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https://www.readbyqxmd.com/read/28454292/dna-vaccine-encoding-human-papillomavirus-antigens-flanked-by-a-signal-peptide-and-a-kdel-sequence-induces-a-potent-therapeutic-antitumor-effect
#1
Jose J Perez-Trujillo, Rodolfo Garza-Morales, Jose A Barron-Cantu, Gabriel Figueroa-Parra, Aracely Garcia-Garcia, Humberto Rodriguez-Rocha, Jaime Garcia-Juarez, Gerardo E Muñoz-Maldonado, Odila Saucedo-Cardenas, Roberto Montes-De-Oca-Luna, Maria De Jesus Loera-Arias
Cellular immune responses play a critical role in the eradication of intracellular infections and malignant cells through the recognition and subsequent removal of the infection or malignant cells. Effective antigen presentation is crucial for stimulating the immune system against malignant cells. Calreticulin (CRT) has been used to improve antigen presentation. However, CRT overexpression has been previously associated with the development of pancreatic and breast cancer. The import and retention signals of CRT in the endoplasmic reticulum (ER) can be used to overcome CRT overexpression...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454191/-distress-main-burdens-engagement-motivators-and-needs-of-fulltime-and-volunteer-refugee-aid-workers
#2
Theresa Grimm, Ekaterini Georgiadou, Andrea Silbermann, Katharina Junker, Winfried Nisslbeck, Yesim Erim
In the psychosomatic department of the University Hospital of Erlangen trainings were conducted for active refugee aid workers with start in January, 2016. Meanwhile 49 helpers participated in the training and 45 of them filled out a survey questionnaire. Perceived distress when providing care for refugees, as well as engagement motivation and further training needs were explored. Furthermore, depressive symptoms as well as the prevalence of traumatic experiences were investigated. The main burden was experienced through lacking freedom of action on the background of legal regulations...
April 28, 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28454076/carbazole-based-nanoprobe-for-selective-recognition-of-fe-3-ion-in-aqueous-medium-spectroscopic-insight
#3
Sonali B Suryawanshi, Prasad G Mahajan, Anita J Bodake, Govind B Kolekar, Shivajirao R Patil
A simple carbazole based nanoprobe prepared by reprecipitation method shows selective sensing behavior for Fe(3+) ion in aqueous medium. The prepared SDS capped 9-phenyl carbazole nanoparticles (9-PCzNPs) has narrower particle size distribution with an average diameter 35nm and zeta potential of -34.3mV predicted a good stability with negative surface charge over the nanoparticles. The Field Emission Scanning Electron Microscopy (FE-SEM) image showed cubic shape morphology of nanoparticles. The aqueous suspension of SDS capped 9-phenyl carbazole nanoparticles exhibited aggregation induced enhanced red shifted intense emission in comparison with the emission arising from dilute solution of 9-phenyl carbazole in DCM...
April 18, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28454070/principles-and-applications-of-photoelectrochemical-sensing-strategies-based-on-biofunctionalized-nanostructures
#4
REVIEW
Yang Zang, Jianping Lei, Huangxian Ju
Photoelectrochemical (PEC) biosensing is a popular research hotspot that has attracted substantial attention from chemists and biologists due to its low cost and desirable sensitivity. The PEC biosensing mainly refers to the influence of the interaction between recognition element and analyte on photocurrent signal, which involves the charge and energy transfer of PEC reaction between electron donor/acceptor and photoactive material upon light irradiation. Understanding the fundamentals of PEC strategy benefits the development of next-generation PEC sensors...
