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von Wilebrand

K Korybalska, J Luczak, E Swora-Cwynar, A Kanikowska, N Czepulis, D Kanikowska, H Skalisz, A Breborowicz, M Grzymislawski, J Witowski
Endothelial cell dysfunction in obesity can be reduced by calorie restriction (CR), however it is unclear whether this benefit requires a concomitant weight loss or is it simply related to the reduced calorie intake per se. In our study serum was drawn from 41 obese women who were undergoing an 8-week dietary intervention with 15 - 30% energy deficit, and from 48 age- and sex-matched controls of normal weight. Serum was analysed for biomarkers of endothelial cell function, oxidative stress and inflammation...
August 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
Valdete Topçiu-Shufta, Valdete Haxhibeqiri, Luljeta Begolli, Zana Baruti-Gafurri, Shemsi Veseli, Shpend Haxhibeqiri, Ramë Miftari, Leonard Kurti, Driton Avdiu
BACKGROUND: Inflammatory and procoagulant markers are potential mediators for the cardiovascular risk in hemodialysis patients. Lipoprotein (a) [Lp(a)], is another important risk factor with inflammatory and procoagulant effects. MATERIALS AND METHODS: In 78 hemodialysis patients and 40 controls, C-reactive protein (CRP), Interleukin-6 (IL-6), lipoprotein (a) [Lp (a)], fibrinogen, D-dimer, von Wilebrand factor (vWF) and serum albumin were determined. RESULTS: CRP, IL-6, Lp(a), fibrinogen, D-dimer and vWF, were significantly higher, and serum albumin was significantly lower in patients compared to controls (24...
August 2015: Medical Archives
Senija Rašić, Almira Hadžović-Džuvo, Damir Rebić, Amina Valjevac, Snežana Unčanin
Endothelial dysfunction is associated with diabetic micro- and macroangiopathy as well as with the decline in creatinine clearance. It has been suggested that endothelial dysfunction presents in patients (pts) on continuous ambulatory peritoneal dialysis (CAPD). The objective of this study was to examine the plasma biomarkers of endothelial dysfunction and their association with IMT of carotid arteries in diabetic and non-diabetic patients on CAPD. This study included 37 CAPD pts (25 with type II diabetes and 12 non-diabetic pts) mean age 59...
August 2011: Bosnian Journal of Basic Medical Sciences
Alexandre Hertig, Christophe Ridel, Eric Rondeau
Hemolytic uremic syndrome (HUS) is related to a renal thrombotic microangiopathy, inducing hypertension and acute renal failure (ARF). Its pathogenesis involves an activation/lesion of microvascular endothelial cells, mainly in the renal vasculature, secondary to bacterial toxins, drugs, or autoantibodies. An overactivation of the complement alternate pathway secondary to a heterozygote deficiency of regulatory proteins (factor H, factor I or MCP) or to an activating mutation of factor B or C3 can also result in HUS...
July 2010: Néphrologie & Thérapeutique
Zvezdana Z Kojić
When selecting an animal species for atherosclerosis research, the most important issue is matching the model to the experiment. In choosing the atherosclerosis model there is a wide variety of choices. Genetic hyperlipidemic disorders are best studied in Watanabe rabbits and in transgenic (knockout or overexpressed) mice. Interaction between clotting disorders and atherosclerosis can be evaluated in von Wilebrand's disease swine. If hypo- or hyper-responsiveness to atherogenic stimuli is to be investigated, one should consider the pigeons...
May 2003: Srpski Arhiv za Celokupno Lekarstvo
I Peake
Carrier detection and prenatal diagnosis in the three commonest bleeding disorders (hemophilia A and B and von Wilebrands disease) can be performed either phenotypically or genotypically. Phenotypic analysis for carrier detection results only in a probabilistic assessment whereas DNA analysis, either by direct defect detection or by DNA polymorphism based gene tracking, can result in an accuracy of effectively 100%. Direct defect detection is the method of choice but can be technically demanding. Polymorphism analysis is much simpler and is now being used in family studies world wide...
1993: Southeast Asian Journal of Tropical Medicine and Public Health
D J Mancuso, E A Tuley, R Castillo, N de Bosch, P M Mannucci, J E Sadler
von Willebrand factor gene deletions were characterized in four patients with severe type III von Wilebrand disease and alloantibodies to von Willebrand factor. A PCR-based strategy was used to characterize the boundaries of the deletions. Identical 30 kb von Willebrand factor gene deletions which include exons 33 through 38 were identified in two siblings of one family by this method. A small 5 base pair insertion (CCTGG) was sequenced at the deletion breakpoint. PCR analysis was used to detect the deletion in three generations of the family, including two family members who are heterozygous for the deletion...
August 1994: Thrombosis and Haemostasis
G Baele, E Matthijs, F Barbier
F VIII activity, F VIII-related antigen and von Willebrand factor were measured in 46 patients with hepatic cirrhosis and in 30 normal individuals. These parameters were significantly higher in hepatic cirrhosis than in the controls. Linear relationships between F VIII activity and F VIII-related antigen and between F VIII-related antigen and von Willebrand factor were found in patients with hepatic cirrhosis as well as in normal individuals. However, in both groups no relationship between F VIII activity and von Willebrand factor was present...
1977: Acta Haematologica
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