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https://www.readbyqxmd.com/read/28531281/standard-vs-intensified-management-of-heart-failure-to-reduce-healthcare-costs-results-of-a-multicentre-randomized-controlled-trial
#1
P A Scuffham, J Ball, J D Horowitz, C Wong, P J Newton, P Macdonald, J McVeigh, A Rischbieth, N Emanuele, M J Carrington, C M Reid, Y K Chan, S Stewart
Aims: To determine if an intensified form of heart failure management programme (INT-HF-MP) based on individual profiling is superior to standard management (SM) in reducing health care costs during 12-month follow-up (primary endpoint). Methods and results: A multicentre randomized trial involving 787 patients (full analysis set) discharged from four tertiary hospitals with chronic HF who were randomized to SM (n = 391) or INT-HF-MP (n = 396). Mean age was 74 ± 12 years, 65% had HF with a reduced ejection fraction (31...
May 20, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28527461/systematically-expanding-nondirect-product-bases-within-the-pruned-multi-configuration-time-dependent-hartree-mctdh-method-a-comparison-with-multi-layer-mctdh
#2
Robert Wodraszka, Tucker Carrington
We propose a pruned multi-configuration time-dependent Hartree (MCTDH) method with systematically expanding nondirect product bases and use it to solve the time-independent Schrödinger equation. No pre-determined pruning condition is required to select the basis functions. Using about 65 000 basis functions, we calculate the first 69 vibrational eigenpairs of acetonitrile, CH3CN, to an accuracy better than that achieved in a previous pruned MCTDH calculation which required more than 100 000 basis functions...
May 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28523387/seroprevalence-of-economically-important-viral-pathogens-in-swine-populations-of-trinidad-and-tobago-west-indies
#3
Jamie R V Sookhoo, Arianne Brown-Jordan, Lemar Blake, Ridley B Holder, Sharon M Brookes, Stephen Essen, Christine V F Carrington, Ian H Brown, Christopher A L Oura
The objective of this study was to evaluate the seroprevalence and identify the strains of swine influenza virus (SwIV), as well as the seroprevalence of porcine parvovirus (PPV), transmissible gastroenteritis virus (TGEV), porcine reproductive and respiratory syndrome virus (PRRSV), porcine respiratory coronavirus (PRCV), porcine circovirus type 2 (PCV-2), and classical swine fever virus (CSFV) in pigs in Trinidad and Tobago (T&T). Blood samples (309) were randomly collected from pigs at farms throughout T&T...
May 18, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28486816/attitudes-towards-exercise-among-substance-using-older-adults-living-with-hiv-and-chronic-pain
#4
Annie L Nguyen, Jordan E Lake, M Carrington Reid, Suzette Glasner, Jessica Jenkins, Jury Candelario, Sarah Soliman, Homero E Del Pino, Alison A Moore
Chronic pain and substance use disorders occur commonly among HIV-infected persons. Recent CDC guidelines recommend non-pharmacologic approaches over opioid medications for the management of chronic pain. This is particularly relevant for persons with substance use disorders. Structured physical activity may be an effective strategy for pain reduction. We developed a combined cognitive-behavioral therapy (CBT) + exercise intervention to reduce pain, pain-related disability and substance use and improve physical function in older HIV-infected adults with chronic pain and substance use...
May 9, 2017: AIDS Care
https://www.readbyqxmd.com/read/28486054/beyond-the-page-a-process-review-of-using-ethnodrama-to-disseminate-research-findings
#5
Jamilah Taylor, Emily Namey, Annette Carrington Johnson, Greg Guest
Public health researchers are charged with communicating study findings to appropriate audiences. Dissemination activities typically target the academic research community. However, as participatory research grows, researchers are increasingly exploring innovative dissemination techniques to reach broader audiences, particularly research participants and their communities. One technique is ethnodrama/ethnotheatre, a written or live performance based on study findings. Though used effectively in social change programs, dramas are seldom used to distribute research findings exclusively...
