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https://www.readbyqxmd.com/read/28541397/prevalence-and-co-occurrence-of-geriatric-syndromes-in-people-aged-75-years-and-older-in-france-results-from-the-bordeaux-three-city-study
#1
Maturin Tabue-Teguo, Leslie Grasset, José Alberto Avila-Funes, Robin Genuer, Cecile Proust-Lima, Karine Péres, Catherine Féart, Hélène Amieva, Magali González-Colaço Harmand, Catherine Helmer, Nathalie Salles, Muriel Rainfray, Jean François Dartigues
Background: Geriatric syndromes (GSs) are often the result of cumulative insults to multiple organ systems and are considered common in older adults. However, their frequency and co-occurrence are not well known in the elderly population. This study aimed to determine the prevalence of several GSs and to analyze the co-occurrence of these syndromes in a general population of elderly individuals. Methods: A cross-sectional analysis of 630 adults aged 75 years or older participating in the 10-year follow-up of the Bordeaux sample of the French Three-City Study was conducted...
May 24, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28489142/cognitive-cooperation-groups-mediated-by-computers-and-internet-present-significant-improvement-of-cognitive-status-in-older-adults-with-memory-complaints-a-controlled-prospective-study
#2
Rodrigo de Rosso Krug, Anna Quialheiro Abreu da Silva, Ione Jayce Ceola Schneider, Luiz Roberto Ramos, Eleonora d'Orsi, André Junqueira Xavier
Objective: To estimate the effect of participating in cognitive cooperation groups, mediated by computers and the internet, on the Mini-Mental State Examination (MMSE) percent variation of outpatients with memory complaints attending two memory clinics. Methods: A prospective controlled intervention study carried out from 2006 to 2013 with 293 elders. The intervention group (n = 160) attended a cognitive cooperation group (20 sessions of 1.5 hours each). The control group (n = 133) received routine medical care...
April 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28346888/oxidative-and-nitrosative-stress-biomarkers-in-chronic-schizophrenia
#3
Karine Maria Boll, Cristiano Noto, Kamila Landucci Bonifácio, Chiara Cristina Bortolasci, Ary Gadelha, Rodrigo Affonseca Bressan, Décio Sabbatini Barbosa, Michael Maes, Estefania Gastaldello Moreira
There is evidence that the acute phase of schizophrenia (SCZ) is accompanied by specific changes in oxidative and nitrosative stress (O&NS) biomarkers. There are, however, no firm data regarding these biomarkers in chronic SCZ. Therefore, this study aimed to delineate O&NS biomarkers in patients with chronic SCZ. 125 outpatients with SCZ and 118 controls were enrolled. The markers included lipid hydroperoxides (LOOH), advanced oxidation protein products (AOPP), nitric oxide metabolites (NOx), total radical-trapping antioxidant parameter (TRAP) and paraoxonase 1 (PON-1) activity...
March 21, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28251277/hospital-admissions-due-to-adverse-drug-reactions-in-the-elderly-a-meta-analysis
#4
T J Oscanoa, F Lizaraso, Alfonso Carvajal
INTRODUCTION: It is currently admitted that adverse drug reactions (ADRs) account for a great burden of disease. Of particular concern are ADR-induced hospital admissions, particularly in the elderly; they receive most of the medications and they are the most prone to develop ADRs. Therefore, our aim was to carry out a study of ADR-induced hospital admissions focused on the elderly population. METHODS: For the purpose, a systematic review and meta-analysis was performed of those studies addressing ADR-induced hospital admissions in patients over 60 years of age...
March 1, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28215652/polypathology-polypharmacy-medication-regimen-complexity-and-drug-therapy-appropriateness
#5
N Gómez Aguirre, A Caudevilla Martínez, L Bellostas Muñoz, M Crespo Avellana, J Velilla Marco, J Díez-Manglano
Polypathological patients are usually elderly and take numerous drugs. Polypharmacy affects 85% of these individuals and is not associated with greater survival. On the contrary, polypharmacy exposes these individuals to more adverse effects, such as weight loss, falls, functional and cognitive impairment and hospitalisations. The complexity of a drug regimen covers more aspects than the simple number of drugs consumed. The galenic form, the dosage and the method for preparing the drug can impede the understanding of and compliance with prescriptions...
