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Sicca Syndrome

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https://www.readbyqxmd.com/read/29900998/beta-2-microglobulin-in-whole-unstimulated-saliva-can-effectively-distinguish-between-sj%C3%A3-gren-s-syndrome-and-non-autoimmune-sicca-symptoms
#1
Janett Riega-Torres, Guillermo Delgado-García, Julio César Salas-Alanís, Cassandra Skinner-Taylor, Lorena Pérez-Barbosa, Mario Garza-Elizondo, Celia Nohemí Sánchez-Domínguez, Luis Ángel Ceceñas-Falcón, Karim Mohamed-Noriega, Jesús Mohamed-Hamsho, David Vega-Morales
Objectives: This study aims to describe salivary beta-2 microglobulin (sB2M) levels in our setting and to assess the performance of sB2M for the diagnosis of Sjögren's syndrome (SS). Patients and methods: This cross-sectional, comparative study included 192 SS patients (2 males, 190 females; mean age 53.1 years; range 23 to 84 years) and 64 healthy controls (1 male, 63 females; mean age 46.9 years; range 21 to 82 years). Patients were divided into three groups as those with primary SS, secondary SS, and sicca non-Sjögren's syndrome (snSS)...
December 2017: Archives of Rheumatology
https://www.readbyqxmd.com/read/29882349/t-follicular-like-helper-cells-in-the-peripheral-blood-of-patients-with-primary-sj%C3%A3-gren-s-syndrome
#2
Karl A Brokstad, Marita Fredriksen, Fan Zhou, Brith Bergum, Johan G Brun, Rebecca J Cox, Kathrine Skarstein
Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease characterized by exocrine gland dysfunction, mainly causing sicca symptoms. B cells have a prominent role in SS, and the T follicular helper (TFH ) cells provide B cells with survival- and specialization signals in germinal centers. Here we investigate peripheral TFH cells in pSS. Sixteen pSS patients and healthy controls were enrolled in the study, with thirteen women and three men in each group. Whole blood was collected and separated into PBMC and plasma, followed by cryopreservation...
June 8, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29881381/current-insights-in-microbiome-shifts-in-sjogren-s-syndrome-and-possible-therapeutic-interventions
#3
REVIEW
Christina Tsigalou, Elisavet Stavropoulou, Eugenia Bezirtzoglou
Sjogren's syndrome (SS) is an autoimmune disease, among the most common ones, that targets mainly the exocrine glands as well as extra-glandular epithelial tissues. Their lymphocytic infiltration leads to manifestations from other organs (e.g., kidneys, lungs, liver, or thyroid), apart from sicca symptoms (xerostomia and keratoconjunctivitis). SS is more prevalent in women than in men (9:1). Moreover, p.SS patients are in increased risk to develop lymphoma. Certain autoantibodies (e.g., antibodies against ribonucleoprotein autoantigens Ro-SSA and La-SSB) are ultimate hallmarks for the disease...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29866668/case-of-primary-sjogren-s-syndrome-preceded-by-dystonia
#4
Kerime Ararat, Idanis Berrios, Anas Hannoun, Carolina Ionete
There are only six cases in literature that describe development of dystonia with Sjogren's syndrome (SS). We describe a case of a 43-year-old woman who presented with symptoms including movement disorder, sensory neurogenic bladder, sensory loss and neuropathic pain, migraine like headaches, musculoskeletal pain, Raynaud's phenomenon and dysautonomia. Symptoms started in 2000, with weakness that progressed to dystonia in 2003. Diagnostic work-up was inconclusive with negative inflammatory serologies, cerebrospinal fluid and MRI for many years...
June 4, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29787840/cutaneous-features-and-diagnosis-of-primary-sjogren-s-syndrome-an-update-and-review
#5
REVIEW
Preeti Jhorar, Kristin Torre, Jun Lu
Sjogren's syndrome (SS) is an autoimmune connective tissue disorder (CTD) which principally affects the lacrimal and salivary glands. Although SS is one of the three most common autoimmune CTDs alongside systemic lupus erythematosus (SLE) and progressive systemic sclerosis, it is the least researched CTD overall. SS poses a particular diagnostic challenge because it shares multiple clinical and immunologic features with other CTDs. However, there are some characteristic cutaneous clinical features that can precede the well-known sicca symptoms by years...
