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cause of abortion in first trimester

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https://www.readbyqxmd.com/read/28627774/decreased-expression-of-wnt2-in-villi-of-unexplained-recurrent-spontaneous-abortion-patients-may-cause-trophoblast-cell-dysfunction-via-downregulated-wnt-%C3%AE-catenin-signaling-pathway
#1
Ning Li, Shuhong Li, Yanwei Wang, Jiahui Wang, Kai Wang, Xin Liu, Yan Li, Juan Liu
WNT2 has been reported to be important for placental development, especially for the proper vascularization of the placenta. However, its precise role in first-trimester trophoblast cells is still unknown. WNT2 expression in the villous tissues of unexplained recurrent spontaneous abortion (URSA) patients was compared with that of healthy women by Western blot. The function of WNT2 in HTR-8/SVneo trophoblast cells was evaluated by altering the cellular WNT2 level through overexpression and shRNA knockdown. The molecular mechanism of the effect of WNT2 on trophoblast cells was investigated...
June 19, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28412850/assessment-of-hysteroscopic-role-in-management-of-women-with-recurrent-pregnancy-loss
#2
M Elsokkary, M Elshourbagy, K Labib, A Mamdouh, Y El-Shahawy, Wael S Nossair, O Abd El Fattah, H Hemeda, S Sallam, Waleed M Khalaf, M Ali
OBJECTIVES: To assess the hysteroscopic value in the management of intrauterine lesion in women with recurrent pregnancy loss. METHODS: This study was done in Ain Shams Maternity Hospital after the approval of the research Ethics Committee, during the period between August 2014 and December 2015 where 200 nonpregnant women with a history of three or more consecutive unexplained first and second trimester miscarriages before 20 weeks were recruited from recurrent miscarriage clinic...
May 2, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28402552/induced-abortion
#3
(no author information available yet)
Abortion is common. Data on abortion rates are inexact but can be used to explore trends. Globally, the estimated rate in the period 2010-2014 was 35 abortions per 1000 women (aged 15-44 years), five points less than the rate of 40 for the period 1990-1994. Abortion laws vary around the world but are generally more restrictive in developing countries. Restrictive laws do not necessarily deter women from seeking abortion but often lead to unsafe practice with significant mortality and morbidity. While a legal framework for abortion is a prerequisite for availability, many laws, which are not evidence based, restrict availability and delay access...
June 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28381214/rubella-seroprevalence-and-real-time-pcr-detection-of-rubv-among-congolese-pregnant-women
#4
Josue Zanga, Makola Kennedy Mbanzulu, Arnold-Freddy Kabasele, Nlandu Roger Ngatu, Dimosi Roger Wumba
BACKGROUND: Rubella is an acute infectious disease caused by Rubella virus (RUBV). RUBV remains an important pathogen worldwide, causing approximately 100 000 cases of congenital rubella syndrome (CRS) every year; and the most severe consequence of rubella is teratogenicity. The aim of this study was to estimate the prevalence of RUBV IgG antibodies and determine RUBV genotypes in Congolese pregnant women in Kongo central province, Democratic Republic of Congo (DRC). METHODS: This was a prospective cross-sectional study that consisted of a laboratory analysis of blood samples from 78 pregnant women to check for the presence of RUBV IgG antibodies, and also determine RUBV genotypes in seropositive samples (using primers targeting RUBV nucleoprotein), with the use of serological and molecular methods, respectively...
April 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28344965/tuberculous-peritonitis-in-the-first-trimester-of-pregnancy
#5
Sukyung Jung, Nae Ri Yun, Jeong Ok Kim, Jeong Hoon Lee, Ho Yeon Kim, Eunseop Song, Byoung Ick Lee, Sung Ook Hwang, Soo Ran Choi
Tuberculous peritonitis in pregnancy is a rare form of extrapulmonary tuberculosis that is not easily diagnosed. The clinical presentations of tuberculous peritonitis are usually non-specific and mimic those of other diseases, such as ovarian malignancy or chronic liver disease, and this non-specificity can cause diagnostic delays and complications. The authors report the case of a 31-year-old primigravida woman who presented with uncontrolled fever, dyspnea, elevated liver enzymes, and mild abdominal distension at 13+2 weeks of gestation...
