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https://www.readbyqxmd.com/read/29454775/left-ventricular-dysfunction-and-exercise-capacity-trajectory-implications-for-subclinical-heart-failure-staging-criteria
#1
Julian W Sacre, Chiew Wong, Yih-Kai Chan, Melinda J Carrington, Simon Stewart, Bronwyn A Kingwell
OBJECTIVES: This study aimed to determine the association of stage B heart failure (SBHF) and its constituent left ventricular (LV) abnormalities with trajectory of exercise capacity over time, and assess whether this association is modified by reversion of these LV abnormalities to normal. BACKGROUND: The LV abnormalities of SBHF may coincide with a reduction in exercise capacity that precedes the overt exercise intolerance of clinical heart failure (HF). Determining the predictive capacity of established and novel SBHF criteria for exercise capacity decline may improve HF risk stratification...
February 9, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29424274/two-strategies-for-qualitative-content-analysis-an-intramethod-approach-to-triangulation
#2
Susan M Renz, Jane M Carrington, Terry A Badger
The overarching aim of qualitative research is to gain an understanding of certain social phenomena. Qualitative research involves the studied use and collection of empirical materials, all to describe moments and meanings in individuals' lives. Data derived from these various materials require a form of analysis of the content, focusing on written or spoken language as communication, to provide context and understanding of the message. Qualitative research often involves the collection of data through extensive interviews, note taking, and tape recording...
February 1, 2018: Qualitative Health Research
https://www.readbyqxmd.com/read/29390829/a-new-collocation-based-multi-configuration-time-dependent-hartree-mctdh-approach-for-solving-the-schr%C3%A3-dinger-equation-with-a-general-potential-energy-surface
#3
Robert Wodraszka, Tucker Carrington
We present a new collocation-based multi-configuration time-dependent Hartree (MCTDH) approach for solving the Schrödinger equation required to compute (ro-)vibrational spectra, photodissociation cross sections, reaction rate constants, etc., that can be used with general potential energy surfaces. Collocation obviates the need for quadrature and facilitates using complicated kinetic energy operators. When the basis is good, the accuracy of collocation solutions to the Schrödinger equation is not sensitive to the choice of the collocation points...
January 28, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29358741/the-structure-of-serum-resistance-associated-protein-and-its-implications-for-human-african-trypanosomiasis
#4
Sebastian Zoll, Harriet Lane-Serff, Shahid Mehmood, Jonathan Schneider, Carol V Robinson, Mark Carrington, Matthew K Higgins
Only two trypanosome subspecies are able to cause human African trypanosomiasis. To establish an infection in human blood, they must overcome the innate immune system by resisting the toxic effects of trypanolytic factor 1 and trypanolytic factor 2 (refs. 1,2). These lipoprotein complexes contain an active, pore-forming component, apolipoprotein L1 (ApoL1), that causes trypanosome cell death 3 . One of the two human-infective subspecies, Trypanosoma brucei rhodesiense, differs from non-infective trypanosomes solely by the presence of the serum resistance-associated protein, which binds directly to ApoL1 and blocks its pore-forming capacity3-5...
January 22, 2018: Nature Microbiology
https://www.readbyqxmd.com/read/29358286/aberrant-trna-processing-causes-an-autoinflammatory-syndrome-responsive-to-tnf-inhibitors
#5
Angeliki Giannelou, Hongying Wang, Qing Zhou, Yong Hwan Park, Mones S Abu-Asab, Kris Ylaya, Deborah L Stone, Anna Sediva, Rola Sleiman, Lucie Sramkova, Deepika Bhatla, Elisavet Serti, Wanxia Li Tsai, Dan Yang, Kevin Bishop, Blake Carrington, Wuhong Pei, Natalie Deuitch, Stephen Brooks, Jehad H Edwan, Sarita Joshi, Seraina Prader, Daniela Kaiser, William C Owen, Abdullah Al Sonbul, Yu Zhang, Julie E Niemela, Shawn M Burgess, Manfred Boehm, Barbara Rehermann, JaeJin Chae, Martha M Quezado, Amanda K Ombrello, Rebecca H Buckley, Alexi A Grom, Elaine F Remmers, Jana M Pachlopnik, Helen C Su, Gustavo Gutierrez-Cruz, Stephen M Hewitt, Raman Sood, Kimberly Risma, Katherine R Calvo, Sergio D Rosenzweig, Massimo Gadina, Markus Hafner, Hong-Wei Sun, Daniel L Kastner, Ivona Aksentijevich
OBJECTIVES: To characterise the clinical features, immune manifestations and molecular mechanisms in a recently described autoinflammatory disease caused by mutations in TRNT1, a tRNA processing enzyme, and to explore the use of cytokine inhibitors in suppressing the inflammatory phenotype. METHODS: We studied nine patients with biallelic mutations in TRNT1 and the syndrome of congenital sideroblastic anaemia with immunodeficiency, fevers and developmental delay (SIFD)...