May 19, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29779010/low-mir200b-5p-levels-in-minor-salivary-glands-a-novel-molecular-marker-predicting-lymphoma-development-in-patients-with-sj%C3%A3-gren-s-syndrome
#6
Efstathia K Kapsogeorgou, Aristea Papageorgiou, Athanase D Protogerou, Michael Voulgarelis, Athanasios G Tzioufas
OBJECTIVES: Development of non-Hodgkin's lymphoma (NHL) is the major adverse outcome of Sjögren's syndrome (SS) affecting both morbidity and mortality. Preliminary evidence suggested that, although not deregulated compared with sicca controls, miR200b-5p levels are decreased in the minor salivary glands (MSGs) of SS patients with NHL. The aim of the current study was to evaluate the MSG expression of miR200b-5p in SS-associated NHLs and its potential predictive value for the identification of patients with SS susceptible to develop NHL...
May 19, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29754950/oral-health-related-quality-of-life-in-primary-sj%C3%A3-gren-s-syndrome
#7
Gladyz Fernández-Martínez, Víctor Zamora-Legoff, Gabriela Hernández Molina
OBJECTIVE: To assess health-related quality of life (HRQoL) and oral health-related quality of life, and correlate them with unstimulated whole salivary flow (UWSF) and oral sicca symptoms in patients with primary Sjögren's syndrome (PSS). METHODS: We included 60 patients with PSS and 60 healthy controls matched according to gender and age (±3 years). We measured the UWSF and scored the European League Against Rheumatism (EULAR) Sjögren's Syndrome Patient Reported Index (ESSPRI)...
May 10, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29745339/musculoskeletal-and-rheumatic-diseases-induced-by-immune-checkpoint-inhibitors-a-review-of-the-literature
#8
Devis Benfaremo, Lucia Manfredi, Michele Maria Luchetti, Armando Gabrielli
BACKGROUND: Immune checkpoint inhibitors are a new promising class of antitumor drugs that have been associated to a number of immune-related adverse events (AEs), including musculoskeletal and rheumatic disease. METHODS: We searched Medline reviewing reports of musculoskeletal and rheumatic AEs induced by immune checkpoint inhibitors. RESULTS: Several musculoskeletal and rheumatic AEs associated with immune checkpoint inhibitors treatment are reported in literature...
May 8, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29743147/incidence-of-sicca-syndrome-is-3-6-fold-higher-in-areas-with-farm-soils-high-in-chromium-and-nickel
#9
Ie-Bin Lian, Ie-Ran Wen, Che-Chun Su
BACKGROUND/PURPOSE: Chromium and nickel are important soil pollutants in Taiwan. Previously, we showed that blood chromium levels correlated strongly with soil chromium levels. Our observation that many patients with dry eyes or a dry mouth came from areas where soils contain high chromium levels prompted us to investigate whether incidence and prevalence of SS are higher in areas where soils contain high levels of heavy metals. METHODS: We used a database from national health insurance (NHI) to study the epidemiology of SS...
May 7, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29729452/cytokine-markers-of-b-lymphocytes-in-minor-salivary-gland-infiltrates-in-sj%C3%A3-gren-s-syndrome
#10
REVIEW
Erika P Navarro-Mendoza, David Aguirre-Valencia, Iván Posso-Osorio, Shirley Vanessa Correa-Forero, Daniel-Felipe Torres-Cutiva, Diana Loaiza, Gabriel J Tobón
Sjögren's syndrome (SS) is a chronic autoimmune disorder characterised by the clinical presence of sicca syndrome. SS compromises the dysfunction of exocrine glands due to the presence of focal, mononuclear cell infiltrates that surround the ducts and replace the secretory units. Abnormal expression of different cytokines and chemokines such as B-cell activating factor, CXC Motif Chemokine Ligand 13, interleukin 6 (IL-6), IL-22, and FMS-like tyrosine kinase 3 ligand as well as that of their corresponding receptors has been implicated in the inflammatory process...
