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https://www.readbyqxmd.com/read/28324867/blood-glucose-levels-and-glycaemic-burden-in-76-341-patients-attending-primary-care-bittersweet-findings-from-a-9-year-cohort-study
#1
Melinda J Carrington, Neale Cohen, Joshua F Wiley
AIMS: Diabetes care is principally applied in the primary care setting whereby we examined trends in glycaemic levels and goals and estimated avoidable glycaemic burden. METHODS: We retrieved glycated haemoglobin (HbA1C) results and glucose-lowering prescription records from a patient-based medical database during 2005-2013. There were 275,480 available HbA1C measurements from 76,341 individuals managed by 960 general practitioners from 321 clinics across Australia...
February 27, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28298098/using-monomer-vibrational-wavefunctions-as-contracted-basis-functions-to-compute-rovibrational-levels-of-an-h2o-atom-complex-in-full-dimensionality
#2
Xiao-Gang Wang, Tucker Carrington
In this paper, we present new ideas for computing rovibrational energy levels of molecules composed of two components and apply them to H2O-Cl(-). When both components are themselves molecules, Euler angles that specify their orientation with respect to an axis system attached to the inter-monomer vector are used as vibrational coordinates. For H2O-Cl(-), there is only one set of Euler angles. Using Euler angles as intermolecular vibrational coordinates is advantageous because in many cases coupling between them and coordinates that describe the shape of the monomers is unimportant...
March 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28276061/implementing-a-pain-self-management-protocol-in-home-care-a-cluster-randomized-pragmatic-trial
#3
M Carrington Reid, Charles R Henderson, Melissa A Trachtenberg, Katherine L Beissner, Eileen Bach, Yolanda Barrón, Sridevi Sridharan, Christopher M Murtaugh
OBJECTIVES: To determine the effectiveness of a cognitive-behavioral pain self-management (CBPSM) protocol delivered by physical therapists (PTs) for use by older adults with activity-limiting pain receiving home care. DESIGN: A randomized pragmatic trial comparing delivery of the intervention plus usual care with usual care alone. SETTING: Community. PARTICIPANTS: Individuals aged 55 and older admitted with orders for physical therapy who endorsed activity-limiting pain and reported pain scores of 3 or greater on a scale from 0 to 10 (N = 588)...
March 9, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28254980/transcriptome-sequence-of-the-bloodstream-form-of-trypanoplasma-borreli-a-hematozoic-parasite-of-fish-transmitted-by-leeches
#4
Mark Carrington, Eva Dóró, Maria Forlenza, Geert F Wiegertjes, Steven Kelly
Here, we report a transcriptome sequence of Trypanoplasma borreli isolated from its natural host, the common carp, Cyprinus carpio The transcriptome allows an analysis of abundant cell surface proteins and acts as a comparator for understanding the evolution and pathogenicity of other Kinetoplastida, including several that infect humans.
March 2, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28235961/distributions-of-subclinical-cardiovascular-disease-in-a-socioeconomically-and-racially-diverse-sample
#5
Carrington R Wendell, Shari R Waldstein, Michele K Evans, Alan B Zonderman
BACKGROUND AND PURPOSE: Differential subgroup vulnerability to subclinical cardiovascular disease is likely, and yet few, if any, studies have addressed interactive relations of age, sex, race, and socioeconomic status (SES) to these conditions to examine nuances of known health disparities. We examined distributions of carotid atherosclerosis and arterial stiffness in a socioeconomically diverse, biracial, urban sample. METHODS: Participants (n=2270) in the population-based HANDLS study (Healthy Aging in Neighborhoods of Diversity Across the Life Span; 30-64 years old, 44% men, 57% African American, 39% with household income <125% federal poverty threshold) underwent carotid intimal medial thickness (IMT) and pulse wave velocity assessment...
February 24, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28177321/the-crystal-structure-of-pd1-a-haemophilus-surface-fibril-domain
#6
Jack Wright, Maren Thomsen, Robert Kolodziejczyk, Joshua Ridley, Jessica Sinclair, Glenn Carrington, Birendra Singh, Kristian Riesbeck, Adrian Goldman
The Haemophilus surface fibril (Hsf) is an unusually large trimeric autotransporter adhesin (TAA) expressed by the most virulent strains of H. influenzae. Hsf is known to mediate adhesion between pathogen and host, allowing the establishment of potentially deadly diseases such as epiglottitis, meningitis and pneumonia. While recent research has suggested that this TAA might adopt a novel `hairpin-like' architecture, the characterization of Hsf has been limited to in silico modelling and electron micrographs, with no high-resolution structural data available...
