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https://www.readbyqxmd.com/read/28208116/factors-determining-left-main-coronary-artery-luminal-area
#1
Konstantinos Dean Boudoulas, Peter M Bittenbender, Haikady N Nagaraja, Omar Kahaly, Jennifer A Dickerson, Subha V Raman, Ernest L Mazzaferri, Charles A Bush
BACKGROUND: A certain minimal luminal cross-sectional area has been traditionally used in clinical practice as a cut-off value to determine severity of left main coronary artery (LMCA) stenosis. The severity of stenosis, however, depends on the baseline luminal area (ie, area prior to stenosis), which may vary among individuals. The present study was undertaken to define normal LMCA luminal area using current technology in vivo. METHODS: LMCA luminal area was determined using multislice computed tomography coronary angiography...
February 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28205246/pharmacokinetics-of-valnemulin-after-intravenous-intramuscular-and-oral-administration-in-layer-chickens
#2
F Sun, R Fan, J Wang, L Xiong, J Shen, S Zhang, X Cao
The pharmacokinetic characteristics of valnemulin in layer chickens were studied after single intravenous, intramuscular, and oral administration at a dose of 15 mg/kg body weight. Plasma samples at certain time points were collected and the drug concentrations in them by ultra high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS). The concentration-time data for each individual were plotted by noncompartmental analysis for the whole three routes. Following intravenous administration, the plasma concentration showed tiny fluctuation...
February 15, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28199877/characterising-stormwater-gross-pollutants-captured-in-catch-basin-inserts
#3
Md Zahanggir Alam, A H M Faisal Anwar, Dipok Chandra Sarker, Anna Heitz, Craig Rothleitner
The accumulation of wash-off solid waste, termed gross pollutants (GPs), in drainage systems has become a major constraint for best management practices (BMPs) of stormwater. GPs should be captured at source before the material clogs the drainage network, seals the infiltration capacity of side entry pits or affects the aquatic life in receiving waters. BMPs intended to reduce stormwater pollutants include oil and grit separators, grassed swales, vegetated filter strips, retention ponds, and catch basin inserts (CBIs) are used to remove GP at the source and have no extra land use requirement because they are typically mounted within a catch basin (e...
February 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28198615/antibacterial-activities-of-graphene-oxide-molybdenum-disulfide-nanocomposite-films
#4
Tae In Kim, Buki Kwon, Jonghee Yoon, Ick-Joon Park, Gyeong Sook Bang, YongKeun Park, Yeon-Soo Seo, Sung-Yool Choi
Two-dimensional (2D) nanomaterials, such as graphene-based materials and transition metal dichalcogenide (TMD) nanosheets, are promising materials for biomedical applications owing to their remarkable cytocompatibility and physicochemical properties. Based on their potent antibacterial properties, 2D materials have potential as antibacterial films, wherein the 2D nanosheets are immobilized on the surface and the bacteria may contact with the basal planes of 2D nanosheets dominantly rather than contact with the sharp edges of nanosheets...
February 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28164430/assessment-of-intradialysis-calcium-mass-balance-by-single-pool-variable-volume-calcium-kinetic-model
#5
Salvatore di Filippo, Fabio Carfagna, Vincenzo la Milia, Antonio Bellasi, Giustina Casagrande, Camilla Bianchi, Domenico Vito, Maria Laura Costantino, Giuseppe Rombolà, Claudio Minoretti, Carlo Schönholzer, Giuseppe Pontoriero, Francesco Locatelli
INTRODUCTION: A reliable method of intradialysis calcium mass balance quantification is far from been established. We herein investigated the use of a single-pool variable-volume Calcium kinetic model to assess calcium mass balance in chronic and stable dialysis patients. METHODS: Thirty-four patients on thrice-weekly HD were studied during 240 dialysis sessions. All patients were dialyzed with a nominal total calcium concentration of 1.50 mmol/L. The main assumption of the model is that the calcium distribution volume is equal to the extracellular volume during dialysis...
February 5, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28155137/successful-use-of-14-c-paracetamol-microdosing-to-elucidate-developmental-changes-in-drug-metabolism
#6
Miriam G Mooij, Esther van Duijn, Catherijne A J Knibbe, Karel Allegaert, Albert D Windhorst, Joost van Rosmalen, N Harry Hendrikse, Dick Tibboel, Wouter H J Vaes, Saskia N de Wildt
BACKGROUND: We previously showed the practical and ethical feasibility of using [(14)C]-microdosing for pharmacokinetic studies in children. We now aimed to show that this approach can be used to elucidate developmental changes in drug metabolism, more specifically, glucuronidation and sulfation, using [(14)C]paracetamol (AAP). METHODS: Infants admitted to the intensive care unit received a single oral [(14)C]AAP microdose while receiving intravenous therapeutic AAP every 6 h...
