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https://www.readbyqxmd.com/read/28551914/-notes-assisted-endolumenal-rectal-resection-and-specimen-extraction-without-rectal-stump-opening-our-experience-with-this-novel-technique-in-a-porcine-model
#1
Anton Kvasha, Eyal Rosenthal, Muhammad Khalifa, Igor Waksman
INTRODUCTION: Laparoscopic surgery has long been used for colon and rectal resection, and the laparoscopic-assisted approach has prevailed in surgical practice. While this technique includes the fashioning of an intra-corporeal anastomosis, it still requires an abdominal incision for specimen extraction. Elimination of the abdominal incision and its potential complications has been the motivation for the development of natural orifice specimen extraction (NOSE) techniques. Many of these techniques make use of an open rectal stump, which poses as a potential for intra-abdominal contamination...
May 2017: Harefuah
https://www.readbyqxmd.com/read/28551493/residential-greenness-and-adiposity-findings-from-the-uk-biobank
#2
Chinmoy Sarkar
BACKGROUND: With the rapid urbanization and prevailing obesity pandemic, the role of residential green exposures in obesity prevention has gained renewed focus. The study investigated the effects of residential green exposures on adiposity using a large and diverse population sample drawn from the UK Biobank. MATERIALS AND METHODS: This was a population based cross-sectional study of 333,183 participants aged 38-73years with individual-level data on residential greenness and built environment exposures...
May 25, 2017: Environment International
https://www.readbyqxmd.com/read/28551051/time-to-think-outside-the-box-prompt-individualised-safe-management-pr-i-s-m-should-prevail-in-patients-with-multiple-injuries
#3
EDITORIAL
P V Giannoudis, Vasileios P Giannoudis, Daniel S Horwitz
No abstract text is available yet for this article.
May 19, 2017: Injury
https://www.readbyqxmd.com/read/28550689/a-diagnostic-program-of-vascular-tumor-and-vascular-malformations-in-children-according-to-modern-classification
#4
Iryna Benzar
The aim of the study was to analyze the cohort of inpatient children with vascular anomalies according to the globally accepted classification introduced by the ISSVA. METHODS: The study included 205 inpatient children within the time period of the years 2010-2015. Types of vascular anomalies (VAs), age of patients, diagnostic procedures, and anatomical localization of VAs were analyzed. RESULTS: 65 patients of first year of life had vascular tumors, with prevalence of infantile hemangiomas (IHs) in 57 (87...
May 26, 2017: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/28550516/mapping-the-spatio-temporal-distribution-of-key-vegetation-cover-properties-in-lowland-river-reaches-using-digital-photography
#5
Veerle Verschoren, Jonas Schoelynck, Kerst Buis, Fleur Visser, Patrick Meire, Stijn Temmerman
The presence of vegetation in stream ecosystems is highly dynamic in both space and time. A digital photography technique is developed to map aquatic vegetation cover at species level, which has a very high spatial and a flexible temporal resolution. A digital single-lens reflex (DSLR) camera mounted on a handheld telescopic pole is used. The low-altitude (5 m) orthogonal aerial images have a low spectral resolution (red-green-blue), high spatial resolution (∼1.9 pixels cm(-2), ∼1.3 cm length) and flexible temporal resolution (monthly)...
June 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28550263/microglial-and-neuronal-tdp-43-pathology-in-anti-iglon5-related-tauopathy
#6
Annachiara Cagnin, Sara Mariotto, Michele Fiorini, Marina Gaule, Nicola Bonetto, Matteo Tagliapietra, Emanuele Buratti, Gianluigi Zanusso, Sergio Ferrari, Salvatore Monaco
A novel neuronal tauopathy, mainly confined to hypothalamus and brainstem tegmentum, has recently been reported in patients with autoantibodies to the neuronal cell-adhesion molecule IgLON5. We describe a patient with anti-IgLON5 syndrome, who presented with dysautonomia and sleep disorder, followed by subacute dementia. Postmortem brain examination disclosed neuronal tau pathology prevailing in the hippocampus, amygdala, and locus coeruleus, in addition to microglial/neuronal TDP-43 pathology, with overexpression of aberrantly phosphorylated forms and neurotoxic truncated fragments, in basal ganglia, nucleus basalis, thalamus, and midbrain...
