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https://www.readbyqxmd.com/read/28225151/cytopathologic-differential-diagnosis-of-low-grade-urothelial-carcinoma-and-reactive-urothelial-proliferation-in-bladder-washings-a-logistic-regression-analysis
#1
Ebru Cakir, Ulku Kucuk, Emel Ebru Pala, Ozlem Sezer, Rahmi Gokhan Ekin, Ozgur Cakmak
Conventional cytomorphologic assessment is the first step to establish an accurate diagnosis in urinary cytology. In cytologic preparations, the separation of low-grade urothelial carcinoma (LGUC) from reactive urothelial proliferation (RUP) can be exceedingly difficult. The bladder washing cytologies of 32 LGUC and 29 RUP were reviewed. The cytologic slides were examined for the presence or absence of the 28 cytologic features. The cytologic criteria showing statistical significance in LGUC were increased numbers of monotonous single (non-umbrella) cells, three-dimensional cellular papillary clusters without fibrovascular cores, irregular bordered clusters, atypical single cells, irregular nuclear overlap, cytoplasmic homogeneity, increased N/C ratio, pleomorphism, nuclear border irregularity, nuclear eccentricity, elongated nuclei, and hyperchromasia (p ˂ 0...
February 22, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28217985/two-unusual-variants-of-pancreatic-neuroendocrine-tumor-and-their-potential-pitfalls-on-fine-needle-aspiration-cytology
#2
Abby M Richmond, Sanjana Mehrotra
Endoscopic ultrasound-guided fine-needle aspiration is increasingly utilized for the diagnosis of pancreatic lesions. Although operator dependent, the procedure has good overall performance characteristics and is minimally invasive; however, accuracy and sensitivity are reportedly lower for pancreatic neuroendocrine tumor (PanNET) compared with the more common pancreatic ductal adenocarcinoma (pACA). The underperformance is further exacerbated by the unusual cases of PanNET presenting with variant cytomorphology...
February 20, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28217140/evaluation-of-polymerase-chain-reaction-in-space-occupying-lesions-of-liver-reported-as-granulomatous-inflammation-tuberculosis-on-fine-needle-aspiration-cytology
#3
Kusum Sharma, Nalini Gupta, Kapil Goyal, Ajay Kumar Duseja, Aman Sharma, Arvind Rajwanshi
BACKGROUND: Tubercular involvement of the liver is uncommon, but is a serious consideration in differential diagnosis of granulomatous conditions, especially in endemic regions like India. OBJECTIVE: To assess the role of polymerase chain reaction (PCR) done on archival cytological material in diagnosing tuberculosis (TB) in cases reported as granulomatous inflammation/TB in liver lesions. MATERIALS AND METHODS: This was a retrospective study including a total of 17 cases of liver space-occupying lesions (SOLs) reported as granulomatous inflammation (n = 12) and TB (n = 5)...
2017: CytoJournal
https://www.readbyqxmd.com/read/28205397/pancreatic-involvement-by-metastasizing-neoplasms-as-determined-by-endoscopic-ultrasound-guided-fine-needle-aspiration-a-clinicopathologic-characterization
#4
Miroslav Sekulic, Khalid Amin, Tetyana Mettler, Lizette K Miller, Shawn Mallery, Jimmie Stewart
BACKGROUND: Pancreatic tumors often represent primary neoplasms, however organ involvement with metastatic disease can occur. The use of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) to determine the underlying pathology provides guidance of clinical management. METHODS: 25 cases were identified in a retrospective review of our institution's records from 2006 to 2016. Clinical parameters and prognosis are described. RESULTS: Metastatic lesions to the pancreas diagnosed by EUS-FNA accounted for 4...
February 16, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28194072/an-unusual-cause-of-fever-generalized-lymphadenopathy-and-eosinophilia-in-a-hcv-positive-6-year-old-boy
#5
Rajesh Kumar, Prashant Sharma, Pranab Dey, Babu Ram Thapa
A 6-year-old boy presented with a 3-month history of high-grade fever and night-sweats but without chills/rigors. On examination, he had moderate hepatosplenomegaly with multiple enlarged cervical and axillary lymph nodes. His hemogram revealed anemia and marked eosinophilia. Initial investigations were negative, except anti-HCV IgG antibodies, that were positive. Bone marrow aspirate showed a single histiocyte containing suspicious intracellular yeast-like forms. Cervical lymph node aspiration revealed a heavy load of intra- and extra-cellular Histoplasma spp...