January 22, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29330364/polypharmacy-through-phage-display-selection-of-glucagon-and-glp-1-receptor-co-agonists-from-a-phage-displayed-peptide-library
#6
Anna Demartis, Armin Lahm, Licia Tomei, Elisa Beghetto, Valentina Di Biasio, Federica Orvieto, Francesco Frattolillo, Paul E Carrington, Sheena Mumick, Brian Hawes, Elisabetta Bianchi, Anandan Palani, Antonello Pessi
A promising emerging area for the treatment of obesity and diabetes is combinatorial hormone therapy, where single-molecule peptides are rationally designed to integrate the complementary actions of multiple endogenous metabolically-related hormones. We describe here a proof-of-concept study on developing unimolecular polypharmacy agents through the use of selection methods based on phage-displayed peptide libraries (PDL). Co-agonists of the glucagon (GCG) and GLP-1 receptors were identified from a PDL sequentially selected on GCGR- and GLP1R-overexpressing cells...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329284/identification-of-an-elaborate-nk-specific-system-regulating-hla-c-expression
#7
Hongchuan Li, Martin A Ivarsson, Victoria E Walker-Sperling, Jeff Subleski, Jenna K Johnson, Paul W Wright, Mary Carrington, Niklas K Björkström, Daniel W McVicar, Stephen K Anderson
The HLA-C gene appears to have evolved in higher primates to serve as a dominant source of ligands for the KIR2D family of inhibitory MHC class I receptors. The expression of NK cell-intrinsic MHC class I has been shown to regulate the murine Ly49 family of MHC class I receptors due to the interaction of these receptors with NK cell MHC in cis. However, cis interactions have not been demonstrated for the human KIR and HLA proteins. We report the discovery of an elaborate NK cell-specific system regulating HLA-C expression, indicating an important role for HLA-C in the development and function of NK cells...
January 12, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29321499/may-measurement-month-2017-a-concerted-global-effort-to-raise-awareness-of-elevated-blood-pressure
#8
REVIEW
Markus P Schlaich, Melinda Carrington
No abstract text is available yet for this article.
January 10, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29302013/elevated-hla-a-expression-impairs-hiv-control-through-inhibition-of-nkg2a-expressing-cells
#9
Veron Ramsuran, Vivek Naranbhai, Amir Horowitz, Ying Qi, Maureen P Martin, Yuko Yuki, Xiaojiang Gao, Victoria Walker-Sperling, Gregory Q Del Prete, Douglas K Schneider, Jeffrey D Lifson, Jacques Fellay, Steven G Deeks, Jeffrey N Martin, James J Goedert, Steven M Wolinsky, Nelson L Michael, Gregory D Kirk, Susan Buchbinder, David Haas, Thumbi Ndung'u, Philip Goulder, Peter Parham, Bruce D Walker, Jonathan M Carlson, Mary Carrington
The highly polymorphic human leukocyte antigen (HLA) locus encodes cell surface proteins that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner, diversifying allele-specific effects beyond peptide-binding preference. Analysis of 9763 HIV-infected individuals from 21 cohorts shows that higher HLA-A levels confer poorer control of HIV. Elevated HLA-A expression provides enhanced levels of an HLA-A-derived signal peptide that specifically binds and determines expression levels of HLA-E, the ligand for the inhibitory NKG2A natural killer (NK) cell receptor...
January 5, 2018: Science
https://www.readbyqxmd.com/read/29298494/development-of-a-community-based-palliative-care-screening-tool-for-underserved-older-adults-with-chronic-illnesses
#10
Angela Ghesquiere, Daniel S Gardner, Caitlin McAfee, Cara Kenien, Elizabeth Capezuti, Elissa Kozlov, Jo Anne Sirey, M Carrington Reid
Although they experience high rates of chronic illness, low-income minority communities have traditionally underutilized palliative care services compared to whites and those with higher incomes. One reason for this trend is lack of screening by community providers. We utilized a community-based participatory research approach to develop and implement an innovative multidomain palliative care screening tool in aging service agencies. Participants were aging service providers and clients in the East and Central Harlem neighborhoods of New York City, which are characterized by high poverty, largely African American and Latino populations, disproportionally high rates of chronic conditions, and limited health-care access...
