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https://www.readbyqxmd.com/read/27936434/mineralocorticoid-receptor-haplotype-estradiol-progesterone-and-emotional-information-processing
#1
Danielle A Hamstra, E Ronald de Kloet, Ina Quataert, Myrthe Jansen, Willem Van der Does
BACKGROUND: Carriers of MR-haplotype 1 and 3 (GA/CG; rs5522 and rs2070951) are more sensitive to the influence of oral contraceptives (OC) and menstrual cycle phase on emotional information processing than MR-haplotype 2 (CA) carriers. We investigated whether this effect is associated with estradiol (E2) and/or progesterone (P4) levels. METHOD: Healthy MR-genotyped premenopausal women were tested twice in a counterbalanced design. Naturally cycling (NC) women were tested in the early-follicular and mid-luteal phase and OC-users during OC-intake and in the pill-free week...
November 30, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27936416/antigen-recognition-triggered-drug-delivery-mediated-by-nanocapsule-functionalized-cytotoxic-t-cells
#2
R Brad Jones, Stephanie Mueller, Sudha Kumari, Vlad Vrbanac, Shy Genel, Andrew M Tager, Todd M Allen, Bruce D Walker, Darrell J Irvine
Cytotoxic T-Lymphocytes (CTLs) kill pathogen-infected or transformed cells following interaction of their T-cell receptors (TCRs) with foreign (e.g. virus-derived) peptides bound to MHC-I molecules on the target cell. TCR binding triggers CTLs to secrete perforin, which forms pores in the target cell membrane, promoting target death. Here, we show that by conjugating drug-loaded lipid nanoparticles to the surface of CTLs, their lytic machinery can be co-opted to lyse the cell-bound drug carrier, providing triggered release of drug cargo upon target cell recognition...
November 25, 2016: Biomaterials
https://www.readbyqxmd.com/read/27936405/identification-of-lipopolysaccharide-interacting-plasma-membrane-type-proteins-in-arabidopsis-thaliana
#3
Cornelius S Vilakazi, Ian A Dubery, Lizelle A Piater
Lipopolysaccharide (LPS) is an amphiphatic bacterial glycoconjugate found on the external membrane of Gram-negative bacteria. This endotoxin is considered as a microbe-associated molecular pattern (MAMP) molecule and has been shown to elicit defense responses in plants. Here, LPS-interacting proteins from Arabidopsis thaliana plasma membrane (PM)-type fractions were captured and identified in order to investigate those involved in LPS perception and linked to triggering of innate immune responses. A novel proteomics-based affinity-capture strategy coupled to liquid chromatography-tandem mass spectrometry (LC-MS/MS) was employed for the enrichment and identification of LPS-interacting proteins...
November 30, 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/27936367/alcohol-warning-label-perceptions-do-warning-sizes-and-plain-packaging-matter
#4
Mohammed Al-Hamdani, Steven M Smith
OBJECTIVE: There is a dearth of research on the effectiveness of stringent alcohol warning labels. Our experiment tested whether increasing the size of an alcohol health warning lowers product-based ratings. We examined whether plain packaging lowers ratings of alcohol products and the consumers who use them, increases ratings of bottle "boringness," and enhances warning recognition compared with branded packaging. METHOD: A total of 440 adults (51.7% female) viewed one of three warning sizes (50%, 75%, or 90% of label surface) on either a plain or branded bottle of distilled spirits, wine, and beer...
January 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/27936273/can-should-theories-of-crowding-be-unified
#5
Mehmet N Agaoglu, Susana T L Chung
Objects in clutter are difficult to recognize, a phenomenon known as crowding. There is little consensus on the underlying mechanisms of crowding, and a large number of models have been proposed. There have also been attempts at unifying the explanations of crowding under a single model, such as the weighted feature model of Harrison and Bex (2015) and the texture synthesis model of Rosenholtz and colleagues (Balas, Nakano, & Rosenholtz, 2009; Keshvari & Rosenholtz, 2016). The goal of this work was to test various models of crowding and to assess whether a unifying account can be developed...
