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https://www.readbyqxmd.com/read/28449009/the-prognostic-value-of-dynamic-contrast-enhanced-mri-contrast-agent-transfer-constant-k-trans-in-cervical-cancer-is-explained-by-plasma-flow-rather-than-vessel-permeability
#1
Ben R Dickie, Chris J Rose, Lucy E Kershaw, Stephanie B Withey, Bernadette M Carrington, Susan E Davidson, Gillian Hutchison, Catharine M L West
BACKGROUND: The microvascular contrast agent transfer constant K(trans) has shown prognostic value in cervical cancer patients treated with chemoradiotherapy. This study aims to determine whether this is explained by the contribution to K(trans) of plasma flow (Fp), vessel permeability surface-area product (PS), or a combination of both. METHODS: Pre-treatment dynamic contrast-enhanced MRI (DCE-MRI) data from 36 patients were analysed using the two-compartment exchange model...
April 27, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28442184/pigmented-villonodular-synovitis-of-the-knee-a-retrospective-analysis-of-214-cases-at-a-uk-tertiary-referral-centre
#2
K H Patel, P D Gikas, R C Pollock, R W Carrington, S R Cannon, J A Skinner, T W Briggs, W J S Aston
AIMS: Pigmented villonodular synovitis (PVNS) is a rare, locally aggressive and potentially recurrent synovial disease. We present the largest single-centre experience of knee PVNS. Our aim was to evaluate our tertiary hospital's experience in the management of knee PVNS. PATIENTS AND METHODS: Retrospective data collection of consecutive cases of knee PVNS from 2002 to 2015. RESULTS: In total, 214 cases of knee PVNS were identified which represented 53...
April 22, 2017: Knee
https://www.readbyqxmd.com/read/28429320/euglena-gracilis-genome-and-transcriptome-organelles-nuclear-genome-assembly-strategies-and-initial-features
#3
ThankGod Echezona Ebenezer, Mark Carrington, Michael Lebert, Steven Kelly, Mark C Field
Euglena gracilis is a major component of the aquatic ecosystem and together with closely related species, is ubiquitous worldwide. Euglenoids are an important group of protists, possessing a secondarily acquired plastid and are relatives to the Kinetoplastidae, which themselves have global impact as disease agents. To understand the biology of E. gracilis, as well as to provide further insight into the evolution and origins of the Kinetoplastidae, we embarked on sequencing the nuclear genome; the plastid and mitochondrial genomes are already in the public domain...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28401883/cognate-antigen-engagement-on-parenchymal-cells-stimulates-cd8-t-cell-proliferation-in-situ
#4
Robyn M Sutherland, Sarah L Londrigan, Jamie L Brady, Emma M Carrington, Julia M Marchingo, Susanne Heinzel, Philip D Hodgkin, Kate L Graham, Thomas W Kay, Yifan Zhan, Andrew M Lew
T-cell responses are initiated upon cognate presentation by professional antigen presenting cells in lymphoid tissue. T cells then migrate to inflamed tissues, but further T-cell stimulation in these parenchymal target sites is not well understood. Here we show that T-cell expansion within inflamed tissues is a distinct phase that is neither a classical primary nor classical secondary response. This response, which we term 'the mezzanine response', commences within days after initial antigen encounter, unlike the secondary response that usually occurs weeks after priming...
April 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/28388099/perspective-computing-ro-vibrational-spectra-of-molecules-with-more-than-four-atoms
#5
Tucker Carrington
In this perspective, I review methods for computing (ro-)vibrational energy levels and wavefunctions of molecules with more than four atoms. I identify three problems one confronts (1) reducing the size of the basis; (2) computing hundreds of eigenvalues and eigenvectors of a large matrix; (3) calculating matrix elements of the potential, and present ideas that mitigate them. Most modern methods use a combination of these ideas. I divide popular methods into groups based on the strategies used to deal with the three problems...
