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https://www.readbyqxmd.com/read/28207831/the-relationship-between-rassf1a-gene-promoter-methylation-and-the-susceptibility-and-prognosis-of-melanoma-a-meta-analysis-and-bioinformatics
#1
Chihao Shao, Wenzhu Dai, Haili Li, Wenru Tang, Shuting Jia, Xiaoming Wu, Ying Luo
BACKGROUND: The function of the tumor suppressor gene RASSF1A in cancer cells has been detailed in many studies. However, due to the methylation of its promoter, the expression of RASSF1A is missing in most cancers. In the literature, we found that the conclusion regarding the relationship between RASSF1A gene promoter methylation and the susceptibility and prognosis of melanoma was not unified. This study adopts the use of a meta-analysis and bioinformatics to explore the relationship between RASSF1A gene promoter methylation and the susceptibility and prognosis of melanoma...
2017: PloS One
https://www.readbyqxmd.com/read/28207723/unhealthy-food-marketing-to-new-zealand-children-and-adolescents-through-the-internet
#2
Stefanie Vandevijvere, Karuna Sagar, Bridget Kelly, Boyd Swinburn
AIM: To assess the extent and nature of unhealthy food marketing to New Zealand children and adolescents through the internet. METHODS: Internet traffic data for January 2014 was purchased from AC Nielsen to identify the most popular websites (n=110) among children and adolescents aged 6-17 years. In addition, websites (n=70) of food and beverage brands most frequently marketed to children through television, sports, magazines and Facebook were included. Marketing techniques and features on those websites were analysed...
February 17, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28198670/metatopics-an-integration-tool-to-analyze-microbial-community-profile-by-topic-model
#3
Jifang Yan, Guohui Chuai, Tao Qi, Fangyang Shao, Chi Zhou, Chenyu Zhu, Jing Yang, Yifei Yu, Cong Shi, Ning Kang, Yuan He, Qi Liu
BACKGROUND: Deciphering taxonomical structures based on high dimensional sequencing data is still challenging in metagenomics study. Moreover, the common workflow processed in this field fails to identify microbial communities and their effect on a specific disease status. Even the relationships and interactions between different bacteria in a microbial community keep unknown. RESULTS: MetaTopics can efficiently extract the latent microbial communities which reflect the intrinsic relations or interactions among several major microbes...
January 25, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28196507/vrex-an-open-source-toolbox-for-creating-3d-virtual-reality-experiments
#4
Madis Vasser, Markus Kängsepp, Murad Magomedkerimov, Kälver Kilvits, Vladislav Stafinjak, Taavi Kivisik, Raul Vicente, Jaan Aru
BACKGROUND: We present VREX, a free open-source Unity toolbox for virtual reality research in the fields of experimental psychology and neuroscience. RESULTS: Different study protocols about perception, attention, cognition and memory can be constructed using the toolbox. VREX provides a procedural generation of (interconnected) rooms that can be automatically furnished with a click of a button. VREX includes a menu system for creating and storing experiments with different stages...
February 14, 2017: BMC Psychology
https://www.readbyqxmd.com/read/28187712/vmcmc-a-graphical-and-statistical-analysis-tool-for-markov-chain-monte-carlo-traces
#5
Raja H Ali, Mikael Bark, Jorge Miró, Sayyed A Muhammad, Joel Sjöstrand, Syed M Zubair, Raja M Abbas, Lars Arvestad
BACKGROUND: MCMC-based methods are important for Bayesian inference of phylogeny and related parameters. Although being computationally expensive, MCMC yields estimates of posterior distributions that are useful for estimating parameter values and are easy to use in subsequent analysis. There are, however, sometimes practical difficulties with MCMC, relating to convergence assessment and determining burn-in, especially in large-scale analyses. Currently, multiple software are required to perform, e...
February 10, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28165140/coffee-control-free-noninvasive-fetal-chromosomal-examination-using-maternal-plasma-dna
#6
Kun Sun, K C Allen Chan, Irena Hudecova, Rossa W K Chiu, Y M Dennis Lo, Peiyong Jiang
OBJECTIVE: The aim of this study is to develop an approach for analyzing plasma DNA sequencing data for noninvasive fetal chromosomal aneuploidy testing that does not require the comparison with control samples or a series of selected genomic regions. RESULTS: We developed the control-free noninvasive fetal chromosomal examination (COFFEE) algorithm by utilizing the size differences between the fetally derived and maternally derived DNA molecules in maternal plasma...
