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Acoustic schwannoma

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https://www.readbyqxmd.com/read/28430338/yap-taz-and-areg-expression-in-eighth-cranial-nerve-schwannoma
#1
Alessandro Martini, Gino Marioni, Elisabetta Zanoletti, Rocco Cappellesso, Roberto Stramare, Elena Fasanaro, Chiara Faccioli, Luciano Giacomelli, Luca Denaro, Domenico D'Avella, Antonio Mazzoni, Ambrogio Fassina
BACKGROUND: Although the diagnosis and treatment of eighth cranial nerve (VIII CN) schwannoma (acoustic neuroma) has improved over the years, no factors capable of predicting tumor growth have been identified as yet. This study is a preliminary investigation of the expression in sporadic VIII CN schwannomas of Yes-associated protein (YAP), transcriptional coactivator with PDZ-binding motif (TAZ), and amphiregulin (AREG), a direct target gene of YAP and TAZ. The expression of YAP, TAZ and AREG was correlated with the volumetric dimensions of tumors on contrast-enhanced magnetic resonance imaging (ceMRI)...
April 7, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28413544/abdominal-schwannoma-in-a-case-of-neurofibromatosis-type-2-a-report-of-a-rare-combination
#2
Khandkar Ali Kawsar, Md Raziul Haque, Forhad Hossain Chowdhury
Neurofibromatosis-2 (NF2) is an autosomal-dominant disease, which is characterized by vestibular schwannomas (VSs) (acoustic neurinoma) as well as tumours of the peripheral and central nervous system, demonstrating a variety of expression. A 12-year-old girl presented to us with headache and ataxia for four months. We examined and found a lump in the right side of her abdomen. On magnetic resonance imaging (MRI) of brain, a bilateral VS at the cerebellopontine (CP) angle was detected, and on computerized tomography (CT) scan and ultrasonography of her abdomen a large retroperitoneal schwannoma was revealed in the right side of her abdomen...
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28394552/multiple-intracranial-schwannomas-case-report
#3
Mario Mihalj, Krešimir Dolić, Pavao Jurinović, Nikolina Ivica Miše, Marina Titlić, Irena Pintarić
Schwannomas are benign encapsulated tumors arising from the sheaths of peripheral nerves. They present as slowly enlarging solitary lumps, which may cause neurological defects. Multiple schwannomas in non-neurofi bromatosis type 2 patients are extremely rare. We report a case of a 60-year-old female patient, without any family history of neurofibromatosis or schwannomatosis, presented with trigeminal neuralgia and progressive facial nerve palsy. Magnetic resonance imaging revealed the presence of acoustic schwannoma involving facial nerve and trigeminal schwannoma of the cisternal part of the nerve involving gasserian ganglion (Meckel’s cave)...
June 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/28371358/hearing-optimization-in-neurofibromatosis-type-2-a-systematic-review
#4
Simon Kingsley Wickham Lloyd, Andrew Thomas King, Scott Alexander Rutherford, Charlotte Lucy Hammerbeck-Ward, Simon Richard MacKenzie Freeman, Deborah Jane Mawman, Martin O'Driscoll, Dafydd Gareth Evans
BACKGROUND: It is common for patients with Neurofibromatosis type 2 to develop bilateral profound hearing loss hearing loss and this is one of the main determinants of quality of life in this patient group. OBJECTIVES: The aim of this systematic review was to review the current literature regarding hearing outcomes of treatments for vestibular schwannomas in neurofibromatosis type 2 including conservative and medical management, radiotherapy, hearing preservation surgery and auditory implantation in order to determine the most effective way of preserving or rehabilitating hearing Search Strategy: A MESH search in PubMed using search terms (("Neurofibromatosis 2"[Mesh]) AND "Neuroma, Acoustic"[Mesh]) AND "Hearing Loss"[Mesh] was performed...
