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https://www.readbyqxmd.com/read/27893951/events-leading-to-hospital-related-disenrollment-of-home-hospice-patients-a-study-of-primary-caregivers-perspectives
#1
Veerawat Phongtankuel, Shawn Paustian, Manney Carrington Reid, Amanda Finley, Angela Martin, John Delfs, Rosemary Baughn, Ronald D Adelman
BACKGROUND: Approximately 25% of hospice disenrollments in the United States occur as the result of hospitalization, which can lead to burdensome transitions and undesired care. Informal caregivers (e.g., spouses, children) play a critical role in caring for patients on home hospice. Research examining hospital-related disenrollment among these patients is limited. OBJECTIVE: To understand the events surrounding the hospitalization of patients discharged from home hospice through the perspective of their informal caregivers...
November 28, 2016: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27880898/hiv-1-control-by-nk-cells-via-reduced-interaction-between-kir2dl2-and-hla-c-%C3%A2-12-02-c-%C3%A2-14-03
#2
Zhansong Lin, Kimiko Kuroki, Nozomi Kuse, Xiaoming Sun, Tomohiro Akahoshi, Ying Qi, Takayuki Chikata, Takuya Naruto, Madoka Koyanagi, Hayato Murakoshi, Hiroyuki Gatanaga, Shinichi Oka, Mary Carrington, Katsumi Maenaka, Masafumi Takiguchi
Natural killer (NK) cells control viral infection in part through the interaction between killer cell immunoglobulin-like receptors (KIRs) and their human leukocyte antigen (HLA) ligands. We investigated 504 anti-retroviral (ART)-free Japanese patients chronically infected with HIV-1 and identified two KIR/HLA combinations, KIR2DL2/HLA-C(∗)12:02 and KIR2DL2/HLA-C(∗)14:03, that impact suppression of HIV-1 replication. KIR2DL2(+) NK cells suppressed viral replication in HLA-C(∗)14:03(+) or HLA-C(∗)12:02(+) cells to a significantly greater extent than did KIR2DL2(-) NK cells in vitro...
November 22, 2016: Cell Reports
https://www.readbyqxmd.com/read/27876322/teen-cuisine-impacting-dietary-habits-and-food-preparation-skills-in-adolescents
#3
Tonya T Price, Anne-Carter S Carrington, Lynn Margheim, Elena Serrano
No abstract text is available yet for this article.
November 18, 2016: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/27874992/on-the-road-to-health-equity-incorporating-culture-into-research
#4
EDITORIAL
Rosa M Gonzalez-Guarda, June Carrington
The increased mobility of people between and within countries throughout history has contributed to the diversification of populations worldwide. Despite the recent worldwide economic crisis, migration to both Northern and Southern regions in the world and from rural to urban areas has reached all-time highs (United Nations 2013). As a result, local communities have become increasingly diverse with individuals within these communities representing a myriad of races, ethnic groups, countries of origin, languages, religions, socioeconomic strata, histories, and lived experiences...
November 22, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27865116/comparison-of-contemporaneous-responses-for-eq-5d-3l-and-minnesota-living-with-heart-failure-a-case-for-disease-specific-multiattribute-utility-instrument-in-cardiovascular-conditions
#5
Sanjeewa Kularatna, Joshua Byrnes, Yih Kai Chan, Melinda J Carrington, Simon Stewart, Paul A Scuffham
BACKGROUND: The EQ-5D-3L, a generic multi-attribute utility instrument (MAUI), is widely employed to assist in economic evaluations in health care. The EQ-5D-3L lacks sensitivity when used in conditions such as cardiovascular disease (CVD). Although there are number of CVD specific quality of life instruments, currently, there are no CVD specific MAUIs. The aim of this study is to investigate the discriminative ability and responsiveness of the EQ-5D-3L and the Minnesota Living with Heart Failure Questionnaire (MLHF), a CVD specific quality of life instrument in a group of heart failure patients...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27845589/abnormalities-in-muc5ac-and-muc5b-protein-in-airway-mucus-in-asthma
#6
Marrah E Lachowicz-Scroggins, Shaopeng Yuan, Sheena C Kerr, Eleanor M Dunican, Michelle Yu, Stephen D Carrington, John V Fahy
No abstract text is available yet for this article.
