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JOURNAL ARTICLE
Cassandra M J Wannan, Barnaby Nelson, Jean Addington, Kelly Allott, Alan Anticevic, Celso Arango, Justin T Baker, Carrie E Bearden, Tashrif Billah, Sylvain Bouix, Matthew R Broome, Kate Buccilli, Kristin S Cadenhead, Monica E Calkins, Tyrone D Cannon, Guillermo Cecci, Eric Yu Hai Chen, Kang Ik K Cho, Jimmy Choi, Scott R Clark, Michael J Coleman, Philippe Conus, Cheryl M Corcoran, Barbara A Cornblatt, Covadonga M Diaz-Caneja, Dominic Dwyer, Bjørn H Ebdrup, Lauren M Ellman, Paolo Fusar-Poli, Liliana Galindo, Pablo A Gaspar, Carla Gerber, Louise Birkedal Glenthøj, Robert Glynn, Michael P Harms, Leslie E Horton, René S Kahn, Joseph Kambeitz, Lana Kambeitz-Ilankovic, John M Kane, Tina Kapur, Matcheri S Keshavan, Sung-Wan Kim, Nikolaos Koutsouleris, Marek Kubicki, Jun Soo Kwon, Kerstin Langbein, Kathryn E Lewandowski, Gregory A Light, Daniel Mamah, Patricia J Marcy, Daniel H Mathalon, Patrick D McGorry, Vijay A Mittal, Merete Nordentoft, Angela Nunez, Ofer Pasternak, Godfrey D Pearlson, Jesus Perez, Diana O Perkins, Albert R Powers, David R Roalf, Fred W Sabb, Jason Schiffman, Jai L Shah, Stefan Smesny, Jessica Spark, William S Stone, Gregory P Strauss, Zailyn Tamayo, John Torous, Rachel Upthegrove, Mark Vangel, Swapna Verma, Jijun Wang, Inge Winter-van Rossum, Daniel H Wolf, Phillip Wolff, Stephen J Wood, Alison R Yung, Carla Agurto, Mario Alvarez-Jimenez, Paul Amminger, Marco Armando, Ameneh Asgari-Targhi, John Cahill, Ricardo E Carrión, Eduardo Castro, Suheyla Cetin-Karayumak, M Mallar Chakravarty, Youngsun T Cho, David Cotter, Simon D'Alfonso, Michaela Ennis, Shreyas Fadnavis, Clara Fonteneau, Caroline Gao, Tina Gupta, Raquel E Gur, Ruben C Gur, Holly K Hamilton, Gil D Hoftman, Grace R Jacobs, Johanna Jarcho, Jie Lisa Ji, Christian G Kohler, Paris Alexandros Lalousis, Suzie Lavoie, Martin Lepage, Einat Liebenthal, Josh Mervis, Vishnu Murty, Spero C Nicholas, Lipeng Ning, Nora Penzel, Russell Poldrack, Pablo Polosecki, Danielle N Pratt, Rachel Rabin, Habiballah Rahimi Eichi, Yogesh Rathi, Avraham Reichenberg, Jenna Reinen, Jack Rogers, Bernalyn Ruiz-Yu, Isabelle Scott, Johanna Seitz-Holland, Vinod H Srihari, Agrima Srivastava, Andrew Thompson, Bruce I Turetsky, Barbara C Walsh, Thomas Whitford, Johanna T W Wigman, Beier Yao, Hok Pan Yuen, Uzair Ahmed, Andrew Jin Soo Byun, Yoonho Chung, Kim Do, Larry Hendricks, Kevin Huynh, Clark Jeffries, Erlend Lane, Carsten Langholm, Eric Lin, Valentina Mantua, Gennarina Santorelli, Kosha Ruparel, Eirini Zoupou, Tatiana Adasme, Lauren Addamo, Laura Adery, Munaza Ali, Andrea Auther, Samantha Aversa, Seon-Hwa Baek, Kelly Bates, Alyssa Bathery, Johanna M M Bayer, Rebecca Beedham, Zarina Bilgrami, Sonia Birch, Ilaria Bonoldi, Owen Borders, Renato Borgatti, Lisa Brown, Alejandro Bruna, Holly Carrington, Rolando I Castillo-Passi, Justine Chen, Nicholas Cheng, Ann Ee Ching, Chloe Clifford, Beau-Luke Colton, Pamela Contreras, Sebastián Corral, Stefano Damiani, Monica Done, Andrés Estradé, Brandon Asika Etuka, Melanie Formica, Rachel Furlan, Mia Geljic, Carmela Germano, Ruth Getachew, Mathias Goncalves, Anastasia Haidar, Jessica Hartmann, Anna Jo, Omar John, Sarah Kerins, Melissa Kerr, Irena Kesselring, Honey Kim, Nicholas Kim, Kyle Kinney, Marija Krcmar, Elana Kotler, Melanie Lafanechere, Clarice Lee, Joshua Llerena, Christopher Markiewicz, Priya Matnejl, Alejandro Maturana, Aissata Mavambu, Rocío Mayol-Troncoso, Amelia McDonnell, Alessia McGowan, Danielle McLaughlin, Rebecca McIlhenny, Brittany McQueen, Yohannes Mebrahtu, Martina Mensi, Christy Lai Ming Hui, Yi Nam Suen, Stephanie Ming Yin Wong, Neal Morrell, Mariam Omar, Alice Partridge, Christina Phassouliotis, Anna Pichiecchio, Pierluigi Politi, Christian Porter, Umberto Provenzani, Nicholas Prunier, Jasmine Raj, Susan Ray, Victoria Rayner, Manuel Reyes, Kate Reynolds, Sage Rush, Cesar Salinas, Jashmina Shetty, Callum Snowball, Sophie Tod, Gabriel Turra-Fariña, Daniela Valle, Simone Veale, Sarah Whitson, Alana Wickham, Sarah Youn, Francisco Zamorano, Elissa Zavaglia, Jamie Zinberg, Scott W Woods, Martha E Shenton
This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community...
