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Vestibular schwannoma

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https://www.readbyqxmd.com/read/28806327/long-term-quality-of-life-following-vestibular-schwannoma-excision-via-the-translabyrinthine-approach
#1
Stephen J Broomfield, Ashish K Mandavia, Jack S Nicholson, Osama Mahmoud, Andrew T King, Scott A Rutherford, Richard T Ramsden
OBJECTIVE: To assess postoperative quality of life (QOL) and other patient-reported outcomes following surgery for vestibular schwannoma. STUDY DESIGN: Cross-sectional retrospective case review using postal questionnaires. SETTING: Tertiary referral center. PATIENTS: Five hundred consecutive patients undergoing surgery for vestibular schwannoma. INTERVENTION(S): Patients undergoing surgery via the translabyrinthine approach (excluding neurofibromatosis type 2) under the senior author, with a minimum of 5 years follow-up, were included...
September 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28799319/ataxia-in-a-young-female
#2
R Jayanthi, K Monica, K Raja, C S Gauthaman, P P Arunkumar
Neurofibromatosis type 2 (NF2) is a genetically inherited disorder characterized by the presence of multiple central nervous system tumours, most pathognomonic being bilateral vestibular schwannomas with or without peripheral manifestations in the form of cataract or cutaneous neurofibromas. NF2 is an uncommon disorder compared to NF1. We describe a classical case of neurofibromatosis type 2 with florid clinical manifestations and characteristic neuroimaging features. We also briefly describe the literature pertaining to this rare disorder...
August 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28796095/intracanalicular-vestibular-schwannomas-initial-clinical-manifestation-imaging-classification-and-risk-stratification-for-management-proposal
#3
Elias Younes, Marion Montava, Mathilde Bachelard-Serra, Laurent Jaloux, Florent Salburgo, Jean Pierre Lavieille
INTRODUCTION: There is no consensus about the use of observation as a therapeutic modality for intracanalicular vestibular schwannoma (ICVS). The objective of this study was to describe tumor evolution, its correlation with initial size, stage of vestibular schwannoma, clinical presentation and to propose a risk classification for tumor growth with a therapeutic decision algorithm. METHODS: Fifty-three patients with ICVS were followed prospectively from 2010 to 2015...
August 8, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28796091/comparing-outcomes-following-salvage-microsurgery-in-vestibular-schwannoma-patients-failing-gamma-knife-radiosurgery-or-microsurgery
#4
Hyun-Jin Lee, Mi Joo Kim, Seung Hyun Koh, Won Seok Chang, In Seok Moon
OBJECTIVE: The increasing use of primary gamma-knife radiosurgery (GKS) for the treatment of vestibular schwannoma (VS) has led to a concomitant increase in the number of patients requiring salvage surgery for GKS failure. When patients underwent GKS as the primary treatment, it is known that dissecting tumor from adjacent nerves during salvage surgery is more difficult. In this report, we share our clinical experience with such patients and analyze the clinical findings of patients with tumor regrowth/recurrence...
August 8, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28781804/schwannoma-of-the-hypoglossal-nerve-review-of-the-literature-based-on-an-illustrative-case
#5
Rosario Fornaro, Alexander Salerno, David Constantin Filip, Elisa Caratto, Michela Caratto, Marco Casaccia
Schwannomas are benign tumours that originate from the myelin sheath of peripheral nerves. They are characterised by a slow growth tendency. Benign schwannomas represent 35% of the head and neck district tumours. Hypoglossal schwannomas account for 5% of non-vestibular schwannomas, and malignant schwannomas occur very rarely. In the present case report, the case of a 49-year-old man who presented with paraesthesias in the left parotid and submandibular region, associated with sensation of foreign bodies and dysphagia for solids, is described...