November 15, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27825225/five-intermolecular-vibrations-of-the-co2-dimer-observed-via-infrared-combination-bands
#7
J Norooz Oliaee, M Dehghany, Mojtaba Rezaei, A R W McKellar, N Moazzen-Ahmadi
The weakly bound van der Waals dimer (CO2)2 has long been of considerable theoretical and experimental interest. Here, we study its low frequency intermolecular vibrations by means of combination bands in the region of the CO2 monomer ν3 fundamental (≈2350 cm(-1)), which are observed using a tunable infrared laser to probe a pulsed supersonic slit jet expansion. With the help of a recent high level ab initio calculation by Wang, Carrington, and Dawes, four intermolecular frequencies are assigned: the in-plane disrotatory bend (22...
November 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27817866/hla-c-level-is-regulated-by-a-polymorphic-oct1-binding-site-in-the-hla-c-promoter-region
#8
Nicolas Vince, Hongchuan Li, Veron Ramsuran, Vivek Naranbhai, Fuh-Mei Duh, Benjamin P Fairfax, Bahara Saleh, Julian C Knight, Stephen K Anderson, Mary Carrington
Differential HLA-C levels influence several human diseases, but the mechanisms responsible are incompletely characterized. Using a validated prediction algorithm, we imputed HLA-C cell surface levels in 228 individuals from the 1000 Genomes dataset. We tested 68,726 SNPs within the MHC for association with HLA-C level. The HLA-C promoter region variant, rs2395471, 800 bp upstream of the transcription start site, gave the most significant association with HLA-C levels (p = 4.2 × 10(-66)). This imputed expression quantitative trait locus, termed impeQTL, was also shown to associate with HLA-C expression in a genome-wide association study of 273 donors in which HLA-C mRNA expression levels were determined by quantitative PCR (qPCR) (p = 1...
October 25, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27809318/a-high-throughput-functional-genomics-workflow-based-on-crispr-cas9-mediated-targeted-mutagenesis-in-zebrafish
#9
Gaurav K Varshney, Blake Carrington, Wuhong Pei, Kevin Bishop, Zelin Chen, Chunxin Fan, Lisha Xu, Marypat Jones, Matthew C LaFave, Johan Ledin, Raman Sood, Shawn M Burgess
The zebrafish is a popular model organism for studying development and disease, and genetically modified zebrafish provide an essential tool for functional genomic studies. Numerous publications have demonstrated the efficacy of gene targeting in zebrafish using CRISPR/Cas9, and they have included descriptions of a variety of tools and methods for guide RNA synthesis and mutant identification. However, most of the published techniques are not readily scalable to increase throughput. We recently described a CRISPR/Cas9-based high-throughput mutagenesis and phenotyping pipeline in zebrafish...
December 2016: Nature Protocols
https://www.readbyqxmd.com/read/27786538/new-opioid-prescribing-guidelines-released-in-the-us-what-impact-will-they-have-in-the-care-of-older-patients-with-persistent-pain
#10
Fabio Guerriero, M Carrington Reid
To address the dramatic opioid epidemic and related-deaths from overdoses in the US, the Centers for Disease Control and Prevention (CDC) released a Guideline for Prescribing Opioids for Chronic Pain earlier this year. The guideline is designed to support clinicians caring for patients outside the context of active cancer treatment or palliative or end-of-life care. In this editorial, we review specific CDC recommendations that we believe could have positive or negative consequences when providing care to older adults with persistent pain...
