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Vestibular schwannoma

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https://www.readbyqxmd.com/read/29140965/long-term-hearing-preservation-after-resection-of-vestibular-schwannoma-a-systematic-review-and-meta-analysis
#1
Syed F Ahsan, Farhan Huq, Michael Seidman, Andrew Taylor
OBJECTIVE: The objective is to perform a systematic review and meta-analysis of the literature on the long-term results of hearing preservation after vestibular schwannoma resection. DATA SOURCES: Ovid/Medline, PubMed, Embase, and the Cochrane library from January 1980 to January 2015. STUDY SELECTION: Inclusion criteria: age ≥18 years, minimum 10 patients in the treatment group, hearing preserving microsurgery, no previous radiation treatment, serviceable hearing at immediate postop follow-up, hearing outcomes reported using Gardner Robinson or the American Academy of Otolaryngology-Head and Neck Surgeons hearing grading scales, and average follow-up of 5 years...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29138018/anti-tumor-effects-of-cold-atmospheric-pressure-plasma-on-vestibular-schwannoma-demonstrate-its-feasibility-as-an-intra-operative-adjuvant-treatment
#2
Yeo Jun Yoon, Michelle J Suh, Hyun Young Lee, Hae June Lee, Eun Ha Choi, In Seok Moon, Kiwon Song
Vestibular schwannoma (VS), although a benign intracranial tumor, causes morbidities by brainstem compression. Since chemotherapy is not very effective in most Nf2-negative schwannomas, surgical removal or radiation therapy is required. However, depending on the size and site of the tumor, these approaches may cause loss of auditory or vestibular functions, and severely decrease the post-surgical wellbeing. Here, we examined the feasibility of cold atmospheric pressure plasma (CAP) as an intra-operative adjuvant treatment for VS after surgery...
November 11, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29135868/endoscopic-transcanal-transpromontorial-approach-for-vestibular-schwannoma-resection-a-case-series
#3
Cameron C Wick, Demetri Arnaoutakis, Samuel L Barnett, Alejandro Rivas, Brandon Isaacson
OBJECTIVE: To demonstrate successful surgical management of vestibular schwannomas via an exclusively endoscopic transcanal transpromontorial approach (EETTA). PATIENTS: Four patients with vestibular schwannomas. INTERVENTIONS: Surgical excision via EETTA. MAIN OUTCOMES: Technique refinements, tumor access, complete tumor removal, and patient morbidity. RESULTS: Three tumors were Koos grade I and one tumor was Koos grade II...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29134166/anterior-extension-of-tumor-is-as-important-as-tumor-size-to-facial-nerve-outcome-and-extent-of-resection-for-vestibular-schwannomas
#4
Ricky H Wong, William R Copeland, Jeffrey T Jacob, Sananthan Sivakanthan, Jamie J Van Gompel, Harry van Loveren, Michael J Link, Siviero Agazzi
Objectives  We examined vestibular schwannoma tumor dimension and direction of growth to determine whether these correlate with facial nerve outcome as well as extent of resection (EOR). Design  Retrospective review of prospectively maintained databases. Participants  206 patients were a part of this study. Main Outcome Measures  Tumor dimensions were measured using preoperative magnetic resonance imaging, and a series of ratios were then calculated to further characterize tumor dimension. Regression analyses were performed to investigate correlation with facial nerve outcome and EOR...
December 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29134162/lesions-mimicking-small-vestibular-schwannomas
#5
Matthias Scheich, Rudolf Hagen, Desiree Ehrmann-Müller, Brigitte Bison, Thomas Günthner-Lengsfeld, Camelia-Maria Monoranu, Hans-Ullrich Völker
Objective  Most tumors of the internal auditory canal and cerebellopontine angle (CPA) are vestibular schwannomas (VSs). Preoperative diagnosis is based on typical clinical symptoms and radiological findings. In rare cases, histopathology can, however, show different results. Design  This is a retrospective chart and database review. Setting  The study was conducted at a tertiary skull base referral center at a university hospital. Participants  A total of 207 consecutive cases of VS surgery via the middle cranial fossa approach performed between December 2005 and January 2015 were reviewed...
