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tumor stroma ratio

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https://www.readbyqxmd.com/read/29471527/the-heterogeneity-between-lynch-associated-and-sporadic-mmr-deficiency-in-colorectal-cancers
#1
Guo-Chen Liu, Ran-Yi Liu, Jun-Ping Yan, Xin An, Wu Jiang, Yi-Hong Ling, Jie-Wei Chen, Jin-Xin Bei, Xiao-Yu Zuo, Mu-Yan Cai, Ze-Xian Liu, Zhi-Xiang Zuo, Ji-Hong Liu, Zhi-Zhong Pan, Pei-Rong Ding
Background: Previous studies demonstrated that prognosis of germline deficiency in mismatch repair protein (dMMR) was different from that of sporadic dMMR. The underlying mechanism has not been studied. Methods: From a prospectively maintained database, we collected dMMR colorectal cancer (CRC) patients identified by postoperative immunohistochemistry screening. According to genetic test, patients were grouped as Lynch-associated or sporadic dMMR. We compared the clinical-pathological features, prognosis, and immunoreactive differences between the two groups...
February 20, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29467127/quantitative-analysis-of-immune-infiltrates-in-primary-melanoma
#2
Robyn D Gartrell, Douglas K Marks, Thomas D Hart, Gen Li, Danielle R Davari, Alan Wu, Zoe Blake, Yan Lu, Kayleigh N Askin, Anthea Monod, Camden L Esancy, Edward C Stack, Dan Tong Jia, Paul M Armenta, Yichun Fu, Daisuke Izaki, Bret Taback, Raul Rabadan, Howard L Kaufman, Charles G Drake, Basil A Horst, Yvonne M Saenger
Novel methods to analyze the tumor microenvironment (TME) are urgently needed to stratify melanoma patients for adjuvant immunotherapy. Tumor infiltrating lymphocyte (TIL) analysis, by conventional pathologic methods, is predictive but is insufficiently precise for clinical application. Quantitative multiplex immunofluorescence (qmIF), allows for evaluation of the TME using multiparameter phenotyping, tissue segmentation, and quantitative spatial analysis (qSA). Given that CD3+CD8+ cytotoxic lymphocytes (CTLs) promote antitumor immunity, whereas CD68+ macrophages impair immunity, we hypothesized that quantification and spatial analysis of macrophages and CTLs would correlate with clinical outcome...
February 21, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29448309/the-value-of-additional-bevacizumab-in-patients-with-high-risk-stroma-high-colon-cancer-a-study-within-the-quasar2-trial-an-open-label-randomized-phase-3-trial
#3
Anouck Huijbers, Gabi W van Pelt, Rachel S Kerr, Elaine C Johnstone, Rob A E M Tollenaar, David J Kerr, Wilma E Mesker
INTRODUCTION: Patients with a high stroma percentage within the primary tumor have a poor prognosis. In this study, we investigate whether anti-angiogenic therapy might improve survival of patients with a stroma-high profile with potentially increased angiogenesis. MATERIALS AND METHODS: Tissue samples of the primary tumor of 965 colon cancer patients participating in the QUASAR2 trial were analyzed for tumor-stroma ratio (TSR). Stroma-high (>50%) and stroma-low (≤50%) groups were evaluated with respect to survival...
February 15, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29435735/immunosuppressive-tumor-microenvironment-of-usual-interstitial-pneumonia-associated-squamous-cell-carcinoma-of-the-lung
#4
Takuya Ueda, Keiju Aokage, Hiroyoshi Nishikawa, Shinya Neri, Hiroshi Nakamura, Masato Sugano, Kenta Tane, Tomohiro Miyoshi, Motohiro Kojima, Satoshi Fujii, Takeshi Kuwata, Atsushi Ochiai, Masahiko Kusumoto, Kenji Suzuki, Masahiro Tsuboi, Genichiro Ishii
PURPOSE: Patients with usual interstitial pneumonia (UIP) often develop lung cancer. However, the biological features of lung cancer associated with UIP remain unknown. The aim of this study was to elucidate the clinicopathological characteristics of UIP-associated squamous cell carcinoma (SqCC). METHODS: A total of 244 patients with p-stage I lung SqCC who underwent complete surgical resection were enrolled in this study. Clinicopathological differences between UIP-associated SqCC and non-UIP SqCC were examined...