March 7, 2024: Schizophrenia Bulletin
#2
JOURNAL ARTICLE
Zhiwei Liu, Yang Luo, Samuel Kirimunda, Murielle Verboom, Olusegun O Onabajo, Mateus H Gouveia, Martin D Ogwang, Patrick Kerchan, Steven J Reynolds, Constance N Tenge, Pamela A Were, Robert T Kuremu, Walter N Wekesa, Nestory Masalu, Esther Kawira, Tobias Kinyera, Isaac Otim, Ismail D Legason, Hadijah Nabalende, Herry Dhudha, Leona W Ayers, Kishor Bhatia, James J Goedert, Nathan Cole, Wen Luo, Jia Liu, Michelle Manning, Belynda Hicks, Ludmila Prokunina-Olsson, George Chagaluka, W Thomas Johnston, Nora Mutalima, Eric Borgstein, George N Liomba, Steve Kamiza, Nyengo Mkandawire, Collins Mitambo, Elizabeth M Molyneux, Robert Newton, Ann W Hsing, James E Mensah, Anthony A Adjei, Amy Hutchinson, Mary Carrington, Meredith Yeager, Rainer Blasczyk, Stephen J Chanock, Soumya Raychaudhuri, Sam M Mbulaiteye
Burkitt lymphoma (BL) is responsible for many childhood cancers in sub-Saharan Africa, where it is linked to recurrent or chronic infection by Epstein-Barr virus or Plasmodium falciparum. However, whether human leukocyte antigen (HLA) polymorphisms, which regulate immune response, are associated with BL has not been well investigated, which limits our understanding of BL etiology. Here we investigate this association among 4,645 children aged 0-15 years, 800 with BL, enrolled in Uganda, Tanzania, Kenya, and Malawi...
January 5, 2024: Communications Biology
#3
JOURNAL ARTICLE
Deborah Persaud, Yvonne Bryson, Bryan S Nelson, Camlin Tierney, Mark F Cotton, Anne Coletti, Jennifer Jao, Stephen A Spector, Mark Mirochnick, Edmund V Capparelli, Diane Costello, Joseph Szewczyk, Nicol Nicodimus, Lynda Stranix-Chibanda, Adeodata R Kekitiinwa, Violet Korutaro, Christina Reding, Mary N Carrington, Sai Majji, Dwight E Yin, Patrick Jean-Philippe, Ellen G Chadwick
BACKGROUND: Infants born with HIV-1 require lifelong antiretroviral therapy (ART). We aimed to assess whether very early ART in neonates might restrict HIV-1 reservoirs, an important step towards ART-free remission. METHODS: IMPAACT P1115 is an ongoing, phase 1/2, proof-of-concept study in which infants were enrolled at 30 research clinics in 11 countries (Brazil, Haiti, Kenya, Malawi, South Africa, Tanzania, Thailand, Uganda, the USA, Zambia, and Zimbabwe) into two cohorts...
January 2024: Lancet HIV
#4
JOURNAL ARTICLE
Cheng-Hsin Wei, Lu Huang, Blair Kreh, Xiuxia Liu, Liliya Tyutyunyk-Massey, Masanori Kawakami, Zibo Chen, Mi Shi, Serguei Kozlov, King C Chan, Thorkell Andresson, Mary Carrington, Vidyasagar Vuligonda, Martin E Sanders, Amir Horowitz, Patrick Hwu, Weiyi Peng, Ethan Dmitrovsky, Xi Liu
All-trans-retinoic acid (ATRA), the retinoic acid receptors (RARs) agonist, regulates cell growth, differentiation, immunity, and survival. We report that ATRA-treatment repressed cancer growth in syngeneic immunocompetent, but not immunodeficient mice. The tumor microenvironment was implicated: CD8+ T cell depletion antagonized ATRA's anti-tumorigenic effects in syngeneic mice. ATRA-treatment with checkpoint blockade did not cooperatively inhibit murine lung cancer growth. To augment ATRA's anti-tumorigenicity without promoting its pro-tumorigenic potential, an RARγ agonist (IRX4647) was used since it regulates T cell biology...
September 9, 2023: Scientific Reports
#5
JOURNAL ARTICLE
Ciputra Adijaya Hartana, Pilar Garcia-Broncano, Yelizaveta Rassadkina, Xiaodong Lian, Chenyang Jiang, Kevin B Einkauf, Kenneth Maswabi, Gbolahan Ajibola, Sikhulile Moyo, Terence Mohammed, Comfort Maphorisa, Joseph Makhema, Yuko Yuki, Maureen Martin, Kara Bennett, Patrick Jean-Philippe, Mathias Viard, Michael D Hughes, Kathleen M Powis, Mary Carrington, Shahin Lockman, Ce Gao, Xu G Yu, Daniel R Kuritzkes, Roger Shapiro, Mathias Lichterfeld
Initiation of antiretroviral therapy (ART) in infected neonates within hours after birth limits viral reservoir seeding but does not prevent long-term HIV-1 persistence. Here, we report parallel assessments of HIV-1 reservoir cells and innate antiviral immune responses in a unique cohort of 37 infected neonates from Botswana who started ART extremely early, frequently within hours after birth. Decline of genome-intact HIV-1 proviruses occurs rapidly after initiation of ART and is associated with an increase in natural killer (NK) cell populations expressing the cytotoxicity marker CD57 and with a decrease in NK cell subsets expressing the inhibitory marker NKG2A...