December 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29129769/retrosigmoid-intradural-suprameatal-inframeatal-approach-for-complete-surgical-removal-of-a-giant-recurrent-vestibular-schwannoma-with-severe-petrous-bone-involvement-technical-case-report
#6
Yosuke Sato, Tohru Mizutani, Katsuyoshi Shimizu, Hans-Joachim Freund, Madjid Samii
BACKGROUND: Surgical removal of giant vestibular schwannomas with severe petrous bone involvement remains challenging due to the high risk of complications. The retrosigmoid intradural suprameatal-inframeatal approach (RISIA) allows for safe exposure extending from Meckel's cave to the petrous internal carotid artery (ICA). CLINICAL DESCRIPTION: A 27-year-old man presented with recurrence of a giant vestibular schwannoma (4.5 cm) invading Meckel's cave and the left petrous ICA...
November 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29116483/pittsburgh-compound-b-pib-pet-imaging-of-meningioma-and-other-intracranial-tumors
#7
Derek R Johnson, Christopher H Hunt, Mark A Nathan, Joseph E Parisi, Bradley F Boeve, Melissa E Murray, David S Knopman, Clifford R Jack, Ronald C Petersen, Val J Lowe, Geoffrey B Johnson
Meningiomas are the most common intracranial tumors. Diagnosis by MRI is generally straightforward, but lack of imaging specificity can present a diagnostic dilemma, particularly in patients with cancer. We report our experience with meningioma identification on Pittsburgh compound B (PiB) PET/CT. Patients who underwent PiB PET/CT from 2006 to 2015 were reviewed to identify those with intracranial tumors. Tumor types were classified by MR appearance, or by pathology when available. Maximum standardized uptake value (SUVmax) measurements of tumor PiB activity were compared across tumor types...
November 8, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29107410/contralateral-trigeminal-neuralgia-in-a-rapidly-growing-vestibular-schwannoma-a-case-report
#8
Youngbeom Seo, Dong Gyu Kim
We present a rare case of vestibular schwannoma (VS) with contralateral trigeminal neuralgia. A 59 year-old woman presented with right-sided trigeminal neuralgia and a small VS in the left cerebellopontine angle (CPA) that was found via magnetic resonance imaging. The patient was administered medication; however, her symptoms gradually aggravated, and the size of the tumor increased. Two years after the initial diagnosis, the patient underwent surgical resection. After surgical resection, the patient's facial pain was improved...
October 26, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29099442/prospective-evaluation-of-patients-undergoing-translabyrinthine-excision-of-vestibular-schwannoma-with-concurrent-cochlear-implantation
#9
Meredith A Rooth, Margaret T Dillon, Kevin D Brown
OBJECTIVE: Translabyrinthine (TL) vestibular schwannoma (VS) resection may be accomplished with preservation of the cochlear nerve, permitting successful, concurrent cochlear implantation. In this single institution, Food and Drug Administration-approved feasibility study, we wished to determine the success and outcomes of concurrent cochlear implantation at the time of TL resection of VS. STUDY DESIGN: Prospective cohort. SETTING: Tertiary referral center...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29098313/-surgery-of-vestibular-schwannoma%C3%A2-more-clinical-diagnostics-of-vertigo-for-a-better-preservation-of-hearing
#10
REVIEW
A Blödow
No abstract text is available yet for this article.
November 2, 2017: HNO
https://www.readbyqxmd.com/read/29095749/genetics-of-vestibular-syndromes
#11
Pablo Roman-Naranjo, Alvaro Gallego-Martinez, Jose A Lopez Escamez
PURPOSE OF REVIEW: The increased availability of next generation sequencing has enabled a rapid progress in the discovery of genetic variants associated with vestibular disorders. We have summarized molecular genetics finding in vestibular syndromes during the last 18 months. RECENT FINDINGS: Genetic studies continue to shed light on the genetic background of vestibular disorders. Novel genes affecting brain development and otolith biogenesis have been associated with motion sickness...
