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Rhinovirus syk pathway

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https://www.readbyqxmd.com/read/21171946/hrv-signaling-in-airway-epithelial-cells-is-regulated-by-itam-mediated-recruitment-and-activation-of-syk
#1
Christine Lau, Patricia Castellanos, Dimitre Ranev, Xiaomin Wang, Chung-Wai Chow
Human rhinovirus (HRV), cause of the common cold, is a leading cause of exacerbations of asthma and chronic obstruction pulmonary disease (COPD). Binding of HRV to ICAM (intercellular adhesion molecule)-1, its major receptor, induces a profound inflammatory response from airway epithelial cells. My laboratory has identified Syk tyrosine kinase to be an early regulator of HRV-ICAM-1 signalling: Syk mediates replication-independent p38 mitogen-activated protein (MAP) kinase and phosphatidyl-inositol 3 (PI3)-kinase activation, interleukin (IL)-8 expression, as well as HRV internalization via clathrin-mediated endocytosis...
May 2011: Protein and Peptide Letters
https://www.readbyqxmd.com/read/18178826/syk-associates-with-clathrin-and-mediates-phosphatidylinositol-3-kinase-activation-during-human-rhinovirus-internalization
#2
Christine Lau, Xiaomin Wang, Lihua Song, Michelle North, Shahina Wiehler, David Proud, Chung-Wai Chow
Human rhinovirus (HRV) causes the common cold. The most common acute infection in humans, HRV is a leading cause of exacerbations of asthma and chronic obstruction pulmonary disease because of its ability to exacerbate airway inflammation by altering epithelial cell biology upon binding to its receptor, ICAM-1. ICAM-1 regulates not only viral entry and replication but also signaling pathways that lead to inflammatory mediator production. We recently demonstrated the Syk tyrosine kinase to be an important mediator of HRV-ICAM-1 signaling: Syk regulates replication-independent p38 MAPK activation and IL-8 expression...
January 15, 2008: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/17082600/syk-is-downstream-of-intercellular-adhesion-molecule-1-and-mediates-human-rhinovirus-activation-of-p38-mapk-in-airway-epithelial-cells
#3
Xiaomin Wang, Christine Lau, Shahina Wiehler, André Pow, Tony Mazzulli, Carlos Gutierrez, David Proud, Chung-Wai Chow
The airway epithelium is the primary target of inhaled pathogens such as human rhinovirus (HRV). Airway epithelial cells express ICAM-1, the major receptor for HRV. HRV binding to ICAM-1 mediates not only viral entry and replication but also a signaling cascade that leads to enhanced inflammatory mediator production. The specific signaling molecules and pathways activated by HRV-ICAM-1 interactions are not well characterized, although studies in human airway epithelia implicate a role for the p38 MAPK in HRV-induced cytokine production...
November 15, 2006: Journal of Immunology: Official Journal of the American Association of Immunologists
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