keyword
MENU ▼
Read by QxMD icon Read
search

free download

keyword
https://www.readbyqxmd.com/read/28807036/t-time-a-data-repository-of-t-cell-and-calcium-release-activated-calcium-channel-activation-imagery
#1
Cody Arbuckle, Milton Greenberg, Adrienne Bergh, Rene German, Nick Sirago, Erik Linstead
BACKGROUND: A fundamental understanding of live-cell dynamics is necessary in order to advance scientific techniques and personalized medicine. For this understanding to be possible, image processing techniques, probes, tracking algorithms and many other methodologies must be improved. Currently there are no large open-source datasets containing live-cell imaging to act as a standard for the community. As a result, researchers cannot evaluate their methodologies on an independent benchmark or leverage such a dataset to formulate scientific questions...
August 15, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28791895/cluster-a-new-application-for-spatial-analysis-of-pixelated-data-for-epiphytotics
#2
Scot Nelson, Iulian Corcoja, Sarah Jane Pethybridge
Spatial analysis of epiphytotics is essential to develop and test hypotheses about pathogen ecology, disease dynamics, and to optimize plant disease management strategies. Data collection for spatial analysis requires substantial investment in time to depict patterns in various frames and hierarchies. We developed a new approach for spatial analysis of pixelated data in digital imagery and incorporated the method in a stand-alone desktop application called Cluster. The user isolates target entities (clusters) by designating up to 24 pixel colors as nontargets and moves a threshold slider to visualize the targets...
August 9, 2017: Phytopathology
https://www.readbyqxmd.com/read/28777265/-i-did-not-want-to-give-birth-to-a-child-who-has-hiv-experiences-using-prep-during-pregnancy-among-hiv-uninfected-kenyan-women-in-hiv-serodiscordant-couples
#3
Jillian Pintye, Kristin M Beima-Sofie, Grace Kimemia, Kenneth Ngure, Susan Brown Trinidad, Renee Heffron, Jared Baeten, Josephine Odoyo, Nelly Mugo, Elizabeth A Bukusi, Maureen C Kelley, Grace C John-Stewart
OBJECTIVES: The perceptions, motivations, and beliefs of HIV-uninfected women about PrEP use during pregnancy can influence its uptake and adherence. This study elicited the views of HIV-uninfected women with personal experience taking PrEP during pregnancy. DESIGN: Qualitative interviews were conducted with HIV-uninfected women who had personal experience taking PrEP while pregnant. METHODS: Semi-structured interviews were conducted with 21 HIV-uninfected Kenyan women in HIV-serodiscordant couples enrolled in an open-label PrEP demonstration project who became pregnant while using PrEP and continued PrEP through their pregnancy...
July 31, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28777252/n-methyl-d-aspartate-receptor-nmdar-driven-calcium-influx-potentiates-the-adverse-effects-of-myocardial-ischemia-reperfusion-injury-ex-vivo
#4
Zi-You Liu, Shou Hu, Qin-Wen Zhong, Cheng-Nan Tian, Hou-Mou Ma, Jun-Jian Yu
BACKGROUND: Despite the adverse effects of N-methyl-D-aspartate receptor (NMDAR) activity in cardiomyocytes, no study has yet examined the effects of NMDAR activity under ex vivo ischemic-reperfusion (I/R) conditions. Therefore, our aim was to comprehensively evaluate the effects of NMDAR activity through an ex vivo myocardial I/R rat model. METHODS: Isolated rat hearts were randomly segregated into six groups (n=20 in each group): (i) an untreated control group; (ii) a NMDA-treated control group; (iii) an untreated I/R group; (iv) an I/R+NMDA group treated with NMDA; (v) an I/R+NMDA+MK-801 group treated with NMDA and the NMDAR inhibitor MK-801; and (vi) an I/R+NMDA+[Ca]-free group treated with NMDA and [Ca]-free buffer...
August 4, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28776963/structure_threader-an-improved-method-for-automation-parallelization-of-programs-structure-faststructure-and-maverick-on-multi-core-cpu-systems
#5
Francisco Pina-Martins, Diogo N Silva, Joana Fino, Octávio S Paulo
Structure_threader is a program to parallelize multiple runs of genetic clustering software that does not make use of multi-threading technology (structure, fastStructure and MavericK) on multi-core computers. Our approach was benchmarked across multiple systems and displayed great speed improvements relative to the single threaded implementation, scaling very close to linearly with the number of physical cores used. Structure_threader was compared to previous software written for the same task - ParallelStructure and StrAuto, and was proven to be the faster (up to 25% faster) wrapper under all tested scenarios...