March 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28381627/characterization-of-rbp9-and-rbp10-two-developmentally-regulated-rna-binding-proteins-in-trypanosoma-brucei
#6
Luis Miguel De Pablos, Steve Kelly, Janaina de Freitas Nascimento, Jack Sunter, Mark Carrington
The fate of an mRNA is determined by its interaction with proteins and small RNAs within dynamic complexes called ribonucleoprotein complexes (mRNPs). In Trypanosoma brucei and related kinetoplastids, responses to internal and external signals are mainly mediated by post-transcriptional processes. Here, we used proximity-dependent biotin identification (BioID) combined with RNA-seq to investigate the changes resulting from ectopic expression of RBP10 and RBP9, two developmentally regulated RNA-binding proteins (RBPs)...
April 2017: Open Biology
https://www.readbyqxmd.com/read/28378721/synthesis-and-structures-of-photoactive-manganese-carbonyl-complexes-derived-from-2-pyridin-2-yl-1-3-benzothiazole-and-2-quinolin-2-yl-1-3-benzothiazole
#7
Jenny Stenger-Smith, Indranil Chakraborty, Samantha Carrington, Pradip Mascharak
PhotoCORMs (photo-active CO-releasing molecules) have emerged as a class of CO donors where the CO release process can be triggered upon illumination with light of appropriate wavelength. We have recently reported an Mn-based photoCORM, namely [MnBr(pbt)(CO)3] [pbt is 2-(pyridin-2-yl)-1,3-benzothiazole], where the CO release event can be tracked within cellular milieu by virtue of the emergence of strong blue fluorescence. In pursuit of developing more such trackable photoCORMs, we report herein the syntheses and structural characterization of two Mn(I)-carbonyl complexes, namely fac-tricarbonylchlorido[2-(pyridin-2-yl)-1,3-benzothiazole-κ(2)N,N']manganese(I), [MnCl(C12H8N2S)(CO)3], (1), and fac-tricarbonylchlorido[2-(quinolin-2-yl)-1,3-benzothiazole-κ(2)N,N']manganese(I), [MnCl(C16H10N2S)(CO)3], (2)...
April 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/28371406/in-vitro-generation-of-polysialylated-cervical-mucins-by-bacterial-polysialyltransferases-to-counteract-cytotoxicity-of-extracellular-histones
#8
Sebastian P Galuska, Christina E Galuska, Tharmala Tharmalingam, Kristina Zlatina, Gerlinde Prem, Farzali C O Husejnov, Pauline M Rudd, Willie F Vann, Colm Reid, Justine Vionnet, Mary E Gallagher, Faye A Carrington, Sarah-Louise Hassett, Stephen D Carrington
Neutrophil extracellular traps (NET) are formed against pathogens. However, various diseases are directly linked to this meshwork of DNA. The cytotoxic properties of extracellular histones especially seem to be an important trigger during these diseases. Furthermore, NET accumulation on implants is discussed to result in an impaired efficiency or failure, depending on the category of implant. Interestingly, mucins have been investigated as surface coatings potentially capable of reducing neutrophil adhesion...
March 31, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28363776/facilitating-trypanosome-imaging
#9
Marius Glogger, Ines Subota, Anna Pezzarossa, Anna-Lena Denecke, Mark Carrington, Susanne F Fenz, Markus Engstler
Research on trypanosomes as a model organism has provided a substantial contribution to a detailed understanding of basic cellular processes within the last few years. At the same time, major advances in super-resolution microscopy have been achieved, facilitating the resolution of biological structures in living cells at a scale of a few nm. However, the motility of trypanosomes has prevented access to high resolution microscopy of live cells. Here, we present a hydrogel based on poly(ethylene glycol) functionalized with either norbornene or thiol moieties for UV induced thiol-ene crosslinking for the embedding and imaging of live trypanosomes...
March 28, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28362427/anti-apoptotic-proteins-bcl-2-mcl-1-and-a1-summate-collectively-to-maintain-survival-of-immune-cell-populations-both-in-vitro-and-in-vivo
#10
Emma M Carrington, Yifan Zhan, Jamie L Brady, Jian-Guo Zhang, Robyn M Sutherland, Natasha S Anstee, Robyn L Schenk, Ingela B Vikstrom, Rebecca B Delconte, David Segal, Nicholas D Huntington, Philippe Bouillet, David M Tarlinton, David Cs Huang, Andreas Strasser, Suzanne Cory, Marco J Herold, Andrew M Lew
Survival of various immune cell populations has been proposed to preferentially rely on a particular anti-apoptotic BCL-2 family member, for example, naive T cells require BCL-2, while regulatory T cells require MCL-1. Here we examined the survival requirements of multiple immune cell subsets in vitro and in vivo, using both genetic and pharmacological approaches. Our findings support a model in which survival is determined by quantitative participation of multiple anti-apoptotic proteins rather than by a single anti-apoptotic protein...
