Mark R Viant, E Amstalden, T Athersuch, M Bouhifd, S Camuzeaux, D M Crizer, P Driemert, T Ebbels, D Ekman, B Flick, V Giri, M Gómez-Romero, V Haake, M Herold, A Kende, F Lai, P E G Leonards, P P Lim, G R Lloyd, J Mosley, C Namini, J R Rice, S Romano, C Sands, M J Smith, T Sobanski, A D Southam, L Swindale, B van Ravenzwaay, T Walk, R J M Weber, F M Zickgraf, H Kamp
While grouping/read-across is widely used to fill data gaps, chemical registration dossiers are often rejected due to weak category justifications based on structural similarity only. Metabolomics provides a route to robust chemical categories via evidence of shared molecular effects across source and target substances. To gain international acceptance, this approach must demonstrate high reliability, and best-practice guidance is required. The MetAbolomics ring Trial for CHemical groupING (MATCHING), comprising six industrial, government and academic ring-trial partners, evaluated inter-laboratory reproducibility and worked towards best-practice...
February 18, 2024: Archives of Toxicology