August 4, 2017: Molecular Ecology Resources
https://www.readbyqxmd.com/read/28754122/snoopy-s-hybrid-simulator-a-tool-to-construct-and-simulate-hybrid-biological-models
#6
Mostafa Herajy, Fei Liu, Christian Rohr, Monika Heiner
BACKGROUND: Hybrid simulation of (computational) biochemical reaction networks, which combines stochastic and deterministic dynamics, is an important direction to tackle future challenges due to complex and multi-scale models. Inherently hybrid computational models of biochemical networks entail two time scales: fast and slow. Therefore, it is intricate to efficiently and accurately analyse them using only either deterministic or stochastic simulation. However, there are only a few software tools that support such an approach...
July 28, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/28753827/the-cpc-risk-calculator-a-new-app-to-predict-prostate-specific-antigen-recurrence-during-follow-up-after-radical-prostatectomy
#7
Martin Andreas Røder, Kasper Drimer Berg, Mathias Dyrberg Loft, Frederik Birkebæk Thomsen, Michelle Ferrari, Sorel Kurbegovic, Helene Charlotte Rytgaard, Lisa Gruschy, Klaus Brasso, Thomas Alexander Gerds, Andreas Kjær, James D Brooks, Peter Iversen
BACKGROUND: It can be challenging to predict the risk of biochemical recurrence (BR) during follow-up after radical prostatectomy (RP) in men who have undetectable prostate-specific antigen (PSA), even years after surgery. OBJECTIVE: To establish and validate a contemporary nomogram that predicts the absolute risk of BR every year after RP in men with undetectable PSA while accounting for competing risks of death. DESIGN, SETTING, AND PARTICIPANTS: A total of 3746 patients from Rigshospitalet (Copenhagen, Denmark) and Stanford Urology (Stanford, CA, USA) who underwent RP between 1995 and 2013 were included...
December 9, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28753264/lipidhunter-identifies-phospholipids-by-high-throughput-processing-of-lc-ms-and-shotgun-lipidomics-datasets
#8
Zhixu Ni, Georgia Angelidou, Mike Lange, Ralf Hoffmann, Maria Fedorova
Lipids are dynamic constituents of biological systems, rapidly responding to any changes in physiological conditions. Thus, there is a large interest in lipid-derived markers for diagnostic and prognostic applications, especially in translational and systems medicine research. As lipid identification remains a bottle-neck of modern untargeted lipidomics, we developed LipidHunter, a new open source software for the high-throughput identification of phospholipids in data acquired by LC-MS and shotgun experiments...
July 28, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28747297/photoaging-mobile-apps-as-a-novel-opportunity-for-melanoma-prevention-pilot-study
#9
Titus Josef Brinker, Dirk Schadendorf, Joachim Klode, Ioana Cosgarea, Alexander Rösch, Philipp Jansen, Ingo Stoffels, Benjamin Izar
BACKGROUND: Around 90% of melanomas are caused by ultraviolet (UV) exposure and are therefore eminently preventable. Unhealthy tanning behavior is mostly initiated in early adolescence, often with the belief that it increases attractiveness; the problems related to skin atrophy and malignant melanoma are too far in the future to fathom. Photoaging desktop programs, in which an image is altered to predict future appearance, have been successful in positively influencing behavior in adiposity or tobacco prevention settings...