January 1, 2018: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29290303/serological-evidence-for-eight-globally-important-poultry-viruses-in-trinidad-tobago
#11
Arianne Brown Jordan, Jamie Sookhoo, Lemar Blake, Paul Crooks, Zul Mohammed, Judy Molawatti-Bisnath, Christine V F Carrington, Christopher A L Oura
Viruses affecting poultry cause significant levels of disease leading to severe economic losses among poultry farmers worldwide. The Americas region continues to be vulnerable to the spread of poultry viruses across the continents and Caribbean island chains. In Trinidad and Tobago (T&T) there is limited information on the viruses circulating in poultry. Many flock are vulnerable to infection and there are occasional outbreaks of disease resulting in high levels of morbidity and mortality. This study aims to identify important viruses of poultry circulating in T&T through a broad-based surveillance approach...
January 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29288535/macroalgal-spore-dysfunction-ocean-acidification-delays-and-weakens-adhesion
#12
Rebecca Guenther, Kevin Miklasz, Emily Carrington, Patrick T Martone
Early life stages of marine organisms are predicted to be vulnerable to ocean acidification. For macroalgae, reproduction and population persistence rely on spores to settle, adhere and continue the algal life cycle, yet the effect of ocean acidification on this critical life stage has been largely overlooked. We explicitly tested the biomechanical impact of reduced pH on early spore adhesion. We developed a shear flume to examine the effect of reduced pH on spore attachment time and strength in two intertidal rhodophyte macroalgae, one calcified (Corallina vancouveriensis) and one non-calcified (Polyostea robusta)...
December 29, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/29279375/field-and-clinically-derived-estimates-of-wolbachia-mediated-blocking-of-dengue-virus-transmission-potential-in-aedes-aegypti-mosquitoes
#13
Lauren B Carrington, Bich Chau Nguyen Tran, Nhat Thanh Hoang Le, Tai Thi Hue Luong, Truong Thanh Nguyen, Phong Thanh Nguyen, Chau Van Vinh Nguyen, Huong Thi Cam Nguyen, Trung Tuan Vu, Long Thi Vo, Dui Thi Le, Nhu Tuyet Vu, Giang Thi Nguyen, Hung Quoc Luu, Anh Duc Dang, Timothy P Hurst, Scott L O'Neill, Vi Thuy Tran, Duong Thi Hue Kien, Nguyet Minh Nguyen, Marcel Wolbers, Bridget Wills, Cameron P Simmons
The wMel strain of Wolbachia can reduce the permissiveness of Aedes aegypti mosquitoes to disseminated arboviral infections. Here, we report that wMel-infected Ae. aegypti (Ho Chi Minh City background), when directly blood-fed on 141 viremic dengue patients, have lower dengue virus (DENV) transmission potential and have a longer extrinsic incubation period than their wild-type counterparts. The wMel-infected mosquitoes that are field-reared have even greater relative resistance to DENV infection when fed on patient-derived viremic blood meals...
December 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29249620/moving-beyond-pain-as-the-fifth-vital-sign-and-patient-satisfaction-scores-to-improve-pain-care-in-the-21st-century
#14
REVIEW
Clara Scher, Lauren Meador, Janet H Van Cleave, M Carrington Reid
No abstract text is available yet for this article.
December 14, 2017: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/29237835/hla-class-i-mediated-hiv-1-control-in-vietnamese-infected-with-hiv-1-subtype-a-e
#15
Takayuki Chikata, Giang Van Tran, Hayato Murakoshi, Tomohiro Akahoshi, Ying Qi, Vivek Naranbhai, Nozomi Kuse, Yoshiko Tamura, Madoka Koyanagi, Sachiko Sakai, Dung Hoai Nguyen, Dung Thi Nguyen, Ha Thu Nguyen, Trung Vu Nguyen, Shinichi Oka, Maureen P Martin, Mary Carrington, Keiko Sakai, Kinh Van Nguyen, Masafumi Takiguchi
HIV-1-specific cytotoxic T cells (CTLs) play an important role in the control of HIV-1 subtype B or C infection. However, the role of CTLs in HIV-1 subtype A/E infection still remains unclear. Here we investigated the association of HLA class I alleles with clinical outcome in treatment-naïve Vietnamese infected with subtype A/E. We found that HLA-C*12:02 was significantly associated with lower pVL and higher CD4 count and that the HLA-A*29:01-B*07:05-C*15:05 haplotype was significantly associated with higher pVL and lower CD4 count as compared to individuals without these respective genotypes...