February 16, 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/28125977/supporting-clinical-rules-engine-in-the-adjustment-of-medication-scream-protocol-of-a-multicentre-prospective-randomised-study
#6
Carlota Mestres Gonzalvo, Hugo A J M de Wit, Brigit P C van Oijen, Kim P G M Hurkens, Rob Janknegt, Jos M G A Schols, Wubbo J Mulder, Frans R Verhey, Bjorn Winkens, Paul-Hugo M van der Kuy
BACKGROUND: In the nursing home population, it is estimated that 1 in every 3 patients is polymedicated and given their considerable frailty, these patients are especially prone to adverse drug reactions. Clinical pharmacist-led medication reviews are considered successful interventions to improve medication safety in the inpatient setting. Due to the limited available evidence concerning the benefits of medication reviews performed in the nursing home setting, we propose a study aiming to demonstrate a positive effect that a clinical decision support system, as a health care intervention, may have on the target population...
January 26, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28101101/predictive-factors-of-rapid-cognitive-decline-in-patients-with-alzheimer-disease
#7
Coralie Barbe, Isabella Morrone, J L Novella, Moustapha Dramé, Aurore Wolak-Thierry, Jean-Pierre Aquino, Joël Ankri, Damien Jolly, Rachid Mahmoudi
AIM: To determine predictive factors associated with rapid cognitive decline (RCD) in elderly patients suffering from Alzheimer disease (AD). METHODS: Patients suffering from mild to moderate AD were included. RCD was defined as the loss of at least 3 points on the Mini-Mental State Examination (MMSE) over 12 months. Factors associated with RCD were identified by logistic regression. RESULTS: Among 123 patients included, 61 were followed up until 12 months...
September 2016: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28058574/quality-of-life-with-rivaroxaban-in-patients-with-non-valvular-atrial-fibrilation-by-therapeutic-compliance
#8
Emilio Márquez-Contreras, Nieves Martell-Claros, Vicente Gil-Guillén, Mariano De la Figuera-Von Wichmann, Eugenio Sánchez-López, Ines Gil-Gil, Sara Márquez-Rivero
OBJECTIVE: To assess the quality of life (QOL) with rivaroxaban in patients with non-valvular atrial fibrilation (NVAF) related to therapeutic compliance. METHODS: Prospective, longitudinal, multicenter study was developed in 160 Spanish primary or specialized care centers. We included 412 patients treated with rivaroxaban, prescribed for stroke prevention. Three visits were conducted: baseline, 6 and 12 months. Compliance was measured by electronic monitoring systems...
January 6, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28042791/profile-of-oab-patient-on-treatment-with-flexible-dose-antimuscarinic-drugs-in-daily-clinical-practice
#9
MULTICENTER STUDY
Francisco Sánchez-Ballester, Jose María García-Mediero, Marcos Sobrón-Bustamante, Isabel Lizarraga, Daniel Arumi
OBJECTIVE: To describe the profile of the overactive bladder (OAB) patient on treatment with flexible-dose antimuscarinic treatment in daily clinical practice. METHODS: This was an observational, retrospective and multicenter study, carried out at 88 public and private hospitals. Adult patients diagnosed with OAB who initiated flexible-dose antimuscarinic treatment. Type of antimuscarinic, dose, concomitant treatments, treatment benefit and treatment adherence were recorded...
December 2016: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/27978469/highly-sensitive-lc-ms-ms-methods-for-the-determination-of-seven-human-cyp450-activities-using-small-oral-doses-of-probe-drugs-in-human
#10
Alexia Grangeon, Sophie Gravel, Fleur Gaudette, Jacques Turgeon, Veronique Michaud
Cocktails composed of several Cytochrome P450 (CYP450)-selective probe drugs have been shown of value to characterize in vivo drug-metabolism activities. Our objective was to develop and validate highly sensitive and selective LC-MS/MS assays allowing the determination of seven major human CYP450 isoenzyme activities following administration of low oral doses of a modified CYP450 probe-drug cocktail in patients. The seven-drug cocktail was composed of caffeine, bupropion, tolbutamide, omeprazole, dextromethorphan, midazolam (all administered concomitantly) and chlorzoxazone (administered separately) to phenotype for CYP1A2, 2B6, 2C9, 2C19, 2D6, 3A4/5 and 2E1, respectively...
