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donor milk

Shelley Thibeau, Harley G Ginsberg
No abstract text is available yet for this article.
2018: Ochsner Journal
Wyatt E Lanik, Lily Xu, Cliff J Luke, Elise Z Hu, Pranjal Agrawal, Victoria S Liu, Rajesh Kumar, Alexa M Bolock, Congrong Ma, Misty Good
Human small intestinal enteroids are derived from the crypts and when grown in a stem cell niche contain all of the epithelial cell types. The ability to establish human enteroid ex vivo culture systems are important to model intestinal pathophysiology and to study the particular cellular responses involved. In recent years, enteroids from mice and humans are being cultured, passaged, and banked away for future use in several laboratories across the world. This enteroid platform can be used to test the effects of various treatments and drugs and what effects are exerted on different cell types in the intestine...
February 15, 2018: Journal of Visualized Experiments: JoVE
Elizabeth A Brownell, Adam P Matson, Kelsey C Smith, James E Moore, Patricia A Esposito, Mary M Lussier, Trudy J Lerer, James I Hagadorn
BACKGROUND: A dose-response relationship between proportions of donor human milk (DHM) intake and in-neonatal intensive care unit (in-NICU) growth rates, if any, remains poorly defined. Objective was to evaluate interrelationships between percentages of DHM, mother's own milk (MOM), and preterm formula (PF) intake and neonatal growth parameters at 36 weeks postmenstrual age or NICU discharge. METHODS: Infants eligible for this single-center retrospective study were inborn at ≤32 weeks gestation or ≤1800 g, stayed in the NICU for ≥7 days, and received enteral nutrition consisting of human milk fortified with Enfamil human milk fortifier acidified liquid...
March 14, 2018: Journal of Pediatric Gastroenterology and Nutrition
Ángel Sánchez-Illana, Anna Parra-Llorca, Diana Escuder-Vieco, Carmen Rosa Pallás-Alonso, María Cernada, María Gormaz, Máximo Vento, Julia Kuligowski
Oxidative stress derived biomarkers have been extensively studied for assessing pathological situations in the neonatal period and their usefulness for an early outcome prediction of oxidative stress related diseases in non-invasive biofluids could be demonstrated. This is the first report on a method for the simultaneous detection of a panel of oxidative stress related biomarkers for quantifying damage to proteins and DNA in human breast milk samples. A straightforward sample clean-up procedure using 1.5 mL of milk was developed and extracts were analyzed by ultra-performance liquid chromatography coupled to tandem mass spectrometry...
August 3, 2018: Analytica Chimica Acta
F Vela-Soria, L M Iribarne-Durán, V Mustieles, I Jiménez-Díaz, M F Fernández, N Olea
Concerns are growing about human exposure to endocrine disrupting chemicals (EDCs), especially during developmental stages. Parabens (PBs) and ultraviolet filters (UVFs) are prevalent EDCs widely used as additives in cosmetics and personal care products (PCPs). The objective of this study was to develop a method to determine four PBs and ten UVFs in human milk using QuEChERS treatment and ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). Multivariate strategies were applied to optimize experimental parameters...
March 6, 2018: Journal of Chromatography. A
Masaharu Somiya, Yusuke Yoshioka, Takahiro Ochiya
Extracellular vesicles (EVs) deliver biologically active cargos from donor cells to recipient cells for intercellular communication. Since the existence of RNA cargo was discovered, EVs have been considered to be useful drug-delivery systems. Specifically, EVs from bovine milk (mEV) are one of the most promising platforms, since bovine milk is a scalable source of EVs for mass production. However, it is still difficult to isolate pure EVs from bovine milk owing to the complexity of raw materials. Furthermore, the biocompatibility and immunotoxicity of mEVs are still unclear...
2018: Journal of Extracellular Vesicles
Irene A Stafford, Eliza Rodrigue, Alexandra Berra, Wesley Adams, Asha J Heard, Joseph L Hagan, Shawn J Stafford
BACKGROUND: Necrotizing enterocolitis (NEC) is a leading cause of newborn gastrointestinal emergencies, affecting 1-3 per 1000 live births. Although NEC has been linked to a microbial etiology, associations with maternal intrapartum and resultant newborn early-onset invasive Group B streptococcus (EO-GBS) have been weakly defined. OBJECTIVE: The study aim was to determine the relationship between EO-GBS and NEC. STUDY DESIGN: Data from 2008 to 2015 were collected from pediatric records with ICD diagnosis codes consistent with all stages of NEC, with the exception of neonatal EO-GBS data (only available 2011-2015)...
