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tumor stroma ratio

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https://www.readbyqxmd.com/read/29904148/intra-individual-gene-expression-variability-of-histologically-normal-breast-tissue
#1
Xuezheng Sun, Yue Shan, Quefeng Li, Lynn Chollet-Hinton, Erin L Kirk, Gretchen L Gierach, Melissa A Troester
Several studies have sought to identify novel transcriptional biomarkers in normal breast or breast microenvironment to predict tumor risk and prognosis. However, systematic efforts to evaluate intra-individual variability of gene expression within normal breast have not been reported. This study analyzed the microarray gene expression data of 288 samples from 170 women in the Normal Breast Study (NBS), wherein multiple histologically normal breast samples were collected from different block regions and different sections at a given region...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29872507/prognostic-significance-of-immune-cells-in-non-small-cell-lung-cancer-meta-analysis
#2
Ross A Soo, Zhaojin Chen, Rebecca Siew Yan Teng, Hon-Lyn Tan, Barry Iacopetta, Bee Choo Tai, Richie Soong
Background: Tumor-associated immune cells are prognostic in non-small cell lung cancer (NSCLC) but findings have been conflicting. Objectives: To determine the prognostic role of immune cells according to localization in NSCLC patients. Methods: A systematic literature review and meta-analysis was performed on dendritic cell (DC), tumor associated macrophages (TAM), mast cells (MC), natural killer (NK) cells, T and B cells and tumor CTLA-4 and PD-L1 studies...
May 15, 2018: Oncotarget
https://www.readbyqxmd.com/read/29787931/prognostic-impact-of-tumor-stroma-ratio-in-oral-squamous-cell-carcinoma-a-pilot-study
#3
Kochli Channappa Niranjan, Niharika Abhay Sarathy
BACKGROUND: Several prognostic indicators have been used for many decades in an attempt to predict clinical behaviour of Oral Squamous Cell Carcinoma (OSCC). The prognostic value of TSR is yet to be explored in OSCC. Hence, the aim of the present study was to evaluate the prognostic value of TSR in OSCC patients. METHODOLOGY: A cohort of 60 histologically diagnosed cases of OSCC who underwent Radical Neck Dissection was included in the study. TSR was assessed and patients with >50% intratumor stroma were quantified as the stroma-poor group and those with <50% as the stroma-rich group...
May 17, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29787818/pathological-significance-and-prognostic-roles-of-densities-of-cd57-cells-cd68-cells-and-mast-cells-and-their-ratios-in-clear-cell-renal-cell-carcinoma
#4
Hiromi Nakanishi, Yasuyoshi Miyata, Yasushi Mochizuki, Takuji Yasuda, Yuichiro Nakamura, Kyohei Araki, Yuji Sagara, Tomohiro Matsuo, Kojiro Ohba, Hideki Sakai
The immune system is closely associated with malignant behavior in renal cell carcinoma (RCC). Therefore, understanding the pathological roles of immune cells in tumor stroma is essential to discuss the pathological characteristics of RCC. In this study, the clinical significance of densities of CD57+ cells, CD68+ cells, and mast cells, and their ratios were investigated in patients with clear cell RCC. The densities of CD57+, CD68+, and mast cells were evaluated by immunohistochemical techniques in 179 patients...
May 19, 2018: Human Pathology
https://www.readbyqxmd.com/read/29767505/tuned-density-of-anti-tissue-factor-antibody-fragment-onto-sirna-loaded-polyion-complex-micelle-for-optimizing-targetability-into-pancreatic-cancer-cells
#5
Hyun Su Min, Hyun Jin Kim, Jooyeon Ahn, Mitsuru Naito, Kotaro Hayashi, Kazuko Toh, Beob Soo Kim, Yasuhiro Matsumura, Ick Chan Kwon, Kanjiro Miyata, Kazunori Kataoka
Antibody fragment (Fab')-installed polyion complex (PIC) micelles were constructed to improve targetability of small interfering RNA (siRNA) delivery to pancreatic cancer cells. To this end, we synthesized a block copolymer of azide-functionalized poly(ethylene glycol) (PEG) and poly(L-lysine) (PLL), and prepared PIC micelles with siRNA. Then, a dibenzylcyclooctyne (DBCO)-modified anti-human tissue factor (TF) Fab' was conjugated to azido groups on the micellar surface. A fluorescence correlation spectroscopic (FCS) analysis revealed that 1, 2, or 3 molecule(s) of Fab'(s) were installed onto one micellar nanoparticle according to the feeding ratio of Fab' (or DBCO) to micelle (or azide)...