March 31, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28339327/raising-public-awareness-of-clinical-trials-development-of-messages-for-a-national-health-communication-campaign
#11
Holly A Massett, David M Dilts, Robert Bailey, Jennifer Berktold, Rebecca Ledsky, Nancy L Atkinson, Grace Mishkin, Andrea Denicoff, Rose Mary Padberg, Marin P Allen, Karen Silver, Kelli Carrington, Lenora E Johnson
Clinical trials are essential for developing new and effective treatments and improving patient quality of life; however, many trials cannot answer their primary research questions because they fall short of their recruitment goals. This article reports the results of formative research conducted in two populations, the public and primary care physicians, to identify messages that may raise awareness and increase interest in clinical trials and be used in a national communication campaign. Results suggested that participants were primarily motivated to participate in clinical trials out of a self-interest to help themselves first...
May 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28324867/blood-glucose-levels-and-glycaemic-burden-in-76-341-patients-attending-primary-care-bittersweet-findings-from-a-9-year-cohort-study
#12
Melinda J Carrington, Neale Cohen, Joshua F Wiley
AIMS: Diabetes care is principally applied in the primary care setting whereby we examined trends in glycaemic levels and goals and estimated avoidable glycaemic burden. METHODS: We retrieved glycated haemoglobin (HbA1C) results and glucose-lowering prescription records from a patient-based medical database during 2005-2013. There were 275,480 available HbA1C measurements from 76,341 individuals managed by 960 general practitioners from 321 clinics across Australia...
February 27, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28298098/using-monomer-vibrational-wavefunctions-as-contracted-basis-functions-to-compute-rovibrational-levels-of-an-h2o-atom-complex-in-full-dimensionality
#13
Xiao-Gang Wang, Tucker Carrington
In this paper, we present new ideas for computing rovibrational energy levels of molecules composed of two components and apply them to H2O-Cl(-). When both components are themselves molecules, Euler angles that specify their orientation with respect to an axis system attached to the inter-monomer vector are used as vibrational coordinates. For H2O-Cl(-), there is only one set of Euler angles. Using Euler angles as intermolecular vibrational coordinates is advantageous because in many cases coupling between them and coordinates that describe the shape of the monomers is unimportant...
March 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28276061/implementing-a-pain-self-management-protocol-in-home-care-a-cluster-randomized-pragmatic-trial
#14
M Carrington Reid, Charles R Henderson, Melissa A Trachtenberg, Katherine L Beissner, Eileen Bach, Yolanda Barrón, Sridevi Sridharan, Christopher M Murtaugh
OBJECTIVES: To determine the effectiveness of a cognitive-behavioral pain self-management (CBPSM) protocol delivered by physical therapists (PTs) for use by older adults with activity-limiting pain receiving home care. DESIGN: A randomized pragmatic trial comparing delivery of the intervention plus usual care with usual care alone. SETTING: Community. PARTICIPANTS: Individuals aged 55 and older admitted with orders for physical therapy who endorsed activity-limiting pain and reported pain scores of 3 or greater on a scale from 0 to 10 (N = 588)...
March 9, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28254980/transcriptome-sequence-of-the-bloodstream-form-of-trypanoplasma-borreli-a-hematozoic-parasite-of-fish-transmitted-by-leeches
#15
Mark Carrington, Eva Dóró, Maria Forlenza, Geert F Wiegertjes, Steven Kelly
Here, we report a transcriptome sequence of Trypanoplasma borreli isolated from its natural host, the common carp, Cyprinus carpio The transcriptome allows an analysis of abundant cell surface proteins and acts as a comparator for understanding the evolution and pathogenicity of other Kinetoplastida, including several that infect humans.
