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https://www.readbyqxmd.com/read/29237835/hla-class-i-mediated-hiv-1-control-in-vietnamese-infected-with-hiv-1-subtype-a-e
#1
Takayuki Chikata, Giang Van Tran, Hayato Murakoshi, Tomohiro Akahoshi, Ying Qi, Vivek Naranbhai, Nozomi Kuse, Yoshiko Tamura, Madoka Koyanagi, Sachiko Sakai, Dung Hoai Nguyen, Dung Thi Nguyen, Ha Thu Nguyen, Trung Vu Nguyen, Shinichi Oka, Maureen P Martin, Mary Carrington, Keiko Sakai, Kinh Van Nguyen, Masafumi Takiguchi
HIV-1-specific cytotoxic T cells (CTLs) play an important role in the control of HIV-1 subtype B or C infection. However, the role of CTLs in HIV-1 subtype A/E infection still remains unclear. Here we investigated the association of HLA class I alleles with clinical outcome in treatment-naïve Vietnamese infected with subtype A/E. We found that HLA-C*12:02 was significantly associated with lower pVL and higher CD4 count and that the HLA-A*29:01-B*07:05-C*15:05 haplotype was significantly associated with higher pVL and lower CD4 count as compared to individuals without these respective genotypes...
December 13, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29212477/nurse-health-and-lifestyle-modification-versus-standard-care-in-40-to-70-year-old-regional-adults-study-protocol-of-the-management-to-optimise-diabetes-and-metabolic-syndrome-risk-reduction-via-nurse-led-intervention-modern-randomized-controlled-trial
#2
Melinda J Carrington, Paul Zimmet
BACKGROUND: Metabolic syndrome (MetS), the clustering of multiple leading risk factors, predisposes individuals to increased risk for developing type 2 diabetes and/or cardiovascular disease (CVD). Cardio-metabolic disease risk increases with greater remoteness where specialist services are scarce. Nurse-led interventions are effective for the management of chronic disease. The aim of this clinical trial is to determine whether a nurse-implemented health and lifestyle modification program is more beneficial than standard care to reduce cardio-metabolic abnormalities and future risk of CVD and diabetes in individuals with MetS...
December 6, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29212346/palliative-care-providers-practices-surrounding-psychological-distress-screening-and-treatment-a-national-survey
#3
Elissa Kozlov, Claude Eghan, Sheila Moran, Keela Herr, M Carrington Reid
OBJECTIVE: To investigate how inpatient palliative care teams nationwide currently screen for and treat psychological distress. METHODS: A web-based survey was sent to inpatient palliative care providers of all disciplines nationwide asking about their practice patterns regarding psychological assessment and treatment. Descriptive statistics were used to characterize the sample and responses, and analysis of variance was conducted to determine whether certain disciplines were more likely to utilize specific treatment modalities...
January 1, 2017: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29194338/nurses-use-of-positive-deviance-when-encountering-electronic-health-records-related-unintended-consequences
#4
Alycia A Bristol, Christine W Nibbelink, Sheila M Gephart, Jane M Carrington
As organizations adopt electronic health records (EHRs), nurses frequently encounter system barriers and difficulty performing role expectations. This article describes nurses' experiences with unintended consequences emerging from the use of an EHR. In some situations, nurses were positively deviant when encountering unintended consequences relating to EHRs to accomplish patient care or protect patient safety. Nurses engaged in work-arounds to provide patient care when the EHR did not meet their needs, sometimes in positively deviant ways...
January 2018: Nursing Administration Quarterly
https://www.readbyqxmd.com/read/29194056/neonatal-nurses-experience-unintended-consequences-and-risks-to-patient-safety-with-electronic-health-records
#5
Katherine M Dudding, Sheila M Gephart, Jane M Carrington
In this article, we examine the unintended consequences of nurses' use of electronic health records. We define these as unforeseen events, change in workflow, or an unanticipated result of implementation and use of electronic health records. Unintended consequences experienced by nurses while using electronic health records have been well researched. However, few studies have focused on neonatal nurses, and it is unclear to what extent unintended consequences threaten patient safety. A new instrument called the Carrington-Gephart Unintended Consequences of Electronic Health Record Questionnaire has been validated, and secondary analysis using the tool explored the phenomena among neonatal nurses (N = 40)...