February 12, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29427291/prognostic-impact-of-tumour-stroma-ratio-in-early-stage-oral-tongue-cancers
#5
Alhadi Almangush, Ilkka Heikkinen, Nassira Bakhti, Laura K Mäkinen, Joonas H Kauppila, Matti Pukkila, Jaana Hagström, Jussi Laranne, Ylermi Soini, Luiz Paulo Kowalski, Reidar Grénman, Caj Haglund, Antti A Mäkitie, Ricardo D Coletta, Ilmo Leivo, Tuula Salo
AIMS: Oral tongue squamous cell carcinoma (OTSCC) has a relatively poor outcome and there is a need to identify better prognostic factors. Recently, tumour-stroma ratio (TSR) has been associated with prognosis in several cancers. This multi-institutional study evaluates the prognostic value of TSR from original HE-stained tumor-resection slides in a series of early-stage (cT1-2N0) OTSCC patients. METHODS AND RESULTS: A TSR cutoff value of 50% was used to divide the patients into stroma-rich (≥50%) and stroma-poor (<50%) groups...
February 10, 2018: Histopathology
https://www.readbyqxmd.com/read/29383131/development-of-a-reliable-and-accurate-algorithm-to-quantify-the-tumor-immune-stroma-qtis-across-tumor-types
#6
Rainer Christoph Miksch, Jingcheng Hao, Markus Bo Schoenberg, Katharina Dötzer, Friederike Schlüter, Maximilian Weniger, Shuai Yin, Steffen Ormanns, Jan Goesta D'Haese, Markus Otto Guba, Jens Werner, Barbara Mayer, Alexandr V Bazhin
The tumor microenvironment plays an important role in the tumor biology. Overall survival of tumor patients after resection is influenced by tumor-infiltrating lymphocytes (TILs) as a component of the tumor stroma. However, it is not clear how to assess TILs in the tumor stroma due to heterogeneous methods in different cancer types. Therefore, we present a novel Quantification of the Tumor immune Stroma (QTiS) Algorithm to reliably and accurately quantify cells in the tumor stroma. Immunohistochemical staining of CD3 and CD8 cells in sections of metastatic colorectal cancer (mCRC), ovarian cancer (OvCa), hepatocellular carcinoma (HCC), and pancreatic ductal adenocarcinoma (PDAC), alltogether N = 80, was performed...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29359949/comparison-of-peritumoral-stromal-tissue-stiffness-obtained-by-shear-wave-elastography-between-benign-and-malignant-breast-lesions
#7
Hye Sun Park, Hee Jung Shin, Ki Chang Shin, Joo Hee Cha, Eun Young Chae, Woo Jung Choi, Hak Hee Kim
Background Aggressive breast cancers produce abnormal peritumoral stiff areas, which can differ between benign and malignant lesions and between different subtypes of breast cancer. Purpose To compare the tissue stiffness of the inner tumor, tumor border, and peritumoral stroma (PS) between benign and malignant breast masses by shear wave elastography (SWE). Material and Methods We enrolled 133 consecutive patients who underwent preoperative SWE. Using OsiriX commercial software, we generated multiple 2-mm regions of interest (ROIs) in a linear arrangement on the inner tumor, tumor border, and PS...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29326439/lung-fibroblasts-promote-metastatic-colonization-through-upregulation-of-stearoyl-coa-desaturase-1-in-tumor-cells
#8
Guanghua Liu, Shi Feng, Lin Jia, Chunying Wang, Yan Fu, Yongzhang Luo
As a rate-limiting step in metastasis, metastatic colonization requires survival signals from supportive stroma. However, the mechanisms driving this process are incompletely understood. Here, we showed that the proliferation of B16F10 cells was promoted when cocultured with lung fibroblasts. Meanwhile, co-injection of B16F10 tumor cells with mouse lung fibroblasts significantly increased lung metastasis. Based on GEO database, we identified stearoyl-CoA desaturase 1 (SCD1) as a novel factor promoting metastatic colonization...
