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tumor stroma ratio

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https://www.readbyqxmd.com/read/28427165/prognostic-significance-of-tumor-associated-macrophages-in-breast-cancer-a-meta-analysis-of-the-literature
#1
REVIEW
Xixi Zhao, Jingkun Qu, Yuchen Sun, Jizhao Wang, Xu Liu, Feidi Wang, Hong Zhang, Wen Wang, Xingcong Ma, Xiaoyan Gao, Shuqun Zhang
PURPOSE: Tumor associated macrophages (TAMs) are important prognostic factors and have been proved to be associated with the invasion and migration of various cancer. However, the relationship between TAMs and breast cancer outcomes remains unclear. EXPERIMENTAL DESIGN: Sixteen studies with a total of 4,541 breast cancer patients were included in this meta-analysis. Correlation of TAMs with overall survival (OS), disease-free survival(DFS), relapse-free survival (RFS), breast cancer special survival (BCSS) and clinicopathological features were analyzed...
February 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28388691/expression-and-prognostic-significance-of-myl9-in-esophageal-squamous-cell-carcinoma
#2
Jian-Hua Wang, Lan Zhang, Shu-Ting Huang, Jing Xu, Yun Zhou, Xing-Juan Yu, Rong-Zhen Luo, Zhe-Sheng Wen, Wei-Hua Jia, Min Zheng
OBJECTIVE: Myosin light chain 9 (MYL9) is necessary for cytoskeletal dynamics and experimental metastasis, but its expression in esophageal squamous cell carcinoma (ESCC) has not been addressed. We investigated the expression pattern and clinical significance of MYL9 in patients with ESCC. METHODS: We examined MYL9 expression using quantitative real-time PCR and western blotting in NE1 immortalized esophageal epithelial cells, ESCC cell lines, and paired ESCC tissues...
2017: PloS One
https://www.readbyqxmd.com/read/28315927/hla-dr-expression-in-tumor-epithelium-is-an-independent-prognostic-indicator-in-esophageal-adenocarcinoma-patients
#3
Margaret R Dunne, Adriana J Michielsen, Katie E O'Sullivan, Mary Clare Cathcart, Ronan Feighery, Brendan Doyle, Jenny A Watson, Naoimh J O'Farrell, Narayanasamy Ravi, Elaine Kay, John V Reynolds, Elizabeth J Ryan, Jacintha O'Sullivan
Esophageal adenocarcinoma (EAC) is an aggressive cancer with poor prognosis, and incidence is increasing rapidly in the Western world. Measurement of immune markers has been shown to have prognostic significance in a growing number of cancers, but whether this is true for EAC has yet to be evaluated. This study aimed to characterize HLA-DR expression in the esophagus across the inflammation to cancer progression sequence and to assess the prognostic significance of HLA-DR expression in EAC. Tissue microarrays (TMA) were constructed from esophageal tissue taken from patients at different stages in the cancer progression sequence; normal, esophagitis, Barrett's esophagus (BE), low- and high-grade dysplasia (LGD, HGD) and EAC...
March 18, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28246206/a-phase-ii-randomized-double-blind-placebo-controlled-study-of-simtuzumab-or-placebo-in-combination-with-gemcitabine-for-the-first-line-treatment-of-pancreatic-adenocarcinoma
#4
Al B Benson, Zev A Wainberg, J Randolph Hecht, Dmitry Vyushkov, Hua Dong, Johanna Bendell, Fred Kudrik
LESSONS LEARNED: The safety profile in the gemcitabine/simtuzumab group was similar to that in the gemcitabine/placebo group.The addition of simtuzumab to gemcitabine does not improve clinical outcomes in patients with metastatic pancreatic adenocarcinoma BACKGROUND: The humanized IgG4 monoclonal antibody simtuzumab inhibits the extracellular matrix-remodeling enzyme lysyl oxidase-like 2 maintaining pathological stroma in tumors. METHODS: Adult patients with metastatic pancreatic adenocarcinoma (mPaCa) were randomly assigned to receive intravenous gemcitabine, 1,000 mg/m(2), in combination with 200 or 700 mg simtuzumab or placebo...
