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https://www.readbyqxmd.com/read/29307306/viruses-bacteria-and-parasites-oh-my-a-resurgence-of-interest-in-microbial-based-therapy-for-cancer
#1
EDITORIAL
Andrew Zloza
As infections and cancer are two of the most common maladies affecting human beings, a concerted effort is needed to better understand their potential interactions and to further explore their use in microbial-based cancer treatments. Studies focusing on the interaction between pathogens and cancer began over 4000 years ago, but therapeutic application of pathogens has often been bypassed as other cancer therapies have gained wider interest. To many, the field of microbial-based cancer treatment may feel antiquated and already sufficiently explored...
January 8, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29278684/isolation-of-human-lymphocytes-with-high-yield-and-viability-from-the-gastrointestinal-and-female-reproductive-tract-of-a-humanized-drag-mouse
#2
Atef Allam, Kristina K Peachman, Rodrigo Aguilera-Olvera, Sofia Casares, Mangala Rao
The mucosal tissues of the gut and female reproductive tract (FRT) are susceptible to pathogen infections including bacteria, viruses, and parasites, and are also the targets for immune disorders such as Crohn's disease, inflammatory bowel disease (IBD), and many types of cancers. However, the role of the mucosal immune cells to control these diseases is largely unknown. The limited availability of human mucosal biopsy tissue and the low number of cells that can be isolated from these tissues hampers the characterization of the phenotype and function of human mucosal immune cell subsets...
December 23, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/29247998/the-aim2-inflammasome-sensor-of-pathogens-and-cellular-perturbations
#3
REVIEW
Jérôme Lugrin, Fabio Martinon
Recognition of pathogens and altered self must be efficient and highly specific to orchestrate appropriate responses while limiting excessive inflammation and autoimmune reaction to normal self. AIM2 is a member of innate immune sensors that detects the presence of DNA, arguably the most conserved molecules in living organisms. However, AIM2 achieves specificity by detecting altered or mislocalized DNA molecules. It can detect damaged DNA, and the aberrant presence of DNA within the cytosolic compartment such as genomic DNA released into the cytosol upon loss of nuclear envelope integrity...
January 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29157671/infectious-agents-in-childhood-leukemia
#4
REVIEW
José Arellano-Galindo, Alberto Parra Barrera, Elva Jiménez-Hernández, Sergio Zavala-Vega, Guillermina Campos-Valdéz, Juan Xicohtencatl-Cortes, Sara A Ochoa, Ariadnna Cruz-Córdova, María Del Pilar Crisóstomo-Vázquez, Juan Carlos Fernández-Macías, Juan Manuel Mejía-Aranguré
Acute leukemia is the most common pediatric cancer, representing one-third of all cancers that occurs in under 15 year olds, with a varied incidence worldwide. Although a number of advances have increased the knowledge of leukemia pathophysiology, its etiology remains less well understood. The role of infectious agents, such as viruses, bacteria, or parasites, in the pathogenesis of leukemia has been discussed. To date, several cellular mechanisms involving infectious agents have been proposed to cause leukemia following infections...
May 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28430160/subverting-host-cell-p21-activated-kinase-a-case-of-convergent-evolution-across-pathogens
#5
REVIEW
Simona John Von Freyend, Terry Kwok-Schuelein, Hans J Netter, Gholamreza Haqshenas, Jean-Philippe Semblat, Christian Doerig
Intracellular pathogens have evolved a wide range of strategies to not only escape from the immune systems of their hosts, but also to directly exploit a variety of host factors to facilitate the infection process. One such strategy is to subvert host cell signalling pathways to the advantage of the pathogen. Recent research has highlighted that the human serine/threonine kinase PAK, or p21-activated kinase, is a central component of host-pathogen interactions in many infection systems involving viruses, bacteria, and eukaryotic pathogens...
April 21, 2017: Pathogens
https://www.readbyqxmd.com/read/28188605/-cancer-and-mycoses-and-literature-review
#6
REVIEW
M Develoux
Various infectious agents are classical risk factors for cancer including bacteria, viruses and parasites. There is less evidence concerning the implication of fungal infection in carcinogenesis. The role of chronic Candida infection in the development of squamous cell carcinoma has been suspected for years. Candida sp are more prevalent in potentially malignant disorder and cancer of the oral mucosa. Other epidemiological evidence of a link between Candida infection and cancer is what is observed in patients with Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED)...
February 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28042926/the-potential-impact-of-gut-microbiota-on-your-health-current-status-and-future-challenges
#7
REVIEW
Stitaya Sirisinha
Our health and probably also our behaviors and mood depend not only on what we eat or what we do (lifestyle behaviors), but also on what we host. It is well established for decades that all vertebrates including humans are colonized by a wide array of bacteria, fungi, eukaryotic parasites and viruses, and that, at steady state (homeostasis), this community of microbes establishes a friendly mutual relationship with the host. The term microbiota was originally meant to represent an ecological community of commensals and potentially pathogenic microbes that live within our bodies, but it is now used interchangeably with the term microbiome which was initially meant to represent a collective genome of the microbiota...
