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Kevin V Chow, Emma M Carrington, Yifan Zhan, Andrew M Lew, Robyn M Sutherland
Islet transplantation can cure type 1 diabetes, but is limited by lack of donor organs and early graft dysfunction, such that many patients require multiple transplants to achieve insulin independence. Monocyte derived dendritic cells (moDCs) arise during inflammation and allograft encounters where they can promote various innate and adaptive immune responses. To determine whether moDCs impair early graft function following allogeneic islet transplantation, we transplanted MHC-mismatched BALB/c (H-2d) islets into diabetic C57BL/6-CCR2...
October 13, 2016: Cell Transplantation
M Carrington Reid
No abstract text is available yet for this article.
November 2016: Clinics in Geriatric Medicine
M Carrington Reid
Clinicians are often challenged to find targets for intervention in older adults with chronic pain. This article highlights 3 targets clinicians should consider when formulating their multimodal treatment plans to include older patients' attitudes and beliefs about pain and pain treatments, expectations regarding treatment outcomes, and pleasurable activity pursuits.
November 2016: Clinics in Geriatric Medicine
Brian Helmuth, Francis Choi, Allison Matzelle, Jessica L Torossian, Scott L Morello, K A S Mislan, Lauren Yamane, Denise Strickland, P Lauren Szathmary, Sarah E Gilman, Alyson Tockstein, Thomas J Hilbish, Michael T Burrows, Anne Marie Power, Elizabeth Gosling, Nova Mieszkowska, Christopher D G Harley, Michael Nishizaki, Emily Carrington, Bruce Menge, Laura Petes, Melissa M Foley, Angela Johnson, Megan Poole, Mae M Noble, Erin L Richmond, Matt Robart, Jonathan Robinson, Jerod Sapp, Jackie Sones, Bernardo R Broitman, Mark W Denny, Katharine J Mach, Luke P Miller, Michael O'Donnell, Philip Ross, Gretchen E Hofmann, Mackenzie Zippay, Carol Blanchette, J A Macfarlan, Eugenio Carpizo-Ituarte, Benjamin Ruttenberg, Carlos E Peña Mejía, Christopher D McQuaid, Justin Lathlean, Cristián J Monaco, Katy R Nicastro, Gerardo Zardi
At a proximal level, the physiological impacts of global climate change on ectothermic organisms are manifest as changes in body temperatures. Especially for plants and animals exposed to direct solar radiation, body temperatures can be substantially different from air temperatures. We deployed biomimetic sensors that approximate the thermal characteristics of intertidal mussels at 71 sites worldwide, from 1998-present. Loggers recorded temperatures at 10-30 min intervals nearly continuously at multiple intertidal elevations...
October 11, 2016: Scientific Data
Paul Kuria, Muhammad Ilyas, Elijah Ateka, Douglas Miano, Justus Onguso, James C Carrington, Nigel J Taylor
Mitigation of cassava mosaic disease (CMD) focuses on the introgression of resistance imparted by the polygenic recessive (CMD1), dominant monogenic (CMD2) and CMD3 loci. The mechanism(s) of resistance they impart, however, remain unknown. Two CMD susceptible and nine CMD resistant cassava genotypes were inoculated by microparticle bombardment with infectious clones of African cassava mosaic virus Cameroon strain (ACMV-CM) and the Kenyan strain K201 of East African cassava mosaic virus (EACMV KE2 [K201]). Genotypes carrying the CMD1 (TMS 30572), CMD2 (TME 3, TME 204 and Oko-iyawo) and CMD3 (TMS 97/0505) resistance mechanisms showed high levels of resistance to ACMV-CM, with viral DNA undetectable by PCR beyond 7days post inoculation (dpi)...
September 29, 2016: Virus Research
Yuge Wang, Tracy Hwangpo, Maureen P Martin, Nicolas Vince, Ying Qi, Richard J Reynolds, Devin Absher, Xiaojiang Gao, Carol A Ballinger, Peter D Burrows, T Prescott Atkinson, Elizabeth E Brown, Ada Elgavish, Cunren Liu, Mary Carrington, Harry W Schroeder
No abstract text is available yet for this article.
September 21, 2016: Journal of Allergy and Clinical Immunology
Mohammed Al Mamun, Luca Albergante, Alberto Moreno, James T Carrington, J Julian Blow, Timothy J Newman
The replication of DNA is initiated at particular sites on the genome called replication origins (ROs). Understanding the constraints that regulate the distribution of ROs across different organisms is fundamental for quantifying the degree of replication errors and their downstream consequences. Using a simple probabilistic model, we generate a set of predictions on the extreme sensitivity of error rates to the distribution of ROs, and how this distribution must therefore be tuned for genomes of vastly different sizes...
