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Keywords Prevention of venous thromboem...

Prevention of venous thromboembolism

https://read.qxmd.com/read/38536431/enhancing-safety-in-tumescent-liposuction-managing-sedation-related-respiratory-issues-and-serious-complications-under-deep-sedation-with-the-propofol-ketamine-protocol
#1
JOURNAL ARTICLE
Eun Ju Kim, Hyunju Kim, Younchan Park
BACKGROUND: Over the past 4 years, aesthetic surgery, notably liposuction, has substantially increased. Tumescent liposuction, a popular technique, has two variants-true tumescent liposuction (TTL) and semi-tumescent liposuction. While TTL reduces risks, it has limitations. There is no literature reported on semi-tumescent liposuction under deep sedation using the propofol-ketamine protocol, which is proposed as a potentially safe alternative. METHODS: The retrospective analysis covered 8 years and included 3094 patients performed for tumescent liposuction under deep sedation, utilizing the propofol-ketamine protocol...
March 27, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38534886/drug-drug-interactions-of-fxi-inhibitors-clinical-relevance
#2
REVIEW
Nicola Ferri, Elisa Colombo, Alberto Corsini
Inhibitors of the factor FXI represent a new class of anticoagulant agents that are facing clinical approval for the treatment of acute coronary syndrome (ACS), venous thromboembolism (VTE), and stroke prevention of atrial fibrillation (AF). These new inhibitors include chemical small molecules (asundexian and milvexian), monoclonal antibodies (abelacimab, osocimab, and xisomab), and antisense oligonucleotides (IONIS-FXIRX and fesomersen), and thus, they have very peculiar and different pharmacokinetic and pharmacodynamic properties...
March 21, 2024: Hematology Reports
https://read.qxmd.com/read/38532864/randomized-clinical-trial-of-aspirin-as-prophylaxis-for-thromboembolism-in-hip-arthroplasty
#3
JOURNAL ARTICLE
Raul Carneiro Lins, Epitacio Rolim, Yago Andrade Lima, Rodrigo Rodrigues de Sousa Moura
OBJECTIVE: This study aims to evaluate aspirin as a chemical prophylaxis (200 mg) in total hip arthroplasty. METHODS: the study compared two groups and used ultrasonography (USG) to screen for low-deep venous thrombosis. Group 1 received 600 mg (control), and Group 2 received 200 mg of (intervention), associated with the use of elastic compression stockings and early walking. RESULTS: fourteen patients were allocated to Group A (200mg), and 16 to Group B (600mg); in group A (200mg), 3 cases with thrombus below the popliteal vein were detected at the first USG examination...
2024: Acta Ortopedica Brasileira
https://read.qxmd.com/read/38531623/risk-stratification-based-thromboprophylaxis-does-not-affect-mortality-after-fast-track-hip-and-knee-arthroplasty
#4
JOURNAL ARTICLE
Annette M Moisander, Konsta Pamilo, Jukka Huopio, Hannu Kautiainen, Anne Kuitunen, Juha Paloneva
BACKGROUND AND PURPOSE: Use of thromboprophylaxis effectively prevents pulmonary embolism (PE) and deaths after total hip and knee arthroplasty (THA and TKA). The optimum length of thromboprophylaxis is not known and has traditionally been based on the type of operation. Nowadays, a more individualized approach is preferred. This study analyzed if risk stratification-based planning of thromboprophylaxis has an association with the all-cause mortality after fast-track THA and TKA. PATIENTS AND METHODS: We compared fast-track THAs and TKAs operated between 2015-2016 and 2020-2021...