April 22, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28453854/the-dynamics-of-the-monomeric-restriction-endonuclease-bcni-during-its-interaction-with-dna
#5
Georgij Kostiuk, Jasmina Dikic, Friedrich W Schwarz, Giedrius Sasnauskas, Ralf Seidel, Virginijus Siksnys
Endonucleases that generate DNA double strand breaks often employ two independent subunits such that the active site from each subunit cuts either DNA strand. Restriction enzyme BcnI is a remarkable exception. It binds to the 5΄-CC/SGG-3΄ (where S = C or G, '/' designates the cleavage position) target as a monomer forming an asymmetric complex, where a single catalytic center approaches the scissile phosphodiester bond in one of DNA strands. Bulk kinetic measurements have previously shown that the same BcnI molecule cuts both DNA strands at the target site without dissociation from the DNA...
April 27, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28453818/downstream-element-determines-rnase-y-cleavage-of-the-saepqrs-operon-in-staphylococcus-aureus
#6
Gabriella Marincola, Christiane Wolz
In gram-positive bacteria, RNase J1, RNase J2 and RNase Y are thought to be major contributors to mRNA degradation and maturation. In Staphylococcus aureus, RNase Y activity is restricted to regulating the mRNA decay of only certain transcripts. Here the saePQRS operon was used as a model to analyze RNase Y specificity in living cells. A RNase Y cleavage site is located in an intergenic region between saeP and saeQ. This cleavage resulted in rapid degradation of the upstream fragment and stabilization of the downstream fragment...
April 27, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28453549/idiosyncratic-recognition-of-uug-uua-codons-by-modified-nucleoside-5-taurinomethyluridine-%C3%AF-m5u-present-at-wobble-position-in-anticodon-loop-of-trnaleu-a-molecular-modeling-approach
#7
Asmita S Kamble, Prayagraj M Fandilolu, Susmit B Sambhare, Kailas D Sonawane
Lack of naturally occurring modified nucleoside 5-taurinomethyluridine (τm5U) at the 'wobble' 34th position in tRNALeu causes mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). The τm5U34 specifically recognizes UUG and UUA codons. Structural consequences of τm5U34 to read cognate codons have not been studied so far in detail at the atomic level. Hence, 50ns multiple molecular dynamics (MD) simulations of various anticodon stem loop (ASL) models of tRNALeu in presence and absence of τm5U34 along with UUG and UUA codons were performed to explore the dynamic behaviour of τm5U34 during codon recognition process...
2017: PloS One
https://www.readbyqxmd.com/read/28453462/up-regulated-mir-221-expression-as-a-molecular-diagnostic-marker-in-laryngeal-squamous-cell-carcinoma-and-its-correlation-with-apaf-1-expression
#8
Samia Hussein, Hala Mosaad, Hayam E Rashed, Mohammad W El-Anwar
BACKGROUND: Despite the improvement in the diagnosis and the management of laryngeal squamous cell carcinoma (LSCC), many patients with advanced-stage have poor prognosis in the form of recurrence, metastasis or death. So, recognition of new molecular markers would facilitate the development of targeted therapies. OBJECTIVES: To investigate miR-221 expression in LSCC and its possible correlation to apoptotic protease activating factor-1 (Apaf-1). Also, we aimed to investigate the association between miR-221 and Apaf-1 expressions and the clinicopathological features of LSCC...
April 21, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28453304/mold-allergy-is-it-real-and-what-do-we-do-about-it
#9
Amanda Rudert, Jay Portnoy
Fungi produce substances that contain pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) which bind to pattern recognition receptors, stimulating innate immune responses in humans. They also produce allergens that induce production of specific IgE. Areas Covered: In this review we cover both innate and adaptive immune responses to fungi. Some fungal products can activate both innate and adaptive responses and in doing so, cause an intense and complex health effects...
April 28, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28449397/differential-proteome-profiling-in-the-hippocampus-of-amnesic-mice
#10
Meghraj Singh Baghel, Mahendra Kumar Thakur
Amnesia or memory loss is associated with brain aging and several neurodegenerative pathologies including Alzheimer's disease (AD). This can be induced by a cholinergic antagonist scopolamine, but the underlying molecular mechanism is poorly understood. The present study of proteome profiling in the hippocampus could provide conceptual insights into the molecular mechanisms involved in amnesia. To reveal this, mice were administered scopolamine to induce amnesia and memory impairment was validated by novel object recognition test...