May 26, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28549279/control-adjustments-in-speaking-electrophysiology-of-the-gratton-effect-in-picture-naming
#7
Natalia Shitova, Ardi Roelofs, Herbert Schriefers, Marcel Bastiaansen, Jan-Mathijs Schoffelen
Accumulating evidence suggests that spoken word production requires different amounts of top-down control depending on the prevailing circumstances. For example, during Stroop-like tasks, the interference in response time (RT) is typically larger following congruent trials than following incongruent trials. This effect is called the Gratton effect, and has been taken to reflect top-down control adjustments based on the previous trial type. Such control adjustments have been studied extensively in Stroop and Eriksen flanker tasks (mostly using manual responses), but not in the picture-word interference (PWI) task, which is a workhorse of language production research...
April 29, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28549109/il-18-cleavage-triggers-cardiac-inflammation-and-fibrosis-upon-%C3%AE-adrenergic-insult
#8
Han Xiao, Hao Li, Jing-Jing Wang, Jian-Shu Zhang, Jing Shen, Xiang-Bo An, Cong-Cong Zhang, Ji-Min Wu, Yao Song, Xin-Yu Wang, Hai-Yi Yu, Xiang-Ning Deng, Zi-Jian Li, Ming Xu, Zhi-Zhen Lu, Jie Du, Wei Gao, Ai-Hua Zhang, Yue Feng, You-Yi Zhang
Aims: Rapid over-activation of β-adrenergic receptor (β-AR) upon stress leads to cardiac inflammation, a prevailing factor that underlies heart injury. However, mechanisms by which acute β-AR stimulation induce cardiac inflammation still remain unknown. Here, we set out to identify the crucial role of inflammasome/interleukin (IL)-18 in initiating and maintaining cardiac inflammatory cascades upon β-AR insult. Methods and results: Male C57BL/6 mice were injected with a single dose of β-AR agonist, isoproterenol (ISO, 5 mg/kg body weight) or saline subcutaneously...
May 26, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28548661/co-evolution-with-staphylococcus-aureus-leads-to-lipopolysaccharide-alterations-in-pseudomonas-aeruginosa
#9
Mikael Tognon, Thilo Köhler, Bartosz G Gdaniec, Youai Hao, Joseph S Lam, Marie Beaume, Alexandre Luscher, Angus Buckling, Christian van Delden
Detrimental and beneficial interactions between co-colonizing bacteria may influence the course of infections. In cystic fibrosis (CF) airways, Staphylococcus aureus prevails in childhood, whereas Pseudomonas aeruginosa progressively predominates thereafter. While a range of interactions has been identified, it is unclear if these represent specific adaptations or correlated responses to other aspects of the environment. Here, we investigate how P. aeruginosa adapts to S. aureus by evolving P. aeruginosa in the presence and absence of S...
May 26, 2017: ISME Journal
https://www.readbyqxmd.com/read/28548487/the-challenge-of-overcoming-antibiotic-resistance-an-adjuvant-approach
#10
Roberta J Melander, Christian Melander
Antibiotic resistance is one of the greatest current threats to human health, and without significant action we face the chilling prospect of a world without effective antibiotics. Although continued effort toward the development of new antibiotics, particularly those with novel mechanisms of action, remains crucial, this alone probably will not be enough to prevail, and it is imperative that additional approaches are also explored. One such approach is the identification of adjuvants that augment the activity of current antibiotics...
May 26, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28547292/physiological-implications-of-ocean-acidification-for-marine-fish-emerging-patterns-and-new-insights
#11
REVIEW
Andrew J Esbaugh
Ocean acidification (OA) is an impending environmental stress facing all marine life, and as such has been a topic of intense research interest in recent years. Numerous detrimental effects have been documented in marine fish, ranging from reduced mortality to neurosensory impairment, and the prevailing opinions state that these effects are largely the downstream consequences of altered blood carbon dioxide chemistry caused by respiratory acid-base disturbances. While the respiratory acid-base disturbances are consistent responses to OA across tested fish species, it is becoming increasingly clear that there is wide variability in the degree of downstream impairments between species...