December 1, 2016: Journal of Vision
https://www.readbyqxmd.com/read/27936254/-the-iconographic-archive-what-does-the-visual-culture-of-the-origins-of-french-psychiatry-in-the-early-nineteenth-century-reveal-to-us
#6
Ginette Jubinville
This article constructs a new history of the birth of psychiatry that of its visual culture, through the study of heretofore unpublished and neglected archives.The analysis of artworks commissioned by the first French psychiatrists at the beginning of the nineteenth century highlights, in an exceptional way, the recognition of subjectivation and autonomy of the mentally sick person, which is the inherent hope of psychiatry's initial project.The artists who fulfilled the first psychiatrists' commissions expressed this ideal, which was conveyed both by the humanist philanthropy of early psychiatry and by the artistic vocabulary of the nineteenth century...
2016: Santé Mentale Au Québec
https://www.readbyqxmd.com/read/27936212/effect-of-simultaneous-bilingualism-on-speech-intelligibility-across-different-masker-types-modalities-and-signal-to-noise-ratios-in-school-age-children
#7
Rachel Reetzke, Boji Pak-Wing Lam, Zilong Xie, Li Sheng, Bharath Chandrasekaran
Recognizing speech in adverse listening conditions is a significant cognitive, perceptual, and linguistic challenge, especially for children. Prior studies have yielded mixed results on the impact of bilingualism on speech perception in noise. Methodological variations across studies make it difficult to converge on a conclusion regarding the effect of bilingualism on speech-in-noise performance. Moreover, there is a dearth of speech-in-noise evidence for bilingual children who learn two languages simultaneously...
2016: PloS One
https://www.readbyqxmd.com/read/27936125/automatic-coronary-artery-calcium-scoring-on-radiotherapy-planning-ct-scans-of-breast-cancer-patients-reproducibility-and-association-with-traditional-cardiovascular-risk-factors
#8
Sofie A M Gernaat, Ivana Išgum, Bob D de Vos, Richard A P Takx, Danny A Young-Afat, Noor Rijnberg, Diederick E Grobbee, Yolanda van der Graaf, Pim A de Jong, Tim Leiner, Desiree H J van den Bongard, Jean-Philippe Pignol, Helena M Verkooijen
OBJECTIVES: Coronary artery calcium (CAC) is a strong and independent predictor of cardiovascular disease (CVD) risk. This study assesses reproducibility of automatic CAC scoring on radiotherapy planning computed tomography (CT) scans of breast cancer patients, and examines its association with traditional cardiovascular risk factors. METHODS: This study included 561 breast cancer patients undergoing radiotherapy between 2013 and 2015. CAC was automatically scored with an algorithm using supervised pattern recognition, expressed as Agatston scores and categorized into five categories (0, 1-10, 11-100, 101-400, >400)...
2016: PloS One
https://www.readbyqxmd.com/read/27936122/association-of-odor-thresholds-and-responses-in-cerebral-blood-flow-of-the-prefrontal-area-during-olfactory-stimulation-in-patients-with-multiple-chemical-sensitivity
#9
Kenichi Azuma, Iwao Uchiyama, Mari Tanigawa, Ikuko Bamba, Michiyo Azuma, Hirohisa Takano, Toshikazu Yoshikawa, Kou Sakabe
Multiple chemical sensitivity (MCS) is a disorder characterized by nonspecific and recurrent symptoms from various organ systems associated with exposure to low levels of chemicals. Patients with MCS process odors differently than controls do. Previously, we suggested that this odor processing was associated with increased regional cerebral blood flow (rCBF) in the prefrontal area during olfactory stimulation using near-infrared spectroscopic (NIRS) imaging. The aim of this study was to investigate the association of odor thresholds and changes in rCBF during olfactory stimulation at odor threshold levels in patients with MCS...
