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https://www.readbyqxmd.com/read/29054924/pharmacotherapy-for-patients-with-obesity
#1
REVIEW
Kishore M Gadde, John W Apolzan, Hans-Rudolf Berthoud
BACKGROUND: Although pharmacotherapy is not the cornerstone of obesity treatment, it is a valuable tool that could be considered for patients who have not had adequate benefit from lifestyle interventions or who have difficulty maintaining initial weight loss over longer periods. CONTENT: This review focuses on the role of antiobesity drugs, the mechanisms by which the drugs work, potential pharmacological targets in the neural control of food intake and regulation of body weight, the history of antiobesity drugs, a summary of efficacy and safety data from clinical trials, and the clinical application of pharmacotherapy...
October 20, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29053709/changes-in-utilization-and-peri-operative-outcomes-of-bariatric-surgery-in-large-u-s-hospital-database-2011-2014
#2
Lu Zhang, John Scott, Lu Shi, Khoa Truong, Qingwei Hu, Joseph A Ewing, Liwei Chen
BACKGROUND: With the epidemic of morbid obesity, bariatric surgery has been accepted as one of the most effective treatments of obesity. OBJECTIVE: To investigate recent changes in the utilization of bariatric surgery, patients and hospital characteristics, and in-hospital complications in a nationwide hospital database in the United States. SETTING: This is a secondary data analysis of the Premier Perspective database. METHODS: ICD-9 codes were used to identify bariatric surgeries performed between 2011 and 2014...
2017: PloS One
https://www.readbyqxmd.com/read/29053575/the-impact-of-a-weight-loss-intervention-on-diet-quality-and-eating-behaviours-in-people-with-obesity-and-copd
#3
Rebecca F McLoughlin, Vanessa M McDonald, Peter G Gibson, Hayley A Scott, Michael J Hensley, Lesley MacDonald-Wicks, Lisa G Wood
There is a paucity of evidence to guide clinicians about appropriate management strategies for people with obesity and Chronic Obstructive Pulmonary Disease (COPD). We have recently published results from the first weight loss intervention in adults (>18 years) with obesity (body mass index; BMI ≥ 30 kg/m²) and COPD, using a low-calorie diet coupled with a partial meal replacement plan and resistance exercise training, which resulted in a 6.4% reduction in weight while maintaining skeletal muscle mass and improving health status...
October 20, 2017: Nutrients
https://www.readbyqxmd.com/read/29052345/views-of-diverse-primary-care-patients-on-the-roles-of-healthcare-providers-and-staff-and-the-influence-of-other-variables-in-their-weight-management
#4
C M Tucker, J L Williams, G M Wippold, L A Bilello, T A Morrissette, A J Good, N R Shah, N E Rowland
The prevalence of overweight/obesity is disproportionately higher among racial/ethnic minority and low-income patients. The purpose of this study was to survey racially diverse, low-income patients regarding their experiences with and desires regarding their providers' involvement in weight management. Adult patients (N = 529), including mostly African American (42.7%), White (44.6%) and low-income (55.5% with incomes <$30 000) patients from 7 Patient-Centered Medical Homes voluntarily completed a brief anonymous survey while waiting to see their providers...
October 20, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/29052152/a-new-understanding-of-quality-of-life-in-children-and-adolescents-with-obesity-contribution-of-the-self-determination-theory
#5
REVIEW
Marie Buttitta, Amélie Rousseau, Alain Guerrien
PURPOSE OF REVIEW: Preservation of Quality of Life (QOL) is now a major determinant of obesity management, but little is known about variables predicting QOL. Identifying these predicting variables of QOL would provide further understanding of the QOL concept and help draw clinical implications. The Self-determination Theory (SDT) is a promising understanding perspective of the QOL. RECENT FINDINGS: The SDT postulates that well-being and motivation are determined by the satisfaction of three needs: autonomy, competence, and relatedness...