May 25, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28546560/potential-decline-in-carbon-carrying-capacity-under-projected-climate-wildfire-interactions-in-the-sierra-nevada
#12
Shuang Liang, Matthew D Hurteau, Anthony LeRoy Westerling
Ecosystem carbon carrying capacity (CCC) is determined by prevailing climate and natural disturbance regimes, conditions that are projected to change significantly. The interaction of changing climate and its effects on disturbance regimes is expected to affect forest regeneration and growth, which may diminish forest carbon (C) stocks and uptake. We modeled landscape C dynamics over 590 years along the latitudinal gradient of the U.S. Sierra Nevada Mountains under climate and area burned by large wildfires projected by late 21(st) century...
May 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28546210/release-of-mineral-bound-water-prior-to-subduction-tied-to-shallow-seismogenic-slip-off-sumatra
#13
Andre Hüpers, Marta E Torres, Satoko Owari, Lisa C McNeill, Brandon Dugan, Timothy J Henstock, Kitty L Milliken, Katerina E Petronotis, Jan Backman, Sylvain Bourlange, Farid Chemale, Wenhuang Chen, Tobias A Colson, Marina C G Frederik, Gilles Guèrin, Mari Hamahashi, Brian M House, Tamara N Jeppson, Sarah Kachovich, Abby R Kenigsberg, Mebae Kuranaga, Steffen Kutterolf, Freya L Mitchison, Hideki Mukoyoshi, Nisha Nair, Kevin T Pickering, Hugo F A Pouderoux, Yehua Shan, Insun Song, Paola Vannucchi, Peter J Vrolijk, Tao Yang, Xixi Zhao
Plate-boundary fault rupture during the 2004 Sumatra-Andaman subduction earthquake extended closer to the trench than expected, increasing earthquake and tsunami size. International Ocean Discovery Program Expedition 362 sampled incoming sediments offshore northern Sumatra, revealing recent release of fresh water within the deep sediments. Thermal modeling links this freshening to amorphous silica dehydration driven by rapid burial-induced temperature increases in the past 9 million years. Complete dehydration of silicates is expected before plate subduction, contrasting with prevailing models for subduction seismogenesis calling for fluid production during subduction...
May 26, 2017: Science
https://www.readbyqxmd.com/read/28545985/reproductive-dysfunction-in-females-of-endangered-golden-mahseer-tor-putitora-in-captivity
#14
M S Akhtar, A Ciji, D Sarma, M Rajesh, B S Kamalam, P Sharma, A K Singh
The present study was undertaken to gain insight on the physiological basis underlying the constraints in attaining maturity of endangered golden mahseer (Tor putitora) in captivity. Selected hormone levels and stress biomarkers were analysed in wild and captive reared brooders to address the above objectives. As compared to their captive counterparts, plasma 17β-estradiol was significantly (p<0.05) higher in wild caught females. A concurrent trend was observed for plasma vitellogenin, aromatase, 17α, 20β-dihydroxy progesterone (17α, 20β DHP), luteinizing hormone (LH) and11-ketotestosterone (11-KT) indicating a weak hormone response in captive females that potentially hindered maturity...
May 18, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28545440/comprehensive-taxonomy-and-worldwide-trends-in-pharmaceutical-policies-in-relation-to-country-income-status
#15
N Maniadakis, G Kourlaba, J Shen, A Holtorf
BACKGROUND: Rapidly evolving socioeconomic and technological trends make it challenging to improve access, effectiveness and efficiency in the use of pharmaceuticals. This paper identifies and systematically classifies the prevailing pharmaceutical policies worldwide in relation to a country's income status. METHODS: A literature search was undertaken to identify and taxonomize prevailing policies worldwide. Countries that apply those policies and those that do not were then grouped by income status...