November 1, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29088993/an-update-on-the-diagnosis-and-treatment-of-vestibular-schwannoma
#12
Jane Halliday, Scott A Rutherford, Martin G McCabe, Dafydd G Evans
Vestibular schwannomas (VS) account for approximately 85% of tumors in the cerebello-pontine angle, with a lifetime incidence of approximately 1 in 1000. Most are sporadic, with approximately 5% related to the tumor predisposition syndrome Neurofibromatosis Type 2 (NF2). The mainstays of management strategies are: observation, surgery, radiosurgery/radiotherapy and, for patients with NF2 and rapidly growing tumors or deteriorating neurologic function the targeted therapy bevacizumab. While morbidity and mortality rates related to treatment of VS have improved dramatically over the last decades, there are still significant improvements that could be made, in particular with regards to long-term facial nerve and hearing outcomes...
November 7, 2017: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/29081426/bilateral-vestibulopathy-diagnostic-criteria-consensus-document-of-the-classification-committee-of-the-b%C3%A3-r%C3%A3-ny-society
#13
Michael Strupp, Ji-Soo Kim, Toshihisa Murofushi, Dominik Straumann, Joanna C Jen, Sally M Rosengren, Charles C Della Santina, Herman Kingma
This paper describes the diagnostic criteria for bilateral vestibulopathy (BVP) by the Classification Committee of the Bárány Society. The diagnosis of BVP is based on the patient history, bedside examination and laboratory evaluation. Bilateral vestibulopathy is a chronic vestibular syndrome which is characterized by unsteadiness when walking or standing, which worsen in darkness and/or on uneven ground, or during head motion. Additionally, patients may describe head or body movement-induced blurred vision or oscillopsia...
2017: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/29080147/non-invasive-intraoperative-monitoring-of-cochlear-function-by-cochlear-microphonics-during-cerebellopontine-angle-surgery
#14
Blandine Lourenço, Béatriz Madero, Stéphane Tringali, Xavier Dubernard, Toufic Khalil, André Chays, Arnaud Bazin, Thierry Mom, Paul Avan
In vestibular-schwannoma (VS) surgery, hearing-preservation rate remains low. Besides damage to the cochlear nerve, intraoperative cochlear ischemia is a potential cause of hearing loss. Here, we used non-invasive cochlear microphonic (CM) recordings to detect the cochlear vascular events of VS surgery. Continuous intraoperative CM monitoring, in response to 80-95 dB SPL, 1-kHz tone-bursts, was performed in two samples of patients undergoing retrosigmoid cerebellopontine-angle surgery: one for VS (n = 31) and one for vestibular neurectomy or vasculo-neural conflict causing intractable trigeminal neuralgia, harmless to hearing (n = 19, control group)...
October 27, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29079887/preoperative-determination-of-nerve-of-origin-in-patients-with%C3%A2-vestibular%C3%A2-schwannoma
#15
T Rahne, S Plößl, S K Plontke, C Strauss
BACKGROUND: Vestibular schwannoma (VS) is a benign tumor that develops in the internal auditory canal and the cerebellopontine angle, potentially diminishing hearing or balance. Most VS tumors arise from one of two vestibular branches: the superior or inferior vestibular nerve. Determining the specific nerve of origin could improve patient management in terms of preoperative counseling, treatment selection, and surgical decision-making and planning. The aim of this study was to introduce a novel scoring system that was designed to determine the nerve of origin...
