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https://www.readbyqxmd.com/read/29784546/complexity-of-the-medication-regimen-for-polypathological-patients
#1
L Bellostas-Muñoz, J Díez-Manglano
OBJECTIVE: To determine the complexity of the therapeutic regimen for polypathological patients hospitalised in internal medicine departments. METHODS: A multicentre observational study included polypathological patients hospitalised in internal medicine departments. Patients who were readmitted or died were excluded. Data were collected on age, sex, residence, disease, Charlson, Barthel and Lawton-Brody indices, Pfeiffer questionnaire, Gijón scale, number of hospitalisations in the previous year, delirium, need for and availability of caregivers and the PROFUND index score...
May 18, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29739318/safety-of-cilostazol-in-peripheral-artery-disease-a-cohort-from-a-primary-healthcare-electronic-database
#2
Jordi Real, M Catalina Serna, Maria Giner-Soriano, Rosa Forés, Guillem Pera, Esther Ribes, Maite Alzamora, Josep Ramon Marsal, Antonio Heras, Rosa Morros
BACKGROUND: Cilostazol has been associated with spontaneous reports of cardiovascular adverse events and serious bleeding. The objective of this study is to determine the relative risk of cardiovascular adverse events or haemorrhages in patients with peripheral artery disease treated with cilostazol in comparison to pentoxifylline users. METHODS: Population-based cohort study including all individuals older than 40 who initiated cilostazol or pentoxifylline during 2009-2011 in SIDIAP database...
May 8, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29737468/potential-drug-drug-interactions-in-a-cohort-of-elderly-polymedicated-primary-care-patients-on-antithrombotic-treatment
#3
Katharina Luise Schneider, Kathrin Kastenmüller, Klaus Weckbecker, Markus Bleckwenn, Miriam Böhme, Julia Carolin Stingl
INTRODUCTION: Drug-drug interactions (DDIs) are an important risk factor for adverse drug reactions. Older, polymedicated patients are particularly affected. Although antithrombotics have been detected as high-risk drugs for DDIs, data on older patients exposed to them are scarce. METHODS: Baseline data of 365 IDrug study outpatients (≥ 60 years, use of an antithrombotic and one or more additional long-term drug) were analyzed regarding potential drug-drug interactions (pDDIs) with a clinical decision support system...
May 8, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29714617/pharmacotherapeutic-reports-as-tools-for-detecting-discrepancies-in-continuity-of-care
#4
Elena Yaiza Romero-Ventosa, Mónica Gayoso-Rey, Marisol Samartín-Ucha, Pablo Lamas-Domínguez, Martín Rubianes-González, David Rodríguez-Lorenzo, María Holanda Rodríguez-Vázquez, Julio García-Comesaña, Guadalupe Piñeiro-Corrales
BACKGROUND: The care transition is the time when more medication errors occur. The aim of this study is to analyze the usefulness of a pharmacotherapeutic report model at hospital discharge to prevent medication errors and to simplify pharmacotherapy during a patient's transition from the hospital to primary care. METHODS: Prospective study including patients diagnosed with chronic obstructive pulmonary disease who were admitted to a short-stay unit or an emergency room...
January 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29623408/-thromboembolism-prophylaxis-in-old-age
#5
Gabriele Röhrig, Gerald Kolb
Anticoagulation in geriatric patients is challenging regarding the risk of bleeding complications and thromboembolic problems. Age, comorbidities, such as renal insufficiency and polymedication have a vital impact on bleeding and thromboembolic risks; however, age is not an exclusion criterion for withholding anticoagulation. Age is the main risk factor for deep vein thrombosis and atrial fibrillation becomes more relevant with aging. Older patients with atrial fibrillation have a particularly high risk of having a stroke...
