keyword
https://read.qxmd.com/read/38493230/risk-factors-for-collisions-attributed-to-microsleep-related-behaviors-while-driving-in-professional-truck-drivers
#1
JOURNAL ARTICLE
Hiroyuki Sawatari, Hajime Kumagai, Kengo Kawaguchi, Yuka Kiyohara, Noriyuki Konishi, Aki Arita, Mitsuo Hayashi, Toshiaki Shiomi
Sleep-disordered breathing (SDB) is prevalent among professional drivers. Although SDB is a known risk factor for truck collisions attributed to microsleep-related behaviors at the wheel (TC-MRBs), the usefulness of overnight pulse oximetry for predicting TC-MRBs is debatable. This retrospective study assessed the association between overnight pulse oximetry parameters, the Epworth Sleepiness Scale (ESS), and TC-MRBs, confirmed by dashcam footage. This study included 108 matched professional truck drivers (TC-MRBs: N = 54; non-TC-MRBs: N = 54), with a mean age and body mass index of 41...
March 16, 2024: Scientific Reports
https://read.qxmd.com/read/38493225/a-novel-role-for-phospholamban-in-the-thalamic-reticular-nucleus
#2
JOURNAL ARTICLE
Benjamin Klocke, Aikaterini Britzolaki, Joseph Saurine, Hayden Ott, Kylie Krone, Kiara Bahamonde, Connor Thelen, Christos Tzimas, Despina Sanoudou, Evangelia G Kranias, Pothitos M Pitychoutis
The thalamic reticular nucleus (TRN) is a brain region that influences vital neurobehavioral processes, including executive functioning and the generation of sleep rhythms. TRN dysfunction underlies hyperactivity, attention deficits, and sleep disturbances observed across various neurodevelopmental disorders. A specialized sarco-endoplasmic reticulum calcium (Ca2+ ) ATPase 2 (SERCA2)-dependent Ca2+  signaling network operates in the dendrites of TRN neurons to regulate their bursting activity. Phospholamban (PLN) is a prominent regulator of SERCA2 with an established role in myocardial Ca2 + -cycling...
March 16, 2024: Scientific Reports
https://read.qxmd.com/read/38492265/social-class-stigma-and-poorer-health-behaviors-evidence-from-the-eating-in-america-study
#3
JOURNAL ARTICLE
David G Figueroa, Jordan E Parker, Jeffrey M Hunger, Michael W Kraus, Keely A Muscatell, A Janet Tomiyama
Although the association between objective markers of low socioeconomic status (SES) and poor health is well established, one underexamined possibility is that over and above objective SES, social class stigma-experiences and anticipation of discrimination based on social class-might undermine people's ability to engage in healthy behaviors. Participants (N = 2022) were recruited between December 2019 and January 2020 via a national Qualtrics panel that was census-matched to the U.S. population in age, gender, income, race/ethnicity, and census region...
March 12, 2024: Social Science & Medicine
https://read.qxmd.com/read/38491789/sleep-disorders-cause-parkinson-s-disease-or-the-reverse-is-true-good-gaba-good-night
#4
REVIEW
Hayder M Al-Kuraishy, Ali I Al-Gareeb, Ali K Albuhadily, Yaser Hosny Ali Elewa, Ammar Al-Farga, Faisal Aqlan, Mahmoud Hosny Zahran, Gaber El-Saber Batiha
BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative brain disease due to degeneration of dopaminergic neurons (DNs) presented with motor and non-motor symptoms. PD symptoms are developed in response to the disturbance of diverse neurotransmitters including γ-aminobutyric acid (GABA). GABA has a neuroprotective effect against PD neuropathology by protecting DNs in the substantia nigra pars compacta (SNpc). It has been shown that the degeneration of GABAergic neurons is linked with the degeneration of DNs and the progression of motor and non-motor PD symptoms...
March 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38489933/behavioral-weight-management-use-in-the-veterans-health-administration-sociodemographic-and-health-correlates
#5
JOURNAL ARTICLE
Jessica Y Breland, Ivan Raikov, Katherine J Hoggatt, Ciaran S Phibbs, Shira Maguen, Christine Timko, Fay Saechao, Susan M Frayne
INTRODUCTION: Over 40 % of United States Veterans Health Administration (VHA) primary care patients have obesity. Few patients use VHA's flagship weight management program, MOVE! and there is little information on other behavioral weight management program use. METHODS: The national United States cohort included over 1.5 million primary care patients with obesity, age 18-79, based on VHA administrative data. Gender stratified multivariable logistic regression identified correlates of weight management use in the year after a patient's first primary care appointment (alpha of 0...