February 1, 2017: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/28159573/factors-associated-with-the-control-of-viral-replication-and-virologic-breakthrough-in-a-recently-infected-hiv-1-controller
#7
Victoria E Walker-Sperling, Christopher W Pohlmeyer, Rebecca T Veenhuis, Megan May, Krystle A Luna, Allison R Kirkpatrick, Oliver Laeyendecker, Andrea L Cox, Mary Carrington, Justin R Bailey, Roberto C Arduino, Joel N Blankson
HIV-1 controllers are patients who control HIV-1 viral replication without antiretroviral therapy. Control is achieved very early in the course of infection, but the mechanisms through which viral replication is restricted are not fully understood. We describe a patient who presented with acute HIV-1 infection and was found to have an HIV-1 RNA level of <100copies/mL. She did not have any known protective HLA alleles, but significant immune activation of CD8+ T cells and natural killer (NK) cells was present, and both cell types inhibited viral replication...
February 2017: EBioMedicine
https://www.readbyqxmd.com/read/28157776/translating-evidence-based-protocols-into-the-home-healthcare-setting
#8
Katherine L Beissner, Eileen Bach, Christopher M Murtaugh, MaryGrace Trifilio, Charles R Henderson, Yolanda Barrón, Melissa A Trachtenberg, Carrington Reid
Activity-limiting pain is common among older home care patients and pain management is complicated by the high prevalence of physical frailty and multimorbidity in the home care population. A comparative effectiveness study was undertaken at a large urban home care agency to examine an evidence-based pain self-management program delivered by physical therapists (PTs). This article focuses on PT training, methods implemented to reinforce content after training and to encourage uptake of the program with appropriate patients, and therapists' fidelity to the program...
February 2017: Home Healthcare Now
https://www.readbyqxmd.com/read/28153979/interspecies-comparison-of-the-mechanical-properties-and-biochemical-composition-of-byssal-threads
#9
Zeineb Bouhlel, Bertrand Genard, Neilly Ibrahim, Emily Carrington, José M F Babarro, Aynur Lok, Augusto A V Flores, Christian Pellerin, Réjean Tremblay, Isabelle Marcotte
Several bivalve species produce byssus threads to provide attachment to substrates, with mechanical properties highly variable among species. Here, we examined the distal section of byssal threads produced by a range of bivalve species (Mytilus edulis, Mytilus trossulus, Mytilus galloprovincialis, Mytilus californianus, Pinna nobilis, Perna perna, Xenostrobus securis, Brachidontes solisianus and Isognomon bicolor) collected from different nearshore environments. Morphological and mechanical properties were measured, and biochemical analyses were performed...
February 2, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28148735/sequence-and-phylogenetic-analysis-of-the-untranslated-promoter-regions-for-hla-class-i-genes
#10
Veron Ramsuran, Pedro G Hernández-Sanchez, Colm O'hUigin, Gaurav Sharma, Niamh Spence, Danillo G Augusto, Xiaojiang Gao, Christian A García-Sepúlveda, Gurvinder Kaur, Narinder K Mehra, Mary Carrington
Polymorphisms located within the MHC have been linked to many disease outcomes by mechanisms not yet fully understood in most cases. Variants located within untranslated regions of HLA genes are involved in allele-specific expression and may therefore underlie some of these disease associations. We determined sequences extending nearly 2 kb upstream of the transcription start site for 68 alleles from 57 major lineages of classical HLA class I genes. The nucleotide diversity within this promoter segment roughly follows that seen within the coding regions, with HLA-B showing the highest (∼1...
