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peripheral artery disease in elderly

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https://www.readbyqxmd.com/read/29783062/ykl-40-levels-increase-with-declining-ankle-brachial-index-and-are-associated-with-long-term-cardiovascular-mortality-in-peripheral-arterial-disease-patients
#1
Clemens Höbaus, Maximilian Tscharre, Carsten Thilo Herz, Gerfried Pesau, Thomas Wrba, Renate Koppensteiner, Gerit-Holger Schernthaner
BACKGROUND AND AIMS: YKL-40 is an inflammatory marker secreted by macrophages and is expressed in atherosclerotic plaques. YKL-40 increases in coronary artery disease (CAD) with poor coronary collateral vessel development. Higher levels are linked to reduced survival in CAD patients. Studies evaluating YKL-40 in patients with peripheral arterial disease (PAD) are scarce. This study aims to elucidate a possible link between YKL-40 and PAD severity as well as cardiovascular long-term mortality...
May 9, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29739318/safety-of-cilostazol-in-peripheral-artery-disease-a-cohort-from-a-primary-healthcare-electronic-database
#2
Jordi Real, M Catalina Serna, Maria Giner-Soriano, Rosa Forés, Guillem Pera, Esther Ribes, Maite Alzamora, Josep Ramon Marsal, Antonio Heras, Rosa Morros
BACKGROUND: Cilostazol has been associated with spontaneous reports of cardiovascular adverse events and serious bleeding. The objective of this study is to determine the relative risk of cardiovascular adverse events or haemorrhages in patients with peripheral artery disease treated with cilostazol in comparison to pentoxifylline users. METHODS: Population-based cohort study including all individuals older than 40 who initiated cilostazol or pentoxifylline during 2009-2011 in SIDIAP database...
May 8, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29728915/results-meta-analysis-and-a-first-evaluation-of-u-nox-r-the-urinary-nitrate-to-nitrite-molar-ratio-as-a-measure-of-nitrite-reabsorption-in-experimental-and-clinical-settings
#3
Dimitrios Tsikas, Erik Hanff, Alexander Bollenbach, Ruan Kruger, Vu Vi Pham, Kristine Chobanyan-Jürgens, Dirk Wedekind, Tanja Arndt, Anne Jörns, Jimmy F P Berbée, Hans M G Princen, Thomas Lücke, François Mariotti, Jean-François Huneau, Stefan Ückert, Jürgen C Frölich, Sigurd Lenzen
We recently found that renal carbonic anhydrase (CA) is involved in the reabsorption of inorganic nitrite (NO2 - ), an abundant reservoir of nitric oxide (NO) in tissues and cells. Impaired NO synthesis in the endothelium and decreased NO bioavailability in the circulation are considered major contributors to the development and progression of renal and cardiovascular diseases in different conditions including diabetes. Isolated human and bovine erythrocytic CAII and CAIV can convert nitrite to nitrous acid (HONO) and its anhydride N2 O3 which, in the presence of thiols (RSH), are further converted to S-nitrosothiols (RSNO) and NO...
May 4, 2018: Amino Acids
https://www.readbyqxmd.com/read/29716715/utility-of-ankle-brachial-index-in-screening-for-peripheral-arterial-disease-in-rural-india-a-cross-sectional-study-and-review-of-literature
#4
Ramyashree Tummala, Kinjal Banerjee, Kapil Mahajan, Keyvan Ravakhah, Anjan Gupta
BACKGROUND: Peripheral arterial disease (PAD) is an underdiagnosed illness often affecting the elderly population. Ankle brachial index (ABI) is a good diagnostic tool for PAD in outpatient practice, but remains underused. MATERIALS AND METHODS: Patients were recruited from an outpatient medical camp in rural India, and assessed for symptoms and pre-existing risk factors. Measured ABI≤0.9 was considered abnormal and considered PAD. RESULTS: Out of 100 patients recruited, PAD was diagnosed in 57 patients...
