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Judith E Epstein, Kristopher M Paolino, Thomas L Richie, Martha Sedegah, Alexandra Singer, Adam J Ruben, Sumana Chakravarty, April Stafford, Richard C Ruck, Abraham G Eappen, Tao Li, Peter F Billingsley, Anita Manoj, Joana C Silva, Kara Moser, Robin Nielsen, Donna Tosh, Susan Cicatelli, Harini Ganeshan, Jessica Case, Debbie Padilla, Silas Davidson, Lindsey Garver, Elizabeth Saverino, Tooba Murshedkar, Anusha Gunasekera, Patrick S Twomey, Sharina Reyes, James E Moon, Eric R James, Natasha Kc, Minglin Li, Esteban Abot, Arnel Belmonte, Kevin Hauns, Maria Belmonte, Jun Huang, Carlos Vasquez, Shon Remich, Mary Carrington, Yonas Abebe, Amy Tillman, Bradley Hickey, Jason Regules, Eileen Villasante, B Kim Lee Sim, Stephen L Hoffman
BACKGROUND: A radiation-attenuated Plasmodium falciparum (Pf) sporozoite (SPZ) malaria vaccine, PfSPZ Vaccine, protected 6 of 6 subjects (100%) against homologous Pf (same strain as in the vaccine) controlled human malaria infection (CHMI) 3 weeks after 5 doses administered intravenously. The next step was to assess protective efficacy against heterologous Pf (different from Pf in the vaccine), after fewer doses, and at 24 weeks. METHODS: The trial assessed tolerability, safety, immunogenicity, and protective efficacy of direct venous inoculation (DVI) of 3 or 5 doses of PfSPZ Vaccine in non-immune subjects...
January 12, 2017: JCI Insight
Paul J McLaren, Cedric Coulonges, István Bartha, Tobias L Lenz, Aaron J Deutsch, Arman Bashirova, Susan Buchbinder, Mary N Carrington, Andrea Cossarizza, Judith Dalmau, Andrea De Luca, James J Goedert, Deepti Gurdasani, David W Haas, Joshua T Herbeck, Eric O Johnson, Gregory D Kirk, Olivier Lambotte, Ma Luo, Simon Mallal, Daniëlle van Manen, Javier Martinez-Picado, Laurence Meyer, José M Miro, James I Mullins, Niels Obel, Guido Poli, Manjinder S Sandhu, Hanneke Schuitemaker, Patrick R Shea, Ioannis Theodorou, Bruce D Walker, Amy C Weintrob, Cheryl A Winkler, Steven M Wolinsky, Soumya Raychaudhuri, David B Goldstein, Amalio Telenti, Paul I W de Bakker, Jean-François Zagury, Jacques Fellay
Previous genome-wide association studies (GWAS) of HIV-1-infected populations have been underpowered to detect common variants with moderate impact on disease outcome and have not assessed the phenotypic variance explained by genome-wide additive effects. By combining the majority of available genome-wide genotyping data in HIV-infected populations, we tested for association between ∼8 million variants and viral load (HIV RNA copies per milliliter of plasma) in 6,315 individuals of European ancestry. The strongest signal of association was observed in the HLA class I region that was fully explained by independent effects mapping to five variable amino acid positions in the peptide binding grooves of the HLA-B and HLA-A proteins...
November 24, 2015: Proceedings of the National Academy of Sciences of the United States of America
Paul J McLaren, Cédric Coulonges, Stephan Ripke, Leonard van den Berg, Susan Buchbinder, Mary Carrington, Andrea Cossarizza, Judith Dalmau, Steven G Deeks, Olivier Delaneau, Andrea De Luca, James J Goedert, David Haas, Joshua T Herbeck, Sekar Kathiresan, Gregory D Kirk, Olivier Lambotte, Ma Luo, Simon Mallal, Daniëlle van Manen, Javier Martinez-Picado, Laurence Meyer, José M Miro, James I Mullins, Niels Obel, Stephen J O'Brien, Florencia Pereyra, Francis A Plummer, Guido Poli, Ying Qi, Pierre Rucart, Manj S Sandhu, Patrick R Shea, Hanneke Schuitemaker, Ioannis Theodorou, Fredrik Vannberg, Jan Veldink, Bruce D Walker, Amy Weintrob, Cheryl A Winkler, Steven Wolinsky, Amalio Telenti, David B Goldstein, Paul I W de Bakker, Jean-François Zagury, Jacques Fellay
Multiple genome-wide association studies (GWAS) have been performed in HIV-1 infected individuals, identifying common genetic influences on viral control and disease course. Similarly, common genetic correlates of acquisition of HIV-1 after exposure have been interrogated using GWAS, although in generally small samples. Under the auspices of the International Collaboration for the Genomics of HIV, we have combined the genome-wide single nucleotide polymorphism (SNP) data collected by 25 cohorts, studies, or institutions on HIV-1 infected individuals and compared them to carefully matched population-level data sets (a list of all collaborators appears in Note S1 in Text S1)...