October 27, 2017: HNO
https://www.readbyqxmd.com/read/29069961/factors-affecting-hearing-deterioration-in-vestibular-schwannoma-patients-treated-with-gamma-knife-radiosurgery-the-asan-medical-center-experience
#16
Marn Joon Park, Hong Ju Park, Jong Woo Chung, Do Heui Lee, Young Hyun Cho, Young Jun Choi, Joong Ho Ahn
OBJECTIVES: To investigate the changes in hearing and to determine factors predicting hearing deterioration in patients with vestibular schwannoma (VS) who undergo gamma knife radiosurgery (GKRS). DESIGN: A retrospective review of medical records in patients diagnosed with VS and initially treated with GKRS at a tertiary care medical center between 1995 and 2015 was performed. Tumor factors (location, volume), parameters related to irradiation to the tumor and cochlea, and distance between the tumor and cochlea were reviewed...
October 25, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29066124/population-based-study-of-stereotactic-radiosurgery-or-fractionated-stereotactic-radiation-therapy-for-vestibular-schwannoma-long-term-outcomes-and-toxicities
#17
Andrea Lo, Gareth Ayre, Roy Ma, Fred Hsu, Ryojo Akagami, Michael McKenzie, Boris Valev, Ermias Gete, Isabelle Vallieres, Alan Nichol
PURPOSE: To examine long-term local control of vestibular schwannoma and side effects in patients treated with stereotactic radiosurgery (SRS) and fractionated stereotactic radiation therapy (SRT) in British Columbia. METHODS AND MATERIALS: From August 1998 to May 2009, 207 patients were treated with radiation therapy (RT) at British Columbia Cancer Agency. 136 (66%) received SRS, and 71 (34%) received SRT. Dose prescriptions were 50 Gy/25 fractions for SRT and 12 Gy/1 fraction for SRS...
September 18, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29048255/quality-of-life-in-patients-with-unilateral-vestibular-schwannoma-on-wait-and-see-strategy
#18
P C Klersy, F Arlt, M Hofer, J Meixensberger
OBJECTIVE: A 'wait and see' strategy is an option when managing patients with small vestibular schwannomas (VS). A risk of growth and worsening of hearing may influence a patient's daily quality of life (QOL). Therefore, the present study focused on QOL parameters in patients who are on a 'wait and see' strategy following magnetic resonance imaging (MRI)-based diagnosis of small unilateral VS. PATIENTS AND METHODS: Sixty-five patients (mean age 64.4 years; male:female, 32:33) who suffered from a small unilateral VS (9...
October 19, 2017: Neurological Research
https://www.readbyqxmd.com/read/29036751/-diagnosis-and-management-of-vestibular-schwannomas-an-interdisciplinary-challenge
#19
Steffen Rosahl, Christopher Bohr, Michael Lell, Klaus Hamm, Heinrich Iro
Vestibular schwannomas expand slowly in the internal auditory canal, in the cerebellopontine angle, inside the cochlear and the labyrinth. Larger tumors can displace and compress the brainstem. With an annual incidence of 1:100 000 vestibular schwannoma represent 6-7% of all intracranial tumors. In the cerebellopontine angle they are by far the most neoplasm with 90% of all lesions located in this region. Magnetic resonance imaging (MRI), audiometry, and vestibular diagnostics are the mainstays of the clinical workup for patients harboring tumors...
April 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29018206/tumor-penetrating-delivery-of-sirna-against-tnf%C3%AE-to-human-vestibular-schwannomas
#20
Yin Ren, Jessica E Sagers, Lukas D Landegger, Sangeeta N Bhatia, Konstantina M Stankovic
Vestibular schwannoma (VS) is the most common tumor of the cerebellopontine angle, and it typically presents with sensorineural hearing loss. The genomic landscape of schwannoma is complex and many of the molecules implicated in VS pathogenesis represent targets not amenable to antibody-based or small molecule therapeutics. Tumor-targeted delivery of small interfering RNA (siRNA) therapeutics provides a direct and effective means to interrogate targets while minimizing off-target effects. To establish a preclinical model for therapeutic inhibition of putative targets in VS, archived tumor specimens, fresh tumor cells derived from patients with sporadic VS, and an established schwannoma cell line were screened...
October 10, 2017: Scientific Reports
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