November 30, 2017: Computers, Informatics, Nursing: CIN
https://www.readbyqxmd.com/read/29191016/room-temperature-mid-infrared-emission-from-faceted-inassb-multi-quantum-wells-embedded-in-inas-nanowires
#6
Aiyeshah Alhodaib, Yasir Noori, Peter J Carrington, Ana M Sanchez, Michael Dermot Thompson, Robert J Young, Anthony Krier, Andrew Marshall
There is considerable interest in the development of InAsSb based nanowires for infrared photonics due to their high tunability across the infrared spectral range, high mobility and integration with silicon electronics. However, optical emission is currently limited to low temperatures due to strong non-radiative Auger and surface recombination. Here, we present a new structure based on conical type II InAsSb/InAs multi-quantum wells within InAs nanowires which exhibit bright mid-infrared photoluminescence up to room temperature...
November 30, 2017: Nano Letters
https://www.readbyqxmd.com/read/29167337/differential-immunodominance-hierarchy-of-cd8-t-cell-responses-in-hla-b-27-05-and-b-27-02-mediated-control-of-hiv-1-infection
#7
Emily Adland, Matilda Hill, Nora Lavandier, Anna Csala, Anne Edwards, Fabian Chen, Marek Radkowski, Justyna D Kowalska, Dimitrios Paraskevis, Angelos Hatzakis, Humberto Valenzuela-Ponce, Katja Pfafferott, Ian Williams, Pierre Pellegrino, Persephone Borrow, Masahiko Mori, Jürgen Rockstroh, Julia G Prado, Beatriz Mothe, Judith Dalmau, Javier Martinez-Picado, Gareth Tudor-Williams, John Frater, Anette Stryhn, Soren Buus, Gustavo Reyes Teran, Simon Mallal, Mina John, Susan Buchbinder, Gregory Kirk, Jeffrey Martin, Nelson Michael, Jacques Fellay, Steve Deeks, Bruce Walker, Santiago Avila-Rios, David Cole, Christian Brander, Mary Carrington, Philip Goulder
The well-characterised association between HLA-B*27:05 and protection against HIV disease progression has been linked to immunodominant HLA-B*27:05-restricted CD8+ T-cell responses towards the conserved Gag 263-272 ('KK10') and Pol 901-909 'KY9' epitopes. We here studied the impact of the 3 amino acid differences between HLA-B*27:05 and the closely-related HLA-B*27:02 on the HIV-specific CD8+ T-cell response hierarchy and on immune control of HIV. Genetic epidemiological data indicate that both HLA-B*27:02 and HLA-B*27:05 associate with slower disease progression and lower viral loads...
November 22, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29166769/economic-evaluation-of-a-nurse-led-home-and-clinic-based-secondary-prevention-programme-to-prevent-progressive-cardiac-dysfunction-in-high-risk-individuals-the-nurse-led-intervention-for-less-chronic-heart-failure-nil-chf-randomized-controlled-study
#8
Shoko Maru, Joshua Byrnes, Melinda J Carrington, Yih-Kai Chan, Simon Stewart, Paul A Scuffham
OBJECTIVE: The objective of this study was to assess the cost-effectiveness of a long-term, nurse-led, multidisciplinary programme of home/clinic visits in preventing progressive cardiac dysfunction in patients at risk of developing de novo chronic heart failure (CHF). METHODS: A trial-based analysis was conducted alongside a pragmatic, single-centre, open-label, randomized controlled trial of 611 patients (mean age: 66 years) with subclinical cardiovascular diseases (without CHF) discharged to home from an Australian tertiary referral hospital...
November 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29156171/the-use-of-decellularized-human-placenta-in-full-thickness-wound-repair-and%C3%A2-periarticular-soft-tissue-reconstruction-an-update-on-regenerative-healing
#9
REVIEW
Stephen A Brigido, Scott C Carrington, Nicole M Protzman
Prolonged or incomplete healing of the foot and ankle can pose significant challenges. Therefore, investigators have begun searching for alternative treatment strategies. With advances in tissue engineering, decellularized human placental connective tissue matrix has been suggested as a means to achieve more rapid and complete healing for various soft tissue and bone procedures. Basic science and clinical studies have shown that decellularized human placental connective tissue matrix can support regenerative healing through cellular migration, accelerated tissue remodeling, and the establishment of functional tissue...
January 2018: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/29105735/research-directions-in-genetic-predispositions-to-stevens-johnson-syndrome-toxic-epidermal-necrolysis
#10
Teri A Manolio, Carolyn M Hutter, Mark Avigan, Ricardo Cibotti, Robert L Davis, Joshua C Denny, Lois La Grenade, Lisa M Wheatley, Mary N Carrington, Wasun Chantratita, Wen-Hung Chung, Andrea D Dalton, Shuen-Iu Hung, Ming Ta Michael Lee, J Steven Leeder, Juan J L Lertora, Surakameth Mahasirimongkol, Howard L McLeod, Maja Mockenhaupt, Michael Pacanowski, Elizabeth J Phillips, Simone Pinheiro, Munir Pirmohamed, Cynthia Sung, Wimon Suwankesawong, Lauren Trepanier, Santa J Tumminia, David Veenstra, Rika Yuliwulandari, Neil H Shear
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is one of the most devastating of adverse drug reactions (ADRs) and was, until recently, essentially unpredictable. With the discovery of several risk alleles for drug-induced SJS/TEN and the demonstration of effectiveness of screening in reducing incidence, the stage is set for implementation of preventive strategies in populations at risk. Yet much remains to be learned about this potentially fatal complication of commonly used drugs.