August 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28775147/combination-therapy-with-c-met-and-src-inhibitors-induces-caspase-dependent-apoptosis-of-merlin-deficient-schwann-cells-and-suppresses-growth-of-schwannoma-cells
#6
Marisa A Fuse, Stephani Klingeman Plati, Sarah S Burns, Christine T Dinh, Olena Bracho, Denise Yan, Rahul Mittal, Rulong Shen, Julia N Soulakova, Alicja J Copik, Xue Zhong Liu, Fred F Telischi, Long-Sheng Chang, Maria Clara Franco, Cristina Fernandez-Valle
Neurofibromatosis type 2 (NF2) is a nervous system tumor disorder caused by inactivation of the merlin tumor suppressor encoded by the NF2 gene. Bilateral vestibular schwannomas (VS) are a diagnostic hallmark of NF2. Mainstream treatment options for NF2-associated tumors have been limited to surgery and radiotherapy; however, off-label uses of targeted molecular therapies are becoming increasingly common. Here we investigated drugs targeting two kinases activated in NF2-associated schwannomas, c-Met and Src...
August 3, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28759666/association-of-genetic-predisposition-with-solitary-schwannoma-or-meningioma-in-children-and-young-adults
#7
Omar N Pathmanaban, Katherine V Sadler, Ian D Kamaly-Asl, Andrew T King, Scott A Rutherford, Charlotte Hammerbeck-Ward, Martin G McCabe, John-Paul Kilday, Christian Beetz, Nicola K Poplawski, D Gareth Evans, Miriam J Smith
Importance: Meningiomas and schwannomas are usually sporadic, isolated tumors occurring in adults older than 60 years and are rare in children and young adults. Multiple schwannomas and/or meningiomas are more frequently associated with a tumor suppressor syndrome and, accordingly, trigger genetic testing, whereas solitary tumors do not. Nevertheless, apparently sporadic tumors in young patients may herald a genetic syndrome. Objective: To determine the frequency of the known heritable meningioma- or schwannoma-predisposing mutations in children and young adults presenting with a solitary meningioma or schwannoma...
July 31, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28755914/cochlear-nerve-action-potential-monitoring-for-preserving-function-of-an-unseen-cochlear-nerve-in-vestibular-schwannoma-surgery
#8
Mami Ishikawa, Atsuhiro Kojima, Satoshi Terao, Mutsumi Nagai, Gen Kusaka, Heiji Naritaka
BACKGROUND: Intraoperative monitoring of cochlear nerve action potential (CNAP) has been used in patients with small vestibular schwannoma (<15 mm) to preserve cochlear nerve function. We performed surgery for a larger vestibular schwannoma under CNAP monitoring and preserved cochlear nerve function, as compared with that in 10 normal patients showing hemifacial spasm. CASE DESCRIPTION: We report the case of a patient with a 26-mm vestibular schwannoma and normal hearing function who underwent neurosurgery under electrophysiological monitoring of the facial and cochlear nerves...
July 26, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28754643/probabilistic-tractography-of-the-cranial-nerves-in-vestibular-schwannoma
#9
Amir Zolal, Tareq A Juratli, Dino Podlesek, Bernhard Rieger, Hagen H Kitzler, Jennifer Linn, Gabriele Schackert, Stephan B Sobottka
OBJECTIVE: Multiple recent studies have reported on diffusion tensor-based fiber tracking of cranial nerves in vestibular schwannoma, with conflicting results as to the accuracy of the method and the occurrence of cochlear nerve depiction. Probabilistic non-tensor based tractography might offer advantages in terms of better extraction of directional information from the underlying data in cranial nerves, which are of sub-voxel size. METHODS: Twenty-one patients with large vestibular schwannomas were recruited...
