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https://www.readbyqxmd.com/read/29650498/five-years-post-nirbhaya-critical-insights-into-the-status-of-response-to-sexual-assault
#1
Sunita Vs Bandewar, Amita Pitre, Lakshmi Lingam
It is five years since the fatal gang rape of Jyothi Singh (Nirbhaya), a physiotherapy student, on December 16, 2012, in New Delhi, the capital of India. The legal and policy reforms triggered by the Nirbhaya case will remain a watershed moment in the history of efforts towards seeking justice for survivors of gender-based violence in India. The Criminal Law (Amendment) Act, 2013 and the "Guidelines and protocols: Medico-legal care for survivors/victims of sexual violence" issued by the Ministry of Health and Family Welfare in March 2014 are two landmark reforms...
March 28, 2018: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/29619624/chinese-guidelines-for-treatment-of-adult-primary-immune-thrombocytopenia
#2
Xin-Guang Liu, Xiao-Chuan Bai, Fang-Ping Chen, Yun-Feng Cheng, Ke-Sheng Dai, Mei-Yun Fang, Jian-Ming Feng, Yu-Ping Gong, Tao Guo, Xin-Hong Guo, Yue Han, Luo-Jia Hong, Yu Hu, Bao-Lai Hua, Rui-Bing Huang, Yan Li, Jun Peng, Mi-Mi Shu, Jing Sun, Pei-Yan Sun, Yu-Qian Sun, Chun-Sen Wang, Shu-Jie Wang, Xiao-Min Wang, Cong-Ming Wu, Wen-Man Wu, Zhen-Yu Yan, Feng-E Yang, Lin-Hua Yang, Ren-Chi Yang, Tong-Hua Yang, Xu Ye, Guang-Sen Zhang, Lei Zhang, Chang-Cheng Zheng, Hu Zhou, Min Zhou, Rong-Fu Zhou, Ze-Ping Zhou, Hong-Li Zhu, Tie-Nan Zhu, Ming Hou
Primary immune thrombocytopenia (ITP) is a bleeding disorder commonly encountered in clinical practice. The International Working Group (IWG) on ITP has published several landmark papers on terminology, definitions, outcome criteria, bleeding assessment, diagnosis, and management of ITP. The Chinese consensus reports for diagnosis and management of adult ITP have been updated to the 4th edition. Based on current consensus positions and new emerging clinical evidence, the thrombosis and hemostasis group of the Chinese Society of Hematology issued Chinese guidelines for management of adult ITP, which aim to provide evidence-based recommendations for clinical decision making...
April 4, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29617197/diagnosis-or-diagnosing-from-symptoms-to-a-phenomenological-psychoanalytic-stance-on-the-patient-s-world
#3
Mario Rossi Monti, Alessandra D'Agostino
While on the one hand therapists can count on a number of codified and standardized diagnostic procedures, on the other hand it is hard to believe that in their daily work therapists slavishly follow these standardized procedures. In a clinical assessment, the diagnosis seems to be the outcome of a naïve and fuzzy process that is strongly influenced by personal training, by, theoretical models, and by one's masters as well as the experience gained in the field. What happens inside the no man's land of the clinical encounter? Can we identify some landmarks in these "amoeboid" exploratory moves? This paper addresses diagnosis not only as a noun or name ("diagnosis"), but also as a verb ("diagnosing"), arguing that a diagnostic space opens up thanks to an oscillatory state of mind that emerges at the intersection of different ways of looking "through" the symptom...
April 2018: Psychoanalytic Review
https://www.readbyqxmd.com/read/29603689/cim-journal-club-gene-therapy-for-spinal-muscular-atrophy-comment-on-mendell-et-al-n-engl-j-med-2017-377-1713-22
#4
Raphael Schneider
In their landmark paper, Mendell et al. show that infants with spinal muscular atrophy (SMA) reached important motor milestones and survived longer when treated with AVXS-101 (AveXis), a viral vector containing DNA encoding the survival of motor neuron protein (SMN). Patients not only crawled, stood and walked independently, but learned to speak. These results are very encouraging for patients with SMA and offer hope for pediatric and adult patients with other types of motor neuron diseases.