March 26, 2024: Acta Anaesthesiologica Scandinavica
https://read.qxmd.com/read/38529544/incidence-of-symptomatic-venous-thromboembolisms-in-stroke-patients
#5
JOURNAL ARTICLE
Mostafa Al Turk, Michael Abraham
Venous thromboembolism (VTE) is a common but preventable complication observed in critically ill patients. Deep vein thrombosis (DVT) is the most common type of VTE, with clinical significance based on location and symptoms. There is an increased incidence of DVT and pulmonary embolism (PE) in ischemic stroke patients using unfractionated heparin (UFH) for VTE prophylaxis compared with those using enoxaparin. However, UFH is still used in some patients due to its perceived safety, despite conflicting literature suggesting that enoxaparin may have a protective effect...
March 26, 2024: Journal of Intensive Care Medicine
https://read.qxmd.com/read/38529392/the-thrombotic-risk-in-cushing-s-syndrome-questions-answers-and-the-algorithm-to-consider-in-its-assessment-part-i-thrombotic-risk-not-related-to-surgery
#6
REVIEW
Agata Hanna Bryk-Wiązania, Mari Minasyan, Renata Świątkowska-Stodulska, Anetta Undas, Alicja Hubalewska-Dydejczyk, Susan M Webb, Elena Valassi, Aleksandra Gilis-Januszewska
INTRODUCTION: Recently, it has been reported that there is a great diversity in strategies used for thromboprophylaxis in patients with Cushing's syndrome (CS). An aim of this review was to discuss these practices in light of the existing data on the thrombotic risk in patients with CS and guidelines for medically ill patients. METHODS: The four relevant topics and questions on thrombotic risk in CS were identified. The current guidelines on prevention and diagnosis of venous thromboembolism (VTE) were reviewed for the answers...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38529183/unlocking-the-potential-of-fondaparinux-guideline-for-optimal-usage-and-clinical-suggestions-2023
#7
REVIEW
Qinan Yin, Lizhu Han, Yin Wang, Fengjiao Kang, Fengqun Cai, Liuyun Wu, Xingyue Zheng, Lian Li, Li E Dong, Limei Dong, Shuhong Liang, Min Chen, Yong Yang, Yuan Bian
Background: Thromboembolic disease is associated with a high rate of disability or death and gravely jeopardizes people's health and places considerable financial pressure on society. The primary treatment for thromboembolic illness is anticoagulant medication. Fondaparinux, a parenteral anticoagulant medicine, is still used but is confusing due to its disparate domestic and international indications and lack of knowledge about its usage. Its off-label drug usage in therapeutic settings and irrational drug use are also common...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38527140/does-thrombosis-play-a-causal-role-in-lacunar-stroke-and-cerebral-small-vessel-disease
#8
JOURNAL ARTICLE
Fatemeh Koohi, Eric L Harshfield, Alexey Shatunov, Hugh S Markus
BACKGROUND: The importance of thromboembolism in the pathogenesis of lacunar stroke (LS), resulting from cerebral small vessel disease (cSVD), is debated, and although antiplatelets are widely used in secondary prevention after LS, there is limited trial evidence from well-subtyped patients to support this approach. We sought to evaluate whether altered anticoagulation plays a causal role in LS and cSVD using 2-sample Mendelian randomization. METHODS: From a recent genome-wide association study (n=81 190), we used 119 genetic variants associated with venous thrombosis at genome-wide significance ( P <5*10-8 ) and with a linkage disequilibrium r2 <0...
April 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38523134/american-association-for-the-surgery-of-trauma-american-college-of-surgeons-committee-on-trauma-clinical-protocol-for-post-discharge-venous-thromboembolism-prophylaxis-after-trauma
#9
JOURNAL ARTICLE
Allison E Berndtson, Alisa Cross, Brian K Yorkgitis, Ryan Kennedy, Matthew P Kochuba, Christopher Tignanelli, Gail T Tominaga, David G Jacobs, Dennis W Ashley, Eric J Ley, Lena Napolitano, Todd W Costantini
Trauma patients are at an elevated risk for developing venous thromboembolism (VTE), which includes pulmonary embolism and deep vein thrombosis. In the inpatient setting, prompt pharmacologic prophylaxis is utilized to prevent VTE. For patients with lower extremity fractures or limited mobility, VTE risk does not return to baseline levels post-discharge. Currently, there are limited data to guide post-discharge VTE prophylaxis in trauma patients. The goal of these post-discharge VTE prophylaxis guidelines are to identify patients at the highest risk of developing VTE after discharge and to offer pharmacologic prophylaxis strategies to limit this risk...
