Di Lu, Xuanzhen Wu, Wendy Wu, Shuangxiu Wu, Hui Li, Yuhong Zhang, Xuebin Yan, Jianxue Zhai, Xiaoying Dong, Siyang Feng, Xueying Zhang, Fuming Sun, Shaobo Wang, Kaican Cai
Esophageal cancer is a highly incidence and deadly disease with a poor prognosis, especially in developing countries. Owing to the lack of specific symptoms and early diagnostic biomarkers, most patients are diagnosed with advanced disease, leading to a 5-year survival rate of less than 15%. Early (n = 50) and middle-advanced (n = 50) esophageal squamous cell carcinoma (ESCC) patients, as well as 71 healthy individuals, underwent 5-hydroxymethylcytosine (5hmC) sequencing on their plasma cell-free DNA (cfDNA)...
December 19, 2023: Cell Death & Disease