May 16, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29748845/lipomas-of-the-oral-cavity-utility-of-mdm2-and-cdk4-in-avoiding-overdiagnosis-as-atypical-lipomatous-tumor
#6
Ivan J Stojanov, Adrian Mariño-Enriquez, Nacef Bahri, Vickie Y Jo, Sook-Bin Woo
Traumatized lipomas with degenerative change may demonstrate histopathologic features that mimic atypical lipomatous tumor (ALT). Previously reported series of ALT involving the oral cavity preceded routine use of MDM2 and CDK4 immunohistochemistry. Our aim is to evaluate MDM2 and CDK4 immunohistochemical expression in adipocytic tumors arising in this site, in conjunction with the histiocytic marker PU.1, to determine whether MDM2 and CDK4 impacts classification. 17 cases originally diagnosed as ALT were retrieved and immunohistochemical studies for MDM2, CDK4 and PU...
May 10, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29627937/poor-prognosis-in-epstein-barr-virus-negative-gastric-cancer-with-lymphoid-stroma-is-associated-with-immune-phenotype
#7
Charles J Cho, Hyo Jeong Kang, Yeon-Mi Ryu, Young Soo Park, Hui Jeong Jeong, Young-Mi Park, Hyun Lim, Jeong Hoon Lee, Ho June Song, Hwoon-Yong Jung, Sang-Yeob Kim, Seung-Jae Myung
BACKGROUND: Gastric cancer with lymphoid stroma (GCLS) is pathologically characterized by poorly developed tubular structures with a prominent lymphocytic infiltration. Its clinical and prognostic features differ in patients positive and negative for Epstein-Barr virus (EBV) infection. This study analyzed the expression of programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and the density of tumor-infiltrating lymphocytes (TILs) including CD3+ and CD8+ T cells, as well as their prognostic significance in patients with GCLS...
April 7, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/29581358/deregulated-mucosal-immune-surveillance-through-gut-associated-regulatory-t-cells-and-pd-1-t-cells-in-human-colorectal-cancer
#8
Hanae Fujimoto, Yoriko Saito, Kenoki Ohuchida, Eiryo Kawakami, Saera Fujiki, Takashi Watanabe, Rintaro Ono, Akiko Kaneko, Shinsuke Takagi, Yuho Najima, Atsushi Hijikata, Lin Cui, Takashi Ueki, Yoshinao Oda, Shohei Hori, Osamu Ohara, Masafumi Nakamura, Takashi Saito, Fumihiko Ishikawa
Disturbed balance between immune surveillance and tolerance may lead to poor clinical outcomes in some malignancies. In paired analyses of adenocarcinoma and normal mucosa from 142 patients, we found a significant increase of the CD4/CD8 ratio and accumulation of regulatory T cells (Tregs) within the adenocarcinoma. The increased frequency of Tregs correlated with the local infiltration and extension of the tumor. There was concurrent maturation arrest, upregulation of programmed death-1 expression, and functional impairment in CD8+ T cells (CTLs) isolated from the adenocarcinoma...
