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https://www.readbyqxmd.com/read/28910600/an-acceptor-analogue-of-%C3%AE-1-4-galactosyltransferase-substrate-inhibitor-or-both
#1
Jingqian Jiang, Gerd K Wagner
Many glycosyltransferase inhibitors in the literature are structurally derived from the donor or acceptor substrate of the respective enzyme. A representative example is 2-naphthyl β-d-GlcNAc, a synthetic GlcNAc glycoside that has been reported as a galactosyltransferase inhibitor. This GlcNAc derivative is attractive as a chemical tool compound for biological and biochemical studies because of its reported potency as an inhibitor, and its short and straightforward synthesis from readily available starting materials...
August 31, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28903856/triphenylamine-based-hypercrosslinked-organic-polymer-as-adsorbent-for-the-extraction-of-phenylurea-herbicides
#2
Juanjuan Wu, Ruiyang Ma, Lin Hao, Chun Wang, Qiuhua Wu, Zhi Wang
A hypercrosslinked organic polymer material (named as PPTPA) was prepared by a simple one-step self-polycondensation of triphenylamine. A series of characterization experiments, including N2 adsorption, scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectra, and thermogravimetric analysis, were carried out to evaluate the morphology, structure and other intrinsic properties of the PPTPA. To investigate its adsorption performance, the PPTPA was used as the solid-phase extraction adsorbent for the extraction of phenylurea herbicides from water, milk and tomato juice samples followed by high-performance liquid chromatographic analysis...
September 6, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28903176/assessment-of-pcbs-and-exposure-risk-to-infants-in-breast-milk-of-primiparae-and-multiparae-mothers-in-an-electronic-waste-hot-spot-and-non-hot-spot-areas-in-ghana
#3
Anita Asamoah, David Kofi Essumang, Jens Muff, Sergey V Kucheryavskiy, Erik Gydesen Søgaard
The aim of the study was to assess the levels of PCBs in the breast milk of some Ghanaian women at suspected hotspot and relatively non-hotspot areas and to find out if the levels of these PCBs pose any risk to the breastfed infants. A total of 128 individual human breast milk were sampled from both primiparae and multiparae mothers. The levels of PCBs in the milk samples were compared. Some of these mothers (105 individuals) work or reside in and around Agbogbloshie (hot-spot), the largest electric and electronic waste dump and recycling site in Accra, Ghana...
September 9, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28858132/a-retrospective-study-on-the-effects-of-exclusive-donor-human-milk-feeding-in-a-short-period-after-birth-on-morbidity-and-growth-of-preterm-infants-during-hospitalization
#4
Eun Jeong Kim, Na Mi Lee, Sung-Hoon Chung
The risks and benefits of feeding preterm formula (PF) versus donor human milk (DHM) in preterm infants are uncertain, and studies evaluating the efficacy of DHM to the morbidities and growth of preterm infants in the neonatal intensive care unit are confused by the need for milk fortification. We aimed to determine and compare the outcome of short-term morbidities in neonatal intensive care unit and growth between premature infants fed exclusively DHM only until a volume of 130 mL/kg/d of enteral feeding was achieved and infants fed with a PF mix after birth...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28829161/cost-and-cost-effectiveness-of-donor-human-milk-to-prevent-necrotizing-enterocolitis-systematic-review
#5
Abigail Buckle, Celia Taylor
BACKGROUND: Necrotizing enterocolitis (NEC) is a costly gastrointestinal disorder that mainly affects preterm and low-birth-weight infants and can lead to considerable morbidity and mortality. Mother's own milk is protective against NEC but is not always available. In such cases, donor human milk has also been shown to be protective (although to a lesser extent) compared with formula milk, but it is more expensive. This systematic review aimed at evaluating the cost of donor milk, the cost of treating NEC, and the cost-effectiveness of exclusive donor milk versus formula milk feeding to reduce the short-term health and treatment costs of NEC...