July 19, 2022: Cell Reports
#6
JOURNAL ARTICLE
Joshua M Francis, Del Leistritz-Edwards, Augustine Dunn, Christina Tarr, Jesse Lehman, Conor Dempsey, Andrew Hamel, Violeta Rayon, Gang Liu, Yuntong Wang, Marcos Wille, Melissa Durkin, Kane Hadley, Aswathy Sheena, Benjamin Roscoe, Mark Ng, Graham Rockwell, Margaret Manto, Elizabeth Gienger, Joshua Nickerson, Amir Moarefi, Michael Noble, Thomas Malia, Philip D Bardwell, William Gordon, Joanna Swain, Mojca Skoberne, Karsten Sauer, Tim Harris, Ananda W Goldrath, Alex K Shalek, Anthony J Coyle, Christophe Benoist, Daniel C Pregibon
Effective presentation of antigens by human leukocyte antigen (HLA) class I molecules to CD8+ T cells is required for viral elimination and generation of long-term immunological memory. In this study, we applied a single-cell, multiomic technology to generate a unified ex vivo characterization of the CD8+ T cell response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) across four major HLA class I alleles. We found that HLA genotype conditions key features of epitope specificity, TCRα/β sequence diversity, and the utilization of pre-existing SARS-CoV-2-reactive memory T cell pools...
January 21, 2022: Science Immunology
#7
JOURNAL ARTICLE
Catherine Riffin, Karlee Patrick, Sylvia L Lin, M Carrington Reid, Keela Herr, Karl A Pillemer
BACKGROUND: Pain in older persons with dementia is both under-detected and under-managed. Family caregivers can play an important role in addressing these deficiencies by communicating their care recipient's symptoms and behaviors to medical providers, but little is known about how caregivers and providers approach pain-related discussions in the context of dementia. The goal of this study was to explore how ambulatory care providers and family caregivers of persons with dementia view pain communication...
August 2, 2021: Dementia
#8
REVIEW
Timothy E Higham, Lara A Ferry, Lars Schmitz, Duncan J Irschick, Samuel Starko, Philip S L Anderson, Philip J Bergmann, Heather A Jamniczky, Leandro R Monteiro, Dina Navon, Julie Messier, Emily Carrington, Stacy C Farina, Kara L Feilich, L Patricia Hernandez, Michele A Johnson, Sandy M Kawano, Chris J Law, Sarah J Longo, Christopher H Martin, Patrick T Martone, Alejandro Rico-Guevara, Sharlene E Santana, Karl J Niklas
Physical principles and laws determine the set of possible organismal phenotypes. Constraints arising from development, the environment, and evolutionary history then yield workable, integrated phenotypes. We propose a theoretical and practical framework that considers the role of changing environments. This 'ecomechanical approach' integrates functional organismal traits with the ecological variables. This approach informs our ability to predict species shifts in survival and distribution and provides critical insights into phenotypic diversity...
June 24, 2021: Trends in Ecology & Evolution
#9
JOURNAL ARTICLE
Katarzyna Pluta, Peter R H Jones, Natalia Drabińska, Norman Ratcliffe, Stephen D Carrington, Patrick Lonergan, Alexander C O Evans
Cervicovaginal mucus is a mixture of mucins, ions, salts, and water, the proportions of which change during the reproductive cycle. It is suspected that this mucus emits an important volatile signal indicative of the reproductive state of the female. The objective of this study was to identify volatile organic compounds (VOC) in bovine cervicovaginal mucus that are modulated during the estrous cycle and could potentially be used as biomarkers of estrus and ovulation. Cervicovaginal mucus was collected from crossbred beef heifers (n = 8), which were synchronized using an 8-d controlled internal drug release (CIDR) protocol and in which onset of estrus and time of ovulation were determined by visual observation and ultrasonography, respectively...
November 11, 2020: Journal of Dairy Science
#10
JOURNAL ARTICLE
Stavros Trakoshis, Pablo Martínez-Cañada, Federico Rocchi, Carola Canella, Wonsang You, Bhismadev Chakrabarti, Amber Nv Ruigrok, Edward T Bullmore, John Suckling, Marija Markicevic, Valerio Zerbi, Anthony J Bailey, Simon Baron-Cohen, Patrick F Bolton, Edward T Bullmore, Sarah Carrington, Marco Catani, Bhismadev Chakrabarti, Michael C Craig, Eileen M Daly, Sean Cl Deoni, Christine Ecker, Francesca Happé, Julian Henty, Peter Jezzard, Patrick Johnston, Derek K Jones, Meng-Chuan Lai, Michael V Lombardo, Anya Madden, Diane Mullins, Clodagh M Murphy, Declan Gm Murphy, Greg Pasco, Amber Nv Ruigrok, Susan A Sadek, Debbie Spain, Rose Stewart, John Suckling, Sally J Wheelwright, Steven C Williams, Simon Baron-Cohen, Alessandro Gozzi, Meng-Chuan Lai, Stefano Panzeri, Michael V Lombardo
Excitation-inhibition (E:I) imbalance is theorized as an important pathophysiological mechanism in autism. Autism affects males more frequently than females and sex-related mechanisms (e.g., X-linked genes, androgen hormones) can influence E:I balance. This suggests that E:I imbalance may affect autism differently in males versus females. With a combination of in-silico modeling and in-vivo chemogenetic manipulations in mice, we first show that a time-series metric estimated from fMRI BOLD signal, the Hurst exponent (H), can be an index for underlying change in the synaptic E:I ratio...