February 6, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28157824/label-free-imaging-of-female-genital-tract-melanocytic-lesions-with-pump-probe-microscopy-a-promising-diagnostic-tool
#7
Francisco E Robles, Sanghamitra Deb, Martin C Fischer, Warren S Warren, Maria Angelica Selim
OBJECTIVES: Melanomas of the female genital tract present a unique clinical challenge. Not only are these lesions in an anatomically sensitive area, but also they tend to be multifocal and have high recurrence rates. Furthermore, several benign melanocytic proliferations resemble early-stage melanoma clinically and/or histopathologically. Thus, there is a significant need for additional tools that can help correctly diagnose and stage these lesions. Here, we quantitatively and nondestructively analyze the chemical composition of melanin in excised pigmented lesions of the female genital tract using pump-probe microscopy, a high-resolution optical imaging technique that is sensitive to many biochemical properties of melanin...
February 3, 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28145990/computer-based-medical-education-in-benha-university-egypt-knowledge-attitude-limitations-and-suggestions
#8
Hanaa Bayomy, Mona El Awadi, Eman El Araby, Hala A Abed
BACKGROUND: Computer-assisted medical education has been developed to enhance learning and enable high-quality medical care. This study aimed to assess computer knowledge and attitude toward the inclusion of computers in medical education among second-year medical students in Benha Faculty of Medicine, Egypt, to identify limitations, and obtain suggestions for successful computer-based learning. PARTICIPANTS AND METHODS: This was a one-group pre-post-test study, which was carried out on second-year students in Benha Faculty of Medicine...
December 2016: Journal of the Egyptian Public Health Association
https://www.readbyqxmd.com/read/28130228/ligandbook-an-online-repository-for-small-and-drug-like-molecule-force-field-parameters
#9
Jan Domanski, Oliver Beckstein, Bogdan I Iorga
: Ligandbook is a public database and archive for force field parameters of small and drug-like molecules. It is a repository for parameter sets that are part of published work but are not easily available to the community otherwise. Parameter sets can be downloaded and immediately used in molecular dynamics simulations. The sets of parameters are versioned with full histories and carry unique identifiers to facilitate reproducible research. Text-based search on rich metadata and chemical substructure search allow precise identification of desired compounds or functional groups...
January 27, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28109252/rna-tvcurve-a-web-server-for-rna-secondary-structure-comparison-based-on-a-multi-scale-similarity-of-its-triple-vector-curve-representation
#10
Ying Li, Xiaohu Shi, Yanchun Liang, Juan Xie, Yu Zhang, Qin Ma
BACKGROUND: RNAs have been found to carry diverse functionalities in nature. Inferring the similarity between two given RNAs is a fundamental step to understand and interpret their functional relationship. The majority of functional RNAs show conserved secondary structures, rather than sequence conservation. Those algorithms relying on sequence-based features usually have limitations in their prediction performance. Hence, integrating RNA structure features is very critical for RNA analysis...
January 21, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28106709/systemic-pharmacokinetics-and-pharmacodynamics-of-intravitreal-aflibercept-bevacizumab-and-ranibizumab
#11
Robert L Avery, Alessandro A Castellarin, Nathan C Steinle, Dilsher S Dhoot, Dante J Pieramici, Robert See, Stephen Couvillion, Maʼan A Nasir, Melvin D Rabena, Mauricio Maia, Sherri Van Everen, Kha Le, William D Hanley
PURPOSE: To evaluate the systemic pharmacokinetics (PKs) of aflibercept, bevacizumab, and ranibizumab in patients with neovascular age-related macular degeneration (AMD), diabetic macular edema (DME), or retinal vein occlusion (RVO). METHODS: Prospective, open-label, nonrandomized clinical trial of patients with AMD, DME, or RVO who were antivascular endothelial growth factor (VEGF) naïve or had not received anti-VEGF for ≥4 months. Patients received 3 monthly intravitreal injections of aflibercept 2...
January 18, 2017: Retina
https://www.readbyqxmd.com/read/28100441/assessing-the-efficacy-of-an-app-based-method-of-family-planning-the-dot-study-protocol
#12
Rebecca G Simmons, Dominick C Shattuck, Victoria H Jennings
BACKGROUND: Some 222 million women worldwide have unmet needs for contraception; they want to avoid pregnancy, but are not using a contraceptive method, primarily because of concerns about side effects associated with most available methods. Expanding contraceptive options-particularly fertility awareness options that provide women with information about which days during their menstrual cycles they are likely to become pregnant if they have unprotected intercourse-has the potential to reduce unmet need...
January 18, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28079758/concussion-in-ice-hockey-current-gaps-and-future-directions-in-an-objective-diagnosis
#13
Aynsley M Smith, Michael J Stuart, William O Roberts, David W Dodick, Jonathan T Finnoff, Janelle K Jorgensen, David A Krause
OBJECTIVE: This review provides an update on sport-related concussion (SRC) in ice hockey and makes a case for changes in clinical concussion evaluation. Standard practice should require that concussions be objectively diagnosed and provide quantitative measures of the concussion injury that will serve as a platform for future evidence-based treatment. METHODS: The literature was surveyed to address several concussion-related topics: research in ice hockey-related head trauma, current subjective diagnosis, promising components of an objective diagnosis, and current and potential treatments...
