keyword
MENU ▼
Read by QxMD icon Read
search

beige

keyword
https://www.readbyqxmd.com/read/29793055/fatty-acid-activation-in-thermogenic-adipose-tissue
#1
REVIEW
Sandra Steensels, Baran A Ersoy
Channeling carbohydrates and fatty acids to thermogenic tissues, including brown and beige adipocytes, have garnered interest as an approach for the management of obesity-related metabolic disorders. Mitochondrial fatty acid oxidation (β-oxidation) is crucial for the maintenance of thermogenesis. Upon cellular fatty acid uptake or following lipolysis from triglycerides (TG), fatty acids are esterified to coenzyme A (CoA) to form active acyl-CoA molecules. This enzymatic reaction is essential for their utilization in β-oxidation and thermogenesis...
May 21, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29787512/browning-of-human-subcutaneous-adipose-tissue-after-its-transplantation-in-nude-mice
#2
Lihong Qiu, Zhaoxiang Zhang, Hui Zheng, Shaoheng Xiong, Yingjun Su, Xianjie Ma, Chenggang Yi
BACKGROUND: The clinical unpredictability of autologous fat grafting originates partially from the unique characteristics of adipose tissue. Evidences of adipose remodeling toward browning (developing of brown-like adipocytes in white adipose tissue) in response to trauma are emerging. With regard to fat grafting surgery procedure by which adipose tissue depots are directly and ubiquitously traumatized, whether it affect adipose phenotype change toward browning has not been previously reported...
May 16, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29785025/an-immune-beige-adipocyte-communication-via-nicotinic-acetylcholine-receptor-signaling
#3
Heejin Jun, Hui Yu, Jianke Gong, Juan Jiang, Xiaona Qiao, Eric Perkey, Dong-Il Kim, Margo P Emont, Alexander G Zestos, Jung-Sun Cho, Jianfeng Liu, Robert T Kennedy, Ivan Maillard, X Z Shawn Xu, Jun Wu
Beige adipocytes have recently been shown to regulate energy dissipation when activated and help organisms defend against hypothermia and obesity. Prior reports indicate that beige-like adipocytes exist in adult humans and that they may present novel opportunities to curb the global epidemic in obesity and metabolic illnesses. In an effort to identify unique features of activated beige adipocytes, we found that expression of the cholinergic receptor nicotinic alpha 2 subunit (Chrna2) was induced in subcutaneous fat during the activation of these cells and that acetylcholine-producing immune cells within this tissue regulated this signaling pathway via paracrine mechanisms...
May 21, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29781558/characteristics-of-high-and-low-risk-individuals-in-the-priority-study-urinary-proteomics-and-mineralocorticoid-receptor-antagonism-for-prevention-of-diabetic-nephropathy-in-type-2-diabetes
#4
N Tofte, M Lindhardt, K Adamova, J Beige, J W J Beulens, A L Birkenfeld, G Currie, C Delles, I Dimos, L Francová, M Frimodt-Møller, P Girman, R Göke, T Havrdova, A Kooy, H Mischak, G Navis, G Nijpels, M Noutsou, A Ortiz, A Parvanova, F Persson, P L Ruggenenti, F Rutters, I Rychlík, G Spasovski, M Speeckaert, M Trillini, H von der Leyen, P Rossing
AIM: To compare clinical baseline data in individuals with Type 2 diabetes and normoalbuminuria, who are at high or low risk of diabetic kidney disease based on the urinary proteomics classifier CKD273. METHODS: We conducted a prospective, randomized, double-blind, placebo-controlled international multicentre clinical trial and observational study in participants with Type 2 diabetes and normoalbuminuria, stratified into high- or low-risk groups based on CKD273 score...
May 21, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29777306/respiratory-manifestations-in-lps-responsive-beige-like-anchor-lrba-protein-deficient-patients
#5
Oded Shamriz, Bella Shadur, Adeeb NaserEddin, Irina Zaidman, Natalia Simanovsky, Orly Elpeleg, Eitan Kerem, Joel Reiter, Polina Stepensky
Lipopolysaccharide (LPS)-responsive beige-like anchor (LRBA) protein deficiency is a rare syndrome of primary immune deficiency and immune dysregulation. In this study, we sought to summarize our experience with respiratory manifestations in LRBA-deficient patients. We conducted a retrospective analysis of the medical records of LRBA-deficient patients treated at Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Data retrieved included pulmonary workup, disease course, treatment, and outcome. Ten patients were included...