March 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28340831/pregnancy-and-delivery-in-the-sequel-of-kidney-transplantation-single-center-study-of-8-years-experience
#6
Y Yuksel, S Tekin, D Yuksel, I Duman, M Sarier, L Yucetin, E Turan, H Celep, T Ugurlu, M M Inal, Y H Asuman, A Demirbas
BACKGROUND: Depending on hyphothalamic, hyphophyseal, and gonadal axis dysfunction, anovulatory irregular cycles occur and the probability of pregnancy decreases in the patients with chronic kidney disease (CKD). Maternal mortality and morbidity rates are increased in CKD patients; the risk of premature delivery is 70% and the risk of preeclampsia is 40% more than normal among those with a creatine level of >2.5 mg/dL. METHODS: If a pregnancy is expected in the sequel of kidney transplantation (KT), a multidisciplinary team approach should be adopted and both the gynecologist and the nephrologist should follow the patient simultaneously...
April 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28326648/changes-in-expression-of-the-cd200-tolerance-signaling-molecule-and-its-receptor-cd200r-by-villus-trophoblasts-during-first-trimester-missed-abortion-and-in-chronic-histiocytic-intervillositis
#7
David A Clark, Jennifer M Dmetrichuk, Elizabeth McCready, Sukhbinder Dhesy-Thind, Jorge L Arredondo
PROBLEM: Expression of CD200 at the feto-maternal interface is associated with successful murine and human pregnancy. CD200 binding to CD200 receptors on lymphomyeloid cells suppresses inflammation and induces Tregs. CD200 receptors are also expressed on mouse and human placental trophoblast cells. What is the expression of CD200 and CD200R in human missed abortions which have preserved Treg levels and in chronic histiocytic intervillositis (CHI) where maternal inflammatory cells cause IUGR? METHODS: Immunohistiochemistry for CD200, CD200R, and Ki67 using human placental sections from missed abortions, term placenta, and CHI...
March 22, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28299234/different-sonographic-faces-of-ectopic-pregnancy
#8
Charu Chanana, Nishant Gupta, Itisha Bansal, Kusum Hooda, Pranav Sharma, Mohit Gupta, Darshan Gandhi, Yogesh Kumar
Vaginal bleeding in the first trimester has wide differential diagnoses, the most common being a normal early intrauterine pregnancy, with other potential causes including spontaneous abortion and ectopic pregnancy. The incidence of ectopic pregnancy is approximately 2% of all reported pregnancies and is one of the leading causes of maternal mortality worldwide. Clinical signs and symptoms of ectopic pregnancy are often nonspecific. History of pelvic pain with bleeding and positive β-human chorionic gonadotropin should raise the possibility of ectopic pregnancy...
2017: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/28257646/a-decade-of-progress-providing-safe-abortion-services-in-ethiopia-results-of-national-assessments-in-2008-and-2014
#9
Yohannes Dibaba, Sally Dijkerman, Tamara Fetters, Ann Moore, Hailemichael Gebreselassie, Yirgu Gebrehiwot, Janie Benson
BACKGROUND: Ethiopia has one of the highest maternal mortality ratios in the world (420 per 100,000 live births in 2013), and unsafe abortion continues to be one of the major causes. To reduce deaths and disabilities from unsafe abortion, Ethiopia liberalized its abortion law in 2005 to allow safe abortion under certain conditions. This study aimed to measure how availability and utilization of safe abortion services has changed in the last decade in Ethiopia. METHODS: This paper draws on results from nationally representative health facility studies conducted in Ethiopia in 2008 and 2014...
