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tumor stroma ratio

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https://www.readbyqxmd.com/read/27895734/periostin-and-tumor-stroma-interactions-in-non-small-cell-lung-cancer
#1
Ulrich Nitsche, Daniela Stangel, Zheng Pan, Anna Melissa Schlitter, Irene Esposito, Ivonne Regel, Susanne Raulefs, Helmut Friess, Jörg Kleeff, Mert Erkan
Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-associated mortality globally. Interactions of the cancer cells with the tumor microenvironment are essential carcinogenic features for the majority of solid tumors, such as pancreatic cancer. The present study investigated the role of stromal activation in NSCLC and analyzed the surgical specimens of 93 patients by immunohistochemistry with regard to periostin (an extracellular matrix protein), α-smooth muscle actin (α-SMA; a marker of myofibroblasts) and cluster of differentiation 31 (CD31; a marker of endothelial cells), and the activated stroma index...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27864347/human-pancreatic-cancer-cells-induce-a-myd88-dependent-stromal-response-to-promote-a-tumor-tolerant-immune-microenvironment
#2
Daniel Delitto, Andrea E Delitto, Bayli B DiVita, Kien Pham, Song Han, Emily R Hartlage, Brittney N Newby, Michael H Gerber, Kevin E Behrns, Lyle L Moldawer, Ryan M Thomas, Thomas George, Todd Brusko, Clayton E Mathews, Chen Liu, Jose G Trevino, Steven J Hughes, Shannon Wallet
Cancer cells exert mastery over the local tumor-associated stroma (TAS) to configure protective immunity within the tumor microenvironment. The immunomodulatory character of pancreatic lysates of patients with cancer differs from those with pancreatitis. In this study, we evaluated the crosstalk between pancreatic cancer (PC) and its TAS in primary human cell culture models. Upon exposure of TAS to PC cell-conditioned media, we documented robust secretion of IL-6 and IL-8. This TAS response was MyD88-dependent and sufficient to directly suppress both CD4+ and CD8+ T cell proliferation, inducing Th17 polarization at the expense of Th1...
November 18, 2016: Cancer Research
https://www.readbyqxmd.com/read/27858181/intratumor-stromal-proportion-predicts-aggressive-phenotype-of-gastric-signet-ring-cell-carcinomas
#3
Dakeun Lee, In-Hye Ham, Sang Yong Son, Sang-Uk Han, Young-Bae Kim, Hoon Hur
OBJECTIVE: The aim of this study was to evaluate the prognostic significance of the intratumor stromal proportion in gastric signet ring cell (SRC) carcinomas. BACKGROUND: Cancer stroma, as exemplified by cancer-associated fibroblasts (CAFs), plays critical roles in cancer proliferation, invasion, and metastasis. METHODS: One hundred seventy-five SRC carcinoma cases were classified according to the intratumor desmoplastic stromal proportion to then analyze the clinicopathologic characteristics of stroma-rich cases...
November 17, 2016: Gastric Cancer
https://www.readbyqxmd.com/read/27851969/epigenomic-deconvolution-of-breast-tumors-reveals-metabolic-coupling-between-constituent-cell-types
#4
Vitor Onuchic, Ryan J Hartmaier, David N Boone, Michael L Samuels, Ronak Y Patel, Wendy M White, Vesna D Garovic, Steffi Oesterreich, Matt E Roth, Adrian V Lee, Aleksandar Milosavljevic
Cancer progression depends on both cell-intrinsic processes and interactions between different cell types. However, large-scale assessment of cell type composition and molecular profiles of individual cell types within tumors remains challenging. To address this, we developed epigenomic deconvolution (EDec), an in silico method that infers cell type composition of complex tissues as well as DNA methylation and gene transcription profiles of constituent cell types. By applying EDec to The Cancer Genome Atlas (TCGA) breast tumors, we detect changes in immune cell infiltration related to patient prognosis, and a striking change in stromal fibroblast-to-adipocyte ratio across breast cancer subtypes...