March 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/28182082/cytomorphometric-analysis-and-morphological-assessment-of-oral-exfoliated-cells-in-type-2-diabetes-mellitus-and-healthy-individuals-a-comparative-study
#6
Khushboo Sahay, Shweta Rehani, Priyanka Kardam, Madhumani Kumra, Rashi Sharma, Nisha Singh
CONTEXT: Oral exfoliative cytology is a simple, nonaggressive technique that is well accepted by patients. Therefore, it is an attractive option, which aids in the diagnosis and observation of epithelial atypias associated with oral mucosal diseases. AIMS: The aim of this study was to evaluate and compare the quantitative and qualitative alterations in exfoliative smears from type 2 diabetics and healthy individuals. PATIENTS AND METHODS: The study includes 30 type 2 diabetics and 30 healthy persons of both sexes...
January 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28182077/penicillium-marneffei-infection-in-a-hiv-positive-patient-a-comparison-of-bronchial-washing-cytology-and-biopsy
#7
Chu Hyun Hee, Chong Young Pil, Kyung Ja Cho
Penicilliosis is a disseminated and progressive infection that is mainly found in immunocompromised individuals, especially those with human immunodeficiency virus (HIV) infection. Because of the high mortality of patients with disseminated Penicillium marneffei infection, rapid diagnosis and early treatment are required. Diagnosis is traditionally made by biopsy and/or culture of blood or any involved organ. Cytology offers several advantages over biopsy, including more rapid diagnosis and greater resolution of cytomorphologic details of organisms, allowing rapid initiation of treatment...
January 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28182067/sialosis-cytomorphological-significance-in-the-diagnosis-of-an-uncommon-entity
#8
Sunil Vitthalrao Jagtap, Shakuntala S Aramani, Avinash Mane, Vijay Bonde
A diffuse, chronic, usually bilateral, noninflammatory, nonneoplastic enlargement of major salivary glands is termed as Sialosis or Sialadenosis. It is an extremely uncommon cause for enlargement of the parotid gland. We hereby present a case of a 45-year-old female patient having a swelling at the left preauricular region. The swelling was gradually increasing in size since 6 months. On clinical examination, the swelling was 3 cm × 3 cm, mobile, and nontender. On ultrasonography, it was suggestive of benign parotid lesion or parotitis with cervical lymphadenopathy...
January 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28153131/laryngeal-dysplasia-squamous-cell-carcinoma-and-variants
#9
REVIEW
Lester D R Thompson
Squamous cell carcinoma (SCC) is a malignant epithelial tumor showing evidence of squamous differentiation. It is the most common malignancy of the larynx, with several variants (verrucous, exophytic or papillary, spindle-cell, basaloid, acantholytic, adenosquamous) recognized, with well-established precursor lesions. Dysplasia is now separated into only low-grade and high-grade categories. Each SCC variant has unique cytomorphologic features and histologic differential diagnoses that are important to consider, as management and outcomes are different...
March 2017: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/28149842/inertia-based-microfluidic-capture-and-characterisation-of-circulating-tumour-cells-for-the-diagnosis-of-lung-cancer
#10
Dimple Y Chudasama, Daria V Freydina, Maxim B Freidin, Maria Leung, Angeles Montero Fernandez, Alexandra Rice, Andrew G Nicholson, Emmanouil Karteris, Vladimir Anikin, Eric Lim
BACKGROUND: Routine clinical application of circulating tumour cells (CTCs) for blood based diagnostics is yet to be established. Despite growing evidence of their clinical utility for diagnosis, prognosis and treatment monitoring, the efficacy of a robust platform and universally accepted diagnostic criteria remain uncertain. We evaluate the diagnostic performance of a microfluidic CTC isolation platform using cytomorphologic criteria in patients undergoing lung cancer surgery. METHODS: Blood was processed from 51 patients undergoing surgery for known or suspected lung cancer using the ClearBridge ClearCell FX system(TM) (ClearBridge Biomedics, Singapore)...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28144203/socio-demographic-characteristics-of-patients-with-diagnosis-of-leukemia-in-bosnia-and-herzegovina-during-six-year-period
#11
Edo Hasanbegovic, Nedim Begic, Snijezana Hasanbegovic, Zijo Begic
INTRODUCTION: Malignancies in children are second most frequent cause of death after accidents in pediatric age, while leukemias represents 30% of all malignancies of children age. AIM: To present the social and demographic characteristics of patients with a diagnosis of leukemia in Bosnia and Herzegovina during six years period. PATIENTS AND METHODS: The study included 97 patients (from birth to 18 years old) with diagnosis of acute leukemia...