April 27, 2017: Hippocampus
https://www.readbyqxmd.com/read/28449395/breast-milk-iga-to-foods-has-different-epitope-specificity-than-serum-iga-evidence-for-entero-mammary-link-for-food-specific-iga
#11
Antti E Seppo, Emma M Savilahti, M Cecilia Berin, Hugh A Sampson, Kirsi M Järvinen
BACKGROUND: We have previously shown that maternal cow's milk (CM) elimination results in down-regulation of CM-specific IgA antibody levels in BM, but not in serum, suggesting that an entero-mammary link may exist for food-specific antibody-secreting cells. OBJECTIVE: We sought to investigate whether food-specific IgA epitope profiles differ intra-individually between mother's serum and BM. We also examined how infants' food epitope-specific IgA develops in early infancy and the relationship of IgA epitope recognition with development of cow's milk allergy (CMA)...
April 27, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28449375/the-genetic-dimension-of-pest-pressure-in-the-tropical-rainforest
#12
Marco Todesco, Quentin Cronk
Wet tropical forests are among the most diverse ecosystems on Earth and can host several hundreds of tree species per hectare. To maintain such diversity, the community must contain large numbers of relatively rare species rather than be dominated by a few very common trees, as is often the case in temperate forests. Explaining the mechanisms preventing dominance by common species has been a major task of tropical forest ecology. One of the most promising mechanisms is negative density dependence (NDD) of tree abundance driven by pests, including fungal diseases ('pest pressure')...
May 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28449330/exploring-the-experience-of-nurse-practitioners-who-have-committed-medical-errors-a-phenomenological-approach
#13
Romuald Delacroix
BACKGROUND AND PURPOSE: To explore the experience of committing medical error from the perspective of nurse practitioners (NPs). Overall, the purpose of the study is to discern NPs' behaviors, perceptions, and coping mechanisms in response to having made a medical error. METHODS: Qualitative research based on two face-to-face audio-recorded semistructured interviews with 10 NPs who had made medical errors in practice. The analysis was guided by concepts in phenomenology...
April 27, 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28449246/review-article-hepatitis-e-a-concise-review-of-virology-epidemiology-clinical-presentation-and-therapy
#14
REVIEW
M C Donnelly, L Scobie, C L Crossan, H Dalton, P C Hayes, K J Simpson
BACKGROUND: Hepatitis E virus (HEV) is a leading cause of acute icteric hepatitis and acute liver failure in the developing world. During the last decade, there has been increasing recognition of autochthonous (locally acquired) HEV infection in developed countries. Chronic HEV infection is now recognised, and in transplant recipients this may lead to cirrhosis and organ failure. AIM: To detail current understanding of the molecular biology of HEV, diagnostic and therapeutic strategies and propose future directions for basic science and clinical research...
April 27, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28449098/insights-on-persistent-airway-infection-by-nontypeable-haemophilus-influenzae-in-chronic-obstructive-pulmonary-disease
#15
Christian P Ahearn, Mary C Gallo, Timothy F Murphy
Nontypeable Haemophilus influenzae (NTHi) is the most common bacterial cause of infection of the lower airways in adults with chronic obstructive pulmonary disease (COPD). Infection of the COPD airways causes acute exacerbations, resulting in substantial morbidity and mortality. NTHi has evolved multiple mechanisms to establish infection in the hostile environment of the COPD airways, allowing the pathogen to persist in the airways for months to years. Persistent infection of the COPD airways contributes to chronic airway inflammation that increases symptoms and accelerates the progressive loss of pulmonary function, which is a hallmark of the disease...