May 1, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29571999/the-ratio-of-cancer-cells-to-stroma-within-the-invasive-area-is-a-histologic-prognostic-parameter-of-lung-adenocarcinoma
#9
Tomohiro Ichikawa, Keiju Aokage, Masato Sugano, Tomohiro Miyoshi, Motohiro Kojima, Satoshi Fujii, Takeshi Kuwata, Atsushi Ochiai, Kenji Suzuki, Masahiro Tsuboi, Genichiro Ishii
OBJECTIVES: This study evaluated whether the proportion of cancer cells to non-cancerous stroma within the invasive area is associated with the prognosis of patients with lung adenocarcinoma. MATERIALS AND METHODS: A total of 127 patients with lung adenocarcinomas with tumors larger than 3 cm in total size were enrolled in this study. We classified the tumors according to the ratio of area occupied by cancer cells within the invasive area (Type A: more than 50% of the invasive area, Type B: 10-50%, and Type C: less than 10%) and analyzed the clinicopathological differences between Types A, B, and C...
April 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29552405/investigation-of-tissue-cellularity-at-the-tip-of-the-core-biopsy-needle-with-optical-coherence-tomography
#10
Nicusor Iftimia, Jesung Park, Gopi Maguluri, Savitri Krishnamurthy, Amanda McWatters, Sharjeel H Sabir
We report the development and the pre-clinical testing of a new technology based on optical coherence tomography (OCT) for investigating tissue composition at the tip of the core biopsy needle. While ultrasound, computed tomography, and magnetic resonance imaging are routinely used to guide needle placement within a tumor, they still do not provide the resolution needed to investigate tissue cellularity (ratio between viable tumor and benign stroma) at the needle tip prior to taking a biopsy core. High resolution OCT imaging, however, can be used to investigate tissue morphology at the micron scale, and thus to determine if the biopsy core would likely have the expected composition...
February 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29523158/study-on-the-progression-types-of-cancer-in-patients-with-breast-cancer-undergoing-eribulin-chemotherapy-and-tumor-microenvironment
#11
Shinichiro Kashiwagi, Gen Tsujio, Yuka Asano, Wataru Goto, Koji Takada, Katsuyuki Takahashi, Tamami Morisaki, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Masahiko Ohsawa, Kosei Hirakawa, Masaichi Ohira
BACKGROUND: Recently, the concepts of progression due to pre-existing lesions (PPL) and progression due to new metastasis (PNM) have been proposed to differentiate the progression types of treatment-resistant cancers. Previously, the differences between these two progression types did not affect the determination of treatment strategies since both PPL and PNM are classified as progressive disease based on the response evaluation criteria in solid tumors (RECIST) diagnostic criteria. On the other hand, tumor infiltrating lymphocytes (TILs) are effective when used as indicators for monitoring the immune tumor microenvironment (iTME) in the cancer host, and TILs play an important role as biomarkers in predicting prognosis and therapeutic effects...
March 9, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29522577/women-with-adenomyosis-are-at-higher-risks-of-endometrial-and-thyroid-cancers-a-population-based-historical-cohort-study
#12
Chih-Ching Yeh, Fu-Hsiung Su, Chii-Ruey Tzeng, Chih-Hsin Muo, Wen-Chang Wang
OBJECTIVE: Both adenomyosis and endometriosis are characterized by the presence of ectopic endometrial glands and stroma and have been suggested to share some characteristics with malignant tumors. Although accumulating evidence indicates that endometriosis is associated with some cancer types, the cancer risks in patients with adenomyosis have been rarely examined. In this study, we investigated the relationship between adenomyosis and risks of common cancers. METHODS: This study included a cohort of 12,447 women with adenomyosis but not endometriosis, born in 1951-1984, and a cohort of 124,470 adenomyosis-free women matched by birth year...
