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Vestibular schwannoma

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https://www.readbyqxmd.com/read/28725513/facial-nerve-schwannomas-mimicking-as-vestibular-schwannomas
#1
Beth N McNulty, Sean Wise, David S Cohen, Jason Bell, Dennis Bojrab, Michael LaRouere, Matthew Kircher, Seilesh Babu
Objective  The objective of this study was to identify preoperative and intraoperative findings that may aid in distinguishing facial nerve schwannomas (FNS) from vestibular schwannomas (VSs), particularly in cases limited to the internal auditory canal (IAC) and cerebellopontine angle (CPA). Study Design  This was a retrospective study. Setting  This study was set at a Tertiary Referral Center. Patients  Seventeen cases from October 2002 to July 2015 with an IAC/CPA mass presumed to be a VS who were found to have a FNS intraoperatively...
August 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28723594/cochlear-implantation-improves-hearing-and-vertigo-in-patients-after-removal-of-vestibular-schwannoma
#2
Ariane Roemer, Thomas Lenarz, Anke Lesinski-Schiedat
OBJECTIVES: With rising quality of speech perception in cochlear implant users, the indication widens. Nowadays, cochlear implantation is reasonable even in vestibular schwannoma patients. Speech perception with a cochlear implant is in these patients as promising as in patients with sensorineural hearing loss. However, the impact of cochlear implantation on vertigo and tinnitus after removal of vestibular schwannoma has not been investigated yet. METHODS: In a retrospective study, we analysed 12 patients treated with a cochlear implant after removal of vestibular schwannoma...
June 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/28722232/rapidly-growing-cystic-vestibular-schwannoma-with-sudden-onset-facial-palsy-ten-years-after-subtotal-excision
#3
Manjunath Dandinarasaiah, Golda Grinblat, Sampath Chandra Prasad, Abdelkader Taibah, Mario Sanna
An elderly male patient diagnosed with a right-sided cystic vestibular schwannoma (CVS) at our center underwent a translabyrinthine approach with a subtotal excision to preserve the facial nerve (FN). The tumor grew slowly for the first 9 years but in the subsequent 2 years grew rapidly, with the patient developing a FN paralysis. Using the previous approach, a second surgery was done and the tumor was excised, leaving behind a sheath of tumor on the facial and lower cranial nerves. This case demonstrates that CVSs show unpredictable growth patterns and need to be followed up for a longer period of time...
July 19, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28710469/differential-nf2-gene-status-in-sporadic-vestibular-schwannomas-and-its-prognostic-impact-on-tumour-growth-patterns
#4
Hongsai Chen, Lu Xue, Hantao Wang, Zhaoyan Wang, Hao Wu
The great majority of sporadic vestibular schwannomas (VSs) are due to the inactivation of the NF2 gene. In this study, we found age-dependent differences in the clinical parameters of sporadic VSs. Young patients were characterized by progressive tumour behaviours, including earlier onset of initial symptoms, shorter symptom duration and larger tumour size. An increased rate of "two-hits" of both NF2 alleles, usually by mutation and allelic loss, was observed in young cases compared to older, and this correlated with the loss of protein and mRNA expression...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28707997/gamma-knife-radiosurgery-for-large-vestibular-schwannomas-greater-than-3-cm-in-diameter
#5
Cheng-Wei Huang, Hsien-Tang Tu, Chun-Yi Chuang, Cheng-Siu Chang, Hsi-Hsien Chou, Ming-Tsung Lee, Chuan-Fu Huang
OBJECTIVE Stereotactic radiosurgery (SRS) is an important alternative management option for patients with small- and medium-sized vestibular schwannomas (VSs). Its use in the treatment of large tumors, however, is still being debated. The authors reviewed their recent experience to assess the potential role of SRS in larger-sized VSs. METHODS Between 2000 and 2014, 35 patients with large VSs, defined as having both a single dimension > 3 cm and a volume > 10 cm(3), underwent Gamma Knife radiosurgery (GKRS)...
July 14, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28706761/rapidly-fatal-radiation-induced-glioblastoma
#6
Ivy Ng, Char Loo Tan, Tseng Tsai Yeo, Balamurugan Vellayappan
Glioblastoma (GBM) typically occurs as a primary tumour (i.e., primary GBM) and predominantly affects elderly patients. The remaining ~10% occur as a result of malignant progression from lower grade astrocytic tumours (i.e., secondary GBM). Although there are no certain causative environmental agents, prior radiation exposure may play a role. We report on a patient who had been treated six years prior for a vestibular schwannoma with high-dose conventional radiotherapy and subsequently developed a rapidly fatal glioblastoma at the same location...
