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Trauma plastics

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https://www.readbyqxmd.com/read/29349049/the-reliability-of-the-transconjunctival-approach-for-orbital-exposure-measurement-of-positional-changes-in-the-lower-eyelid
#1
Sung Ho Yoon, Jin Hoon Lee
Background: Lower eyelid incisions are widely used for the orbital approach in periorbital trauma and aesthetic surgery. In general, the subciliary approach is known to cause disposition of the lower eyelid by scarring the anterior lamella in some cases. On the other hand, many surgeons believe that a transconjunctival approach usually does not result in such complications and is a reliable method. We measured positional changes in the lower eyelid in blowout fracture repair since entropion is one of the most serious complications of the transconjunctival orbital approach...
December 2017: Archives of Craniofacial Surgery
https://www.readbyqxmd.com/read/29342029/association-of-involutional-lower-eyelid-entropion-with-reduced-upper-eyelid-position-relative-to-the-corneal-light-reflex-quantification-of-facial-asymmetry
#2
Paul O Phelps, Edward J Wladis, Dale R Meyer
PURPOSE: To investigate the association between upper eyelid position relative to the corneal light reflex (MRD1) and to delineate an association between eyelid height and involutional lower eyelid entropion. METHODS: Retrospective study of patients presenting for entropion repair to an academic ophthalmic plastic surgery service. A total of 111 patients were included in the study; 95 had unilateral involutional lower eyelid entropion, and 16 had bilateral lower eyelid entropion...
January 16, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29310513/sphingosine-1-phosphate-receptor-subtype-1-s1pr1-as-a-therapeutic-target-for-brain-trauma
#3
Salvatore Cuzzocrea, Timothy Doyle, Michela Campolo, Irene Paterniti, Emanuela Esposito, Susan Farr, Daniela Salvemini
Traumatic brain injury (TBI) provokes secondary pathological mechanisms, including ischemic and inflammatory processes. The new research in sphingosine 1-phosphate (S1P) receptor modulators has opened the door for an effective mechanism of reducing central nervous system (CNS) inflammatory lesion activity. Thus, the aim of this study was to characterize the immunomodulatory effect of the functional S1PR1 antagonist siponimod in Phase III clinical trials for autoimmune disorders and of the competitive S1PR1 antagonist TASP0277308 in preclinical development in an in vivo model of TBI in mice...
January 8, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29304820/degloving-injuries-with-versus-without-underlying-fracture-in-a-sub-saharan-african-tertiary-hospital-a-prospective-observational-study
#4
Hervé Monka Lekuya, Rose Alenyo, Isaac Kajja, Alexander Bangirana, Ronald Mbiine, Ater Ngoth Deng, Moses Galukande
BACKGROUND: Degloving injuries are surgical conditions in which an extensive portion of skin and subcutaneous tissue is detached from the underlying fasciae, muscles, or bone surface. Frequently, there is an association of fracture underlying the degloved area. We aimed to compare the short-term outcomes of degloving injuries with and without underlying fracture. METHODS: A prospective cohort study was conducted. We recruited patients with degloving injuries, and followed them up for 30 days to assess the outcomes...
January 5, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29244969/treatment-of-open-upper-limb-injuries-with-infection-prevention-and-negative-pressure-wound-therapy-a-systematic-review
#5
E Ali, M Raghuvanshi
OBJECTIVE: Open upper limb injuries requiring soft reconstruction can pose a dilemma for trauma surgeons when considering the treatment options. The British Orthopaedic Association and British Association of Plastic, Reconstructive and Aesthetic Surgeons Standard for Trauma (BOAST) have addressed the management of severe open lower limb fractures with the creation of the BOAST 4 guidelines. However, no such gold standard exists for the treatment of open injuries of the upper limb. Furthermore, treatment of these injuries is often more difficult and requires complicated strategies...
December 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29242989/prosthetic-supply-of-facial-defects-long-term-experience-and-retrospective-analysis-on-99-patients
#6
Giorgos Papaspyrou, Cansel Yildiz, Victoria Bozzato, Christopher Bohr, Mathias Schneider, Dietmar Hecker, Bernhard Schick, Basel Al Kadah
INTRODUCTION: Defects in the head region may be caused by tumour treatments, injuries, as well as congenital malformations. The restoration of these defects that can be performed through reconstructive plastic surgery and/or prosthetic surgery occupies a high priority in the physical and psychological rehabilitation of the patient. The present study reports on long-term experience in supply of facial prosthesis. MATERIALS AND METHODS: The medical records of 99 patients, who had been supplied with custom-made facial prostheses between 2001 and 2011, were evaluated retrospectively...
December 14, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29239728/wound-healing-of-cutaneous-substance-losses-based-on-infectious-inflammatory-and-traumatic-skin-disorders-the-experience-of-a-center
#7
K Khoshim, B Hersant, C Hotz, M SidAhmed-Mezi, J P Meningaud
INTRODUCTION: There is no reference available concerning the standard healing time based on dermatological diseases responsible for cutaneous substance losses. The aim of our study was to assess the healing time after surgical debridement of necrotizing fasciitis (NF), hidradenitis suppurativa (HS) and skin necrosis due to trauma (SNT) based on multiples existing co-morbidities among these patients to provide surgeons with accurate scientific data in order to inform and educate patients and nurses who are practicing care under the supervision of the surgeon...
November 24, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29232728/-conjunction-of-orthopaedic-and-trauma-surgery-the-leipzig-model-three-years-experiences-of-o%C3%A2-%C3%A2-u%C3%A2-%C3%A2-p-at-the-university-hospital-leipzig
#8
Christoph Eckhard Heyde, Pierre Hepp, Andreas Roth, Stefan Langer, Christoph Josten
The establishment and implementation of the combined specialisation of orthopaedic and trauma surgery in daily routine was and still is a huge challenge for all stakeholders. In recent years, major efforts have been made by the professional associations, the specialty societies and all parties involved in the implementation of this project. Basically, there is no general recipe for the implementation of such a concept. For each centre or clinic, the local structural, professional and historical circumstances must be meticulously taken into account when considering implementation of this concept...
December 12, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29218283/early-reconstructions-of-complex-lower-extremity-battlefield-soft-tissue-wounds
#9
Ali Ebrahimi, Nasrin Nejadsarvari, Azin Ebrahimi, Hamid Reza Rasouli
BACKGROUND: Severe lower extremity trauma as a devastating combat related injury is on the rise and this presents reconstructive surgeons with significant challenges to reach optimal cosmetic and functional outcomes. This study assessed early reconstructions of complex lower extremity battlefield soft tissue wounds. METHODS: This was a prospective case series study of battled field injured patients which was done in the Department of Plastic Surgery, Baqiyatallah University of Medical Sciences hospitals, Tehran, Iran between 2013-2015...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29203228/mild-fluid-percussion-injury-induces-diffuse-axonal-damage-and-reactive-synaptic-plasticity-in-the-mouse-olfactory-bulb
#10
Melissa A Powell, Raiford T Black, Terry L Smith, Thomas M Reeves, Linda L Phillips
Despite the regenerative capacity of the olfactory bulb (OB), head trauma causes olfactory disturbances in up to 30% of patients. While models of olfactory nerve transection, olfactory receptor neuron (ORN) ablation, or direct OB impact have been used to examine OB recovery, these models are severe and not ideal for study of OB synaptic repair. We posited that a mild fluid percussion brain injury (mFPI), delivered over mid-dorsal cortex, would produce diffuse OB deafferentation without confounding pathology...
December 1, 2017: Neuroscience
https://www.readbyqxmd.com/read/29193309/converging-early-responses-to-brain-injury-pave-the-road-to-epileptogenesis
#11
REVIEW
Eric J Neuberger, Akshay Gupta, Deepak Subramanian, Akshata A Korgaonkar, Vijayalakshmi Santhakumar
Epilepsy, characterized by recurrent seizures and abnormal electrical activity in the brain, is one of the most prevalent brain disorders. Over two million people in the United States have been diagnosed with epilepsy and 3% of the general population will be diagnosed with it at some point in their lives. While most developmental epilepsies occur due to genetic predisposition, a class of "acquired" epilepsies results from a variety of brain insults. A leading etiological factor for epilepsy that is currently on the rise is traumatic brain injury (TBI), which accounts for up to 20% of all symptomatic epilepsies...
November 29, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29187362/ikk2-nf-%C3%AE%C2%BAb-signaling-protects-neurons-after-traumatic-brain-injury
#12
Melanie Mettang, Stephanie Nadine Reichel, Michael Lattke, Annette Palmer, Alireza Abaei, Volker Rasche, Markus Huber-Lang, Bernd Baumann, Thomas Wirth
Traumatic brain injury (TBI) is the leading cause of death in young adults. After the initial injury, a poorly understood secondary phase, including a strong inflammatory response determines the final outcome of TBI. The inhibitor of NF-κB kinase (IKK)/NF-κB signaling system is the key regulator of inflammation and also critically involved in regulation of neuronal survival and synaptic plasticity. We addressed the neuron-specific function of IKK2/NF-κB signaling pathway in TBI using an experimental model of closed-head injury (CHI) in combination with mouse models allowing conditional regulation of IKK/NF-κB signaling in excitatory forebrain neurons...
November 29, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29184724/an-algorithmic-approach-to-operative-management-of-complex-pediatric-dog-bites-3-year-review-of-a-level-i-regional-referral-pediatric-trauma-hospital
#13
Kaveh Alizadeh, Ali Shayesteh, Min Li Xu
Background: Incidence of dog bites continues to rise among the pediatric population and serves as a public health threat for the well-being of children. Plastic surgeons are at the forefront of initial management and eventual outcome of these devastating injuries. This study set out to determine the nature of dog bite injuries treated over a 3-year period at a large level 1 pediatric trauma center. Methods: A retrospective review of emergency room records of all pediatric patients (age, 0-18 years old) who sustained dog bites between January 2012 and December 2014 were gathered...
October 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29181549/treating-open-lower-limb-fractures-successfully-thoughts-and-current-practice-on-therapy-and-centralization-in-the-netherlands
#14
K Oflazoglu, J M Hoogendoorn, P van der Zwaal, E T Walbeehm, W A van Enst, H R Holtslag, D Hofstee, P Plantinga, M Elzinga, H Rakhorst
INTRODUCTION: The British Orthopedic Association (BOA) and British Association of Plastic, Reconstructive and Aesthetic Surgeons (BAPRAS) updated the evidence-based guidelines for the treatment and care of open lower limb fractures (BOAST 4). Following this, a Dutch version has been developed. The main points are multidisciplinary care, planning, and treatment of these injuries. Early osteosynthesis (within 7-14 days) combined with soft-tissue coverage results in more efficient care and less complications...
November 27, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29175959/disrupted-neuro-glial-metabolic-coupling-after-peripheral-surgery
#15
Teresa Femenía, Alfredo Giménez-Cassina, Simone Codeluppi, Teresa Fernández-Zafra, Yurika Katsu-Jiménez, Niccolò Terrando, Lars I Eriksson, Marta Gómez-Galán
Immune-related events in the periphery can remotely affect brain function, contributing to neurodegenerative processes and cognitive decline. In mice, peripheral surgery induces a systemic inflammatory response associated with changes in hippocampal synaptic plasticity and transient cognitive decline, however the underlying mechanisms remain unknown. Here we investigated the effect of peripheral surgery on neuronal-glial function within hippocampal neuronal circuits of relevance to cognitive processing in male mice at 6, 24, and 72h post-surgery...
November 24, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29129793/the-interval-between-vns-tone-pairings-determines-the-extent-of-cortical-map-plasticity
#16
Michael S Borland, Crystal T Engineer, William A Vrana, Nicole A Moreno, Navzer D Engineer, Sven Vanneste, Pryanka Sharma, Meghan C Pantalia, Mark C Lane, Robert L Rennaker, Michael P Kilgard
Repeatedly pairing vagus nerve stimulation (VNS) with a tone or movement drives highly specific and long-lasting plasticity in auditory or motor cortex, respectively. Based on this robust enhancement of plasticity, VNS paired with rehabilitative training has emerged as a potential therapy to improve recovery, even when delivered long after the neurological insult. Development of VNS delivery paradigms that reduce therapy duration and maximize efficacy would facilitate clinical translation. The goal of the current study was to determine whether primary auditory cortex (A1) plasticity can be generated more quickly by shortening the interval between VNS-tone pairing events or by delivering fewer VNS-tone pairing events...
November 10, 2017: Neuroscience
https://www.readbyqxmd.com/read/29126650/plasticity-in-the-auditory-system
#17
REVIEW
Dexter R F Irvine
Over the last 30 years a wide range of manipulations of auditory input and experience have been shown to result in plasticity in auditory cortical and subcortical structures. The time course of plasticity ranges from very rapid stimulus-specific adaptation to longer-term changes associated with, for example, partial hearing loss or perceptual learning. Evidence for plasticity as a consequence of these and a range of other manipulations of auditory input and/or its significance is reviewed, with an emphasis on plasticity in adults and in the auditory cortex...
October 31, 2017: Hearing Research
https://www.readbyqxmd.com/read/29118550/-horrendoplasty-a-case-of-total-perineal-destruction-by-agricultural-implement
#18
Pedro Simoes de Oliveira, Tiago Ribeiro de Oliveira, David Martinho, Francisco Martins
Although posterior urethral injury occurs almost always in association with pelvic fracture, it may result from severe trauma to the perineum with its associated potential lethality and severe morbidity. Early primary endoscopic realignment over a urethral catheter can be attempted, although an immediate suprapubic tube placement remains the standard of care. Definitive treatment consists of elective open posterior anastomotic urethroplasty through a perineal approach. The authors present a 53-year-old man who sustained total, massive perineal destruction resulting from work accident with an agricultural implement...
October 2017: Urology Annals
https://www.readbyqxmd.com/read/29108856/etiology-of-pediatric-acquired-blepharoptosis
#19
Sulakshan Rasiah, Thomas G Hardy, James E Elder, Cheng Yi Ng, Alan McNab
PURPOSE: To describe the etiology of acquired pediatric blepharoptosis in a large clinical series and to elucidate the causes of the disease. METHODS: The medical records of all patients presenting with acquired blepharoptosis at two specialist ocular plastics practices and a pediatric ophthalmology practice during a period of up to 25 years were reviewed retrospectively and classified according to their diagnosis. Patients were grouped into children (<18 years), younger adults (18-40 years), and older adults (>40 years)...
November 3, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29104801/childhood-adversities-are-not-a-predictors-of-sstr4met-in-alcoholics
#20
Dominika Berent, Michał Pogórski, Dominika Kulczycka-Wojdala, Ewa Kusideł, Marian Macander, Zofia Pawłowska
Background: Genome methylation may modulate synaptic plasticity, being a potential background for mental disorder. Adverse childhood experiences (ACEs), known to be frequently reported by patients with alcohol dependence (AD), have been proposed as one of environmental inequities influencing DNA methylation. The study is aiming 1.To assess a promoter region methylation in gene for somatostatin receptor subtype-4 (SSTR4), a receptor for somatostatin, a neurotransmitter engaged in neuroplasticity and memory formation, in patients with AD; 2...
2017: Translational Neuroscience
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