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https://www.readbyqxmd.com/read/29772476/fate-of-nuclear-material-during-subsequent-steps-of-the-kinetin-induced-pcd-in-apical-parts-of-vicia-faba-ssp-minor-seedling-roots
#1
Andrzej Kaźmierczak, Kamila Soboska
In animals during apoptosis, the best examined type of programmed cell death (PCD), three main phases are distinguished: (i) specification (signaling), (ii) killing and (iii) execution one. It has bean postulated that plant PCD also involves three subsequent phases: (i) transmission of death signals to cells (signaling), (ii) initiation of killing processes and (iii) destruction of cells. One of the most important hallmarks of animal and plant PCD are those regarding nucleus, not thoroughly studied in plants so far...
April 30, 2018: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/29771690/heavily-pigmented-epithelioid-melanoma-with-loss-of-protein-kinase-a-regulatory-subunit-%C3%AE-expression
#2
Jarish N Cohen, Jessica A Spies, Fawn Ross, Angela Bohlke, Timothy H McCalmont
Heavily pigmented melanocytic neoplasms are genotypically and phenotypically diverse. Recently, a subset of this histopathologic spectrum was shown to harbor recurrent genetic alterations in the gene-encoding protein kinase A regulatory subunit-α (PRKAR1A). To date, no histopathologic descriptions of melanomas arising from this pathway have been described. We present a case of a darkly pigmented papule arising on the posterior neck of a 28-year-old man. Microscopically, the heavily pigmented compound melanocytic proliferation was centered in the dermis with permeation into the superficial subcutis...
May 16, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29766535/deceptively-bland-cutaneous-angiosarcoma-on-the-nose-mimicking-hemangioma-a-clinicopathologic-and-immunohistochemical-analysis
#3
Christina Mitteldorf, Mar Llamas-Velasco, Hans-Joachim Schulze, Kai-Martin Thoms, Thomas Mentzel, Michael Tronnier, Heinz Kutzner
BACKGROUND: We investigated two cases of deceptively bland cutaneous angiosarcoma, which showed a uniform clinical presentation with a rapidly growing tumor on the nose. It remains unclear whether this was a primary cutaneous manifestation or a metastasis. Both tumors initially presented a high histologic overlap with a benign vascular tumor. The diagnosis was primarily based on the rapidly progressing clinical course and on the results of the staging procedures. METHODS: Immunohistochemical stains were performed for cytokeratin (AE1/AE3 and MNF116), CD31, ERG, CD34(HPCA1/my10), D2-40/podoplanin, LYVE-1, Ki67, PHH3, αSMA(1A4), MYC, FOS-B, CAMTA-1, TFE-3, WT1, nestin, VEGFR-2(KDR), VEGFR-3(FLT4), HHV8...
May 15, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29757495/a-20-year-and-46-000-specimen-journey-to-paris-reveals-the-influence-of-reporting-systems-and-passive-peer-feedback-on-pathologist-practice-patterns
#4
Christopher J VandenBussche, Derek B Allison, Mohit Gupta, Syed Z Ali, Dorothy L Rosenthal
BACKGROUND: An important goal of The Paris System for Reporting Urinary Cytology (TPS) is to reduce unnecessary atypical diagnoses given to urinary tract cytology (UTC) specimens. Since implementation of TPS at the study institution in 2016, the institutional atypical rate has declined only slightly. The authors speculated that TPS might not have had an immediate impact because several faculty members were involved in TPS committees and because TPS contains elements that already had been integrated into institutional practice...
May 14, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29753057/histomorphologic-spectrum-of-germline-related-and-sporadic-bap-1-inactivated-melanocytic-tumors
#5
Erin M Garfield, Kara E Walton, Victor L Quan, Timothy VandenBoom, Bin Zhang, Betty Y Kong, Maria Cristina Isales, Elnaz Panah, Gene Kim, Pedram Gerami
BACKGROUND: BAP-1 inactivated melanocytic tumors (BIMTs) are often the earliest sign of the BAP-1 tumor predisposition syndrome. Identification of BIMTs and selection of patients for germline testing impacts the lives of patients with germline BAP-1 mutations. OBJECTIVE: We describe the spectrum of histomorphologic findings in BAP-1 inactivated melanocytic lesions to improve their recognition. We determined the frequency of sporadic versus germline cases in our cohort, assessing whether any features were statistically linked to germline status...