March 4, 2024: Eating Behaviors
https://read.qxmd.com/read/38489578/free-water-imaging-of-the-nucleus-basalis-of-meynert-in-patients-with-idiopathic-rem-sleep-behavior-disorder-and-parkinson-disease
#6
JOURNAL ARTICLE
Dongling Zhang, Liche Zhou, Chenxi Lu, Tao Feng, Jun Liu, Tao Wu
BACKGROUND AND OBJECTIVES: Cognitive impairments are common in idiopathic REM sleep behavior disorder (iRBD), in which the cholinergic degeneration of nucleus basalis of Meynert (NBM) may play an important role. However, the progressive changes of NBM, the relationship between progressive NBM degeneration and progression of cognitive impairments, and whether degeneration of the NBM can predict cognitive decline in patients with iRBD remain unclear. This study aimed to investigate the cross-sectional and longitudinal microstructural alterations in the NBM of patients with iRBD using free-water imaging and whether free water in the NBM is related to cognitive, mood, and autonomic function...
April 9, 2024: Neurology
https://read.qxmd.com/read/38489198/perspectives-of-people-at-risk-on-parkinson-s-prevention-research
#7
REVIEW
Jessi L Keavney, Soania Mathur, Karlin Schroeder, Ray Merrell, Sergio A Castillo-Torres, Virginia Gao, Grace F Crotty, Michael A Schwarzschild, John M Poma
 The movement toward prevention trials in people at-risk for Parkinson's disease (PD) is rapidly becoming a reality. The authors of this article include a genetically at-risk advocate with the LRRK2 G2019 S variant and two patients with rapid eye movement sleep behavior disorder (RBD), one of whom has now been diagnosed with PD. These authors participated as speakers, panelists, and moderators in the "Planning for Prevention of Parkinson's: A Trial Design Forum" hosted by Massachusetts General Hospital in 2021 and 2022...
March 14, 2024: Journal of Parkinson's Disease
https://read.qxmd.com/read/38488114/advancing-patient-centered-care-an-international-survey-of-adolescent-perspectives-on-insomnia
#8
JOURNAL ARTICLE
Sarah M Honaker, Stacey L Simon, Kelly C Byars, Danielle M Simmons, Ariel A Williamson, Lisa J Meltzer
OBJECTIVE: The study objective was to inform patient-centered care for adolescent insomnia by describing adolescents' perspectives on insomnia. Specific constructs of interest included: 1) factors that contributed to insomnia development or maintenance, 2) impact of insomnia on day-to-day life, 3) recommended research priorities, and 4) overall experience living with insomnia. METHOD: A convenience sample of adolescents (ages 13-18 years) self-identifying with insomnia symptoms was recruited through social media...
March 15, 2024: Behavioral Sleep Medicine
https://read.qxmd.com/read/38487572/short-term-chloral-hydrate-as-an-add-on-treatment-may-improve-sleep-and-alleviate-agitation-in-inpatients-with-treatment-resistant-schizophrenia-a-retrospective-case-series-study
#9
JOURNAL ARTICLE
Assaf Shelef, Habashi Alaa, Esther Bloemhof-Bris, Dania Halperin, Shira Weizman, Rafael Stryjer
INTRODUCTION: Chloral hydrate (CH), a medication dating back to 1832, is tranquilizer and sleep promoter still used today. It remains an option for short-term insomnia therapy and sedation before medical procedures, despite its controversial safety profile. METHODS: This study investigated the potential benefits of chloral hydrate addition for increasing sleep duration and reducing agitation and violence in inpatients with treatment-resistant schizophrenia (TRS)...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38484955/zhumian-granules-improves-pcpa-induced-insomnia-by-regulating-the-expression-level-of-neurotransmitters-and-reducing-neuronal-apoptosis
#10
JOURNAL ARTICLE
Yuchen Bao, Hailun Zhou, Yue Fu, Chao Wang, Qinwan Huang
ETHNOPHARMACOLOGICAL RELEVANCE: Sleep problems, according to Traditional Chinese medicine (TCM) philosophy, are attributed to the imbalance between yin and yang. Zhumian Granules, also known as Sleep-aid Granules or ZG, are a traditional Chinese herbal remedy specifically designed to alleviate insomnia. This formula consists of many components, including Wu Wei Zi (Schisandrae Chinensis Fructus), Suan Zao Ren (Ziziphi Spinosae Semen), and other medicinal plants. According to the pharmacology of Traditional Chinese Medicine (TCM), Wu Wei Zi and Suan Zao Ren have the ability to relax the mind and promote sleep...
