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https://www.readbyqxmd.com/read/29771811/use-of-emergency-manuals-during-actual-critical-events-in-china-a-multi-institutional-study
#1
Jeffrey Huang, Jiayan Wu, Christina Dai, Xianwei Zhang, Hui Ju, Yiqi Chen, Chunyuan Zhang, Fan Ye, Yi Tan, Yongbo Zong, Telong Liu
INTRODUCTION: Emergency manuals (EMs) can help healthcare providers respond to crises more efficiently. Three anesthesia EMs have been translated into Chinese. These EMs have been made publicly available as a free document downloadable in China. A year after these Chinese versions of EMs were published, we conducted a multi-institutional survey in China to assess the progress of how well EM had been adapted and used in the setting of critical events. METHODS: Our study used a multi-institutional, anonymous electronic survey...
May 16, 2018: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/29771718/evaluation-of-drug-effects-on-cerebral-blood-flow-and-glucose-uptake-in-un-anesthetized-and-un-stimulated-rats-application-of-free-moving-apparatus-enabling-to-keep-rats-free-during-pet-spect-tracer-injection-and-uptake
#2
Taku Sugita, Yusuke Kondo, Seigo Ishino, Ikuo Mori, Takashi Horiguchi, Mikako Ogawa, Yasuhiro Magata
OBJECTIVES: The purpose of this study is the development of novel fluorine-18-fluorodeoxyglucose (F-FDG)-PET and Tc-hexamethylpropylene amine oxime (HMPAO) SPECT methods with free-moving apparatus on conscious rats to investigate brain activity without the effects of anesthesia and tactual stimulation. We also assessed the sensitivity of the experimental system by an intervention study using fluoxetine as a reference drug. MATERIALS AND METHODS: A catheter was inserted into the femoral vein and connected to a free-moving cannula system...
May 15, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29763731/interactive-web-based-identification-and-visualization-of-transcript-shared-sequences
#3
Alaleh Azhir, Louis-Henri Merino, David Nauen
We have developed TraC (Transcript Consensus), a web-based tool for detecting and visualizing shared sequences among two or more mRNA transcripts such as splice variants. Results including exon-exon boundaries are returned in a highly intuitive, data-rich, interactive plot that permits users to explore the similarities and differences of multiple transcript sequences. The online tool (http://labs.pathology.jhu.edu/nauen/trac/) is free to use. The source code is freely available for download (https://github...
May 12, 2018: Genomics
https://www.readbyqxmd.com/read/29750323/the-updated-ajcc-tnm-staging-system-for-papillary-thyroid-cancer-8th-edition-from-the-perspective-of-genomic-analysis
#4
Kyubo Kim, Jin Hwan Kim, Il Seok Park, Young Soo Rho, Gee Hwan Kwon, Dong Jin Lee
BACKGROUND: Recently, the American Joint Committee on Cancer published the 8th edition of its Cancer Staging Manual with major changes regarding the staging of thyroid cancer, including the raising of the age cutoff from 45 to 55 years. Using the clinical and genetic data of 505 papillary thyroid cancer (PTC) cases, we aimed to compare overall survival (OS) and recurrence-free survival (RFS) with different age cutoff values, and also investigate the efficacy of the new staging system on a genomic level...
May 10, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29746394/pharmacokinetics-of-doripenem-in-healthy-koreans-and-monte-carlo-simulations-to-explore-optimal-dosage-regimens-in-patients-with-normal-and-enhanced-renal-function
#5
So Won Kim, Sangmin Choe, Dong Jin Kim, Dae Young Zang, Dong-Hwan Lee
BACKGROUND: Dose adjustment is often required in patients with normal or enhanced renal function. The aim of this study is to investigate the pharmacokinetic (PK) properties of doripenem and explore optimal dosing regimens in patients with normal or enhanced renal function according to various minimum inhibitory concentrations (MIC). METHODS: The authors conducted a clinical trial and analyzed PK samples in 11 healthy Korean subjects applying non-compartmental analysis (NCA) and a population approach...