February 28, 2017: Oncologist
https://www.readbyqxmd.com/read/28239052/an-atypical-case-of-recurrent-carotid-body-carcinoma-in-a-young-adult-dog-histopathological-immunohistochemical-and-electron-microscopic-study
#5
Angeline Ping Ping Teh, Watanyoo Pratakpiriya, Yuichi Hidaka, Hiroyuki Sato, Takuya Hirai, Ryoji Yamaguchi
A 3.5-year-old female Chihuahua was presented with complaint of neck pain, intermittent cough and dysphagia. Physical examination and diagnostic imaging of neck region revealed a solid and highly vascularized mass involving the retropharyngeal region. Histologically, the mass showed an atypical zellballen pattern which comprised of high density of type I chief cells with high nuclear cytoplasmic ratio and separated by delicate fibrovascular stroma. Immunoreactivity for neuroendocrine markers was diffusely positive in cytoplasm of tumor cells...
February 27, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28197375/tumor-infiltrating-lymphocyte-composition-organization-and-pd-1-pd-l1-expression-are-linked-in-breast-cancer
#6
Laurence Buisseret, Soizic Garaud, Alexandre de Wind, Gert Van den Eynden, Anais Boisson, Cinzia Solinas, Chunyan Gu-Trantien, Céline Naveaux, Jean-Nicolas Lodewyckx, Hugues Duvillier, Ligia Craciun, Isabelle Veys, Denis Larsimont, Martine Piccart-Gebhart, John Stagg, Christos Sotiriou, Karen Willard-Gallo
The clinical relevance of tumor-infiltrating lymphocytes (TIL) in breast cancer (BC) has been clearly established by their demonstrated correlation with long-term positive outcomes. Nevertheless, the relationship between protective immunity, observed in some patients, and critical features of the infiltrate remains unresolved. This study examined TIL density, composition and organization together with PD-1 and PD-L1 expression in freshly collected and paraffin-embedded tissues from 125 patients with invasive primary BC...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28197370/infiltration-of-pd-1-positive-cells-in-combination-with-tumor-site-pd-l1-expression-is-a-positive-prognostic-factor-in-cutaneous-angiosarcoma
#7
Yuki Honda, Atsushi Otsuka, Sachiko Ono, Yosuke Yamamoto, Judith A Seidel, Satoshi Morita, Masahiro Hirata, Tatsuki R Kataoka, Tatsuya Takenouchi, Kazuyasu Fujii, Takuro Kanekura, Yuko Okubo, Kenzo Takahashi, Teruki Yanagi, Daichi Hoshina, Hiroo Hata, Riichiro Abe, Taku Fujimura, Takeru Funakoshi, Koji Yoshino, Mamiko Masuzawa, Yasuyuki Amoh, Ryota Tanaka, Yasuhiro Fujisawa, Tetsuya Honda, Kenji Kabashima
Cutaneous angiosarcoma (CAS) is a malignant sarcoma with poor prognosis. Programmed cell death-1 (PD-1)/programmed cell death-1 ligand-1 (PD-L1) expression reflects antitumor immunity, and is associated with patient prognosis in various cancers. The purpose of this study is to investigate the relationship between PD-1/PD-L1 expression and CAS prognosis. CAS cases (n = 106) were immunohistochemically studied for PD-L1 and PD-1 expression, and the correlation with patient prognosis was analyzed. PD-L1 expression was assessed by flow cytometry on three CAS cell lines with or without IFNγ stimulation...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28187033/prognostic-significance-of-stromal-versus-intratumoral-infiltrating-lymphocytes-in-different-subtypes-of-breast-cancer-treated-with-cytotoxic-neoadjuvant-chemotherapy
#8
Thaer Khoury, Vidya Nagrale, Mateusz Opyrchal, Xuan Peng, Dan Wang, Song Yao
BACKGROUND: The aim of the study was to investigate if there were differences in associations of stromal versus intratumoral tumor infiltrating lymphocytes (TILs) with pathology complete response (pCR) among breast cancer (BC) subtypes treated with neoadjuvant therapy. MATERIALS AND METHODS: The hematoxylin and eosin slides of BC-core biopsy consecutive cases (n=331) were reviewed from a single institution between 2000 and 2014. TIL-stroma (TIL-str) was scored from 0% to 100%...