March 4, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28217618/recurrent-first-trimester-abortion-in-a-young-female-rare-presentation-of-takayasu-arteritis
#10
Suruchi Gupta, Puneet Chhabra, Nikhil Gupta, Parul Aggarwal
Takayasu arteritis (TA) is a chronic, progressive, autoimmune, idiopathic, and large-vessel vasculitis that usually affects young adults, especially females. TA primarily affects the aorta and its major branches, the coronary arteries, and the pulmonary arteries. Recurrent pregnancy loss is usually defined as three or more consecutive losses occurring at <20 weeks' gestation of a clinically recognized pregnancy. Common causes of recurrent fetal loss include anatomic, chromosomal, hormonal, infectious, or antiphospholipid antibody syndrome...
July 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28102101/thyroid-in-pregnancy-from-physiology-to-screening
#11
Drahomira Springer, Jan Jiskra, Zdenka Limanova, Tomas Zima, Eliska Potlukova
Thyroid hormones are crucial for the growth and maturation of many target tissues, especially the brain and skeleton. During critical periods in the first trimester of pregnancy, maternal thyroxine is essential for fetal development as it supplies thyroid hormone-dependent tissues. The ontogeny of mature thyroid function involves organogenesis, and maturation of the hypothalamus, pituitary and the thyroid gland; and it is almost complete by the 12th-14th gestational week. In case of maternal hypothyroidism, substitution with levothyroxine must be started in early pregnancy...
March 2017: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/28079434/previous-pregnancy-outcomes-and-subsequent-pregnancy-anxiety-in-a-quebec-prospective-cohort
#12
Gabriel D Shapiro, Jean R Séguin, Gina Muckle, Patricia Monnier, William D Fraser
INTRODUCTION: Pregnancy anxiety is an important psychosocial risk factor that may be more strongly associated with adverse birth outcomes than other measures of stress. Better understanding of the upstream predictors and causes of pregnancy anxiety could help to identify high-risk women for adverse maternal and infant outcomes. The objective of the present study was to measure the associations between five past pregnancy outcomes (live preterm birth (PTB), live term birth, miscarriage at <20 weeks, stillbirth at ≥20 weeks, and elective abortion) and pregnancy anxiety at three trimesters in a subsequent pregnancy...
June 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28042412/molecular-detection-and-genotypic-characterization-of-toxoplasma-gondii-in-paraffin-embedded-fetoplacental-tissues-of-women-with-recurrent-spontaneous-abortion
#13
Amir Abdoli, Abdolhossein Dalimi, Haleh Soltanghoraee, Fatemeh Ghaffarifar
BACKGROUND: Congenital toxoplasmosis is an important cause of spontaneous abortion worldwide. However, there is limited information on detection and genotypic characterization of Toxoplasma gondii (T. gondii) in women with recurrent spontaneous abortion (RSA). The aim of this study is the molecular detection and genotypic characterization of T. gondii in formalin-fixed, paraffin-embedded fetoplacental tissues (FFPTs) of women with RSA that have referred to the Avicenna Research Institute in Tehran, Iran...
January 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/27968917/current-smoking-in-pregnant-women-in-five-geographical-areas-of-china-a-cross-sectional-survey
#14
Xianglong Xu, Yunshuang Rao, Sha Deng, Sheng Liu, Jeff J Guo, Manoj Sharma, Yong Zhao
BACKGROUND: Smoking during pregnancy is related to many adverse outcomes on infants. Smoking during pregnancy can cause abortion, premature birth, stillbirth, increased sudden infant death risk, and low birthweight. The aim of this study was to probe the differences in smoking among pregnant women with diverse characteristics. METHODS: In this cross-sectional study, 2345 pregnant women aged 18 years and older were surveyed in person by investigators from June 1, to Aug 31, 2015, from 16 hospitals in five provinces of Mainland China (Chongqing, Chengdu, Zunyi, Liaocheng, and Tianjin)...
October 2016: Lancet
https://www.readbyqxmd.com/read/27925163/induced-abortion-and-mental-health
#15
LETTER
Oskari Heikinheimo, Elina Pohjoranta, Elena Toffol, Satu Suhonen, Timo Partonen
No abstract text is available yet for this article.