June 11, 2017: Curēus
https://www.readbyqxmd.com/read/28699040/-neuroprotective-medication-in-vestibular-schwannoma-surgery
#7
REVIEW
C Scheller, E Herzfeld, C Strauss
BACKGROUND: Except for glucocorticoids there is a lack of neuroprotective medication in neurosurgical interventions. OBJECTIVE: An overview of clinical trials investigating administration of the calcium antagonist nimodipine and hydroxyethyl starch (HES) in vestibular schwannoma (VS) surgery is given. Basic research is addressed and potential neuroprotective effect mechanisms are discussed, as are perspectives for application of the concept to other types of surgery with a risk postoperative impairment of nerve function...
July 11, 2017: HNO
https://www.readbyqxmd.com/read/28692590/vestibular-schwannoma-growth-with-aspirin-and-other-nonsteroidal-anti-inflammatory-drugs
#8
Jacob B Hunter, Brendan P O'Connell, George B Wanna, Marc L Bennett, Alejandro Rivas, Reid C Thompson, David S Haynes
OBJECTIVE: To investigate whether the use of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) impact the growth of vestibular schwannoma (VS). STUDY DESIGN: Retrospective case series. SETTING: Single academic, tertiary care center. PATIENTS: Patients with VS who underwent at least two magnetic resonance imaging (MRI) studies before intervention. INTERVENTION(S): Serial MRI studies...
July 7, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28687471/does-the-postural-variable-affect-the-determination-of-balance-compensation-level-in-vestibular-schwannoma-patients
#9
Julien Frère, Charles P Hoffmann, Gérome C Gauchard, Cécile Parietti-Winkler
Previous sensory organization test (SOT) outcomes provided evidences that the vestibular schwannoma (VS) removal led to acute and slow changes in the ability to use vestibular cues for balance control. However, the assumptions behind the equilibrium score (ES) are somewhat controversial within the literature. Therefore, we compared the time-course of balance control in eighteen VS patients across different postural variables. Analyses of variance and unsupervised clustering (k-means) were used to compare the whole dataset of four postural variables: ES, a modified ES which factored in the time before a fall (cES), the mean amplitude (MA) and the mean velocity (MV) of center of pressure displacements...
July 4, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28674732/preservation-of-hearing-following-awake-surgery-via-the-retrosigmoid-approach-for-vestibular-schwannomas-in-eight-consecutive-patients
#10
Nobusada Shinoura, Akira Midorikawa, Kentaro Hiromitsu, Shoko Saito, Ryoji Yamada
BACKGROUND: Hearing preservation in patients with vestibular schwannomas remains difficult by microsurgery or radiosurgery. METHOD: In this study, awake surgery via the retrosigmoid approach was performed for vestibular schwannomas (volume, 11.6 ± 11.2 ml; range, 1.3-26.4 ml) in eight consecutive patients with preoperative quartering of pure tone audiometry (PTA) of 53 ± 27 dB. RESULTS: After surgery, hearing was preserved in seven patients and improved in one patient...
July 3, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28665390/-surgical-treatment-of-acoustic-neuromas-vestibular-schwannomas
#11
V N Shimanskiy, S V Tanyashin, K V Shevchenko, D A Odamanov
Clinical guidelines are topical systematically developed provisions designed to help the doctor make a decision about a treatment approach in certain clinical situations; they provide information on conducting diagnostic and screening tests, the amount of medical and surgical care, and other aspects of clinical practice. Vestibular schwannomas account for 8% of all intracranial lesions, up to 30% of posterior cranial fossa tumors, and 85% of cerebellopontine angle tumors. The incidence rate of acoustic neuromas is approximately 1 case per 100000 population per year...
2017: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/28664238/intralabyrinthine-schwannomas-surgical-management-and-hearing-rehabilitation-with-cochlear-implants
#12
S K Plontke, T Rahne, M Pfister, G Götze, C Heider, N Pazaitis, C Strauss, P Caye-Thomasen, S Kösling
Intralabyrinthine schwannomas (ILS) are a rare differential diagnosis of sudden hearing loss and vertigo. In an own case series of 12 patients, 6 tumors showed an intracochlear, 3 an intravestibular, 1 a transmodiolar including the cerebellopontine angle (CPA), 1a transotic including the CPA, and 1 a multilocular location. The tumors were removed surgically in 9 patients, whereas 3 patients decided for a "wait-and-test-and-scan" strategy. Of the surgical patients, 3 underwent labyrinthectomy and cochlear implant (CI) surgery in a single-stage procedure; 1 patient had extended cochleostomy with CI surgery; 3 underwent partial or subtotal cochleoectomy, with partial cochlear reconstruction and CI surgery (n = 1) or implantation of electrode dummies for possible later CI after repeated MRI follow-up (n = 2); and in 2 patients, the tumors of the internal auditory canal and cerebellopontine angle exhibiting transmodiolar or transmacular growth were removed by combined translabyrinthine-transotic resection...