August 22, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28822444/-progress-in-studies-on-human-milk-bank-and-donor-human-milk
#6
Z B Yu, S P Han
No abstract text is available yet for this article.
August 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28822435/-characteristics-of-the-chinese-human-milk-banks-operation
#7
(no author information available yet)
Objective: To assess the operation status of human milk banks in the mainland of China. Method: This retrospective study included a consecutive series of 14 human milk banks in the mainland of China from March 2013 to December 2016. The opened date, condition of donated breast milk, characteristics of donors and clinical application of donated breast milk were analyzed. Result: There were 14 human milk banks successively founded in mainland China from March 2013 to December 2016. The number of human milk banks, the amount of donated breast milk, the number of eligible donors and the times of donation had increased each year...
August 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28800816/an-investigation-of-vtx2-bacteriophage-transduction-to-different-escherichia-coli-patho-groups-in-food-matrices-and-nutrient-broth
#8
Sepo Nyambe, Catherine Burgess, Paul Whyte, Declan Bolton
This study investigated bacteriophage (phage) mediated transfer of the vtx2 gene from a donor Escherichia coli (C600φ3538(Δvtx2::cat)) to enteropathogenic (EPEC), enterotoxigenic (ETEC), enteroaggregative (EAEC), enteroinvasive (EIEC) and diffusely adherent (DAEC) E. coli strains in LB broth, milk, ground beef and lettuce. Two bacterial concentrations for both the E. coli donor and recipient strains, 3 and 5 log10 CFU/ml (LB broth and milk)/g (beef) or/cm(2) (lettuce), were used. When transductants were obtained, the location of insertion of the phage (insertion sites wrbA, yehA, sbcB, yecE and/or Z2577) in the E...
December 2017: Food Microbiology
https://www.readbyqxmd.com/read/28783445/donor-milk-or-formula-a-qualitative-study-of-postpartum-mothers-of-healthy-newborns
#9
Laura R Kair, Valerie J Flaherman
BACKGROUND: Many breastfed infants receive supplemental feeds during the birth hospitalization, either by maternal request or due to medical indications. Donor milk from a certified milk bank has become increasingly available and is now used in some settings for term and late preterm infants. No studies have explored maternal opinions about donor milk and formula as options for supplementary feedings. Research aim: This study aimed to explore maternal perceptions about donor milk and formula supplementation and implications for continued breastfeeding...
July 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28768852/septic-episodes-in-a-premature-infant-after-in-utero-exposure-to-rituximab
#10
Susanne Hay, Sandra Burchett, Oreofe Odejide, Sule Cataltepe
Rituximab is an increasingly used immunotherapeutic agent for women of reproductive age for treatment of autoimmune diseases, leukemias, and lymphomas. Rituximab is a chimeric monoclonal antibody that targets B-cell surface antigen CD20 and can cross the placenta. Current evidence of the impact of this medication on the developing fetus is limited, but there is little to suggest that fetal exposure to this medication places an infant at increased risk of immunosuppression and subsequent infection. Here we report a case of in utero rituximab exposure that was associated with 2 severe septic episodes with Enterococcus faecalis, in a premature infant of 29 weeks' gestational age with a birth weight of 820 g...
September 2017: Pediatrics
https://www.readbyqxmd.com/read/28765581/oropharyngeal-mucosal-transmission-of-zika-virus-in-rhesus-macaques
#11
Christina M Newman, Dawn M Dudley, Matthew T Aliota, Andrea M Weiler, Gabrielle L Barry, Mariel S Mohns, Meghan E Breitbach, Laurel M Stewart, Connor R Buechler, Michael E Graham, Jennifer Post, Nancy Schultz-Darken, Eric Peterson, Wendy Newton, Emma L Mohr, Saverio Capuano, David H O'Connor, Thomas C Friedrich
Zika virus is present in urine, saliva, tears, and breast milk, but the transmission risk associated with these body fluids is currently unknown. Here we evaluate the risk of Zika virus transmission through mucosal contact in rhesus macaques. Application of high-dose Zika virus directly to the tonsils of three rhesus macaques results in detectable plasma viremia in all animals by 2 days post-exposure; virus replication kinetics are similar to those observed in animals infected subcutaneously. Three additional macaques inoculated subcutaneously with Zika virus served as saliva donors to assess the transmission risk from contact with oral secretions from an infected individual...
