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https://www.readbyqxmd.com/read/28532397/a-systematic-review-of-factors-that-shape-implementation-of-mass-drug-administration-for-lymphatic-filariasis-in-sub-saharan-africa
#1
Adam Silumbwe, Joseph Mumba Zulu, Hikabasa Halwindi, Choolwe Jacobs, Jessy Zgambo, Rosalia Dambe, Mumbi Chola, Gershom Chongwe, Charles Michelo
BACKGROUND: Understanding factors surrounding the implementation process of mass drug administration for lymphatic filariasis (MDA for LF) elimination programmes is critical for successful implementation of similar interventions. The sub-Saharan Africa (SSA) region records the second highest prevalence of the disease and subsequently several countries have initiated and implemented MDA for LF. Systematic reviews have largely focused on factors that affect coverage and compliance, with less attention on the implementation of MDA for LF activities...
May 22, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28459050/assessing-volumetric-absorptive-microsampling-coupled-with-stable-isotope-dilution-assay-and-liquid-chromatography-tandem-mass-spectrometry-as-potential-diagnostic-tool-for-whole-blood-5-methyltetrahydrofolic-acid
#2
Markus Kopp, Michael Rychlik
Volumetric absorptive microsamplers (VAMS) have been developed recently as a promising tool for clinical blood sampling. Compared to dried blood spot samples analyzed by accurate stable isotope dilution assays (SIDAs), the new technique could provide further substantial miniaturizing of folate assays by eliminating hematocrit effects and uneven analyte distribution within the sample. Herein, we present a miniaturized SIDA coupled with LC-MS/MS measurement of 5-methyltetrahydrofolic acid as main folate vitamer in whole blood (WB) using [(13)C5]-5-methyltetrahydrofolic acid as internal standard...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/28419223/removal-of-batch-effects-using-distribution-matching-residual-networks
#3
Uri Shaham, Kelly P Stanton, Jun Zhao, Huamin Li, Khadir Raddassi, Ruth Montgomery, Yuval Kluger
Motivation: Sources of variability in experimentally derived data include measurement error in addition to the physical phenomena of interest. This measurement error is a combination of systematic components, originating from the measuring instrument, and random measurement errors. Several novel biological technologies, such as mass cytometry and single-cell RNA-seq, are plagued with systematic errors that may severely affect statistical analysis if the data is not properly calibrated...
April 13, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28412575/the-role-of-illicit-licit-and-designer-drugs-in-the-traffic-in-hungary
#4
László Institóris, Előd Hidvégi, Adrienn Dobos, Éva Sija, Éva M Kereszty, László Balázs Tajti, Gábor Pál Somogyi, Tibor Varga
The aim of this study was to investigate the prevalence and pattern of psychoactive substances among suspected DUID (Driving Under the Influence of Drugs) drivers in Hungary in 2014 and 2015. Blood and/or urine samples of 1252 suspected drivers (600 in 2014 and 652 in 2015) were analyzed for classical illicit and licit drugs, stimulant designer drugs (SDDs), and for synthetic cannabinoids, with 78.3% and 79.6% positive cases for at least one substance in 2014, and 2015, respectively. Impairment was proven in 39...
April 3, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28367546/delineation-of-disease-phenotypes-associated-with-esophageal-adenocarcinoma-by-maldi-ims-ms-analysis-of-serum-n-linked-glycans
#5
M M Gaye, T Ding, H Shion, A Hussein, Y Hu, S Zhou, Z T Hammoud, B K Lavine, Y Mechref, J C Gebler, D E Clemmer
N-Linked glycans, extracted from patient sera and healthy control individuals, are analyzed by Matrix-assisted laser desorption ionization (MALDI) in combination with ion mobility spectrometry (IMS), mass spectrometry (MS) and pattern recognition methods. MALDI-IMS-MS data were collected in duplicate for 58 serum samples obtained from individuals diagnosed with Barrett's esophagus (BE, 14 patients), high-grade dysplasia (HGD, 7 patients), esophageal adenocarcinoma (EAC, 20 patients) and disease-free control (NC, 17 individuals)...