February 9, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28031106/-protective-effect-of-human-amnion-epithelial-cells-through-endotracheal-instillation-against-lipopolysaccharide-induced-acute-lung-injury-in-mice
#9
Yanmin Xia, Wenchen Wang, Hong Zhang, Jiakuan Chen, Ming Wang, Zhonghu Ge, Jian Wang, Tao Jiang
Objective To investigate the therapeutic effect of human amnion epithelial cells (hAECs) through endotracheal instillation on acute lung injury (ALI) induced by lipopolysaccharide (LPS) in mice and its underlying mechanism. Methods Male C57BL/6 mice were randomly divided into normal control group, hAECs control group, LPS-induced ALI group and hAECs treatment group (n=10 each group). In the latter two groups, mice were subjected to LPS (5 mg/kg) by oral insertion, and 1 hour later, PBS (50 μL) and hAECs (1×10(7)/mL, 50 μL) were administered by oral insertion in the two groups, respectively...
January 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28011489/prognostic-impact-of-cd163-macrophages-in-tumor-stroma-and-cd8-t-cells-in-cancer-cell-nests-in-invasive-extrahepatic-bile-duct-cancer
#10
Takuya Miura, Tadashi Yoshizawa, Hideaki Hirai, Hiroko Seino, Satoko Morohashi, Yunyan Wu, Taiichi Wakiya, Norihisa Kimura, Daisuke Kudo, Keinosuke Ishido, Yoshikazu Toyoki, Hiroshi Kijima, Kenichi Hakamada
AIM: The aim of this study was to examine the clinicopathological influence of tumor-infiltrating cluster of differentiation (CD) 163(+) macrophages and CD8(+) T-cells, and to clarify the prognostic effects of these cells in patients with invasive extrahepatic bile duct cancer (EHBC). MATERIALS AND METHODS: The numbers of CD8(+) T-cells in cancer cell nests and CD163(+) macrophages in tumor stroma were evaluated using immunohistochemistry in 101 resected EHBC specimens...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28007509/keratoameloblastoma-of-the-mandible
#11
S Anajar, A Lakhbal, R Abada, M Mahtar
INTRODUCTION: Keratoameloblastoma is an extremely rare odontogenic tumor, as only 18 cases have been reported in the literature. CASE REPORT: The authors report a case of keratoameloblastoma in a 32-year-old woman and review the literature concerning the clinical features, radiological appearance, histopathological findings and treatment options. DISCUSSION: Keratoameloblastoma is a rare tumor observed more frequently in males (sex ratio: 3:1) characterized by extensive keratin production in odontogenic islets and fibrous stroma...
December 19, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/27923328/modeling-stroma-induced-drug-resistance-in-a-tissue-engineered-tumor-model-of-ewing-sarcoma
#12
Marco Santoro, Brian A Menegaz, Salah-Eddine Lamhamedi-Cherradi, Eric R Molina, Danielle Wu, Waldemar Priebe, Joseph A Ludwig, Antonios G Mikos
Three-dimensional (3D) tumor models are gaining traction in the research community given their capacity to mimic aspects of the tumor microenvironment absent in monolayer systems. In particular, the ability to spatiotemporally control cell placement within ex vivo 3D systems has enabled the study of tumor-stroma interactions. Furthermore, by regulating biomechanical stimuli, one can reveal how biophysical cues affect stromal cell phenotype and how their phenotype impacts tumor drug sensitivity. Both tumor architecture and shear force have profound effects on Ewing sarcoma (ES) cell behavior and are known to elicit ligand-mediated activation of the insulin-like growth factor-1 receptor (IGF-1R), thereby mediating resistance of ES cells to IGF-1R inhibitors...
