keyword
MENU ▼
Read by QxMD icon Read
search

free download

keyword
https://www.readbyqxmd.com/read/28714760/houston-we-still-have-a-problem
#1
Martin Buchheit
Apollo 13 was initially looking like it would be the smoothest flight ever. After the explosion of an oxygen tank however, the astronauts were close to spending the rest of their lives in rotation around the planet. I wished to use this well-known incident to discuss further the link, or lack thereof, between sport sciences research and current field practices. There is a feeling that the academic culture and its publishing requirements have created a bit of an Apollo 13-like orbiting world (e.g., journals and conferences) that is mostly disconnected from the reality of elite performance...
July 17, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28697053/postoperative-adjuvant-therapy-for-resectable-pancreatic-cancer-with-gemcitabine-and-adoptive-immunotherapy
#2
Hiroto Matsui, Shoichi Hazama, Kazuhiko Sakamoto, Yoshitaro Shindo, Shinsuke Kanekiyo, Masao Nakashima, Satoshi Matsukuma, Yoshihiro Tokuhisa, Michihisa Iida, Nobuaki Suzuki, Kiyoshi Yoshimura, Shigeru Takeda, Tomio Ueno, Shigefumi Yoshino, Masaaki Oka, Hiroaki Nagano
OBJECTIVES: We previously described adoptive immunotherapy (AIT) with cytotoxic T lymphocytes (CTLs) stimulated by the mucin 1 (MUC1)-expressing human pancreatic cancer cell line YPK-1 (MUC1-CTLs) and demonstrated that MUC1-CTLs might prevent liver metastasis. In the present study, we combined gemcitabine (GEM) and AIT for the treatment of pancreatic cancer. METHODS: A total of 43 patients who underwent radical pancreatectomy received treatment with MUC1-CTLs and GEM...
July 11, 2017: Pancreas
https://www.readbyqxmd.com/read/28695803/bioinformatic-analysis-of-differentially-expressed-genes-in-peripheral-blood-of-human-immunodeficiency-virus-tubercle-bacilli-co-infected-patients
#3
Rongqiang Zhang, Qiling Liu, Na Sun, Wulin Kang, Puwei Yuan
Objective To analyze the differentially expressed genes in peripheral blood of human immunodeficiency(HIV)/tubercle bacilli co-infected patients and explore the biological regulatory mechanism and network of key proteins,so as to provide new evidence for early diagnosis and clinical treatment of HIV/TB co-infected patients. Methods Microarray gene chip data of HIV/TB co-infected patients were downloaded from public databases GEO and imported into the analysis software GEO,STRING,PANTHER,and GenClip. The gene expression profiles,protein interaction networks,processes of molecular biology,and gene functions were analyzed...
June 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28683005/the-use-of-endometrial-cancer-patient-derived-organoid-culture-for-drug-sensitivity-testing-is-feasible
#4
Eugenia Girda, Eric C Huang, Gary S Leiserowitz, Lloyd H Smith
OBJECTIVE: Patient-derived organoids (PDOs), used in multiple tumor types, have allowed evaluation of tumor characteristics from individual patients. This study aimed to assess the feasibility of applying PDO in vitro culture for endocrine-based and drug sensitivity testing in endometrial cancer. METHODS: Endometrial cancer cells were enzymatically dissociated from tumors retrieved from fresh hysterectomy specimens and cultured within basement membrane extract in serum-free medium...
July 5, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28682834/high-expression-of-yes-activated-protein-1-in-papillary-thyroid-carcinoma-correlates-with-poor-prognosis
#5
Zeming Liu, Wen Zeng, Yusufu Maimaiti, Jie Ming, Yawen Guo, Yan Liu, Chunping Liu, Tao Huang
CONTEXT: The Hippo signal transduction pathway is highly conserved in mammals. It plays a critical role in tissue and organ size by regulating the balance between cell proliferation and apoptosis. However, there have been few reports concerning Yes-activated protein-1 (YAP-1) elevation in papillary thyroid cancer (PTC). OBJECTIVE: The objective of this study was to determine whether YAP-1 expression is a biomarker and high-risk clinicopathologic prognosticator in PTC...