March 25, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38522096/machine-learning-natural-language-processing-for-identifying-venous-thromboembolism-systematic-review-and-meta-analysis
#10
JOURNAL ARTICLE
Barbara D Lam, Pavlina Chrysafi, Thita Chiasakul, Harshit Khosla, Dimitra Karagkouni, Megan McNichol, Alys Adamski, Nimia Reyes, Karon Abe, Simon Mantha, Ioannis S Vlachos, Jeffrey I Zwicker, Rushad Patell
Venous thromboembolism (VTE) is a leading cause of preventable in-hospital mortality. Monitoring VTE cases is limited by the challenges of manual chart review and diagnosis code interpretation. Natural language processing (NLP) can automate the process. Rule-based NLP methods are effective but time consuming. Machine learning (ML)-NLP methods present a promising solution. We conducted a systematic review and meta-analysis of studies published before May 2023 that use ML-NLP to identify VTE diagnoses in the electronic health records...
March 24, 2024: Blood Advances
https://read.qxmd.com/read/38521524/tailored-anticoagulant-treatment-after-a-first-venous-thromboembolism-protocol-of-the-leiden-thrombosis-recurrence-risk-prevention-l-trrip-study-cohort-based-randomised-controlled-trial
#11
JOURNAL ARTICLE
J Louise I Burggraaf-van Delft, Nienke van Rein, Remy H H Bemelmans, Jan-Willem K van den Berg, Coty Y Bruggeman, Marissa Cloos-van Balen, Michiel Coppens, Matthijs Eefting, Yvonne Ende-Verhaar, Nick van Es, Coen van Guldener, Wouter K de Jong, Fleur Kleijwegt, Ted Koster, Cees Kroon, Saskia Kuipers, Jenneke Leentjens, Dieuwke Luijten, Albert T A Mairuhu, Karina Meijer, Marcel A van de Ree, Rick Roos, Ilse Schrover, Janneke Swart-Heikens, Annette W G van der Velden, Elske M van den Akker-van Marle, Saskia le Cessie, Geert-Jan Geersing, Saskia Middeldorp, Menno V Huisman, Frederikus A Klok, Suzanne C Cannegieter
INTRODUCTION: Patients with a first venous thromboembolism (VTE) are at risk of recurrence. Recurrent VTE (rVTE) can be prevented by extended anticoagulant therapy, but this comes at the cost of an increased risk of bleeding. It is still uncertain whether patients with an intermediate recurrence risk or with a high recurrence and high bleeding risk will benefit from extended anticoagulant treatment, and whether a strategy where anticoagulant duration is tailored on the predicted risks of rVTE and bleeding can improve outcomes...
March 23, 2024: BMJ Open
https://read.qxmd.com/read/38518208/weight-based-dosing-for-low-molecular-weight-heparin-enoxaparin-administration-to-achieve-optimal-vte-prophylaxis-in-trauma-patients
#12
JOURNAL ARTICLE
Tarendeep Thind, Thomas Heye, Curran Henson, Rebecca Reif, Hanna K Jensen, Kyle J Kalkwarf, Avi Bhavaraju, Ronald Robertson, Allison Jenkins
INTRODUCTION: Patients admitted after traumatic injuries are at high risk for developing venous thromboembolism (VTE). Low-molecular-weight heparin (LMWH) is commonly used to prevent VTE in this patient population; however, the optimal dosing strategy has yet to be determined. To address this question, a fixed-dosing strategy of LMWH was compared to a weight-based dosing strategy of LMWH for VTE prophylaxis. METHODS: A retrospective, pre-post implementation cohort study compared a fixed vs a weight-based dosing strategy of LMWH for VTE prophylaxis...