April 2018: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29572039/blood-zinc-levels-and-cognitive-and-functional-evaluation-in-non-demented-older-patients
#6
Tobías E Rivas-García, Marta Marcelo-Pons, Francisco Martínez-Arnau, Nuria Serra-Catalá, Y Santamaría-Carrillo, Omar Cauli
A complete battery of geriatric and psychometric tests was used to determine whether plasma-borne zinc (Zn), a key ion in neuroplasticity, can be associated with the severity of functional, psychological and cognitive impairment in non-demented older individuals. There was a significant positive correlation between plasma Zn levels and the concentration subcategory measured with the Mini-Mental State Examination (MMSE) test (p < 0.001), but not the total MMSE score, and the levels were significantly reduced in polymedicated patients (defined as concurrent administration of >5 drugs)...
March 20, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29570971/phenotypic-assessment-of-drug-metabolic-pathways-and-p-glycoprotein-in-patients-treated-with-antidepressants-in-an-ambulatory-setting
#7
Célia Lloret-Linares, Marija Bosilkovska, Youssef Daali, Marianne Gex-Fabry, Kyle Heron, Victor Bancila, Giorgio Michalopoulos, Nader Perroud, Hélène Richard-Lepouriel, Jean-Michel Aubry, Jules Desmeules, Marie Besson
OBJECTIVE: Drug-metabolizing enzymes (DMEs), such as cytochrome P450 (CYP) enzymes, and transporters have emerged as major determinants of variability in drug metabolism and response. This study investigated the association between CYP and P-glycoprotein activities and plasma antidepressant concentration in an outpatient clinical setting. Secondary outcomes were antidepressant efficacy and tolerance. We also describe phenotypes in patients treated with antidepressants and evaluate the tolerance of a minimally invasive phenotyping approach...
March 20, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29497282/satisfaction-with-oral-anticoagulants-in-patients-with-atrial-fibrillation
#8
Carmen Suárez Fernández, Luis Castilla-Guerra, Jesus Cantero Hinojosa, Josep Maria Suriñach, Fernando Acosta de Bilbao, Juan José Tamarit, José Luis Diaz Diaz, Jose Luis Hernandez, Antonio Pose, Manuel Montero-Pérez-Barquero, Jaume Roquer, Jaime Gállego, José Vivancos, Jose María Mostaza
Background: Although, by itself, atrial fibrillation is associated with an impairment of quality of life antithrombotic therapy may play a role. Objective: To evaluate the satisfaction with anticoagulant treatment in patients with nonvalvular atrial fibrillation who attended internal medicine departments in Spain. Methods: Patients from two different cross-sectional studies were combined. To measure the satisfaction with anticoagulant treatment, the Anti-Clot-Treatment Scale (ACTS) questionnaire was completed by every patient...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29464465/the-concomitant-use-of-lapatinib-and-paracetamol-the-risk-of-interaction
#9
Agnieszka Karbownik, Edyta Szałek, Katarzyna Sobańska, Tomasz Grabowski, Agnieszka Klupczynska, Szymon Plewa, Anna Wolc, Magdalena Magiera, Joanna Porażka, Zenon J Kokot, Edmund Grześkowiak
Lapatinib is a tyrosine kinase inhibitor used for the treatment of breast cancer. Paracetamol is an analgesic commonly applied to patients with mild or moderate pain and fever. Cancer patients are polymedicated, which involves high risk of drug interactions during therapy. The aim of the study was to assess the interaction between lapatinib and paracetamol in rats. The rats were divided into three groups of eight animals in each. One group received lapatinib + paracetamol (IL + PA ), another group received lapatinib (IIL ), whereas the last group received paracetamol (IIIPA )...
February 20, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29457009/acneiform-rash-caused-by-an-unlikely-drug-topiramate
#10
Yesenia Bello-Hernández, Jessica Espinoza-Hernández, Gabriela Moreno-Coutiño
Topiramate is an antiepileptic drug that can also be used for migraine prophylaxis, weight control, and even for methamphetamine dependence; the dosage margin is wide, and the list of side effects is shorter than with other anticonvulsants. We present the case of a 35-year-old man with a disseminated rash of the trunk and extremities after treatment with 25 mg of topiramate daily as a prophylactic migraine treatment. This case report is useful, as this patient was not polymedicated and had a score of 7 on the Naranjo Adverse Drug Reaction Probability Scale...