January 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27925256/pharmacokinetic-drug-drug-interactions-of-tyrosine-kinase-inhibitors-a-focus-on-cytochrome-p450-transporters-and-acid-suppression-therapy
#11
REVIEW
Caroline Gay, Delphine Toulet, Pascal Le Corre
The extensive use of tyrosine kinase inhibitors (TKI's) in hematology and oncology has shown that these drugs have a significant potential for drug-drug interactions. Since these drugs have a rather low therapeutic window, some drug interactions are of particular clinical relevance either on drug toxicity or on patient's response. Significant interactions occur with concomitant use of acid-suppressive therapy leading to a decreased oral bioavailability. However, such interactions are drug dependent according to their solubility pattern and to the duration of action of acid-suppressive therapy, which is coprescribed...
December 7, 2016: Hematological Oncology
https://www.readbyqxmd.com/read/27894227/multidisciplinary-teams-involved-detection-of-drug-related-problems-through-continuity-of-care
#12
Elena Yaiza Romero-Ventosa, Marisol Samartín-Ucha, Alicia Martín-Vila, María Lucía Martínez-Sánchez, Isabel Rey Gómez-Serranillos, Guadalupe Pineiro-Corrales
OBJECTIVE: To quantify Drug-Related problems (DRPs) by establishing a Strategic Continuity of Care Program (e-Conecta- Concilia Program; e-CC) focused on the drug therapy of patients within an Integrated Management Structure, in order to guarantee the therapeutical efficiency, safety and traceability of patients. METHOD: A prospective study at 8 months. The project included 22 Hospital Pharmacists and 12 Primary Care Pharmacists. Electronic clinical records were used, which can be accessed by all healthcare levels...
November 1, 2016: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/27701129/biomechanical-skin-property-evaluation-for-wounds-treated-with-synthetic-and-biosynthetic-wound-dressings-and-a-newly-developed-collagen-matrix-during-healing-of-superficial-skin-defects-in-a-rat-models
#13
Manuel Held, Anne-Sophie Engelke, Dascha Sophie Tolzmann, Afshin Rahmanian-Schwarz, Hans-Eberhard Schaller, Jens Rothenberger
INTRODUCTION: There is a high prevalence of superficial wounds such as partial-thickness burns. Treatment of these wounds frequently includes temporary application of wound dressings. The aim of this study was to compare a newly developed collagen matrix with commonly used temporary skin dressings for treatment of partial-thickness skin defects. MATERIALS AND METHODS: Through a skin dermatome, 42 standardized superficial skin defects were generated on the back of 28 adult male Lewis rats...
September 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/27651004/prevalence-and-related-factors-of-ineffective-self-health-management-in-polymedicated-patients-over-the-age-of-65-years
#14
Alonso Montiel-Luque, Antonio Jesús Núñez-Montenegro, Esther Martín-Aurioles, Felicísima García-Dillana, Maria Carmen Toro-Toro, José Antonio González-Correa
PURPOSE: To determine the prevalence of Ineffective Self-Health Management (ISHM) (00078) and its related factors in polymedicated patients over the age of 65 years. METHODS: A cross-sectional, descriptive design was used. A home interview was conducted with each participant (N = 375) for data collection. FINDINGS: The prevalence of ISHM was 37.3%. The risk factors associated were social risk, depression, noncompliance, medication errors, and confusion with medications...
September 21, 2016: International Journal of Nursing Knowledge
https://www.readbyqxmd.com/read/27605543/randomized-controlled-trial-of-an-intervention-to-improve-drug-appropriateness-in-community-dwelling-polymedicated-elderly-people
#15
Lluís Campins, Mateu Serra-Prat, Inés Gózalo, David López, Elisabet Palomera, Clara Agustí, Mateu Cabré
BACKGROUND: Polypharmacy is frequent in the elderly population and is associated with potentially drug inappropriateness and drug-related problems. OBJECTIVES: To assess the effectiveness and safety of a medication evaluation programme for community-dwelling polymedicated elderly people. DESIGN: Randomized, open-label, multicentre, parallel-arm clinical trial with 1-year follow-up. SETTING: Primary care centres. PARTICIPANTS: Polymedicated (≥8 drugs) elderly people (≥70 years)...