December 2016: Materia Socio-medica
https://www.readbyqxmd.com/read/28140514/classical-type-and-blastoid-variant-mantle-cell-lymphoma-in-the-same-lymph-node-histology-and-cytological-findings-from-a-touch-imprint-specimen
#12
Shin-Ichi Nakatsuka, Tadasuke Nagatomo, Teruaki Nagano, Takayoshi Goto, Koji Hashimoto
Blastoid variant (BV) is one of the aggressive variants of mantle cell lymphoma (MCL). BV-MCL is defined by its blastic cytomorphology. Previous studies using sequential biopsies in cases with MCL have demonstrated that classical type MCL (C-MCL) often transforms or relapses as an aggressive variant, but a histopathological transition from C-MCL to an aggressive MCL variant in the same pathological specimen has been shown in only a limited number of the cases. We present a case of MCL in which a histological transition between C-MCL and BV-MCL was observed in the same lymph node...
January 31, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28139898/fine-needle-aspiration-cytology-of-endometriosis
#13
Sharon J Song, Cindy M McGrath, Gordon H Yu
Endometriosis commonly involves the pelvis, but may also present as a palpable mass in extrapelvic sites, such as the abdominal wall or inguinal region, where it can be evaluated by fine needle aspiration (FNA). In this report, we illustrate the findings seen in seven cases of endometriosis diagnosed by FNA in patients with a chief complaint of pain associated with an abdominal wall or pelvic mass, occurring in a setting of prior pelvic surgery. The most common previous surgery was Cesarean section (n = 6), followed by hysterectomy (n = 2), and hernia repair (n = 1)...
January 31, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28119365/usefulness-of-kir3dl2-to-diagnose-follow-up-and-manage-the-treatment-of-s%C3%A3-zary-syndrome-patients
#14
Charlotte Hurabielle, Nicolas Thonnart, Caroline Ram-Wolff, Helene Sicard, Armand Bensussan, Martine Bagot, Anne Marie-Cardine
PURPOSE: KIR3DL2 is a recently discovered marker of the malignant clonal cell population in Sézary Syndrome (SS). We intended to evaluate the expression of KIR3DL2 on blood T-cells as a diagnostic, prognostic and follow-up marker of SS. EXPERIMENTAL DESIGN: 64 patients diagnosed with SS were included in this monocentric study. We collected the percentage of KIR3DL2+ cells among CD3+ T-cells, obtained by flow cytometry, and other classical diagnostic criteria for SS at diagnosis and during the follow-up...
January 24, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28112486/pleural-fluid-cytology-samples-in-cases-of-suspected-lung-cancer-an-experience-from-a-tertiary-care-centre
#15
Gurwinder Kaur, Raje Nijhawan, Nalini Gupta, Navneet Singh, Arvind Rajwanshi
OBJECTIVE: Pleural effusion is present in some patients with lung carcinoma. This study was undertaken to evaluate the role of pleural fluid cytology in suspected cases of lung carcinoma. METHODS: In this prospective study, 86 cases of suspected primary lung carcinoma associated with pleural effusion were included. Cytomorphology of conventional smears was combined with LBC smears and a cytomorphological diagnosis was offered. An immunopanel of CK7, CK5/6, p63, TTF1, calretinin, and CD56 was applied on cell blocks...