March 12, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38482885/eeg-spectro-spatial-covariance-patterns-related-to-phenoconversion-in-isolated-rem-sleep-behavior-disorder-and-their-longitudinal-trajectories-in-%C3%AE-synucleinopathies
#11
JOURNAL ARTICLE
Kyoungeun Park, Jung Hwan Shin, Jung-Ick Byun, El Jeong, Han-Joon Kim, Ki-Young Jung
STUDY OBJECTIVES: This study aimed to identify electroencephalographic (EEG) spectro-spatial covariance patterns associated with phenoconversion in isolated rapid eye movement sleep behavior disorder (iRBD) patients and explore their longitudinal trajectories within α-synucleinopathies. METHODS: We assessed 47 participants, including 35 iRBD patients and 12 healthy controls (HC), through baseline eye-closed resting EEGs. iRBD patients underwent follow-up EEG assessments and 18 iRBD patients converted (12 to Parkinson's disease (PD), 6 to dementia with Lewy bodies (DLB)) during follow-up...
March 14, 2024: Sleep
https://read.qxmd.com/read/38482468/dreaming-characteristics-in-non-rapid-eye-movement-parasomnia-and-idiopathic-rapid-eye-movement-sleep-behaviour-disorder-similarities-and-differences
#12
JOURNAL ARTICLE
Qi Rui See, Kausar Raheel, Iain Duncan, Nazanin Biabani, Irene Di Giulio, Andrea Romigi, Veena Kumari, David O'Regan, Scott Cairney, Daniele Urso, K Ray Chaudhuri, Valentina Gnoni, Panagis Drakatos, Ivana Rosenzweig
BACKGROUND: Speech graph analysis (SGA) of dreams has recently shown promise as an objective and language-invariant diagnostic tool that can aid neuropsychiatric diagnosis. Whilst the notion that dreaming mentations reflect distinct physiologic processes is not new, such studies in patients with sleep disorders remain exceptionally scarce. Here, using SGA and other dream content analyses, we set to investigate structural and thematic differences in morning dream recalls of patients diagnosed with Non-Rapid Eye Movement Parasomnia (NREMP) and Idiopathic REM Sleep Behavior Disorder (iRBD)...
2024: Nature and Science of Sleep
https://read.qxmd.com/read/38481452/developmental-trajectories-of-challenging-behaviors-reported-retrospectively-by-japanese-parents-of-adult-children-with-intellectual-disabilities
#13
JOURNAL ARTICLE
Masahiko Inoue, Yoichi Gomi, Soichiro Matsuda
Introduction: Individuals with intellectual disabilities (ID) are at heightened risk of behavioral problems. Methods: This study investigated differences in the severity of challenging behaviors (CBs) among individuals with IDs at varying life stages. Data were collected from parents' retrospective interviews. Surveys were completed by 47 parents whose child with IDs was 19 years or older and had made use of welfare services for individuals who exhibit CBs. Results: The final study sample consisted of 28 parents...
2024: International Journal of Developmental Disabilities
https://read.qxmd.com/read/38479482/microstructural-alterations-of-the-hypothalamus-in-parkinson-s-disease-and-probable-rem-sleep-behavior-disorder
#14
JOURNAL ARTICLE
Cheng Zhou, Jia You, Xiaojun Guan, Tao Guo, Jingjing Wu, Haoting Wu, Chenqing Wu, Jingwen Chen, Jiaqi Wen, Sijia Tan, Xioajie Duanmu, Jianmei Qin, Peiyu Huang, Baorong Zhang, Wei Cheng, Jianfeng Feng, Xiaojun Xu, Linbo Wang, Minming Zhang
BACKGROUND: Whether there is hypothalamic degeneration in Parkinson's disease (PD) and its association with clinical symptoms and pathophysiological changes remains controversial. OBJECTIVES: We aimed to quantify microstructural changes in hypothalamus using a novel deep learning-based tool in patients with PD and those with probable rapid-eye-movement sleep behavior disorder (pRBD). We further assessed whether these microstructural changes associated with clinical symptoms and free thyroxine (FT4) levels...
March 11, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38477376/microglial-activation-and-progression-of-nigrostriatal-dysfunction-in-isolated-rem-sleep-behavior-disorder
#15
JOURNAL ARTICLE
Kristian Staer, Alex Iranzo, Morten Gersel Stokholm, Victor S Hvingelby, Erik Hvid Danielsen, Karen Østergaard, Mónica Serradell, Marit Otto, Kristina B Svendsen, Alicia Garrido, Dolores Vilas, Joan Santamaria, Arne Møller, Carles Gaig, David J Brooks, Per Borghammer, Eduardo Tolosa, Nicola Pavese
BACKGROUND: Using 11 C-(R)-PK11195-PET, we found increased microglia activation in isolated REM sleep behavior disorder (iRBD) patients. Their role remains to be clarified. OBJECTIVES: The objective is to assess relationships between activated microglia and progression of nigrostriatal dysfunction in iRBD. METHODS: Fifteen iRBD patients previously scanned with 11 C-(R)-PK11195 and 18 F-DOPA-PET underwent repeat 18 F-DOPA-PET after 3 years...