February 24, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Atefeh Sarafan Sadeghi, Mohammad Mohsenzadeh, Khalil Abnous, Seyed Mohammad Taghdisi, Mohammad Ramezani
Specific ssDNA aptamers for the antibiotic florfenicol (FF) were developed from an enriched nucleotide library using magnetic beads-based SELEX (Systematic Evolution of Ligands by EXponential enrichment) technique with high-binding affinity. After 12 rounds of selection, thirty-six sequences were obtained that were then divided into five major families, according to the primary sequence similarity. Binding affinity analyses of three fluorescently tagged aptamers belonging to different families demonstrated that the dissociation constants (Kd ) were in the low nanomolar range (Kd = 52...
May 15, 2018: Talanta
Javier Calvo, Nadia Raquel García Lara, María Gormaz, Manuela Peña, María José Martínez Lorenzo, Pilar Ortiz Murillo, Josep Maria Brull Sabaté, Carmen María Samaniego, Antoni Gayà
It is widely agreed that the best source of nutrition for the newborn is the milk of their own mothers. In those cases where it is not available, especially in very premature and/or very low birth weight infants, as well as other sick newborns, the preferred choice before formula is the human milk provided by selected donors. This indication is supported by the highest international bodies dedicated to the health of the child population, including the World Health Organisation as well as the main national and international scientific societies in the field of Paediatrics...
February 26, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
Susan Trang, John A F Zupancic, Sharon Unger, Alex Kiss, Nicole Bando, Sabrina Wong, Sharyn Gibbins, Deborah L O'Connor
OBJECTIVES: To determine the cost-effectiveness of supplemental donor human milk (DHM) versus preterm formula (PTF) for very low birth weight (VLBW, <1500 g) infants from a societal perspective to 18 months' corrected age. METHODS: This prospective cost-effectiveness analysis of 363 VLBW infants was conducted for a randomized control trial. Infants recruited from October 2010 to December 2012 were fed DHM or PTF whenever mother's milk was unavailable. Formal health care costs for initial hospitalization and readmissions were obtained from standardized cost-accounting systems and physician fees...
February 28, 2018: Pediatrics
Carla Regina Bianchi Codo, Jamil Pedro de Siqueira Caldas, Rafaella Regina Alves Peixoto, Vitor Lacerda Sanches, Tamara Cristina Guiraldelo, Solange Cadore, Sérgio Tadeu Martins Marba
OBJECTIVE: To determine and compare the concentrations of electrolytes and minerals in three different types of maternal milk samples: term donor milk before pasteurization, term donor milk after pasteurization and raw milk of mothers of preterm newborns at bedside. METHODS: Descriptive cross-sectional study. Concentrations of calcium (Ca), phosphorous (P), magnesium (Mg), sodium (Na) and potassium (K) were measured in random samples of three human breast milk groups...
February 22, 2018: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
Diane L Spatz
No abstract text is available yet for this article.
February 23, 2018: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
Laura M Candelaria, Diane L Spatz, Noreen Giordano
OBJECTIVE: To examine the experiences of women who donated breast milk to a hospital-based milk bank regulated under the policies and procedures set forth by the Human Milk Banking Association of North America (HMBANA). DESIGN: Qualitative, phenomenological design. SETTING: The Mothers' Milk Bank in a children's hospital in the Northeastern region of the United States. PARTICIPANTS: Twelve HMBANA-approved milk donors older than 21 years with infants hospitalized in the NICU...
February 22, 2018: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
Jing Sun, Yanqi Li, Duc Ninh Nguyen, Martin S Mortensen, Chris H P van den Akker, Tom Skeath, Susanne E Pors, Stanislava Pankratova, Silvia Rudloff, Søren J Sørensen, Douglas G Burrin, Thomas Thymann, Per T Sangild
Background: Nutrient fortification of human milk is often required to secure adequate growth and organ development for very preterm infants. There is concern that formula-based fortifiers (FFs) induce intestinal dysfunction, feeding intolerance, and necrotizing enterocolitis (NEC). Bovine colostrum (BC) may be an alternative nutrient fortifier, considering its high content of protein and milk bioactive factors. Objective: We investigated whether BC was superior to an FF product based on processed bovine milk and vegetable oil to fortify donor human milk (DHM) for preterm pigs, used as a model for infants...
