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Michael Linecker, Tanja Krones, Thomas Berg, Claus U Niemann, Randolph H Steadman, Philipp Dutkowski, Pierre-Alain Clavien, Ronald W Busuttil, Robert D Truog, Henrik Petrowsky
Liver transplantation has emerged as a highly efficient treatment for a variety of acute and chronic liver diseases. However, organ shortage is becoming an increasing problem globally, limiting the applicability of liver transplantation. In addition, potential recipients are becoming sicker, thereby increasing the risk of losing the graft during transplantation or in the initial postoperative period after liver transplantation (three months). This trend is challenging the model for end-stage liver disease allocation system, where the sickest candidates are prioritised and no delisting criteria are given...
November 11, 2017: Journal of Hepatology
Shahnaz Razavi, Nazem Ghasemi, Mohammad Mardani, Hossein Salehi
OBJECTIVES: Neurotrophic factors secreting cells (NTS-SCs) may be a superior cell source for cell-based therapy in neurodegenerative diseases. NTS-SCs are able to secrete some neurotrophic Such as nerve growth factor and glia-derived neurotrophic factor. Our primary aim was to assess transplantation of neurotrophic factor secreting cells derived from human adipose-derived stem cells (hADSCs) into the damaged spinal cord rats and determine the potential of these cells in remyelination...
April 2017: Iranian Journal of Basic Medical Sciences
Annelise Cocco, Sara Shahrestani, Nicholas Cocco, Ahmer Hameed, Lawrence Yuen, Brendan Ryan, Wayne Hawthorne, Vincent Lam, Henry Pleass
BACKGROUND: Dual kidney transplantation (DKT) was developed to improve outcomes from transplantation of extended criteria donors (ECD). This study examined which surgical techniques have been reported for DKT and whether any technique had superior patient and graft survival. METHOD: Electronic databases were searched for published studies mapping to MESH terms: "kidney or renal" AND "transplan*" AND "dual or double." Single case reports, studies of patients less than 18 years old, studies which did not describe the surgical technique, and studies that did not report patient or graft survival were excluded...
August 2017: Clinical Transplantation
Shameen Salam, Robert Kotloff, Puneet Garcha, Sudhir Krishnan, Dhruv Joshi, Patrick Grady, Abhijit Duggal
Veno-venous extracorporeal membrane oxygenation (ECMO) has become a viable and increasingly utilized option for the treatment of refractory hypoxemia in severe acute respiratory distress syndrome (ARDS). However, options are limited for ARDS patients who fail to wean from ECMO. The high rates of infection, presence of extrapulmonary end organ damage, ICU-acquired weakness, and high short-term mortality associated with ARDS are all significant hurdles that make lung transplantation a difficult prospect to consider...
September 22, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Małgorzata Kościelska, Paweł Żebrowski
Acute kidney injury (AKI) is a common complication in liver transplant recipients. Affecting ~25% of patients preoperatively, and up to 60% postoperatively significantly worsens the prognosis. Etiology differs depending on the time of its onset, from mostly prerenal before the transplantation, ischemic in the early postoperative period to toxic AKI later on. Liver transplantation is a lenghty and complex procedure with a significant risk of hemodynamic instability, metabolic acidosis and electrolyte disturbances...
2015: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Qiu-hua Cai, Jin-xiang Zuo, Zhong-huan Li, Ya-ping Zhang, Yong-gang Zhao, Qiao Deng, Jin Ouyang, Jun-jie Huang, Lu Yu, Jian Zou, Zheng-xiong Zhao
Field experiments were conducted in Shilin and Xundian respectively to study the diffe- rence of rhizosphere microbe quantity and functional diversity with plate culture method and Biolog technique among Hongda (high susceptibility, S), Yun87 (middle resistance, MR) and K326 (high resistance, R) , three flue-cured tobacco cultivars with different resistance to bacterial wilt and black shank. The results indicated that the amounts of bacteria, actinomycetes and the total number of microbes in tobacco plants' rhizosphere were positively correlated with the cultivar' s re- sistance, while it was opposite for the fungi...