November 15, 2016: Cell Reports
https://www.readbyqxmd.com/read/27797069/igg4-related-sclerosing-mesenteritis-causing-bowel-obstruction-a-case-report
#5
Atsushi Abe, Tatsuya Manabe, Nobuyoshi Takizawa, Takashi Ueki, Daisuke Yamada, Kinuko Nagayoshi, Yoshihiko Sadakari, Hayato Fujita, Shuntaro Nagai, Hidetaka Yamamoto, Yoshinao Oda, Masafumi Nakamura
Sclerosing mesenteritis (SM) is a rare inflammatory and fibrosing disease primarily involving the small-bowel mesentery. Recently, SM was reported to be closely related to IgG4-related disease (IgG4-RD). This report describes a patient with SM associated with IgG4-RD. A 77-year-old woman with a history of surgery for ectopic pregnancy and wound dehiscence presented with intestinal obstruction. Abdominal enhanced computed tomography (CT) revealed an enhanced, radially shaped, oval mass, 3 cm in diameter, with an unclear rim in the mesentery of the distal ileum, which may have involved the distal ileum...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27792935/tissue-transglutaminase-activates-cancer-associated-fibroblasts-and-contributes-to-gemcitabine-resistance-in-pancreatic-cancer
#6
Jiyoon Lee, Bakhtiyor Yakubov, Cristina Ivan, David R Jones, Andrea Caperell-Grant, Melissa Fishel, Horacio Cardenas, Daniela Matei
Resistance to chemotherapy is a hallmark of pancreatic ductal adenocarcinoma (PDA) and has been partly attributed to the dense desmoplastic stroma, which forms a protective niche for cancer cells. Tissue transglutaminase (TG2), a Ca(2+)-dependent enzyme, is secreted by PDA cells and cross-links proteins in the tumor microenvironment (TME) through acyl-transfer between glutamine and lysine residues, promoting PDA growth. The objective of the current study was to determine whether secreted TG2 by PDA cells alters the response of pancreatic tumors to gemcitabine...
November 2016: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/27769871/re-evaluation-of-maml2-fusion-negative-mucoepidermoid-carcinoma-a-subgroup-being-actually-hyalinizing-clear-cell-carcinoma-of-the-salivary-gland-with-ewsr1-translocation
#7
Min-Shu Hsieh, Hsuang Wang, Yi-Hsuan Lee, Jenq-Yuh Ko, Yih-Leong Chang
Hyalinizing clear cell carcinoma (HCCC) is a rare salivary gland tumor with a specific EWSR1-ATF1 fusion gene and can have mucin production. Mucoepidermoid carcinoma (MEC) with a clear cell component is its morphologic mimic. Using MAML2 fluorescence in situ hybridization (FISH), a total of 49 MEC cases were separated into MAML2 fusion-positive (32 cases) and MAML2 fusion-negative groups (17 cases). This study used EWSR1 FISH to investigate MAML2 fusion-negative cases to identify previously unrecognized HCCC...
October 18, 2016: Human Pathology
https://www.readbyqxmd.com/read/27721275/evaluation-of-pathological-parameters-and-morphometric-data-of-desmoplastic-lobular-breast-carcinoma
#8
Ivan R Ilic, Nikola M Stojanović, Pavle J Randjelović, Marina N Mihajlović, Niko S Radulović, Ratko S Ilić
BACKGROUND: Invasive lobular breast cancer (ILC) is the second most frequent form of breast cancer. While cancer cells are regularly investigated, tumor stroma represents a highly unexplored field. AIMS: The aim of this study is to perform a detailed investigation of clinical, immunohistochemical, and morphometric characteristics of desmoplastic (D) and nondesmoplastic (ND) ILC. MATERIALS AND METHODS: This study included twenty cases of ILC that were divided into two groups designated as D and ND groups...
October 2016: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/27678304/breast-cancer-cell-invasion-into-a-three-dimensional-tumor-stroma-microenvironment
#9
Danh Truong, Julieann Puleo, Alison Llave, Ghassan Mouneimne, Roger D Kamm, Mehdi Nikkhah
In this study, to model 3D chemotactic tumor-stroma invasion in vitro, we developed an innovative microfluidic chip allowing side-by-side positioning of 3D hydrogel-based matrices. We were able to (1) create a dual matrix architecture that extended in a continuous manner, thus allowing invasion from one 3D matrix to another, and (2) establish distinct regions of tumor and stroma cell/ECM compositions, with a clearly demarcated tumor invasion front, thus allowing us to quantitatively analyze progression of cancer cells into the stroma at a tissue or single-cell level...
September 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27666630/soft-tissue-masses-with-myxoid-stroma-can-conventional-magnetic-resonance-imaging-differentiate-benign-from-malignant-tumors
#10
A Crombe, N Alberti, E Stoeckle, V Brouste, X Buy, J-M Coindre, M Kind
OBJECTIVES: To retrospectively evaluate the diagnostic performance of morphological signs observed on conventional magnetic resonance (MR) imaging to differentiate benign from malignant peripheral solid tumors of soft tissue with myxoid stroma. METHODS: MR images from 95 consecutive histopathologically proven tumors (26 benign and 69 malignant) of soft tissues with myxoid components were evaluated in our tertiary referral center. Two radiologists, blind to pathology results, independently reviewed conventional MR sequences including at least a) one T2-weighted sequence with or without fat suppression; b) one T1-weighted sequence without fat suppression; and c) one T1-weighted sequence with gadolinium-complex contrast enhancement and fat suppression...