January 10, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28060291/optimization-of-a-quantitative-micro-neutralization-assay
#14
Yipu Lin, Yan Gu, John W McCauley
The micro-neutralization (MN) assay is a standard technique for measuring the infectivity of the influenza virus and the inhibition of virus replication. In this study, we present the protocol of an imaging-based MN assay to quantify the true antigenic relationships between viruses. Unlike typical plaque reduction assays that rely on visible plaques, this assay quantitates the entire infected cell population of each well. The protocol matches the virus type or subtype with the selection of cell lines to achieve maximum infectivity, which enhances sample contrast during imaging and image processing...
December 14, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28049411/accelerating-metagenomic-read-classification-on-cuda-enabled-gpus
#15
Robin Kobus, Christian Hundt, André Müller, Bertil Schmidt
BACKGROUND: Metagenomic sequencing studies are becoming increasingly popular with prominent examples including the sequencing of human microbiomes and diverse environments. A fundamental computational problem in this context is read classification; i.e. the assignment of each read to a taxonomic label. Due to the large number of reads produced by modern high-throughput sequencing technologies and the rapidly increasing number of available reference genomes software tools for fast and accurate metagenomic read classification are urgently needed...
January 3, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28048381/su-f-p-41-iomp-new-professional-journal-medical-physics-international-initial-results
#16
S Tabakov, P Sprawls
PURPOSE: The number of professional and educational sessions and presentations at World Congresses (WC) doubled during the past 12 years. Alongside this, many new e-learning and related initiatives underpinned the global growth of medical physicists. A number of meetings discussed the need of an international forum to discuss medical physics education and professional development. In 2013 IOMP initiated a new Journal for the purpose - MEDICAL PHYSICS INTERNATIONAL (MPI) - a free access e-publication (www...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047651/su-f-j-100-standardized-biodistribution-template-for-nuclear-medicine-dosimetry-collection-and-reporting
#17
A Kesner, G Poli, S Beykan, M Lassman
PURPOSE: As the field of Nuclear Medicine moves forward with efforts to integrate radiation dosimetry into clinical practice we can identify the challenge posed by the lack of standardized dose calculation methods and protocols. All personalized internal dosimetry is derived by projecting biodistribution measurements into dosimetry calculations. In an effort to standardize organization of data and its reporting, we have developed, as a sequel to the EANM recommendation of "Good Dosimetry Reporting", a freely available biodistribution template, which can be used to create a common point of reference for dosimetry data...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047435/mo-de-bra-06-3d-image-acquisition-and-reconstruction-explained-with-online-animations
#18
A Kesner
PURPOSE: Understanding the principles of 3D imaging and image reconstruction is fundamental to the field of medical imaging. Clinicians, technologists, physicists, patients, students, and inquisitive minds all stand to benefit from greater comprehension of the supporting technologies. To help explain the basic principles of 3D imaging, we developed multi-frame animations that convey the concepts of tomographic imaging. The series of free (gif) animations are accessible online, and provide a multimedia introduction to the main concepts of image reconstruction...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27984423/evaluation-of-medication-mediated-effects-in-pharmacoepidemiology
#19
Eric J Tchetgen Tchetgen, Kelesitse Phiri
Medical conditions such as epilepsy or infection with human immunodeficiency virus (HIV) are known to be associated with a spectrum of adverse health outcomes if not appropriately managed by efficacious treatment and care. Medications for such conditions can be potent, and their use might sometimes have unintended health consequences. Prominent examples have emerged in HIV perinatal research in which use of antiretroviral treatment during pregnancy to treat maternal HIV infection and prevent transmission of the virus to the fetus have been shown to be associated with adverse birth outcomes...
December 12, 2016: Epidemiology
https://www.readbyqxmd.com/read/27973671/feasibility-of-obtaining-measures-of-lifestyle-from-a-smartphone-app-the-myheart-counts-cardiovascular-health-study
#20
Michael V McConnell, Anna Shcherbina, Aleksandra Pavlovic, Julian R Homburger, Rachel L Goldfeder, Daryl Waggot, Mildred K Cho, Mary E Rosenberger, William L Haskell, Jonathan Myers, Mary Ann Champagne, Emmanuel Mignot, Martin Landray, Lionel Tarassenko, Robert A Harrington, Alan C Yeung, Euan A Ashley
Importance: Studies have established the importance of physical activity and fitness, yet limited data exist on the associations between objective, real-world physical activity patterns, fitness, sleep, and cardiovascular health. Objectives: To assess the feasibility of obtaining measures of physical activity, fitness, and sleep from smartphones and to gain insights into activity patterns associated with life satisfaction and self-reported disease. Design, Setting, and Participants: The MyHeart Counts smartphone app was made available in March 2015, and prospective participants downloaded the free app between March and October 2015...
January 1, 2017: JAMA Cardiology
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