August 4, 2020: ELife
#11
JOURNAL ARTICLE
Oliver Patrick Devine, Andrew Christopher Harborne, Hugo Layard Horsfall, Tobin Joseph, Tess Marshall-Andon, Ryan Samuels, Joshua William Kearsley, Nadine Abbas, Hassan Baig, Joseph Beecham, Natasha Benons, Charlie Caird, Ryan Clark, Thomas Cope, James Coultas, Luke Debenham, Sarah Douglas, Jack Eldridge, Thomas Hughes-Gooding, Agnieszka Jakubowska, Oliver Jones, Eve Lancaster, Calum MacMillan, Ross McAllister, Wassim Merzougui, Ben Phillips, Simon Phillips, Omar Risk, Adam Sage, Aisha Sooltangos, Robert Spencer, Roxanne Tajbakhsh, Oluseyi Adesalu, Ivan Aganin, Ammar Ahmed, Katherine Aiken, Alimatu-Sadia Akeredolu, Ibrahim Alam, Aamna Ali, Richard Anderson, Jia Jun Ang, Fady Sameh Anis, Sonam Aojula, Catherine Arthur, Alena Ashby, Ahmed Ashraf, Emma Aspinall, Mark Awad, Abdul-Muiz Azri Yahaya, Shreya Badhrinarayanan, Soham Bandyopadhyay, Sam Barnes, Daisy Bassey-Duke, Charlotte Boreham, Rebecca Braine, Joseph Brandreth, Zoe Carrington, Zoe Cashin, Shaunak Chatterjee, Mehar Chawla, Chung Shen Chean, Chris Clements, Richard Clough, Jessica Coulthurst, Liam Curry, Vinnie Christine Daniels, Simon Davies, Rebecca Davis, Hanelie De Waal, Nasreen Desai, Hannah Douglas, James Druce, Lady-Namera Ejamike, Meron Esere, Alex Eyre, Ibrahim Talal Fazmin, Sophia Fitzgerald-Smith, Verity Ford, Sarah Freeston, Katherine Garnett, Whitney General, Helen Gilbert, Zein Gowie, Ciaran Grafton-Clarke, Keshni Gudka, Leher Gumber, Rishi Gupta, Chris Harlow, Amy Harrington, Adele Heaney, Wing Hang Serene Ho, Lucy Holloway, Christina Hood, Eleanor Houghton, Saba Houshangi, Emma Howard, Benjamin Human, Harriet Hunter, Ifrah Hussain, Sami Hussain, Richard Thomas Jackson-Taylor, Bronwen Jacob-Ramsdale, Ryan Janjuha, Saleh Jawad, Muzzamil Jelani, David Johnston, Mike Jones, Sadhana Kalidindi, Savraj Kalsi, Asanish Kalyanasundaram, Anna Kane, Sahaj Kaur, Othman Khaled Al-Othman, Qaisar Khan, Sajan Khullar, Priscilla Kirkland, Hannah Lawrence-Smith, Charlotte Leeson, Julius Elisabeth Richard Lenaerts, Kerry Long, Simon Lubbock, Jamie Mac Donald Burrell, Rachel Maguire, Praveen Mahendran, Saad Majeed, Prabhjot Singh Malhotra, Vinay Mandagere, Angelos Mantelakis, Sophie McGovern, Anjola Mosuro, Adam Moxley, Sophie Mustoe, Sam Myers, Kiran Nadeem, Reza Nasseri, Tom Newman, Richard Nzewi, Rosalie Ogborne, Joyce Omatseye, Sophie Paddock, James Parkin, Mohit Patel, Sohini Pawar, Stuart Pearce, Samuel Penrice, Julian Purdy, Raisa Ramjan, Ratan Randhawa, Usman Rasul, Elliot Raymond-Taggert, Rebecca Razey, Carmel Razzaghi, Eimear Reel, Elliot John Revell, Joanna Rigbye, Oloruntobi Rotimi, Abdelrahman Said, Emma Sanders, Pranoy Sangal, Nora Sangvik Grandal, Aadam Shah, Rahul Atul Shah, Oliver Shotton, Daniel Sims, Katie Smart, Martha Amy Smith, Nick Smith, Aninditya Salma Sopian, Matthew South, Jessica Speller, Tom J Syer, Ngan Hong Ta, Daniel Tadross, Benjamin Thompson, Jess Trevett, Matthew Tyler, Roshan Ullah, Mrudula Utukuri, Shree Vadera, Harriet Van Den Tooren, Sara Venturini, Aradhya Vijayakumar, Melanie Vine, Zoe Wellbelove, Liora Wittner, Geoffrey Hong Kiat Yong, Farris Ziyada, I C McManus
BACKGROUND: What subjects UK medical schools teach, what ways they teach subjects, and how much they teach those subjects is unclear. Whether teaching differences matter is a separate, important question. This study provides a detailed picture of timetabled undergraduate teaching activity at 25 UK medical schools, particularly in relation to problem-based learning (PBL). METHOD: The Analysis of Teaching of Medical Schools (AToMS) survey used detailed timetables provided by 25 schools with standard 5-year courses...
May 14, 2020: BMC Medicine
#12
JOURNAL ARTICLE
I C McManus, Andrew Christopher Harborne, Hugo Layard Horsfall, Tobin Joseph, Daniel T Smith, Tess Marshall-Andon, Ryan Samuels, Joshua William Kearsley, Nadine Abbas, Hassan Baig, Joseph Beecham, Natasha Benons, Charlie Caird, Ryan Clark, Thomas Cope, James Coultas, Luke Debenham, Sarah Douglas, Jack Eldridge, Thomas Hughes-Gooding, Agnieszka Jakubowska, Oliver Jones, Eve Lancaster, Calum MacMillan, Ross McAllister, Wassim Merzougui, Ben Phillips, Simon Phillips, Omar Risk, Adam Sage, Aisha Sooltangos, Robert Spencer, Roxanne Tajbakhsh, Oluseyi Adesalu, Ivan Aganin, Ammar Ahmed, Katherine Aiken, Alimatu-Sadia Akeredolu, Ibrahim Alam, Aamna Ali, Richard Anderson, Jia Jun Ang, Fady Sameh Anis, Sonam Aojula, Catherine Arthur, Alena Ashby, Ahmed Ashraf, Emma Aspinall, Mark Awad, Abdul-Muiz Azri Yahaya, Shreya Badhrinarayanan, Soham Bandyopadhyay, Sam Barnes, Daisy Bassey-Duke, Charlotte Boreham, Rebecca Braine, Joseph Brandreth, Zoe Carrington, Zoe Cashin, Shaunak Chatterjee, Mehar Chawla, Chung Shen Chean, Chris Clements, Richard Clough, Jessica Coulthurst, Liam Curry, Vinnie Christine Daniels, Simon Davies, Rebecca Davis, Hanelie De Waal, Nasreen Desai, Hannah Douglas, James Druce, Lady-Namera Ejamike, Meron Esere, Alex Eyre, Ibrahim Talal Fazmin, Sophia Fitzgerald-Smith, Verity Ford, Sarah Freeston, Katherine Garnett, Whitney General, Helen Gilbert, Zein Gowie, Ciaran Grafton-Clarke, Keshni Gudka, Leher Gumber, Rishi Gupta, Chris Harlow, Amy Harrington, Adele Heaney, Wing Hang Serene Ho, Lucy Holloway, Christina Hood, Eleanor Houghton, Saba Houshangi, Emma Howard, Benjamin Human, Harriet Hunter, Ifrah Hussain, Sami Hussain, Richard Thomas Jackson-Taylor, Bronwen Jacob-Ramsdale, Ryan Janjuha, Saleh Jawad, Muzzamil Jelani, David Johnston, Mike Jones, Sadhana Kalidindi, Savraj Kalsi, Asanish Kalyanasundaram, Anna Kane, Sahaj Kaur, Othman Khaled Al-Othman, Qaisar Khan, Sajan Khullar, Priscilla Kirkland, Hannah Lawrence-Smith, Charlotte Leeson, Julius Elisabeth Richard Lenaerts, Kerry Long, Simon Lubbock, Jamie Mac Donald Burrell, Rachel Maguire, Praveen Mahendran, Saad Majeed, Prabhjot Singh Malhotra, Vinay Mandagere, Angelos Mantelakis, Sophie McGovern, Anjola Mosuro, Adam Moxley, Sophie Mustoe, Sam Myers, Kiran Nadeem, Reza Nasseri, Tom Newman, Richard Nzewi, Rosalie Ogborne, Joyce Omatseye, Sophie Paddock, James Parkin, Mohit Patel, Sohini Pawar, Stuart Pearce, Samuel Penrice, Julian Purdy, Raisa Ramjan, Ratan Randhawa, Usman Rasul, Elliot Raymond-Taggert, Rebecca Razey, Carmel Razzaghi, Eimear Reel, Elliot John Revell, Joanna Rigbye, Oloruntobi Rotimi, Abdelrahman Said, Emma Sanders, Pranoy Sangal, Nora Sangvik Grandal, Aadam Shah, Rahul Atul Shah, Oliver Shotton, Daniel Sims, Katie Smart, Martha Amy Smith, Nick Smith, Aninditya Salma Sopian, Matthew South, Jessica Speller, Tom J Syer, Ngan Hong Ta, Daniel Tadross, Benjamin Thompson, Jess Trevett, Matthew Tyler, Roshan Ullah, Mrudula Utukuri, Shree Vadera, Harriet Van Den Tooren, Sara Venturini, Aradhya Vijayakumar, Melanie Vine, Zoe Wellbelove, Liora Wittner, Geoffrey Hong Kiat Yong, Farris Ziyada, Oliver Patrick Devine
BACKGROUND: Medical schools differ, particularly in their teaching, but it is unclear whether such differences matter, although influential claims are often made. The Medical School Differences (MedDifs) study brings together a wide range of measures of UK medical schools, including postgraduate performance, fitness to practise issues, specialty choice, preparedness, satisfaction, teaching styles, entry criteria and institutional factors. METHOD: Aggregated data were collected for 50 measures across 29 UK medical schools...
May 14, 2020: BMC Medicine
#13
JOURNAL ARTICLE
Titilope Badru, Jefferson Mwaisaka, Hadiza Khamofu, Chinedu Agbakwuru, Oluwasanmi Adedokun, Satish Raj Pandey, Patrick Essiet, Ezekiel James, Annie Chen-Carrington, Timothy D Mastro, Sani H Aliyu, Kwasi Torpey
BACKGROUND: Despite the recent increase in HIV infections among adolescents, little is known about their HIV knowledge and perceptions. This study, therefore, sought to examine the factors associated with comprehensive HIV knowledge, stigma, and HIV risk perceptions among young adolescents aged 10-14 years in Akwa Ibom State, Nigeria. Additionally, consenting parents and assenting young adolescents were tested for HIV. METHODS: We used cross-sectional data from the 2017 Akwa Ibom AIDS Indicator Survey to analyze comprehensive HIV knowledge, stigma, and HIV risk perceptions among young adolescents...
January 13, 2020: BMC Public Health
#14
JOURNAL ARTICLE
Janine F R Seetahal, Manuel J Sanchez-Vazquez, Alexandra Vokaty, Christine V F Carrington, Ron Mahabir, Abiodun A Adesiyun, Charles E Rupprecht
Vampire bat-transmitted human rabies was first recognized in Trinidad during a major outbreak during the first half of the 20th century. To date, Trinidad is the only Caribbean island with vampire bat-transmitted rabies. Herein, we summarized the epidemiological situation of rabies in Trinidad during the period 1971-2015 through the analysis of field and laboratory records. During the study period, 259 domestic and wild animal rabies cases were laboratory confirmed with an annual median of 2 animal rabies cases...
January 2019: Veterinary Microbiology
#15
JOURNAL ARTICLE
Maureen P Martin, Vivek Naranbhai, Patrick R Shea, Ying Qi, Veron Ramsuran, Nicolas Vince, Xiaojiang Gao, Rasmi Thomas, Zabrina L Brumme, Jonathan M Carlson, Steven M Wolinsky, James J Goedert, Bruce D Walker, Florencia P Segal, Steven G Deeks, David W Haas, Stephen A Migueles, Mark Connors, Nelson Michael, Jacques Fellay, Emma Gostick, Sian Llewellyn-Lacey, David A Price, Bernard A Lafont, Phillip Pymm, Philippa M Saunders, Jacqueline Widjaja, Shu Cheng Wong, Julian P Vivian, Jamie Rossjohn, Andrew G Brooks, Mary Carrington
HLA-B*57 control of HIV involves enhanced CD8+ T cell responses against infected cells, but extensive heterogeneity exists in the level of HIV control among B*57+ individuals. Using whole-genome sequencing of untreated B*57+ HIV-1-infected controllers and noncontrollers, we identified a single variant (rs643347A/G) encoding an isoleucine-to-valine substitution at position 47 (I47V) of the inhibitory killer cell immunoglobulin-like receptor KIR3DL1 as the only significant modifier of B*57 protection. The association was replicated in an independent cohort and across multiple outcomes...
May 1, 2018: Journal of Clinical Investigation
#16
LETTER
Rebecca Guenther, Kevin Miklasz, Emily Carrington, Patrick T Martone
Early life stages of marine organisms are predicted to be vulnerable to ocean acidification. For macroalgae, reproduction and population persistence rely on spores to settle, adhere and continue the algal life cycle, yet the effect of ocean acidification on this critical life stage has been largely overlooked. We explicitly tested the biomechanical impact of reduced pH on early spore adhesion. We developed a shear flume to examine the effect of reduced pH on spore attachment time and strength in two intertidal rhodophyte macroalgae, one calcified (Corallina vancouveriensis) and one noncalcified (Polyostea robusta)...
April 2018: Journal of Phycology
#17
RANDOMIZED CONTROLLED TRIAL
Bonnie Bowers, Randall Flory, Joseph Ametepe, Lauren Staley, Anne Patrick, Heather Carrington
This study evaluated the effectiveness of 30 or 60min of daily exposure to high-density or to zero-density (placebo condition) negative air ions over 18 days on the symptoms of seasonal affective disorder (SAD) in 40 participants under controlled laboratory conditions. Exposure to high-density negative air ions was superior to zero-density negative air ions in alleviating depression and the atypical symptoms of SAD. Also, more subjects in the high-density negative air ions groups met two different clinical response criteria than did those in the zero-density groups...
