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https://www.readbyqxmd.com/read/29457243/raising-the-stakes-for-nondiscrimination-protections-in-the-aca
#1
Kristen Underhill
In the struggle over the durability of the Affordable Care Act, defenders of the ACA stand guard at many fronts. A major contribution of the ACA to nondiscrimination law, however, appears increasingly vulnerable. The ACA established significant new nondiscrimination protections for patients under section 1557 and its implementing regulations. Several of these regulations-including protections on the basis of gender identity and pregnancy termination-are now under reconsideration at the Department of Health and Human Services, after a nationwide injunction lasting almost a year...
January 2018: Hastings Center Report
https://www.readbyqxmd.com/read/29456519/why-don-t-you-go-to-bed-on-time-a-daily-diary-study-on-the-relationships-between-chronotype-self-control-resources-and-the-phenomenon-of-bedtime-procrastination
#2
Jana Kühnel, Christine J Syrek, Anne Dreher
Background: This daily diary study investigates the phenomenon of bedtime procrastination. Bedtime procrastination is defined as going to bed later than intended, without having external reasons for doing so. We highlight the role chronotype (interindividual differences in biological preferences for sleep-wake-times) plays for bedtime procrastination. Moreover, we challenge the view that bedtime procrastination is the result of a lack of self-regulatory resources by investigating momentary self-regulatory resources as a predictor of day-specific bedtime procrastination...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29456257/irc-10-216-in-3-d-morphology-of-a-tp-agb-star-envelope
#3
M Guélin, N A Patel, M Bremer, J Cernicharo, A Castro-Carrizo, J Pety, J P Fonfría, M Agúndez, M Santander-García, G Quintana-Lacaci, L Velilla Prieto, R Blundell, P Thaddeus
During their late pulsating phase, AGB stars expel most of their mass in the form of massive dusty envelopes, an event that largely controls the composition of interstellar matter. The envelopes, however, are distant and opaque to visible and NIR radiation: their structure remains poorly known and the mass-loss process poorly understood. Millimeter-wave interferometry, which combines the advantages of longer wavelength, high angular resolution and very high spectral resolution is the optimal investigative tool for this purpose...
February 2018: Astronomy and Astrophysics
https://www.readbyqxmd.com/read/29455440/computer-aided-solution-for-automatic-segmenting-and-measurements-of-blood-leucocytes-using-static-microscope-images
#4
Enas Abdulhay, Mazin Abed Mohammed, Dheyaa Ahmed Ibrahim, N Arunkumar, V Venkatraman
Blood leucocytes segmentation in medical images is viewed as difficult process due to the variability of blood cells concerning their shape and size and the difficulty towards determining location of Blood Leucocytes. Physical analysis of blood tests to recognize leukocytes is tedious, time-consuming and liable to error because of the various morphological components of the cells. Segmentation of medical imagery has been considered as a difficult task because of complexity of images, and also due to the non-availability of leucocytes models which entirely captures the probable shapes in each structures and also incorporate cell overlapping, the expansive variety of the blood cells concerning their shape and size, various elements influencing the outer appearance of the blood leucocytes, and low Static Microscope Image disparity from extra issues outcoming about because of noise...
February 17, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29454903/estrogen-receptor-alpha-isoforms-are-the-main-estrogen-receptors-expressed-in-non-small-cell-lung-carcinoma
#5
Vasiliki Pelekanou, Eleftheria Anastasiou, Efstathia Bakogeorgou, George Notas, Marilena Kampa, Rolando Garcia-Milian, Katerina Lavredaki, Eleni Moustou, Georgia Chinari, Petroula Arapantoni, Anthony O'Grady, Vassilios Georgoulias, Andreas Tsapis, Efstathios N Stathopoulos, Elias Castanas
The expression profile of estrogen receptors (ER) in Non-Small Cell Lung Carcinoma (NSCLC) remains contradictory. Here we investigated protein and transcriptome expression of ERα wild type and variants. Tissue Micro-Arrays of 200 cases of NSCLC (paired tumor/non-tumor) were assayed by immunohistochemistry using a panel of ERα antibodies targeting different epitopes (HC20, 6F11, 1D5, ERα36 and ERα17p). ERβ epitopes were also examined for comparison. In parallel we conducted a probe-set mapping (Affymetrix HGU133 plus 2 chip) meta-analysis of 12 NSCLC tumor public transcriptomic studies (1418 cases) and 39 NSCLC cell lines...