March 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29629537/different-associations-of-plasma-biomarkers-in-alzheimer-s-disease-mild-cognitive-impairment-vascular-dementia-and-ischemic-stroke
#5
Jingwei Shang, Toru Yamashita, Yusuke Fukui, Dongjing Song, Xianghong Li, Yun Zhai, Yumiko Nakano, Ryuta Morihara, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe
BACKGROUND AND PURPOSE: Cognitive and cerebrovascular diseases are common in the elderly, but differences in the plasma levels and associations of plasma biomarkers in these diseases remain elusive. METHODS: The present study investigated differences in plasma fatty acids [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)], adiponectin, reptin, plasma markers of inflammation [high-sensitivity C-reactive protein (hsCRP) and serum amyloid A (serum AA)], and plasma lipids [high-density lipoprotein and low-density lipoprotein (LDL)] in patients with Alzheimer's disease (AD) (n=266), mild cognitive impairment (MCI) (n=44), vascular dementia (VaD) (n=33), and ischemic stroke (IS) (n=200) in comparison to normal controls (n=130)...
January 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29628610/gender-differences-in-peripheral-vascular-disease
#6
REVIEW
Kristofer Schramm, Paul J Rochon
In the past 20 years, peripheral artery disease (PAD) has been increasingly recognized as a significant cause of morbidity and mortality in the United States. PAD has traditionally been identified as a male-dominant disease; however, recent population trends and studies in PAD suggest that women are affected at least as often as men. Women comprise a larger population of the elderly than men, as well as an increasing proportion of patients with PAD. Much of the existing research on PAD has focused on whole populations, and gender-specific data on PAD is sparse...
March 2018: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/29576781/the-new-mayo-clinic-risk-score-characteristics-in-acute-coronary-syndrome-in-patients-following-percutaneous-coronary-intervention
#7
Lukman Zulkifli Amin, Hilman Zulkifli Amin, Sally Aman Nasution, Marulam Panggabean, Hamzah Shatri
Background: Mortality and major adverse cardiac events (MACE) frequently occur after percutaneous coronary intervention (PCI). Therefore, the ability to predict such events through an established risk stratification method is of great importance. The present study was aimed at determining the risk stratification of mortality and MACE in post-PCI patients at the intensive cardiac care unit of Cipto Mangunkusumo Hospital (CMH) using 7 variables of the New Mayo Clinic Risk Score (NMCRS). Method: This cross-sectional study drew upon secondary data gathered from the medical records of 313 patients that underwent PCI at the intensive cardiac care unit (ICCU) of CMH between August 1st, 2013, and August 31st, 2014...
October 2017: Journal of Tehran Heart Center
https://www.readbyqxmd.com/read/29535455/comparison-of-pulse-wave-velocity-and-pulse-pressure-amplification-in-association-with-target-organ-damage-in-community-dwelling-elderly-the-northern-shanghai-study
#8
Bin Bai, Jiadela Teliewubai, Yuyan Lu, Shikai Yu, Jing Xiong, Chen Chi, Yiwu Zhou, Hongwei Ji, Ximin Fan, Jacques Blacher, Jue Li, Yi Zhang, Yawei Xu
This study aimed to investigate the discrepancy between pulse wave velocity (PWV) and pulse pressure amplification (PPA) in association with hypertensive target organ damage (TOD) in the elderly. From June 2014 to August 2015, 1599 participants aged >65 years old from communities located in northern Shanghai were recruited. Carotid-femoral pulse wave velocity (cfPWV), peripheral blood pressure (BP), central BP and other TOD indicators, including the ratio of the early ventricular filling velocity (E) to the peak velocity of the tissue Doppler velocity of septal mitral annulus (E/Ea), left ventricular mass index (LVMI), carotid intima-medium thickness (CIMT), estimated glomerular filtration rate (eGFR), and urinary albumin-creatinine ratio (ACR), were determined for each participant...
May 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29519384/public-health-impact-of-the-centers-for-medicare-and-medicaid-services-decision-on-pass-through-add-on-payments-for-drug-coated-balloons-a-call-to-action
#9
REVIEW
Mehdi H Shishehbor, Michael R Jaff, Joshua A Beckman, Sanjay Misra, Peter A Schneider, Robert Lookstein, Vikram S Kashyap, Herbert D Aronow, W Schuyler Jones, Christopher J White
On Wednesday, November 1, 2017, the Centers for Medicare and Medicaid Services (CMS) made a public decision to end the transitional pass-through add-on payment for drug-coated balloons beginning January 1, 2018, without creating a new ambulatory payment classification rate for these devices. In this Viewpoint, the authors highlight the disconnect between the CMS's decision not to create a new ambulatory payment classification category for drug-coated balloons despite demonstrated clinical superiority. The authors believe this decision is more in line with a rigid fee-for-service payment system than a value-based system that encourages quality over quantity, and disadvantages both the elderly and the poor...