May 9, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29732727/cytomorphology-of-epithelioid-gastrointestinal-stromal-tumor
#6
Miguel Dario Cantu, Abha Goyal
No abstract text is available yet for this article.
May 6, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29732003/single-cell-genetic-analysis-validates-cytopathological-identification-of-circulating-cancer-cells-in-patients-with-clear-cell-renal-cell-carcinoma
#7
Lucile Broncy, Basma Ben Njima, Arnaud Méjean, Christophe Béroud, Khaled Ben Romdhane, Marius Ilie, Veronique Hofman, Jane Muret, Paul Hofman, Habiba Chaabouni Bouhamed, And Patrizia Paterlini-Bréchot
Context: Circulating Rare Cells (CRC) are non-haematological cells circulating in blood. They include Circulating Cancer Cells (CCC) and cells with uncertain malignant features (CRC-UMF) according to cytomorphology. Clear cell renal cell carcinomas frequently bear a mutated Von Hippel-Lindau (VHL) gene. Aim: To match blind genetic analysis of CRC and tumor samples with CRC cytopathological diagnosis. Results: 29/30 patients harboured CRC (20 harboured CCC, 29 CRC-UMF) and 25/29 patients carried VHL mutations in their tumour...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29728319/current-status-and-trends-in-the-diagnostics-of-aml-and-mds
#8
REVIEW
Evgenii Shumilov, Johanna Flach, Alexander Kohlmann, Yara Banz, Nicolas Bonadies, Martin Fiedler, Thomas Pabst, Ulrike Bacher
Diagnostics of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) have recently been experiencing extensive modifications regarding the incorporation of next-generation sequencing (NGS) strategies into established diagnostic algorithms, classification and risk stratification systems, and minimal residual disease (MRD) detection. Considering the increasing arsenal of targeted therapies (e.g. FLT3 or IDH1/IDH2 inhibitors) for AML, timely and comprehensive molecular mutation screening has arrived in daily practice...
April 27, 2018: Blood Reviews
https://www.readbyqxmd.com/read/29719560/cytomorphological-features-as-predictors-of-epidermal-growth-factor-receptor-mutation-status-in-lung-adenocarcinoma
#9
Saniya Sharma, Nalini Gupta, Navneet Singh, Rini Chaturvedi, Digambar Behera, Arvind Rajwanshi
Background: Epidermal growth factor receptor mutation-positive ( EGFR-p ) lung adenocarcinomas are sensitive to tyrosine kinase inhibitors. Although histopathological subtype is an independent predictor of mutation status, there is a paucity of data on the cytomorphological features correlating with the EGFR mutation status. Therefore, the aim of this study was to determine whether certain cytomorphological features correlate with EGFR mutation in lung adenocarcinoma. Materials and Methods: A retrospective analysis of 48 lung adenocarcinoma cases diagnosed on fine needle aspiration cytology with known EGFR mutation status was conducted...
2018: CytoJournal
https://www.readbyqxmd.com/read/29719022/approach-to-dermal-based-lymphoid-infiltrates-and-proliferations
#10
Yann Charli-Joseph, Sonia Toussaint-Claire, Carmen Lome-Maldonado, Daniel Montante-Montes de Oca, Carlos Ortiz-Hidalgo
The histopathological diagnosis of dermal-based lymphoid infiltrates and proliferations is often challenging due to the vast list of biologically diverse entities that archetypally or occasionally center in the mid-dermis, especially because significant overlap exists in their clinical, histopathologic, and immunophenotypic features. The differential diagnosis includes reactive infiltrates in common and rare inflammatory dermatoses, benign conditions that may mimic lymphoid neoplasms (pseudolymphomas), and true clonal proliferations arising either primarily in the skin or rarely in extracutaneous tissues with secondary cutaneous dissemination...