February 15, 2018: Steroids
https://www.readbyqxmd.com/read/29450399/functional-results-of-cataract-surgery-in-the-treatment-of-phacomorphic-glaucoma
#6
Andreea Moraru, Gabriela Pînzaru, Anca Moţoc, Dănuţ Costin
Purpose. Analysis of functional outcome and complications reported in patients diagnosed with phacomorphic glaucoma, in which phacoemulsification or extracapsular extraction of the lens was performed. Methods. The retrospective study included 38 eyes diagnosed with phacomorphic glaucoma. In 25 cases, group 1, the lens was removed by phacoemulsification and in 13 cases, group 2, by extracapsular extraction. Intraocular pressure, visual acuity, and anterior chamber depth were evaluated preoperative and postoperative...
July 2017: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29449849/comprehensive-cloning-of-prunus-mume-dormancy-associated-mads-box-genes-and-their-response-in-flower-bud-development-and-dormancy
#7
Kai Zhao, Yuzhen Zhou, Sagheer Ahmad, Zongda Xu, Yushu Li, Weiru Yang, Tangren Cheng, Jia Wang, Qixiang Zhang
Dormancy Associated MADS-box genes are SVP/MADs-box members and supposed to play crucial roles in plant dormancy of perennial species. In Prunus mume , PmDAM6 has been previously identified to induce plant dormancy. In the current study, six PmDAMs were cloned in P. mume and functionally analyzed in yeast and tobacco to detect the roles of the genes paralogous to PmDAM6 . The expression patterns together with sequence similarities indicate that PmDAMs are divided into two sub-clades within SVP group. Moreover, PmDAMs are verified to take part in the development of different plant organs, specifically the flower buds, in some intricate patterns...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29447760/climatic-controls-on-later-stone-age-human-adaptation-in-africa-s-southern-cape
#8
Brian M Chase, J Tyler Faith, Alex Mackay, Manuel Chevalier, Andrew S Carr, Arnoud Boom, Sophak Lim, Paula J Reimer
Africa's southern Cape is a key region for the evolution of our species, with early symbolic systems, marine faunal exploitation, and episodic production of microlithic stone tools taken as evidence for the appearance of distinctively complex human behavior. However, the temporally discontinuous nature of this evidence precludes ready assumptions of intrinsic adaptive benefit, and has encouraged diverse explanations for the occurrence of these behaviors, in terms of regional demographic, social and ecological conditions...
January 2018: Journal of Human Evolution
https://www.readbyqxmd.com/read/29446509/recovery-without-autonomy-progress-forward-or-more-of-the-same-for-mental-health-service-users
#9
Louise Byrne, Stephanie Schoeppe, Julie Bradshaw
In Western nations, the Recovery approach has become a widely accepted philosophy and treatment concept in mental health. Yet, community understanding of the Recovery approach remains largely unexplored. This study aimed to investigate (i) people's awareness of the principles underpinning the Recovery approach in mental health, and (ii) the treatment approaches people consider most important, and whether these align with the Recovery approach. To achieve these aims, a random sample of 1217 Australian adults participated in the National Social Survey (QSS) via telephone interview...
February 15, 2018: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29446315/left-ventricular-volume-analysis-as-a-basic-tool-to-describe-cardiac-function
#10
Peter L M Kerkhof, Tatiana Kuznetsova, Rania Ali, Neal Handly
The heart is often regarded as a compression pump. Therefore, determination of pressure and volume is essential for cardiac function analysis. Traditionally, ventricular performance was described in terms of the Starling curve, i.e., output related to input. This view is based on two variables (namely, stroke volume and end-diastolic volume), often studied in the isolated (i.e., denervated) heart, and has dominated the interpretation of cardiac mechanics over the last century. The ratio of the prevailing coordinates within that paradigm is termed ejection fraction (EF), which is the popular metric routinely used in the clinic...