January 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29441963/do-patients-with-diabetes-type-2-or-chronic-heart-failure-understand-a-medication-plan
#11
L Botermann, A Wachter, K Monzel, K Krueger, S Ewen, F Mahfoud, N Griese-Mammen, M Schulz, U Laufs
A standardized medication plan (MP) was recently enacted into German law (§ 31a SGB V). The purpose of our study was to assess if patients with chronic diseases requiring polymedication understand the standardized MP and can transfer the given information into practice. 100 patients who took at least five medicines regularly were prospectively included in a cross-sectional study: 50 patients with the primary diagnosis chronic heart failure (CHF), and 50 with diabetes mellitus type 2 (DMT2). We performed a structured test-scenario studying the handling of a provided MP then evaluated the execution of the information on the MP by filling pill boxes and requested patients' opinion...
December 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29439425/inappropriate-use-of-medication-by-elderly-polymedicated-or-multipathological-patients-with-chronic-diseases
#12
REVIEW
Virtudes Pérez-Jover, José J Mira, Concepción Carratala-Munuera, Vicente F Gil-Guillen, Josep Basora, Adriana López-Pineda, Domingo Orozco-Beltrán
The growth of the aging population leads to the increase of chronic diseases, of the burden of multimorbility, and of the complexity polypharmacy. The prevalence of medication errors rises in patients with polypharmacy in primary care, and this is a major concern to healthcare systems. This study reviews the published literature on the inappropriate use of medicines in order to articulate recommendations on how to reduce it in chronic patients, particularly in those who are elderly, polymedicated, or multipathological...
February 10, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29325730/use-of-cardiovascular-polypills-for-the-secondary-prevention-of-cerebrovascular-disease
#13
J Masjuan, J Gállego, J M Aguilera, J F Arenillas, M Castellanos, F Díaz, J C Portilla, F Purroy
INTRODUCTION: There is little control of cardiovascular (CV) risk factors in secondary prevention after an ischaemic stroke, in part due to a lack of adherence to treatment. The CV polypill may contribute to proper treatment adherence, which is necessary for CV disease prevention. This study aimed to establish how and in what cases the CV polypill should be administered. METHODS: A group of 8 neurologists drafted consensus recommendations using structured brainstorming and based on their experience and a literature review...
January 8, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29316126/fixed-dose-combination-therapy-to-reduce-the-growing-burden-of-cardiovascular-disease-in-low-and-middle-income-countries-feasibility-and-challenges
#14
REVIEW
Jobert Richie Nansseu, Aurel T Tankeu, Joseph Kamtchum-Tatuene, Jean Jacques Noubiap
Cardiovascular disease (CVD) has become a major concern in low- and middle-income countries, which bear about 80% of the cardiovascular mortality worldwide. Curbing the burden of CVD implies the management and control of many cardiovascular risk factors that act synergistically to increase cardiovascular mortality. Such actions may require expensive polymedications in a context of limited resources. Therefore, alternative solutions for CVD prevention in low- and middle-income countries are urgently needed. In this context, the concept of a fixed-dose combination therapy, a polypill composed of drugs known to effectively treat or prevent CVD, has been proposed as a scalable strategy to overcome nonadherence to polymedications and reduce costs...
January 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29235430/prevalence-and-risk-factors-for-delirium-diagnosis-in-patients-followed-in-general-practices-in-germany
#15
Jens Bohlken, Karel Kostev
BACKGROUND: The aim of this study is to identify the prevalence and risk factors of documented delirium in general practices in Germany. METHODS: The present study includes 2,194 patients over the age of 65 years with delirium and 2,194 controls without delirium from a sample of 6,180,042 patients from 1,262 general practices. Multivariate logistic regression models were fitted with delirium as a dependent variable and other disorders and drugs as potential predictors...