July 26, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28746165/effect-of-immediate-initiation-of-antiretroviral-treatment-in-hiv-positive-individuals-aged-50-years-or-older
#10
Sara Lodi, Dominique Costagliola, Caroline Sabin, Julia Del Amo, Roger Logan, Sophie Abgrall, Peter Reiss, Ard van Sighem, Sophie Jose, Jose-Ramon Blanco, Victoria Hernando, Heiner C Bucher, Helen Kovari, Ferran Segura, Juan Ambrosioni, Charalambos A Gogos, Nikos Pantazis, Francois Dabis, Marie-Anne Vandenhende, Laurence Meyer, Rémonie Seng, John Gill, Hartmut Krentz, Andrew Phillips, Kholoud Porter, Beatriz Grinsztejn, Antonio G Pacheco, Roberto Muga, Janet Tate, Amy Justice, Miguel A Hernán
BACKGROUND: Clinical guidelines recommend immediate initiation of combined antiretroviral therapy (ART) for all HIV-positive individuals. However, those guidelines are based on trials of relatively young participants. METHODS: We included HIV-positive ART-naïve, AIDS-free individuals aged 50-70 years after 2004 in the HIV-CAUSAL Collaboration. We used the parametric g-formula to estimate the 5-year risk of all-cause and non-AIDS mortality under: i) immediate initiation at baseline, and initiation at CD4 count ii) <500 cells/mm, and iii) <350 cells/mm...
July 21, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28742992/utilizing-secondary-agricultural-education-programs-to-deliver-evidence-based-grain-safety-training-for-young-and-beginning-workers
#11
Yuan-Hsin Cheng, William E Field, Roger L Tormoehlen, Brian F French
Purdue University's Agricultural Safety and Health Program (PUASHP) has collaborated with secondary agricultural education programs, including FFA Chapters, for over 70 years to deliver and promote agricultural safety and health programming. With support from a U.S. Department of Labor Susan Harwood Program grant, PUASHP utilized a Developing a Curriculum (DACUM) process to develop, implement, and evaluate an evidence-based curriculum for use with young and beginning workers, ages 16-20, exposed to hazards associated with grain storage and handling...
July 25, 2017: Journal of Agromedicine
https://www.readbyqxmd.com/read/28720555/readability-of-wikipedia-pages-on-autoimmune-disorders-systematic-quantitative-assessment
#12
Abdulla Watad, Nicola Luigi Bragazzi, Francesco Brigo, Kassem Sharif, Howard Amital, Dennis McGonagle, Yehuda Shoenfeld, Mohammad Adawi
BACKGROUND: In the era of new information and communication technologies, the Internet is being increasingly accessed for health-related information. Indeed, recently published patient surveys of people with autoimmune disorders confirmed that the Internet was reported as one of the most important health information sources. Wikipedia, a free online encyclopedia launched in 2001, is generally one of the most visited websites worldwide and is often consulted for health-related information...
July 18, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28714760/houston-we-still-have-a-problem
#13
Martin Buchheit
Apollo 13 was initially looking like it would be the smoothest flight ever. After the explosion of an oxygen tank however, the astronauts were close to spending the rest of their lives in rotation around the planet. I wished to use this well-known incident to discuss further the link, or lack thereof, between sport sciences research and current field practices. There is a feeling that the academic culture and its publishing requirements have created a bit of an Apollo 13-like orbiting world (e.g., journals and conferences) that is mostly disconnected from the reality of elite performance...
July 17, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28697053/postoperative-adjuvant-therapy-for-resectable-pancreatic-cancer-with-gemcitabine-and-adoptive-immunotherapy
#14
Hiroto Matsui, Shoichi Hazama, Kazuhiko Sakamoto, Yoshitaro Shindo, Shinsuke Kanekiyo, Masao Nakashima, Satoshi Matsukuma, Yoshihiro Tokuhisa, Michihisa Iida, Nobuaki Suzuki, Kiyoshi Yoshimura, Shigeru Takeda, Tomio Ueno, Shigefumi Yoshino, Masaaki Oka, Hiroaki Nagano
OBJECTIVES: We previously described adoptive immunotherapy (AIT) with cytotoxic T lymphocytes (CTLs) stimulated by the mucin 1 (MUC1)-expressing human pancreatic cancer cell line YPK-1 (MUC1-CTLs) and demonstrated that MUC1-CTLs might prevent liver metastasis. In the present study, we combined gemcitabine (GEM) and AIT for the treatment of pancreatic cancer. METHODS: A total of 43 patients who underwent radical pancreatectomy received treatment with MUC1-CTLs and GEM...