January 2018: Psychiatry Research
#18
JOURNAL ARTICLE
Wilson Leung, Christopher D Shaffer, Elizabeth J Chen, Thomas J Quisenberry, Kevin Ko, John M Braverman, Thomas C Giarla, Nathan T Mortimer, Laura K Reed, Sheryl T Smith, Srebrenka Robic, Shannon R McCartha, Danielle R Perry, Lindsay M Prescod, Zenyth A Sheppard, Ken J Saville, Allison McClish, Emily A Morlock, Victoria R Sochor, Brittney Stanton, Isaac C Veysey-White, Dennis Revie, Luis A Jimenez, Jennifer J Palomino, Melissa D Patao, Shane M Patao, Edward T Himelblau, Jaclyn D Campbell, Alexandra L Hertz, Maddison F McEvilly, Allison R Wagner, James Youngblom, Baljit Bedi, Jeffery Bettincourt, Erin Duso, Maiye Her, William Hilton, Samantha House, Masud Karimi, Kevin Kumimoto, Rebekah Lee, Darryl Lopez, George Odisho, Ricky Prasad, Holly Lyn Robbins, Tanveer Sandhu, Tracy Selfridge, Kara Tsukashima, Hani Yosif, Nighat P Kokan, Latia Britt, Alycia Zoellner, Eric P Spana, Ben T Chlebina, Insun Chong, Harrison Friedman, Danny A Mammo, Chun L Ng, Vinayak S Nikam, Nicholas U Schwartz, Thomas Q Xu, Martin G Burg, Spencer M Batten, Lindsay M Corbeill, Erica Enoch, Jesse J Ensign, Mary E Franks, Breanna Haiker, Judith A Ingles, Lyndsay D Kirkland, Joshua M Lorenz-Guertin, Jordan Matthews, Cody M Mittig, Nicholaus Monsma, Katherine J Olson, Guillermo Perez-Aragon, Alen Ramic, Jordan R Ramirez, Christopher Scheiber, Patrick A Schneider, Devon E Schultz, Matthew Simon, Eric Spencer, Adam C Wernette, Maxine E Wykle, Elizabeth Zavala-Arellano, Mitchell J McDonald, Kristine Ostby, Peter Wendland, Justin R DiAngelo, Alexis M Ceasrine, Amanda H Cox, James E B Docherty, Robert M Gingras, Stephanie M Grieb, Michael J Pavia, Casey L Personius, Grzegorz L Polak, Dale L Beach, Heaven L Cerritos, Edward A Horansky, Karim A Sharif, Ryan Moran, Susan Parrish, Kirsten Bickford, Jennifer Bland, Juliana Broussard, Kerry Campbell, Katelynn E Deibel, Richard Forka, Monika C Lemke, Marlee B Nelson, Catherine O'Keeffe, S Mariel Ramey, Luke Schmidt, Paola Villegas, Christopher J Jones, Stephanie L Christ, Sami Mamari, Adam S Rinaldi, Ghazal Stity, Amy T Hark, Mark Scheuerman, S Catherine Silver Key, Briana D McRae, Adam S Haberman, Sam Asinof, Harriette Carrington, Kelly Drumm, Terrance Embry, Richard McGuire, Drew Miller-Foreman, Stella Rosen, Nadia Safa, Darrin Schultz, Matt Segal, Yakov Shevin, Petros Svoronos, Tam Vuong, Gary Skuse, Don W Paetkau, Rachael K Bridgman, Charlotte M Brown, Alicia R Carroll, Francesca M Gifford, Julie Beth Gillespie, Susan E Herman, Krystal L Holtcamp, Misha A Host, Gabrielle Hussey, Danielle M Kramer, Joan Q Lawrence, Madeline M Martin, Ellen N Niemiec, Ashleigh P O'Reilly, Olivia A Pahl, Guadalupe Quintana, Elizabeth A S Rettie, Torie L Richardson, Arianne E Rodriguez, Mona O Rodriguez, Laura Schiraldi, Joanna J Smith, Kelsey F Sugrue, Lindsey J Suriano, Kaitlyn E Takach, Arielle M Vasquez, Ximena Velez, Elizabeth J Villafuerte, Laura T Vives, Victoria R Zellmer, Jeanette Hauke, Charles R Hauser, Karolyn Barker, Laurie Cannon, Perouza Parsamian, Samantha Parsons, Zachariah Wichman, Christopher W Bazinet, Diana E Johnson, Abubakarr Bangura, Jordan A Black, Victoria Chevee, Sarah A Einsteen, Sarah K Hilton, Max Kollmer, Rahul Nadendla, Joyce Stamm, Antoinette E Fafara-Thompson, Amber M Gygi, Emmy E Ogawa, Matt Van Camp, Zuzana Kocsisova, Judith L Leatherman, Cassie M Modahl, Michael R Rubin, Susana S Apiz-Saab, Suzette M Arias-Mejias, Carlos F Carrion-Ortiz, Patricia N Claudio-Vazquez, Debbie M Espada-Green, Marium Feliciano-Camacho, Karina M Gonzalez-Bonilla, Mariela Taboas-Arroyo, Dorianmarie Vargas-Franco, Raquel Montañez-Gonzalez, Joseph Perez-Otero, Myrielis Rivera-Burgos, Francisco J Rivera-Rosario, Heather L Eisler, Jackie Alexander, Samatha K Begley, Deana Gabbard, Robert J Allen, Wint Yan Aung, William D Barshop, Amanda Boozalis, Vanessa P Chu, Jeremy S Davis, Ryan N Duggal, Robert Franklin, Katherine Gavinski, Heran Gebreyesus, Henry Z Gong, Rachel A Greenstein, Averill D Guo, Casey Hanson, Kaitlin E Homa, Simon C Hsu, Yi Huang, Lucy Huo, Sarah Jacobs, Sasha Jia, Kyle L Jung, Sarah Wai-Chee Kong, Matthew R Kroll, Brandon M Lee, Paul F Lee, Kevin M Levine, Amy S Li, Chengyu Liu, Max Mian Liu, Adam P Lousararian, Peter B Lowery, Allyson P Mallya, Joseph E Marcus, Patrick C Ng, Hien P Nguyen, Ruchik Patel, Hashini Precht, Suchita Rastogi, Jonathan M Sarezky, Adam Schefkind, Michael B Schultz, Delia Shen, Tara Skorupa, Nicholas C Spies, Gabriel Stancu, Hiu Man Vivian Tsang, Alice L Turski, Rohit Venkat, Leah E Waldman, Kaidi Wang, Tracy Wang, Jeffrey W Wei, Dennis Y Wu, David D Xiong, Jack Yu, Karen Zhou, Gerard P McNeil, Robert W Fernandez, Patrick Gomez Menzies, Tingting Gu, Jeremy Buhler, Elaine R Mardis, Sarah C R Elgin
The discordance between genome size and the complexity of eukaryotes can partly be attributed to differences in repeat density. The Muller F element (∼5.2 Mb) is the smallest chromosome in Drosophila melanogaster , but it is substantially larger (>18.7 Mb) in D. ananassae To identify the major contributors to the expansion of the F element and to assess their impact, we improved the genome sequence and annotated the genes in a 1.4-Mb region of the D. ananassae F element, and a 1.7-Mb region from the D element for comparison...
