Linfeng Li, Zhen Liu, Huiling Hu, Renming Cai, Jingdou Bi, Qin Wang, Xiaogang Zhou, Huairong Luo, Chun Zhang, Runlan Wan
Dendrobium nobile is a traditional Chinese herb with anti-inflammatory, antioxidant, and neuroprotective properties. However, its antiaging effects are unclear. Herein, we studied the aging-related functions and the mechanism of action of the alcohol extract of Dendrobium nobile (DnAE) in the model organism Caenorhabditis elegans . The results indicated that 1 mg/mL DnAE slowed lipofuscin accumulation, decreased the levels of reactive oxygen species, elevated superoxide dismutase activity, enhanced oxidative and heat stress resistance, extended the lifespan of nematodes, protected their dopamine neurons from 6-hydroxydopamine-induced neurodegeneration, and reduced Aβ-induced neurotoxicity...
February 19, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry