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https://www.readbyqxmd.com/read/29340078/differential-gene-expression-profiles-between-two-subtypes-of-ischemic-stroke-with-blood-stasis-syndromes
#1
Tian-Long Liu, Min-Na Liu, Xin-Liang Xu, Wen-Xing Liu, Pei-Jin Shang, Xiao-Hu Zhai, Hang Xu, Yi Ding, Yu-Wen Li, Ai-Dong Wen
Ischemic stroke is a cerebrovascular thrombotic disease with high morbidity and mortality. Qi deficiency blood stasis (QDBS) and Yin deficiency blood stasis (YDBS) are the two major subtypes of ischemic stroke according to the theories of traditional Chinese medicine. This study was conducted to distinguish these two syndromes at transcriptomics level and explore the underlying mechanisms. Male rats were randomly divided into three groups: sham group, QDBS/MCAO group and YDBS/MCAO group. Morphological changes were assessed after 24 h of reperfusion...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29336358/risk-factors-regional-disparity-and-trends-of-ischemic-stroke-etiologic-subtypes
#2
EDITORIAL
Dan-Yang Tian, Dong-Sheng Fan
No abstract text is available yet for this article.
January 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29335336/periodontal-disease-regular-dental-care-use-and-incident-ischemic-stroke
#3
Souvik Sen, Lauren D Giamberardino, Kevin Moss, Thiago Morelli, Wayne D Rosamond, Rebecca F Gottesman, James Beck, Steven Offenbacher
BACKGROUND AND PURPOSE: Periodontal disease is independently associated with cardiovascular disease. Identification of periodontal disease as a risk factor for incident ischemic stroke raises the possibility that regular dental care utilization may reduce the stroke risk. METHODS: In the ARIC (Atherosclerosis Risk in Communities) study, pattern of dental visits were classified as regular or episodic dental care users. In the ancillary dental ARIC study, selected subjects from ARIC underwent fullmouth periodontal measurements collected at 6 sites per tooth and classified into 7 periodontal profile classes (PPCs)...
January 15, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29330661/adipose-tissue-fatty-acids-present-in-dairy-fat-and-risk-of-stroke-the-danish-diet-cancer-and-health-cohort
#4
Anne Sofie Dam Laursen, Christina Catherine Dahm, Søren Paaske Johnsen, Erik Berg Schmidt, Kim Overvad, Marianne Uhre Jakobsen
PURPOSE: The role of dairy fat for the risk of stroke is not yet clear. Adipose tissue reflects long-term fatty acid intake and metabolism. We, therefore, investigated associations for percentages of adipose tissue fatty acids, for which dairy products are a major source (12:0, 14:0, 14:1 cis-9, 15:0, 17:0, 18:1 trans-11 and 18:2 cis-9, trans-11), with incident total stroke and stroke subtypes. METHODS: We conducted a case-cohort study within the Danish Diet, Cancer and Health cohort, including all incident stroke cases (n = 2108) and a random sample of the total cohort (n = 3186)...
January 12, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29330335/fabry-disease-prevalence-of-affected-males-and-heterozygotes-with-pathogenic-gla-mutations-identified-by-screening-renal-cardiac-and-stroke-clinics-1995-2017
#5
Dana Doheny, Ram Srinivasan, Silvere Pagant, Brenden Chen, Makiko Yasuda, Robert J Desnick
BACKGROUND: Fabry Disease (FD), an X linked lysosomal storage disease due to pathogenic α-galactosidase A (GLA) mutations, results in two major subtypes, the early-onset Type 1 'Classic' and the Type 2 'Later-Onset' phenotypes. To identify previously unrecognised patients, investigators screened cardiac, renal and stroke clinics by enzyme assays. However, some screening studies did not perform confirmatory GLA mutation analyses, and many included recently recognised 'benign/likely-benign' variants, thereby inflating prevalence estimates...
January 12, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29330257/hemoglobin-albuminuria-and-kidney-function-in-cardiovascular-risk-the-aric-atherosclerosis-risk-in-communities-study
#6
Junichi Ishigami, Morgan E Grams, Rakhi P Naik, Melissa C Caughey, Laura R Loehr, Shinichi Uchida, Josef Coresh, Kunihiro Matsushita
BACKGROUND: Reduced estimated glomerular filtration rate (eGFR) and elevated urinary albumin-to-creatinine ratio (ACR) individually increase risk of cardiovascular disease (CVD). We hypothesized that these associations are stronger among people with abnormal (both low and high) hemoglobin levels. METHODS AND RESULTS: Using 5801 participants with available hemoglobin measures of the ARIC (Atherosclerosis Risk in Community) study in 1996-1998, we explored the cross-sectional association of eGFR and ACR with hemoglobin levels and their longitudinal associations with CVD (heart failure, coronary heart disease, and stroke) risk through 2013...
January 12, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29324452/adjudication-of-transient-ischemic-attack-and-stroke-in-the-multi-ethnic-study-of-atherosclerosis
#7
W T Longstreth, Natalie C Gasca, Rebecca F Gottesman, John B Pearce, Ralph L Sacco
BACKGROUND: To describe adjudication of transient ischemic attack (TIA) and stroke in an observational study. METHODS: We detail the process used to adjudicate TIA and stroke in the Multi-Ethnic Study of Atherosclerosis (MESA), a large longitudinal cohort study. Two of three vascular neurologists adjudicated each event using specific protocols. We examined the initial agreement, effect of imaging on diagnosis of TIA versus ischemic stroke, and effect of strict and less strict criteria on the number of ischemic stroke subtypes classified as undetermined...
January 11, 2018: Neuroepidemiology
https://www.readbyqxmd.com/read/29310988/an-updated-diagnostic-approach-to-subtype-definition-of-vascular-parkinsonism-recommendations-from-an-expert-working-group
#8
REVIEW
Ivan Rektor, Nicolaas I Bohnen, Amos D Korczyn, Viktoria Gryb, Hrishikesh Kumar, Milica G Kramberger, Frank-Erik de Leeuw, Zvezdan Pirtošek, Irena Rektorová, Ilana Schlesinger, Jaroslaw Slawek, Peter Valkovič, Branislav Veselý
This expert working group report proposes an updated approach to subtype definition of vascular parkinsonism (VaP) based on a review of the existing literature. The persistent lack of consensus on clear terminology and inconsistent conceptual definition of VaP formed the impetus for the current expert recommendation report. The updated diagnostic approach intends to provide a comprehensive tool for clinical practice. The preamble for this initiative is that VaP can be diagnosed in individual patients with possible prognostic and therapeutic consequences and therefore should be recognized as a clinical entity...
December 29, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29291174/clinical-study-to-assess-the-outcome-in-surgically-managed-patients-of-spontaneous-intracerebral-hemorrhage
#9
Yashwanth S Sandeep, M Raja Guru, Ranjan Kumar Jena, Veldurti Ananta Kiran Kumar, Amit Agrawal
Introduction: Spontaneous intracerebral hemorrhage (SICH) subtype of stroke is characterized by bleeding into brain parenchyma which is not accompanied by trauma. Emergency surgical evacuation of large size SICH increases the chances of survival but does not help in functional recovery of the patients. The present study was conducted to assess the outcome of surgical management in patients with SICH. Materials and Methods: All patients who were diagnosed with SICH and underwent surgical evacuation of the hematoma included in the study...
October 2017: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/29284569/epidemiology-of-stroke-in-costa-rica-a-7-year-hospital-based-acute-stroke-registry-of-1319-consecutive-patients
#10
Gabriel Torrealba-Acosta, Kenneth Carazo-Céspedes, Sy Han Chiou, Anthony Terrence O'Brien, Huberth Fernández-Morales
BACKGROUND: Limited data on stroke exist for Costa Rica. Therefore, we created a stroke registry out of patients with stroke seen in the Acute Stroke Unit of the Hospital Calderon Guardia. METHODS: We analyzed 1319 patients enrolled over a 7-year period, which incorporated demographic, clinical, laboratory, and neuroimaging data. RESULTS: The mean age of patients with stroke was 68.0 ± 15.5 years. Seven hundred twenty-five were men and the age range was 13-104 years...
December 25, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29273595/promis-gh-patient-reported-outcomes-measurement-information-system-global-health-scale-in-stroke-a-validation-study
#11
Irene L Katzan, Brittany Lapin
BACKGROUND AND PURPOSE: The International Consortium for Health Outcomes Measurement recently included the 10-item PROMIS GH (Patient-Reported Outcomes Measurement Information System Global Health) scale as part of their recommended Standard Set of Stroke Outcome Measures. Before collection of PROMIS GH is broadly implemented, it is necessary to assess its performance in the stroke population. The objective of this study was to evaluate the psychometric properties of PROMIS GH in patients with ischemic stroke and intracerebral hemorrhage...
January 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29250322/rehabilitation-following-hemorrhagic-stroke-building-the-case-for-stroke-subtype-specific-recovery-therapies
#12
REVIEW
Tomoko Kitago, Rajiv R Ratan
Intracerebral hemorrhage (ICH), a form of brain bleeding and minor subtype of stroke, leads to significant mortality and long-term disability. There are currently no validated approaches to promote functional recovery after ICH. Research in stroke recovery and rehabilitation has largely focused on ischemic stroke, but given the stark differences in the pathophysiology between ischemic and hemorrhagic stroke, it is possible that strategies to rehabilitate the brain in distinct stroke subtypes will be different...
2017: F1000Research
https://www.readbyqxmd.com/read/29246963/associations-of-lipoprotein-a-levels-with-incident-atrial-fibrillation-and-ischemic-stroke-the-aric-atherosclerosis-risk-in-communities-study
#13
Konstantinos N Aronis, Di Zhao, Ron C Hoogeveen, Alvaro Alonso, Christie M Ballantyne, Eliseo Guallar, Steven R Jones, Seth S Martin, Saman Nazarian, Brian T Steffen, Salim S Virani, Erin D Michos
BACKGROUND: Lipoprotein(a) (Lp[a]) is proatherosclerotic and prothrombotic, causally related to coronary disease, and associated with other cardiovascular diseases. The association of Lp(a) with incident atrial fibrillation (AF) and with ischemic stroke among individuals with AF remains to be elucidated. METHODS AND RESULTS: In the community-based ARIC (Atherosclerosis Risk in Communities) study cohort, Lp(a) levels were measured by a Denka Seiken assay at visit 4 (1996-1998)...
December 15, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29246631/assessment-of-percheron-infarction-in-images-and-clinical-findings
#14
Zhihua Xu, Lingling Sun, Yang Duan, Jinghua Zhang, Mengzhi Zhang, Xiaonan Cai
OBJECTIVE: To assess the imaging and clinical features of patients with an artery of Percheron infarction comprehensively. METHODS: Of 6539 patients with a first-ever stroke, 18 patients with a Percheron infarction were enrolled, and their images and clinical data were retrospectively investigated. RESULTS: All patients underwent neurological intensive care unit (NICU) management. The initial symptom of a Percheron infarction included dizziness, transient blurred vision, double vision, barylalia, cerebellar ataxia, drowsiness, and a coma...
December 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29246620/discrepant-relationships-between-admission-blood-pressure-and-mortality-in-different-stroke-subtypes
#15
Yuanyuan Liu, Yide Yang, Haiqiang Jin, Chenghe Fan, Pu Lv, Wei Sun, Qing Peng, Mingming Zhao, David K Jin, Jiguang Wang, Lawrence K S Wong, Craig S Anderson, Lemin Zheng, Yining Huang
The relationship between blood pressure(BP) and clinical outcome in patients with acute stroke is still controversial. The present study aimed to elucidate the impact of admission blood pressure on mortality in patients with acute stroke of different subtypes. Data were from ChinaQUEST (QUality Evaluation of Stroke Care and Treatment), a multicenter, prospective hospital registry study in 37 cities across China. A total of 6427 patients were admitted within 24h of onset and after following up for 12months, 5501 were included in the final analysis...
December 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29246615/impact-of-anaemia-on-acute-stroke-outcomes-depends-on-the-type-of-anaemia-evidence-from-a-uk-stroke-register
#16
Raphae S Barlas, Stephen J McCall, Joao H Bettencourt-Silva, Allan B Clark, Kristian M Bowles, Anthony K Metcalf, Mamas A Mamas, John F Potter, Phyo K Myint
BACKGROUND: Previous research has demonstrated an association between anaemia and poor outcomes in acute stroke. This study aimed to assess the impact of anaemia on stroke by anaemia subtype. METHODS: Data from a prospective UK Regional Stroke Register were used to assess the association between hypochromic microcytic and normochromic normocytic anaemia on inpatient-mortality, length of stay (LOS) and discharge modified Rankin scale (mRS). Analysis was stratified by stroke subtypes and multivariable logistic regression, adjusting for potential confounders, was used to quantify this association...
December 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29245967/genetic-predisposition-to-ischaemic-stroke-by-rage-and-hmgb1-gene-variants-in-chinese-han-population
#17
You Li, Jing Zhu, Linfa Chen, Weidong Hu, Mengxu Wang, Shengnan Li, Xuefeng Gu, Hua Tao, Bin Zhao, Guoda Ma, Keshen Li
Emerging evidence suggests that the multiligand receptor for advanced glycation end products (RAGE) and its ligand high mobility group box 1 protein (HMGB1) contribute to the pathophysiology of ischaemic stroke (IS). The present study aimed to investigate the association of RAGE and HMGB1 variants with the risk of IS. A total of 1,034 patients and 1,015 age- and sex-matched healthy controls were genotyped to detect five genetic variants of the RAGE gene and four genetic variants of the HMGB1 gene using the Multiplex SNaPshot assay...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29241770/total-cholesterol-and-stroke-mortality-in-middle-aged-and-elderly-adults-a-prospective-cohort-study
#18
Sang-Wook Yi, Dae-Hee Shin, Hyeyun Kim, Jee-Jeon Yi, Heechoul Ohrr
BACKGROUND AND AIMS: The association between cholesterol and stroke has been inconsistent. This study aimed to examine the association between total cholesterol (TC) and mortality from total stroke and stroke subtypes. METHODS: 503,340 Korean adults aged 40-80 years without a history of heart disease or stroke participated in routine health examinations in 2002 and 2003, and were followed up until 2013. Adjusted hazard ratios (HRs) for stroke (I60-I69) mortality were calculated...
December 6, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29239099/double-layered-stents-for-carotid-angioplasty-a-meta-analysis-of-available-clinical-data
#19
Anna Sannino, Giuseppe Giugliano, Evelina Toscano, Gabriele G Schiattarella, Anna Franzone, Tullio Tesorio, Bruno Trimarco, Giovanni Esposito, Eugenio Stabile
OBJECTIVES: The objective of this meta-analysis is to evaluate clinical efficacy of double layered mesh covered carotid stent systems in the clinical practice. BACKGROUND: The need for an increase plaque coverage to decrease the risk of debris dislodgement through the stent struts, following carotid artery stenting (CAS), has brought to the design of a new generation of double layered carotid stents. Several small sized clinical studies evaluating two different devices have been recently published, unfortunately these are not sufficiently powered to test for device related and clinical endpoints and no comparison, between the two available devices, has been reported yet...
December 14, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29232701/differential-impact-of-white-matter-hyperintensities-on-long-term-outcomes-in-ischemic-stroke-patients-with-large-artery-atherosclerosis
#20
Minyoul Baik, Kyoungsub Kim, Joonsang Yoo, Hyeon Chang Kim, Seong Ho Jeong, Ki Hoon Kim, Hyung Jong Park, Young Dae Kim, Ji Hoe Heo, Hyo Suk Nam
BACKGROUND: The presence of white matter hyperintensity (WMH) is related to poor long-term outcomes in stroke patients. However, the long-term outcome is unknown in patients with both large artery atherosclerosis (LAA) and WMH. METHODS: We investigated the impact of WMH on long-term outcome in patients with LAA. Consecutive patients in a prospective stroke registry were included. Patients were followed for a median of 7.7 years (interquartile range, 5.6-9.7). The degree of WMH was assessed by Fazekas grade on fluid-attenuated inversion recovery images...
2017: PloS One
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