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https://www.readbyqxmd.com/read/18632543/effect-of-simvastatin-on-cognitive-functioning-in-children-with-neurofibromatosis-type-1-a-randomized-controlled-trial
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RANDOMIZED CONTROLLED TRIAL
Lianne C Krab, Arja de Goede-Bolder, Femke K Aarsen, Saskia M F Pluijm, Marlies J Bouman, Jos N van der Geest, Maarten Lequin, Coriene E Catsman, Willem Frans M Arts, Steven A Kushner, Alcino J Silva, Chris I de Zeeuw, Henriƫtte A Moll, Ype Elgersma
CONTEXT: Neurofibromatosis type 1 (NF1) is among the most common genetic disorders that cause learning disabilities. Recently, it was shown that statin-mediated inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase restores the cognitive deficits in an NF1 mouse model. OBJECTIVE: To determine the effect of simvastatin on neuropsychological, neurophysiological, and neuroradiological outcome measures in children with NF1. DESIGN, SETTING, AND PARTICIPANTS: Sixty-two of 114 eligible children (54%) with NF1 participated in a randomized, double-blind, placebo-controlled trial conducted between January 20, 2006, and February 8, 2007, at an NF1 referral center at a Dutch university hospital...
July 16, 2008: JAMA: the Journal of the American Medical Association
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