May 3, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29670135/clinical-characteristics-and-risk-factors-for-overlapping-rheumatoid-arthritis-and-sj%C3%A3-gren-s-syndrome
#11
Huaxia Yang, Sainan Bian, Hua Chen, Li Wang, Lidan Zhao, Xuan Zhang, Yan Zhao, Xiaofeng Zeng, Fengchun Zhang
This study investigated the clinical characteristics and risk factors for overlapping rheumatoid arthritis and Sjögren's syndrome (RA/SS). Patients with RA/SS in Peking Union Medical College Hospital from January 2012 to January 2017 were retrospectively analysed and compared to those of sex- and age-matched RA or SS controls. Logistic regression analysis was used to identify risk factors. Altogether, 105 consecutive patients with RA/SS were enrolled. Ninety-seven (92.4%) of them were female, with a mean age of 51...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29662487/acquisition-of-n-glycosylation-sites-in-immunoglobulin-heavy-chain-genes-during-local-expansion-in-parotid-salivary-glands-of-primary-sj%C3%A3-gren-patients
#12
Annie Visser, Marieke E Doorenspleet, Niek de Vries, Fred K L Spijkervet, Arjan Vissink, Richard J Bende, Hendrika Bootsma, Frans G M Kroese, Nicolaas A Bos
Previous studies revealed high incidence of acquired N-glycosylation sites acquired N-glycosylation sites in RNA transcripts encoding immunoglobulin heavy variable region (IGHV) 3 genes from parotid glands of primary Sjögren's syndrome (pSS) patients. In this study, next generation sequencing was used to study the extent of ac-Nglycs among clonally expanded cells from all IGVH families in the salivary glands of pSS patients. RNA was isolated from parotid gland biopsies of five pSS patients and five non-pSS sicca controls...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29655640/how-are-ocular-signs-and-symptoms-of-dry-eye-associated-with-depression-in-women-with-and-without-sj%C3%A3-gren-s-syndrome
#13
John A Gonzales, Annie Chou, Jennifer R Rose-Nussbaumer, Vatinee Y Bunya, Lindsey A Criswell, Caroline H Shiboski, Thomas M Lietman
PURPOSE: To determine whether ocular phenotypic features of keratoconjunctivitis sicca (KCS) and/or participant-reported symptoms of dry eye disease are associated with depression in women participants enrolled in the Sjögren's International Collaborative Clinical Alliance (SICCA). DESIGN: Cross-sectional study. METHODS: Women enrolled in the SICCA registry from 9 international research sites. Participants met at least one of five inclusion criteria for registry enrollment (including complaints of dry eyes or dry mouth, a previous diagnosis of Sjögren's syndrome (SS), abnormal serology (positive anti-Sjögren's syndrome-related antigen A and/or B (anti-SSA and/or anti-SSB), or elevated anti-nuclear antibody and rheumatoid factor), bilateral parotid gland enlargement, or multiple dental caries)...
April 12, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29623391/association-between-memory-b-cells-and-clinical-and-immunological-features-of-primary-sj%C3%A3-gren-s-syndrome-and-sicca-patients
#14
Filipe Barcelos, Catarina Martins, Ana Papoila, Carlos Geraldes, Joana Cardigos, Glória Nunes, Teresa Lopes, Nuno Alves, José Vaz-Patto, Jaime Branco, Luís-Miguel Borrego
B-cells play a pivotal role in primary Sjögren's syndrome (pSS) pathogenesis. We aim to (1) evaluate the distribution of B-lymphocyte subpopulations in pSS and Sicca patients, (2) establish cut-off points that discriminate pSS from controls, (3) evaluate the association between memory B-cells and phenotypic features in pSS. We included 57 pSS patients, 68 Sicca and 24 healthy controls. Circulating B-cells were characterized by flow cytometry as naïve and memory subsets and classified from Bm1 to Bm5. Compared to controls, pSS patients had lower percentages (29...