January 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27895734/periostin-and-tumor-stroma-interactions-in-non-small-cell-lung-cancer
#13
Ulrich Nitsche, Daniela Stangel, Zheng Pan, Anna Melissa Schlitter, Irene Esposito, Ivonne Regel, Susanne Raulefs, Helmut Friess, Jörg Kleeff, Mert Erkan
Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-associated mortality globally. Interactions of the cancer cells with the tumor microenvironment are essential carcinogenic features for the majority of solid tumors, such as pancreatic cancer. The present study investigated the role of stromal activation in NSCLC and analyzed the surgical specimens of 93 patients by immunohistochemistry with regard to periostin (an extracellular matrix protein), α-smooth muscle actin (α-SMA; a marker of myofibroblasts) and cluster of differentiation 31 (CD31; a marker of endothelial cells), and the activated stroma index...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27864347/human-pancreatic-cancer-cells-induce-a-myd88-dependent-stromal-response-to-promote-a-tumor-tolerant-immune-microenvironment
#14
Daniel Delitto, Andrea E Delitto, Bayli B DiVita, Kien Pham, Song Han, Emily R Hartlage, Brittney N Newby, Michael H Gerber, Kevin E Behrns, Lyle L Moldawer, Ryan M Thomas, Thomas J George, Todd M Brusko, Clayton E Mathews, Chen Liu, Jose G Trevino, Steven J Hughes, Shannon M Wallet
Cancer cells exert mastery over the local tumor-associated stroma (TAS) to configure protective immunity within the tumor microenvironment. The immunomodulatory character of pancreatic lysates of patients with cancer differs from those with pancreatitis. In this study, we evaluated the cross-talk between pancreatic cancer and its TAS in primary human cell culture models. Upon exposure of TAS to pancreatic cancer cell-conditioned media, we documented robust secretion of IL6 and IL8. This TAS response was MyD88-dependent and sufficient to directly suppress both CD4(+) and CD8(+) T-cell proliferation, inducing Th17 polarization at the expense of Th1...
February 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/27858181/intratumor-stromal-proportion-predicts-aggressive-phenotype-of-gastric-signet-ring-cell-carcinomas
#15
Dakeun Lee, In-Hye Ham, Sang Yong Son, Sang-Uk Han, Young-Bae Kim, Hoon Hur
OBJECTIVE: The aim of this study was to evaluate the prognostic significance of the intratumor stromal proportion in gastric signet ring cell (SRC) carcinomas. BACKGROUND: Cancer stroma, as exemplified by cancer-associated fibroblasts (CAFs), plays critical roles in cancer proliferation, invasion, and metastasis. METHODS: One hundred seventy-five SRC carcinoma cases were classified according to the intratumor desmoplastic stromal proportion to then analyze the clinicopathologic characteristics of stroma-rich cases...
November 17, 2016: Gastric Cancer
https://www.readbyqxmd.com/read/27851969/epigenomic-deconvolution-of-breast-tumors-reveals-metabolic-coupling-between-constituent-cell-types
#16
Vitor Onuchic, Ryan J Hartmaier, David N Boone, Michael L Samuels, Ronak Y Patel, Wendy M White, Vesna D Garovic, Steffi Oesterreich, Matt E Roth, Adrian V Lee, Aleksandar Milosavljevic
Cancer progression depends on both cell-intrinsic processes and interactions between different cell types. However, large-scale assessment of cell type composition and molecular profiles of individual cell types within tumors remains challenging. To address this, we developed epigenomic deconvolution (EDec), an in silico method that infers cell type composition of complex tissues as well as DNA methylation and gene transcription profiles of constituent cell types. By applying EDec to The Cancer Genome Atlas (TCGA) breast tumors, we detect changes in immune cell infiltration related to patient prognosis, and a striking change in stromal fibroblast-to-adipocyte ratio across breast cancer subtypes...