May 18, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29775611/reduced-adiposity-by-compensatory-wat-browning-upon-ibat-removal-in-mice
#6
Zhengyu Piao, Baiqiang Zhai, Xiaoxiao Jiang, Meng Dong, Changguo Yan, Jun Lin, Wanzhu Jin
The strong effects of classic brown adipose tissue (BAT) and recruited beige adipocytes in treatment of obesity and metabolic syndrome have been attracting increasing research interest. Cold treatment is an effective, convenient approach to stimulate BAT activity and induce white adipose tissue (WAT) browning. Here, we utilized prolonged cold exposure (from 2 h to 2 weeks in a 4° cold chamber) to elucidate dynamic changes in BAT and in WAT browning during acute and chronic cold exposure in mice. BAT mass decreased quickly, with reduced lipid droplet sizes within 8 h of cold exposure owing to the utilization of BAT pre-storage triglycerides, and subsequently increased during prolonged cold exposure...
May 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29764980/interplay-of-cell-cell-contacts-and-rhoa-mrtf-a-signaling-regulates-cardiomyocyte-identity
#7
Tatjana Dorn, Jessica Kornherr, Elvira I Parrotta, Dorota Zawada, Harold Ayetey, Gianluca Santamaria, Laura Iop, Elisa Mastantuono, Daniel Sinnecker, Alexander Goedel, Ralf J Dirschinger, Ilaria My, Svenja Laue, Tarik Bozoglu, Christian Baarlink, Tilman Ziegler, Elisabeth Graf, Rabea Hinkel, Giovanni Cuda, Stefan Kääb, Andrew A Grace, Robert Grosse, Christian Kupatt, Thomas Meitinger, Austin G Smith, Karl-Ludwig Laugwitz, Alessandra Moretti
Cell-cell and cell-matrix interactions guide organ development and homeostasis by controlling lineage specification and maintenance, but the underlying molecular principles are largely unknown. Here, we show that in human developing cardiomyocytes cell-cell contacts at the intercalated disk connect to remodeling of the actin cytoskeleton by regulating the RhoA-ROCK signaling to maintain an active MRTF/SRF transcriptional program essential for cardiomyocyte identity. Genetic perturbation of this mechanosensory pathway activates an ectopic fat gene program during cardiomyocyte differentiation, which ultimately primes the cells to switch to the brown/beige adipocyte lineage in response to adipogenesis-inducing signals...
May 15, 2018: EMBO Journal
https://www.readbyqxmd.com/read/29758288/micrornas-in-brown-and-beige-fat
#8
REVIEW
Deborah Goody, Alexander Pfeifer
Brown adipose tissue (BAT) dissipates energy as heat and its activity correlates with leanness in human adults. Understanding the mechanisms behind the activation of BAT and the process of "browning", i.e. the appearance of inducible brown adipocytes called beige or brite (brown-in-white) cells in white adipose tissue (WAT), is of great interest for developing novel therapies to combat obesity. MicroRNAs (miRNAs) are small transcriptional regulators that control gene expression in a variety of tissues, including WAT and BAT...
May 11, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29757434/hdac3-selective-inhibition-activates-brown-and-beige-fat-through-prdm16
#9
Jiling Liao, Juan Jiang, Heejin Jun, Xiaona Qiao, Margo P Emont, Dong-Il Kim, Jun Wu
It has been reported that class I histone deacetylase (HDAC) inhibition increases thermogenesis in fat, but adipocyte specific Hdac3 deletions have presented inconsistent results. In this study, we observed that HDAC3 protein levels were lower in brown fat compared to that of inguinal subcutaneous adipose tissue, and were decreased in both fat depots upon cold exposure. PRDM16 physically interacted with HDAC3, and treatment with HDAC3-selective inhibitor RGFP966 induced thermogenic gene expression in murine and human fat cultures...
May 10, 2018: Endocrinology
https://www.readbyqxmd.com/read/29757365/multifaceted-roles-of-beige-fat-in-energy-homeostasis-beyond-ucp1
#10
Carlos Henrique Sponton, Shingo Kajimura
Beige adipocytes are an inducible form of thermogenic adipose cells that emerge within the white adipose tissue in response to a variety of environmental stimuli, such as chronic cold acclimation. Similar to brown adipocytes that reside in brown adipose tissue (BAT) depots, beige adipocytes are also thermogenic; however beige adipocytes possess unique, distinguishing characteristics in their developmental regulation and biological function. This review highlights recent advances in our understanding of beige adipocytes, focusing on the diverse roles of beige fat in the regulation of energy homeostasis that are independent of the canonical thermogenic pathway via uncoupling protein 1 (UCP1)...
