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https://www.readbyqxmd.com/read/26730844/prevalence-incidence-risk-factors-and-treatment-of-atrial-fibrillation-in-australia-the-australian-diabetes-obesity-and-lifestyle-ausdiab-longitudinal-population-cohort-study
#1
Ibrahima Diouf, Dianna J Magliano, Melinda J Carrington, Simon Stewart, Jonathan E Shaw
OBJECTIVE: We sought to describe the prevalence, incidence, risk factors and treatment (according to stroke risk) of atrial fibrillation (AF) in the national, population-based Australian Diabetes, Obesity and Lifestyle (AusDiab) study cohort. METHODS: ECG data were available from 8273/11,247 participants of AusDiab study in 1999/2000 and from 5422 participants in 2004/2005. Minnesota coding was used to identify prevalent and incident cases of AF. RESULTS: 90 prevalent cases of AF (14...
February 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/23636221/relation-of-hla-class-i-and-ii-supertypes-with-spontaneous-clearance-of-hepatitis-c-virus
#2
M H Kuniholm, K Anastos, A Kovacs, X Gao, D Marti, A Sette, R M Greenblatt, M Peters, M H Cohen, H Minkoff, S J Gange, C L Thio, M A Young, X Xue, M Carrington, H D Strickler
Human leukocyte antigen (HLA) genotype has been associated with the probability of spontaneous clearance of hepatitis C virus (HCV). However, no prior studies have examined whether this relationship may be further characterized by grouping HLA alleles according to their supertypes, defined by their binding capacities. There is debate regarding the most appropriate method to define supertypes. Therefore, previously reported HLA supertypes (46 class I and 25 class II) were assessed for their relation with HCV clearance in a population of 758 HCV-seropositive women...
July 2013: Genes and Immunity
https://www.readbyqxmd.com/read/22795400/redefining-the-ecg-in-urban-south-africans-electrocardiographic-findings-in-heart-disease-free-africans
#3
Karen Sliwa, Geraldine A Lee, Melinda J Carrington, Pro Obel, Andrzej Okreglicki, Simon Stewart
BACKGROUND: The 12-lead electrocardiogram (ECG) represents an important diagnostic tool for detecting heart disease, but the "normal" ECG in those of African descent has yet to be definitively described. METHODS: We systematically analysed 12-lead ECGs from 387 urban South Africans determined to be heart disease free (using the Minnesota code) following advanced cardiologic assessment, including echocardiography, at the Baragwanath Hospital in Soweto, South Africa...
September 1, 2013: International Journal of Cardiology
https://www.readbyqxmd.com/read/20169624/specific-human-leukocyte-antigen-class-i-and-ii-alleles-associated-with-hepatitis-c-virus-viremia
#4
MULTICENTER STUDY
Mark H Kuniholm, Andrea Kovacs, Xiaojiang Gao, Xiaonan Xue, Darlene Marti, Chloe L Thio, Marion G Peters, Norah A Terrault, Ruth M Greenblatt, James J Goedert, Mardge H Cohen, Howard Minkoff, Stephen J Gange, Kathryn Anastos, Melissa Fazzari, Tiffany G Harris, Mary A Young, Howard D Strickler, Mary Carrington
UNLABELLED: Studies of human leukocyte antigen (HLA) alleles and their relation with hepatitis C virus (HCV) viremia have had conflicting results. However, these studies have varied in size and methods, and few large studies assessed HLA class I alleles. Only one study conducted high-resolution class I genotyping. The current investigation therefore involved high-resolution HLA class I and II genotyping of a large multiracial cohort of U.S. women with a high prevalence of HCV and HIV...
May 2010: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/15452550/phase-i-dose-escalation-trial-of-irinotecan-with-continuous-infusion-5-fu-first-line-in-metastatic-colorectal-cancer
#5
M P Saunders, M Hogg, B Carrington, A-M Sjursen, J Allen, J Beech, R Swindell, J W Valle
This single-centre phase I trial was designed to determine the maximum tolerated dose of irinotecan and the recommended dose to use in combination with a fixed dose of 5-fluorouracil (5-FU) administered as a protracted venous infusion, for the first-line treatment of metastatic colorectal cancer (CRC). Tolerability and efficacy were secondary end points. In all, 22 patients, median age 57 years, were treated with escalating, weekly doses of irinotecan (50, 75, 100 and 85 mg m(-2)) in combination with 250 mg m(-2) 5-FU administered as a continuous infusion...
October 18, 2004: British Journal of Cancer
https://www.readbyqxmd.com/read/10483804/the-effects-of-athletic-training-and-muscle-contractile-character-on-the-pressor-response-to-isometric-exercise-of-the-human-triceps-surae
#6
C A Carrington, W Fisher, M J White
In this study, the influence of athletic training status and the contractile character of the active muscle on the magnitude of the pressor response (PR) to voluntary and electrically evoked isometric plantar flexion was investigated. Subjects were 10 sprint-trained athletes (sprint) (100-m, 200-m and 400-m) [mean (SD) age, 21 (2) years], 14 endurance trained athletes (distance) [22 (2) years] and 8 untrained men (control) [23 (3) years]. Twitch time to peak tension (TPT) in the sprint group [108 (7) ms] was significantly less (P<0...
September 1999: European Journal of Applied Physiology and Occupational Physiology
https://www.readbyqxmd.com/read/9628015/identification-and-characterization-of-a-locus-rtm1-that-restricts-long-distance-movement-of-tobacco-etch-virus-in-arabidopsis-thaliana
#7
COMPARATIVE STUDY
S K Mahajan, S T Chisholm, S A Whitham, J C Carrington
Screens of Arabidopsis thaliana for susceptibility to tobacco etch virus (TEV) revealed that each of 10 ecotypes were able to support genome replication and cell-to-cell movement in inoculated leaves. However, only four ecotypes, including C24 and La-er, supported complete infections in which TEV was able to replicate and move from cell to cell and long distances through the vasculature. The rates of cell-to-cell movement of a reporter-tagged TEV strain (TEV-GUS) in inoculated leaves of C24 and Columbia (Col-3) were similar, and infection foci continued to expand in both ecotypes through 10 days post-inoculation...
April 1998: Plant Journal: for Cell and Molecular Biology
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