September 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
Ingela B Vikström, Anne Slomp, Emma M Carrington, Laura M Moesbergen, Catherine Chang, Gemma L Kelly, Stefan P Glaser, J H Marco Jansen, Jeanette H W Leusen, Andreas Strasser, David C S Huang, Andrew M Lew, Victor Peperzak, David M Tarlinton
Pro-survival BCL-2 family members protect cells from programmed cell death that can be induced by multiple internal or external cues. Within the haematopoietic lineages, the BCL-2 family members BCL-2, BCL-XL and MCL-1 are known to support cell survival but the individual and overlapping roles of these pro-survival BCL-2 proteins for the persistence of individual leukocyte subsets in vivo has not yet been determined. By combining inducible knockout mouse models with the BH3-mimetic compound ABT-737, which inhibits BCL-2, BCL-XL and BCL-W, we found that dependency on MCL-1, BCL-XL or BCL-2 expression changes during B-cell development...
2016: Cell Death & Disease
Allana N Roach, Tasanee Braithwaite, Christine Carrington, Elysse Marcellin, Subash Sharma, Aroon Hingorani, Juan P Casas, Michael A Hauser, R Rand Allingham, Samuel S Ramsewak, Rupert Bourne
BACKGROUND: The conduct of international collaborative genomics research raises distinct ethical challenges that require special consideration, especially if conducted in settings that are research-naïve or resource-limited. Although there is considerable literature on these issues, there is a dearth of literature chronicling approaches taken to address these issues in the field. Additionally no previous ethical guidelines have been developed to support similar research in Trinidad and Tobago...
June 2016: Applied & Translational Genomics
Sheila M Gephart, Alycia A Bristol, Judy L Dye, Brooke A Finley, Jane M Carrington
Unintended consequences of electronic health records represent undesired effects on individuals or systems, which may contradict initial goals and impact patient care. The purpose of this study was to determine the extent to which a new quantitative measure called the Carrington-Gephart Unintended Consequences of Electronic Health Record Questionnaire (CG-UCE-Q) was valid and reliable. Then, it was used to describe acute care nurses' experience with unintended consequences of electronic health records and relate them to the professional practice environment...
October 2016: Computers, Informatics, Nursing: CIN
Emma Davé, Ralph Adams, Oliver Zaccheo, Bruce Carrington, Joanne E Compson, Sarah Dugdale, Michael Airey, Sarah Malcolm, Hanna Hailu, Gavin Wild, Alison Turner, James Heads, Kaushik Sarkar, Andrew Ventom, Diane Marshall, Mark Jairaj, Tim Kopotsha, Louis Christodoulou, Miren Zamacona, Alastair D Lawson, Sam Heywood, David P Humphreys
An antibody format, termed Fab-dsFv, has been designed for clinical indications that require monovalent target binding in the absence of direct Fc receptor (FcR) binding while retaining substantial serum presence. The variable fragment (Fv) domain of a humanized albumin-binding antibody was fused to the C-termini of Fab constant domains, such that the VL and VH domains were individually connected to the Cκ and CH1 domains by peptide linkers, respectively. The anti-albumin Fv was selected for properties thought to be desirable to ensure a durable serum half-life mediated via FcRn...
August 17, 2016: MAbs
Magdalena Sips, Qingquan Liu, Monia Draghi, Musie Ghebremichael, Christoph T Berger, Todd J Suscovich, Yongtao Sun, Bruce D Walker, Mary Carrington, Marcus Altfeld, Peter Brouckaert, Philip L De Jager, Galit Alter
Differences in HLA-C expression are inversely correlated with HIV viral load set-point and slower progression to AIDS, linked to enhanced cytotoxic T cell immunity. Yet, beyond T cells, HLA-C serves as a dominant ligand for Natural Killer (NK) cell Killer Immunoglobulin-like Receptors (KIR). Thus, we speculated that HLA-C expression levels may also impact NK activity, thereby modulating HIV antiviral control. Phenotypic and functional profiling was performed on freshly isolated PBMCs. HLA-C expression was linked to changes in NK subset distribution and licensing, particularly in HLA-C1/C1, KIR2DL3+2DL2- individuals...
August 10, 2016: Human Immunology
Christopher M Murtaugh, Katherine L Beissner, Yolanda Barrón, Melissa A Trachtenberg, Eileen Bach, Charles R Henderson, Sridevi Sridharan, M Carrington Reid
OBJECTIVES: To describe racial/ethnic group differences in pain presentation and the prevalence of psychosocial factors among patients admitted to home health care, and to determine the extent of racial/ethnic group differences in the association of psychosocial factors with pain intensity and pain-related disability. METHODS: We analyzed cross-sectional data on 588 patients with activity-limiting pain admitted to home care for physical therapy. Three psychosocial factors were assessed: depressive symptoms, pain self-efficacy, and health literacy...
