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Amit M Oza, Frédéric Selle, Irina Davidenko, Jacob Korach, Cesar Mendiola, Patricia Pautier, Ewa Chmielowska, Aristotelis Bamias, Andrea DeCensi, Zanete Zvirbule, Antonio González-Martín, Roberto Hegg, Florence Joly, Claudio Zamagni, Angiolo Gadducci, Nicolas Martin, Stephen Robb, Nicoletta Colombo
OBJECTIVE: The aim of this study was to assess the safety and efficacy of extending bevacizumab therapy beyond 15 months in nonprogressive ovarian cancer. PATIENTS AND METHODS: In this multinational prospective single-arm study ( NCT01239732), eligible patients had International Federation of Gynecology and Obstetrics stage IIB to IV or grade 3 stage I to IIA ovarian cancer without clinical signs or symptoms of gastrointestinal obstruction or history of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within the preceding 6 months...
October 4, 2016: International Journal of Gynecological Cancer
Christian Keinki, Richard Zowalla, Martin Wiesner, Marie Jolin Koester, Jutta Huebner
The improvement of health literacy in general and the information of individual patient is a major concern of the German national cancer plan and similar initiatives in other western countries. The aim of our study was to assess the readability and understandability of information booklets for cancer patients available at German Web sites. A support vector machine (SVM) was used to discriminate between laymen- and expert-centric patient information booklets about nine most common tumor types. All booklets had to be available for free at the Internet...
October 10, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
Marcin Frączek, Mateusz Kolator, Tomasz Kręcicki
: Indroduction: The planning of the course of surgery in patients with paranasal sinus disorders requires the meticulous evaluation of computed tomography (CT) scans. However, ENT doctors still often receive unsatisfactory DICOM images, which require multiplanar reconstruction (MPR). THE AIM: The objective of the present study was to evaluate and test DICOM viewers with MPR function currently available on the Internet for free. MATERIAL AND METHODS: Detailed Internet searches and analysis of databases were carried out to find the maximum number of browsers...
2016: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
E A Edwards, J Lumsden, C Rivas, L Steed, L A Edwards, A Thiyagarajan, R Sohanpal, H Caton, C J Griffiths, M R Munafò, S Taylor, R T Walton
OBJECTIVE: Smartphone games that aim to alter health behaviours are common, but there is uncertainty about how to achieve this. We systematically reviewed health apps containing gaming elements analysing their embedded behaviour change techniques. METHODS: Two trained researchers independently coded apps for behaviour change techniques using a standard taxonomy. We explored associations with user ratings and price. DATA SOURCES: We screened the National Health Service (NHS) Health Apps Library and all top-rated medical, health and wellness and health and fitness apps (defined by Apple and Google Play stores based on revenue and downloads)...
October 4, 2016: BMJ Open
Saulo Henrique Pires de Oliveira, Jiye Shi, Charlotte M Deane
MOTIVATION: Co-evolution methods have been used as contact predictors to identify pairs of residues that share spatial proximity. Such contact predictors have been compared in terms of the precision of their predictions, but there is no study that compares their usefulness to model generation. RESULTS: We compared eight different co-evolution methods for a set of ~3,500 proteins and found that metaPSICOV stage 2 produces, on average, the most precise predictions...
September 27, 2016: Bioinformatics
Marie-France Coutu, Valérie Albert, Marie-Elise Labrecque
OBJECTIVE/INTRODUCTION: The Revised Illness Perception Questionnaire adapted for Work Disability (IPQR-WD) is an adaptation of Illness Perception Questionnaire-Revised: the most used and most comprehensive tool for measuring illness perceptions. Evaluating representations is crucial, since it is a main determinant of return to work in cases of persistent pain due to musculoskeletal disorders. OBJECTIVE: This study aim at facilitating systematic assessment of work disability representations by assessing the usability of the Web platform and the usefulness of automatic interpretation of the results...
September 2016: Annals of Physical and Rehabilitation Medicine
Zhen Liu, Yangzi Tian, Guanghui Xu, Shushang Liu, Man Guo, Xiao Lian, Daiming Fan, Hongwei Zhang, Fan Feng
GOALS: The present study aimed to investigate the clinicopathologic features and prognosis of pancreatic gastrointestinal stromal tumor (GIST). BACKGROUND: Reports on clinicopathologic features and prognosis of pancreatic GIST are limited due to the extremely rare incidence. STUDY: One case of pancreatic GIST from our center and 44 cases reported in MEDLINE were enrolled in this study. Clinicopathologic features and prognosis of pancreatic GISTs were analyzed and compared with 297 gastric GISTs from our center...