August 7, 2017: G3: Genes—Genomes—Genetics
#19
JOURNAL ARTICLE
Judith E Epstein, Kristopher M Paolino, Thomas L Richie, Martha Sedegah, Alexandra Singer, Adam J Ruben, Sumana Chakravarty, April Stafford, Richard C Ruck, Abraham G Eappen, Tao Li, Peter F Billingsley, Anita Manoj, Joana C Silva, Kara Moser, Robin Nielsen, Donna Tosh, Susan Cicatelli, Harini Ganeshan, Jessica Case, Debbie Padilla, Silas Davidson, Lindsey Garver, Elizabeth Saverino, Tooba Murshedkar, Anusha Gunasekera, Patrick S Twomey, Sharina Reyes, James E Moon, Eric R James, Natasha Kc, Minglin Li, Esteban Abot, Arnel Belmonte, Kevin Hauns, Maria Belmonte, Jun Huang, Carlos Vasquez, Shon Remich, Mary Carrington, Yonas Abebe, Amy Tillman, Bradley Hickey, Jason Regules, Eileen Villasante, B Kim Lee Sim, Stephen L Hoffman
BACKGROUND: A radiation-attenuated Plasmodium falciparum (Pf) sporozoite (SPZ) malaria vaccine, PfSPZ Vaccine, protected 6 of 6 subjects (100%) against homologous Pf (same strain as in the vaccine) controlled human malaria infection (CHMI) 3 weeks after 5 doses administered intravenously. The next step was to assess protective efficacy against heterologous Pf (different from Pf in the vaccine), after fewer doses, and at 24 weeks. METHODS: The trial assessed tolerability, safety, immunogenicity, and protective efficacy of direct venous inoculation (DVI) of 3 or 5 doses of PfSPZ Vaccine in non-immune subjects...
January 12, 2017: JCI Insight
#20
JOURNAL ARTICLE
Paula Ruibal, Lisa Oestereich, Anja Lüdtke, Beate Becker-Ziaja, David M Wozniak, Romy Kerber, Miša Korva, Mar Cabeza-Cabrerizo, Joseph A Bore, Fara Raymond Koundouno, Sophie Duraffour, Romy Weller, Anja Thorenz, Eleonora Cimini, Domenico Viola, Chiara Agrati, Johanna Repits, Babak Afrough, Lauren A Cowley, Didier Ngabo, Julia Hinzmann, Marc Mertens, Inês Vitoriano, Christopher H Logue, Jan Peter Boettcher, Elisa Pallasch, Andreas Sachse, Amadou Bah, Katja Nitzsche, Eeva Kuisma, Janine Michel, Tobias Holm, Elsa-Gayle Zekeng, Isabel García-Dorival, Roman Wölfel, Kilian Stoecker, Erna Fleischmann, Thomas Strecker, Antonino Di Caro, Tatjana Avšič-Županc, Andreas Kurth, Silvia Meschi, Stephane Mély, Edmund Newman, Anne Bocquin, Zoltan Kis, Anne Kelterbaum, Peter Molkenthin, Fabrizio Carletti, Jasmine Portmann, Svenja Wolff, Concetta Castilletti, Gordian Schudt, Alexandra Fizet, Lisa J Ottowell, Eva Herker, Thomas Jacobs, Birte Kretschmer, Ettore Severi, Nobila Ouedraogo, Mar Lago, Anabel Negredo, Leticia Franco, Pedro Anda, Stefan Schmiedel, Benno Kreuels, Dominic Wichmann, Marylyn M Addo, Ansgar W Lohse, Hilde De Clerck, Carolina Nanclares, Sylvie Jonckheere, Michel Van Herp, Armand Sprecher, Gao Xiaojiang, Mary Carrington, Osvaldo Miranda, Carlos M Castro, Martin Gabriel, Patrick Drury, Pierre Formenty, Boubacar Diallo, Lamine Koivogui, N'Faly Magassouba, Miles W Carroll, Stephan Günther, César Muñoz-Fontela
Despite the magnitude of the Ebola virus disease (EVD) outbreak in West Africa, there is still a fundamental lack of knowledge about the pathophysiology of EVD. In particular, very little is known about human immune responses to Ebola virus. Here we evaluate the physiology of the human T cell immune response in EVD patients at the time of admission to the Ebola Treatment Center in Guinea, and longitudinally until discharge or death. Through the use of multiparametric flow cytometry established by the European Mobile Laboratory in the field, we identify an immune signature that is unique in EVD fatalities...
May 5, 2016: Nature
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