2016: PloS One
https://www.readbyqxmd.com/read/27936046/the-ras-effector-interface-isoform-specific-differences-in-the-effector-binding-regions
#10
Hossein Nakhaeizadeh, Ehsan Amin, Saeideh Nakhaei-Rad, Radovan Dvorsky, Mohammad Reza Ahmadian
RAS effectors specifically interact with the GTP-bound form of RAS in response to extracellular signals and link them to downstream signaling pathways. The molecular nature of effector interaction by RAS is well-studied but yet still incompletely understood in a comprehensive and systematic way. Here, structure-function relationships in the interaction between different RAS proteins and various effectors were investigated in detail by combining our in vitro data with in silico data. Equilibrium dissociation constants were determined for the binding of HRAS, KRAS, NRAS, RRAS1 and RRAS2 to both the RAS binding (RB) domain of CRAF and PI3Kα, and the RAS association (RA) domain of RASSF5, RALGDS and PLCε, respectively, using fluorescence polarization...
2016: PloS One
https://www.readbyqxmd.com/read/27935955/online-3d-ear-recognition-by-combining-global-and-local-features
#11
Yahui Liu, Bob Zhang, Guangming Lu, David Zhang
The three-dimensional shape of the ear has been proven to be a stable candidate for biometric authentication because of its desirable properties such as universality, uniqueness, and permanence. In this paper, a special laser scanner designed for online three-dimensional ear acquisition was described. Based on the dataset collected by our scanner, two novel feature classes were defined from a three-dimensional ear image: the global feature class (empty centers and angles) and local feature class (points, lines, and areas)...
2016: PloS One
https://www.readbyqxmd.com/read/27935932/early-recognition-of-fibrodysplasia-ossificans-progressiva-important-for-the-clinician
#12
A Singh, G Pradhan, C Kumari, S Kapoor
Fibrodysplasia ossificans progressiva is a rare disorder of heterotopic ossification. Procedures like biopsy and surgery are known to be aggravating factors in promoting heterotopic ossification Clues to clinical diagnosis may therefore be a great advantage to treating orthopedician. Valgus deformity of great toe is an important diagnostic clue for treating physicians and thus aids in preventing the clinicians from subjecting the patients to unnecessary invasive and traumatic procedures. Hence clinical clues to early diagnosis are important in establishing the correct diagnosis and directing future management...
April 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27935907/eclampsia-feto-maternal-outcomes-in-a-tertiary-care-centre-in-eastern-nepal
#13
S Ghimire
INTRODUCTION: Eclampsia is a preventable and treatable cause of maternal morbidity and mortality with poor feto-maternal outcome in developing countries. Despite development in the level of health education expertise in human resources and institutional obstetric care in our country, the delay in early recognition of the problem, transportation to proper health facility and getting proper expert care are major hurdles to reduce complications. Therefore, we decided to study feto-maternal outcomes in our setting...
January 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27935717/the-role-of-unconventional-hydrogen-bonds-in-determining-bii-propensities-in-b-dna
#14
Alexandra Balaceanu, Marco Pasi, Pablo D Dans, Adam Hospital, Richard Lavery, Modesto Orozco
An accurate understanding of DNA backbone transitions is likely to be the key for elucidating the puzzle of the intricate sequence-dependent mechanical properties that govern most of the biologically relevant functions of the double helix. One factor believed to be important in indirect recognition within protein-DNA complexes is the combined effect of two DNA backbone torsions (ε and ζ) which give rise to the well-known BI/BII conformational equilibrium. In this work we explain the sequence-dependent BII propensity observed in RpY steps (R = purine; Y = pyrimidine) at the tetranucleotide level with the help of a previously undetected C-H···O contact between atoms belonging to adjacent bases...