2018: PloS One
https://www.readbyqxmd.com/read/29471527/the-heterogeneity-between-lynch-associated-and-sporadic-mmr-deficiency-in-colorectal-cancers
#13
Guo-Chen Liu, Ran-Yi Liu, Jun-Ping Yan, Xin An, Wu Jiang, Yi-Hong Ling, Jie-Wei Chen, Jin-Xin Bei, Xiao-Yu Zuo, Mu-Yan Cai, Ze-Xian Liu, Zhi-Xiang Zuo, Ji-Hong Liu, Zhi-Zhong Pan, Pei-Rong Ding
Background: Previous studies demonstrated that prognosis of germline deficiency in mismatch repair protein (dMMR) was different from that of sporadic dMMR. The underlying mechanism has not been studied. Methods: From a prospectively maintained database, we collected dMMR colorectal cancer (CRC) patients identified by postoperative immunohistochemistry screening. According to genetic test, patients were grouped as Lynch-associated or sporadic dMMR. We compared the clinical-pathological features, prognosis, and immunoreactive differences between the two groups...
February 20, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29467127/quantitative-analysis-of-immune-infiltrates-in-primary-melanoma
#14
Robyn D Gartrell, Douglas K Marks, Thomas D Hart, Gen Li, Danielle R Davari, Alan Wu, Zoë Blake, Yan Lu, Kayleigh N Askin, Anthea Monod, Camden L Esancy, Edward C Stack, Dan Tong Jia, Paul M Armenta, Yichun Fu, Daisuke Izaki, Bret Taback, Raul Rabadan, Howard L Kaufman, Charles G Drake, Basil A Horst, Yvonne M Saenger
Novel methods to analyze the tumor microenvironment (TME) are urgently needed to stratify melanoma patients for adjuvant immunotherapy. Tumor-infiltrating lymphocyte (TIL) analysis, by conventional pathologic methods, is predictive but is insufficiently precise for clinical application. Quantitative multiplex immunofluorescence (qmIF) allows for evaluation of the TME using multiparameter phenotyping, tissue segmentation, and quantitative spatial analysis (qSA). Given that CD3+ CD8+ cytotoxic lymphocytes (CTLs) promote antitumor immunity, whereas CD68+ macrophages impair immunity, we hypothesized that quantification and spatial analysis of macrophages and CTLs would correlate with clinical outcome...
April 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29448309/the-value-of-additional-bevacizumab-in-patients-with-high-risk-stroma-high-colon-cancer-a-study-within-the-quasar2-trial-an-open-label-randomized-phase-3-trial
#15
Anouck Huijbers, Gabi W van Pelt, Rachel S Kerr, Elaine C Johnstone, Rob A E M Tollenaar, David J Kerr, Wilma E Mesker
INTRODUCTION: Patients with a high stroma percentage within the primary tumor have a poor prognosis. In this study, we investigate whether anti-angiogenic therapy might improve survival of patients with a stroma-high profile with potentially increased angiogenesis. MATERIALS AND METHODS: Tissue samples of the primary tumor of 965 colon cancer patients participating in the QUASAR2 trial were analyzed for tumor-stroma ratio (TSR). Stroma-high (>50%) and stroma-low (≤50%) groups were evaluated with respect to survival...
April 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29435735/immunosuppressive-tumor-microenvironment-of-usual-interstitial-pneumonia-associated-squamous-cell-carcinoma-of-the-lung
#16
Takuya Ueda, Keiju Aokage, Hiroyoshi Nishikawa, Shinya Neri, Hiroshi Nakamura, Masato Sugano, Kenta Tane, Tomohiro Miyoshi, Motohiro Kojima, Satoshi Fujii, Takeshi Kuwata, Atsushi Ochiai, Masahiko Kusumoto, Kenji Suzuki, Masahiro Tsuboi, Genichiro Ishii
PURPOSE: Patients with usual interstitial pneumonia (UIP) often develop lung cancer. However, the biological features of lung cancer associated with UIP remain unknown. The aim of this study was to elucidate the clinicopathological characteristics of UIP-associated squamous cell carcinoma (SqCC). METHODS: A total of 244 patients with p-stage I lung SqCC who underwent complete surgical resection were enrolled in this study. Clinicopathological differences between UIP-associated SqCC and non-UIP SqCC were examined...