March 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29708525/establishment-of-a-primary-culture-of-patient-derived-soft-tissue-sarcoma
#11
Alessandro De Vita, Laura Mercatali, Giacomo Miserocchi, Chiara Liverani, Chiara Spadazzi, Federica Recine, Alberto Bongiovanni, Federica Pieri, Davide Cavaliere, Valentina Fausti, Dino Amadori, Toni Ibrahim
Soft tissue sarcomas (STS) represent a spectrum of heterogeneous malignancies with a difficult diagnosis, classification, and management. To date, more than 50 histological subtypes of these rare solid tumors have been identified. Thus, due to their extraordinary diversity and low incidence, our understanding of the biology of these tumors is still limited. Patient-derived cultures represent the ideal platform to study STS pathophysiology and pharmacology. We thus developed a human preclinical model of STS starting from tumor specimens harvested from patients undergoing surgical resection...
April 11, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29696405/gastric-washing-by-distilled-water-can-reduce-free-gastric-cancer-cells-exfoliated-into-the-stomach-lumen
#12
Atsuko Ohki, Nobutsugu Abe, Eri Yoshimoto, Yoshikazu Hashimoto, Hirohisa Takeuchi, Gen Nagao, Tadahiko Masaki, Toshiyuki Mori, Yasuo Ohkura, Masanori Sugiyama
PURPOSE: Intragastric free cancer cells in patients with gastric cancer have rarely been studied. The purpose of this study was to investigate the detection rate of intragastric free cancer cells in gastric washes using two types of solutions during endoscopic examination. We further clarified risk factors affecting the presence of exfoliated free cancer cells. METHODS: A total of 175 patients with gastric cancer were enrolled. Lactated Ringer's solution (N = 89) or distilled water (DW; N = 86) via endoscopic working channel was sprayed onto the tumor surface, and the resultant fluid was collected for cytological examination...
April 25, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/29686830/cytomorphological-spectrum-of-thyroiditis-a-review-of-110-cases
#13
Shirish S Chandanwale, Rahul Nair, Anushree Gambhir, Supreet Kaur, Aditi Pandey, Abhinav Shetty, Piyusha Naragude
Introduction: Different types of thyroiditis may share some parallel clinical and biochemical features. Timely intervention can significantly reduce morbidity and mortality. Aim: Aim of this study is to find the frequency of various thyroiditis, study the cytomorphological features and correlate with clinical findings including radiological findings, thyroid function test, and anti-thyroid peroxidase antibodies (Anti-TPO antibodies). Materials and Methods: The study included consecutive 110 cases of thyroiditis...
2018: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29676378/extranodal-histiocytic-sarcoma-in-a-child-with-acute-lymphoblastic-leukemia-cytomorphological-features-of-a-rare-entity-with-brief-review-of-literature
#14
Krushna Chandra Pani, Mahima Yadav, Shaleen Kumar, Vinita Agrawal
Histiocytic sarcoma (HS) is a rare malignant neoplasm showing morphologic and immunophenotypic evidence of histiocytic differentiation. We describe a rare case of synchronous HS in a patient of B-cell acute lymphoblastic leukemia (ALL). A 16-year-old boy diagnosed as ALL also presented with a swelling over the right Achilles tendon. The cytological features of the swelling suggested a histiocytic lesion. Histological and immunohistochemical examination clinched the diagnosis of HS. The available 5-year follow-up showed no recurrence...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29672900/metastatic-melanoma-with-balloon-histiocytoid-cytomorphology-after-treatment-with-immunotherapy-a-histologic-mimic-and-diagnostic-pitfall
#15
Maya Farah, Priyadharsini Nagarajan, Carlos A Torres-Cabala, Jonathan L Curry, Rodabe N Amaria, Jennifer Wargo, Hussein Tawbi, Doina Ivan, Victor G Prieto, Michael T Tetzlaff, Phyu P Aung
Epithelioid cells with foamy cytoplasm (histiocytoid features) are typical histopathologic findings among benign and malignant histiocytic neoplasms such as xanthoma and atypical fibroxanthoma. However, these changes are unusual in melanoma, which is typically composed of nested and variably pigmented atypical epithelioid cells. Here, we report a patient with metastatic melanoma in lymph nodes presenting with prominent balloon cell/histiocytoid features expressing melanocytic markers, after treatment with nivolumab...