March 12, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29478020/chinese-observational-prospective-study-of-ageing-population-with-chronic-kidney-disease-c-option-a-study-protocol
#10
Shuang Liang, Wen-Ling Wang, Fang-Lei Zhu, Shu-Wei Duan, Xue-Feng Sun, Xiang-Mei Chen, Guang-Yan Cai
INTRODUCTION: The proportion of elderly people is steadily rising worldwide, especially in low-income and middle-income countries, including China. Chronic kidney disease (CKD) is a common disorder in older people. However, little is known about the epidemiology of CKD and its consequences among the elderly. Improvements on clinical guidelines and healthcare policies for this population are required. This study aims to examine the risk factors for progression of CKD among the elderly and develop models to identify subgroups who are at high risk...
February 24, 2018: BMJ Open
https://www.readbyqxmd.com/read/29463192/home-based-exercise-for-elderly-patients-with-intermittent-claudication-limited-by-osteoarticular-disorders-feasibility-and-effectiveness-of-a-low-intensity-programme
#11
Nicola Lamberti, Sofia Straudi, Efisio Lissia, Lorenza Cavazzini, Sergio Buja, Roberto Manfredini, Nino Basaglia, Fabio Manfredini
BACKGROUND: Peripheral arterial disease (PAD) is a common cardiovascular pathology affecting mobility in elderly. Osteoarticular diseases (ODs), responsible for functional limitations and confounding leg symptoms, may interfere with exercise therapy. This study evaluates the feasibility and effectiveness of a structured home-based exercise programme on rehabilitative outcomes in a cohort of elderly PAD patients with and without coexisting ODs. PATIENTS AND METHODS: Patients were enrolled from 2002 to 2016 in an exercise programme prescribed and controlled at the hospital and based on two daily 10-minute home walking sessions below the self-selected speed...
April 2018: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/29446219/hypertension-in-a-resource-limited-setting-is-it-associated-with-end-organ-damage-in-older-adults-in-rural-tanzania
#12
Harry W I Putnam, Rebecca Jones, Jane Rogathi, William K Gray, Bernadetha Swai, Matthew Dewhurst, Felicity Dewhurst, Richard W Walker
Few data from sub-Saharan Africa exist on the effects of hypertension on the organs of the human body. We aimed to establish the prevalence of hypertensive end organ damage (EOD) in an elderly cohort of Tanzanians. The population aged 70 years and over of 2 villages in northern Tanzania (n = 246), had blood pressure (BP) data available from 2010 and 2013, and underwent in-depth follow-up for markers of hypertensive EOD in 2016. Assessment included ankle-brachial pressure index, lying-standing BP, electrocardiogram, and mid-stream urine dip...
February 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29440471/clinical-and-demographic-characteristics-associated-with-suboptimal-primary-stroke-and-transient-ischemic-attack-prevention-retrospective-analysis
#13
MULTICENTER STUDY
Grace M Turner, Melanie Calvert, Max G Feltham, Ronan Ryan, Samuel Finnikin, Tom Marshall
BACKGROUND AND PURPOSE: Primary prevention of stroke and transient ischemic attack (TIA) is important to reduce the burden of these conditions; however, prescribing of prevention drugs is suboptimal. We aimed to identify individual clinical and demographic characteristics associated with potential missed opportunities for prevention therapy with lipid-lowering, anticoagulant, or antihypertensive drugs before stroke/TIA. METHODS: We analyzed anonymized electronic primary care records from a UK primary care database that covers 561 family practices...
March 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29402196/peripheral-artery-disease-is-associated-with-frailty-in-chronic-hemodialysis-patients
#14
Michihiro Okuyama, Hidemi Takeuchi, Haruhito A Uchida, Yuki Kakio, Yuka Okuyama, Ryoko Umebayashi, Kentaro Wada, Hitoshi Sugiyama, Ken Sugimoto, Hiromi Rakugi, Shingo Kasahara, Jun Wada
Objectives The clinical condition of frailty is a common problem in the elderly population. However, the relationship between peripheral artery disease and frailty in hemodialysis patients remains unknown. The aim of this study was to identify the relationships between peripheral artery disease and frailty in Japanese chronic hemodialysis patients. Methods A total of 362 chronic hemodialysis patients who regularly visited six institutions were enrolled. To evaluate frailty, the modified Fried's frailty phenotype adjusted for Japanese were used...