May 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29427291/prognostic-impact-of-tumour-stroma-ratio-in-early-stage-oral-tongue-cancers
#17
Alhadi Almangush, Ilkka Heikkinen, Nassira Bakhti, Laura K Mäkinen, Joonas H Kauppila, Matti Pukkila, Jaana Hagström, Jussi Laranne, Ylermi Soini, Luiz P Kowalski, Reidar Grénman, Caj Haglund, Antti A Mäkitie, Ricardo D Coletta, Ilmo Leivo, Tuula Salo
AIMS: Oral tongue squamous cell carcinoma (OTSCC) has a relatively poor outcome, and there is a need to identify better prognostic factors. Recently, tumour-stroma ratio (TSR) has been associated with prognosis in several cancers. The aim of this multi-institutional study was to evaluate the prognostic value of TSR from original haematoxylin and eosin (HE)-stained tumour-resection slides in a series of early-stage (cT1-2N0) OTSCC patients. METHODS AND RESULTS: A TSR cutoff value of 50% was used to divide the patients into stroma-rich (≥50%) and stroma-poor (<50%) groups...
February 10, 2018: Histopathology
https://www.readbyqxmd.com/read/29383131/development-of-a-reliable-and-accurate-algorithm-to-quantify-the-tumor-immune-stroma-qtis-across-tumor-types
#18
Rainer Christoph Miksch, Jingcheng Hao, Markus Bo Schoenberg, Katharina Dötzer, Friederike Schlüter, Maximilian Weniger, Shuai Yin, Steffen Ormanns, Jan Goesta D'Haese, Markus Otto Guba, Jens Werner, Barbara Mayer, Alexandr V Bazhin
The tumor microenvironment plays an important role in the tumor biology. Overall survival of tumor patients after resection is influenced by tumor-infiltrating lymphocytes (TILs) as a component of the tumor stroma. However, it is not clear how to assess TILs in the tumor stroma due to heterogeneous methods in different cancer types. Therefore, we present a novel Quantification of the Tumor immune Stroma (QTiS) Algorithm to reliably and accurately quantify cells in the tumor stroma. Immunohistochemical staining of CD3 and CD8 cells in sections of metastatic colorectal cancer (mCRC), ovarian cancer (OvCa), hepatocellular carcinoma (HCC), and pancreatic ductal adenocarcinoma (PDAC), alltogether N = 80, was performed...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29359949/comparison-of-peritumoral-stromal-tissue-stiffness-obtained-by-shear-wave-elastography-between-benign-and-malignant-breast-lesions
#19
Hye Sun Park, Hee Jung Shin, Ki Chang Shin, Joo Hee Cha, Eun Young Chae, Woo Jung Choi, Hak Hee Kim
Background Aggressive breast cancers produce abnormal peritumoral stiff areas, which can differ between benign and malignant lesions and between different subtypes of breast cancer. Purpose To compare the tissue stiffness of the inner tumor, tumor border, and peritumoral stroma (PS) between benign and malignant breast masses by shear wave elastography (SWE). Material and Methods We enrolled 133 consecutive patients who underwent preoperative SWE. Using OsiriX commercial software, we generated multiple 2-mm regions of interest (ROIs) in a linear arrangement on the inner tumor, tumor border, and PS...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29326439/lung-fibroblasts-promote-metastatic-colonization-through-upregulation-of-stearoyl-coa-desaturase-1-in-tumor-cells
#20
Guanghua Liu, Shi Feng, Lin Jia, Chunying Wang, Yan Fu, Yongzhang Luo
As a rate-limiting step in metastasis, metastatic colonization requires survival signals from supportive stroma. However, the mechanisms driving this process are incompletely understood. Here, we showed that the proliferation of B16F10 cells was promoted when cocultured with lung fibroblasts. Meanwhile, co-injection of B16F10 tumor cells with mouse lung fibroblasts significantly increased lung metastasis. Based on GEO database, we identified stearoyl-CoA desaturase 1 (SCD1) as a novel factor promoting metastatic colonization...
March 2018: Oncogene
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