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https://www.readbyqxmd.com/read/29666364/improved-calcium-sensor-gcamp-x-overcomes-the-calcium-channel-perturbations-induced-by-the-calmodulin-in-gcamp
#1
Yaxiong Yang, Nan Liu, Yuanyuan He, Yuxia Liu, Lin Ge, Linzhi Zou, Sen Song, Wei Xiong, Xiaodong Liu
GCaMP, one popular type of genetically-encoded Ca2+ indicator, has been associated with various side-effects. Here we unveil the intrinsic problem prevailing over different versions and applications, showing that GCaMP containing CaM (calmodulin) interferes with both gating and signaling of L-type calcium channels (CaV 1). GCaMP acts as an impaired apoCaM and Ca2+ /CaM, both critical to CaV 1, which disrupts Ca2+ dynamics and gene expression. We then design and implement GCaMP-X, by incorporating an extra apoCaM-binding motif, effectively protecting CaV 1-dependent excitation-transcription coupling from perturbations...
April 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29665482/thermal-conditions-in-selected-urban-and-semi-natural-habitats-important-for-the-forensic-entomology
#2
Marek Michalski, Jerzy Nadolski
A long-term study on thermal conditions in selected urban and semi-natural habitats, where human corpses are likely to be found, was conducted in the city of Lodz (Central Poland). Thermal data were collected during two years at nine sites and compared with corresponding data from the nearest permanent meteorological station at Lodz Airport (ICAO code: EPLL). The conditions closest to those at the meteorological station prevailed in the deciduous forest, coefficient of determination R2 for those sets of data was above 0...
April 3, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29665015/the-bacterium-pseudomonas-aeruginosa-senses-and-gradually-responds-to-inter-specific-competition-for-iron
#3
Anne Leinweber, Michael Weigert, Rolf Kümmerli
Phenotypic plasticity in response to competition is a well-described phenomenon in higher organisms. Here, we show that also bacteria have the ability to sense the presence of competitors and mount fine-tuned responses to match prevailing levels of competition. In our experiments, we studied inter-specific competition for iron between the bacterium Pseudomonas aeruginosa (PA) and its competitor Burkholderia cenocepacia (BC). We focused on the ability of PA to phenotypically adjust the production of pyoverdine, an iron-scavenging siderophore...
April 17, 2018: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/29664153/using-the-advocacy-coalition-framework-and-multiple-streams-policy-theories-to-examine-the-role-of-evidence-research-and-other-types-of-knowledge-in-drug-policy
#4
Alison Ritter, Caitlin Elizabeth Hughes, Kari Lancaster, Robert Hoppe
BACKGROUND AND AIMS: The prevailing 'evidence-based policy' paradigm emphasizes a technical-rational relationship between alcohol and drug research evidence and subsequent policy action. However, policy process theories do not start with this premise, and hence provide an opportunity to consider anew the ways in which evidence, research and other types of knowledge impact upon policy. This paper presents a case study, the police deployment of drug detection dogs, to highlight how two prominent policy theories [the Advocacy Coalition Framework (ACF) and the Multiple Streams (MS) approach] explicate the relationship between evidence and policy...
April 17, 2018: Addiction
https://www.readbyqxmd.com/read/29661442/weight-gain-and-acute-rejection-in-patients-submitted-to-pulmonary-transplantation-a-retrospective-cohort-of-10-years
#5
I Carvalho Araújo, L Proença Vieira, A C di Creddo Alves, M Naoyuki Samano, R H de Oliveira Braga Teixeira
OBJECTIVE: Acute rejection is one of the most common complications after pulmonary transplantation. The aim of this work was to verify the association of nutritional status and weight gain with acute rejection in the recipient during the 1st year after pulmonary transplantation. METHODS: Retrospective cohort study with patients submitted to pulmonary transplantation at a pulmonary transplantation center in the state of São Paulo. Data on sex, age, underlying disease, type of transplantation, and presence, degree, and frequency of rejection according to the transbronchial biopsy results were collected, along with body mass index (BMI) and weight variation over the course of 1 year...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29661057/are-the-motivational-effects-of-autonomy-supportive-conditions-universal-contrasting-results-among-indians-and-americans
#6
Ritu Tripathi, Daniel Cervone, Krishna Savani
In Western theories of motivation, autonomy is conceived as a universal motivator of human action; enhancing autonomy is expected to increase motivation panculturally. Using a novel online experimental paradigm that afforded a behavioral measure of motivation, we found that, contrary to this prevailing view, autonomy cues affect motivation differently among American and Indian corporate professionals. Autonomy-supportive instructions increased motivation among Americans but decreased motivation among Indians...