May 9, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29741583/lzw-kernel-fast-kernel-utilizing-variable-length-code-blocks-from-lzw-compressors-for-protein-sequence-classification
#6
Gleb Filatov, Bruno Bauwens, Attila Kertész-Farkas
Motivation: Bioinformatics studies often rely on similarity measures between sequence pairs, which often pose a bottleneck in large-scale sequence analysis. Results: Here, we present a new convolutional kernel function for protein sequences called the LZW-Kernel. It is based on code words identified with the Lempel-Ziv-Welch (LZW) universal text compressor. The LZW-Kernel is an alignment-free method, it is always symmetric, is positive, always provides 1.0 for self-similarity and it can directly be used with Support Vector Machines (SVMs) in classification problems, contrary to normalized compression distance (NCD), which often violates the distance metric properties in practice and requires further techniques to be used with SVMs...
May 7, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29736848/the-most-downloaded-and-most-cited-articles-in-radiology-journals-a-comparative-bibliometric-analysis
#7
Sora Baek, Dae Young Yoon, Kyoung Ja Lim, Young Kwon Cho, Young Lan Seo, Eun Joo Yun
OBJECTIVES: To evaluate and compare the characteristics of the most downloaded and most cited articles in radiology journals. METHODS: We selected 41 radiology journals that provided lists of both the most downloaded and most cited articles on their websites, and identified the 596 most downloaded articles and 596 most cited articles. We compared the following characteristics of the most downloaded and most cited articles: year of publication, journal title, department of the first author, country of origin, publication type, radiologic subspecialty, radiologic technique and accessibility...
May 7, 2018: European Radiology
https://www.readbyqxmd.com/read/29728343/determinants-of-intention-to-use-mobile-phone-caller-tunes-to-promote-voluntary-blood-donation-cross-sectional-study
#8
Bernard Appiah, James N Burdine, Ammar Aftab, Lucy Asamoah-Akuoko, David A Anum, Irene A Kretchy, Elfreda W Samman, Patience B Appiah, Imelda Bates
BACKGROUND: Voluntary blood donation rates are low in sub-Saharan Africa. Sociobehavioral factors such as a belief that donated blood would be used for performing rituals deter people from donating blood. There is a need for culturally appropriate communication interventions to encourage individuals to donate blood. Health care interventions that use mobile phones have increased in developing countries, although many of them focus on SMS text messaging (short message service, SMS). A unique feature of mobile phones that has so far not been used for aiding blood donation is caller tunes...
May 4, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29722887/mega-x-molecular-evolutionary-genetics-analysis-across-computing-platforms
#9
Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro Tamura
The molecular evolutionary genetics analysis (Mega) software implements many analytical methods and tools for phylogenomics and phylomedicine. Here, we report a transformation of Mega to enable cross-platform use on Microsoft Windows and Linux operating systems. Mega X does not require virtualization or emulation software and provides a uniform user experience across platforms. Mega X has additionally been upgraded to use multiple computing cores for many molecular evolutionary analyses. Mega X is available in two interfaces (graphical and command line) and can be downloaded from www...
May 2, 2018: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29713243/identification-of-four-differentially-methylated-genes-as-prognostic-signatures-for-stage-i-lung-adenocarcinoma
#10
Wei-Ming Luo, Zheng-Yu Wang, Xin Zhang
Background: Lung adenocarcinoma (LUAD) is the main subtype of non-small cell lung cancer with a low survival prognosis. We aimed to generate a prognostic model for the postoperative recurrence of LUAD. Methods: The methylated DNA data of LUAD patients were downloaded from the Cancer Genome Atlas (TCGA). The differentially methylated genes were identified and protein-protein interacting network was constructed, with which prognostic signature of this cancer was generated...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29698914/error-quantification-of-osteometric-data-in-forensic-anthropology
#11
Natalie R Langley, Lee Meadows Jantz, Shauna McNulty, Heli Maijanen, Stephen D Ousley, Richard L Jantz
This study evaluates the reliability of osteometric data commonly used in forensic case analyses, with specific reference to the measurements in Data Collection Procedures 2.0 (DCP 2.0). Four observers took a set of 99 measurements four times on a sample of 50 skeletons (each measurement was taken 200 times by each observer). Two-way mixed ANOVAs and repeated measures ANOVAs with pairwise comparisons were used to examine interobserver (between-subjects) and intraobserver (within-subjects) variability. Relative technical error of measurement (TEM) was calculated for measurements with significant ANOVA results to examine the error among a single observer repeating a measurement multiple times (e...