April 1, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28319458/quality-of-life-in-807-patients-with-vestibular-schwannoma-comparing-treatment-modalities
#5
Géke Soulier, Bibian M van Leeuwen, Hein Putter, Jeroen C Jansen, Martijn J A Malessy, Peter Paul G van Benthem, Andel G L van der Mey, Anne M Stiggelbout
Objective In vestibular schwannoma treatment, the choice among treatment modalities is controversial. The first aim of this study was to examine the quality of life of patients with vestibular schwannoma having undergone observation, radiation therapy, or microsurgical resection. The second aim was to examine the relationship between perceived symptoms and quality of life. Last, the association between quality of life and time since treatment was studied. Study Design Cross-sectional study. Setting Tertiary referral center...
March 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28261433/ultrasonographic-and-clinical-characteristics-of-schwannoma-of-the-hand
#6
Seoung Joon Lee, Seok Tae Yoon
BACKGROUND: The purpose of this study was to report the ultrasonographic findings and clinical features of schwannoma of the hand. METHODS: We enrolled 8 patients who were initially diagnosed with ganglion by ultrasonography but finally with schwannoma by a tissue biopsy. We retrospectively analyzed the ultrasonographic findings of eight patients including echogenicity, internal homogeneity, posterior enhancement, internal vascularity, and clinical manifestations such as the occurrence site, tenderness, Tinel's sign, and paresthesia before the surgery...
March 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/28243783/acoustic-schwannoma-with-intracochlear-extension-and-primary-intracochlear-schwannoma-removal-through-translabyrinthine-approach-with-facial-bridge-cochleostomy-and-transcanal-approach
#7
A Mazzoni, E Zanoletti, C Faccioli, A Martini
Intracochlear schwannomas can occur either as an extension of a larger tumor from the internal auditory canal, or as a solitary labyrinthine tumor. They are currently removed via a translabyrinthine approach extended to the basal turn, adding a transotic approach for tumors lying beyond the basal turn. Facial bridge cochleostomy may be associated with the translabyrinthine approach to enable the whole cochlea to be approached without sacrificing the external auditory canal and tympanum. We describe seven cases, five of which underwent cochlear schwannoma resection with facial bridge cochleostomy, one case with the same procedure for a suspect tumor and one, previously subjected to radical tympanomastoidectomy, who underwent schwannoma resection via a transotic approach...
February 27, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28162791/endoscopic-assistance-in-retrosigmoid-transmeatal-approach-to-intracanalicular-vestibular-schwannomas-an-alternative-for-middle-fossa-approach-technical-note
#8
Grzegorz Turek, Carlos Cotúa, Rocio Evangelista Zamora, Marcos Tatagiba
BACKGROUND: Complete surgical removal of intracanalicular vestibular schwannomas with nerve VII and VIII sparing and without worsening patient's status is challenging. Also the choice of an optimal surgical technique, which is usually limited to selection between retrosigmoid transmeatal (RT) and middle fossa (MF) approach, can be a challenge. Although many previous studies documented superiority of RT to MF approach and vice versa, still no consensus has been reached regarding an optimal approach to intracanalicular vestibular schwannomas...
January 19, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28116984/validation-of-the-penn-acoustic-neuroma-quality-of-life-scale-panqol-for-spanish-speaking-patients
#9
Maria Del Mar Medina, Alvaro Carrillo, Ruben Polo, Borja Fernandez, Daniel Alonso, Miguel Vaca, Adela Cordero, Cecilia Perez, Alfonso Muriel, Ignacio Cobeta
Objective To perform translation, cross-cultural adaptation, and validation of the Penn Acoustic Neuroma Quality-of-Life Scale (PANQOL) to the Spanish language. Study Design Prospective study. Setting Tertiary neurotologic referral center. Subjects and Methods PANQOL was translated and translated back, and a pretest trial was performed. The study included 27 individuals diagnosed with vestibular schwannoma. Inclusion criteria were adults with untreated vestibular schwannoma, diagnosed in the past 12 months...
