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hemochromatosis thrombocytopenia

Pierre De Marini, Annegret Laplace, Julien Matuszak, Luc-Matthieu Fornecker, Izzie Jacques Namer
A 21-year-old man, allogeneic hematopoietic stem cell transplantation recipient, was referred to our nuclear medicine department for a suspicion of knee osteonecrosis. Bone scan with Tc-HMDP did not show abnormal bone uptake but an intense spleen accumulation. F-FDG PET/CT performed on the same day showed no pathological spleen uptake. The patient had secondary hemochromatosis resulting from frequent transfusions in the setting of a chronic graft versus host disease with hemolysis and thrombocytopenia. The last RBC and platelet transfusions were performed 9 and 2 days before the examination, respectively...
October 2016: Clinical Nuclear Medicine
Sharon Lewin, James B Bussel
The fetoplacental interface plays a unique role in pathologies of the fetus and neonate, and is increasingly being recognized for effects on fetal and neonatal development that resonate into adulthood. In this review, we will use several exemplary disorders involving each of the 3 types of blood cells to explore the effect of perinatal insults on subsequent development of the affected cell line. We will present new data regarding outcomes of infants treated prenatally for fetal and neonatal alloimmune thrombocytopenia (FNAIT) and contrast these with outcomes of infants affected by hemolytic disease of the fetus and newborn...
January 2015: Clinical Advances in Hematology & Oncology: H&O
Bethanee J Schlosser, Megan Pirigyi, Ginat W Mirowski
Oral manifestations of hematologic and nutritional deficiencies can affect the mucous membranes, teeth, periodontal tissues, salivary glands, and perioral skin. This article reviews common oral manifestations of hematologic conditions starting with disorders of the white blood cells including cyclic hematopoiesis (cyclic neutropenia), leukemias, lymphomas, plasma cell dyscrasias, and mast cell disorders; this is followed by a discussion of the impact of red blood cell disorders including anemias and less common red blood cell dyscrasias (sickle cell disease, hemochromatosis, and congenital erythropoietic porphyria) as well as thrombocytopenia...
February 2011: Otolaryngologic Clinics of North America
Lauree Pearson, Robin Bissinger, Kelly R Romero
Neonatal hemochromatosis is a rare disease of iron metabolism, characterized by the excess accumulation of iron in the tissues. This occurs in utero and can lead to fetal demise or an infant who presents with advanced liver disease in the neonatal period. A case of neonatal hemochromatosis is reported in a 37-week infant who presented at birth with thrombocytopenia, coagulopathy, and abnormal liver imaging studies. The diagnoses of infection and metabolic errors were excluded before the confirmation of neonatal hemochromatosis was made...
April 2009: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
I Pache, E-L Leung Ki, A Antonino, D Moradpour
This review highlights recent advances in hepatology, including new insights into the clinical penetrance of hereditary hemochromatosis, the development of non-immunosuppressive cyclosporin A analogs for the treatment of chronic hepatitis C, thrombopoietin receptor agonists for thrombocytopenia in cirrhosis, the development of vasopressin V2 receptor antagonists (vaptans) for the management of ascites and hyponatremia in portal hypertension, the description of chronic hepatitis E in immunosuppressed patients, and the development of sorafenib as the first molecularly targeted therapy with a demonstrated benefit in the treatment of advanced hepatocellular carcinoma...
January 21, 2009: Revue Médicale Suisse
M P Thornton, S S Marven, M S Tanner, B Gürtl-Lackner
We describe, to our knowledge, the first case of progressive neonatal liver failure due to neonatal haemochromatosis (NH) occurring in an infant with a gastroschisis and review the literature regarding these two conditions. A 1,665 g male infant with antenatally diagnosed gastroschisis was born with a severe coagulopathy, anaemia, thrombocytopenia, hypoglycaemia and jaundice. He developed progressive liver failure, complicated by necrotising enterocolitis. Serum ferritin was elevated at 1,459 microg/L. He died on day 40 and a limited post-mortem examination confirmed significant hepatic siderosis with fibrosis and cholestasis, and siderosis of the pancreas...
May 2008: Pediatric Surgery International
Leon Fisher, Alexander Fisher
BACKGROUND & AIMS: The liver plays a central role in vitamin D metabolism. Our aim was to determine the prevalence and type of vitamin D-parathyroid hormone (PTH) disturbance in ambulatory patients with noncholestatic chronic liver disease (CLD) and its relationship with disease severity and liver function. METHODS: We studied 100 consecutive outpatients (63 men, 37 women; mean age, 49.0 +/- 12.1 [SD] y) with noncholestatic CLD caused by alcohol (n = 40), hepatitis C (n = 38), hepatitis B (n = 12), autoimmune hepatitis (n = 4), hemochromatosis (n = 4), and nonalcoholic steatohepatitis (n = 2); 51 patients had cirrhosis...
