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https://www.readbyqxmd.com/read/28635565/prostate-cancer-stem-cells-from-theory-to-practice
#1
Jan Adamowicz, Katayoon Pakravan, Babak Bakhshinejad, Tomasz Drewa, Sadegh Babashah
None of the generally accepted theories on prostate cancer development can fully explain many distinguishing features of the disease, such as intratumoral heterogeneity, metastatic growth, drug resistance and tumor relapse. Prostate stem cells are a heterogeneous and small subpopulation of self-renewing cells which can actively proliferate in response to changes in the androgen level and give rise to all the cell lineages that build the prostate epithelium. According to the cancer stem cell hypothesis, prostate cancer could be a stem cell disease...
February 7, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28632050/effects-of-turf-and-cleat-footwear-on-plantar-load-distributions-in-adolescent-american-football-players-during-resisted-pushing
#2
Jeffrey B Taylor, Anh-Dung Nguyen, Janet R Griffin, Kevin R Ford
Metatarsal and midfoot injuries are common in American football. Footwear design may influence injury rates by altering plantar foot loading patterns in these regions. The purpose of this study was to determine the effect of cleat design on in-shoe plantar foot loading during a football-specific, resisted pushing task. Twenty competitive football players (age 14.7 ± 1.8 years, height 1.72 ± 0.10 m, and mass 71.8 ± 26.9 kg) completed three trials of pushing a weighted sled at maximal effort in a standard shoe (CLEAT) and artificial turf-specific shoe (TURF), with flexible in-shoe force measuring insoles...
February 28, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/28621751/geographic-variations-in-cardiometabolic-risk-factors-in-luxembourg
#3
Ala'a Alkerwi, Illiasse El Bahi, Saverio Stranges, Jean Beissel, Charles Delagardelle, Stephanie Noppe, Ngianga-Bakwin Kandala
Cardiovascular disease (CVD) and associated behavioural and metabolic risk factors constitute a major public health concern at a global level. Many reports worldwide have documented different risk profiles for populations with demographic variations. The objective of this study was to examine geographic variations in the top leading cardio metabolic and behavioural risk factors in Luxembourg, in order to provide an overall picture of CVD burden across the country. The analysis conducted was based on data from the nationwide ORISCAV-LUX survey, including 1432 subjects, aged 18-69 years...
June 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28558814/approach-to-growth-hormone-therapy-in-children-with-chronic-kidney-disease-varies-across-north-america-the-midwest-pediatric-nephrology-consortium-report
#4
Oleh M Akchurin, Amy J Kogon, Juhi Kumar, Christine B Sethna, Hoda T Hammad, Paul J Christos, John D Mahan, Larry A Greenbaum, Robert Woroniecki
BACKGROUND: Growth impairment remains common in children with chronic kidney disease (CKD). Available literature indicates low level of recombinant human growth hormone (rhGH) utilization in short children with CKD. Despite efforts at consensus guidelines, lack of high-level evidence continues to complicate rhGH therapy decision-making and the level of practice variability in rhGH treatment by pediatric nephrologists is unknown. METHODS: Cross-sectional online survey electronically distributed to pediatric nephrologists through the Midwest Pediatric Nephrology Consortium and American Society of Pediatric Nephrology...
May 30, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28558284/characterization-of-pm2-5-exposure-concentration-in-transport-microenvironments-using-portable-monitors
#5
Zhiyuan Li, Wenwei Che, H Christopher Frey, Alexis K H Lau, Changqing Lin
Recently, portable monitors have been increasingly used to quantify air pollutant concentrations at high spatiotemporal resolution. A sampling campaign was conducted to measure the fine particulate matter (PM2.5) and carbon monoxide (CO) exposure concentrations in transport microenvironments (TMEs) in Hong Kong in January and June 2015 using TSI DustTrak and Q-Trak portable monitors. The objectives were to: (1) calibrate DustTrak and Q-Trak; (2) evaluate variability between seasons and microenvironments; (3) estimate indoor/outdoor relationships; and (4) determine minimum sample size...
May 27, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28546705/sinonasal-mass-a-recent-study-of-its-clinicopathological-profile
#6
P Agarwal, R Panigrahi
A variety of non-neoplastic and neoplastic conditions involving the nasal cavity, paranasal sinuses (PNS), and nasopharynx are commonly encountered in clinical practice. The objectives of the study were to identify various pathological conditions that present with sinus or nasal mass, to understand their varied clinical behavior, to know the distribution of various lesions among the different age and sex groups, and to study the management of sinonasal masses and its outcome on follow-up. A prospective study was carried out from September 2013 to August 2015, in the Otorhinolaryngology Department of Hi-Tech Medical College & Hospital, Bhubaneswar, Odisha...