October 19, 2017: Current Obesity Reports
https://www.readbyqxmd.com/read/29051554/recombinant-incretin-secreting-microbe-improves-metabolic-dysfunction-in-high-fat-diet-fed-rodents
#6
Paul M Ryan, Elaine Patterson, Robert M Kent, Helena Stack, Paula M O'Connor, Kiera Murphy, Veronica L Peterson, Rupasri Mandal, David S Wishart, Timothy G Dinan, John F Cryan, Randy J Seeley, Catherine Stanton, R Paul Ross
The gut hormone glucagon-like peptide (GLP)-1 and its analogues represent a new generation of anti-diabetic drugs, which have also demonstrated propensity to modulate host lipid metabolism. Despite this, drugs of this nature are currently limited to intramuscular administration routes due to intestinal degradation. The aim of this study was to design a recombinant microbial delivery vector for a GLP-1 analogue and assess the efficacy of the therapeutic in improving host glucose, lipid and cholesterol metabolism in diet induced obese rodents...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29050221/pdgfra-hsd17b4-and-hmgb2-are-potential-therapeutic-targets-in-polycystic-ovarian-syndrome-and-breast-cancer
#7
Huiyu Xu, Yong Han, Jiaying Lou, Hongxian Zhang, Yue Zhao, Balázs Győrffy, Rong Li
To explore the key genes associated with both PCOS and breast cancer, we overlapped the synchronously differently expressed genes in two obese insulin-resistant GEO datasets in muscle tissue and genes exert essential roles in breast cancer prognosis together base on the following reasons: (1) Androgens excess is believed to contribute to the onset of both PCOS and breast cancer. (2) PCOS is usually complicated with metabolic symptoms, such as obesity and insulin-resistance. (3) Muscle is the main place where energy metabolism and material metabolism take place...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049270/adipokine-profile-in-patients-with-type-2-diabetes-depends-on-degree-of-obesity
#8
Joanna Kocot, Piotr Dziemidok, Małgorzata Kiełczykowska, Anna Hordyjewska, Grzegorz Szcześniak, Irena Musik
BACKGROUND The fast pace of life, promoting fast food consumption and low physical activity, has resulted in obesity and/or diabetes as being serious social problems. The aim of the present study was to evaluate concentrations of selected adipokines (leptin, adiponectin, resistin, and visfatin) and to assess the leptin/adiponectin ratio in plasma of type 2 diabetes (T2D) patients in relation to degree of obesity. MATERIAL AND METHODS The study comprised 92 T2D subjects divided into 4 groups according to BMI value - I (normal body weight), II (overweight), III (obesity), and IV (severe obesity) - and 20 healthy volunteers (control group)...
October 19, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29049180/the-effect-of-care-intervention-for-obese-patients-with-type-ii-diabetes
#9
Xuelian Jiang, Xiyun Fan, Rui Wu, Fengqin Geng, Chenping Hu
The incidence of type II diabetes mellitus (T2DM) is increasing worldwide and affecting the quality of people's life. This study was designed to evaluate the effect of care intervention on body weight and glycemic parameters in obese T2DM patients.One hundred twenty-six obese T2DM cases were randomly divided into 2 groups. Patients in control group received conventional care, while patients in the intervention group received dietary, exercise, and psychology interventions on the basis of conventional care. Twelve months follow-up was performed to compare the changes of body weight and glycemic parameters in the 2 groups...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049120/a-contemporary-medicolegal-analysis-of-outpatient-medication-management-in-chronic-pain
#10
Christopher R Abrecht, Ethan Y Brovman, Penny Greenberg, Ellen Song, James P Rathmell, Richard D Urman
BACKGROUND: Opioids are frequently used in chronic pain management but are associated with significant morbidity and mortality in some patient populations. An important avenue for identifying complications-including serious or rare complications-is the study of closed malpractice claims. The present study is intended to complement the existing closed claims literature by drawing on claims from a more recent timeframe through a partnership with a large malpractice carrier, the Controlled Risk Insurance Company (CRICO)...