December 2016: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/27956028/parasite-infection-carcinogenesis-and-human-malignancy
#8
REVIEW
Hoang van Tong, Paul J Brindley, Christian G Meyer, Thirumalaisamy P Velavan
Cancer may be induced by many environmental and physiological conditions. Infections with viruses, bacteria and parasites have been recognized for years to be associated with human carcinogenicity. Here we review current concepts of carcinogenicity and its associations with parasitic infections. The helminth diseases schistosomiasis, opisthorchiasis, and clonorchiasis are highly carcinogenic while the protozoan Trypanosoma cruzi, the causing agent of Chagas disease, has a dual role in the development of cancer, including both carcinogenic and anticancer properties...
February 2017: EBioMedicine
https://www.readbyqxmd.com/read/27920891/working-principle-and-application-of-magnetic-separation-for-biomedical-diagnostic-at-high-and-low-field-gradients
#9
REVIEW
Sim Siong Leong, Swee Pin Yeap, JitKang Lim
Magnetic separation is a versatile technique used in sample preparation for diagnostic purpose. For such application, an external magnetic field is applied to drive the separation of target entity (e.g. bacteria, viruses, parasites and cancer cells) from a complex raw sample in order to ease the subsequent task(s) for disease diagnosis. This separation process not only can be achieved via the utilization of high magnetic field gradient, but also, in most cases, low magnetic field gradient with magnitude less than 100 T m(-1) is equally feasible...
December 6, 2016: Interface Focus
https://www.readbyqxmd.com/read/27822455/burden-of-cancers-attributable-to-infectious-agents-in-nigeria-2012-2014
#10
Michael Odutola, Elima E Jedy-Agba, Eileen O Dareng, Emmanuel Aja Oga, Festus Igbinoba, Theresa Otu, Emmanuel Ezeome, Ramatu Hassan, Clement A Adebamowo
INTRODUCTION: Infections by certain viruses, bacteria, and parasites have been identified as risk factors for some cancers. In Nigeria, like many other developing countries, infections remain a leading cause of morbidity and mortality. While there are data on the incidence of different cancers in Nigeria, there has been no study of cancers attributable to infections. This study was carried out to determine the burden of cancers attributable to infections using data from two population-based cancer registries (PBCRs) in Nigeria...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27785601/the-human-immune-system-s-response-to-carcinogenic-and-other-infectious-agents-transmitted-by-mosquito-vectors
#11
REVIEW
Olle Johansson, Martin Ward
It has been hypothesised that mosquitoes [Diptera: Culicidae] may play more of a role in certain cancers than is currently appreciated. Research links 33 infectious agents to cancer, 27 of which have a presence in mosquitoes, and that, in addition, mosquito saliva downregulates the immune system. The objective of this paper is to review the literature on the immune system and cancer-causing infectious agents, particularly those present in mosquitoes, with a view to establishing whether such infectious agents can, in the long run, defeat the immune system or be defeated by it...
January 2017: Parasitology Research
https://www.readbyqxmd.com/read/27784307/mammalian-microrna-an-important-modulator-of-host-pathogen-interactions-in-human-viral-infections
#12
REVIEW
Chet Raj Ojha, Myosotys Rodriguez, Seth M Dever, Rita Mukhopadhyay, Nazira El-Hage
MicroRNAs (miRNAs), which are small non-coding RNAs expressed by almost all metazoans, have key roles in the regulation of cell differentiation, organism development and gene expression. Thousands of miRNAs regulating approximately 60 % of the total human genome have been identified. They regulate genetic expression either by direct cleavage or by translational repression of the target mRNAs recognized through partial complementary base pairing. The active and functional unit of miRNA is its complex with Argonaute proteins known as the microRNA-induced silencing complex (miRISC)...
October 26, 2016: Journal of Biomedical Science
https://www.readbyqxmd.com/read/27758751/-parasites-and-cancer-is-there-a-causal-link
#13
Kevin Cheeseman, Gabriela Certad, Jonathan B Weitzman
Over 20 % of cancers have infectious origins, including well-known examples of microbes such as viruses (HPV, EBV) and bacteria (H. pylori). The contribution of intracellular eukaryotic parasites to cancer etiology is largely unexplored. Epidemiological and clinical reports indicate that eukaryotic protozoan, such as intracellular apicomplexan that cause diseases of medical or economic importance, can be linked to various cancers: Theileria and Cryptosporidium induce host cell transformation while Plasmodium was linked epidemiologically to the "African lymphoma belt" over fifty years ago...