December 2015: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Gemma Dyer, Nicole Gilroy, Louisa Brown, Megan Hogg, Lisa Brice, Masura Kabir, Matt Greenwood, Stephen R Larsen, John Moore, Mark Hertzberg, John Kwan, Gillian Huang, Jeff Tan, Christopher Ward, Ian Kerridge
Four hundred forty-one adult allogeneic blood and marrow transplantation (BMT) survivors participated in a cross-sectional survey to assess long-term follow-up (LTFU) model of care preference. Survey instruments included the Sydney Post BMT Survey, Functional Assessment of Cancer Therapy-BMT, Depression Anxiety Stress Scales 21, the Chronic GVHD Activity Assessment-Patient Self Report (Form B), the Lee Chronic GVHD Symptom Scale and the Post-Traumatic Growth Inventory. We found most BMT survivors (74%) would prefer LTFU with their transplantation physicians alone or in combination with transplantation center-linked services (satellite clinics or telemedicine) Over one-quarter indicated a preference for receiving comprehensive post-transplantation care in a "satellite" clinic staffed by their BMT team situated closer to their place of residence, with higher income, higher educational level, and sexual morbidity being significant social factors influencing this preference...
April 2016: Biology of Blood and Marrow Transplantation
Li Zhang, Jing Yang, Yan-Ming Tian, Hui Guo, Yi Zhang
As human umbilical cord mesenchymal stem cells (hUC-MSCs) transplanation may be promising in heart failure treatment, it is important to know whether hypoxic preconditioning (HP) promote hUC-MSCs proliferation and differentiation and protect them against chemical hypoxic damages. This study aimed to investigate the effects of HP on proliferation and differentiation of human umbilical cord mesenchymal stem cells (hUC-MSCs). The study also aimed to confirm our hypothesis that HP could promote hUC-MSCs proliferation and differentiation to cardiomyocyte-like cells as well as effectively protecting hUC-MSCs and cardiomyocyte-like cells against chemical hypoxic damages...
October 31, 2015: Chinese Journal of Physiology
Umesh Lingaraj, Mahesha Vankalakunti, Hemachandar Radhakrishnan, C G Sreedhara, Sunil Rajanna
We report a rare case of primary renal allograft dysfunction due to myeloma cast nephropathy in a patient with no overt clinical features of multiple myeloma preceding his transplantation. A 45-year-old man on hemodialysis for six months for end-stage kidney disease due to presumed chronic glomerulonephritis developed immediate graft dysfunction post-transplantation. The graft biopsy was diagnostic of myeloma cast nephropathy. Other criteria for lambda light chain multiple myeloma were fulfilled with immunofixation electrophoresis and bone marrow biopsy...
September 2015: Saudi Journal of Kidney Diseases and Transplantation
Birgit Kortus-Götze, Joachim Hoyer
We report the first case of a 32-year-old woman with Muckle-Wells syndrome and biopsy-proven systemic AA amyloidosis and end-stage renal disease. She was treated with canakinumab 150 mg subcutaneously every 8 weeks and underwent renal transplantation. Fourteen months after renal transplanation, the patient had no flares of Muckle-Wells syndrome and no evidence of amyloidosis in the renal transplant under an excellent graft function and therapy with canakinumab.
December 2011: NDT Plus
(no author information available yet)
In 14 patients with cirrhosis and portal hypertention autologous mesenclyme multipotential stem cells (AMMSC) transplanation was performed in portal vein (I group, n=7) and common trunk of the hepatic artery (II group, n=6). Duration of pathological processes since diagnosis is 1-8 years (3,7±2,4 years). The initial severity was evaluated by a set of child-Pugh score: Class A - 6 (42,9%), Class B - 8 (57,1%). Cell cultures indentication and characteristics consistent with International Society of cell technology guidanes (ISCT) since 2006...
September 2014: Georgian Medical News
Flavio Ribichini, Giuseppe Faggian, Gabriele Pesarini, Aldo Milano, Leonardo Gottin, Corrado Vassanelli
Left ventricular assistance with surgically implanted pump devices like the HeartMate may be crucial in selected patient with end-stage heart failure. However, mainly due to its high aortic output, the pump itself may induce severe aortic regurgitation that could result in paradoxycal worsening of the anterograde perfusion after the initiation of the support. Surgical or percutaneous occlusion of the aortic valve has proved useful in these kinds of patients. Here we present a successful case of bail-out CoreValve implantation after HeartMate II positioning complicated by acute severe aortic regurgitation in a patient with a failing homograft and end-stage ventricular dysfunction, ineligible for heart transplanation...
July 2014: Cardiovascular Revascularization Medicine: Including Molecular Interventions
S He, T Song, L Xie, L Fu, Z Huang, T Lin
OBJECTIVE: This study evaluated the safety and efficacy of Stilamin (Somatostatin) in the treatment of lymphatic leaks after living-related renal transplanatation. METHODS: Twenty-four patients with lymphatic leaks after kidney transplantation were recruited. All patients were treated with Stilamin and the drainage recorded. RESULTS: The incidence of lymphatic leaks after kidney transplantation was 3.5% usually occurring in 3-9 days after operation...