2013: PLoS Pathogens
Patrick R Shea, Kevin V Shianna, Mary Carrington, David B Goldstein
Since the discovery of HIV as the cause of AIDS, numerous insights have been gained from studies of its natural history and epidemiology. It has become clear that there are substantial interindividual differences in the risk of HIV acquisition and course of disease. Meanwhile, the field of human genetics has undergone a series of rapid transitions that have fundamentally altered the approach to studying HIV host genetics. We aim to describe the field as it has transitioned from the era of candidate-gene studies and the era of genome-wide association studies (GWAS) to its current state in the infancy of comprehensive sequencing...
2013: Annual Review of Medicine
Kimberly I Soderberg, Misty Sharp, Patrick R Carrington
No abstract text is available yet for this article.
November 2007: Archives of Dermatology
Camille C Ragin, Emanuela Taioli, Norma McFarlane-Anderson, Gordon Avery, Franklyn Bennett, Adelia Bovell-Benjamin, Angela Brown Thompson, Agatha Carrington, Lydia Campbell-Everett, Jacqueline Ford, Anselm Hennis, Maria Jackson, Sandra Lake, M Cristina Leske, Carol Magai, Barbara Nemesure, Alfred Neugut, Folakemi Odedina, Michael Okobia, Alan Patrick, Wallis Best Plummer, R Renee Reams, Robin Roberts, Sharaneen Scott-Hastings, Sangita Sharma, Victor Wheeler, Suh-Yuh Wu, Clareann Bunker
This is a short summary of a meeting of the "African-Caribbean Cancer Consortium", jointly organized by the University of Pittsburgh, Department of Epidemiology and the University of Pittsburgh Cancer Institute, held in Montego Bay, Jamaica as a satellite meeting at the Caribbean Health Research Council, 52nd Annual Council and Scientific meeting on May 4, 2007.
September 24, 2007: Infectious Agents and Cancer
Patrick R Carrington, Thomas D Horn
We report the case of an 84-year-old white male who underwent vermilionectomy for removal of a tumor, which proved to be squamous cell carcinoma. Chelitis glandularis related to marked actinic damage was noted at a subsequent visit. The presence of chelitis glandularis should be investigated for the presence of neoplasia, immunosuppression, or inflammatory diseases related to extremely poor oral hygiene.
February 2006: Journal of the American Academy of Dermatology
Edward L Lain, Patrick R Carrington
No abstract text is available yet for this article.
November 2005: Archives of Dermatology
M Carrington Reid, Mary E Tinetti, Patrick G O'Connor, Thomas R Kosten, John Concato
We determined levels of agreement and concordance between five alcohol measures among older veterans from a VA primary care clinic (N=303) and community-dwelling Medicare beneficiaries (N=511). The individuals recruited for the study had not been previously identified for alcohol use. Quantity-frequency questions, a binge drinking question, the Alcohol Use Disorders Identification Test, CAGE, and questions on lifetime consumption were administered to all current drinkers. To assess agreement between the measures, we conducted pairwise comparisons (eg, QF vs...
May 2003: American Journal on Addictions
Patrick R Carrington
BACKGROUND: "Breaks" in barrier precautions are a definite abrogating influence on the effectiveness of "universal precautions." Dermatologists and dermatologic surgeons are exposed to significant infectious agents on a daily basis, especially due to the high number of minor surgical procedures performed. Backsplash, spray, and eye splash of bodily fluids during these procedures place the surgeon at a high risk of contamination/infection via the conjunctival membranes. The surgical looking glass is a simple utility based on inexpensive equipment already in place in the physician's office which protects the eyes and face during infiltrative anesthesia or incision of cysts and other lesions...
April 2002: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
R A Ponce, S M Bartell, E Y Wong, D LaFlamme, C Carrington, R C Lee, D L Patrick, E M Faustman, M Bolger
Risks associated with toxicants in food are often controlled by exposure reduction. When exposure recommendations are developed for foods with both harmful and beneficial qualities, however, they must balance the associated risks and benefits to maximize public health. Although quantitative methods are commonly used to evaluate health risks, such methods have not been generally applied to evaluating the health benefits associated with environmental exposures. A quantitative method for risk-benefit analysis is presented that allows for consideration of diverse health endpoints that differ in their impact (i...
August 2000: Risk Analysis: An Official Publication of the Society for Risk Analysis
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