March 22, 2024: American Surgeon
https://read.qxmd.com/read/38513312/mechanical-properties-of-clot-made-from-human-and-bovine-whole-blood-differ-significantly
#13
JOURNAL ARTICLE
Gabriella P Sugerman, Grace N Bechtel, Zuzanna Malinowska, Sapun H Parekh, Manuel K Rausch
Thromboembolism - that is, clot formation and the subsequent fragmentation of clot - is a leading cause of death worldwide. Clots' mechanical properties are critical determinants of both the embolization process and the pathophysiological consequences thereof. Thus, understanding and quantifying the mechanical properties of clots is important to our ability to treat and prevent thromboembolic disease. However, assessing these properties from in vivo clots is experimentally challenging. Therefore, we and others have turned to studying in vitro clot mimics instead...
March 15, 2024: Journal of the Mechanical Behavior of Biomedical Materials
https://read.qxmd.com/read/38510855/effect-of-obesity-on-surgical-outcomes-and-complication-rates-in-pediatric-patients-a-comprehensive-systematic-review-and-meta-analysis
#14
REVIEW
Yeisson Rivero-Moreno, Andrea Garcia, Miguel Rivas-Perez, Jesus Coa-Bracho, Yoalkris Salcedo, Gabriel Gonzalez-Quinde, Erinor Montero-Palma, Denisse Valdivia-Sepulveda, Marialejandra Paz-Castillo, Debbye Machado-Paled, Wilson Garcia-Cazorla, Katheryn Acero-Alvarracín, Laila Tarabey-Yunis, Cesar Estrella-Gaibor
Obesity is one of the primary public health problems faced by children. The increased incidence of obesity in the pediatric population poses significant challenges during and after surgical procedures. This systematic review and meta-analysis aimed to understand to what extent obesity is to surgical complications in pediatric patients. A systematic database search of PubMed, Web of Science, Scopus, and Science Direct was performed in June 2023. According to the inclusion and exclusion criteria, two evaluators independently conducted literature screening, data extraction, and quality evaluation of the retrieved literature...
February 2024: Curēus
https://read.qxmd.com/read/38510098/endovascular-release-of-an-adams-deweese-clip-and-iliocaval-reconstruction-for-debilitating-lower-extremity-swelling
#15
Eric Sung, Joel L Ramirez, Devin Zarkowsky
More than 10 million cases of venous thromboembolisms are reported on an annual basis and are major contributors to morbidity and mortality. Studies have found that ≤90% of pulmonary embolisms originate from the abdominal and lower extremity veins. The mainstay of venous thromboembolism treatment has been, and still continues to be, anticoagulation. However, for patients for whom anticoagulation is contraindicated or has failed, physicians have turned to surgical innovations such as inferior vena cava (IVC) filters to create partial interruption of the IVC...
June 2024: Journal of Vascular Surgery Cases and Innovative Techniques
https://read.qxmd.com/read/38500844/the-association-of-anticoagulation-intensity-with-outcomes-in-hospitalized-covid-19-patients
#16
JOURNAL ARTICLE
Rena Zheng, Alexandra Solomon, Madeline DiLorenzo, Iniya Rajendran, Joseph Park, Vrushali Dhongade, Michael A Garcia, Robert T Eberhardt, John Mark Sloan, Janice Weinberg, Elizabeth S Klings
Venous thromboembolism (VTE) risk is increased in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A key question was whether increased intensity of anticoagulation would help prevent VTE and improve patient outcomes, including transfer to the intensive care unit (ICU) and mortality. At the start of the coronavirus disease-19 (COVID-19) pandemic, our institution, Boston Medical Center, instituted a VTE risk stratification protocol based on patients' initial D-dimer levels, medical history, and presence of thrombosis to determine whether they should receive standard-dose prophylaxis, high-dose prophylaxis, or therapeutic anticoagulation...