July 4, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28678321/pde3a-is-hypermethylated-in-cisplatin-resistant-non-small-cell-lung-cancer-cells-and-is-a-modulator-of-chemotherapy-response
#6
F-M Tian, C-Y Zhong, X-N Wang, Y Meng
OBJECTIVE: In this study, we aimed to investigate the mechanism of PDE3A downregulation in chemoresistant non-small cell lung cancer (NSCLC) cells, its functional role in chemotherapy response and association with survival outcomes. MATERIALS AND METHODS: The raw data of GDS5247 was downloaded from GEO datasets and reanalyzed. The expression of PDE3A in patients with NSCLC and its DNA methylation status were analyzed in NSCLC cohort in TCGA database. Cisplatin resistant A549/Cis cells and the parental A549 cells were used as the in vitro cell model...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28670277/nano-lazar-read-across-predictions-for-nanoparticle-toxicities-with-calculated-and-measured-properties
#7
Christoph Helma, Micha Rautenberg, Denis Gebele
The lazar framework for read across predictions was expanded for the prediction of nanoparticle toxicities, and a new methodology for calculating nanoparticle descriptors from core and coating structures was implemented. Nano-lazar provides a flexible and reproducible framework for downloading data and ontologies from the open eNanoMapper infrastructure, developing and validating nanoparticle read across models, open-source code and a free graphical interface for nanoparticle read-across predictions. In this study we compare different nanoparticle descriptor sets and local regression algorithms...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28667915/knockdown-of-tnf-receptor-associated-factor-2-traf2-modulates-in-vitro-growth-of-trail-treated-prostate-cancer-cells
#8
Bingbing Wei, Jun Ruan, Yuanyuan Mi, Jimeng Hu, Jian Zhang, Zhirong Wang, Qiang Hu, Haowen Jiang, Qiang Ding
TNF receptor-associated factor 2 (TRAF2) is documented to regulate tumor development and progression. Currently, the effect of TRAF2 on growth of androgen-refractory prostate cancer in response to TRAIL and the molecular mechanisms are not well understood. Here, we aim to investigate the effect of TRAF2 on in vitro growth of human androgen-insensitive prostate cancer DU-145 cells in the presence of TRAIL. Bioinformatics analysis of the Cancer Genome Atlas (TCGA) data was performed to examine TRAF2 expression and the prognostic value in prostate cancer...
June 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28666387/toolkit-for-the-construction-of-reproducing-kernel-based-representations-of-data-application-to-multidimensional-potential-energy-surfaces
#9
Oliver T Unke, Markus Meuwly
In the early days of computation, slow processor speeds limited the amount of data that could be generated and used for scientific purposes. In the age of big data, the limiting factor usually is the method with which large amounts of data are analyzed and useful information is extracted. A typical example from chemistry are high-level ab initio calculations for small systems, which have nowadays become feasible even if energies at many different geometries are required. Molecular dynamics simulations often require several thousand distinct trajectories to be run...
July 17, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28658020/socially-accountable-medical-education-an-innovative-approach-at-florida-international-university-herbert-wertheim-college-of-medicine
#10
Pedro J Greer, David R Brown, Luther G Brewster, Onelia G Lage, Karin F Esposito, Ebony B Whisenant, Frederick W Anderson, Natalie K Castellanos, Troy A Stefano, John A Rock
PROBLEM: Despite medical advances, health disparities persist, resulting in medicine's renewed emphasis on the social determinants of health and calls for reform in medical education. APPROACH: The Green Family Foundation Neighborhood Health Education Learning Program (NeighborhoodHELP) at Herbert Wertheim College of Medicine provides a platform for the school's community-focused mission. NeighborhoodHELP emphasizes social accountability and interprofessional education while providing evidence-based, patient- and household-centered care...
June 27, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28653889/bioinformatics-methods-for-identifying-differentially-expressed-genes-and-signaling-pathways-in-nano-silica-stimulated-macrophages
#11
Lin Zhang, Changfu Hao, Juan Li, Yaqian Qu, Lei Bao, Yiping Li, Zhongzheng Yue, Miao Zhang, Xinghao Yu, Huiting Chen, Jianhui Zhang, Di Wang, Wu Yao
The incidence of disease relating to nanoparticle exposure has been rising rapidly in recent years, for which there is no effective treatment. Macrophage is suggested to play a crucial role in the development of pulmonary disease. To investigate the changes in macrophage after being stimulated by nanometer silica dust and to explore potential biomarkers and signaling pathways, the gene chip GSE13005 was downloaded from Gene Expression Omnibus database, which contained 21 samples: 3 samples per group and 7 groups in total...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28634724/darma-software-for-dual-axis-rating-and-media-annotation
#12
Jeffrey M Girard, Aidan G C Wright
Continuous measurement systems provide a means of measuring dynamic behavioral and experiential processes as they play out over time. DARMA is a modernized continuous measurement system that synchronizes media playback and the continuous recording of two-dimensional measurements. These measurements can be observational or self-reported and are provided in real-time through the manipulation of a computer joystick. DARMA also provides tools for reviewing and comparing collected measurements and for customizing various settings...
June 20, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28634004/minyoo-matata-the-vicious-worm-a-taenia-solium-computer-based-health-education-tool-in-swahili
#13
Chiara Trevisan, Eric M Fèvre, Maurice Owiny, Isaac Ngere, Maria Vang Johansen
Lack of knowledge is one of the main risk factors for the spread of the zoonotic parasite Taenia solium. The computer-based health-education tool 'The Vicious Worm' was developed to create awareness and provide evidence-based health education as a specific measure in control strategies. To increase the reach of the tool, a new version in Swahili was developed and can now be downloaded for free from http://theviciousworm.sites.ku.dk.