March 13, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/38476855/prevalence-of-excessive-daytime-sleepiness-and-its-association-with-daily-life-factors-in-japanese-first-year-university-students
#16
JOURNAL ARTICLE
Hideki Shimamoto, Peter Eastwood, Martin Anderson, Koh Mizuno
As lifestyles have shifted to favor nighttime activities, daytime sleepiness and sleep-related problems have become increasingly common in Japan. Excessive daytime sleepiness (EDS) is an adverse consequence of sleep loss and an important public health concern. EDS may cause academic difficulties, behavioral abnormalities, and psychological dysfunction; therefore, it is a particularly important issue among university students. We conducted a cross-sectional study to investigate the prevalence of EDS and its associated lifestyle factors among Japanese university students...
January 2024: Sleep and Biological Rhythms
https://read.qxmd.com/read/38476186/long-term-intermittent-hypoxia-induces-anxiety-like-behavior-and-affects-expression-of-orexin-and-its-receptors-differently-in-the-mouse-brain
#17
JOURNAL ARTICLE
Huan Tang, Huijie Shen, Zhiyun Ji, Yuheng Hu, Wei Wang, Bin Yan
Studies have revealed a possible connection between orexin, narcolepsy, and obstructive sleep apnea (OSA). Orexin has an important role in the maintenance of arousal and wakefulness/sleeping states. To better understand the pathophysiological mechanism of OSA, we used a chronic intermittent hypoxia (CIH) model in mice to mimic OSA. In this way, we explored the effect of CIH on the locomotor activity and orexin system in the hypothalamus, cerebral cortex, and brainstem of mice. Male C57BL/6 J mice (8 weeks) in the CIH group were exposed in a hypoxia chamber for 8 h/day for 28 weeks...
October 2023: Sleep and Biological Rhythms
https://read.qxmd.com/read/38476183/video-polysomnographic-analysis-of-elevated-emg-activity-and-rapid-eye-movements-before-abnormal-behaviors-in-rem-sleep-behavior-disorder
#18
JOURNAL ARTICLE
Mondo Yoshizawa, Yoshiyuki Tamura, Asami Yasuda-Ohata, Shinsuke Yoshihara, Hideki Takasaki, Sadayuki Hashioka
The pathogenesis of rapid eye movement (REM) sleep behavior disorder (RBD) is unclear. According to the cortical hypothesis, severe RBD episode (RBDE) occurs when spinal motoneurons are less inhibited and cortical and limbic systems are more active. We made this study to prove the hypothesis for the development of RBDE using video-polysomnography (VPSG). VPSG records of 35 patients with RBD were analyzed. According to severity, RBDEs were classified into three motor events (MEs): ME 1; small movements or jerks, ME 2; proximal movements including violent behavior, and ME 3; axial movements including bed falls...
October 2023: Sleep and Biological Rhythms
https://read.qxmd.com/read/38476181/the-effect-of-watching-ott-late-at-night-on-the-sleep-pattern-of-users
#19
JOURNAL ARTICLE
Changjun Lee, Cheongho Na, Keungoui Kim
This study aimed to answer the question of how media users will reallocate their sleep time when their main content channel changes from real-time broadcasting to selective viewing through the over-the-top (OTT) media streaming service. To draw a causal inference between OTT consumption and sleep patterns, the difference-in-difference (DID) estimation method was applied. With the DID approach, a clear distinction between treatment and control groups is essential because the main treatment effects can be screened by the compounding effects...
October 2023: Sleep and Biological Rhythms
https://read.qxmd.com/read/38474214/new-light-on-prions-putative-role-of-prp-c-in-pathophysiology-of-mood-disorders
#20
REVIEW
Adrian Andrzej Chrobak, Patrycja Pańczyszyn-Trzewik, Patrycja Król, Magdalena Pawelec-Bąk, Dominika Dudek, Marcin Siwek
Mood disorders are highly prevalent and heterogenous mental illnesses with devastating rates of mortality and treatment resistance. The molecular basis of those conditions involves complex interplay between genetic and environmental factors. Currently, there are no objective procedures for diagnosis, prognosis and personalization of patients' treatment. There is an urgent need to search for novel molecular targets for biomarkers in mood disorders. Cellular prion protein (PrPc ) is infamous for its potential to convert its insoluble form, leading to neurodegeneration in Creutzfeldt-Jacob disease...
March 4, 2024: International Journal of Molecular Sciences
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