April 1, 2018: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/29660612/perfluoroalkyl-substances-and-glycemic-status-in-pregnant-danish-women-the-odense-child-cohort
#7
Richard Christian Jensen, Dorte Glintborg, Clara Amalie Gade Timmermann, Flemming Nielsen, Henriette Boye Kyhl, Helle Raun Andersen, Philippe Grandjean, Tina Kold Jensen, Marianne Andersen
BACKGROUND: Perfluoroalkyl substances (PFASs) are persistent chemicals with suspected endocrine disrupting abilities applied in consumer products. PFASs have potentially modulating effects on glucose homeostasis. Insulin resistance prevails during third trimester of pregnancy, and this challenge of glucose homeostasis may reveal putative effects of PFAS concentrations on glycemic status. OBJECTIVE: To investigate associations between five serum PFASs and glucose-related outcomes in pregnant Danish women based on their risk of gestational diabetes mellitus (GDM)...
April 13, 2018: Environment International
https://www.readbyqxmd.com/read/29660396/analysis-of-clinical-management-of-infected-breast-implants-and-of-factors-associated-to-successful-breast-pocket-salvage-in-infections-occurring-after-breast-reconstruction
#8
Simonetta Franchelli, Marianna Pesce, Ilaria Baldelli, Anna Marchese, Pierluigi Santi, Andrea De Maria
OBJECTIVES: Considerable efforts have been devoted so far to improve salvage procedures of infected breast implants in absence of defined guidelines or validated clinical protocols. Within a cohort of prospectively recruited patients who underwent breast reconstruction, we performed a retrospective review of proven implant infections in order to describe factors contributing to management success. METHODS: We collected data in 1293 consecutive patients who underwent two stage (expander+ prosthesis) breast reconstruction with at least 12 months of follow-up...
April 13, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29659949/emc10-governs-male-fertility-via-maintaining-sperm-ion-balance
#9
Yuchuan Zhou, Fei Wu, Man Zhang, Zuquan Xiong, Qianqian Yin, Yanfei Ru, Huijuan Shi, Jinsong Li, Shanhua Mao, Yanliang Li, Xinyi Cao, Renming Hu, Chong Wee Liew, Qiang Ding, Xuanchun Wang, Yonglian Zhang
Infertility is a severe public health problem worldwide that prevails up to 15% in reproductive-age couples, and male infertility accounts for half of total infertility. Studies on genetically modified animal models have identified lots of genes involved in the pathogenesis of male infertility. The underlying causes, however, remain largely unclear. In this study, we provide evidence that EMC10, one subunit of endoplasmic reticulum (ER) membrane protein complex (EMC), is required for male fertility. EMC10 is significantly decreased in spermatozoa from patients with asthenozoospermia and positively associated with human sperm motility...
April 6, 2018: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/29657859/a-survey-of-practices-for-the-use-of-electronic-health-records-to-support-research-recruitment
#10
Jihad S Obeid, Laura M Beskow, Marie Rape, Ramkiran Gouripeddi, R Anthony Black, James J Cimino, Peter J Embi, Chunhua Weng, Rebecca Marnocha, John B Buse
Electronic health records (EHRs) provide great promise for identifying cohorts and enhancing research recruitment. Such approaches are sorely needed, but there are few descriptions in the literature of prevailing practices to guide their use. A multidisciplinary workgroup was formed to examine current practices in the use of EHRs in recruitment and to propose future directions. The group surveyed consortium members regarding current practices. Over 98% of the Clinical and Translational Science Award Consortium responded to the survey...