September 26, 2016: Journal of Clinical Gastroenterology
John Shiguang Loy, Eskinder Eshetu Ali, Kevin Yi-Lwern Yap
BACKGROUND: The advent of smartphones has enabled a plethora of medical apps for disease management. As of 2012, there are 40,000 health care-related mobile apps available in the market. Since most of these medical apps do not go through any stringent quality assessment, there is a risk of consumers being misinformed or misled by unreliable information. In this regard, apps that target medication-related problems (MRPs) are not an exception. There is little information on what constitutes quality in apps that target MRPs and how good the existing apps are...
October 2016: Journal of Managed Care & Specialty Pharmacy
Pawel Piatkowski, Joanna M Kasprzak, Deepak Kumar, Marcin Magnus, Grzegorz Chojnowski, Janusz M Bujnicki
RNA encompasses an essential part of all known forms of life. The functions of many RNA molecules are dependent on their ability to form complex three-dimensional (3D) structures. However, experimental determination of RNA 3D structures is laborious and challenging, and therefore, the majority of known RNAs remain structurally uncharacterized. To address this problem, computational structure prediction methods were developed that either utilize information derived from known structures of other RNA molecules (by way of template-based modeling) or attempt to simulate the physical process of RNA structure formation (by way of template-free modeling)...
2016: Methods in Molecular Biology
Florian J Gisdon, Martin Culka, G Matthias Ullmann
Conjugate peak refinement (CPR) is a powerful and robust method to search transition states on a molecular potential energy surface. Nevertheless, the method was to the best of our knowledge so far only implemented in CHARMM. In this paper, we present PyCPR, a new Python-based implementation of the CPR algorithm within the pDynamo framework. We provide a detailed description of the theory underlying our implementation and discuss the different parts of the implementation. The method is applied to two different problems...
October 2016: Journal of Molecular Modeling
D Sam Paul, N Gautham
We previously developed an algorithm to perform conformational searches of proteins and peptides, and to perform the docking of ligands to protein receptors. In order to identify optimal conformations and docked poses, this algorithm uses mutually orthogonal Latin squares (MOLS) to rationally sample the vast conformational (or docking) space, and then analyzes this relatively small sample using a variant of mean field theory. The conformational search part of the algorithm was denoted MOLS 1.0. The docking portion of the algorithm, which allows only "flexible ligand/rigid receptor" docking, was denoted MOLSDOCK...
October 2016: Journal of Molecular Modeling
Tao Zhu, Wen Gao, Xi Chen, Ying Zhang, Meijuan Wu, Ping Zhang, Shihua Wang
OBJECTIVE: Early diagnosis of epithelial ovarian cancer is critical for patient survival. The objective of this pilot study is to identify a circulating micro (mi)RNA as a potential biomarker for epithelial ovarian cancer. METHODS: A total of 135 epithelial ovarian cancer patients and 54 benign ovarian tumor patients were recruited for this study. Using customized TaqMan low density miRNA arrays, we first screened expression levels of 48 miRNAs in sera from 18 epithelial ovarian cancer patients and 16 benign ovarian tumor patients...
September 15, 2016: International Journal of Gynecological Cancer
G W Griffiths, Ł Płociniczak, W E Schiesser
We discuss the solution of cornea curvature using a meshless method based on radial basis functions (RBFs). A full two-dimensional nonlinear thin membrane partial differential equation (PDE) model is introduced and solved using the multiquadratic (MQ) and inverse multiquadratic (IMQ) RBFs. This new approach does not rely on radial symmetry or other simplifying assumptions in respect of the cornea shape. It also provides an alternative to corneal topography modeling methods requiring accurate material parameter values, such as Young's modulus and Poisson ratio, that may not be available...