January 12, 2018: Oncogene
https://www.readbyqxmd.com/read/29296631/features-of-mri-stromal-enhancement-with-neoadjuvant-chemotherapy-a-subgroup-analysis-of-the-acrin-6657-i-spy-trial
#9
Adam Olshen, Denise Wolf, Ella F Jones, David Newitt, Laura van 't Veer, Christina Yau, Laura Esserman, Julia D Wulfkuhle, Rosa I Gallagher, Lisa Singer, Emanuel F Petricoin, Nola Hylton, Catherine C Park
Although the role of cancer-activated stroma in malignant progression has been well investigated, the influence of an activated stroma in therapy response is not well understood. Using retrospective pilot cohorts, we previously observed that MRI detected stromal contrast enhancement was associated with proximity to the tumor and was predictive for relapse-free survival in patients with breast cancer receiving neoadjuvant chemotherapy. Here, to evaluate the association of stromal contrast enhancement to therapy, we applied an advanced tissue mapping technique to evaluate stromal enhancement patterns within 71 patients enrolled in the I-SPY 1 neoadjuvant breast cancer trial...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29290917/tumor-stroma-ratio-as-prognostic-factor-for-survival-in-rectal-adenocarcinoma-a-retrospective-cohort-study
#10
René Scheer, Alexi Baidoshvili, Shorena Zoidze, Marloes A G Elferink, Annefleur E M Berkel, Joost M Klaase, Paul J van Diest
AIM: To evaluate the prognostic value of the tumor-stroma ratio (TSR) in rectal cancer. METHODS: TSR was determined on hematoxylin and eosin stained histological sections of 154 patients treated for rectal adenocarcinoma without prior neoadjuvant treatment in the period 1996-2006 by two observers to assess reproducibility. Patients were categorized into three categories: TSR-high [carcinoma percentage (CP) ≥ 70%], TSR-intermediate (CP 40%, 50% and 60%) and TSR-low (CP ≤ 30%)...
December 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29273955/prognostic-value-of-tumor-stroma-ratio-combined-with-the-immune-status-of-tumors-in-invasive-breast-carcinoma
#11
K M H Vangangelt, G W van Pelt, C C Engels, H Putter, G J Liefers, V T H B M Smit, R A E M Tollenaar, P J K Kuppen, W E Mesker
PURPOSE: Complex interactions occur between cancer cells and cells in the tumor microenvironment. In this study, the prognostic value of the interplay between tumor-stroma ratio (TSR) and the immune status of tumors in breast cancer patients was evaluated. METHODS: A cohort of 574 breast cancer patients was analyzed. The percentage of tumor stroma was visually estimated on Hematoxylin and Eosin (H&E) stained histological tumor tissue sections. Immunohistochemical staining was performed for classical human leukocyte antigen (HLA) class I, HLA-E, HLA-G, markers for regulatory T (Treg) cells, natural killer (NK) cells and cytotoxic T-lymphocytes (CTLs)...