October 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27661111/association-between-tumor-stroma-ratio-and-prognosis-in-solid-tumor-patients-a-systematic-review-and-meta-analysis
#11
Jiayuan Wu, Caixia Liang, Manyu Chen, Wenmei Su
Tumor-related stroma plays an active role in tumor invasion and metastasis. The tumor-stroma ratio (TSR) in the pathologic specimen has drawn increasing attention from the field of predicting tumor prognosis. However, the prognostic value of TSR in solid tumors necessitates further elucidation. We conducted a meta-analysis on 14 studies with 4238 patients through a comprehensive electronic search on databases updated on May 2016 to explore the relationship between TSR and prognosis of solid tumors. The overall hazard ratio showed that rich stroma in tumor tissue was associated with poor overall survival (OS) (14 studies, 4238 patients) and disease-free survival (DFS) (9 studies, 2235 patients) of patients with solid tumors...
September 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/27640003/the-ratio-of-cancer-cells-to-stroma-after-induction-therapy-in-the-treatment-of-non-small-cell-lung-cancer
#12
Masaki Goto, Masahito Naito, Koichi Saruwatari, Kakeru Hisakane, Motohiro Kojima, Satoshi Fujii, Takeshi Kuwata, Atsushi Ochiai, Shogo Nomura, Keiju Aokage, Tomoyuki Hishida, Junji Yoshida, Kohei Yokoi, Masahiro Tsuboi, Genichiro Ishii
PURPOSE: Induction therapy induces degenerative changes of various degrees in both cancerous and non-cancerous cells of non-small cell lung cancer (NSCLC). The effect of induction therapy on histological characteristics, in particular the ratio of residual cancer cells to non-cancerous components, is unknown. METHODS: Seventy-four NSCLC patients treated with induction therapy followed by surgery were enrolled. Residual cancer cells were identified using anti-pan-cytokeratin antibody (AE1/AE3)...
September 17, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27639626/determination-of-the-association-between-t2-weighted-mri-and-gleason-sub-pattern-a-proof-of-principle-study
#13
Michelle R Downes, Eli Gibson, Jenna Sykes, Masoom Haider, Theo H van der Kwast, Aaron Ward
RATIONALE AND OBJECTIVES: The study aimed to determine the relationship between T2-weighted magnetic resonance imaging (MRI) signal and histologic sub-patterns in prostate cancer areas with different Gleason grades. MATERIALS AND METHODS: MR images of prostates (n = 25) were obtained prior to radical prostatectomy. These were processed as whole-mount specimens with tumors and the peripheral zone was annotated digitally by two pathologists. Gleason grade 3 was the most prevalent grade and was subdivided into packed, intermediate, and sparse based on gland-to-stroma ratio...
September 14, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27616660/tumor-stroma-containing-3d-spheroid-arrays-a-tool-to-study-nanoparticle-penetration
#14
Dwi L Priwitaningrum, Jean-Baptiste G Blondé, Adithya Sridhar, Joop van Baarlen, Wim E Hennink, Gert Storm, Séverine Le Gac, Jai Prakash
Nanoparticle penetration through tumor tissue after extravasation is considered as a key issue for tumor distribution and therapeutic effects. Most tumors possess abundant stroma, a fibrotic tissue composed of cancer-associated fibroblasts (CAFs) and extracellular matrix (ECM), which acts as a barrier for nanoparticle penetration. There is however a lack of suitable in vitro systems to study the tumor stroma penetration of nanoparticles. In the present study, we developed and thoroughly characterized a 3D co-culture spheroidal array to mimic tumor stroma and investigated the penetration of silica and PLGA nanoparticles in these spheroids...
September 9, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27613548/are-disseminated-tumor-cells-in-bone-marrow-and-tumor-stroma-ratio-clinically-applicable-for-patients-undergoing-surgical-resection-of-primary-colorectal-cancer-the-leiden-mrd-study
#15
F J Vogelaar, G W van Pelt, A M van Leeuwen, J M Willems, R A E M Tollenaar, G J Liefers, W E Mesker
PURPOSE: Current TNM staging does not appropriately identify high-risk colorectal cancer (CRC) patients. The aim of this study was to evaluate whether the presence of disseminated tumor cells (DTCs) in the bone marrow (BM) and the presence of stroma in the primary tumor, i.e., the tumor-stroma ratio (TSR), in patients undergoing surgical resection of primary CRC provides information relevant for disease outcome. METHODS: Patients with primary CRC (n = 125), consecutively admitted for curative resection between 2001 and 2007, were included in the study...