May 9, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28480053/understanding-the-evolution-and-spread-of-chikungunya-virus-in-the-americas-using-complete-genome-sequences
#6
N S D Sahadeo, O M Allicock, P M De Salazar, A J Auguste, S Widen, B Olowokure, C Gutierrez, A M Valadere, K Polson-Edwards, S C Weaver, C V F Carrington
Local transmission of chikungunya virus (CHIKV) was first detected in the Americas in December 2013, after which it spread rapidly throughout the Caribbean islands and American mainland, causing a major chikungunya fever epidemic. Previous phylogenetic analysis of CHIKV from a limited number of countries in the Americas suggests that an Asian genotype strain was responsible, except in Brazil where both Asian and East/Central/South African (ECSA) lineage strains were detected. In this study, we sequenced thirty-three complete CHIKV genomes from viruses isolated in 2014 from fourteen Caribbean islands, the Bahamas and two mainland countries in the Americas...
January 2017: Virus Evolution
https://www.readbyqxmd.com/read/28473698/implantable-strain-sensor-to-monitor-fracture-healing-with-standard-radiography
#7
Hunter Pelham, Donald Benza, Paul W Millhouse, Nathan Carrington, Md Arifuzzaman, Caleb J Behrend, Jeffrey N Anker, John D DesJardins
Current orthopaedic clinical methods do not provide an objective measure of fracture healing or weight bearing for lower extremity fractures. The following report describes a novel approach involving in-situ strain sensors to objectively measure fracture healing. The sensor uses a cantilevered indicator pin that responds to plate bending and an internal scale to demonstrate changes in the pin position on plain film radiographs. The long lever arm amplifies pin movement compared to interfragmentary motion, and the scale enables more accurate measurement of position changes...
May 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28449009/the-prognostic-value-of-dynamic-contrast-enhanced-mri-contrast-agent-transfer-constant-k-trans-in-cervical-cancer-is-explained-by-plasma-flow-rather-than-vessel-permeability
#8
Ben R Dickie, Chris J Rose, Lucy E Kershaw, Stephanie B Withey, Bernadette M Carrington, Susan E Davidson, Gillian Hutchison, Catharine M L West
BACKGROUND: The microvascular contrast agent transfer constant K(trans) has shown prognostic value in cervical cancer patients treated with chemoradiotherapy. This study aims to determine whether this is explained by the contribution to K(trans) of plasma flow (Fp), vessel permeability surface-area product (PS), or a combination of both. METHODS: Pre-treatment dynamic contrast-enhanced MRI (DCE-MRI) data from 36 patients were analysed using the two-compartment exchange model...
May 23, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28442184/pigmented-villonodular-synovitis-of-the-knee-a-retrospective-analysis-of-214-cases-at-a-uk-tertiary-referral-centre
#9
K H Patel, P D Gikas, R C Pollock, R W Carrington, S R Cannon, J A Skinner, T W Briggs, W J S Aston
AIMS: Pigmented villonodular synovitis (PVNS) is a rare, locally aggressive and potentially recurrent synovial disease. We present the largest single-centre experience of knee PVNS. Our aim was to evaluate our tertiary hospital's experience in the management of knee PVNS. PATIENTS AND METHODS: Retrospective data collection of consecutive cases of knee PVNS from 2002 to 2015. RESULTS: In total, 214 cases of knee PVNS were identified which represented 53...
April 22, 2017: Knee
https://www.readbyqxmd.com/read/28429320/euglena-gracilis-genome-and-transcriptome-organelles-nuclear-genome-assembly-strategies-and-initial-features
#10
ThankGod Echezona Ebenezer, Mark Carrington, Michael Lebert, Steven Kelly, Mark C Field
Euglena gracilis is a major component of the aquatic ecosystem and together with closely related species, is ubiquitous worldwide. Euglenoids are an important group of protists, possessing a secondarily acquired plastid and are relatives to the Kinetoplastidae, which themselves have global impact as disease agents. To understand the biology of E. gracilis, as well as to provide further insight into the evolution and origins of the Kinetoplastidae, we embarked on sequencing the nuclear genome; the plastid and mitochondrial genomes are already in the public domain...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28401883/cognate-antigen-engagement-on-parenchymal-cells-stimulates-cd8-t-cell-proliferation-in-situ
#11
Robyn M Sutherland, Sarah L Londrigan, Jamie L Brady, Emma M Carrington, Julia M Marchingo, Susanne Heinzel, Philip D Hodgkin, Kate L Graham, Thomas W Kay, Yifan Zhan, Andrew M Lew
T-cell responses are initiated upon cognate presentation by professional antigen presenting cells in lymphoid tissue. T cells then migrate to inflamed tissues, but further T-cell stimulation in these parenchymal target sites is not well understood. Here we show that T-cell expansion within inflamed tissues is a distinct phase that is neither a classical primary nor classical secondary response. This response, which we term 'the mezzanine response', commences within days after initial antigen encounter, unlike the secondary response that usually occurs weeks after priming...
