Frank A Sinicrope, Garth D Nelson, Bahar Saberzadeh-Ardestani, Diana I Segovia, Rondell P Graham, Christina Wu, Catherine E Hagen, Sameer Shivji, Paul Savage, Dan D Buchanan, Mark A Jenkins, Amanda I Phipps, Carol Swallow, Loic LeMarchand, Steven Gallinger, Robert C Grant, Reetesh K Pai, Stephen N Sinicrope, Dongyao Yan, Kandavel Shanmugam, James Conner, David P Cyr, Richard Kirsch, Imon Banerjee, Steve R Alberts, Qian Shi, Rish K Pai
Deep learning may detect biologically important signals embedded in tumor morphologic features that confer distinct prognoses. Tumor morphological features were quantified to enhance patient risk stratification within DNA mismatch repair (MMR) groups using deep learning. Using a quantitative segmentation algorithm (QuantCRC) that identifies 15 distinct morphological features, we analyzed 402 resected stage III colon carcinomas (191 d-MMR; 189 p-MMR) from participants in a phase III trial of FOLFOX-based adjuvant chemotherapy...
May 6, 2024: Cancer Res Commun