April 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28116456/postoperative-imaging-of-the-internal-auditory-canal-visualization-of-active-auditory-implants
#10
I Todt, G Rademacher, P Mittmann, S Mutze, A Ernst
BACKGROUND: Assessment of the internal auditory canal (IAC) and cochlea is of central importance in neurotology. The artefacts and visibility of active auditory implants on magnetic resonance imaging (MRI) vary because of their specific magnetic components. Knowledge of the size of MRI artefacts and the options for handling them is important for the auditory rehabilitation of specific diseases (e. g., vestibular schwannoma). METHODS: The current article is a literature review...
January 23, 2017: HNO
https://www.readbyqxmd.com/read/28047111/su-f-t-611-critical-analysis-and-efficacy-of-linac-based-beam-modulator-and-cyberknife-treatment-plans-for-acoustic-neuroma-schwannoma
#11
Karrthick Kp, T Kataria, R Thiyagarajan, T Selvan, A Abhishek
PURPOSE: To study the critical analysis and efficacy of Linac and Cyberknife (CK) treatment plans for acoustic neuroma/schwannoma. METHODS: Twelve of acoustic neuroma/schwannoma patients were taken for these study that. Treatment plans were generated in Multiplan treatment planning system (TPS) for CK using 5,7.5 and 10mm diameter collimators. Target volumes were in the range of 0.280 cc to 9.256 cc. Prescription dose (Rx) ranges from 1150cGy to 1950cGy delivered over 1 to 3 Fractions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046895/su-f-t-648-sharpening-dose-fall-off-via-beam-number-enhancements-for-stereotactic-brain-radiosurgery
#12
J Chiu, M Pierce, S Braunstein, M McDermott, P Sneed, L Ma
PURPOSE: Sharp dose fall-off is the hallmark of brain radiosurgery to deliver a high dose of radiation to the target while minimizing dose to normal brain tissue. In this study, we developed a technique for the purpose of enhancing the peripheral dose gradient by magnifying the total number of beams focused toward each isocenter via patient head tilt and simultaneous beam intensity modulations. METHODS: Computer scripting for the proposed beam number enhancement (BNE) technique was developed...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28017747/complications-and-management-of-large-intracranial-vestibular-schwannomas-via-the-retrosigmoid-approach
#13
Xiang Huang, Ming Xu, Jian Xu, Liangfu Zhou, Ping Zhong, Mingyu Chen, Kaiyuan Ji, Huiyu Chen, Ying Mao
OBJECTIVE: To investigate the common complications from the microsurgical treatment of large intracranial vestibular schwannoma (VS) via suboccipital retrosigmoid approach and to propose strategies for minimizing such complications. METHODS: We selected all patients with large unilateral VS from the collected database (1999-2013) who underwent microsurgical resection as their initial treatment for histopathologically confirmed VS. Tumors larger than 30 × 20 mm were defined as large...
March 2017: World Neurosurgery
https://www.readbyqxmd.com/read/27958212/association-of-bilateral-multiple-presumed-retinal-astrocytic-proliferations-with-combined-hamartoma-of-retina-and-retinal-pigment-epithelium-in-a-9-year-old-male-child-with-neurofibromatosis-type-2
#14
Pukhraj Rishi, Raj Shri Hirawat, Aditya Verma
Neurofibromatosis type 2 (NF-2) is characterized by multifocal proliferation of neural crest-derived cells. The characteristics finding of NF-2 is bilateral vestibular schwannomas. Combined hamartoma of retina and retinal epithelium (CHRRPE) is another associated finding. A 9 year-old-male child presented with left eye decreased vision for 3 months. Visual acuity was 0.0 and 0.8 LogMAR in the right and left eye, respectively. Left fundus showed an elevated, pigmented lesion with surface wrinkling and vascular tortuosity suggestive of CHRRPE with multiple presumed retinal astrocytic proliferations in mid-periphery...