November 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29049041/the-impact-of-lifestyle-intervention-on-atrial-fibrillation
#11
Kathryn L Hong, Benedict M Glover
PURPOSE OF REVIEW: Atrial fibrillation is the most common sustained cardiac arrhythmia, attributable to several factors that may be amenable through lifestyle modification. There is emerging evidence to suggest that the successful management of several cardiovascular risk factors [obesity, hypertension (HTN), diabetes mellitus, and obstructive sleep apnea (OSA)] can lead to fewer complications and atrial fibrillation prevention. However, the long-term sustainability and reproducibility of these effects have yet to be explored in larger studies...
October 18, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29049021/do-black-women-s-religious-beliefs-about-body-image-influence-their-confidence-in-their-ability-to-lose-weight
#12
Alexandria G Bauer, Jannette Berkley-Patton, Carole Bowe-Thompson, Therese Ruhland-Petty, Marcie Berman, Sheila Lister, Kelsey Christensen
INTRODUCTION: Black women are disproportionately burdened by obesity but maintain body satisfaction and strong religious commitment. Although faith-based weight-loss interventions have been effective at promoting weight loss among blacks, little is known about how body image and religious views contribute to weight-related beliefs among religious black women. The purpose of this study was to examine whether demographic and health history factors, religious involvement, and beliefs about body image could explain motivation and confidence to lose weight among a church-affiliated sample of black women...
October 19, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29048949/discovering-pediatric-asthma-phenotypes-based-on-response-to-controller-medication-using-machine-learning
#13
Mindy K Ross, Jinsung Yoon, Auke van der Schaar, Mihaela van der Schaar
RATIONALE: Pediatric asthma has variable underlying inflammation and symptom control. Approaches to address this heterogeneity such as clustering methods to find phenotypes and predicting outcomes have been investigated. However, clustering based upon the relationship between treatment and clinical outcome has not been performed. Also, machine learning approaches for long-term outcome prediction in pediatric asthma have not been studied in depth. OBJECTIVES: Our objectives were to use our novel machine learning algorithm, Predictor Pursuit (PP) to discover pediatric asthma phenotypes based on treatment response to different asthma controller medications, to predict outcomes of children with asthma over time, and to identify the most indicative features of asthma control for the discovered pediatric phenotypes...
October 19, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29048709/comparison-of-percutaneous-dilatational-tracheostomy-guided-by-ultrasound-and-bronchoscopy-in-critically-ill-obese-patients
#14
Jieqiong Song, Lizhen Xuan, Wei Wu, Duming Zhu, Yijun Zheng
OBJECTIVES: This study aimed to compare the efficacy and safety of percutaneous dilatational tracheostomy (PDT) with ultrasound (US) or bronchoscopic guidance for critically ill patients, notably obese patients. METHODS: This work was a retrospective study. The study included mechanically ventilated patients who underwent PDT from August 2013 to July 2015 in the Department of Critical Care Medicine of Zhongshan Hospital. The patients were classified according to the different guidance methods during tracheotomy and their body mass index in the following 4 groups: normal bronchoscopy group, normal US group, obese bronchoscopy group, and obese US group...
October 19, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29048572/ventriculoscopic-surgery-for-cystic-retrochiasmatic-craniopharyngiomas-indications-surgical-technique-and-short-term-patient-outcomes
#15
Todd C Hollon, Luis E Savastano, David Altshuler, Ariel L Barkan, Stephen E Sullivan
BACKGROUND: Attempted gross-total resection for the management of cystic retrochiasmatic craniopharyngiomas can cause severe hypothalamic dysfunction and decrease overall survival. Ventriculoscopic surgery is a minimally invasive alternative; however, potential indications and technique have not been well defined. OBJECTIVE: To present our indications and technique for the ventriculoscopic treatment of cystic retrochiasmatic craniopharyngiomas. METHODS: We evaluated all patients with retrochiasmatic craniopharyngiomas for ventriculoscopic surgery...
