial culture...
December 2017: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/29321921/farming-q-fever-and-public-health-agricultural-practices-and-beyond
#3
REVIEW
Marcella Mori, Hendrik-Jan Roest
Since the Neolithic period, humans have domesticated herbivores to have food readily at hand. The cohabitation with animals brought various advantages that drastically changed the human lifestyle but simultaneously led to the emergence of new epidemics. The majority of human pathogens known so far are zoonotic diseases and the development of both agricultural practices and human activities have provided new dynamics for transmission. This article provides a general overview of some factors that influence the epidemic potential of a zoonotic disease, Q fever...
2018: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/29311245/both-mhc-class-i-and-class-ii-molecules-are-required-while-mhc-i-appears-to-play-a-critical-role-in-host-defense-against-primary-coxiella-burnetii-infection
#4
Laura Buttrum, Lindsey Ledbetter, Rama Cherla, Yan Zhang, William J Mitchell, Guoquan Zhang
To understand the role of class I major histocompatibility complex (MHC-I) and class II MHC (MHC-II) antigen presentation pathways in host defense against C. burnetii infection, we examined if MHC-I or MHC-II deficiency in mice would significantly influence their susceptibility to virulent C. burnetii Nine Mile phase I (NMI) infection. The results indicate that NMI infection induced more severe disease in both MHC-I deficient and MHC-II deficient mice compared to WT mice, while only MHC-I deficient mice developed a severe persistent infection and were unable to control bacterial replication...
January 8, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29311244/coxiella-burnetii-inhibits-neutrophil-apoptosis-by-exploiting-survival-pathways-and-anti-apoptotic-protein-mcl-1
#5
Rama Cherla, Yan Zhang, Lindsey Ledbetter, Guoquan Zhang
Our previous study demonstrated that neutrophils play an important role in host defense against Coxiella burnetii infection in mice. In this study, C. burnetii avirulent Nine Mile phase II (NMII) was used to examine if C. burnetii can modulate mouse bone marrow-derived neutrophil apoptosis. The results indicated that NMII can inhibit neutrophil apoptosis. Western blotting demonstrated that caspase-3 cleavage was decreased, while phosphorylated mitogen-activated protein kinase (MAPK) p38 and extracellular signal-regulated kinase 1 (Erk1) were increased in NMII-infected neutrophils...
January 8, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29287100/phylogenetic-inference-of-coxiella-burnetii-by-16s-rrna-gene-sequencing
#6
Heather P McLaughlin, Blake Cherney, Janetta R Hakovirta, Rachael A Priestley, Andrew Conley, Andrew Carter, David Hodge, Segaran P Pillai, Linda M Weigel, Gilbert J Kersh, David Sue
Coxiella burnetii is a human pathogen that causes the serious zoonotic disease Q fever. It is ubiquitous in the environment and due to its wide host range, long-range dispersal potential and classification as a bioterrorism agent, this microorganism is considered an HHS Select Agent. In the event of an outbreak or intentional release, laboratory strain typing methods can contribute to epidemiological investigations, law enforcement investigation and the public health response by providing critical information about the relatedness between C...
2017: PloS One
https://www.readbyqxmd.com/read/29287070/a-diagnostic-and-epidemiologic-investigation-of-acute-febrile-illness-afi-in-kilombero-tanzania
#7
Christine Hercik, Leonard Cosmas, Ondari D Mogeni, Newton Wamola, Wanze Kohi, Victor Omballa, Melvin Ochieng, Shirley Lidechi, Juma Bonventure, Caroline Ochieng, Clayton Onyango, Barry S Fields, Sayoki Mfinanga, Joel M Montgomery
INTRODUCTION: In low-resource settings, empiric case management of febrile illness is routine as a result of limited access to laboratory diagnostics. The use of comprehensive fever syndromic surveillance, with enhanced clinical microbiology, advanced diagnostics and more robust epidemiologic investigation, could enable healthcare providers to offer a differential diagnosis of fever syndrome and more appropriate care and treatment. METHODS: We conducted a year-long exploratory study of fever syndrome among patients ≥ 1 year if age, presenting to clinical settings with an axillary temperature of ≥37...
2017: PloS One
https://www.readbyqxmd.com/read/29284250/serological-prevalence-of-coxiella-burnetii-in-dairy-goats-and-ewes-diagnosed-with-adverse-pregnancy-outcomes-in-greece
#8
George Filioussis, Alexandros Theodoridis, Dimitrios Papadopoulos, Athanasios I Gelasakis, Sotiria Vouraki, George Bramis, Georgios Arsenos
INTRODUCTION: <i>Coxiella burnetii</i> is an obligatory intracellular bacterial pathogen causing the zoonotic disease Q fever. The most common reservoirs of <i>C. burnetii</i> are wild mammals, birds and ticks. Pregnant domestic ruminants infected with this bacterium are also a major source of human infection. MATERIAL AND METHODS: The serological prevalence of <i>C. burnetii</i> in goats and sheep diagnosed with adverse pregnancy outcomes was assessed by undertaking a survey on 800 dairy goats and 800 dairy ewes reared in four different regions of Greece (Macedonia, Thrace, Thessaly, and Peloponnese)...