May 10, 2018: Endocrinology
https://www.readbyqxmd.com/read/29750960/a-novel-role-for-ptk2b-in-cultured-beige-adipocyte-differentiation
#11
Bin Ni, Jared S Farrar, Shanshan Chen, Joseph C Lownik, Francesco S Celi
Adipocyte differentiation is a tightly regulated process which requires the sequential and organized expression of numerous genes and proteins. Phosphorylation of cytoplasmic proteins and key transcription factors represents a critical regulatory mechanism of the process leading to adipocyte maturation and modulation of associated metabolic pathways. Despite the recognition of the importance of protein phosphorylation in adipocyte biology, relatively little is known about the role of specific kinases in thermogenic (brown or beige) adipocyte differentiation and function...
May 8, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29750781/metabolic-benefits-of-inhibition-of-p38%C3%AE-in-white-adipose-tissue-in-obesity
#12
Shengjie Zhang, Hongchao Cao, Yan Li, Yanyan Jing, Shengnan Liu, Cheng Ye, Hui Wang, Shuxian Yu, Chengyuan Peng, Lijian Hui, Yu-Cheng Wang, Haibing Zhang, Feifan Guo, Qiwei Zhai, Hui Wang, Ruimin Huang, Ling Zhang, Jingjing Jiang, Wei Liu, Hao Ying
p38 has long been known as a central mediator of protein kinase A (PKA) signaling in brown adipocytes, which positively regulate the transcription of uncoupling protein 1 (UCP-1). However, the physiological role of p38 in adipose tissues, especially the white adipose tissue (WAT), is largely unknown. Here, we show that mice lacking p38α in adipose tissues display a lean phenotype, improved metabolism, and resistance to diet-induced obesity. Surprisingly, ablation of p38α causes minimal effects on brown adipose tissue (BAT) in adult mice, as evident from undetectable changes in UCP-1 expression, mitochondrial function, body temperature (BT), and energy expenditure...
May 11, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29740429/rapid-flow-cytometry-based-test-for-the-diagnosis-of-lipopolysaccharide-responsive-beige-like-anchor-lrba-deficiency
#13
Laura Gámez-Díaz, Elena C Sigmund, Veronika Reiser, Werner Vach, Sophie Jung, Bodo Grimbacher
The diagnosis of lipopolysaccharide-responsive beige-like-anchor-protein (LRBA) deficiency currently relies on gene sequencing approaches that do not support a timely diagnosis and clinical management. We developed a rapid and sensitive test for clinical implementation based on the detection of LRBA protein by flow cytometry in peripheral blood cells after stimulation. LRBA protein was assessed in a prospective cohort of 54 healthy donors and 57 patients suspected of LRBA deficiency. Receiver operating characteristics analysis suggested an LRBA:MFI ratio cutoff point of 2...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29730295/ifi27-is-indispensable-for-mitochondrial-function-and-browning-in-adipocytes
#14
Weiwei Jin, Wenfang Jin, Dongning Pan
Brown adipose tissue (BAT) is specialized for energy expenditure, but the signaling pathways that regulate BAT metabolism and activity are incompletely understood. Interferon (IFN) signaling is a sophisticated defense mechanism to counteract viral infection. IFNs and interferon-stimulated genes (ISGs) are reported to exert profound effects on adipocytes. IFN-α inducible protein 27 (Ifi27/ISG12a) is a BAT-enriched gene, yet no any studies on its roles in BAT have been reported. Here, we show that Ifi27 protein localizes to mitochondria and the expression of Ifi27 can be induced by β3-adrenergic activation in adipose tissues...
May 3, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29729716/diffuse-type-gastric-mucinous-and-signet-ring-cell-adenocarcinoma-in-a-captive-california-king-snake-lampropeltis-getula-californiae
#15
C-S Hsueh, W-T Li, C-R Jeng, V F Pang, H-W Chang
An adult female California king snake (Lampropeltis getula californiae) housed in Taipei Zoo was presented with a 2-week history of anorexia, fatigue and abdominal swelling. Exploratory laparotomy revealed a gastric mass with two circular perforations and multiple mottled white to beige protuberances along the mucosal surface. Histologically, the gastric mass showed an invasive, transmural growth of epithelial cells arranged in nests, lobules, acini and sheets in the mucosa and submucosa that progressively transformed into signet ring cells in the muscularis externa and subserosa...