March 2, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28235961/distributions-of-subclinical-cardiovascular-disease-in-a-socioeconomically-and-racially-diverse-sample
#16
Carrington R Wendell, Shari R Waldstein, Michele K Evans, Alan B Zonderman
BACKGROUND AND PURPOSE: Differential subgroup vulnerability to subclinical cardiovascular disease is likely, and yet few, if any, studies have addressed interactive relations of age, sex, race, and socioeconomic status (SES) to these conditions to examine nuances of known health disparities. We examined distributions of carotid atherosclerosis and arterial stiffness in a socioeconomically diverse, biracial, urban sample. METHODS: Participants (n=2270) in the population-based HANDLS study (Healthy Aging in Neighborhoods of Diversity Across the Life Span; 30-64 years old, 44% men, 57% African American, 39% with household income <125% federal poverty threshold) underwent carotid intimal medial thickness (IMT) and pulse wave velocity assessment...
April 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28177321/the-crystal-structure-of-pd1-a-haemophilus-surface-fibril-domain
#17
Jack Wright, Maren Thomsen, Robert Kolodziejczyk, Joshua Ridley, Jessica Sinclair, Glenn Carrington, Birendra Singh, Kristian Riesbeck, Adrian Goldman
The Haemophilus surface fibril (Hsf) is an unusually large trimeric autotransporter adhesin (TAA) expressed by the most virulent strains of H. influenzae. Hsf is known to mediate adhesion between pathogen and host, allowing the establishment of potentially deadly diseases such as epiglottitis, meningitis and pneumonia. While recent research has suggested that this TAA might adopt a novel `hairpin-like' architecture, the characterization of Hsf has been limited to in silico modelling and electron micrographs, with no high-resolution structural data available...
February 1, 2017: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/28159573/factors-associated-with-the-control-of-viral-replication-and-virologic-breakthrough-in-a-recently-infected-hiv-1-controller
#18
Victoria E Walker-Sperling, Christopher W Pohlmeyer, Rebecca T Veenhuis, Megan May, Krystle A Luna, Allison R Kirkpatrick, Oliver Laeyendecker, Andrea L Cox, Mary Carrington, Justin R Bailey, Roberto C Arduino, Joel N Blankson
HIV-1 controllers are patients who control HIV-1 viral replication without antiretroviral therapy. Control is achieved very early in the course of infection, but the mechanisms through which viral replication is restricted are not fully understood. We describe a patient who presented with acute HIV-1 infection and was found to have an HIV-1 RNA level of <100copies/mL. She did not have any known protective HLA alleles, but significant immune activation of CD8+ T cells and natural killer (NK) cells was present, and both cell types inhibited viral replication...
February 2017: EBioMedicine
https://www.readbyqxmd.com/read/28157776/translating-evidence-based-protocols-into-the-home-healthcare-setting
#19
Katherine L Beissner, Eileen Bach, Christopher M Murtaugh, MaryGrace Trifilio, Charles R Henderson, Yolanda Barrón, Melissa A Trachtenberg, Carrington Reid
Activity-limiting pain is common among older home care patients and pain management is complicated by the high prevalence of physical frailty and multimorbidity in the home care population. A comparative effectiveness study was undertaken at a large urban home care agency to examine an evidence-based pain self-management program delivered by physical therapists (PTs). This article focuses on PT training, methods implemented to reinforce content after training and to encourage uptake of the program with appropriate patients, and therapists' fidelity to the program...
February 2017: Home Healthcare Now
https://www.readbyqxmd.com/read/28153979/interspecies-comparison-of-the-mechanical-properties-and-biochemical-composition-of-byssal-threads
#20
Zeineb Bouhlel, Bertrand Genard, Neilly Ibrahim, Emily Carrington, José M F Babarro, Aynur Lok, Augusto A V Flores, Christian Pellerin, Réjean Tremblay, Isabelle Marcotte
Several bivalve species produce byssus threads to provide attachment to substrates, with mechanical properties highly variable among species. Here, we examined the distal section of byssal threads produced by a range of bivalve species (Mytilus edulis, Mytilus trossulus, Mytilus galloprovincialis, Mytilus californianus, Pinna nobilis, Perna perna, Xenostrobus securis, Brachidontes solisianus and Isognomon bicolor) collected from different nearshore environments. Morphological and mechanical properties were measured, and biochemical analyses were performed...
February 2, 2017: Journal of Experimental Biology
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