October 2016: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/27741173/gut-microbiome-and-gastrointestinal-cancer-les-liaisons-dangereuses
#14
Nurdan Tözün, Eser Vardareli
Gastrointestinal (GI) cancers are the leading cause of mortality worldwide. These cancers are the end result of a complex interplay between gene and environment. Bacteria, parasites, and viruses have been implicated in some cancers. Recent data have put at focus the gut microbiome as the key player firing tumorigenesis. Experimental and human studies have provided evidence on the role of microbiota in cancer development. Although subject to changes in different settings such as antibiotic treatment, diet or lifestyle, our microbiome is quite stable and is capable of increasing susceptibility to cancer or decrease and halt its progression...
November 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27594291/microbiota-in-health-and-in-sickness-from-birth-to-death
#15
REVIEW
Salih Kuk, Yunus Uyar, Serkan Karaca, Süleyman Yazar
Microorganisms colonize tissues and organs such as the skin and gastrointestinal, respiratory, and genitourinary systems. These microorganisms are generally called as "human microbiota". Human microbiota mostly consists of commensal microorganisms. The commensal microorganisms located on and in the human body are bacteria, fungi, viruses, archaea, and parasites. The microbiota genome is 100 times bigger in size than the human genome. Although the human genome is stationary, microbial genome has a compatible flexible variability during human life...
June 2016: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/27503270/composite-membranes-of-recombinant-silkworm-antimicrobial-peptide-and-poly-l-lactic-acid-plla-for-biomedical-application
#16
Zhi Li, Xuan Liu, Yi Li, Xiqian Lan, Polly Hangmei Leung, Jiashen Li, Gang Li, Maobin Xie, Yanxia Han, Xiaofen Lin
Antimicrobial peptides, produced by innate immune system of hosts in response to invading pathogens, are capable of fighting against a spectrum of bacteria, viruses, fungi, parasites and cancer cells. Here, a recombinant silkworm AMP Bmattacin2 from heterologous expression is studied, indicating a broad spectrum of antibacterial activity and showing selective killing ability towards skin and colon cancer cells over their normal cell counterparts. For the purpose of biomedical application, the electrospinning fabrication technique is employed to load Bmattacin2 into PLLA nanofibrous membrane...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27499495/hostile-takeover-manipulation-of-hif-1-signaling-in-pathogen-associated-cancers-review
#17
REVIEW
Caixia Zhu, Qing Zhu, Chong Wang, Liming Zhang, Fang Wei, Qiliang Cai
Hypoxia-inducible factor (HIF)-1 is a central regulator in the adaptation process of cell response to hypoxia (low oxygen). Emerging evidence has demonstrated that HIF-1 plays an important role in the development and progression of many types of human diseases, including pathogen-associated cancers. In the present review, we summarize the recent understandings of how human pathogenic agents including viruses, bacteria and parasites deregulate cellular HIF-1 signaling pathway in their associated cancer cells, and highlight the common molecular mechanisms of HIF-1 signaling activated by these pathogenic infection, which could act as potential diagnostic markers and new therapeutic strategies against human infectious cancers...
October 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27470177/global-burden-of-cancers-attributable-to-infections-in-2012-a-synthetic-analysis
#18
Martyn Plummer, Catherine de Martel, Jerome Vignat, Jacques Ferlay, Freddie Bray, Silvia Franceschi
BACKGROUND: Infections with certain viruses, bacteria, and parasites are strong risk factors for specific cancers. As new cancer statistics and epidemiological findings have accumulated in the past 5 years, we aimed to assess the causal involvement of the main carcinogenic agents in different cancer types for the year 2012. METHODS: We considered ten infectious agents classified as carcinogenic to human beings by the International Agency for Research on Cancer. We calculated the number of new cancer cases in 2012 attributable to infections by country, by combining cancer incidence estimates (from GLOBOCAN 2012) with estimates of attributable fraction (AF) for the infectious agents...
September 2016: Lancet Global Health
https://www.readbyqxmd.com/read/27337218/identification-of-antimicrobial-peptides-by-using-eigenvectors
#19
Carlos Polanco
Antibacterial peptides are subject to broad research due to their potential application and the benefit they can provide for a wide range of diseases. In this work, a mathematical-computational method, called the Polarity Vector Method, is introduced that has a high discriminative level (>70%) to identify peptides associated with Gram (-) bacteria, Gram (+) bacteria, cancer cells, fungi, insects, mammalian cells, parasites, and viruses, taken from the Antimicrobial Peptides Database. This supervised method uses only eigenvectors from the incident polar matrix of the group studied...
2016: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/27242703/strategies-for-human-tumor-virus-discoveries-from-microscopic-observation-to-digital-transcriptome-subtraction
#20
REVIEW
Ezra D Mirvish, Masahiro Shuda
Over 20% of human cancers worldwide are associated with infectious agents, including viruses, bacteria, and parasites. Various methods have been used to identify human tumor viruses, including electron microscopic observations of viral particles, immunologic screening, cDNA library screening, nucleic acid hybridization, consensus PCR, viral DNA array chip, and representational difference analysis. With the Human Genome Project, a large amount of genetic information from humans and other organisms has accumulated over the last decade...
2016: Frontiers in Microbiology
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