March 27, 2018: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/29575193/synaptic-organization-of-the-dorsal-lateral-geniculate-nucleus
#5
Martha Bickford
A half century after Ray Guillery's classic descriptions of cell types, axon types, and synaptic architecture of the dorsal lateral geniculate nucleus, the functional organization of this nucleus, as well as all other thalamic nuclei, is still of enormous interest. This review will focus on 2 classic papers written by Ray Guillery: "A study of Golgi preparations from the dorsal lateral geniculate nucleus of the adult cat", and "The organization of synaptic interconnections in the laminae of the dorsal lateral geniculate nucleus of the cat", as well as the studies that most directly followed from the insights these landmark manuscripts provided...
March 25, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29574299/deep-facial-analysis-a-new-phase-i-epilepsy-evaluation-using-computer-vision
#6
David Ahmedt-Aristizabal, Clinton Fookes, Kien Nguyen, Simon Denman, Sridha Sridharan, Sasha Dionisio
Semiology observation and characterization play a major role in the presurgical evaluation of epilepsy. However, the interpretation of patient movements has subjective and intrinsic challenges. In this paper, we develop approaches to attempt to automatically extract and classify semiological patterns from facial expressions. We address limitations of existing computer-based analytical approaches of epilepsy monitoring, where facial movements have largely been ignored. This is an area that has seen limited advances in the literature...
March 22, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29571046/the-contributions-of-dr-kathleen-k-sulik-to-fetal-alcohol-spectrum-disorders-research-and-prevention
#7
REVIEW
Scott E Parnell, Edward P Riley, Kenneth R Warren, Kathleen T Mitchell, Michael E Charness
Dr. Kathleen Sulik (Kathy) has spent 35 years studying fetal alcohol syndrome (FAS) and fetal alcohol spectrum disorders (FASD). Beginning with her landmark 1981 Science paper describing the early gestational window when alcohol can cause the craniofacial malformations characteristic of FAS, Kathy has contributed a vast amount of research furthering our knowledge of FASD. After her seminal work that definitively demonstrated that alcohol is the causative factor in FAS, she and her lab went on to explore and define the stage-dependent effects of early gestational alcohol exposure on the face and brain in numerous different ways throughout her career...
March 20, 2018: Alcohol
https://www.readbyqxmd.com/read/29569852/toward-personalized-treatment-for-systemic-juvenile-idiopathic-arthritis
#8
EDITORIAL
Sebastiaan J Vastert, Peter A Nigrovic
The past 15 years have witnessed substantial gains in the understanding of systemic juvenile idiopathic arthritis (systemic JIA), also known as Still's disease. Although classified under the JIA umbrella, this rare chronic inflammatory disorder presents with fever and rash in addition to arthritis and is thus phenotypically distinct from other forms of JIA. In a landmark paper in 2005, Pascual and colleagues demonstrated a major role of interleukin (IL)-1 in systemic JIA (1). This article is protected by copyright...
March 23, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29560446/rehabgame-a-non-immersive-virtual-reality-rehabilitation-system-with-applications-in-neuroscience
#9
Shabnam Sadeghi Esfahlani, Tommy Thompson, Ali Davod Parsa, Ian Brown, Silvia Cirstea
This paper proposes the use of a non-immersive virtual reality rehabilitation system "ReHabgame" developed using Microsoft Kinect™ and the Thalmic™ Labs Myo gesture control armband. The ReHabgame was developed based on two third-person video games that provide a feasible possibility of assessing postural control and functional reach tests. It accurately quantifies specific postural control mechanisms including timed standing balance, functional reach tests using real-time anatomical landmark orientation, joint velocity, and acceleration while end trajectories were calculated using an inverse kinematics algorithm...