December 13, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29212477/nurse-health-and-lifestyle-modification-versus-standard-care-in-40-to-70-year-old-regional-adults-study-protocol-of-the-management-to-optimise-diabetes-and-metabolic-syndrome-risk-reduction-via-nurse-led-intervention-modern-randomized-controlled-trial
#16
Melinda J Carrington, Paul Zimmet
BACKGROUND: Metabolic syndrome (MetS), the clustering of multiple leading risk factors, predisposes individuals to increased risk for developing type 2 diabetes and/or cardiovascular disease (CVD). Cardio-metabolic disease risk increases with greater remoteness where specialist services are scarce. Nurse-led interventions are effective for the management of chronic disease. The aim of this clinical trial is to determine whether a nurse-implemented health and lifestyle modification program is more beneficial than standard care to reduce cardio-metabolic abnormalities and future risk of CVD and diabetes in individuals with MetS...
December 6, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29212346/palliative-care-providers-practices-surrounding-psychological-distress-screening-and-treatment-a-national-survey
#17
Elissa Kozlov, Claude Eghan, Sheila Moran, Keela Herr, M Carrington Reid
OBJECTIVE: To investigate how inpatient palliative care teams nationwide currently screen for and treat psychological distress. METHODS: A web-based survey was sent to inpatient palliative care providers of all disciplines nationwide asking about their practice patterns regarding psychological assessment and treatment. Descriptive statistics were used to characterize the sample and responses, and analysis of variance was conducted to determine whether certain disciplines were more likely to utilize specific treatment modalities...
January 1, 2017: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29194338/nurses-use-of-positive-deviance-when-encountering-electronic-health-records-related-unintended-consequences
#18
Alycia A Bristol, Christine W Nibbelink, Sheila M Gephart, Jane M Carrington
As organizations adopt electronic health records (EHRs), nurses frequently encounter system barriers and difficulty performing role expectations. This article describes nurses' experiences with unintended consequences emerging from the use of an EHR. In some situations, nurses were positively deviant when encountering unintended consequences relating to EHRs to accomplish patient care or protect patient safety. Nurses engaged in work-arounds to provide patient care when the EHR did not meet their needs, sometimes in positively deviant ways...
January 2018: Nursing Administration Quarterly
https://www.readbyqxmd.com/read/29194056/neonatal-nurses-experience-unintended-consequences-and-risks-to-patient-safety-with-electronic-health-records
#19
Katherine M Dudding, Sheila M Gephart, Jane M Carrington
In this article, we examine the unintended consequences of nurses' use of electronic health records. We define these as unforeseen events, change in workflow, or an unanticipated result of implementation and use of electronic health records. Unintended consequences experienced by nurses while using electronic health records have been well researched. However, few studies have focused on neonatal nurses, and it is unclear to what extent unintended consequences threaten patient safety. A new instrument called the Carrington-Gephart Unintended Consequences of Electronic Health Record Questionnaire has been validated, and secondary analysis using the tool explored the phenomena among neonatal nurses (N = 40)...
November 30, 2017: Computers, Informatics, Nursing: CIN
https://www.readbyqxmd.com/read/29191016/room-temperature-mid-infrared-emission-from-faceted-inassb-multi-quantum-wells-embedded-in-inas-nanowires
#20
Aiyeshah Alhodaib, Yasir Noori, Peter J Carrington, Ana M Sanchez, Michael Dermot Thompson, Robert J Young, Anthony Krier, Andrew Marshall
There is considerable interest in the development of InAsSb based nanowires for infrared photonics due to their high tunability across the infrared spectral range, high mobility and integration with silicon electronics. However, optical emission is currently limited to low temperatures due to strong non-radiative Auger and surface recombination. Here, we present a new structure based on conical type II InAsSb/InAs multi-quantum wells within InAs nanowires which exhibit bright mid-infrared photoluminescence up to room temperature...
November 30, 2017: Nano Letters
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