April 19, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29669313/role-of-fna-and-special-stains-in-rapid-cytopathological-diagnosis-of-pulmonary-nocardiosis
#16
Ridhi Sood, Ruchita Tyagi, Pavneet Kaur Selhi, Gursheen Kaur, Harpreet Kaur, Akashdeep Singh
BACKGROUND: Nocardia, a gram-positive aerobic bacillus of the Actinomycetales family, is a significant opportunistic pathogen in immunocompromised individuals. Clinical and radiological features of pulmonary nocardiosis are nonspecific and can be misdiagnosed as tuberculosis, pneumocystis, staphylococcal or fungal infections, or as malignancy. Aspiration cytology with special stains is a quick and effective approach for accurate diagnosis. MATERIALS AND METHODS: We present 7 cases of pulmonary nocardiosis, admitted to the pathology department in a tertiary-care hospital in Punjab...
April 18, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29661735/fine-needle-aspiration-of-alveolar-soft-part-sarcoma-in-a-child-cytomorphological-clues-for-the-surgical-pathologist
#17
Mohamed Mostafa, Daniel Abbott, Lauren N Parsons
Alveolar soft part sarcoma (ASPS) is a rare soft tissue neoplasm generally affecting adolescents and young adults. Its unique histologic and ultrastructural features have been well-described; however, the cytopathological features of ASPS are less well-characterized, and recognition of this entity's features on cytologic preparations can ensure that the specimen adequacy and appropriate/rapid tissue allocation for additional testing. Herein we report a FNA case of ASPS with emphasis on cytomorphologic characteristics...
February 23, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29660830/cytologic-diagnosis-of-primary-peritoneal-high-grade-serous-carcinoma-in-a-man
#18
Brandon Umphress, John Philip, Yaxia Zhang, Xiaoqi Lin
Primary peritoneal serous carcinoma (PPSC) is a rare neoplasm histologically indistinguishable from ovarian serous carcinoma primarily occurring in the female population. To date, extremely rare cases of PPSC have been reported in men; however, diagnosis by cytology has yet to be described. Here we present the clinical, radiographic, cytomorphologic, histologic and immunohistochemical (IHC) findings of a high-grade (HG) PPSC in a 70-year-old man with a history of prostatic adenocarcinoma. Core needle biopsy (CNB) touch preparation smears showed pleomorphic, round, columnar and polygonal epithelioid cells present singly or arranged in loosely cohesive three-dimensional clusters...
April 16, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29643652/utility-of-cytokeratin7-immunocytochemistry-in-the-cytopathological-diagnosis-of-fibrolamellar-hepatocellular-carcinoma
#19
Rashi Garg, Radhika Srinivasan, Pranab Dey, Priya Singh, Nalini Gupta, Arvind Rajwanshi
Objective: To distinguish fibrolamellar hepatocellular carcinoma (FL-HCC) variant from the conventional hepatocellular carcinoma (HCC) by cytology, immunocytochemistry, and morphometry. Study Design: Retrospective detailed cytomorphological, immunocytochemical, and morphometric analysis was performed in 6 cases of FL-HCC reported on fine needle aspiration. Cell block immunocytochemistry (CB-ICC) for CK7 and CD68 was performed in four cases. Morphometry was carried out with Cell A software...
April 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29630086/isolated-epitrochlear-filarial-lymphadenopathy-cytomorphological-diagnosis-of-an-unusual-presentation
#20
Priya Sahu, Prajwala Gupta, Minakshi Bhardwaj, C K Durga
Filariasis is a major public health problem in tropical countries like India. Despite the large number of people at risk, detection of eggs with or without larva (microfilaria) on fine-needle aspiration cytology is very unusual, especially in an uncommon site or incidentally detected in clinically unsuspected cases of filariasis with the absence of microfilariae in the peripheral blood. A 19-year-old male presented with swelling over medial aspect of left arm (just above the elbow), with no other specific signs and symptoms...
April 9, 2018: Türk Patoloji Dergisi
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