March 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28125726/a-receptor-s-tale-an-eon-in-the-life-of-a-trypanosome-receptor
#11
REVIEW
Matthew K Higgins, Harriet Lane-Serff, Paula MacGregor, Mark Carrington
African trypanosomes have complex life cycles comprising at least ten developmental forms, variously adapted to different niches in their tsetse fly vector and their mammalian hosts. Unlike many other protozoan pathogens, they are always extracellular and have evolved intricate surface coats that allow them to obtain nutrients while also protecting them from the immune defenses of either insects or mammals. The acquisition of macromolecular nutrients requires receptors that function within the context of these surface coats...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28108642/the-potential-role-for-smartphones-among-older-adults-with-chronic-noncancer-pain-a-qualitative-study
#12
Joshua E Richardson, Jennifer I Lee, Anita Nirenberg, M Carrington Reid
OBJECTIVE : To determine the role that smartphones may play in supporting older adults with chronic noncancer pain (CNCP) in order to improve pain management in this expanding population. DESIGN:  Qualitative study. SETTING:  One academically affiliated primary care practice serving older adults with CNCP in New York City. SUBJECTS : Thirteen older adults (age 65-85 years) with CNCP on chronic opioid therapy, that is, continuous use of opioids for at least six months...
January 20, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28107252/multimorbidity-and-the-risk-of-all-cause-30-day-readmission-in-the-setting-of-multidisciplinary-management-of-chronic-heart-failure-a-retrospective-analysis-of-830-hospitalized-patients-in-australia
#13
Joshua F Wiley, Yih-Kai Chan, Yasmin Ahamed, Jocasta Ball, Melinda J Carrington, Barbara Riegel, Simon Stewart
BACKGROUND: Multimorbidity has an adverse effect on health outcomes in hospitalized individuals with chronic heart failure (CHF), but the modulating effect of multidisciplinary management is unknown. OBJECTIVE: The aim of this study was to test the hypothesis that increasing morbidity would independently predict an increasing risk of 30-day readmission despite multidisciplinary management of CHF. METHODS: We studied patients hospitalized for any reason with heart failure receiving nurse-led, postdischarge multidisciplinary management...
January 20, 2017: Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28107088/the-national-eye-survey-of-trinidad-and-tobago-nestt-rationale-objectives-and-methodology
#14
Tasanee Braithwaite, Neville Q Verlander, Debra Bartholomew, Petra Bridgemohan, Kevin McNally, Allana Roach, Subash Sharma, Deo Singh, Konrad Pesudovs, Surujpal Teelucksingh, Christine Carrington, Samuel Ramsewak, Rupert Bourne
PURPOSE: This paper describes the rationale, study design and procedures of the National Eye Survey of Trinidad and Tobago (NESTT). The main objective of this survey is to obtain prevalence estimates of vision impairment and blindness for planning and policy development. METHODS: A population-based, cross-sectional survey was undertaken using random multistage cluster sampling, with probability-proportionate-to-size methods. Eligible participants aged 5 years and older were sampled from the non-institutional population in each of 120 cluster segments...
April 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28101937/methods-of-anorectal-manometry-vary-widely-in-clinical-practice-results-from-an-international-survey
#15
E V Carrington, H Heinrich, C H Knowles, S S Rao, M Fox, S M Scott
BACKGROUND: Ano-rectal manometry (ARM) is the most commonly performed investigation for assessment of anorectal dysfunction. Its use is supported by expert consensus documents and international guidelines. Variation in technology, data acquisition, and analysis affect results and clinical interpretation. This study examined variation in ARM between institutions to establish the status of current practice. METHODS: A 50-item web-based questionnaire assessing analysis and interpretation of ARM was distributed by the International Anorectal Physiology Working Group via societies representing practitioners that perform ARM...
January 18, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28097230/protection-against-plasmodium-falciparum-malaria-by-pfspz-vaccine
#16
Judith E Epstein, Kristopher M Paolino, Thomas L Richie, Martha Sedegah, Alexandra Singer, Adam J Ruben, Sumana Chakravarty, April Stafford, Richard C Ruck, Abraham G Eappen, Tao Li, Peter F Billingsley, Anita Manoj, Joana C Silva, Kara Moser, Robin Nielsen, Donna Tosh, Susan Cicatelli, Harini Ganeshan, Jessica Case, Debbie Padilla, Silas Davidson, Lindsey Garver, Elizabeth Saverino, Tooba Murshedkar, Anusha Gunasekera, Patrick S Twomey, Sharina Reyes, James E Moon, Eric R James, Natasha Kc, Minglin Li, Esteban Abot, Arnel Belmonte, Kevin Hauns, Maria Belmonte, Jun Huang, Carlos Vasquez, Shon Remich, Mary Carrington, Yonas Abebe, Amy Tillman, Bradley Hickey, Jason Regules, Eileen Villasante, B Kim Lee Sim, Stephen L Hoffman
BACKGROUND: A radiation-attenuated Plasmodium falciparum (Pf) sporozoite (SPZ) malaria vaccine, PfSPZ Vaccine, protected 6 of 6 subjects (100%) against homologous Pf (same strain as in the vaccine) controlled human malaria infection (CHMI) 3 weeks after 5 doses administered intravenously. The next step was to assess protective efficacy against heterologous Pf (different from Pf in the vaccine), after fewer doses, and at 24 weeks. METHODS: The trial assessed tolerability, safety, immunogenicity, and protective efficacy of direct venous inoculation (DVI) of 3 or 5 doses of PfSPZ Vaccine in non-immune subjects...