August 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29657780/phylogeny-biogeography-and-diversification-patterns-of-side-necked-turtles-testudines-pleurodira
#11
Gabriel S Ferreira, Mario Bronzati, Max C Langer, Juliana Sterli
Pleurodires or side-necked turtles are today restricted to freshwater environments of South America, Africa-Madagascar and Australia, but in the past they were distributed much more broadly, being found also on Eurasia, India and North America, and marine environments. Two hypotheses were proposed to explain this distribution; in the first, vicariance would have shaped the current geographical distribution and, in the second, extinctions constrained a previously widespread distribution. Here, we aim to reconstruct pleurodiran biogeographic history and diversification patterns based on a new phylogenetic hypothesis recovered from the analysis of the largest morphological dataset yet compiled for the lineage, testing which biogeographical process prevailed during its evolutionary history...
March 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29657416/prevailing-practices-in-the-use-of-antibiotics-by-dairy-farmers-in-eastern-haryana-region-of-india
#12
Vikash Kumar, Jancy Gupta
Aim: The aim of the study was to assess the antibiotic use in dairy animals and to trace its usage pattern among the small, medium, and large dairy farmers in Eastern Haryana region of India. Materials and Methods: Karnal and Kurukshetra districts from Eastern region of Haryana state were purposively selected, and four villages from each district were selected randomly. From each village, 21 farmers were selected using stratified random sampling by categorizing into small, medium, and large farmers constituting a total of 168 farmers as respondents...
March 2018: Veterinary World
https://www.readbyqxmd.com/read/29657308/characteristics-of-the-gut-microbiota-in-adult-patients-with-type-1-and-2-diabetes-based-on-the-analysis-of-a-fragment-of-16s-rrna-gene-using-next-generation-sequencing
#13
Dominika Salamon, Agnieszka Sroka-Oleksiak, Przemysław Kapusta, Magdalena Szopa, Sandra Mrozińska, Agnieszka H Ludwig-Słomczyńska, Paweł P Wołkow, Małgorzata Bulanda, Tomasz Klupa, Maciej T Małecki, Tomasz Gosiewski
INTRODUCTION    Scientific data indicate  a possible influence of the gastrointestinal tract microbiota on the development of type 1 (T1DM) and 2 (T2DM) diabetes. Sequence analysis of 16S rRNA identified several hundred bacterial species of the intestinal ecosystem, most of which cannot be cultured. OBJECTIVES    We aimed at evaluating the composition of the gut microbiota in adult patients with T1DM and T2DM and establishing a link between data obtained from microbiological testing and the patients' clinical data...
April 15, 2018: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29657242/diagnosis-related-group-drg-based-case-mix-funding-system-a-promising-alternative-for-fee-for-service-payment-in-china
#14
Cuirong Zhao, Chao Wang, Chengwu Shen, Qian Wang
Fee for services (FFS) is the prevailing method of payment in most Chinese public hospitals. Under this retrospective payment system, medical care providers are paid based on medical services and tend to over-treat to maximize their income, thereby contributing to rising medical costs and uncontrollable health expenditures to a large extent. Payment reform needs to be promptly implemented to move to a prospective payment plan. The diagnosis-related group (DRG)-based case-mix payment system, with its superior efficiency and containment of costs, has garnered increased attention and it represents a promising alternative...
April 15, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29657030/rewiring-of-glutamine-metabolism-is-a-bioenergetic-adaptation-of-human-cells-with-mitochondrial-dna-mutations
#15
Qiuying Chen, Kathryne Kirk, Yevgeniya I Shurubor, Dazhi Zhao, Andrea J Arreguin, Ifrah Shahi, Federica Valsecchi, Guido Primiano, Elizabeth L Calder, Valerio Carelli, Travis T Denton, M Flint Beal, Steven S Gross, Giovanni Manfredi, Marilena D'Aurelio
Using molecular, biochemical, and untargeted stable isotope tracing approaches, we identify a previously unappreciated glutamine-derived α-ketoglutarate (αKG) energy-generating anaplerotic flux to be critical in mitochondrial DNA (mtDNA) mutant cells that harbor human disease-associated oxidative phosphorylation defects. Stimulating this flux with αKG supplementation enables the survival of diverse mtDNA mutant cells under otherwise lethal obligatory oxidative conditions. Strikingly, we demonstrate that when residual mitochondrial respiration in mtDNA mutant cells exceeds 45% of control levels, αKG oxidative flux prevails over reductive carboxylation...