December 23, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29260491/molecular-detection-of-chlamydophila-abortus-coxiella-burnetii-and-mycoplasma-agalactiae-in-small-ruminants-aborted-fetuses-in-southern-iran
#9
S Heidari, Abdollah Derakhshandeh, R Firouzi, M Ansari-Lari, M Masoudian, V Eraghi
Abortion in sheep and goats has become increasingly important worldwide because of the significant economic losses and potential zoonotic implication of commonly involved pathogens. Therefore, this cross-sectional study was conducted in southern Iran to detect the Chlamydophila abortus and Coxiella burnetii, as zoonotic pathogens, and Mycoplasma agalactiae, as a neglected abortifacient agent in small ruminants' aborted fetuses, by using polymerase chain reaction (PCR). From a total of 300 aborted fetuses (183 sheep and 117 goats), 46 samples (15...
December 19, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29259632/epidemiology-of-q-fever-in-iran-a-systematic-review-and-meta-analysis-for-estimating-serological-and-molecular-prevalence
#10
REVIEW
Zary Nokhodian, Awat Feizi, Behrooz Ataei, Shervin Ghaffari Hoseini, Ehsan Mostafavi
Background: Q fever is endemic in Iran, thus, we conducted a systematic review and meta-analysis on epidemiology of Coxiella burnetii among humans and animals in Iran. Materials and Methods: A systematic search was performed to identify all articles reporting C. burnetii prevalence in Iranian humans or animals, published from January 2000 to January 2015. Data from articles were extracted, and a pooled estimate of prevalence with corresponding 95% confidence interval (CI) was calculated using random effect method...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29251170/coxiella-burnetii-infection-q-fever-mimicking-systemic-lupus-erythematosus-two-cases
#11
S Durupt, M Puget, J C Lega, I Durieu, Q Reynaud
Q fever has extremely polymorphic features, and has been reported to be associated with positivity of several autoimmune antibodies. We report two cases of atypical Q fever with a clinical presentation highly suggestive of an inflammatory systemic disease with positivity of autoimmune antibodies, mimicking systemic lupus erythematosus.
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/29250914/risk-of-exposure-to-coxiella-burnetii-from-ruminant-livestock-exhibited-at-iowa-agricultural-fairs
#12
K M Still Brooks, W R Stensland, K M Harmon, A M O'Connor, P J Plummer
Coxiella burnetii is a zoonotic pathogen typically associated with clinical and asymptomatic infection in ruminant livestock. A re-emerging pathogen of significant public health importance, C. burnetii has caused recent epidemics in the United States and Europe, and public livestock exhibitions are increasingly scrutinized as a potential source of C. burnetii exposure. Although C. burnetii prevalence data among North American domestic ruminants are extremely limited, contemporary studies suggest that this pathogen is both geographically widespread and highly prevalent on a herd basis, especially in dairy cattle and goat populations...
December 17, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29250787/metagenomics-in-pooled-plasma-with-identification-of-potential-emerging-infectious-pathogens
#13
Min Xu, Yashan Yang, Ya Zhou, Zhiyang Liu, Yu Liu, Miao He
BACKGROUND: Many emerging infectious pathogens are well known for existing in healthy blood donors and could be transmitted via blood transfusion or plasma derivatives usage. Therefore, there is an urgent need to discover the pathogens in qualified blood donation to avoid potential threats to blood safety. STUDY DESIGN AND METHODS: The objective of this study was to investigate the microbiome that existed in pooled plasma from different manufacturers in Chengdu and Guiyang...
December 17, 2017: Transfusion
https://www.readbyqxmd.com/read/29242567/a-coxiella-mutualist-symbiont-is-essential-to-the-development-of-rhipicephalus-microplus
#14
Melina Garcia Guizzo, Luís Fernando Parizi, Rodrigo Dutra Nunes, Renata Schama, Rodolpho M Albano, Lucas Tirloni, Daiane Patrícia Oldiges, Ricardo Pilz Vieira, Wanderson Henrique Cruz Oliveira, Milane de Souza Leite, Sergio A Gonzales, Marisa Farber, Orlando Martins, Itabajara da Silva Vaz, Pedro L Oliveira
The cattle tick Rhipicephalus microplus is a hematophagous ectoparasite that causes important economic losses in livestock. Different species of ticks harbor a symbiont bacterium of the genus Coxiella. It was showed that a Coxiella endosymbiont from R. microplus (CERM) is a vertically transmitted mutualist symbiont, comprising 98% of the 16S rRNA sequences in both eggs and larvae. Sequencing of the bacterial genome revealed genes for biosynthetic pathways for several vitamins and key metabolic cofactors that may provide a nutritional complement to the tick host...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29238456/seroepidemiological-study-of-q-fever-in-lorestan-province-western-iran-2014
#15
Mohammad Hassan Kayedi, Hamid Mokhayeri, Mehdi Birjandi, Ali Chegeni-Sharafi, Saber Esmaeili, Ehsan Mostafavi
Background and Objectives: Q fever is a zoonotic disease and farm animals serve as the main reservoir of the disease. The aim of this study was to evaluate the seroprevalence of Q fever in sheep, in Lorestan province in western Iran. Materials and Methods: In this cross-sectional study, 330 blood samples were collected from sheep, from each county in Lorestan province. The samples were tested by ELISA for the presence of immunoglobulin (IgG) against Coxiella burnetii...