November 2013: Transplantation Proceedings
Ningfei An, Michael G Janech, Alison M Bland, John Lazarchick, John M Arthur, Yubin Kang
Hematopoiesis is regulated by the bone marrow (BM) niche microenvironment. We recently found that posttransplant administration of AMD3100 (a specific and reversible CXCR4 antagonist) enhanced donor cell engraftment and promoted recovery of all donor cell lineages in a congeneic mouse transplant model. We hypothesized that AMD3100 enhances donor cell reconstitution in part by modulating the levels and constitution of soluble factors in the niche microenvironment. In the current study, the effects of the BM extracellular fluid (supernatant) from AMD3100-treated transplant recipient mice on colony-forming units (CFUs) were examined...
November 2013: Experimental Hematology
Xing Li, Da-Xiang Wen, Yan-Hong Zhao, Yan-Nan Hang, M Susan Mandell
BACKGROUND: Postoperative cognitive dysfunction (POCD) is an adverse condition characterized by declined cognitive functions following surgeries and anesthesia. POCD has been associated with increased hospital stay and mortality. There are histological similarities to Alzheimer's disease. Most early studies were conducted in patients receiving cardiac surgery. Since there is no information about POCD in liver transplant recipients, we measured the incidence of POCD in patients after liver transplantation and examined the correlation between neurological dysfunction and biological markers of dementia-based diseases...
August 2013: Hepatobiliary & Pancreatic Diseases International: HBPD INT
Shu-ichi Ikeda
No abstract text is available yet for this article.
March 10, 2013: Nihon Naika Gakkai Zasshi. the Journal of the Japanese Society of Internal Medicine
Hirotaka Takasaki, Chizuko Hashimoto, Atsuko Fujita, Kenji Matsumoto, Jun Taguchi, Hideyuki Kuwabara, Etsuko Yamazaki, Hideyuki Koharazawa, Hiroyuki Fujita, Shin Fujisawa, Yoshimi Ishii, Wataru Yamamoto, Shigeki Motomura, Naoto Tomita, Yoshiaki Ishigatsubo, Rika Sakai
BACKGROUND: Although rituximab added to CHOP (cyclophosphamide/doxorubicin/vincristine/prednisone) is the standard chemotherapy for untreated DLBCL, its therapeutic effect is limited in younger patients with high-intermediate risk or high-risk disease according to the age-adjusted international prognostic index. In fact, the efficacy and safety of HDT plus rituximab followed by ASCT for such patients remain unclear. PATIENTS AND METHODS: We retrospectively investigated the safety and effectiveness of HDT/ASCT in patients with untreated DLBCL...
August 2013: Clinical Lymphoma, Myeloma & Leukemia
A Tuzuner, F Çakir, C Akyol, Z K Çelebi, S Ceylaner, G Ceylaner, S Sengül, K Keven
The risk of renal transplanation patients developing de novo malignancy is increased 100-fold compared with the healthy nontransplantation population. Renal cell carcinoma (RCC) arising from native kidneys is diagnosed among up to 4.6% of the renal transplant recipients as a consequence of immunosuppression. These tumors tend to behave more aggressively.(1) Although tumors occurring in allografted kidneys can be treated by partial (to save functional graft) or total nephrectomy, there is a paucity of data the outcomes...
April 2013: Transplantation Proceedings
Harvey Ho, Keagan Sorrell, Adam Bartlett, Peter Hunter
In this paper we present a hybrid OD-3D modeling method to investigate the hepatic flow in a virtual right lobe hepatectomy (RLH), the surgical procedure for adult-to-adult living donor liver transplanation (LDLT). The 3D method is employed to simulate complex 3D flow in the portal vein, and the OD model is used to study the systemic hepatic circulation. In particular, we quantify the flow velocity and wall shear stress (WSS) in the left portal vein which increase dramatically post-RLH, and also simulate the essential hepatic distribution features in a healthy adult pre- and post-procedure...
2012: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
Michael D Kluger, James V Guarrera, Sonja K Olsen, Robert S Brown, Jean C Emond, Daniel Cherqui
BACKGROUND: ABO-incompatible organ transplantation typically induces hyperacute rejection. A2-to-O liver transplantations have been successful. This study compared overall and graft survival in O recipients of A2 and O grafts based on Organ Procurement and Transplantation Network data. METHODS: Scientific Registry of Transplant Recipients data were used. The first A2-to-O liver transplantation was entered on March 11, 1990; all previous transplantations were excluded...
September 15, 2012: Transplantation
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