October 27, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27782534/using-an-expanding-nondirect-product-harmonic-basis-with-an-iterative-eigensolver-to-compute-vibrational-energy-levels-with-as-many-as-seven-atoms
#11
James Brown, Tucker Carrington
We demonstrate that it is possible to use a variational method to compute 50 vibrational levels of ethylene oxide (a seven-atom molecule) with convergence errors less than 0.01 cm(-1). This is done by beginning with a small basis and expanding it to include product basis functions that are deemed to be important. For ethylene oxide a basis with fewer than 3 × 10(6) functions is large enough. Because the resulting basis has no exploitable structure we use a mapping to evaluate the matrix-vector products required to use an iterative eigensolver...
October 14, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27743446/monocyte-derived-dendritic-cells-impair-early-graft-function-following-allogeneic-islet-transplantation
#12
Kevin V Chow, Emma M Carrington, Yifan Zhan, Andrew M Lew, Robyn M Sutherland
Islet transplantation can cure type 1 diabetes, but is limited by lack of donor organs and early graft dysfunction, such that many patients require multiple transplants to achieve insulin independence. Monocyte derived dendritic cells (moDCs) arise during inflammation and allograft encounters where they can promote various innate and adaptive immune responses. To determine whether moDCs impair early graft function following allogeneic islet transplantation, we transplanted MHC-mismatched BALB/c (H-2d) islets into diabetic C57BL/6-CCR2...
October 13, 2016: Cell Transplantation
https://www.readbyqxmd.com/read/27741972/preface
#13
M Carrington Reid
No abstract text is available yet for this article.
November 2016: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/27741971/expanding-targets-for-intervention-in-later-life-pain-what-role-can-patient-beliefs-expectations-and-pleasant-activities-play
#14
REVIEW
M Carrington Reid
Clinicians are often challenged to find targets for intervention in older adults with chronic pain. This article highlights 3 targets clinicians should consider when formulating their multimodal treatment plans to include older patients' attitudes and beliefs about pain and pain treatments, expectations regarding treatment outcomes, and pleasurable activity pursuits.
November 2016: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/27727238/long-term-high-frequency-in-situ-measurements-of-intertidal-mussel-bed-temperatures-using-biomimetic-sensors
#15
Brian Helmuth, Francis Choi, Allison Matzelle, Jessica L Torossian, Scott L Morello, K A S Mislan, Lauren Yamane, Denise Strickland, P Lauren Szathmary, Sarah E Gilman, Alyson Tockstein, Thomas J Hilbish, Michael T Burrows, Anne Marie Power, Elizabeth Gosling, Nova Mieszkowska, Christopher D G Harley, Michael Nishizaki, Emily Carrington, Bruce Menge, Laura Petes, Melissa M Foley, Angela Johnson, Megan Poole, Mae M Noble, Erin L Richmond, Matt Robart, Jonathan Robinson, Jerod Sapp, Jackie Sones, Bernardo R Broitman, Mark W Denny, Katharine J Mach, Luke P Miller, Michael O'Donnell, Philip Ross, Gretchen E Hofmann, Mackenzie Zippay, Carol Blanchette, J A Macfarlan, Eugenio Carpizo-Ituarte, Benjamin Ruttenberg, Carlos E Peña Mejía, Christopher D McQuaid, Justin Lathlean, Cristián J Monaco, Katy R Nicastro, Gerardo Zardi
At a proximal level, the physiological impacts of global climate change on ectothermic organisms are manifest as changes in body temperatures. Especially for plants and animals exposed to direct solar radiation, body temperatures can be substantially different from air temperatures. We deployed biomimetic sensors that approximate the thermal characteristics of intertidal mussels at 71 sites worldwide, from 1998-present. Loggers recorded temperatures at 10-30 min intervals nearly continuously at multiple intertidal elevations...