September 9, 2016: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/27601919/an-isolated-orbital-mass-with-proptosis-and-diplopia-an-uncommon-metastasis-from-intracranial-olfactory-neuroblastoma-in-a-chinese-patient
#16
Jianqin Shen, Hongguang Cui, Shi Feng
PURPOSE: Olfactory neuroblastoma (ONB) is a rare neuroectodermal malignant neoplasm that originates from the olfactory sensory epithelium. In reported cases involving the orbit, the primary neoplasms could invade the orbits through bone destruction or cranio-orbital communication anatomical structure. The present study reports a rare case of orbital metastatic tumor arising from an intracranial ONB in a Chinese patient, which is the first case demonstrating an uncommon route of ONB involving the orbit...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27549930/3d-microtumors-in-vitro-supported-by-perfused-vascular-networks
#17
Agua Sobrino, Duc T T Phan, Rupsa Datta, Xiaolin Wang, Stephanie J Hachey, Mónica Romero-López, Enrico Gratton, Abraham P Lee, Steven C George, Christopher C W Hughes
There is a growing interest in developing microphysiological systems that can be used to model both normal and pathological human organs in vitro. This "organs-on-chips" approach aims to capture key structural and physiological characteristics of the target tissue. Here we describe in vitro vascularized microtumors (VMTs). This "tumor-on-a-chip" platform incorporates human tumor and stromal cells that grow in a 3D extracellular matrix and that depend for survival on nutrient delivery through living, perfused microvessels...
August 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27493080/cytomorphology-and-clinicopathologic-correlation-of-the-recurrent-and-metastatic-adult-granulosa-cell-tumor-of-the-ovary-a-retrospective-review
#18
Aparna Harbhajanka, Pincas Bitterman, Vijaya B Reddy, Ji-Weon Park, Paolo Gattuso
Granulosa cell tumors (GCT) of the ovary are low grade tumor with a potential ability of late pelvic recurrences and distant metastases. However, there is sparse literature on the cytopathologic features of metastatic granulosa cell tumors (MGCT). Between 2000 and 2014, eight cases of MGCT were diagnosed by FNA. Clinical, cytologic, and histopathologic features were reviewed. The age ranged from 34 to 84 years. Metastases were found in abdominal wall (4 cases), pelvic mass (1 case), liver (2 cases), and lung (1 case)...
December 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27472713/elevated-expression-of-growth-regulated-oncogene-alpha-in-tumor-and-stromal-cells-predicts-unfavorable-prognosis-in-pancreatic-cancer
#19
Shuijin Lian, Xiaolu Zhai, Xudong Wang, Huijun Zhu, Shu Zhang, Wei Wang, Zhiwei Wang, Jianfei Huang
Growth-regulated oncogene-alpha (GRO-α) has been reported to be over-expressed in a series of human cancers including colorectal cancer, melanoma, gastric cancer, hepatocellular carcinoma, and ovarian cancer and was known to regulate multiple biologic activities associated with tumor progression. But the role in human pancreatic cancer remains unclear. To examine the expression of GRO-α and its clinical significance in pancreatic cancer (PC), a total of 12 fresh PC specimens and 12 surrounding normal tissues to detect GRO-α mRNA expression were measured by quantitative real-time polymerase chain reaction (qRT-PCR)...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27454486/blood-based-biomarkers-are-associated-with-disease-recurrence-and-survival-in-gastrointestinal-stroma-tumor-patients-after-surgical-resection
#20
Michael Stotz, Bernadette Liegl-Atzwanger, Florian Posch, Edvin Mrsic, Michael Thalhammer, Tatjana Stojakovic, Angelika Bezan, Martin Pichler, Armin Gerger, Joanna Szkandera
BACKGROUND: Inflammatory blood count biomarkers may improve recurrence risk stratification and inform long-term prognosis of cancer patients. Here, we quantify the prognostic impact of blood-based biomarkers on recurrence risk and long-term survival in a large cohort of gastrointestinal stroma tumor (GIST) patients after curative surgery. METHODS: One-hundred-forty-nine consecutive GIST patients were followed-up for a median period of 4.8 years. Local recurrence, distant metastasis, and death occurred in 9, 21, and 31 patients, respectively...
2016: PloS One
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