October 18, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29048553/are-preschoolers-meeting-the-mark-comparing-the-dietary-activity-and-sleep-behaviors-of-preschoolers-with-obesity-to-national-recommendations
#16
Cathleen Odar Stough, Mary Beth McCullough, Shannon L Robson, Christopher Bolling, Stephanie Spear Filigno, Jessica C Kichler, Cynthia Zion, Lisa M Clifford, Stacey L Simon, Richard F Ittenbach, Lori J Stark
Objective: National health organizations and expert committees have issued recommendations for health behaviors related to obesity risk. Behavioral and family-based weight management interventions for preschoolers often target improving adherence to these recommendations, but it is unknown how the health behaviors of preschoolers with obesity enrolled in weight control treatments (WCTs) compare with these guidelines. In this study, the dietary intake, activity, and sleep behaviors of preschoolers with obesity enrolled in a family-based behavioral WCT are described and compared with national health behavior recommendations...
October 17, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29046951/time-trends-in-colorectal-cancer-early-postoperative-mortality-a-french-25-year-population-based-study
#17
Sylvain Manfredi, Valérie Jooste, Caroline Gay, Jean Faivre, Antoine Drouillard, Anne-Marie Bouvier
BACKGROUND: Postoperative mortality after resection of colorectal cancer is an important issue. The aim of this study was to assess early postoperative mortality in a well-defined French population. METHODS: Data on 30- and 90-day postoperative mortality after resection for colorectal cancer were extracted from the digestive cancer registry of Burgundy. Time trends of postoperative mortality between 1989 and 2013 were described for the large population. Case-control studies (death within 30 or 90 days = cases, alive at 90 days = controls) focused on the association between postoperative mortality and surgical approach, obesity and other comorbidities over the last [2010-2013] period, using conditional logistic regressions...
October 19, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29044720/observational-comparative-effectiveness-of-pharmaceutical-treatments-for-obesity-within-the-veterans-health-administration
#18
Ted R Grabarczyk
STUDY OBJECTIVE: To compare the effectiveness of weight-management medications used to assist with weight loss in real-world clinical practice in the Veterans Health Administration (VHA). DESIGN: Retrospective, multicenter, observational cohort study. DATA SOURCE: National VA Corporate Data Warehouse. PATIENTS: A total of 66,035 VA patients aged 18 years or older with a body mass index of 25 kg/m(2) or greater who had an initial fill for a study medication (orlistat [6153 patients], phentermine [304 patients], lorcaserin [298 patients], or phentermine-topiramate extended release [233 patients]) or participation in the VA's MOVE! weight management program with at least three total visits in a clinic coded as a MOVE clinic in the subsequent 24 weeks (59,047 patients) between January 1, 2012 and July 1, 2016...
October 17, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/29043480/body-mass-index-bmi-postoperative-appearance-satisfaction-and-sexual-function-in-breast-cancer-survivorship
#19
K E Rojas, N Matthews, C Raker, M A Clark, M Onstad, A Stuckey, J Gass
PURPOSE: We sought to explore the correlation between BMI and postoperative sexual function, body image, and breast-specific sensuality before and after breast cancer surgery. METHODS: A cross-sectional survey of patients at least 1 year from surgery employed the Female Sexual Function Index (FSFI) and investigator-generated questions. Patients who underwent lumpectomy (L), mastectomy (M), and mastectomy with reconstruction (MR) were compared across three BMI groups: normal weight, overweight, and obese...
October 17, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29042804/weight-loss-medications-in-canada-a-new-frontier-or-a-repeat-of-past-mistakes
#20
Sean Wharton, Jasmine Lee, Rebecca Ag Christensen
Current methods for the treatment of excess weight can involve healthy behavior changes, pharmacotherapy, and surgical interventions. Many individuals are able to lose some degree of weight through behavioral changes; however, they are often unable to maintain their weight loss long-term. This is in part due to physiological processes that cannot be addressed through behavioral changes alone. Bariatric surgery, which is the most successful treatment for excess weight to date, does result in physiological changes that can help with weight loss and weight maintenance...
2017: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
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