August 11, 2016: Clinical Journal of Pain
Alberto Moreno, Jamie T Carrington, Luca Albergante, Mohammed Al Mamun, Emma J Haagensen, Eirini-Stavroula Komseli, Vassilis G Gorgoulis, Timothy J Newman, J Julian Blow
To prevent rereplication of genomic segments, the eukaryotic cell cycle is divided into two nonoverlapping phases. During late mitosis and G1 replication origins are "licensed" by loading MCM2-7 double hexamers and during S phase licensed replication origins activate to initiate bidirectional replication forks. Replication forks can stall irreversibly, and if two converging forks stall with no intervening licensed origin-a "double fork stall" (DFS)-replication cannot be completed by conventional means. We previously showed how the distribution of replication origins in yeasts promotes complete genome replication even in the presence of irreversible fork stalling...
September 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
Una E Makris, Robin T Higashi, Emily G Marks, Liana Fraenkel, Thomas M Gill, Janna L Friedly, M Carrington Reid
OBJECTIVE: Back pain is the most common type of pain reported by older adults, yet current management strategies often do not address the multi-dimensional impacts on older adults who face unique challenges as compared with younger populations. The objective of this qualitative study was to assess the physical, psychological, and social impacts of back pain (severe enough to restrict activity, hereafter referred to as restricting back pain) on older adults. DESIGN: This was a qualitative study using semi-structured interviews and focus groups...
August 11, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Javier Martinez-Picado, Paul J McLaren, Itziar Erkizia, Maureen P Martin, Susana Benet, Margalida Rotger, Judith Dalmau, Dan Ouchi, Steven M Wolinsky, Sudhir Penugonda, Huldrych F Günthard, Jacques Fellay, Mary Carrington, Nuria Izquierdo-Useros, Amalio Telenti
Siglec-1/CD169 is a myeloid-cell surface receptor critical for HIV-1 capture and infection of bystander target cells. To dissect the role of SIGLEC1 in natura, we scan a large population genetic database and identify a loss-of-function variant (Glu88Ter) that is found in ∼1% of healthy people. Exome analysis and direct genotyping of 4,233 HIV-1-infected individuals reveals two Glu88Ter homozygous and 97 heterozygous subjects, allowing the analysis of ex vivo and in vivo consequences of SIGLEC1 loss-of-function...
2016: Nature Communications
Lauren R Meltzer, Cathy D Meade, Diana B Diaz, Monica S Carrington, Thomas H Brandon, Paul B Jacobsen, Judith C McCaffrey, Eric B Haura, Vani N Simmons
We describe the series of iterative steps used to develop a smoking relapse-prevention intervention customized to the needs of cancer patients. Informed by relevant literature and a series of preliminary studies, an educational tool (DVD) was developed to target the unique smoking relapse risk factors among cancer patients. Learner verification interviews were conducted with 10 cancer patients who recently quit smoking to elicit feedback and inform the development of the DVD. The DVD was then refined using iterative processes and feedback from the learner verification interviews...
August 1, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
Robert Wodraszka, Tucker Carrington
In this paper, we propose a pruned, nondirect product multi-configuration time dependent Hartree (MCTDH) method for solving the Schrödinger equation. MCTDH uses optimized 1D basis functions, called single particle functions, but the size of the standard direct product MCTDH basis scales exponentially with D, the number of coordinates. We compare the pruned approach to standard MCTDH calculations for basis sizes small enough that the latter are possible and demonstrate that pruning the basis reduces the CPU cost of computing vibrational energy levels of acetonitrile (D = 12) by more than two orders of magnitude...
July 28, 2016: Journal of Chemical Physics
Wilfredo F Garcia-Beltran, Angelique Hölzemer, Gloria Martrus, Amy W Chung, Yovana Pacheco, Camille R Simoneau, Marijana Rucevic, Pedro A Lamothe-Molina, Thomas Pertel, Tae-Eun Kim, Haley Dugan, Galit Alter, Julie Dechanet-Merville, Stephanie Jost, Mary Carrington, Marcus Altfeld
The activating natural killer (NK)-cell receptor KIR3DS1 has been linked to the outcome of various human diseases, including delayed progression of disease caused by human immunodeficiency virus type 1 (HIV-1), yet a ligand that would account for its biological effects has remained unknown. We screened 100 HLA class I proteins and found that KIR3DS1 bound to HLA-F, a result we confirmed biochemically and functionally. Primary human KIR3DS1(+) NK cells degranulated and produced antiviral cytokines after encountering HLA-F and inhibited HIV-1 replication in vitro...
September 2016: Nature Immunology
Mausumi Dikpati, Akshaya Suresh, Joan Burkepile
The structure of the Sun's corona varies with the solar-cycle phase, from a near spherical symmetry at solar maximum to an axial dipole at solar minimum. It is widely accepted that the large-scale coronal structure is governed by magnetic fields that are most likely generated by dynamo action in the solar interior. In order to understand the variation in coronal structure, we couple a potential-field source-surface model with a cyclic dynamo model. In this coupled model, the magnetic field inside the convection zone is governed by the dynamo equation; these dynamo-generated fields are extended from the photosphere to the corona using a potential-field source-surface model...
2016: Solar Physics
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