2024: Advances in Hematology
https://read.qxmd.com/read/38499699/association-between-systemic-sclerosis-and-risk-of-cerebrovascular-and-cardiovascular-disease-a-meta-analysis
#17
JOURNAL ARTICLE
I-Wen Chen, Wei-Ting Wang, Yi-Chen Lai, Chien-Ming Lin, Ping-Hsin Liu, Su-Zhen Wu, Kuo-Chuan Hung
We aimed to evaluate the association between systemic sclerosis (SSc) and major cerebrovascular/cardiovascular risks through a systematic approach. Databases were systematically searched from their inception to October 10, 2023 for studies comparing cerebrovascular/cardiovascular event rates between patients with SSc and controls. The primary outcome was the stroke risk in patients with SSc. Secondary outcomes included risk of myocardial infarction (MI), cardiovascular disease (CVD), peripheral vascular disease (PVD), and venous thromboembolism (VTE)...
March 18, 2024: Scientific Reports
https://read.qxmd.com/read/38496151/elastic-banding-compression-as-a-novel-treatment-to-maintain-hemodynamics-in-a-patient-with-klippel-trenaunay-syndrome
#18
Satoshi Kamiya, Takahiro Kato, Masakazu Yasuuji, Hiroyuki Tanaka, Yasuo M Tsutsumi
Klippel-Trenaunay syndrome (KTS) is also associated with venous thrombosis originating from varicose veins in the lower extremities, pulmonary embolism, and pulmonary hypertension. This study describes the anesthetic management of laparoscopic cholecystectomy in a 54-year-old male KTS patient with orthostatic hypotension due to massive varicose veins in the lower extremities and pulmonary thromboembolism. Compressing the varicosities with an elastic bandage can maintain stable circulatory dynamics even under general anesthesia management to prevent position and insufflation-induced changes that can occur spontaneously...
February 2024: Curēus
https://read.qxmd.com/read/38493138/association-of-interleukin-6-ferritin-and-lactate-dehydrogenase-with-venous-thromboembolism-in-covid-19-a-systematic-review-and-meta-analysis
#19
Haiyu Liu, Ningjing Guo, Qixian Zheng, Qianyuan Zhang, Jinghan Chen, Yuanyuan Cai, Qiong Luo, Qian Xu, Xiangqi Chen, Sheng Yang, Suyun Zhang
BACKGROUND: Coronavirus disease 2019 (COVID-19) is frequntly accompanied by venous thromboembolism (VTE), and its mechanism may be related to the abnormal inflammation and immune status of COVID-19 patients. It has been proved that interleukin-6 (IL-6), ferritin and lactate dehydrogenase (LDH) may play an important role in the occurrence of VTE in COVID-19 infection. But whether they can server as predictors for VTE in COVID-19 is still unclear. In this study, we performed a systematic review and meta-analysis to compare IL-6, ferritin and LDH in VTE and non-VTE COVID-19 patients in order to shed light on the prevention and treatment of VTE...
March 16, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38489128/effect-of-hypothyroidism-on-short-term-outcomes-after-autologous-and-implant-based-breast-reconstruction
#20
JOURNAL ARTICLE
Renxi Li, Bharat Ranganath
Hypothyroidism has high prevalence in elderly women, which overlaps with the patient population who opt for post-mastectomy breast reconstruction. While hypothyroidism was shown to impact outcomes in other surgeries, its effect on breast reconstruction has not been established. This study aimed to compare the short-term outcomes of patients with and without hypothyroidism who underwent autologous (ABR) and implant-based breast reconstruction (IBR), respectively. Patients having ABR or IBR were identified in the National Inpatient Sample from Q4 2015-2020...
March 15, 2024: Updates in Surgery
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