November 6, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29102102/bluetongue-virus-infection-in-na%C3%A3-ve-cattle-identification-of-circulating-serotypes-and-associated-culicoides-biting-midge-species-in-trinidad
#11
T Brown-Joseph, C Batten, L E Harrup, L Frost, J Flannery, H Hicks, V Ramkissoon, R Ramdeen, C V Carrington, C A L Oura
To better understand risks associated with trading cattle, it is important to know which serotypes of Bluetongue virus (BTV) are circulating within the exporting and importing country. Hence, this study was conducted to identify the circulating serotypes of BTV in Trinidad. Blood samples were collected monthly from sixty BTV- naïve imported cattle over a six month period after their arrival in the country. Virological (PCR and virus isolation) and serological (ELISA) analyses were carried out on the samples and CDC light traps were placed near the cattle enclosure to trap and identify the species of Culicoides biting midges that were present...
November 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29098504/examining-hpv-and-hpv-vaccine-related-cognitions-and-acceptability-among-us-born-and-immigrant-hispanics-and-us-born-and-immigrant-non-hispanic-blacks-a-preliminary-catchment-area-study
#12
Kimlin Tam Ashing, Agatha Carrington, Camille Ragin, Veronica Roach
PURPOSE: Disparities in HPV vaccination exist. Therefore, we investigated the distinction and disparities in HPV- and HPV vaccine-related cognitions and acceptability among US-born African Americans (AA) and Black immigrants, and between US-born Latinas and Latina immigrants. METHODS: Secondary data analyses were conducted with 383 female adults divided into non-Hispanic Blacks-(1) AA born in the US (n = 129) and (2) Black immigrants (n = 53), and Hispanics-(3) Latinas born in the US (n = 57) and (4) Latina immigrants (n = 144)...
November 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29065174/glucagon-like-receptor-1-glucagon-dual-agonist-acutely-enhanced-hepatic-lipid-clearance-and-suppressed-de-novo-lipogenesis-in-mice
#13
Vijay R More, Julie Lao, David G McLaren, Anne-Marie Cumiskey, Beth Ann Murphy, Ying Chen, Stephen Previs, Steven Stout, Rajesh Patel, Santhosh Satapati, Wenyu Li, Edward Kowalik, Daphne Szeto, Andrea Nawrocki, Alessandro Pocai, Liangsu Wang, Paul Carrington
Lipid lowering properties of glucagon have been reported. Blocking glucagon signaling leads to rise in plasma LDL levels. Here, we demonstrate the lipid lowering effects of acute dosing with Glp1r/Gcgr dual agonist (DualAG). All the experiments were performed in 25 week-old male diet-induced (60% kCal fat) obese mice. After 2 hrs of fasting, mice were injected subcutaneously with vehicle, liraglutide (25nmol/kg) and DualAG (25nmol/kg). De novo cholesterol and palmitate synthesis was measured by deuterium incorporation method using D2O...
2017: PloS One
https://www.readbyqxmd.com/read/29055006/posttranscriptional-regulation-of-hla-a-protein-expression-by-alternative-polyadenylation-signals-involving-the-rna-binding-protein-syncrip
#14
Smita Kulkarni, Veron Ramsuran, Marijana Rucevic, Sukhvinder Singh, Alexandra Lied, Viraj Kulkarni, Colm O'hUigin, Sylvie Le Gall, Mary Carrington
Genomic variation in the untranslated region (UTR) has been shown to influence HLA class I expression level and associate with disease outcomes. Sequencing of the 3'UTR of common HLA-A alleles indicated the presence of two polyadenylation signals (PAS). The proximal PAS is conserved, whereas the distal PAS is disrupted within certain alleles by sequence variants. Using 3'RACE, we confirmed expression of two distinct forms of the HLA-A 3'UTR based on use of either the proximal or the distal PAS, which differ in length by 100 bp...