February 2, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28145118/use-of-winemaking-supplements-to-modify-the-composition-and-sensory-properties-of-shiraz-wine
#7
Sijing Li, Keren A Bindon, Susan Elaine Putnam Bastian, Vladimir Jiranek, Kerry L Wilkinson
Wine quality can be significantly impacted by tannin and polysaccharide composition, which can in turn be influenced by grape maturity and winemaking practices. This study explored the impact of three commercial wine additives, a maceration enzyme, an oenotannin and a mannoprotein, on the composition and sensory properties of red wine; in particular, in mimicking the mouthfeel associated with wines made from riper grapes. Shiraz grapes were harvested at 24 °Brix and 28 °Brix and the former vinified with commercial additives introduced either individually or in combination...
February 1, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28133763/the-effects-of-patient-positioning-when-interpreting-ct-dose-metrics-a-phantom-study
#8
Rebecca M Marsh, Michael S Silosky
PURPOSE: Review of dose metrics as part of the routine evaluation of CT protocols has become commonplace and is required by the Joint Commission and the American College of Radiology for accreditation. Most CT quality assurance programs include a review of CTDIvol and/or SSDE, both of which are affected by changes in mAs and kV. mAs, and sometimes kV, are largely determined by the Tube Current Modulation (TCM) functions of the scanner. TCM, in turn, relies on localizer scans to provide an accurate estimate of patient size...
January 30, 2017: Medical Physics
https://www.readbyqxmd.com/read/28095873/physical-integrity-and-residual-bio-efficacy-of-used-llins-in-three-cities-of-the-south-west-region-of-cameroon-4%C3%A2-years-after-the-first-national-mass-distribution-campaign
#9
Stravensky T Boussougou-Sambe, Parfait Awono-Ambene, Geraud C T Tasse, Josiane Etang, Jerome A Binyang, Lynda D Nouage, Gaston Wamba, Peter Enyong, Eric B Fokam
BACKGROUND: Long-lasting insecticidal nets (LLINs) are effective tools at reducing malaria transmission. In Cameroon, following the first national mass distribution campaign in 2011, there has been no follow up on the efficacy of LLINs distributed. The aim of this report is to assess the physical integrity and insecticidal potency of LLINs distributed in three cities with contrasting socio economic status (SES) and to evaluate the use and care for bed nets owned by individuals. METHODS: The study was conducted in Limbe, Tiko and Buea three localities in the Fako division of the South West Region of Cameroon...
January 17, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28091562/unravelling-a-simple-method-for-the-low-temperature-synthesis-of-silicon-nanocrystals-and-monolithic-nanocrystalline-thin-films
#10
Ka-Hyun Kim, Erik V Johnson, Andrey G Kazanskii, Mark V Khenkin, Pere Roca I Cabarrocas
In this work, we present new results on the plasma processing and structure of hydrogenated polymorphous silicon (pm-Si:H) thin films. pm-Si:H thin films consist of a low volume fraction of silicon nanocrystals embedded in a silicon matrix with medium range order, and they possess this morphology as a significant contribution to their growth comes from the impact on the substrate of silicon clusters and nanocrystals synthesized in the plasma. Quadrupole mass spectrometry, ion flux measurements, and material characterization by transmission electron microscopy (TEM) and atomic force microscopy all provide insight on the contribution to the growth by silicon nanocrystals during PECVD deposition...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28072757/organ-procurement-organization-survey-of-practices-and-beliefs-regarding-prerecovery-percutaneous-liver-biopsy-in-donation-after-neurologic-determination-of-death
#11
Joseph Benton Oliver, Andrea Fleisch Marcus, Mark Paster, Joseph Nespral, Advaith Bongu, George Dikdan, Lloyd Brown, Nikole Neidlinger, Baburao Koneru
BACKGROUND: Prerecovery liver biopsy (PLB) allows histological evaluation of the organ prior to procurement. The opinions and what factors might influence PLB use within Organ Procurement Organizations (OPOs) are unknown. METHODS: A survey instrument was distributed by the Association of OPOs to the clinical directors of all 58 OPOs. Descriptive statistics were calculated. Results were also stratified based on OPO characteristics. RESULTS: 84...
January 9, 2017: Transplantation
https://www.readbyqxmd.com/read/28062546/the-clinical-importance-of-quantifying-fat-distribution-during-androgen-deprivation
#12
Stephen John Foulkes, Robin M Daly, Steve Fraser
Androgen deprivation therapy (ADT) is now considered a mainstay in the treatment of metastatic and locally advanced prostate cancer (PCa). Despite well-established benefits of ADT in relation to overall survival, this treatment has been associated with a number of adverse effects, particularly with regard to key cardiometabolic risk factors including the development of insulin resistance, dyslipidaemia and increases in total and regional fat mass. In non-ADT populations, increased levels of visceral adipose tissue (VAT) are thought to be a key mediator of the increased cardiometabolic risk associated with weight gain, but this has received limited attention in men treated with ADT...