February 2017: Family Practice
https://www.readbyqxmd.com/read/27598380/drug-drug-interactions-and-adverse-drug-reactions-in-polypharmacy-among-older-adults-an-integrative-review
#16
Maria Cristina Soares Rodrigues, Cesar de Oliveira
OBJECTIVE: to identify and summarize studies examining both drug-drug interactions (DDI) and adverse drug reactions (ADR) in older adults polymedicated. METHODS: an integrative review of studies published from January 2008 to December 2013, according to inclusion and exclusion criteria, in MEDLINE and EMBASE electronic databases were performed. RESULTS: forty-seven full-text studies including 14,624,492 older adults (≥ 60 years) were analyzed: 24 (51...
September 1, 2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27553047/aging-gracefully-in-greater-beirut-are-there-any-gender-based-differences
#17
Rosy N Mitri, Christa M Boulos, Salim M Adib
BACKGROUND: The implications of rapid aging of the Lebanese population are under-researched. No national studies have so far investigated the living conditions and the health status of urban Lebanese elderly across gender. METHODS: This was a cross-sectional study involving 905 randomly selected community dwelling elderly aged ≥65 years living in Greater Beirut. Gender differences were assessed among participants who completed a standardized questionnaire on socio-demographic factors, nutritional, health, and functional characteristics...
August 23, 2016: European Journal of Public Health
https://www.readbyqxmd.com/read/27524210/drug-prescribing-in-the-elderly-receiving-home-care
#18
Chien-Han Tsao, Chin-Feng Tsai, Yuan-Ti Lee, Mao-Chung Weng, Huei-Chao Lee, Ding-Bang Lin, Chun-Chieh Chen, Meng-Chih Lee, Shiuan-Chih Chen
BACKGROUND: To compare the prevalence of potentially inappropriate medications (PIMs) using the 2012 and 2003 Beers Criteria in frail older patients receiving home health care services (HHS), and to explore the correlates of PIMs based on the 2012 Beers criteria. MATERIALS AND METHODS: A total of 145 older patients (mean age, 80.9 ± 7.6 years) with Barthel scale ≤ 60 receiving regular HHS from a university hospital between January 2013 and June 2013 were retrospectively enrolled...
August 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27503566/a-comparative-study-between-two-sensory-stimulation-strategies-after-two-weeks-treatment-on-older-patients-with-oropharyngeal-dysphagia
#19
Omar Ortega, Laia Rofes, Alberto Martin, Viridiana Arreola, Irene López, Pere Clavé
Oropharyngeal dysphagia (OD) is a prevalent geriatric syndrome. Treatment is based on compensatory strategies to avoid complications. New treatments based on sensory stimulation to promote the recovery of the swallowing function have proved effective in acute studies but prolonged treatment needs further research. Our aim was to evaluate and compare the effect of two, longer-term sensory treatment strategies on older patients with OD. 38 older patients (≥70 years) were studied with videofluoroscopy (pre/posttreatment) and randomized into two 10-day treatment groups: Group A-transient receptor potential vanilloid 1 (TRPV1) agonist (capsaicin 1 × 10(-5) M) and Group B-transcutaneous sensory electrical stimulation (TSES) (Intelect VitalStim, biphasic pulses, 300 μs, 80 Hz)...
October 2016: Dysphagia
https://www.readbyqxmd.com/read/27491880/nanofibrillar-cellulose-wound-dressing-in-skin-graft-donor-site-treatment
#20
T Hakkarainen, R Koivuniemi, M Kosonen, C Escobedo-Lucea, A Sanz-Garcia, J Vuola, J Valtonen, P Tammela, A Mäkitie, K Luukko, M Yliperttula, H Kavola
BACKGROUND: Although new therapeutic approaches for burn treatment have made progress, there is still need for better methods to enhance wound healing and recovery especially in severely burned patients. Nanofibrillar cellulose (NFC) has gained attention due to its renewable nature, good biocompatibility and excellent physical properties that are of importance for a range of applications in pharmaceutical and biomedical fields. In the present study, we investigated the potential of a wood based NFC wound dressing in a clinical trial on burn patients...
December 28, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
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