April 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/28388099/perspective-computing-ro-vibrational-spectra-of-molecules-with-more-than-four-atoms
#12
Tucker Carrington
In this perspective, I review methods for computing (ro-)vibrational energy levels and wavefunctions of molecules with more than four atoms. I identify three problems one confronts (1) reducing the size of the basis; (2) computing hundreds of eigenvalues and eigenvectors of a large matrix; (3) calculating matrix elements of the potential, and present ideas that mitigate them. Most modern methods use a combination of these ideas. I divide popular methods into groups based on the strategies used to deal with the three problems...
March 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28381627/characterization-of-rbp9-and-rbp10-two-developmentally-regulated-rna-binding-proteins-in-trypanosoma-brucei
#13
Luis Miguel De Pablos, Steve Kelly, Janaina de Freitas Nascimento, Jack Sunter, Mark Carrington
The fate of an mRNA is determined by its interaction with proteins and small RNAs within dynamic complexes called ribonucleoprotein complexes (mRNPs). In Trypanosoma brucei and related kinetoplastids, responses to internal and external signals are mainly mediated by post-transcriptional processes. Here, we used proximity-dependent biotin identification (BioID) combined with RNA-seq to investigate the changes resulting from ectopic expression of RBP10 and RBP9, two developmentally regulated RNA-binding proteins (RBPs)...
April 2017: Open Biology
https://www.readbyqxmd.com/read/28378721/synthesis-and-structures-of-photoactive-manganese-carbonyl-complexes-derived-from-2-pyridin-2-yl-1-3-benzothiazole-and-2-quinolin-2-yl-1-3-benzothiazole
#14
Jenny Stenger-Smith, Indranil Chakraborty, Samantha Carrington, Pradip Mascharak
PhotoCORMs (photo-active CO-releasing molecules) have emerged as a class of CO donors where the CO release process can be triggered upon illumination with light of appropriate wavelength. We have recently reported an Mn-based photoCORM, namely [MnBr(pbt)(CO)3] [pbt is 2-(pyridin-2-yl)-1,3-benzothiazole], where the CO release event can be tracked within cellular milieu by virtue of the emergence of strong blue fluorescence. In pursuit of developing more such trackable photoCORMs, we report herein the syntheses and structural characterization of two Mn(I)-carbonyl complexes, namely fac-tricarbonylchlorido[2-(pyridin-2-yl)-1,3-benzothiazole-κ(2)N,N']manganese(I), [MnCl(C12H8N2S)(CO)3], (1), and fac-tricarbonylchlorido[2-(quinolin-2-yl)-1,3-benzothiazole-κ(2)N,N']manganese(I), [MnCl(C16H10N2S)(CO)3], (2)...
April 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/28371406/in-vitro-generation-of-polysialylated-cervical-mucins-by-bacterial-polysialyltransferases-to-counteract-cytotoxicity-of-extracellular-histones
#15
Sebastian P Galuska, Christina E Galuska, Tharmala Tharmalingam, Kristina Zlatina, Gerlinde Prem, Farzali C O Husejnov, Pauline M Rudd, Willie F Vann, Colm Reid, Justine Vionnet, Mary E Gallagher, Faye A Carrington, Sarah-Louise Hassett, Stephen D Carrington
Neutrophil extracellular traps (NET) are formed against pathogens. However, various diseases are directly linked to this meshwork of DNA. The cytotoxic properties of extracellular histones especially seem to be an important trigger during these diseases. Furthermore, NET accumulation on implants is discussed to result in an impaired efficiency or failure, depending on the category of implant. Interestingly, mucins have been investigated as surface coatings potentially capable of reducing neutrophil adhesion...