January 12, 2017: JCI Insight
https://www.readbyqxmd.com/read/28079376/synthesis-structures-and-co-release-capacity-of-a-family-of-water-soluble-photocorms-assessment-of-the-biocompatibility-and-their-phototoxicity-toward-human-breast-cancer-cells
#17
Indranil Chakraborty, Samantha J Carrington, Graham Roseman, Pradip K Mascharak
Two manganese(I) carbonyl complexes derived from 2-(pyridyl)benzothiazole (pbt) and 1,10-phenanthroline (phen) release carbon monoxide (CO) under low-power broad-band visible-light illumination. CO photorelease from [Mn(CO)3(pbt)(PTA)]CF3SO3 (1, where PTA = 1,3,5-triaza-7-phosphaadamantane) is accompanied by an emergence of a strong fluorescence around 400 nm from almost nonfluorescent preirradiated 1. However, [Mn(CO)3(phen)(PTA)]CF3SO3 (2) showed no such phenomenon upon prolonged illumination under similar experimental conditions...
January 12, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28077659/hiv-controllers-exhibit-enhanced-frequencies-of-major-histocompatibility-complex-class-ii-tetramer-gag-specific-cd4-t-cells-in-chronic-clade-c-hiv-1-infection
#18
Faatima Laher, Srinika Ranasinghe, Filippos Porichis, Nikoshia Mewalal, Karyn Pretorius, Nasreen Ismail, Søren Buus, Anette Stryhn, Mary Carrington, Bruce D Walker, Thumbi Ndung'u, Zaza M Ndhlovu
Immune control of viral infections is heavily dependent on helper CD4(+) T cell function. However, the understanding of the contribution of HIV-specific CD4(+) T cell responses to immune protection against HIV-1, particularly in clade C infection, remains incomplete. Recently, major histocompatibility complex (MHC) class II tetramers have emerged as a powerful tool for interrogating antigen-specific CD4(+) T cells without relying on effector functions. Here, we defined the MHC class II alleles for immunodominant Gag CD4(+) T cell epitopes in clade C virus infection, constructed MHC class II tetramers, and then used these to define the magnitude, function, and relation to the viral load of HIV-specific CD4(+) T cell responses in a cohort of untreated HIV clade C-infected persons...
April 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28034612/improving-patient-knowledge-of-palliative-care-a-randomized-controlled-intervention-study
#19
Elissa Kozlov, M Carrington Reid, Brian D Carpenter
OBJECTIVES: To determine if laypersons' knowledge about palliative care can improve with a brief education intervention. METHODS: 152 adults were recruited to participate in a web-based randomized intervention trial that followed a 2 (content)×2 (format) between-subjects design. Groups received either a video intervention, an information page intervention, a video control, or an information page control. An ANCOVA with contrast coding of two factors was utilized to assess if knowledge, as measured by the Palliative Care Knowledge Scale (PaCKS), increased post intervention...
December 21, 2016: Patient Education and Counseling
https://www.readbyqxmd.com/read/27984898/using-an-internal-coordinate-gaussian-basis-and-a-space-fixed-cartesian-coordinate-kinetic-energy-operator-to-compute-a-vibrational-spectrum-with-rectangular-collocation
#20
Sergei Manzhos, Tucker Carrington
We demonstrate that it is possible to use basis functions that depend on curvilinear internal coordinates to compute vibrational energy levels without deriving a kinetic energy operator (KEO) and without numerically computing coefficients of a KEO. This is done by using a space-fixed KEO and computing KEO matrix elements numerically. Whenever one has an excellent basis, more accurate solutions to the Schrödinger equation can be obtained by computing the KEO, potential, and overlap matrix elements numerically...
December 14, 2016: Journal of Chemical Physics
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