October 11, 2016: Scientific Data
https://www.readbyqxmd.com/read/27693919/differential-response-of-cassava-genotypes-to-infection-by-cassava-mosaic-geminiviruses
#16
Paul Kuria, Muhammad Ilyas, Elijah Ateka, Douglas Miano, Justus Onguso, James C Carrington, Nigel J Taylor
Mitigation of cassava mosaic disease (CMD) focuses on the introgression of resistance imparted by the polygenic recessive (CMD1), dominant monogenic (CMD2) and CMD3 loci. The mechanism(s) of resistance they impart, however, remain unknown. Two CMD susceptible and nine CMD resistant cassava genotypes were inoculated by microparticle bombardment with infectious clones of African cassava mosaic virus Cameroon strain (ACMV-CM) and the Kenyan strain K201 of East African cassava mosaic virus (EACMV KE2 [K201]). Genotypes carrying the CMD1 (TMS 30572), CMD2 (TME 3, TME 204 and Oko-iyawo) and CMD3 (TMS 97/0505) resistance mechanisms showed high levels of resistance to ACMV-CM, with viral DNA undetectable by PCR beyond 7days post inoculation (dpi)...
January 2, 2017: Virus Research
https://www.readbyqxmd.com/read/27665490/killer-cell-immunoglobulin-like-receptors-are-associated-with-common-variable-immune-deficiency-pathogenesis
#17
Yuge Wang, Tracy Hwangpo, Maureen P Martin, Nicolas Vince, Ying Qi, Richard J Reynolds, Devin Absher, Xiaojiang Gao, Carol A Ballinger, Peter D Burrows, T Prescott Atkinson, Elizabeth E Brown, Ada Elgavish, Cunren Liu, Mary Carrington, Harry W Schroeder
No abstract text is available yet for this article.
November 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27630194/inevitability-and-containment-of-replication-errors-for-eukaryotic-genome-lengths-spanning-megabase-to-gigabase
#18
Mohammed Al Mamun, Luca Albergante, Alberto Moreno, James T Carrington, J Julian Blow, Timothy J Newman
The replication of DNA is initiated at particular sites on the genome called replication origins (ROs). Understanding the constraints that regulate the distribution of ROs across different organisms is fundamental for quantifying the degree of replication errors and their downstream consequences. Using a simple probabilistic model, we generate a set of predictions on the extreme sensitivity of error rates to the distribution of ROs, and how this distribution must therefore be tuned for genomes of vastly different sizes...
September 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27560714/mcl-1-is-required-throughout-b-cell-development-and-its-loss-sensitizes-specific-b-cell-subsets-to-inhibition-of-bcl-2-or-bcl-xl
#19
Ingela B Vikström, Anne Slomp, Emma M Carrington, Laura M Moesbergen, Catherine Chang, Gemma L Kelly, Stefan P Glaser, J H Marco Jansen, Jeanette H W Leusen, Andreas Strasser, David C S Huang, Andrew M Lew, Victor Peperzak, David M Tarlinton
Pro-survival BCL-2 family members protect cells from programmed cell death that can be induced by multiple internal or external cues. Within the haematopoietic lineages, the BCL-2 family members BCL-2, BCL-XL and MCL-1 are known to support cell survival but the individual and overlapping roles of these pro-survival BCL-2 proteins for the persistence of individual leukocyte subsets in vivo has not yet been determined. By combining inducible knockout mouse models with the BH3-mimetic compound ABT-737, which inhibits BCL-2, BCL-XL and BCL-W, we found that dependency on MCL-1, BCL-XL or BCL-2 expression changes during B-cell development...
August 25, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27556007/addressing-ethical-challenges-in-the-genetics-substudy-of-the-national-eye-survey-of-trinidad-and-tobago-gsnestt
#20
Allana N Roach, Tasanee Braithwaite, Christine Carrington, Elysse Marcellin, Subash Sharma, Aroon Hingorani, Juan P Casas, Michael A Hauser, R Rand Allingham, Samuel S Ramsewak, Rupert Bourne
BACKGROUND: The conduct of international collaborative genomics research raises distinct ethical challenges that require special consideration, especially if conducted in settings that are research-naïve or resource-limited. Although there is considerable literature on these issues, there is a dearth of literature chronicling approaches taken to address these issues in the field. Additionally no previous ethical guidelines have been developed to support similar research in Trinidad and Tobago...
June 2016: Applied & Translational Genomics
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