April 9, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29656919/trends-and-gaps-in-awareness-of-direct-to-consumer-genetic-tests-from-2007-to-2014
#16
Nate C Apathy, Terri Menser, Lindsay M Keeran, Eric W Ford, Christopher A Harle, Timothy R Huerta
INTRODUCTION: Direct-to-consumer genetic tests for inherited disease risks have gained recent approvals from the Food and Drug Administration, and interest in these tests has continued to grow. Broad use of these tests coupled with planning and discussion with health providers regarding genetic risks and potential protective behavior changes have been proposed as preventive tools to reduce health disparities and improve equity in health outcomes. However, awareness of direct-to-consumer genetic testing has historically demonstrated differences by education, income, and race; these disparities could jeopardize potential benefits by limiting access and use...
April 12, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29653187/mid-cervical-spinal-cord-contusion-causes-robust-deficits-in-respiratory-parameters-and-pattern-variability
#17
Philippa M Warren, Cara Campanaro, Frank J Jacono, Warren J Alilain
Mid-cervical spinal cord contusion disrupts both the pathways and motoneurons vital to the activity of inspiratory muscles. The present study was designed to determine if a rat contusion model could result in a measurable deficit to both ventilatory and respiratory motor function under "normal" breathing conditions at acute to chronic stages post trauma. Through whole body plethysmography and electromyography we assessed respiratory output from three days to twelve weeks after a cervical level 3 (C3) contusion...
April 10, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29651344/etiologic-causes-and-epidemiological-characteristics-of-patients-with-intraocular-foreign-bodies-retrospective-analysis-of-1340-cases-over-ten-years
#18
Lin Li, Hai Lu, Kai Ma, Yun-Yun Li, Hai-Yan Wang, Ning-Pu Liu
Objective: Patients with intraocular foreign bodies were retrospectively analyzed. Population characteristics, pathogenic factors, and the outcomes during the past ten years were discussed. Design: Retrospective case series study. Method: Medical records of 1340 patients hospitalized in Beijing Tongren Hospital from January 1, 2004, to December 31, 2013, were collected. Results: Average age was 33.0 ± 13.8 (1-76) years old in 1340 patients...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29650377/articular-surgery-of-the-ischemic-hand-in-systemic-scleroderma-a-vascular-basis-for-arthrodesis-and-arthroplasty
#19
REVIEW
Charles P Melone, Erez Dayan
Hallmark deformities of systemic scleroderma are early onset and progressively disabling flexion contractures of the proximal interphalangeal (PIP) joints often in conjunction with extension or, less frequently, flexion contractures of the metacarpophalangeal (MCP) joints. Although surgical correction is generally recommended, a prevailing reluctance for operative treatment exists owing to the inherent ischemia of the disease with its potentially compromised healing capacity. Nonetheless, with recognition and preservation of the tenuous but well-defined and constant periarticular vascular networks of the PIP and MCP joints, articular reconstruction with uncomplicated wound healing can prove consistently successful for patients with scleroderma...
April 9, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29650224/examining-vehicle-operating-speeds-on-rural-two-lane-curves-using-naturalistic-driving-data
#20
Bo Wang, Shauna Hallmark, Peter Savolainen, Jing Dong
Horizontal curves have been shown to exhibit crash rates significantly higher than comparable tangent segments. Extensive research has investigated the causes of crashes on horizontal curves, particularly the curve navigation process and driver speed selection. Research in this area has generally been limited by the nature of the data, which is often inhibited by practical constraints as to the number of locations and drivers that can be observed. This study overcomes these hurdles through the use of naturalistic driving data, providing insights on how drivers navigate and react to curves on rural two-lane highways...
April 9, 2018: Accident; Analysis and Prevention
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