June 17, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28627465/differential-proteome-analysis-of-hippocampus-and-temporal-cortex-using-label-free-based-2d-lc-ms-ms
#14
Xiaoyan Liu, Zhengguang Guo, Wei Liu, Wei Sun, Chao Ma
Hippocampus and temporal cortex are important brain regions, which play distinct, but complimentary roles in mediating learning and memory. Herein, we utilized label-free differential proteome strategy to explore function of normal human hippocampus and temporal cortex in learning and memory. As a result, a total of 5529 and 5702 proteins were identified in hippocampus and temporal cortex, respectively, 516 of which were significantly differential expressed, with abundance span 5 orders of magnitudes. Pathways analysis showed that temporal cortex was involved in growth of axons growth and synapse density regulation, through which could regulate long-term potentiation and long-term retention of trace memory...
June 13, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28622818/use-of-a-smartphone-application-to-screen-for-depression-and-suicide-in-south-korea
#15
Seung-Ho Jang, Young Sup Woo, Jeong-Wan Hong, Bo-Hyun Yoon, Tae-Yeon Hwang, Moon-Doo Kim, Sang-Yeol Lee, Won-Myong Bahk
OBJECTIVE: This is a cross-sectional study using a free depression and suicide screening smartphone application, which contains the data from the Center for Epidemiological Studies-Depression (CES-D) and a Suicide Behaviors Questionnaire-Revised (SBQ-R). METHOD: The free application was downloaded worldwide from Apple's App Store and Android Market, and the participants who downloaded the application were actively measured. RESULTS: The subjects totaled 208,683 men and women...
May 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28619296/understanding-north-american-yoga-therapists-attitudes-skills-and-use-of-evidence-based-practice-a-cross-national-survey
#16
Marlysa Sullivan, Matthew Leach, James Snow, Steffany Moonaz
INTRODUCTION: Little is known about the adoption of evidence-based practice (EBP) by yoga therapists (YTs). OBJECTIVE: To determine the attitudes, skills, training, use, barriers and facilitators to the use of EBP amongst North American YTs DESIGN: Cross-sectional, descriptive survey METHODS: Self-identified YTs practicing in North America were invited to participate in an online survey. YT attitudes, skills, training, utilisation, barriers to use, and facilitators of EBP use were measured using the 84-item Evidence-Based practice Attitude and utilization SurvEy (EBASE)...
June 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28613845/spatial-and-temporal-trends-in-global-emissions-of-nitrogen-oxides-from-1960-to-2014
#17
Tianbo Huang, Xi Zhu, Qirui Zhong, Xiao Yun, Wenjun Meng, Bengang Li, Jianmin Ma, Eddy Y Zeng, Shu Tao
The quantification of nitrogen oxide (NOx) emissions is critical for air quality modeling. Based on updated fuel consumption and emission factor databases, a global emission inventory was compiled with high spatial (0.1° × 0.1°), temporal (monthly), and source (87 sources) resolutions for the period 1960 to 2014. The monthly emission data have been uploaded online ( http://inventory.pku.edu.cn ), along with a number of other air pollutant and greenhouse gas data for free download. Differences in source profiles, not global total quantities, between our results and those reported previously were found...
June 29, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28585144/weighted-gene-co-expression-network-analysis-of-gene-modules-for-the-prognosis-of-esophageal-cancer
#18
Cong Zhang, Qian Sun
Esophageal cancer is a common malignant tumor, whose pathogenesis and prognosis factors are not fully understood. This study aimed to discover the gene clusters that have similar functions and can be used to predict the prognosis of esophageal cancer. The matched microarray and RNA sequencing data of 185 patients with esophageal cancer were downloaded from The Cancer Genome Atlas (TCGA), and gene co-expression networks were built without distinguishing between squamous carcinoma and adenocarcinoma. The result showed that 12 modules were associated with one or more survival data such as recurrence status, recurrence time, vital status or vital time...
June 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28581279/improved-software-to-browse-the-serial-medical-images-for-learning
#19
Koojoo Kwon, Min Suk Chung, Jin Seo Park, Byeong Seok Shin, Beom Sun Chung
The thousands of serial images used for medical pedagogy cannot be included in a printed book; they also cannot be efficiently handled by ordinary image viewer software. The purpose of this study was to provide browsing software to grasp serial medical images efficiently. The primary function of the newly programmed software was to select images using 3 types of interfaces: buttons or a horizontal scroll bar, a vertical scroll bar, and a checkbox. The secondary function was to show the names of the structures that had been outlined on the images...
July 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28559222/mobile-app-design-development-and-publication-for-adverse-drug-reaction-assessments-of-causality-severity-and-preventability
#20
Muslimah Ithnin, Mohd Dzulkhairi Mohd Rani, Zuraidah Abd Latif, Paveethra Kani, Asmalita Syaiful, Khairun Nain Nor Aripin, Tengku Amatullah Madeehah Tengku Mohd
BACKGROUND: Adverse drug reactions (ADRs) cause significant morbidity and mortality. Improved assessment of ADRs to identify the causal relationship, the severity, and the preventability will aid ADRs prevention or reduce patient burden. OBJECTIVE: The aim of this study was to develop mobile apps in assisting clinical decision in ADR assessments of causality, severity, and preventability using validated tools. The usability of the apps was assessed. METHODS: We designed mobile apps using validated assessment tools for ADRs...
May 30, 2017: JMIR MHealth and UHealth
keyword
keyword
106140
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"