April 10, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29674313/key-lessons-and-impact-of-the-growing-healthy-mhealth-program-on-milk-feeding-timing-of-introduction-of-solids-and-infant-growth-quasi-experimental-study
#12
Rachel A Laws, Elizabeth A Denney-Wilson, Sarah Taki, Catherine G Russell, Miaobing Zheng, Eloise-Kate Litterbach, Kok-Leong Ong, Sharyn J Lymer, Rosalind Elliott, Karen J Campbell
BACKGROUND: The first year of life is an important window to initiate healthy infant feeding practices to promote healthy growth. Interventions delivered by mobile phone (mHealth) provide a novel approach for reaching parents; however, little is known about the effectiveness of mHealth for child obesity prevention. OBJECTIVE: The objective of this study was to determine the feasibility and effectiveness of an mHealth obesity prevention intervention in terms of reach, acceptability, and impact on key infant feeding outcomes...
April 19, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29642846/jami-a-java-library-for-molecular-interactions-and-data-interoperability
#13
M Sivade Dumousseau, M Koch, A Shrivastava, D Alonso-López, J De Las Rivas, N Del-Toro, C W Combe, B H M Meldal, J Heimbach, J Rappsilber, J Sullivan, Y Yehudi, S Orchard
BACKGROUND: A number of different molecular interactions data download formats now exist, designed to allow access to these valuable data by diverse user groups. These formats include the PSI-XML and MITAB standard interchange formats developed by Molecular Interaction workgroup of the HUPO-PSI in addition to other, use-specific downloads produced by other resources. The onus is currently on the user to ensure that a piece of software is capable of read/writing all necessary versions of each format...
April 11, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29608544/treatment-optimization-for-hepatocellular-carcinoma-in-elderly-patients-in-a-japanese-nationwide-cohort
#14
Masaki Kaibori, Kengo Yoshii, Kiyoshi Hasegawa, Asao Ogawa, Shoji Kubo, Ryosuke Tateishi, Namiki Izumi, Masumi Kadoya, Masatoshi Kudo, Takashi Kumada, Michiie Sakamoto, Osamu Nakashima, Yutaka Matsuyama, Tadatoshi Takayama, Norihiro Kokudo
OBJECTIVE: We reviewed nationwide follow-up data to determine outcomes of different treatments for early-stage hepatocellular carcinoma (HCC) in elderly patients. SUMMARY BACKGROUND DATA: Outcomes of early-stage HCC treatments in elderly patients have not been prospectively compared. METHODS: We included 6490 HCC patients, aged ≥75 years at treatment, who underwent curative hepatic resection (HR, n = 2020), radiofrequency ablation (RFA, n = 1888), microwave ablation (MWA, n = 193), or transcatheter arterial chemoembolization (TACE, n = 2389), and compared their characteristics and survival...