March 1, 2018: Advances in Physiology Education
https://www.readbyqxmd.com/read/29445418/local-constructions-of-gender-based-violence-amongst-idps-in-northern-uganda-analysis-of-archival-data-collected-using-a-gender-and-age-segmented-participatory-ranking-methodology
#11
Alastair Ager, Carolyn Bancroft, Elizabeth Berger, Lindsay Stark
Background: Gender-based violence (GBV) is a significant problem in conflict-affected settings. Understanding local constructions of such violence is crucial to developing preventive and responsive interventions to address this issue. Methods: This study reports on a secondary analysis of archived data collected as part of formative qualitative work - using a group participatory ranking methodology (PRM) - informing research on the prevalence of GBV amongst IDPs in northern Uganda in 2006...
2018: Conflict and Health
https://www.readbyqxmd.com/read/29445346/psychological-shift-in-partners-of-people-with-multiple-sclerosis-who-undertake-lifestyle-modification-an-interpretive-phenomenological-study
#12
Sandra L Neate, Keryn L Taylor, George A Jelinek, Alysha M De Livera, Chelsea R Brown, Tracey J Weiland
Introduction: Being in an intimate relationship with a person with multiple sclerosis (MS) may have a substantial impact on the partner's quality of life. Existing research has largely focused on negative impacts of MS for both people with MS (PwMS) and their partners and has sampled the population of partners of PwMS who have primarily adopted standard medical management only. Modifiable lifestyle factors have become increasingly recognized in the management of MS symptoms and disease progression. For partners of PwMS who have undertaken lifestyle modification as an additional strategy to minimize disease progression, the impacts, both positive and negative remain unexplored...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29445297/managing-severe-pain-and-abuse-potential-the-potential-impact-of-a-new-abuse-deterrent-formulation-oxycodone-naltrexone-extended-release-product
#13
REVIEW
Joseph V Pergolizzi, Robert Taylor, Jo Ann LeQuang, Robert B Raffa
Proper management of severe pain represents one of the most challenging clinical dilemmas. Two equally important goals must be attained: the humanitarian/medical goal to relieve suffering and the societal/legal goal to not contribute to the drug abuse problem. This is an age-old problem, and the prevailing emphasis placed on one or the other goal has resulted in pendulum swings that have resulted in either undertreatment of pain or the current epidemic of misuse and abuse. In an effort to provide efficacious strong pain relievers (opioids) that are more difficult to abuse by the most dangerous routes of administration, pharmaceutical companies are developing products in which the opioid is manufactured in a formulation that is designed to be tamper resistant...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29445275/burden-of-copd-in-nepal
#14
Tara Ballav Adhikari, Dinesh Neupane, Per Kallestrup
Background: COPD is a globally significant public health problem and is the second leading cause of mortality. This study presents the health burden of COPD in Nepal using the Global Burden of Disease (GBD) study 2016 dataset. Methods: This study used the data from the GBD repository presenting morbidity and mortality attributed to COPD, by sex and age. In GBD 2016, due to a lack of the primary source of data in Nepal, estimations on morbidity and mortality of COPD were based on its predictive covariates...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29443976/how-many-human-proteoforms-are-there
#15
Ruedi Aebersold, Jeffrey N Agar, I Jonathan Amster, Mark S Baker, Carolyn R Bertozzi, Emily S Boja, Catherine E Costello, Benjamin F Cravatt, Catherine Fenselau, Benjamin A Garcia, Ying Ge, Jeremy Gunawardena, Ronald C Hendrickson, Paul J Hergenrother, Christian G Huber, Alexander R Ivanov, Ole N Jensen, Michael C Jewett, Neil L Kelleher, Laura L Kiessling, Nevan J Krogan, Martin R Larsen, Joseph A Loo, Rachel R Ogorzalek Loo, Emma Lundberg, Michael J MacCoss, Parag Mallick, Vamsi K Mootha, Milan Mrksich, Tom W Muir, Steven M Patrie, James J Pesavento, Sharon J Pitteri, Henry Rodriguez, Alan Saghatelian, Wendy Sandoval, Hartmut Schlüter, Salvatore Sechi, Sarah A Slavoff, Lloyd M Smith, Michael P Snyder, Paul M Thomas, Mathias Uhlén, Jennifer E Van Eyk, Marc Vidal, David R Walt, Forest M White, Evan R Williams, Therese Wohlschlager, Vicki H Wysocki, Nathan A Yates, Nicolas L Young, Bing Zhang
Despite decades of accumulated knowledge about proteins and their post-translational modifications (PTMs), numerous questions remain regarding their molecular composition and biological function. One of the most fundamental queries is the extent to which the combinations of DNA-, RNA- and PTM-level variations explode the complexity of the human proteome. Here, we outline what we know from current databases and measurement strategies including mass spectrometry-based proteomics. In doing so, we examine prevailing notions about the number of modifications displayed on human proteins and how they combine to generate the protein diversity underlying health and disease...