June 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28528194/analysis-of-peg-oligomers-in-black-gel-inks-discrimination-and-ink-dating
#7
Qiran Sun, Yiwen Luo, Ping Xiang, Xu Yang, Min Shen
Carbon-based black gel inks are common samples in forensic practice of questioned document examination in China, but there are few analytical methods for this type of ink. In this study, a liquid chromatography-.high resolution mass spectrometry (LC-HRMS) method was established for the analysis of PEG oligomers in carbon-based black gel ink entries. The coupled instruments achieve both the identification and quantification of PEG oligomers in ink entries with reproducible results. Twenty carbon-based black gel inks, whose Raman spectra appeared identical, were analyzed using the LC-HRMS method...
May 4, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28514898/assessment-of-cryosurgical-device-performance-using-a-3d-tissue-engineered-cancer-model
#8
John M Baust, Anthony Robilotto, Kristi K Snyder, Kimberly Santucci, Jennie Stewart, Robert Van Buskirk, John G Baust
As the clinical use of cryoablation for the treatment of cancer has increased, so too has the need for knowledge on the dynamic environment within the frozen mass created by a cryoprobe. While a number of factors exist, an understanding of the iceball size, critical isotherm distribution/penetration, and the resultant lethal zone created by a cryoprobe are critical for clinical application. To this end, cryoprobe performance is typically characterized based on the iceball size and temperature penetration in phantom gel models...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28513289/detection-of-meat-species-adulteration-using-high-resolution-mass-spectrometry-and-a-proteogenomics-strategy
#9
Alberto Ruiz Orduna, Erik Husby, Charles T Yang, Dipankar Ghosh, Francis Beaudry
Due to the internationalisation of food production and distribution, there has been a significant increase of food fraud in recent years. Food fraud can have serious health implications, and it occurs when food manufacturers implement unethical practices such as making false label claims as well as using additives and fillers within their products to increase profitability. This has been a serious concern. Meat adulteration was examined using a well-defined proteogenomic annotation, carefully selected surrogate tryptic peptides and high-resolution mass spectrometry...
June 20, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28511057/mapping-smokeless-powder-residue-on-pvc-pipe-bomb-fragments-using-total-vaporization-solid-phase-microextraction
#10
Dana Bors, John Goodpaster
Quantitating post-blast explosive residue is not a common practice in crime labs as it is typically not legally relevant. There is value in quantitation, however, if the distribution of residues on Improvised Explosive Devices (IEDs) can help guide future sample collection and/or method development. Total vaporization solid phase microextraction gas chromatography mass spectrometry (TV-SPME/GC/MS) was used to quantify residues of double-base smokeless powder (DBSP), which includes nitroglycerin (NG), diphenylamine (DPA), and ethyl centralite (EC) on post-blast PVC pipe bomb fragments...
April 14, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28485319/dynamic-change-of-red-cell-distribution-width-levels-in-prediction-of-hospital-mortality-in-chinese-elderly-patients-with-septic-shock
#11
Xue-Feng Ju, Fei Wang, Li Wang, Xiao Wu, Ting-Ting Jiang, Da-Li You, Bing-Hua Yang, Jian-Jun Xia, Shan-You Hu
BACKGROUND: The normal range of red cell distribution width (RDW) level is <15%. Several studies have indicated that a high RDW level was associated with mortality in critically ill patients, and the patients with a high RDW level need increased focus in clinical practice. In view of the difficulty in defining the specific value of high RDW level, the key is to focus on the patient with the level beyond the normal upper limit. This study aimed to determine whether dynamic change of RDW levels, rather than the level itself, is predictive of death in elderly patients with septic shock when RDW level is beyond 15%...
May 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28475651/pharmacokinetic-modeling-of-gentamicin-in-treatment-of-infective-endocarditis-model-development-and-validation-of-existing-models
#12
Anna Gomes, Lars van der Wijk, Johannes H Proost, Bhanu Sinha, Daan J Touw
Gentamicin shows large variations in half-life and volume of distribution (Vd) within and between individuals. Thus, monitoring and accurately predicting serum levels are required to optimize effectiveness and minimize toxicity. Currently, two population pharmacokinetic models are applied for predicting gentamicin doses in adults. For endocarditis patients the optimal model is unknown. We aimed at: 1) creating an optimal model for endocarditis patients; and 2) assessing whether the endocarditis and existing models can accurately predict serum levels...
2017: PloS One
https://www.readbyqxmd.com/read/28474288/could-lymphocyte-profiling-be-useful-to-diagnose-systemic-autoimmune-diseases
#13
REVIEW
Guillermo Carvajal Alegria, Pierre Gazeau, Sophie Hillion, Claire I Daïen, Divi Y K Cornec
Considering the implications of B, T, and natural killer (NK) cells in the pathophysiology of systemic autoimmune diseases, the assessment of their distribution in the blood could be helpful for physicians in the complex process of determining a precise diagnosis. In primary Sjögren's syndrome, transitional and active naive B cells are increased and memory B cells are decreased compared to healthy controls and other systemic diseases. However, their utility to improve the accuracy of classification criteria has not been proven...