October 1, 2016: Computers in Biology and Medicine
Juliano Lara Fernandes, Luciana Andrea Barozi Fioravante, Monica P Verissimo, Sandra R Loggetto
BACKGROUND: Iron overload assessment with magnetic resonance imaging (MRI) using T2* has become a key diagnostic method in the management of many diseases. Quantitative analysis of the MRI images with a cost-effective tool has been a limitation to increased use of the method. PURPOSE: To provide a free software solution for this purpose comparing the results with a commercial solution. MATERIAL AND METHODS: The free tool was developed as a standalone program to be directly downloaded and ran in a common personal computer platform without the need of a dedicated workstation...
September 10, 2016: Acta Radiologica
Launette Marie Rieb, Wendy V Norman, Ruth Elwood Martin, Jonathan Berkowitz, Evan Wood, Ryan McNeil, M-J Milloy
Withdrawal pain can be a barrier to opioid cessation. Yet, little is known about old injury site pain in this context. We conducted an exploratory mixed-methods descriptive case series using a web-based survey and in-person interviews with adults recruited from pain and addiction treatment and research settings. We included individuals who self-reported a past significant injury that was healed and pain-free prior to the initiation of opioids, which then became temporarily painful upon opioid cessation - a phenomenon we have named withdrawal-associated injury site pain (WISP)...
September 1, 2016: Pain
Leonardo Kapural, Cong Yu, Matthew W Doust, Bradford E Gliner, Ricardo Vallejo, B Todd Sitzman, Kasra Amirdelfan, Donna M Morgan, Thomas L Yearwood, Richard Bundschu, Thomas Yang, Ramsin Benyamin, Abram H Burgher
BACKGROUND: Pain relief with spinal cord stimulation (SCS) has focused historically on paresthesias overlapping chronically painful areas. A higher level evidence supports the use of SCS in treating leg pain than supports back pain, as it is difficult to achieve adequate paresthesia coverage, and then pain relief, in the low back region. In comparison, 10-kHz high-frequency (HF10) SCS therapy does not rely on intraoperative paresthesia mapping and remains paresthesia-free during therapy...
September 6, 2016: Neurosurgery
Sijia Wu, Xinman Zhang, Jiuqiang Han
RNase H (RNH) is a pivotal domain in retrovirus to cleave the DNA-RNA hybrid for continuing retroviral replication. The crucial role indicates that RNH is a promising drug target for therapeutic intervention. However, annotated RNHs in UniProtKB database have still been insufficient for a good understanding of their statistical characteristics so far. In this work, a computational RNH model was proposed to annotate new putative RNHs (np-RNHs) in the retroviruses. It basically predicts RNH domains through recognizing their start and end sites separately with SVM method...
2016: PloS One
Jeffrey Hsu, Di Liu, Ya Min Yu, Hui Tong Zhao, Zhi Rou Chen, Jiao Li, Wei Chen
BACKGROUND: China's mHealth market is on track to become a global leader by industry size. The Chinese mobile app market and health care system have peculiarities that distinguish them from other app markets. To date, Chinese mHealth apps have not been systematically investigated. OBJECTIVE: The objective of this study was to provide an overview of Chinese mHealth apps as of December 2015. METHODS: We identified and investigated the most downloaded apps from the iOS and Android platforms...
August 29, 2016: Journal of Medical Internet Research
Zachary E Brewer, William David Ogden, James I Fann, Thomas A Burdon, Ahmad Y Sheikh
Several modern learning frameworks (eg, cognitive apprenticeship, anchored instruction, and situated cognition) posit the utility of nontraditional methods for effective experiential learning. Thus, development of novel educational tools emphasizing the cognitive framework of operative sequences may be of benefit to surgical trainees. We propose the development and global deployment of an effective, mobile cognitive cardiac surgical simulator. In methods, 16 preclinical medical students were assessed. Overall, 4 separate surgical modules (sternotomy, cannulation, decannulation, and sternal closure) were created utilizing the Touch Surgery (London, UK) platform...
2016: Seminars in Thoracic and Cardiovascular Surgery
S Piotto, L Di Biasi, R Fino, R Parisi, L Sessa, S Concilio
Molecular docking is a computational method employed to estimate the binding between a small ligand (the drug candidate) and a protein receptor that has become a standard part of workflow in drug discovery. Generally, when the binding site is known and a molecule is similar to known ligands, the most popular docking methods are rather accurate in the prediction of the geometry. Unfortunately, when the binding site is unknown, the blind docking analysis requires large computational resources and the results are often not accurate...
August 26, 2016: Journal of Computer-aided Molecular Design
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