March 31, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28363776/facilitating-trypanosome-imaging
#16
Marius Glogger, Ines Subota, Anna Pezzarossa, Anna-Lena Denecke, Mark Carrington, Susanne F Fenz, Markus Engstler
Research on trypanosomes as a model organism has provided a substantial contribution to a detailed understanding of basic cellular processes within the last few years. At the same time, major advances in super-resolution microscopy have been achieved, facilitating the resolution of biological structures in living cells at a scale of a few nm. However, the motility of trypanosomes has prevented access to high resolution microscopy of live cells. Here, we present a hydrogel based on poly(ethylene glycol) functionalized with either norbornene or thiol moieties for UV induced thiol-ene crosslinking for the embedding and imaging of live trypanosomes...
March 28, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28362427/anti-apoptotic-proteins-bcl-2-mcl-1-and-a1-summate-collectively-to-maintain-survival-of-immune-cell-populations-both-in-vitro-and-in-vivo
#17
Emma M Carrington, Yifan Zhan, Jamie L Brady, Jian-Guo Zhang, Robyn M Sutherland, Natasha S Anstee, Robyn L Schenk, Ingela B Vikstrom, Rebecca B Delconte, David Segal, Nicholas D Huntington, Philippe Bouillet, David M Tarlinton, David Cs Huang, Andreas Strasser, Suzanne Cory, Marco J Herold, Andrew M Lew
Survival of various immune cell populations has been proposed to preferentially rely on a particular anti-apoptotic BCL-2 family member, for example, naive T cells require BCL-2, while regulatory T cells require MCL-1. Here we examined the survival requirements of multiple immune cell subsets in vitro and in vivo, using both genetic and pharmacological approaches. Our findings support a model in which survival is determined by quantitative participation of multiple anti-apoptotic proteins rather than by a single anti-apoptotic protein...
May 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28339327/raising-public-awareness-of-clinical-trials-development-of-messages-for-a-national-health-communication-campaign
#18
Holly A Massett, David M Dilts, Robert Bailey, Jennifer Berktold, Rebecca Ledsky, Nancy L Atkinson, Grace Mishkin, Andrea Denicoff, Rose Mary Padberg, Marin P Allen, Karen Silver, Kelli Carrington, Lenora E Johnson
Clinical trials are essential for developing new and effective treatments and improving patient quality of life; however, many trials cannot answer their primary research questions because they fall short of their recruitment goals. This article reports the results of formative research conducted in two populations, the public and primary care physicians, to identify messages that may raise awareness and increase interest in clinical trials and be used in a national communication campaign. Results suggested that participants were primarily motivated to participate in clinical trials out of a self-interest to help themselves first...
May 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28324867/blood-glucose-levels-and-glycaemic-burden-in-76-341-patients-attending-primary-care-bittersweet-findings-from-a-9-year-cohort-study
#19
Melinda J Carrington, Neale Cohen, Joshua F Wiley
AIMS: Diabetes care is principally applied in the primary care setting whereby we examined trends in glycaemic levels and goals and estimated avoidable glycaemic burden. METHODS: We retrieved glycated haemoglobin (HbA1C) results and glucose-lowering prescription records from a patient-based medical database during 2005-2013. There were 275,480 available HbA1C measurements from 76,341 individuals managed by 960 general practitioners from 321 clinics across Australia...
February 27, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28298098/using-monomer-vibrational-wavefunctions-as-contracted-basis-functions-to-compute-rovibrational-levels-of-an-h2o-atom-complex-in-full-dimensionality
#20
Xiao-Gang Wang, Tucker Carrington
In this paper, we present new ideas for computing rovibrational energy levels of molecules composed of two components and apply them to H2O-Cl(-). When both components are themselves molecules, Euler angles that specify their orientation with respect to an axis system attached to the inter-monomer vector are used as vibrational coordinates. For H2O-Cl(-), there is only one set of Euler angles. Using Euler angles as intermolecular vibrational coordinates is advantageous because in many cases coupling between them and coordinates that describe the shape of the monomers is unimportant...
March 14, 2017: Journal of Chemical Physics
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