January 1, 2018: Vascular
https://www.readbyqxmd.com/read/29387461/hypertension-and-frailty-syndrome-in-old-age-current-perspectives
#15
Izabella Uchmanowicz, Anna Chudiak, Beata Jankowska-Polańska, Robbert Gobbens
Hypertension is both a health problem and a financial one globally. It affects nearly 30 % of the general population. Elderly people, aged ≥65 years, are a special group of hypertensive patients. In this group, the overall prevalence of the disease reaches 60 %, rising to 70 % in those aged ≥80 years. In the elderly population, isolated systolic hypertension is quite common. High systolic blood pressure is associated with an increased risk of cardiovascular disease, cerebrovascular disease, peripheral artery disease, cognitive impairment and kidney disease...
November 2017: Cardiac failure review
https://www.readbyqxmd.com/read/29375897/the-importance-of-community-screening-of-asymptomatic-elderly-for-peripheral-arterial-disease-by-doppler-ultrasound-and-ankle-brachial-index
#16
Ayşe Keven, Mehmet Sedat Durmaz
Background: Peripheral arterial disease is an atherosclerotic disease characterized by an increase in morbidity and mortality. For these reasons early diagnosis of peripheral arterial disease is important. Ankle-brachial systolic pressure index measurement is frequently used in screening studies. Evaluating waveforms of distal lower extremities with Doppler ultrasound can be used as a screening program and provides more accurate information on peripheral arterial disease. Aim: We investigate the prevalence of peripheral arterial disease, compare the efficacy of Doppler ultrasound evaluation of distal lower extremity waveforms and ankle-brachial systolic pressure index measurement in screening programs, and discuss the importance of early diagnosis of asymptomatic cases...
December 2017: Journal of Ultrasonography
https://www.readbyqxmd.com/read/29346331/growth-hormone-gh-and-cardiovascular-system
#17
REVIEW
Diego Caicedo, Oscar Díaz, Pablo Devesa, Jesús Devesa
This review describes the positive effects of growth hormone (GH) on the cardiovascular system. We analyze why the vascular endothelium is a real internal secretion gland, whose inflammation is the first step for developing atherosclerosis, as well as the mechanisms by which GH acts on vessels improving oxidative stress imbalance and endothelial dysfunction. We also report how GH acts on coronary arterial disease and heart failure, and on peripheral arterial disease, inducing a neovascularization process that finally increases flow in ischemic tissues...
January 18, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29225591/incidence-of-peripheral-arterial-disease-and-its-association-with-pulse-pressure-a-prospective-cohort-study
#18
Yong Mao, Yixiang Huang, Haining Yu, Peng Xu, Guangping Yu, Jinming Yu, Yiqiang Zhan
Background: The association of pulse pressure and peripheral arterial disease (PAD) has seldom been examined using a prospective design. This study aimed to investigate the association of pulse pressure with PAD incidence in an elderly general population. Methods: We utilized data from a cohort conducted in Beijing with additionally 2-year follow-up time. PAD was defined as an ankle brachial index value <0.9 in either leg. Cox proportional hazard regression model was used to quantify the magnitude of pulse pressure on PAD incidence...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29204653/national-patterns-of-carotid-revascularization-before-and-after-the-carotid-revascularization-endarterectomy-vs-stenting-trial-crest
#19
Fadar Oliver Otite, Priyank Khandelwal, Amer M Malik, Seemant Chaturvedi
Importance: The Carotid Revascularization Endarterectomy vs Stenting Trial (CREST) showed greater safety of carotid artery stenting (CAS) in patients younger than 70 years and carotid endarterectomy (CEA) in those older than 70 years. It is unknown how the result of CREST has influenced carotid revascularization choices in the United States. Objective: To evaluate national patterns in CAS performance in patients older than 70 years in the post-CREST (2011-2014) compared with the pre-CREST (2007-2010) era...
January 1, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29144514/catheter-ablation-of-atrial-fibrillation-in-elderly-population
#20
Josef Kautzner, Petr Peichl, Marek Sramko, Robert Cihak, Bashar Aldhoon, Dan Wichterle
Background: Although elderly patients have been included in published series of catheter ablation for atrial fibrillation (AF), clinical benefit and safety remain still less defined in this population. A retrospective analysis of the results of catheter ablation for AF in a large volume center focused on comparison of elderly patients with the rest of the patient cohort was conducted in this study. Methods: Consecutive patients who underwent catheter ablation for AF between January 2001 and December 2016 were analysed...
September 2017: Journal of Geriatric Cardiology: JGC
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