May 4, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28443941/knowledge-attitudes-and-perceptions-regarding-lymphatic-filariasis-study-on-systematic-noncompliance-with-mass-drug-administration
#14
Silvia Cabral, Cristine Bonfim, Rosalira Oliveira, Paula Oliveira, Terezinha Guimarães, Eduardo Brandão, Ana Maria Aguiar-Santos, Zulma Medeiros
The aim of this study was to investigate the epidemiological characteristics, antigenic profile, perceptions, attitudes and practices of individuals who have been systematically non-compliant in mass drug administration (MDA) campaigns targeting lymphatic filariasis, in the municipality of Olinda, State of Pernambuco, Northeastern Brazil. A pretested questionnaire was used to obtain information on socioenvironmental demographics, perceptions of lymphatic filariasis and MDA, and reasons for systematic noncompliance with treatment...
April 20, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28435553/prevalence-and-associated-factors-of-musculoskeletal-disorders-among-young-dentists-in-indonesia
#15
P Phedy, L Gatam
Introduction: Musculoskeletal problems are often work related. Dentists have been reported to have a high prevalence of musculoskeletal problems. Dentists have to perform repetitive tasks, often in awkward and nonergonomic positions in their practice. Materials and Methods: This is a cross-sectional study. Five-hundred copies of Nordic Musculoskeletal Questionnaire were distributed to dentists who participated in a congress of a regional branch of the Indonesian Dentist Association. Data such as sex, length of practice, the presence of assistance, smoking, occupational stress, body mass index, hand dominance, and exercise were collected...
July 2016: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/28395343/the-generation-rate-of-respirable-dust-from-cutting-fiber-cement-siding-using-different-tools
#16
Chaolong Qi, Alan Echt, Michael G Gressel
This article describes the evaluation of the generation rate of respirable dust (GAPS, defined as the mass of respirable dust generated per unit linear length cut) from cutting fiber cement siding using different tools in a laboratory testing system. We used an aerodynamic particle sizer spectrometer (APS) to continuously monitor the real-time size distributions of the dust throughout cutting tests when using a variety of tools, and calculated the generation rate of respirable dust for each testing condition using the size distribution data...
March 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28391999/trends-in-management-of-the-small-renal-mass-in-renal-transplant-recipient-candidates-a-multi-institutional-survey-analysis
#17
Alp Tuna Beksac, David J Paulucci, John P Sfakianos, Balaji N Reddy, Greg E Gin, Susan M Lerner, Ketan K Badani
INTRODUCTION: Patients with end-stage renal disease are under increased risk for renal cell carcinoma development, and radical nephrectomy is the preferred treatment in this setting. Owing to the increased surgical morbidity and mortality, active surveillance (AS) may be a valid option for treatment of small renal masses (SRM). As there is a lack of high-level evidence for treatment recommendations, we performed a survey analysis to analyze the treatment patterns of transplant surgeons...
April 5, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28374728/-characteristic-of-the-normal-values-of-the-pain-threshold-values-in-the-dorsal-region-of-the-young-women-obtained-by-the-pressure-algometry-method-under-different-condition
#18
P V Kondrashkin, D Z Shibkova, E I Tolstykh
The application of modern techniques for different types of massage and manual therapy is associated with the exposure of the paravetrebral points. The knowledge of pain threshold values at these points is of great practical significance. AIM: The objective of the present study was to obtain the statistical characteristics of the individual pressure pain threshold (PPT) for the healthy women and patients presenting with minor disturbances of spinal motion segments (SMS) at the trigger points on the back...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/28365763/the-effect-of-nest-box-distribution-on-sustainable-propagation-of-osmia-lignaria-hymenoptera-megachilidae-in-commercial-tart-cherry-orchards
#19
N K Boyle, T L Pitts-Singer
The blue orchard bee, Osmia lignaria (Say), is a solitary bee that is an excellent pollinator of tree fruit orchards. Due to the annual rising costs of honey bee hive rentals, many orchardists are eager to develop management tools and practices to support O. lignaria as an alternative pollinator. Establishing O. lignaria pollination as a sustainable industry requires careful consideration of both bee and orchard management. Here, we test the effect of artificial nest box distribution on in-orchard propagation of O...
January 1, 2017: Journal of Insect Science
https://www.readbyqxmd.com/read/28361600/application-of-drifts-13-c-nmr-and-py-mbms-to-characterize-the-effects-of-soil-science-oxidation-assays-on-soil-organic-matter-composition-in-a-mollic-xerofluvent
#20
Andrew J Margenot, Francisco J Calderón, Kimberly A Magrini, Robert J Evans
Chemical oxidations are routinely employed in soil science to study soil organic matter (SOM), and their interpretation could be improved by characterizing oxidation effects on SOM composition with spectroscopy. We investigated the effects of routinely employed oxidants on SOM composition in a Mollic Xerofluvent representative of intensively managed agricultural soils in the California Central Valley. Soil samples were subjected to oxidation by potassium permanganate (KMnO4), sodium hypochlorite (NaOCl), and hydrogen peroxide (H2O2)...
January 1, 2017: Applied Spectroscopy
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