January 23, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28111796/establishment-and-characterization-of-a-coculture-system-of-equine-endometrial-epithelial-and-stromal-cells
#16
L Lapko, D Böttcher, T Theuß, J Klug, H-A Schoon
To investigate the equine endometrium as close to the in vivo situation as possible, we established a coculture system for epithelial and stromal cells (ECs/SCs). ECs and SCs were isolated from nine endometrial tissue specimens. ECs obtained as glandular formations were cultivated on one side of the semipermeable membrane of a Millicell(®) insert. After 2 days, SCs (2 × 10(4) cells/membrane) were seeded onto the other side of the same membrane. During cocultivation, the low serum containing culture medium (Theuß et al...
January 23, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28088186/concentration-of-fine-needle-aspirates-similar-to-molecular-method-improves-sensitivity-of-the-diagnosis-of-tuberculous-lymphadenitis-in-addis-ababa-ethiopia
#17
Olifan Zewdie, Tamrat Abebe, Adane Mihret, Eyob Hirpa, Gobena Ameni
BACKGROUND: Tuberculous lymphadenitis (TBLN) diagnosis has been a true challenge solely by clinical evidence in developing countries, due to limited the diagnostic facility on hand. However, the availability and affordability of available diagnostic tools in resource-limited settings like Ethiopia necessitates the quest for other techniques with added value over direct Z-N microscopy. Therefore, we aimed at to assess whether the concentration of lymph node aspirate similarly improves the detection rate of tuberculous lymphadenitis or not...
January 14, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28028343/cribriform-morular-variant-of-papillary-thyroid-carcinoma-cytomorphology-differential-diagnosis-and-diagnostic-implications-in-patients-with-adenomatous-polyposis-coli
#18
Amarathunga Ah Priyani, Shamika T Opatha, Nisayuri W Gunathilake, Menaka Ds Lokuhetty
Cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC), which has a better prognosis, is seen mostly in the setting of familial adenomatous polyposis (FAP). The cytomorphology of CMV-PTC is diverse; hence, it could be mistaken for other thyroid neoplasms with bad prognostic outcome. This case is of a 24-year-old female diagnosed with polyposis coli found to have thyroid nodules at screening ultrasonography. Aspirated thyroid smears were hypercellular with epithelial cells arranged in monolayer sheets, papillae with discohesion, and spindling of cells at the edges, cribriform clusters, and cell morules...
October 2016: Journal of Cytology
https://www.readbyqxmd.com/read/28028332/comparison-of-liquid-based-preparation-and-conventional-smear-of-fine-needle-aspiration-cytology-of-lymph-node
#19
Priya Singh, Manish Rohilla, Pranab Dey
BACKGROUND: In this paper, we have compared the cytomorphologic characteristics of liquid-based preparation (LBP) [SurePath (SP)] cytology and conventional smear (CP) preparations on fine-needle aspiration (FNAC) material by a semi-quantitative scoring system for cases of lymphadenopathy. MATERIALS AND METHODS: In this prospective study, a total of 52 consecutive cases of FNAC of lymphadenopathy were included. The first pass was used for CP followed by LBP with the help of SP technique...
October 2016: Journal of Cytology
https://www.readbyqxmd.com/read/28018211/cistanche-tubulosa-protects-dopaminergic-neurons-through-regulation-of-apoptosis-and-glial-cell-derived-neurotrophic-factor-in-vivo-and-in-vitro
#20
Qian Xu, Wen Fan, Shui-Fen Ye, Yi-Bo Cong, Wei Qin, Shi-Ya Chen, Jing Cai
Parkinson's disease (PD) is a neurodegenerative disease with the pathological hallmark of reduced nigrostriatal dopamine. In traditional Chinese medicine (TCM) clinical practice, the nanopowder of Cistanche tubulosa has therapeutic effects on PD. To identify the therapeutic mechanism, this study tested the protective effect of different doses of MPP(+)-induced toxicity in MES23.5 cells using the MTT assay and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice (vehicles). Immunohistochemistry was used to assess cytomorphology and tyrosine hydroxylase (TH) expression...
2016: Frontiers in Aging Neuroscience
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