October 20, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29053226/cover-image-volume-173a-number-11-november-2017
#15
Cristina M Justice, Jinoh Kim, Sun-Don Kim, Kyunhgho Kim, Garima Yagnik, Araceli Cuellar, Blake Carrington, Chung-Ling Lu, Raman Sood, Simeon A Boyadjiev, Alexander F Wilson
The cover image, by Cristina M. Justice et al., is based on the Original Article A Variant Associated with Sagittal Nonsydromic Craniosynostosis Alters the Regulatory Function of a Non-Coding Element, DOI: 10.1002/ajmg.a.38392. Photo Credit: Blake Carrington (NIH/NHGRI).
November 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29044097/dna-binding-of-the-tet-transactivator-curtails-antigen-induced-lymphocyte-activation-in-mice
#16
Eleonora Ottina, Victor Peperzak, Katia Schoeler, Emma Carrington, Roswitha Sgonc, Marc Pellegrini, Simon Preston, Marco J Herold, Andreas Strasser, Andreas Villunger
The Tet-On/Off system for conditional transgene expression constitutes state-of-the-art technology to study gene function by facilitating inducible expression in a timed and reversible manner. Several studies documented the suitability and versatility of this system to trace lymphocyte fate and to conditionally express oncogenes or silence tumour suppressor genes in vivo. Here, we show that expression of the tetracycline/doxycycline-controlled Tet-transactivator, while tolerated well during development and in immunologically unchallenged animals, impairs the expansion of antigen-stimulated T and B cells and thereby curtails adaptive immune responses in vivo...
October 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/29034259/problem-adaptation-therapy-for-pain-path-pain-a-psychosocial-intervention-for-older-adults-with-chronic-pain-and-negative-emotions-in-primary-care
#17
Dimitris N Kiosses, Lisa D Ravdin, Amy Stern, Ruth Bolier, Cara Kenien, M Carrington Reid
Chronic pain is highly prevalent in older adults, contributes to activity restriction and social isolation, disrupts family and interpersonal relationships, and poses a significant economic burden to society. Negative emotions such as sadness, anxiety, helplessness, and hopelessness are associated with chronic pain and contribute to poor quality of life, impaired interpersonal and social functioning, and increased disability. Psychosocial interventions for older adults with chronic pain have been historically developed for, and are almost exclusively delivered to, cognitively intact patients...
2017: Geriatrics
https://www.readbyqxmd.com/read/29033282/character-strengths-of-individuals-with-first-episode-psychosis-in-individual-resiliency-training
#18
Julia Browne, Sue E Estroff, Kelsey Ludwig, Carrington Merritt, Piper Meyer-Kalos, Kim T Mueser, Jennifer D Gottlieb, David L Penn
Positive psychology interventions that integrate a person's strengths into treatment result in improvements in life satisfaction and well-being. Character strengths classified within six core virtues (wisdom/knowledge, courage, humanity, justice, temperance, and transcendence) have been the subject of substantial research. Though a number of studies have been conducted in the general population, little is known about the character strengths of individuals with first episode psychosis (FEP). Moreover, positive psychology principles, in particular a focus on personal strengths, have been increasingly integrated into FEP treatment and was a core component of Individual Resiliency Training (IRT), the individual therapy component of NAVIGATE tested in the Recovery After an Initial Schizophrenia Episode Early Treatment Program...
October 12, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29031264/computing-vibrational-energy-levels-of-ch4-with-a-smolyak-collocation-method
#19
Gustavo Avila, Tucker Carrington
In this paper, we demonstrate that it is possible to apply collocation to compute vibrational energy levels of a five-atom molecule using an exact kinetic energy operator (with cross terms and coordinate-dependent coefficients). This is made possible by using (1) a pruned basis of products of univariate functions; (2) a Smolyak grid made from nested sequences of grids for each coordinate; (3) a collocation method that obviates the need to solve a generalized eigenvalue problem; (4) an efficient sequential transformation between the (nondirect product) grid and the (nondirect product) basis representations; and (5) hierarchical univariate functions that make it possible to avoid storing large intermediate vectors...
October 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29024857/controlled-trial-evaluation-of-exposure-duration-to-negative-air-ions-for-the-treatment-of-seasonal-affective-disorder
#20
Bonnie Bowers, Randall Flory, Joseph Ametepe, Lauren Staley, Anne Patrick, Heather Carrington
This study evaluated the effectiveness of 30 or 60min of daily exposure to high-density or to zero-density (placebo condition) negative air ions over 18 days on the symptoms of seasonal affective disorder (SAD) in 40 participants under controlled laboratory conditions. Exposure to high-density negative air ions was superior to zero-density negative air ions in alleviating depression and the atypical symptoms of SAD. Also, more subjects in the high-density negative air ions groups met two different clinical response criteria than did those in the zero-density groups...
August 19, 2017: Psychiatry Research
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