February 2018: Heliyon
https://www.readbyqxmd.com/read/29555236/connectivity-based-segmentation-of-the-brainstem-by-probabilistic-tractography
#10
Adrienn Máté, Dávid Kis, Andrea Czigner, Tamás Fischer, László Halász, Pál Barzó
Diffusion magnetic resonance imaging is a non-invasive tool increasingly used for the investigation of brain connectivity in vivo. In this paper we propose a method that allows segmentation of the brainstem to four subregions (frontopontine, motor, sensory, and reticular) based on connections to supratentorial structures, thereby eliminating the need for using anatomical landmarks within the brainstem for the identification of these subregions. The feasibility of connectivity-based brainstem segmentation was investigated in a group of healthy subjects (n =20)...
March 16, 2018: Brain Research
https://www.readbyqxmd.com/read/29537348/ethics-of-liver-transplantation-the-role-of-the-anesthesiologist
#11
James M West
Anesthesiologists have clearly established their place in the history of medical ethics. Our involvement goes back to 1966 when Henri Beecher published his landmark paper on research and informed consent. Participation in the ethics of transplantation is no less important than our previous work. Organ transplant has been life saving for many but also has given rise to many misunderstandings not just from the public but also among our own colleagues. These include methods of allocation and donation, the role that affluence may play in receiving an organ, the definition of death and donation after circulatory death...
March 1, 2018: Seminars in Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29527138/intrinsic-3d-dynamic-surface-tracking-based-on-dynamic-ricci-flow-and-teichm%C3%A3-ller-map
#12
Xiaokang Yu, Na Lei, Yalin Wang, Xianfeng Gu
3D dynamic surface tracking is an important research problem and plays a vital role in many computer vision and medical imaging applications. However, it is still challenging to efficiently register surface sequences which has large deformations and strong noise. In this paper, we propose a novel automatic method for non-rigid 3D dynamic surface tracking with surface Ricci flow and Teichmüller map methods. According to quasi-conformal Teichmüller theory, the Techmüller map minimizes the maximal dilation so that our method is able to automatically register surfaces with large deformations...
October 2017: Proceedings
https://www.readbyqxmd.com/read/29526043/spinal-cord-stimulation-clinical-efficacy-and-potential-mechanisms
#13
REVIEW
Andrei D Sdrulla, Yun Guan, Srinivasa N Raja
The field of spinal cord stimulation (SCS) owes its inception to the concept of gate control theory (GCT), put forth by Wall and Melzack in their landmark 1965 paper, which proposed that "control of pain may be achieved by selectively activating the large, rapidly conducting fibers". The first reported clinical application of dorsal column stimulation came 2 years later, and the field has gradually expanded ever since. Today, an estimated 50,000 spinal cord neurostimulators are implanted annually...
March 11, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29525379/average-middle-ear-frequency-response-curves-with-preservation-of-curve-morphology-characteristics
#14
Kilian Gladiné, Joris J J Dirckx
For the validation of modelling results or the comparison of middle ear interventions, such as prostheses placement, average responses of middle ear vibrations are needed. One such response is the amplitude and phase of the vibration of the stapes footplate as a function of frequency. Average responses and their standard deviation are commonly obtained by calculating the mean of a number of measured responses at each frequency. A typical middle ear magnitude response curve shows a number of distinct peaks, and the location of these peaks varies between ears...
February 24, 2018: Hearing Research
https://www.readbyqxmd.com/read/29523911/a-new-anatomical-insight-into-the-aetiology-of-lateral-trunk-of-suprascapular-nerve-neuropathy-isolated-infraspinatus-atrophy
#15
Anna Fabis-Strobin, Miroslaw Topol, Jaroslaw Fabis, Kryspin Niedzielski, Michal Podgorski, Lukasz Strobin, Michal Polguj
INTRODUCTION: Although the pathomechanism of isolated infraspinatus atrophy (ISA) in throwing sports is known to be traction, it is unclear why only some players are affected. One likely explanation is that the infraspinatus pulling force exerted by its contracture generate the compressive resultant component force (Fn) compressing the lateral trunk of the suprascapular nerve (LTSN) against the edge of scapular spine. This paper makes two key assumptions (1) the course of LTSN in relation to the scapular spine, defined as the suprascapular-scapular spine angle (SSSA) is the key individual anatomical feature influencing the Fn magnitude, and thus potentially ISA development (2) SSSA is correlated with scapular notch type...