July 11, 2017: Pancreas
https://www.readbyqxmd.com/read/28695803/bioinformatic-analysis-of-differentially-expressed-genes-in-peripheral-blood-of-human-immunodeficiency-virus-tubercle-bacilli-co-infected-patients
#15
Rongqiang Zhang, Qiling Liu, Na Sun, Wulin Kang, Puwei Yuan
Objective To analyze the differentially expressed genes in peripheral blood of human immunodeficiency(HIV)/tubercle bacilli co-infected patients and explore the biological regulatory mechanism and network of key proteins,so as to provide new evidence for early diagnosis and clinical treatment of HIV/TB co-infected patients. Methods Microarray gene chip data of HIV/TB co-infected patients were downloaded from public databases GEO and imported into the analysis software GEO,STRING,PANTHER,and GenClip. The gene expression profiles,protein interaction networks,processes of molecular biology,and gene functions were analyzed...
June 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28683005/the-use-of-endometrial-cancer-patient-derived-organoid-culture-for-drug-sensitivity-testing-is-feasible
#16
Eugenia Girda, Eric C Huang, Gary S Leiserowitz, Lloyd H Smith
OBJECTIVE: Patient-derived organoids (PDOs), used in multiple tumor types, have allowed evaluation of tumor characteristics from individual patients. This study aimed to assess the feasibility of applying PDO in vitro culture for endocrine-based and drug sensitivity testing in endometrial cancer. METHODS: Endometrial cancer cells were enzymatically dissociated from tumors retrieved from fresh hysterectomy specimens and cultured within basement membrane extract in serum-free medium...
July 5, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28682834/high-expression-of-yes-activated-protein-1-in-papillary-thyroid-carcinoma-correlates-with-poor-prognosis
#17
Zeming Liu, Wen Zeng, Yusufu Maimaiti, Jie Ming, Yawen Guo, Yan Liu, Chunping Liu, Tao Huang
CONTEXT: The Hippo signal transduction pathway is highly conserved in mammals. It plays a critical role in tissue and organ size by regulating the balance between cell proliferation and apoptosis. However, there have been few reports concerning Yes-activated protein-1 (YAP-1) elevation in papillary thyroid cancer (PTC). OBJECTIVE: The objective of this study was to determine whether YAP-1 expression is a biomarker and high-risk clinicopathologic prognosticator in PTC...
July 4, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28678321/pde3a-is-hypermethylated-in-cisplatin-resistant-non-small-cell-lung-cancer-cells-and-is-a-modulator-of-chemotherapy-response
#18
F-M Tian, C-Y Zhong, X-N Wang, Y Meng
OBJECTIVE: In this study, we aimed to investigate the mechanism of PDE3A downregulation in chemoresistant non-small cell lung cancer (NSCLC) cells, its functional role in chemotherapy response and association with survival outcomes. MATERIALS AND METHODS: The raw data of GDS5247 was downloaded from GEO datasets and reanalyzed. The expression of PDE3A in patients with NSCLC and its DNA methylation status were analyzed in NSCLC cohort in TCGA database. Cisplatin resistant A549/Cis cells and the parental A549 cells were used as the in vitro cell model...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28670277/nano-lazar-read-across-predictions-for-nanoparticle-toxicities-with-calculated-and-measured-properties
#19
Christoph Helma, Micha Rautenberg, Denis Gebele
The lazar framework for read across predictions was expanded for the prediction of nanoparticle toxicities, and a new methodology for calculating nanoparticle descriptors from core and coating structures was implemented. Nano-lazar provides a flexible and reproducible framework for downloading data and ontologies from the open eNanoMapper infrastructure, developing and validating nanoparticle read across models, open-source code and a free graphical interface for nanoparticle read-across predictions. In this study we compare different nanoparticle descriptor sets and local regression algorithms...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28667915/knockdown-of-tnf-receptor-associated-factor-2-traf2-modulates-in-vitro-growth-of-trail-treated-prostate-cancer-cells
#20
Bingbing Wei, Jun Ruan, Yuanyuan Mi, Jimeng Hu, Jian Zhang, Zhirong Wang, Qiang Hu, Haowen Jiang, Qiang Ding
TNF receptor-associated factor 2 (TRAF2) is documented to regulate tumor development and progression. Currently, the effect of TRAF2 on growth of androgen-refractory prostate cancer in response to TRAIL and the molecular mechanisms are not well understood. Here, we aim to investigate the effect of TRAF2 on in vitro growth of human androgen-insensitive prostate cancer DU-145 cells in the presence of TRAIL. Bioinformatics analysis of the Cancer Genome Atlas (TCGA) data was performed to examine TRAF2 expression and the prognostic value in prostate cancer...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
keyword
keyword
106140
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"