July 25, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28751138/prognostic-factors-of-hearing-outcome-in-untreated-vestibular-schwannomas-implication-of-subdivision-of-their-growth-by-volumetric-analysis
#10
Jin-Deok Joo, Se Jin Oh, Young-Hoon Kim, Jung Ho Han, Byoung Yoon Choi, Ja-Won Koo, Chae-Yong Kim
BACKGROUND: Conservative wait-and-scan management for vestibular schwannomas (VSs) is an important treatment option, but its role is unclear because of discordance between tumor growth and hearing outcomes. METHODS: The present study was a retrospective analysis of 97 patients with sporadic VSs who were followed-up without treatment between 2003 and 2012. Tumor volume was measured by three-dimensional volumetry at each follow-up visit. The median follow-up duration was 47 months (range, 13-122 months)...
July 24, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28750117/exercise-induced-vertigo-in-vestibular-schwannoma
#11
Emma Foster, Luke Chen
No abstract text is available yet for this article.
July 27, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28737257/unilateral-vestibular-schwannoma-and-meningiomas-in-a-patient-with-pik3ca-related-segmental-overgrowth-co-occurrence-of-mosaicism-for-two-rare-disorders
#12
John R Mills, Ann M Moyer, Benjamin R Kipp, Andrzej B Poplawski, Ludwine M Messiaen, Dusica Babovic-Vuksanovic
A 28-year-old female with PIK3CA-related segmental overgrowth presented with headaches. She also had a unilateral vestibular schwannoma (VS), as well as three small (<2 cm) meningiomas, which according to the Manchester consensus diagnostic criteria for neurofibromatosis 2 (NF2) is sufficient for a clinical diagnosis. Analysis of blood revealed a mosaic PIK3CA c.2740G>A (p.Gly914Arg) mutation, confirming the diagnosis of PIK3CA-related overgrowth, but no mutations in NF2 were detected. Although VS has not previously been reported in PIK3CA-related segmental overgrowth, meningiomas have, raising the question of whether this patient's VS and meningiomas represent coincidental NF2 or phenotypic extension of her overgrowth syndrome...
July 24, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28725513/facial-nerve-schwannomas-mimicking-as-vestibular-schwannomas
#13
Beth N McNulty, Sean Wise, David S Cohen, Jason Bell, Dennis Bojrab, Michael LaRouere, Matthew Kircher, Seilesh Babu
Objective  The objective of this study was to identify preoperative and intraoperative findings that may aid in distinguishing facial nerve schwannomas (FNS) from vestibular schwannomas (VSs), particularly in cases limited to the internal auditory canal (IAC) and cerebellopontine angle (CPA). Study Design  This was a retrospective study. Setting  This study was set at a Tertiary Referral Center. Patients  Seventeen cases from October 2002 to July 2015 with an IAC/CPA mass presumed to be a VS who were found to have a FNS intraoperatively...
August 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28723594/cochlear-implantation-improves-hearing-and-vertigo-in-patients-after-removal-of-vestibular-schwannoma
#14
Ariane Roemer, Thomas Lenarz, Anke Lesinski-Schiedat
OBJECTIVES: With rising quality of speech perception in cochlear implant users, the indication widens. Nowadays, cochlear implantation is reasonable even in vestibular schwannoma patients. Speech perception with a cochlear implant is in these patients as promising as in patients with sensorineural hearing loss. However, the impact of cochlear implantation on vertigo and tinnitus after removal of vestibular schwannoma has not been investigated yet. METHODS: In a retrospective study, we analysed 12 patients treated with a cochlear implant after removal of vestibular schwannoma...
June 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/28722232/rapidly-growing-cystic-vestibular-schwannoma-with-sudden-onset-facial-palsy-ten-years-after-subtotal-excision
#15
Manjunath Dandinarasaiah, Golda Grinblat, Sampath Chandra Prasad, Abdelkader Taibah, Mario Sanna
An elderly male patient diagnosed with a right-sided cystic vestibular schwannoma (CVS) at our center underwent a translabyrinthine approach with a subtotal excision to preserve the facial nerve (FN). The tumor grew slowly for the first 9 years but in the subsequent 2 years grew rapidly, with the patient developing a FN paralysis. Using the previous approach, a second surgery was done and the tumor was excised, leaving behind a sheath of tumor on the facial and lower cranial nerves. This case demonstrates that CVSs show unpredictable growth patterns and need to be followed up for a longer period of time...