March 30, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29600049/three-dimensional-computed-tomography-reconstruction-for-operative-planning-in-robotic-segmentectomy-a-pilot-study
#15
Julien Le Moal, Christophe Peillon, Jean-Nicolas Dacher, Jean-Marc Baste
Background: The objective of our pilot study was to assess if three-dimensional (3D) reconstruction performed by Visible Patient™ could be helpful for the operative planning, efficiency and safety of robot-assisted segmentectomy. Methods: Between 2014 and 2015, 3D reconstructions were provided by the Visible Patient™ online service and used for the operative planning of robotic segmentectomy. To obtain 3D reconstruction, the surgeon uploaded the anonymized computed tomography (CT) image of the patient to the secured Visible Patient™ server and then downloaded the model after completion...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29579784/slugin-1-0-a-free-tool-for-automated-slug-test-analysis
#16
Sergio Martos-Rosillo, Carolina Guardiola-Albert, Alberto Padilla Benítez, Joaquín Delgado Pastor, Antonio Azcón González, Juan José Durán Valsero
The correct characterization of aquifer parameters is essential for water-supply and water-quality investigations. Slug tests are widely used for these purposes. While free software is available to interpret slug tests, some codes are not user-friendly, or do not include a wide range of methods to interpret the results, or do not include automatic, inverse solutions to the test data. The private sector has also generated several good programs to interpret slug test data, but they are not free of charge. The computer program SlugIn 1...
March 26, 2018: Ground Water
https://www.readbyqxmd.com/read/29576915/a-new-wrist-clinical-evaluation-score
#17
Guillaume Herzberg, Marion Burnier, Toshiyasu Nakamura
Background  The number of available wrist scoring systems is limited; some of them do not include forearm rotation criteria. Purpose  To describe a new electronic wrist clinical score and to present a new patient's generated wrist evaluation criterion, the subjective wrist value (SWV). Materials and Methods  A new electronic wrist clinical score, the Lyon wrist score (LWS) including wrist VAS pain and function, active range of motion and strength was built into an excel file. VAS flexion-extension pain and function were evaluated independently from pronation-supination pain and function...
April 2018: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/29571226/the-hyperbaric-oxygen-therapy-registry-driving-quality-and-demonstrating-compliance
#18
Caroline E Fife, Kristen A Eckert
Objective: To provide an update on the status of provider participation in the US Wound Registry (USWR) and its specialty registry the Hyperbaric Oxygen Therapy Registry (HBOTR), which provide much-needed national benchmarking and quality measurement services for hyperbaric medicine. Methods: Providers can meet many requirements of the Merit-Based Incentive Payment System (MIPS) and simultaneously participate in the HBOTR by transmitting Continuity of Care Documents (CCDs) directly from their certified electronic health record (EHR) or by reporting hyperbaric quality measures, the specifications for which are available free of charge for download from the registry website as electronic clinical quality measures for installation into any certified EHR...
January 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29563080/quality-of-publicly-available-physical-activity-apps-review-and-content-analysis
#19
REVIEW
Paulina Bondaronek, Ghadah Alkhaldi, April Slee, Fiona L Hamilton, Elizabeth Murray
BACKGROUND: Within the new digital health landscape, the rise of health apps creates novel prospects for health promotion. The market is saturated with apps that aim to increase physical activity (PA). Despite the wide distribution and popularity of PA apps, there are limited data on their effectiveness, user experience, and safety of personal data. OBJECTIVE: The purpose of this review and content analysis was to evaluate the quality of the most popular PA apps on the market using health care quality indicators...
March 21, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29549075/medication-adherence-apps-review-and-content-analysis
#20
REVIEW
Imran Ahmed, Niall Safir Ahmad, Shahnaz Ali, Shair Ali, Anju George, Hiba Saleem Danish, Encarl Uppal, James Soo, Mohammad H Mobasheri, Dominic King, Benita Cox, Ara Darzi
BACKGROUND: Medication adherence is an expensive and damaging problem for patients and health care providers. Patients adhere to only 50% of drugs prescribed for chronic diseases in developed nations. Digital health has paved the way for innovative smartphone solutions to tackle this challenge. However, despite numerous apps available claiming to improve adherence, a thorough review of adherence apps has not been carried out to date. OBJECTIVE: The aims of this study were to (1) review medication adherence apps available in app repositories in terms of their evidence base, medical professional involvement in development, and strategies used to facilitate behavior change and improve adherence and (2) provide a system of classification for these apps...
March 16, 2018: JMIR MHealth and UHealth
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