January 6, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28050871/five-micron-high-resolution-maldi-mass-spectrometry-imaging-with-simple-interchangeable-multi-resolution-optical-system
#13
Adam D Feenstra, Maria Emilia Dueñas, Young Jin Lee
High-spatial resolution mass spectrometry imaging (MSI) is crucial for the mapping of chemical distributions at the cellular and subcellular level. In this work, we improved our previous laser optical system for matrix-assisted laser desorption ionization (MALDI)-MSI, from ~9 μm practical laser spot size to a practical laser spot size of ~4 μm, thereby allowing for 5 μm resolution imaging without oversampling. This is accomplished through a combination of spatial filtering, beam expansion, and reduction of the final focal length...
January 3, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28048257/th-c-brb-01-open-source-hardware-general-overview
#14
F Therriault-Proulx
: By definition, Open Source Hardware (OSH) is "hardware whose design is made publicly available so that anyone can study, modify, distribute, make, and sell the design or hardware based on that design". The advantages of OSH are multiple and the movement has been growing exponentially over the last couple years, leading to the spread and evolution of 3D printing technologies, the creation of affordable and easy to use micro-controller boards (Arduino, Raspberry Pi, etc.), as well as a plurality of other "hands-on"/DIY projects...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047610/th-c-brb-02-open-source-medical-devices-lessons-learned-from-a-complex-collaborative-research-project
#15
S Prajapati
: By definition, Open Source Hardware (OSH) is "hardware whose design is made publicly available so that anyone can study, modify, distribute, make, and sell the design or hardware based on that design". The advantages of OSH are multiple and the movement has been growing exponentially over the last couple years, leading to the spread and evolution of 3D printing technologies, the creation of affordable and easy to use micro-controller boards (Arduino, Raspberry Pi, etc.), as well as a plurality of other "hands-on"/DIY projects...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047153/th-c-brb-00-open-source-hardware-in-medical-physics-and-its-potential-to-accelerate-innovation
#16
Francois Therriault-Proulx
: By definition, Open Source Hardware (OSH) is "hardware whose design is made publicly available so that anyone can study, modify, distribute, make, and sell the design or hardware based on that design". The advantages of OSH are multiple and the movement has been growing exponentially over the last couple years, leading to the spread and evolution of 3D printing technologies, the creation of affordable and easy to use micro-controller boards (Arduino, Raspberry Pi, etc.), as well as a plurality of other "hands-on"/DIY projects...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046962/th-c-brb-03-open-source-hardware-in-the-context-of-simple-and-widely-shared-clinical-applications
#17
J Cunha
: By definition, Open Source Hardware (OSH) is "hardware whose design is made publicly available so that anyone can study, modify, distribute, make, and sell the design or hardware based on that design". The advantages of OSH are multiple and the movement has been growing exponentially over the last couple years, leading to the spread and evolution of 3D printing technologies, the creation of affordable and easy to use micro-controller boards (Arduino, Raspberry Pi, etc.), as well as a plurality of other "hands-on"/DIY projects...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046695/mo-de-bra-03-the-ottawa-medical-physics-institute-ompi-a-practical-model-for-academic-program-collaboration-in-a-multi-centre-city
#18
M McEwen, D Rogers, P Johns/Sup
PURPOSE: To build a world-class medical physics educational program that capitalizes on expertise distributed over several clinical, government, and academic centres. Few if any of these centres would have the critical mass to solely resource a program. METHODS: In order to enable an academic program, stakeholders from five institutions made a proposal to Carleton University for a) a research network with defined membership requirements and a process for accepting new members, and b) a graduate specialization (MSc and PhD) in medical physics...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28036305/role-of-the-density-density-effect-and-mean-excitation-energy-in-solid-state-detectors-for-small-photon-fields
#19
Pedro Andreo, Hamza Benmakhlouf
A number of recent publications on small photon beam dosimetry aim at contributing to the understanding of the response of solid-state detectors in small fields. Some of them assign the difference in response to the mass density, or to the electron density, of the sensitive detector material relative to that of water. This work analyses the role of the mass and electron density ([Formula: see text]), density effect (δ) and mean excitation energy (I-value) of some detector materials in a 6 MV photon beam of 0...
February 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28032347/quantifying-uncertainty-in-estimations-of-the-total-weight-of-drugs-in-groups-of-complex-matrices-using-the-welch-satterthwaite-equation
#20
Ivo Alberink, Annette Sprong, Annabel Bolck, Peter Vergeer
In this paper, a method is described to quantify estimations of the total amount of drugs in groups of seized items, including quantification of the precision. Previous work on this topic was based on the assumptions of normally distributed measurements and grouping of items with a common relative standard deviation. In practice, these assumptions are often violated, for example, for data with point masses at 0, or if certain items in a group have a very high standard deviation. The method described in this paper is based on work by Welch and Satterthwaite and does not assume constant relative standard deviations...
December 29, 2016: Journal of Forensic Sciences
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