May 2, 2017: Analyst
https://www.readbyqxmd.com/read/28363433/improved-skeletal-muscle-mass-and-strength-after-heavy-strength-training-in-very-old-individuals
#6
Rasmus Leidesdorff Bechshøft, Nikolaj Mølkjær Malmgaard-Clausen, Bjørn Gliese, Nina Beyer, Abigail L Mackey, Jesper Løvind Andersen, Michael Kjær, Lars Holm
Age-related loss of muscle mass and function represents personal and socioeconomic challenges. The purpose of this study was to determine the adaptation of skeletal musculature in very old individuals (83+ years) performing 12weeks of heavy resistance training (3×/week) (HRT) compared to a non-training control group (CON). Both groups received similar protein supplementations. We studied 26 participants (86.9±3.2 (SD) (83-94, range) years old) per-protocol. Quadriceps cross-sectional area (CSA) differed between groups at post-test (P<0...
June 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28338663/prevalence-and-associated-factors-of-blepharoptosis-in-korean-adult-population-the-korea-national-health-and-nutrition-examination-survey-2008-2011
#7
M H Kim, J Cho, D Zhao, K I Woo, Y-D Kim, S Kim, S W Yang
PurposeThis study aimed to evaluate the prevalence and associated factors of involutional blepharoptosis in a nationwide representative sample in Korea.MethodsCross-sectional study 20 941 Korean men and women 40 years of age and older who participated in last 2 years (2008 and 2009) of the 4th wave of the Korean National Health and Nutrition Examination Survey (KNHANES) IV and the first 2 years (2010 and 2011) of KNHANES V. Ocular examinations were performed by ophthalmologists trained in procedure and grading methods, and blepharoptosis was defined as a marginal reflex distance <2 mm on either eye...
March 24, 2017: Eye
https://www.readbyqxmd.com/read/28295860/relationships-between-mri-breast-imaging-reporting-and-data-system-bi-rads-lexicon-descriptors-and-breast-cancer-molecular-subtypes-internal-enhancement-is-associated-with-luminal-b-subtype
#8
Lars J Grimm, Jing Zhang, Jay A Baker, Mary S Soo, Karen S Johnson, Maciej A Mazurowski
The aim of this study was to determine the associations between breast MRI findings using the Breast Imaging-Reporting and Data System (BI-RADS) lexicon descriptors and breast cancer molecular subtypes. In this retrospective, IRB-approved, single institution study MRIs from 278 women with breast cancer were reviewed by one of six fellowship-trained breast imagers. Readers reported BI-RADS descriptors for breast masses (shape, margin, internal enhancement) and non-mass enhancement (distribution, internal enhancement)...
March 13, 2017: Breast Journal
https://www.readbyqxmd.com/read/28287024/combined-training-fndc5-irisin-levels-and-metabolic-markers-in-obese-men-a-randomised-controlled-trial
#9
Ivan Luiz Padilha Bonfante, Mara Patrícia Traina Chacon-Mikahil, Diego Trevisan Brunelli, Arthur Fernandes Gáspari, Renata Garbellini Duft, Wendell Arhur Lopes, Valéria Bonganha, Cleiton Augusto Libardi, Cláudia Regina Cavaglieri
The effects of training on FNDC5/irisin and its association with fitness and metabolic marker improvements induced by training have been poorly investigated in humans. Thus, the present study assessed the effects of combined training (CT) on FNDC5/irisin levels, metabolic markers and fitness adaptations in obese men. Middle-age obese men (age 49.13 ± 5.75, body mass index (BMI) 30.86 ± 1.63) were randomly distributed in the CT group (n = 12) and control group (CG n = 10). The CT consisted of strength followed by aerobic training, 3 times/week, for 24 weeks...
March 13, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28279455/modelling-the-elimination-of-river-blindness-using-long-term-epidemiological-and-programmatic-data-from-mali-and-senegal
#10
Martin Walker, Wilma A Stolk, Matthew A Dixon, Christian Bottomley, Lamine Diawara, Mamadou O Traoré, Sake J de Vlas, María-Gloria Basáñez
The onchocerciasis transmission models EPIONCHO and ONCHOSIM have been independently developed and used to explore the feasibility of eliminating onchocerciasis from Africa with mass (annual or biannual) distribution of ivermectin within the timeframes proposed by the World Health Organization (WHO) and endorsed by the 2012 London Declaration on Neglected Tropical Diseases (i.e. by 2020/2025). Based on the findings of our previous model comparison, we implemented technical refinements and tested the projections of EPIONCHO and ONCHOSIM against long-term epidemiological data from two West African transmission foci in Mali and Senegal where the observed prevalence of infection was brought to zero circa 2007-2009 after 15-17 years of mass ivermectin treatment...