December 7, 2016: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/27752285/molecular-cytogenetic-analysis-of-early-spontaneous-abortions-conceived-from-varying-assisted-reproductive-technology-procedures
#16
Tonghua Wu, Biao Yin, Yuanchang Zhu, Guangui Li, Lijun Ye, Chunmei Chen, Yong Zeng, Desheng Liang
BACKGROUND: Spontaneous abortion (SA) is the most common complication of pregnancy, and chromosome aberrations are the principal cause of the first trimester abortuses in natural conception (NC) The increasing use of assisted reproductive technology (ART) has raised concern about chromosome abnormalities in ART-initiated pregnancies. Up to date, the literature on the risk of aneuploidy in failed pregnancies among various ART factors remain limited and inconclusive. This study aimed to explore the genetic etiology of pregnancy loss conceived from varying ART procedures...
2016: Molecular Cytogenetics
https://www.readbyqxmd.com/read/27490204/critical-review-of-the-current-recommendations-for-the-treatment-of-systemic-inflammatory-rheumatic-diseases-during-pregnancy-and-lactation
#17
REVIEW
Roger A Levy, Guilherme R de Jesús, Nilson R de Jesús, Evandro M Klumb
The crucial issue for a better pregnancy outcome in women with autoimmune rheumatic diseases is appropriate planning, with counseling of the ideal timing and treatment adaptation. Drugs used to treat rheumatic diseases may interfere with fertility or increase the risk of miscarriages and congenital abnormalities. MTX use post-conception is clearly linked to abortions as well as major birth defects, so it should be stopped 3months before conception. Leflunomide causes abnormalities in animals even in low doses...
October 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27478773/homozygosity-for-a-robertsonian-translocation-13q-14q-in-a-phenotypically-normal-44-xx-female-with-a-history-of-recurrent-abortion-and-a-normal-pregnancy-outcome
#18
Mohammad Miryounesi, Mehdi Diantpour, Elahe Motevaseli, Soudeh Ghafouri-Fard
BACKGROUND: Robertsonian translocations are structural chromosomal abnormalities caused by fusion of two acrocentric chromosomes. In carriers of such translocations, different modes of segregations would result in the formation of either balanced (alternate segregation mode) or unbalanced (adjacent 1, adjacent 2, and 3:1 segregation modes) gametes. In addition, there is an increased risk for imprinting disorders in their offspring. Although it has been estimated that 1/1000 healthy persons carry a Robertsonian translocation, homozygosity for this type of structural chromosomal abnormality has been reported rarely...
July 2016: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/27437309/a-comparative-study-to-evaluate-the-efficacy-of-vaginal-vs-oral-prostaglandin-e1-analogue-misoprostol-in-management-of-first-trimester-missed-abortion
#19
Sheeba Marwah, Supriya Gupta, Neera Parothi Batra, Vidhu Bhasin, Veena Sarna, Nirlep Kaur
INTRODUCTION: Missed miscarriages, occurring in upto 15% of all clinically recognized pregnancies are a cause of concern for the patients. Though many researchers in the past have compared the surgical and medical approaches in management of such patients, only a few have executed an appraisal of two routes of misoprostol at equal dosages in treatment of first trimester missed miscarriages. AIM: To compare the efficacy of misoprostol by vaginal and oral route, for the management of first trimester missed abortion; and to recognize the utility of misoprostol for cervical dilation prior to any surgical termination of pregnancy...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27363040/genetic-polymorphism-of-toxoplasma-gondii-from-recently-infected-aborted-egyptian-women
#20
Mohamed S Badr, Samar S Attia, Walid S El-Sherbiny, El Ebidi Abd-Allah M A, Hesham M Hefny, Ahmed N M Salem
Toxoplasmosis caused by Toxoplasma gondii is one of the most prevalent parasitic diseases in human beings. Human toxoplasmosis can be associated with serious clinical manifestations, particularly in developing fetus. The aim of the current study was to identify the possible lineage type of Toxoplasma gondii, molecularly detected in placental samples of women whose pregnancies were spontaneously terminated in the first trimester. Preliminary detection of Toxoplasma genomic materials was done by a SYBR green qPCR technology...
April 2016: Journal of the Egyptian Society of Parasitology
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