August 1, 2017: Nature Communications
https://www.readbyqxmd.com/read/28764968/production-of-human-milk-oligosaccharides-by-enzymatic-and-whole-cell-microbial-biotransformations
#12
Georg A Sprenger, Florian Baumgärtner, Christoph Albermann
Human milk oligosaccharides (HMO) are almost unique constituents of breast milk and are not found in appreciable amounts in cow milk. Due to several positive aspects of HMO for the development, health, and wellbeing of infants, production of HMO would be desirable. As a result, scientists from different disciplines have developed methods for the preparation of single HMO compounds. Here, we review approaches to HMO preparation by (chemo-)enzymatic syntheses or by whole-cell biotransformation with recombinant bacterial cells...
July 29, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28749825/a-fortified-donor-milk-policy-is-associated-with-improved-in-hospital-head-growth-and-weight-gain-in-very-low-birth-weight-infants
#13
Gemma Ginovart, Ignasi Gich, Antonio Gutiérrez, Sergio Verd
BACKGROUND: Previous research has reported that infants fed donor milk grow slower than those fed formula. However, most of the trials used unfortified donor milk, which limits the ability to generalize the results to current clinical practice. PURPOSE: To evaluate the impact of early human milk feeding (donor milk and/or mother's own milk) with standard fortification on in-hospital growth of very low-birth-weight infants. METHODS: This pre-/postretrospective study included selected newborn infants less than 1500 g admitted to a level IV neonatal intensive care unit before and after the introduction of a policy providing donor milk when mother's own milk was not available in sufficient quantity to meet her infant's need...
August 2017: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/28742378/effect-of-the-various-steps-in-the-processing-of-human-milk-in-the-concentrations-of-iga-igm-and-lactoferrin
#14
Gerardo Arroyo, Kevin Alexander Ortiz Barrientos, Karla Lange, Federico Nave, Gabriela Miss Mas, Pamela Lam Aguilar, Miguel Angel Soto Galindo
INTRODUCTION: Human milk immune components are unique and important for the development of the newborn. Milk processing at the Human Milk Banks (HMB), however, causes partial destruction of immune proteins. The objective of this study was to determine the effects that heating during the milk processing procedure at the HMB had on the concentrations of IgA, IgM, and lactoferrin at three critical points in time. MATERIALS AND METHODS: Fifty milk samples (150 mL) were collected from voluntary donors at the HMB at the Hospital Nacional Pedro de Bethancourt, located in Antigua Guatemala...
September 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28740388/role-of-tim-4-in-exosome-dependent-entry-of-hiv-1-into-human-immune-cells
#15
Brian Sims, Anitra L Farrow, Sparkle D Williams, Anju Bansal, Alexandre Krendelchtchikov, Linlin Gu, Qiana L Matthews
Exosomes, 30-200 nm nanostructures secreted from donor cells and internalized by recipient cells, can play an important role in the cellular entry of some viruses. These microvesicles are actively secreted into various body fluids, including blood, urine, saliva, cerebrospinal fluid, and breast milk. We successfully isolated exosomes from human breast milk and plasma. The size and concentration of purified exosomes were measured by nanoparticle tracking, while Western blotting confirmed the presence of the exosomal-associated proteins CD9 and CD63, clathrin, and T cell immunoglobulin and mucin proteins (TIMs)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28714111/room-for-improvement-in-breast-milk-feeding-after-very-preterm-birth-in-europe-results-from-the-epice-cohort
#16
Emilija Wilson, Anna-Karin Edstedt Bonamy, Mercedes Bonet, Liis Toome, Carina Rodrigues, Elizabeth A Howell, Marina Cuttini, Jennifer Zeitlin
Breast milk feeding (BMF) is associated with lower neonatal morbidity in the very preterm infant (<32 weeks gestation) and breastfeeding is beneficial for maternal health. Previous studies show large variations in BMF after very preterm birth and recognize the need for targeted breastfeeding support in the neonatal intensive care units (NICU). In a European collaboration project about evidence-based practices after very preterm birth, we examined the association between maternal, obstetric, and infant clinical factors; neonatal and maternal care unit policies; and BMF at discharge from the NICU...