November 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27921114/-postoperative-imaging-of-the-internal-auditory-canal-visualization-of-active-auditory-implants-german-version
#15
I Todt, G Rademacher, P Mittmann, S Mutze, A Ernst
BACKGROUND: Assessment of the internal auditory canal (IAC) and the cochlea is of central importance in neurotology. The artefacts and visibility of the different types of active auditory implants in MRI vary, due to their specific ferromagnetic components. Knowledge of the size of MRI artefacts and the options for handling these is important for the auditory rehabilitation of specific diseases (e. g., vestibular schwannoma). METHODS: The current paper is a literature review RESULTS: MRI assessment of the IAC and cochlea after surgical placement of an active auditory implant is feasible only with a percutaneous bone-anchored hearing aid (BAHA, Ponto)...
December 5, 2016: HNO
https://www.readbyqxmd.com/read/27858100/-early-acoustic-evoked-potentials-in-patients-with-small-vestibular-schwannomas
#16
I Baljić, E Börner-Lünser, D Eßer, O Guntinas-Lichius
BACKGROUND: The prognostic potential of click-evoked early acoustic evoked potentials (EAEP) for vestibular schwannoma (VS) diagnostics is considered insufficient for tumors small than approximately <1.5 cm in diameter. However, up until now, the derivations at higher sound pressure levels have mainly been used for EAEP evaluation. The aim of this study was to examine whether registered EAEP are more sensitive to pathological changes at low sound pressure levels and with smaller tumors...
November 17, 2016: HNO
https://www.readbyqxmd.com/read/27815992/contralateral-hearing-loss-and-facial-palsy-in-an-operated-case-of-vestibular-schwannoma-case-report
#17
Abhijit Warade, Pawan Chawla, Anshu Warade, Ketan Desai
INTRODUCTION: Contralateral ear hearing loss (CHL) is an extremely rare but a potentially devastating complication in a patient with already compromised hearing due to a Vestibular schwannoma (VS). Our patient had CHL accompanied by contralateral facial palsy. Our case is only the second case reported in literature to the best of our knowledge. PRESENTATION OF CASE: A 55-year elderly male presented with right sided sensorineural hearing loss, cerebellar signs and Grade II House & Brackmann (H&B) facial nerve weakness for last1-year...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27755456/diagnostic-criteria-for-detection-of-vestibular-schwannomas-in-the-va-population
#18
Israel Pena, Erin Y Chew, Barcleigh P Landau, Joseph T Breen, Jose P Zevallos, Jeffrey T Vrabec
OBJECTIVE: To investigate the prevalence of vestibular schwannoma (VS) and asymmetric sensorineural hearing loss in the Veterans Administration hospital population and analyze a more efficient method of diagnosing VS in a population with significant noise exposure. STUDY DESIGN: Retrospective review of South Central (VISN 16) Veterans Administration hospitals. METHODS: Record query for ICD-9 codes for asymmetric sensorineural hearing loss or VS between 1999 and 2012...
December 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27738538/neurofibromatosis-type-2-presenting-with-oculomotor-ophthalmoplegia-and-distal-myopathy
#19
Jessica Mani Penny Tevaraj, Evelyn Tai Li Min, Raja Azmi Mohd Noor, Azhany Yaakub, Wan Hazabbah Wan Hitam
Neurofibromatosis type 2 usually presents with bilateral acoustic schwannomas. We highlight the rare presentation of neurofibromatosis initially involving third nerve. A 23-year-old Malay female presented with left eye drooping of the upper lid and limitation of upward movement for 8 years. It was associated with right-sided body weakness, change in voice, and hearing disturbance in the right ear for the past 2 years. On examination, there was mild ptosis and limitation of movement superiorly in the left eye...
2016: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/27675473/inherent-functional-dependence-among-cochlear-dose-surrogates-for-stereotactic-radiosurgery-of-acoustic-schwannomas
#20
L Ma, S E Braunstein, P Theodosopoulos, M W McDermott, P K Sneed
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
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