March 9, 2018: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29502032/the-decomposition-of-deformation-new-metrics-to-enhance-shape-analysis-in-medical-imaging
#16
Valerio Varano, Paolo Piras, Stefano Gabriele, Luciano Teresi, Paola Nardinocchi, Ian L Dryden, Concetta Torromeo, Paolo E Puddu
In landmarks-based Shape Analysis size is measured, in most cases, with Centroid Size. Changes in shape are decomposed in affine and non affine components. Furthermore the non affine component can be in turn decomposed in a series of local deformations (partial warps). If the extent of deformation between two shapes is small, the difference between Centroid Size and m-Volume increment is barely appreciable. In medical imaging applied to soft tissues bodies can undergo very large deformations, involving large changes in size...
February 21, 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/29499771/the-memory-map-of-visual-space
#17
Román Rossi-Pool, José Vergara, Ranulfo Romo
A 1989 paper by Patricia Goldman-Rakic and colleagues reported that the prefrontal cortex coded the visual space during working memory. This landmark work not only offered a biological explanation for this cognitive function, but also opened up a wide field of research aimed at understanding the biological bases of various cognitive functions.
March 2018: Trends in Neurosciences
https://www.readbyqxmd.com/read/29483239/how-the-science-of-injury-prevention-contributes-to-advancing-home-fire-safety-in-the-usa-successes-and-opportunities
#18
Andrea C Gielen, Shannon Frattaroli, Keshia M Pollack, Corinne Peek-Asa, Jingzhen G Yang
BACKGROUND: In the decades since the landmark report-America Burning-was published in 1973, the number of home fire deaths has shrunk from >5500 per year to 2650 in 2015. This paper: (1) describes how science and practice in injury prevention and fire and life safety contributed to successful interventions, and (2) identifies emerging strategies and future opportunities to prevent home fire-related deaths. METHODS: The aims are addressed through the lens of population health research, with a focus on the work of selected Centers for Disease Control and Prevention-funded Injury Control Research Centers...
February 26, 2018: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/29477432/fast-modified-self-organizing-deformable-model-geometrical-feature-preserving-mapping-of-organ-models-onto-target-surfaces-with-various-shapes-and-topologies
#19
Shoko Miyauchi, Ken'ichi Morooka, Tokuo Tsuji, Yasushi Miyagi, Takaichi Fukuda, Ryo Kurazume
BACKGROUND AND OBJECTIVE: This paper proposes a new method for mapping surface models of human organs onto target surfaces with the same genus as the organs. METHODS: In the proposed method, called modified Self-organizing Deformable Model (mSDM), the mapping problem is formulated as the minimization of an objective function which is defined as the weighted linear combination of four energy functions: model fitness, foldover-free, landmark mapping accuracy, and geometrical feature preservation...
April 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29465110/james-craufurd-gregory-19th-century-scottish-physicians-and-the-link-between-occupation-as-a-coal-miner-and-lung-disease
#20
K Donaldson, W A Wallace, T A Elliot, C Henry
By the mid-19th century about 200,000 miners were employed in a UK coal mining industry still growing with the advances of the Industrial Revolution. Coal miners were long known to suffer poor health but the link to inhaling dust in the mines had not been made. In 1813 George Pearson was the first to suggest that darkening of lungs seen in normal individuals as they aged was caused by inhaled soot from burning oil, candles and coal, which were the common domestic sources of heat and light. In 1831 Dr James Craufurd Gregory first described black pigmentation and disease in the lungs of a deceased coal miner and linked this to pulmonary accumulation of coal mine dust...
September 2017: Journal of the Royal College of Physicians of Edinburgh
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