December 9, 2016: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/27935680/self-assembling-nanocomposite-tectons
#15
Jianyuan Zhang, Peter J Santos, Paul A Gabrys, Sangho Lee, Caroline Liu, Robert J Macfarlane
The physical characteristics of composite materials are dictated by both the chemical composition and spatial configuration of each constituent phase. A major challenge in nanoparticle-based composites is developing methods to precisely dictate particle positions at the nanometer length scale, as this would allow complete control over nanocomposite structure-property relationships. In this work, we present a new class of building blocks called nanocomposite tectons (NCTs), which consist of inorganic nanoparticles grafted with a dense layer of polymer chains that terminate in molecular recognition units capable of programmed supramolecular bonding...
December 9, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27935661/bee-communities-along-a-prairie-restoration-chronosequence-similar-abundance-and-diversity-distinct-composition
#16
Rebecca K Tonietto, John S Ascher, Daniel J Larkin
Recognition of the importance of bee conservation has grown in response to declines of managed honey bees and some wild bee species. Habitat loss has been implicated as a leading cause of declines, suggesting that ecological restoration is likely to play an increasing role in bee conservation efforts. In the Midwestern USA, restoration of tallgrass prairie has traditionally targeted plant community objectives without explicit consideration for bees. However, restoration of prairie vegetation is likely to provide ancillary benefits to bees through increased foraging and nesting resources...
December 9, 2016: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/27935612/fabricating-polyacrylamide-microbeads-by-inverse-emulsification-to-mimic-the-size-and-elasticity-of-living-cells
#17
Nicholas R Labriola, Edith Mathiowitz, Eric M Darling
Inverse emulsification was used to fabricate polyacrylamide (PAAm) microbeads with size and elastic properties similar to typical, mammalian cells. These biomimicking microbeads could be fluorescently stained and functionalized with a collagen type-I coating, post-polymerization, for tracking bead locations and promoting cell recognition/binding, respectively. By occupying a previously unfilled range of sizes and mechanical properties, these microbeads may find unique use in both biomedical and materials applications...
December 9, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27935424/structural-dynamics-and-dna-interaction-of-human-tfiid
#18
Eva Nogales, Jie Fang, Robert K Louder
TFIID is a large protein complex required for the recognition and binding of eukaryotic gene core promoter sequences and for the recruitment of the rest of the general transcription factors involved in initiation of eukaryotic protein gene transcription. Cryo-electron microscopy studies have demonstrated the conformational complexity of human TFIID, where one third of the mass of the complex can shift its position by well over 100 Å. This conformational plasticity appears to be linked to the capacity of TFIID to bind DNA and suggests how it would allow both the recognition of different core promoter elements and the tuning of its binding affinity by regulatory factors...
December 9, 2016: Transcription
https://www.readbyqxmd.com/read/27935351/childhood-constipation-recognition-management-and-the-role-of-the-nurse
#19
James Schuster Bruce, Catherine Schuster Bruce, Hayley Short, Siba Prosad Paul
Constipation is a common childhood condition that health professionals will encounter in many different settings. The majority of these cases of childhood constipation are idiopathic in nature. It is considered to exhibit the 'tip of the iceberg' phenomenon as a large number of cases remain undetected due to under-recognition by families, embarrassment regarding the condition, fear of receiving a negative response from health professionals, or parental belief there is actually something more seriously wrong and failure to accept the diagnosis...
December 8, 2016: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/27935290/aromatic-functionality-of-target-proteins-influences-monomer-selection-for-creating-artificial-antibodies-on-plasmonic-biosensors
#20
Rong Hu, Jingyi Luan, Evan D Kharasch, Srikanth Singamaneni, Jeremiah J Morrissey
Natural antibodies used as biorecognition elements suffer from numerous shortcomings, such as limited chemical and environmental stability and cost. Artificial antibodies based on molecular imprinting are an attractive alternative to natural antibodies. We investigated the role of aromatic interactions in target recognition capabilities of artificial antibodies. Three proteins with different aromatic amino acid content were employed as model targets. Artificial antibodies were formed on nanostructures using combinations of silane monomers of varying aromatic functionality...
December 9, 2016: ACS Applied Materials & Interfaces
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