March 2017: Epidemics
https://www.readbyqxmd.com/read/28278066/characterization-of-exposure-to-byproducts-from-firing-lead-free-frangible-ammunition-in-an-enclosed-ventilated-firing-range
#11
Christin M Grabinski, Mark M Methner, Jerimiah M Jackson, Alexander L Moore, Laura E Flory, Trevor Tilly, Saber M Hussain, Darrin K Ott
U.S. Air Force small arms firing ranges began using copper-based, lead-free frangible ammunition in the early 2000s due to environmental and health concerns related to the use of lead-based ammunition. Exposure assessments at these firing ranges have routinely detected chemicals and metals in amounts much lower than their mass-based occupational exposure limits, yet, instructors report work-related health concerns including respiratory distress, nausea, and headache. The objective of this study at one firing range was to characterize the aerosol emissions produced by weapons during firing events and evaluate the ventilation system's effectiveness in controlling instructor exposure to these emissions...
February 26, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28260558/medical-response-to-a-vinyl-chloride-release-from-a-train-derailment-new-jersey-2012
#12
Alice M Shumate, Jamille Taylor, Elizabeth McFarland, Christina Tan, Mary Anne Duncan
OBJECTIVE: The objective of this investigation was to examine the health impact of and medical response to a mass casualty chemical incident caused by a vinyl chloride release. METHODS: Key staff at area hospitals were interviewed about communication during the response, the number of patients treated and care required, and lessons learned. Clinical information related to the incident and medical history were abstracted from hospital charts. RESULTS: Hospital interviews identified a desire for more thorough and timely incident-specific information and an under-utilization of regionally available resources...
March 6, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28229646/special-nutrition-intervention-is-required-for-muscle-protective-efficacy-of-physical-exercise-in-elderly-people-at-highest-risk-of-sarcopenia
#13
A Molnár, I Jónásné Sztruhár, Á A Csontos, Cs Ferencz, Sz Várbíró, B Székács
Progressive loss of muscle mass and strength is a physiological consequence of aging, and without interventions, it usually deteriorates into sarcopenia. In this study, the hypothesis that combined special nutritional-physiotherapeutical intervention to prevent or reverse this biological deterioration in elderly people was tested. The effects of the regular resistance muscle training (PT, n = 17) alone and the combined exercise + special nutrition therapy containing whey protein and vitamin D (PT + NT, n = 17) were monitored for 3 months in 34 elderly patients (12 men and 22 women; mean age: 66...
September 2016: Physiology International
https://www.readbyqxmd.com/read/28197029/stepwise-case-selection-using-guy-s-stone-score-reduces-complications-during-percutaneous-nephrolithotomy-training
#14
Jiten Jaipuria, Manav Suryavanshi, Amitsinh P Desai, Sanjay Goyal, Kaushal Patel, Sandip S Parhad, Santosh K Subudhi, Chandrashekar V Rao, Satish P Kumar, Tridib K Sen
INTRODUCTION: Traditional percutaneous nephrolithotomy (PCNL) training involved subjective award of cases to the trainee. We restructured this according to the Guy's stone score (GSS) such that each trainee stepwise completed 25 cases of each grade before progressing. This study compares the outcomes of training with traditional versus stepwise approach. METHODS: Four hundred consecutive cases equally distributed for two trainees in each group were compared in terms of complications (Clavien-Dindo), stone free rate (SFR), operative and fluoroscopy time...