December 22, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29237913/the-clinical-significance-of-secreted-protein-acidic-and-rich-in-cysteine-expression-in-breast-cancer-tissue-and-its-association-with-prognosis
#12
Wei Guo, Mingliang Zhang, Yong Chen, Suyang Guo
OBJECTIVE: The aim of this study was to evaluate the secreted protein acidic and rich in cysteine (SPARC) expression in breast cancer tissue and its association with patients' clinical pathology characteristics and prognosis. MATERIALS AND METHODS: Eight-eight cases with confirmed diagnosis of breast cancer who received operation from January 2010 to February 2016 were included in this study. The SPARC expression in cancer tissue was examined by immunohistochemical method...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29222676/intravoxel-incoherent-motion-mr-imaging-of-early-cervical-carcinoma-correlation-between-imaging-parameters-and-tumor-stroma-ratio
#13
Xiangsheng Li, Ping Wang, Dechang Li, Hongxian Zhu, Limin Meng, Yunlong Song, Lizhi Xie, Jianping Zhu, Tao Yu
OBJECTIVES: To investigate if intravoxel incoherent motion (IVIM) MR imaging can predict the tumour-stroma ratio (TSR) in patients with early cervical carcinoma. METHODS: Fifty-four patients with early cervical carcinoma were prospectively enrolled into this study. All patients underwent IVIM imaging and parameters including D, D* and f value were measured. The tumours were classified into stroma-rich and stroma-poor group according to TSR, and comparisons of IVIM parameters between two groups were performed...
December 8, 2017: European Radiology
https://www.readbyqxmd.com/read/29184132/circulating-complement-component-4d-c4d-correlates-with-tumor-volume-chemotherapeutic-response-and-survival-in-patients-with-malignant-pleural-mesothelioma
#14
Thomas Klikovits, Paul Stockhammer, Viktoria Laszlo, Yawen Dong, Mir Alireza Hoda, Bahil Ghanim, Isabelle Opitz, Thomas Frauenfelder, Thi Dan Linh Nguyen-Kim, Walter Weder, Walter Berger, Michael Grusch, Clemens Aigner, Walter Klepetko, Balazs Dome, Ferenc Renyi-Vamos, Rudolf Oehler, Balazs Hegedus
Only limited information is available on the role of complement activation in malignant pleural mesothelioma (MPM). Thus, we investigated the circulating and tissue levels of the complement component 4d (C4d) in MPM. Plasma samples from 55 MPM patients, 21 healthy volunteers (HV) and 14 patients with non-malignant pleural diseases (NMPD) were measured by ELISA for C4d levels. Tissue specimens from 32 patients were analyzed by C4d immunohistochemistry. Tumor volumetry was measured in 20 patients. We found no C4d labeling on tumor cells, but on ectopic lymphoid structures within the tumor stroma...
November 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29151905/stromal-and-intraepithelial-tumor-infiltrating-lymphocytes-in-colorectal-carcinoma
#15
Katarzyna Jakubowska, Wojciech Kisielewski, Luiza Kańczuga-Koda, Mariusz Koda, Waldemar Famulski
The local mechanisms of antitumor immune defense determine the development and organization of the tumor microenvironment, and the composition and relative proportions of the inflammatory cell population affect the quality and characteristics of the immune response. The aim of the present study was to conduct a quantitative morphological evaluation of two types of tumor-infiltrating lymphocyte (TILs) populations, including those located in the stroma and intraepithelial cancer structures, in the invasive front and the center of the tumor in patients with colorectal cancer (CRC)...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29108360/prediction-of-radio-responsiveness-with-immune-profiling-in-patients-with-rectal-cancer
#16
In Ja Park, Soyeon An, Sang-Yeob Kim, Hye Min Lim, Seung-Mo Hong, Mi-Ju Kim, Yun Jae Kim, Chang Sik Yu
We evaluate whether the tumor immune infiltrate (TIL) could be used for prediction of responsiveness to preoperative chemoradiotherapy (PCRT) in rectal cancers. Using formalin-fixed paraffin-embedded slides of pretreatment biopsies, co-stain for CD4, CD8, CD274 (PD-L1), FOXP3, cytokeratin, and DAPI was performed with Opal multi staining kit (Perkin-Elmer, Waltham, MA). Multispectral imaging and digital analysis to visualize and quantify specific immune infiltrates were performed using the Vectra imaging system (Perkin-Elmer)...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29064053/correlation-of-circulating-cd64-cd163-monocyte-ratio-and-stroma-peri-tumoral-cd163-monocyte-density-with-human-papillomavirus-infected-cervical-lesion-severity
#17
Piyawut Swangphon, Chamsai Pientong, Nuchsupha Sunthamala, Sureewan Bumrungthai, Miyuki Azuma, Pilaiwan Kleebkaow, Thumwadee Tangsiriwatthana, Ussanee Sangkomkamhang, Bunkerd Kongyingyoes, Tipaya Ekalaksananan
HPV infected cervical cells secrete mediators that are gradually changed and have influence on infiltrating M2 phenotypic monocytes in cervical lesions. However, profiles of circulating immune cells in women with cervical lesions and M2 phenotypic monocyte activity in HPV infected cervical lesions are limited. This study aimed to investigate circulating monocyte populations correlated with M2 phenotype density and its activity in HPV infected cervical lesions. HPV DNA was investigated in cervical tissues using PCR...