December 13, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29203430/optimization-of-perioperative-management-of-proximal-femoral-fracture-in-the-elderly
#16
REVIEW
P Merloz
Proximal femoral fracture in elderly subjects is a major event that is life-threatening in the medium-to-long term. Advanced age, male gender and number of comorbidities largely account for high mortality and require geriatric expertise. Protein-energy malnutrition and bone demineralization increase mortality. Mortality can, on the other hand, be reduced by acting on two variables accessible to medical intervention: daily activities and nutritional status. Functional and neurocognitive assessment allow the risk of dependency to be evaluated, and global geriatric work-up can prevent sudden breakdown of homeostasis...
February 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29187329/impact-of-therapeutic-education-with-a-written-document-on-treatments-knowledge-and-adherence-among-elderly-patients-results-of-a-pilot-study
#17
Claire Vanhaecke Collard, Laetitia Michaut, Florian Caillierez, Daniel Parra, Marc Bonnefoy
Olders patients are exposed to iatrogenic risk as they are often frail, with multiple pathologies and therefore polymedicated. The objective of this study was to evaluate the knowledge of treatment in the elderly before and after a time of oral therapeutic education accompanied by the submission of a written educational support. The impact of that education on the adhesion was also evaluated. METHODS: We've included patients aged at least 75 years old, living at home, and managing themselves their treatment...
December 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/29162290/reduction-of-pharmaceutical-expenditure-by-a-drug-appropriateness-intervention-in-polymedicated-elderly-subjects-in-catalonia-spain
#18
Lluís Campins, Mateu Serra-Prat, Elisabet Palomera, Ignasi Bolibar, Miquel Àngel Martínez, Pedro Gallo
OBJECTIVE: To assess the monetary savings resulting from a pharmacist intervention on the appropriateness of prescribed drugs in community-dwelling polymedicated (≥8 drugs) elderly people (≥70 years). METHOD: An evaluation of pharmaceutical expenditure reduction was performed within a randomised, multicentre clinical trial. The study intervention consisted of a pharmacist evaluation of all drugs prescribed to each patient using the "Good Palliative-Geriatric Practice" algorithm and the "Screening Tool of Older Persons Prescriptions/Screening Tool to Alert doctors to Right Treatment" criteria (STOPP/START)...
November 18, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/29157110/risk-factors-and-clinical-outcomes-of-delirium-in-osteoporotic-hip-fractures
#19
Joon Yub Kim, Jeong Hyun Yoo, Eugene Kim, Ki Bum Kwon, Byeong-Ryong Han, Yongun Cho, Jai Hyung Park
PURPOSE: This study is performed to identify risk factors for delirium in osteoporotic hip fractures and to evaluate the hospitalization cost and clinical outcomes of delirium in osteoporotic hip. METHODS: A total of 221 patients with osteoporotic hip fractures were assessed for eligibility between 2010 and 2014. Among them, 37 patients with delirium were allocated into the delirium group (group D) and 37 patients without delirium were allocated into the non-delirium group (group ND) by matching demographic factors...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29126634/-antiepileptic-drugs-administration-by-nasogastric-tube-in-comatose-patients
#20
Rim Charfi, Ramla Mizouri, Mouna Ben Sassi, Emna Gaies, Hanene Eljebari, Nadia Jebabli, Sarrah Zereï, Fatma Ben Salem, Dorra Ben Said, Anis Klouz, Riadh Daghfous, Issam Salouage, Sameh Trabelsi
AIM: To evaluate the modalities of administration of antiepileptic drugs (AED) with nasogastric tube (NGT) by nurses and to draw up recommendations. METHODS: Our study consisted on investigating the modalities of administration of AED's with NGT by nurses during four months. We prepared 10 questions including demographic information. Participation was voluntary and anonymous. The questionnaire was distributed in seven intensive care departments after authorization of each head of the department...
October 12, 2017: Thérapie
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