January 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28191907/anthropometric-parameters-and-the-incidence-of-atrial-fibrillation-in-older-people-the-pro-v-a-study
#15
Caterina Trevisan, Stefania Maggi, Chiara Curreri, Giovanni Nante, Marianna Noale, Marina De Rui, Egle Perissinotto, Leonardo Sartori, Sabina Zambon, Gaetano Crepaldi, Enzo Manzato, Giuseppe Sergi
BACKGROUND: Atrial fibrillation (AF) has been associated with body size and central obesity, but the impact of different anthropometric measures in this relationship has been inadequately investigated. HYPOTHESIS: In this study, we examined the association between baseline anthropometric parameters with the incidence of AF in older people, hypothesizing that body size could impact the onset of AF more than fat distribution. METHODS: Our study included 1764 participants with a mean age of 74...
February 13, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28153354/sport-and-sample-specific-features-of-trace-elements-in-adolescent-female-field-hockey-players-and-fencers
#16
Alexey A Nabatov, Natalya A Troegubova, Ruslan R Gilmutdinov, Andrey P Sereda, Alexander S Samoilov, Natalya V Rylova
Active physical exercises and growth are associated with mineral imbalances in young athletes. The purpose of this study was to examine the impact of sport-related factors on tissue mineral status in adolescent female athletes. Saliva and hair samples were used for the analysis of immediate and more permanent tissue mineral status, respectively. Samples taken from a control non-athletic female group and two groups of female athletes (field hockey and fencing) were analyzed for seven essential minerals: calcium, chromium, iron, potassium, magnesium, selenium and zinc...
November 5, 2016: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28148306/agonist-muscle-adaptation-accompanied-by-antagonist-muscle-atrophy-in-the-hindlimb-of-mice-following-stretch-shortening-contraction-training
#17
Erik P Rader, Marshall A Naimo, James Ensey, Brent A Baker
BACKGROUND: The vast majority of dynamometer-based animal models for investigation of the response to chronic muscle contraction exposure has been limited to analysis of isometric, lengthening, or shortening contractions in isolation. An exception to this has been the utilization of a rat model to study stretch-shortening contractions (SSCs), a sequence of consecutive isometric, lengthening, and shortening contractions common during daily activity and resistance-type exercise. However, the availability of diverse genetic strains of rats is limited...
February 2, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28146437/an-acceleration-profile-of-elite-gaelic-football-match-play
#18
Martin Ryan, Shane Malone, Kieran Collins
The use of global positioning system (GPS) technology in Gaelic football is the primary source of quantifying game demands. The aim of the current study was to quantify the acceleration profile of elite Gaelic football. Thirty-six elite male Gaelic football players (Mean ± SD, age: 24 ± 6 years; height: 180 ± 7 cm; mass: 81 ± 7 kg) across five playing positions took part in a multiple study (n = 154 observations). Player movement was recorded during nineteen (n = 19) competitive games over 2 seasons using 4-Hz GPS (VXSport, New Zealand)...
January 28, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28140624/normative-data-for-the-neurocom-sensory-organization-test-in-us-military-special-operations-forces
#19
Erin R Pletcher, Valerie J Williams, John P Abt, Paul M Morgan, Jeffrey J Parr, Meleesa F Wohleber, Mita Lovalekar, Timothy C Sell
CONTEXT: Postural stability is the ability to control the center of mass in relation to a person's base of support and can be affected by both musculoskeletal injury and traumatic brain injury. The NeuroCom Sensory Organization Test (SOT) can be used to objectively quantify impairments to postural stability. The ability of postural stability to predict injury and be used as an acute injury-evaluation tool makes it essential to the screening and rehabilitation process. To our knowledge, no published normative data for the SOT from a healthy, highly active population are available for use as a reference for clinical decision making...
February 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/27918669/within-season-distribution-of-external-training-and-racing-workload-in-professional-male-road-cyclists
#20
Alan J Metcalfe, Paolo Menaspà, Vincent Villerius, Marc Quod, Jeremiah J Peiffer, Andrew D Govus, Chris R Abbiss
PURPOSE: To describe the within-season external workloads of professional male road cyclists for optimal training prescription. METHODS: Training and racing of 4 international competitive professional male cyclists (age 24 ± 2 y, body mass 77.6 ± 1.5 kg) were monitored for 12 mo before the world team-time-trial championships. Three within-season phases leading up to the team-time-trial world championships on September 20, 2015, were defined as phase 1 (Oct-Jan), phase 2 (Feb-May), and phase 3 (June-Sept)...
April 2017: International Journal of Sports Physiology and Performance
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