April 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/29723433/standardized-extract-of-wild-apple-fruit-in-alkyl-polyglucoside-based-cosmetic-cream-estimation-of-stability-safety-antioxidant-activity-and-efficiency
#16
Dragana Stojiljković, Vanja Tadić, Milica Stanković, Sonja Roganović, Ivana Arsić
OBJECTIVE: The aim of this study was in vitro and in vivo characterization of cosmetic cream with 6% of wild apple fruit water extract, containing 3.5% of alpha-hydroxyacids-AHAs and polyphenolic compounds, stabilized by biodegradable alkyl-polyglucoside emulsifiers. METHODS: In vitro characterization of cream included organoleptic and physico-chemical (pH values and electrical conductivity) analysis, antioxidant activity-AA estimation (using DPPH test) during 180 days of storage at 22±2°C and determination of cosmetic active substances content-AHAs (using HPLC analysis)...
May 3, 2018: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29721515/combination-of-computer-extracted-shape-and-texture-features-enables-discrimination-of-granulomas-from-adenocarcinoma-on-chest-computed-tomography
#17
Mahdi Orooji, Mehdi Alilou, Sagar Rakshit, Niha Beig, Mohammad Hadi Khorrami, Prabhakar Rajiah, Rajat Thawani, Jennifer Ginsberg, Christopher Donatelli, Michael Yang, Frank Jacono, Robert Gilkeson, Vamsidhar Velcheti, Philip Linden, Anant Madabhushi
Differentiation between benign and malignant nodules is a problem encountered by radiologists when visualizing computed tomography (CT) scans. Adenocarcinomas and granulomas have a characteristic spiculated appearance and may be fluorodeoxyglucose avid, making them difficult to distinguish for human readers. In this retrospective study, we aimed to evaluate whether a combination of radiomic texture and shape features from noncontrast CT scans can enable discrimination between granulomas and adenocarcinomas...
April 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29719233/toward-an-understanding-of-how-immune-cells-control-brown-and-beige-adipobiology
#18
REVIEW
Francesc Villarroya, Rubén Cereijo, Joan Villarroya, Aleix Gavaldà-Navarro, Marta Giralt
Immune cells were recently found to have an unexpected involvement in controlling the thermogenic activity of brown and beige adipose tissue. Here, we review how macrophages, eosinophils, type 2 innate lymphoid cells, and T lymphocytes are linked to this process. In particular, the recruitment of alternatively activated macrophages and eosinophils is associated with brown fat activation and white fat browning. Conversely, pro-inflammatory immune cell recruitment represses the thermogenic activity of brown and beige adipose tissues via cytokines that inhibit noradrenergic signaling...
May 1, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29719227/a-strategy-for-discovery-of-endocrine-interactions-with-application-to-whole-body-metabolism
#19
Marcus M Seldin, Simon Koplev, Prashant Rajbhandari, Laurent Vergnes, Gregory M Rosenberg, Yonghong Meng, Calvin Pan, Thuy M N Phuong, Raffi Gharakhanian, Nam Che, Selina Mäkinen, Diana M Shih, Mete Civelek, Brian W Parks, Eric D Kim, Frode Norheim, Karthickeyan Chella Krishnan, Yehudit Hasin-Brumshtein, Margarete Mehrabian, Markku Laakso, Christian A Drevon, Heikki A Koistinen, Peter Tontonoz, Karen Reue, Rita M Cantor, Johan L M Björkegren, Aldons J Lusis
Inter-tissue communication via secreted proteins has been established as a vital mechanism for proper physiologic homeostasis. Here, we report a bioinformatics framework using a mouse reference population, the Hybrid Mouse Diversity Panel (HMDP), which integrates global multi-tissue expression data and publicly available resources to identify and functionally annotate novel circuits of tissue-tissue communication. We validate this method by showing that we can identify known as well as novel endocrine factors responsible for communication between tissues...
May 1, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29716708/the-effect-of-percutaneous-coronary-revascularization-on-plasma-n-terminal-pro-b-type-natriuretic-peptide-levels-in-stable-coronary-artery-disease
#20
Amit Gupta, Jahangir Rashid Beig, Nisar A Tramboo, Dil Afroze, Imran Hafeez, Hilal A Rather
BACKGROUND: This study was conducted to assess the effect of percutaneous coronary revascularization (PCR) on plasma NT-proBNP concentration in patients with chronic stable angina (CSA). METHODS: This prospective open label interventional study included 22 patients with moderate to severe CSA, normal left ventricular (LV) systolic functions and critical (>90%) proximal stenosis in one of the three major epicardial coronary arteries. After stabilization of medications for 8 weeks, resting supine plasma NT-proBNP levels were measured and patients underwent PCR of the involved vessels...
March 2018: Indian Heart Journal
keyword
keyword
106177
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"