April 25, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28449072/functions-of-galectins-as-self-non-self-recognition-and-effector-factors
#16
Gerardo R Vasta, Chiguang Feng, Nuria González-Montalbán, Justin Mancini, Lishi Yang, Kelsey Abernathy, Graeme Frost, Cheyenne Palm
Carbohydrate structures on the cell surface encode complex information that through specific recognition by carbohydrate-binding proteins (lectins), modulates interactions between cells, cells and the extracellular matrix, or mediates recognition of potential microbial pathogens. Galectins are a family of ß-galactoside-binding lectins, which are evolutionary conserved and have been identified in most organisms, from fungi to invertebrates and vertebrates, including mammals. Since their discovery in the 1970s, their biological roles, initially understood as limited to recognition of endogenous carbohydrate ligands in embryogenesis and development, have expanded in recent years by the discovery of their roles in tissue repair and regulation of immune homeostasis...
April 25, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28449036/resting-connectivity-between-salience-nodes-predicts-recognition-memory
#17
Joseph M Andreano, Alexandra Touroutoglou, Bradford C Dickerson, Lisa Feldman Barrett
The resting connectivity of the brain's salience network, particularly the ventral subsystem of the salience network, has been previously associated with various measures of affective reactivity. Numerous studies have demonstrated that increased affective arousalleads to enhanced consolidation of memory. This suggests that individuals with greater ventral salience network connectivity will exhibit greater responses to affective experience, leading to a greater enhancement of memory by affect. To test this hypothesis, resting ventral salience connectivity was measured in 41 young adults, who were then exposed to neutral and negative affect inductions during a paired associate memory test...
April 25, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28448987/a-role-for-oxytocin-like-receptor-in-social-habituation-in-a-teleost
#18
Chelsea A Weitekamp, Tessa K Solomon-Lane, Pamela Del Valle, Zegni Triki, Bridget M Nugent, Hans A Hofmann
Oxytocin (OT) mediates social habituation in rodent model systems, but its role in mediating this effect in other vertebrates is unknown. We used males of the African cichlid fish, Astatotilapia burtoni, to investigate two aspects of isotocin (IT; an OT homolog) signaling in social habituation. First, we examined the expression of IT receptor 2 (ITR2) as well as two immediate early genes in brain regions implicated in social recognition. Next, we examined IT neuron activity using immunohistochemistry. Patterns of gene expression in homologs of the amygdala and hippocampus implicate IT signaling in these regions in social habituation to a territorial neighbor...
April 28, 2017: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/28448738/site-specific-recruitment-of-epigenetic-factors-with-a-modular-crispr-cas-system
#19
Tobias Anton, Sebastian Bultmann
Dissecting the complex network of epigenetic modifications requires tools that combine precise recognition of DNA sequences with the capability to modify epigenetic marks. The CRISPR/Cas system has been proven to be a valuable addition to existing methodologies that fulfill these tasks. So far, sequence-specific editing of epigenetic modifications such as DNA methylation and histone posttranslational modifications relied on direct fusions of enzymatically inactivated Cas9 (dCas9) with epigenetic effectors. Here, we report a novel, modular system that facilitates the recruitment of any GFP-tagged protein to desired genomic loci...
February 23, 2017: Nucleus
https://www.readbyqxmd.com/read/28448720/mosaic-neurofibromatosis-type-1-in-children-a-single-institution-experience
#20
Irene Lara-Corrales, Mitra Moazzami, Maria Teresa García-Romero, Elena Pope, Patricia Parkin, Andrea Shugar, Peter Kannu
BACKGROUND: Neurofibromatosis type 1 (NF1) is a neurocutaneous disorder caused by loss-of-function mutation in the NF1 gene. Segmental or mosaic NF1 (MNF) is an uncommon presentation of the NF1 result of postzygotic mutations that present with subtle localised clinical findings. OBJECTIVES: Our study's objectives were to describe the clinical characteristics of children with MNF. METHODS: We conducted a cross-sectional study of children diagnosed with MNF at the Hospital for Sick Children in Toronto, Canada, from January 1992 to September 2012...
April 1, 2017: Journal of Cutaneous Medicine and Surgery
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