July 19, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28710469/differential-nf2-gene-status-in-sporadic-vestibular-schwannomas-and-its-prognostic-impact-on-tumour-growth-patterns
#16
Hongsai Chen, Lu Xue, Hantao Wang, Zhaoyan Wang, Hao Wu
The great majority of sporadic vestibular schwannomas (VSs) are due to the inactivation of the NF2 gene. In this study, we found age-dependent differences in the clinical parameters of sporadic VSs. Young patients were characterized by progressive tumour behaviours, including earlier onset of initial symptoms, shorter symptom duration and larger tumour size. An increased rate of "two-hits" of both NF2 alleles, usually by mutation and allelic loss, was observed in young cases compared to older, and this correlated with the loss of protein and mRNA expression...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28707997/gamma-knife-radiosurgery-for-large-vestibular-schwannomas-greater-than-3-cm-in-diameter
#17
Cheng-Wei Huang, Hsien-Tang Tu, Chun-Yi Chuang, Cheng-Siu Chang, Hsi-Hsien Chou, Ming-Tsung Lee, Chuan-Fu Huang
OBJECTIVE Stereotactic radiosurgery (SRS) is an important alternative management option for patients with small- and medium-sized vestibular schwannomas (VSs). Its use in the treatment of large tumors, however, is still being debated. The authors reviewed their recent experience to assess the potential role of SRS in larger-sized VSs. METHODS Between 2000 and 2014, 35 patients with large VSs, defined as having both a single dimension > 3 cm and a volume > 10 cm(3), underwent Gamma Knife radiosurgery (GKRS)...
July 14, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28706761/rapidly-fatal-radiation-induced-glioblastoma
#18
Ivy Ng, Char Loo Tan, Tseng Tsai Yeo, Balamurugan Vellayappan
Glioblastoma (GBM) typically occurs as a primary tumour (i.e., primary GBM) and predominantly affects elderly patients. The remaining ~10% occur as a result of malignant progression from lower grade astrocytic tumours (i.e., secondary GBM). Although there are no certain causative environmental agents, prior radiation exposure may play a role. We report on a patient who had been treated six years prior for a vestibular schwannoma with high-dose conventional radiotherapy and subsequently developed a rapidly fatal glioblastoma at the same location...
June 11, 2017: Curēus
https://www.readbyqxmd.com/read/28699040/-neuroprotective-medication-in-vestibular-schwannoma-surgery
#19
REVIEW
C Scheller, E Herzfeld, C Strauss
BACKGROUND: Except for glucocorticoids there is a lack of neuroprotective medication in neurosurgical interventions. OBJECTIVE: An overview of clinical trials investigating administration of the calcium antagonist nimodipine and hydroxyethyl starch (HES) in vestibular schwannoma (VS) surgery is given. Basic research is addressed and potential neuroprotective effect mechanisms are discussed, as are perspectives for application of the concept to other types of surgery with a risk postoperative impairment of nerve function...
July 11, 2017: HNO
https://www.readbyqxmd.com/read/28692590/vestibular-schwannoma-growth-with-aspirin-and-other-nonsteroidal-anti-inflammatory-drugs
#20
Jacob B Hunter, Brendan P O'Connell, George B Wanna, Marc L Bennett, Alejandro Rivas, Reid C Thompson, David S Haynes
OBJECTIVE: To investigate whether the use of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) impact the growth of vestibular schwannoma (VS). STUDY DESIGN: Retrospective case series. SETTING: Single academic, tertiary care center. PATIENTS: Patients with VS who underwent at least two magnetic resonance imaging (MRI) studies before intervention. INTERVENTION(S): Serial MRI studies...
September 2017: Otology & Neurotology
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