February 14, 2018: Nature Chemical Biology
https://www.readbyqxmd.com/read/29442374/eosinophils-are-not-essential-for-maintenance-of-murine-plasma-cells-in-the-bone-marrow
#16
Konrad Haberland, Jochen A Ackermann, Natacha Ipseiz, Stephan Culemann, Katharina Pracht, Matthias Englbrecht, Hans-Martin Jäck, Georg Schett, Wolfgang Schuh, Gerhard Krönke
Eosinophils were reported to serve as an essential component of the plasma cell niche within the bone marrow. As the potential contribution of eosinophils to humoral immunity has remained incompletely understood, we aimed to further characterize their role during antibody responses and to additionally investigate their role in autoimmune disease. Contrary to our expectations and the currently prevailing paradigm, we found that eosinophils are fully dispensable for the survival of murine bone marrow plasma cells and accordingly do not contribute to antibody production and autoantibody-mediated disease...
February 14, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29442171/the-role-of-saccharomyces-cerevisiae-in-stabilizing-emulsions-of-hexadecane-in-aqueous-media
#17
Aureliano Agostinho Dias Meirelles, Rosiane Lopes da Cunha, Andreas Karoly Gombert
During downstream operations involved in the purification of hydrophobic biofuels produced by microorganisms, undesired stable emulsions may be formed. Understanding the mechanisms behind this stability is a pre-requisite for designing cost-effective strategies to break these emulsions. In this work, we aimed at increasing our knowledge on the mechanisms responsible for stabilizing yeast-containing oil-in-water emulsions. For this purpose, emulsions containing hexadecane and different yeast-based aqueous phases were prepared and analyzed for phase separation, surface charge density, particle size, and rheology...
February 14, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29441704/chemoselective-z-olefin-synthesis-via-rh-catalyzed-formate-mediated-1-6-reduction
#18
Raphael Dada, Zhongyu Wei, Ruohua Gui, Rylan J Lundgren
Z-olefins are important functional units in synthetic chemistry; thus their preparation has received considerable attention. Many prevailing methods for cis-olefination are complicated by the presence of multiple unsaturated units or electrophilic functional groups. In this study, Z-olefin products are delivered via selective reduction of activated dienes using formic acid. The reaction proceeds with high regio- and stereoselectivity (typically >90:10 and >95:5 respectively) and preserves other alkenyl, alkynyl, protic and electrophilic groups...
February 13, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29433919/gene-expression-dominance-in-allopolyploids-hypotheses-and-models
#19
REVIEW
Samuel Bottani, Nicolae Radu Zabet, Jonathan F Wendel, Reiner A Veitia
The classical example of nonadditive contributions of the two parents to allopolyploids is nucleolar dominance, which entails silencing of one parental set of ribosomal RNA genes. This has been observed for many other loci. The prevailing explanation for this genome-wide expression disparity is that the two merged genomes differ in their transposable element (TE) complement and in their level of TE-mediated repression of gene expression. Alternatively, and not exclusively, gene expression dominance may arise from mismatches between trans effectors and their targets...
February 9, 2018: Trends in Plant Science
https://www.readbyqxmd.com/read/29430591/shifting-to-value-based-principles-in-sickness-insurance-challenges-in-changing-roles-and-culture
#20
Christian Ståhl, Frieda Andersson
Purpose Management principles in insurance agencies influence how benefits are administered, and how return to work processes for clients are managed and supported. This study analyses a change in managerial principles within the Swedish Sickness Insurance Agency, and how this has influenced the role of insurance officials in relation to discretion and accountability, and their relationship to clients. Methods The study is based on a qualitative approach comprising 57 interviews with officials and managers in four insurance offices...
February 12, 2018: Journal of Occupational Rehabilitation
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