April 2007: Clinical Gastroenterology and Hepatology
Nancy C Andrews, Sudha Anupindi, Kamran Badizadegan
Presentation of Case. A four-week-old male infant was admitted to this hospital because of jaundice, hyperbilirubinemia, thrombocytopenia, and abdominal distention. The patient was born at term at another hospital by spontaneous vaginal delivery to a 37-year-old woman (gravida 2, para 2) after an..
July 14, 2005: New England Journal of Medicine
M Eisold, S Gehrke, W Stremmel, R Gugler
HISTORY: A 28 year young female presented to our hospital for further evaluation with recently diagnosed diabetes mellitus, hyperpigmentation of the skin, hepato- and splenomegaly, thrombocytopenia and an elevated transferrin saturation (96 %), but a negative test for HFE gene mutations such as C282Y and H63D. FINDINGS: Using the mini-laparascopic technique we diagnosed a smallnodular liver cirrhosis with an iron overload. DIAGNOSIS AND TREATMENT: This is the clinical presentation of one subtype of the so called Non-HFE-hemochromatosis, the juvenile hemochromatosis (HFE2)...
June 17, 2005: Deutsche Medizinische Wochenschrift
Kevin P O'Boyle, Ashwin Murigeppa, Dharamvir Jain, Leonard Dauber, Janice P Dutcher, Peter H Wiernik
A 69-yr-old male with a history of familial hemochromatosis and status after liver transplantation was found to have severe thrombocytopenia (platelet count of 8000/microL). He was also anemic and was diagnosed with acute myeloid leukemia (AML) after a bone marrow biopsy. He was started on gemtuzumab ozogamicin (Mylotarg) and developed hepatic and multiorgan failure consistent with veno-occlusive disease within 2 wk. He did not have a history of hematopoietic stem cell transplantation, which is usually the case in AML patients who develop veno-occlusive disease of the liver after treatment with Mylotarg...
2003: Medical Oncology
No abstract text is available yet for this article.
October 8, 1964: La Semaine des Hôpitaux: Organe Fondé Par L'Association D'enseignement Médical des Hôpitaux de Paris
Robert T Muldoon, Mary Lowery Nordberg, Richard L Martinez, Maureen Heldmann, Richard P Mansour, Diana M Veillon, James D Cotelingam
No abstract text is available yet for this article.
September 2002: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
J Romagnuolo, G S Jhangri, L D Jewell, V G Bain
OBJECTIVE: Liver biopsy is believed to be necessary before antiviral treatment in hepatitis C. Studies have found symptoms and biochemistry poorly predictive of grade and stage. In practice, a combination of factors is used to anticipate histology. The aim of this study is to evaluate the ability of global clinical assessment to predict histology in hepatitis C. METHODS: Fifty-four consecutive patients referred to a university center for consideration of antiviral therapy were enrolled...
November 2001: American Journal of Gastroenterology
G P Schechter, H P Dave, B M Alving
No abstract text is available yet for this article.
January 2, 2001: Annals of Internal Medicine
R Berent, S Allinger, W Höbling, J Auer, P Knoflach
HISTORY AND CLINICAL FINDINGS: A 24 year old yugoslavian father of two children, complained of decreased libido and impotence since seven months. He also described recurrent joint pains in the knees and wrist joints. The urological and internal examination was unremarkable. INVESTIGATIONS: Except for slightly elevated liver enzymes and a mild thrombocytopenia the laboratory tests were normal. Testosteron, follicle stimulating hormone and luteinizing hormone concentrations were markedly decreased...
December 1, 2000: Deutsche Medizinische Wochenschrift
W Stremmel
Primary hemochromatosis is characterized by a specific pattern of clinical manifestations. It includes liver disease with hepatomegaly, glucose intolerance, e.g. diabetes, hyperpigmentation oft the skin, impotence/ amenorrhea, arthropathy, cardiomyopathy and fatigue. Laboratory investigation reveals significantly elevated serum ferritin and transferrin saturation with iron. The diagnosis is confirmed by liver biopsy and quantitative determination of elevated liver iron content. Wilson's disease represents a copper storage disease...
November 19, 1996: Praxis
J A McLean, H A Luke
No abstract text is available yet for this article.
January 11, 1969: Medical Journal of Australia
J P Kushner, G R Lee, M M Wintrobe, G E Cartwright
No abstract text is available yet for this article.
May 1971: Medicine (Baltimore)
D J Straus
No abstract text is available yet for this article.
July 1973: Seminars in Hematology
M A Habib, R A Burningham
No abstract text is available yet for this article.
1973: Scandinavian Journal of Haematology
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