August 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29207703/diagnosis-of-acute-q-fever-by-detection-of-coxiella-burnetii-dna-using-real-time-pcr-employing-a-commercial-genesig-easy-kit
#16
Jothimani Pradeep, Selvaraj Stephen, Stanley Ambroise, Dhandapany Gunasekaran
Introduction: Query (Q) fever is an important zoonosis and a cause of concern for humans, due to the potential bioterrorism threat posed by the causative agent, Coxiella burnetii. Because of the danger of contracting the illness, isolation attempts are seldom made. Serological and molecular diagnostic tests are the main option. Aim: To study the prevalence of acute Q fever in Puducherry and surrounding districts of Tamil Nadu, India, employing a new commercial Real-Time Polymerase Chain Reaction (RT-PCR) kit and confirming it by the gold standard Immunofluorescence Assay (IFA)...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29201381/culture-independent-genome-sequencing-of-coxiella-burnetii-from-a-native-heart-valve-of-a-tunisian-patient-with-severe-infective-endocarditis
#17
J Delaloye, T Pillonel, M Smaoui, A Znazen, L Abid, G Greub
We report draft genome of a Coxiella burnetii strain sequenced from the native valve of a patient presenting with severe endocarditis in Tunisia. The genome could be sequenced without a cellular or axenic culture step. The MST5 strain was demonstrated to be closely related to the published reference genome of C. burnetii CbuK_Q154.
January 2018: New Microbes and New Infections
https://www.readbyqxmd.com/read/29197401/neglected-zoonotic-agents-in-cattle-abortion-tackling-the-difficult-to-grow-bacteria
#18
Sara Vidal, Kristel Kegler, Gilbert Greub, Sebastien Aeby, Nicole Borel, Mark P Dagleish, Horst Posthaus, Vincent Perreten, Sabrina Rodriguez-Campos
BACKGROUND: Coxiella burnetii, Chlamydia abortus and Leptospira spp. are difficult to grow bacteria that play a role in bovine abortion, but their diagnosis is hampered by their obligate intracellular lifestyle (C. burnetii, C. abortus) or their lability (Leptospira spp.). Their importance is based on the contagious spread in food-producing animals, but also as zoonotic agents. In Switzerland, first-line routine bacteriological diagnostics in cattle abortions is regulated by national law and includes only basic screening by staining for C...
December 2, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29197022/endosymbiont-cls-hi-plays-a-role-in-reproduction-and-development-of-haemaphysalis-longicornis
#19
Chun-Mian Zhang, Ning-Xin Li, Tian-Tian Zhang, Zhao-Xi Qiu, Yuan Li, Li-Wu Li, Jing-Ze Liu
Coxiella-like endosymbiont (CLS-Hl) is a primary endosymbiont of Haemaphysalis longicornis. CLS-Hl infects tick special tissues and its prevalence is 100% in ovaries and Malpighian tubules. Tetracycline was injected into females, which then fed on rabbits also treated with tetracycline. The densities of CLS-Hl were measured by semi-quantitative PCR. CLS-Hl densities in ovaries and Malpighian tubes of H. longicornis had significant effects on engorged weight, feeding time, number of eggs, oviposition period, and hatching period...
December 2017: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/29189951/ticks-and-bacterial-tick-borne-pathogens-in-piemonte-region-northwest-italy
#20
Dario Pistone, Massimo Pajoro, Eva Novakova, Nadia Vicari, Cesare Gaiardelli, Roberto Viganò, Camilla Luzzago, Matteo Montagna, Paolo Lanfranchi
A molecular screening for tick-borne pathogens was carried out in engorged and in questing ticks collected in Verbano Cusio Ossola county, Piemonte region, Italy. Engorged ticks were removed from wild and domestic animal hosts. The most abundant and common tick species in the area was Ixodes ricinus (192 adults, 907 nymphs). Few individuals of Ixodes hexagonus (15) and Rhipicephalus sanguineus (7) were found among the ticks removed from domestic animals (46 examined ticks). The presence of Rickettsia spp., Borrelia burgdorferi sensu latu, Francisella tularensis and Coxiella burnetii was evaluated by PCR and sequencing in 392 individuals of I...
December 2017: Experimental & Applied Acarology
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