July 17, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28691975/stability-of-cortisol-and-cortisone-in-human-breast-milk-during-holder-pasteurization
#17
Bibian van der Voorn, Marita de Waard, Lisette R Dijkstra, Annemieke C Heijboer, Joost Rotteveel, Johannes B van Goudoever, Martijn J J Finken
Human donor milk is the feeding of choice for preterm infants, when own mother's milk is not available. Holder pasteurization is necessary to secure the safety of donor milk, although it can affect milk quality by reduction of nutritional and bioactive components. Recently, research has focused on the potential role of breast-milk glucocorticoids for infant development. At this moment, it is unknown whether pasteurization affects milk glucocorticoid levels. Therefore, we assessed whether Holder pasteurization, the most frequently used method nowadays, reduces breast-milk cortisol and cortisone levels, using breast milk samples from 30 women who delivered at term...
July 6, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28690067/transient-changes-in-milk-production-efficiency-and-bacterial-community-composition-resulting-from-near-total-exchange-of-ruminal-contents-between-high-and-low-efficiency-holstein-cows
#18
Paul J Weimer, Madison S Cox, Tania Vieira de Paula, Miao Lin, Mary Beth Hall, Garret Suen
The objectives of this study were to determine if milk production efficiency (MPE) is altered by near-total exchange of ruminal contents between high- (HE) and low-MPE (LE) cows and to characterize ruminal bacterial community composition (BCC) before exchange and over time postexchange. Three pairs of ruminally cannulated, third-lactation cows were selected whose MPE (energy-corrected milk per unit of dry matter intake) differed over their first 2 lactations. Approximately 95% of ruminal contents were exchanged between cows within each pair...
September 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28685670/milk-donor-blood-screening-for-hiv-syphilis-and-hepatitis-b-markers-in-a-brazilian-human-milk-bank-prevalence-time-trends-over-the-2005-2015-period
#19
Emil Kupek, Estela Olivo Savi
BACKGROUND: Human milk banking has been promoted to provide donated breast milk for at-risk children whose mothers cannot breastfeed them but this effort was hindered by the advent of HIV epidemic. OBJECTIVE: To estimate the seroprevalence of HIV, syphilis and hepatitis B in the blood of human milk donors registered in a major maternity hospital in the northern region of the Santa Catarina State, Brazil. METHODS: A retrospective study included serological tests for HIV, syphilis and hepatitis B screening of milk donor candidates in the 2005-2015 period...
July 7, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28643867/transfusion-transmitted-cmv-infection%C3%A2-%C3%A2-current-knowledge-and-future-perspectives
#20
REVIEW
M Ziemann, T Thiele
Transmission of human cytomegalovirus (CMV) via transfusion (TT-CMV) may still occur and remains a challenge in the treatment of immunocompromised CMV-seronegative patients, e.g. after stem cell transplantation, and for low birthweight infants. Measures to reduce the risk of TT-CMV have been evaluated in clinical studies, including leucocyte depletion of cellular blood products and/or the selection of CMV-IgG-negative donations. Studies in large blood donor cohorts indicate that donations from newly CMV-IgG-positive donors should bear the highest risk for transmitting CMV infections because they contain the highest levels of CMV-DNA, and early CMV antibodies cannot neutralise CMV...
June 23, 2017: Transfusion Medicine
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