February 16, 2018: Journal of Nutrition
Eduardo Villamor-Martínez, Maria Pierro, Giacomo Cavallaro, Fabio Mosca, Boris W Kramer, Eduardo Villamor
Bronchopulmonary dysplasia (BPD) is the most common complication after preterm birth. Pasteurized donor human milk (DHM) has increasingly become the standard of care for very preterm infants over the use of preterm formula (PF) if the mother's own milk (MOM) is unavailable. Studies have reported beneficial effects of DHM on BPD. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) and observational studies on the effects of DHM on BPD and other respiratory outcomes. Eighteen studies met the inclusion criteria...
February 20, 2018: Nutrients
L Affumicato, T Sánchez Tamayo, M G Espinosa Fernandez, M Peña Caballero, C E Ruiz Morcillo, R Acebes Tosti, E Salguero García
INTRODUCTION: Donor milk is the second best alternative for a newborn after the mother's own milk, especially when the baby is a premature or a sick child since this milk has the advantage of protecting against necrotizing enterocolitis. There are currently 13 milk banks in Spain, however this is not sufficient to supply all Spanish neonatal units with donor milk. In order to bring donor milk to the babies in Neonatal Unit of the Regional University Hospital of Malaga, a Satellite Centre (CS) was created in 2012, depending on the Milk Bank of Virgen de las Nieves Hospital in Granada...
February 14, 2018: Revista de Calidad Asistencial: Organo de la Sociedad Española de Calidad Asistencial
C Battersby, R Marciano Alves Mousinho, N Longford, N Modi
OBJECTIVES: To describe the use of pasteurised human donor milk (pHDM) in England and the influence of a human milk bank in the network. DESIGN: Prospective observational study SETTING: All 163 neonatal units (23 networks) in England 2012-2013. PATIENTS: Preterm infants born at <32 weeks gestational age (GA). MAIN OUTCOME MEASURES: Proportion of infants and care-days fed pHDM during the first 30 postnatal days by network METHODS: We extracted daily patient-level data from the National Neonatal Research Database (NNRD)...
February 14, 2018: Early Human Development
Pasinee Kanaprach, Nutkridta Pongsakul, Nopporn Apiwattanakul, Chatchai Muanprasat, Sarayut Supapannachart, Pracha Nuntnarumit, Somchai Chutipongtanate
BACKGROUND: Donor human milk is considered the next best nutrition following mother's own milk to prevent neonatal infection and necrotizing enterocolitis in preterm infants who are admitted at neonatal intensive care unit. However, donor milk biofunctionalities after preparative processes have rarely been documented. OBJECTIVE: To evaluate biofunctionalities preserved in donor milk after preparative processes by cell-based assays. MATERIALS AND METHODS: Ten pools of donor milk were produced from 40 independent specimens...
February 16, 2018: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
Robert K Huston, Andrea M Markell, Elizabeth A McCulley, Stuart K Gardiner, Sean L Sweeney
BACKGROUND: An exclusive human milk diet (EHM) fortified with human milk-based fortifier decreases necrotizing enterocolitis (NEC) compared to maternal milk supplemented with preterm formula and bovine fortifier (PTF). Growth has been less with EHM and also maternal milk supplemented with donor human milk and bovine fortifier (HMBF). The objective was to evaluate the effect of a standardized feeding protocol on the growth of infants ≤1250 g birth weight supported with EHM and HMBF. The effect on the incidence of NEC was also evaluated...
February 16, 2018: Nutrition in Clinical Practice
Molly R Rabinowitz, Laura R Kair, Heather L Sipsma, Carrie A Phillipi, Ilse A Larson
BACKGROUND: Breastfeeding is fundamental to maternal and child health and is the most cost-effective intervention to reduce child mortality. Pasteurized human donor milk (HDM) is increasingly provided for term newborns requiring temporary supplementation. Few studies examine maternal perspectives on supplementation of term newborns. MATERIALS AND METHODS: We conducted semistructured in-person interviews with mothers of term newborns (n = 24) during postpartum hospitalization...
February 13, 2018: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
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