November 15, 2016: Cell Reports
https://www.readbyqxmd.com/read/27797069/igg4-related-sclerosing-mesenteritis-causing-bowel-obstruction-a-case-report
#17
Atsushi Abe, Tatsuya Manabe, Nobuyoshi Takizawa, Takashi Ueki, Daisuke Yamada, Kinuko Nagayoshi, Yoshihiko Sadakari, Hayato Fujita, Shuntaro Nagai, Hidetaka Yamamoto, Yoshinao Oda, Masafumi Nakamura
Sclerosing mesenteritis (SM) is a rare inflammatory and fibrosing disease primarily involving the small-bowel mesentery. Recently, SM was reported to be closely related to IgG4-related disease (IgG4-RD). This report describes a patient with SM associated with IgG4-RD. A 77-year-old woman with a history of surgery for ectopic pregnancy and wound dehiscence presented with intestinal obstruction. Abdominal enhanced computed tomography (CT) revealed an enhanced, radially shaped, oval mass, 3 cm in diameter, with an unclear rim in the mesentery of the distal ileum, which may have involved the distal ileum...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27792935/tissue-transglutaminase-activates-cancer-associated-fibroblasts-and-contributes-to-gemcitabine-resistance-in-pancreatic-cancer
#18
Jiyoon Lee, Bakhtiyor Yakubov, Cristina Ivan, David R Jones, Andrea Caperell-Grant, Melissa Fishel, Horacio Cardenas, Daniela Matei
Resistance to chemotherapy is a hallmark of pancreatic ductal adenocarcinoma (PDA) and has been partly attributed to the dense desmoplastic stroma, which forms a protective niche for cancer cells. Tissue transglutaminase (TG2), a Ca(2+)-dependent enzyme, is secreted by PDA cells and cross-links proteins in the tumor microenvironment (TME) through acyl-transfer between glutamine and lysine residues, promoting PDA growth. The objective of the current study was to determine whether secreted TG2 by PDA cells alters the response of pancreatic tumors to gemcitabine...
November 2016: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/27769871/re-evaluation-of-maml2-fusion-negative-mucoepidermoid-carcinoma-a-subgroup-being-actually-hyalinizing-clear-cell-carcinoma-of-the-salivary-gland-with-ewsr1-translocation
#19
Min-Shu Hsieh, Hsuang Wang, Yi-Hsuan Lee, Jenq-Yuh Ko, Yih-Leong Chang
Hyalinizing clear cell carcinoma (HCCC) is a rare salivary gland tumor with a specific EWSR1-ATF1 fusion gene and can have mucin production. Mucoepidermoid carcinoma (MEC) with a clear cell component is its morphologic mimic. Using MAML2 fluorescence in situ hybridization (FISH), a total of 49 MEC cases were separated into MAML2 fusion-positive (32 cases) and MAML2 fusion-negative groups (17 cases). This study used EWSR1 FISH to investigate MAML2 fusion-negative cases to identify previously unrecognized HCCC...
October 18, 2016: Human Pathology
https://www.readbyqxmd.com/read/27721275/evaluation-of-pathological-parameters-and-morphometric-data-of-desmoplastic-lobular-breast-carcinoma
#20
Ivan R Ilic, Nikola M Stojanović, Pavle J Randjelović, Marina N Mihajlović, Niko S Radulović, Ratko S Ilić
BACKGROUND: Invasive lobular breast cancer (ILC) is the second most frequent form of breast cancer. While cancer cells are regularly investigated, tumor stroma represents a highly unexplored field. AIMS: The aim of this study is to perform a detailed investigation of clinical, immunohistochemical, and morphometric characteristics of desmoplastic (D) and nondesmoplastic (ND) ILC. MATERIALS AND METHODS: This study included twenty cases of ILC that were divided into two groups designated as D and ND groups...
October 2016: Indian Journal of Pathology & Microbiology
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