October 24, 2017: Cancer Microenvironment: Official Journal of the International Cancer Microenvironment Society
https://www.readbyqxmd.com/read/29053481/programmed-death-ligand-1-expression-among-700-consecutive-endometrial-cancers-strong-association-with-mismatch-repair-protein-deficiency
#18
Zaibo Li, Amy S Joehlin-Price, Jennifer Rhoades, Martins Ayoola-Adeola, Karin Miller, Anil V Parwani, Floor J Backes, Ashley S Felix, Adrian A Suarez
OBJECTIVE: This study aims to determine the prevalence of programmed death ligand 1 (PD-L1) expression in endometrial carcinoma (EC) and determine clinical and pathological associations. METHODS: Immunohistochemistry for PD-L1 was performed on sections of a triple-core tissue microarray of 700 ECs. Positive PD-L1 expression, defined as 1% of cells staining positive, was evaluated in tumor and stromal compartments. Using age-adjusted logistic regression, we estimated odds ratios and 95% confidence intervals for associations between PD-L1 expression (overall and by staining compartment) with clinical and tumor characteristics...
October 20, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29043992/correlation-of-the-ultrasound-imaging-of-breast-cancer-and-the-expression-of-molecular-biological-indexes
#19
Jie Xu, Feng Li, Fengling Chang
This paper aims to 137 cases of breast malignant tumors confirmed by surgery and pathology were collected. All patients received ultrasound examination and were not treated by radiotherapy or chemotherapy before operation. The preoperative ultrasound images of breast cancer patients and postoperative pathological characteristics of paraffin sections were retrospectively observed. Ultrasound indicators included tumor size, shape, ratio of the longest/shortest dimension, edge of the spiculation and peripheral hyperechoic halo sign, internal echo types, micro calcification, posterior echo types, blood flow and signs of lymph node metastasis...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29025374/the-prognostic-significance-of-cancer-associated-fibroblasts-in-pancreatic-ductal-adenocarcinoma
#20
Hyunjin Park, Yangkyu Lee, Hyejung Lee, Jin-Won Kim, Jin-Hyeok Hwang, Jaihwan Kim, Yoo-Seok Yoon, Ho-Seong Han, Haeryoung Kim
Cancer-associated fibroblasts are abundant in the desmoplastic stroma of pancreatic ductal adenocarcinomas and are considered to play important roles in tumor progression. In this study, we investigated the expression status of secreted protein acidic and rich in cysteine, periostin, fibroblast-activated protein, and the newly developed proCOL11A1 antibody in the stroma of surgically resected pancreatic ductal adenocarcinomas and their prognostic implications. Tissue microarrays were constructed from 155 surgically resected pancreatic ductal adenocarcinomas and paired non-neoplastic pancreata and from another independent set of 48 normal/benign pancreata, and immunohistochemical stains were performed for proCOL11A1, fibroblast-activated protein, secreted protein acidic and rich in cysteine, and periostin...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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