June 29, 2017: HNO
https://www.readbyqxmd.com/read/28654042/a-unified-methodological-framework-for-vestibular-schwannoma-research
#13
Lukas D Landegger, Jessica E Sagers, Sonam Dilwali, Takeshi Fujita, Mehmet I Sahin, Konstantina M Stankovic
Vestibular schwannomas are the most common neoplasms of the cerebellopontine angle, making up 6-8% percent of all intracranial growths. Though these tumors cause sensorineural hearing loss in up to 95% of affected individuals, the molecular mechanisms underlying this hearing loss remain elusive. This article outlines the steps established in our laboratory to facilitate the collection and processing of various primary human tissue samples for downstream research applications integral to the study of vestibular schwannomas...
June 20, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28652945/spontaneous-intracranial-hypotension-after-vestibular-schwannoma-resection-due-to-an-unexpected-pathology-tarlov-cysts
#14
Seth E Pross, Jeffrey D Sharon, Michael Lim, Abhay Moghekar, Aruna Rao, John P Carey
While infrequent, cerebrospinal fluid (CSF) leaks are known to occur after surgical resection of vestibular schwannomas. Early signs of CSF leak often include headache and altered mental status. If untreated, life-threatening complications can occur, including brainstem herniation and meningitis. The appropriate surgical treatment for a CSF leak requires accurate localization of the source. While the most likely location of a CSF leak after lateral skull base surgery is through the aerated portions of the temporal bone, we present a unique case of a man with a prolonged CSF leak after an acoustic tumor removal who was ultimately found to have an occult spinal perineural (Tarlov) cyst as the source...
May 19, 2017: Curēus
https://www.readbyqxmd.com/read/28650602/intraoperative-neurophysiological-monitoring-to-protect-the-facial-nerve-during-microsurgery-for-large-vestibular-schwannomas
#15
(no author information available yet)
OBJECTIVE: Microsurgery is the preferred treatment for large vestibular schwannomas (VSs). However, anatomical and functional preservation of the facial nerve (FN) remains a challenge during this surgery. The aim of this study was to determine whether it is beneficial to the preservation rates of the FN during microsurgical treatment of large VSs using intraoperative neurophysiological monitoring (IONM). METHODS: We retrospectively reviewed 53 patients with large VSs that underwent microsurgical resection via the retrosigmoid approach in our department during April 2009 to March 2016...
May 26, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28647663/management-of-residual-tumor-after-limited-subtotal-resection-of-large-vestibular-schwannomas-lessons-learned-and-a-rationale-for-specialized-care
#16
William R Copeland, Matthew L Carlson, Brian A Neff, Colin L W Driscoll, Michael J Link
BACKGROUND: In an era where subtotal resection (STR) is increasingly utilized, we have encountered a growing number of patients referred to our institution with limited resection of large vestibular schwannomas (VS), at times associated with grave complications. OBJECTIVE: We highlight lessons learned in the management of large VS and provide a rationale for specialized care. METHODS: A prospectively maintained database of over 2,000 patients with VS evaluated at our institution between 2000 and 2016 was reviewed...
June 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28640700/cns-tumors-in-neurofibromatosis
#17
Jian Campian, David H Gutmann
Neurofibromatosis (NF) encompasses a group of distinct genetic disorders in which affected children and adults are prone to the development of benign and malignant tumors of the nervous system. The purpose of this review is to discuss the spectrum of CNS tumors arising in individuals with NF type 1 (NF1) and NF type 2 (NF2), their pathogenic etiologies, and the rational treatment options for people with these neoplasms. This article is a review of preclinical and clinical data focused on the treatment of the most common CNS tumors encountered in children and adults with NF1 and NF2...
July 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28633510/in-reply-stereotactic-radiosurgery-for-cystic-vestibular-schwannomas
#18
Michael J Link
No abstract text is available yet for this article.
June 17, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28633492/letter-stereotactic-radiosurgery-for-cystic-vestibular-schwannomas
#19
Eduardo de Arnaldo Silva Vellutini, Matheus Fernandes de Oliveira
No abstract text is available yet for this article.
June 17, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28633408/risk-factors-for-readmission-with-cerebrospinal-fluid-leakage-within-30-d-of-vestibular-schwannoma-surgery
#20
Ali A Alattar, Brian R Hirshman, Brandon A McCutcheon, Clark C Chen, Thomas Alexander, Jeffrey Harris, Bob S Carter
BACKGROUND: Cerebrospinal fluid (CSF) leak is a well-recognized complication after surgical resection of vestibular schwannomas and is associated with a number of secondary complications, including readmission and meningitis. OBJECTIVE: To identify risk factors for and timing of 30-d readmission with CSF leak. METHODS: Patients who had undergone surgical resection of a vestibular schwannoma from 1995 to 2010 were identified in the California Office of Statewide Health Planning and Development database...
June 14, 2017: Neurosurgery
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