May 25, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28544990/degradation-of-mecoprop-in-polluted-landfill-leachate-and-waste-water-in-a-moving-bed-biofilm-reactor
#16
Mònica Escolà Casas, Tue Kjærgaard Nielsen, Witold Kot, Lars Hestbjerg Hansen, Anders Johansen, Kai Bester
Mecoprop is a common pollutant in effluent-, storm- and groundwater as well as in leachates from derelict dumpsites. Thus, bioremediation approaches may be considered. We conducted batch experiments with moving bed biofilm (MBBR)-carriers to understand the degradation of mecoprop. As a model, the carriers were incubated in effluent from a conventional wastewater treatment plant which was spiked to 10, 50 and 100 μg L(-1) mecoprop. Co-metabolic processes as well as mineralization were studied. Initial mecoprop concentration and mecoprop degradation impacted the microbial communities...
May 17, 2017: Water Research
https://www.readbyqxmd.com/read/28542657/-polygraphy-in-hospitalized-children-under-3-months
#17
Daniel Zenteno, Iván Rodríguez-Núñez, Ignacio Molina, Rubén Peña, Carla Rivas, Jaime Tapia, Pablo Brockmann
Apnea and apparently lethal events have great etiological diversity thus complementary tests may help diagnosis. The aim of this study was to describe the results of polygraph studies of children under 3 months hospitalized with suspected apnea. PATIENTS AND METHODS: Retrospective case series. Children under 3 months with suspected apnea were considered and in whom a polygraphy (PG) was performed during hospitalization. General data, the apnea/hypopnea index (AHI), index of central. apnea, obstructive apnea index, average and minimum saturation were recorded...
April 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28542503/biofilm-microenvironment-induces-a-widespread-adaptive-amino-acid-fermentation-pathway-conferring-strong-fitness-advantage-in-escherichia-coli
#18
Sylvie Létoffé, Sabina Chalabaev, José Dugay, Franziska Stressmann, Bianca Audrain, Jean-Charles Portais, Fabien Letisse, Jean-Marc Ghigo
Bacterial metabolism has been studied primarily in liquid cultures, and exploration of other natural growth conditions may reveal new aspects of bacterial biology. Here, we investigate metabolic changes occurring when Escherichia coli grows as surface-attached biofilms, a common but still poorly characterized bacterial lifestyle. We show that E. coli adapts to hypoxic conditions prevailing within biofilms by reducing the amino acid threonine into 1-propanol, an important industrial commodity not known to be naturally produced by Enterobacteriaceae...
May 19, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28541927/comparison-of-nitrogen-vacancy-complexes-in-diamond-and-cubic-sic-dose-dependencies-and-spin-hamiltonian-parameters
#19
Taras Leonidovych Petrenko, V Bryksa
At present nitrogen-vacancy (NV) complex in diamond is the most promising defect for application in the area of quantum computing. This provides a stimulus for extensive search of another defects in semiconductors with similar properties. Recently it was shown that N$_{C}$V$_{Si}$ defect complex in SiC is perspective for this goal as well. In the present work we perform comparative \textit{ab initio} studies of NV complexes in diamond and 3\textit{C}-SiC. We focus both on radiospectroscopic characterization of these defects and on calculation of equilibrium concentration of complexes in irradiated crystals...
May 25, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28541812/engineering-humanized-antibody-framework-sequences-for-optimal-site-specific-conjugation-of-cytotoxins
#20
Jared L Spidel, Earl F Albone, Xin Cheng, Benjamin Vaessen, Sara Jacob, Andrew Z Milinichik, Arielle Verdi, J Bradford Kline, Luigi Grasso
The prevailing techniques used to generate antibody-drug conjugates (ADCs) involve random conjugation of the linker-drug to multiple lysines or cysteines in the antibody. Engineering natural and non-natural amino acids into an antibody has been demonstrated to be an effective strategy to produce homogeneous ADC products with defined drug-to-antibody ratios. We recently reported an efficient residue-specific conjugation technology (RESPECT) where thiol-reactive payloads can be efficiently conjugated to a native unpaired cysteine in position 80 (C80) of rabbit light chains...
May 25, 2017: MAbs
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