June 2018: Rheumatology International
https://www.readbyqxmd.com/read/29610453/sj%C3%A3-gren-s-syndrome-associated-with-fanconi-s-syndrome-and-osteomalacia
#15
Jorge O Gutierrez, Maria F Zurita, Luis A Zurita
BACKGROUND Sjögren's syndrome is a chronic inflammatory autoimmune disease, which is also known as sicca syndrome, due to the symptoms of dry eyes and dry mouth, and is associated with other connective tissue diseases and autoimmune diseases. Sjögren's syndrome can also be associated with renal involvement. Fanconi's syndrome is associated with impaired reabsorption in the proximal renal tubule associated with tubulointerstitial nephritis and is associated with renal tubular acidosis and hypophosphatemia...
April 3, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29600950/diagnostic-and-predictive-evaluation-using-salivary-gland-ultrasonography-in-primary-sj%C3%A3-gren-s-syndrome
#16
Kyung-Ann Lee, Sang-Heon Lee, Hae-Rim Kim
OBJECTIVES: We aimed to assess the diagnostic accuracy of salivary gland ultrasonography (SGUS) as a single test for the detection of primary Sjögren's syndrome (pSS) and examine the prognostic factors for severe structural damage of the salivary glands based on SGUS score. METHODS: Patients with pSS (n=94) and idiopathic sicca syndrome (n=44) were evaluated using the SGUS 0-48 scoring system, which comprises five parameters: parenchymal echogenicity, homogeneity, hypoechoic areas, hyperechogenic reflections, and clearness of posterior borders...
March 16, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29529894/evaluation-of-systemic-activity-of-pediatric-primary-sj%C3%A3-gren-s-syndrome-by-eular-sj%C3%A3-gren-s-syndrome-disease-activity-index-essdai
#17
Ichiro Kobayashi, Yuka Okura, Masahiro Ueki, Yusuke Tozawa, Shunichiro Takezaki, Masafumi Yamada, Tadashi Ariga
OBJECTIVES: The purpose of this study is to evaluate systemic disease activity of pediatric Sjögren's syndrome (SS) using European League Against Rheumatism (EULAR) Sjögren's syndrome disease activity index (ESSDAI). METHODS: We retrospectively reviewed medical records of patients with SS who have been diagnosed according to 1999 Japanese diagnostic criteria for SS before 16 years old at KKR Sapporo Medical Center, Hokkaido University Hospital, and affiliated hospitals...
April 9, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29526828/controlled-release-of-an-hdac-inhibitor-for-reduction-of-inflammation-in-dry-eye-disease
#18
Michelle L Ratay, Stephen C Balmert, Ethan J Bassin, Steven R Little
Dry eye disease (DED), also known as keratoconjunctivitis sicca, is an ocular surface disease characterized by T-cell-mediated inflammation. Current therapeutics, such as immunosuppressive agents, act to suppress the clinical signs and inflammation. However, long-term usage of these treatments can cause severe side effects. In this study, we present an alternative therapeutic approach that utilizes a histone deacetylase inhibitor (HDACi) to regulate transcription of a variety of immunomodulatory genes. Specifically, HDACi have emerged as a potential anti-inflammatory agent, which can modulate the functions of a subset of suppressive T lymphocytes known as regulatory T cells (Tregs), enhancing FoxP3 acetylation and subsequently guarding the transcription factor from proteasomal degradation...
April 15, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29504848/signalling-pathways-identified-in-salivary-glands-from-primary-sj%C3%A3-gren-s-syndrome-patients-reveal-enhanced-adipose-tissue-development
#19
Lara A Aqrawi, Janicke Liaaen Jensen, Gunnvor Øijordsbakken, Ann-Kristin Ruus, Ståle Nygård, Marit Holden, Roland Jonsson, Hilde Kanli Galtung, Kathrine Skarstein
A characteristic feature of primary Sjögren's syndrome (pSS) is the destruction of salivary and lacrimal glands mediated by mononuclear cell infiltration. Adipocytes can also occupy a large portion of the salivary gland (SG) tissue area, although little is known about their significance in pSS. We have previously investigated adipose tissue infiltration in SG biopsies from pSS patients and non-SS sicca controls. Our findings indicated the distinct incidence of adipose tissue replacement in pSS patients, where adipocytes were detected in interleukin (IL) 6 rich regions...
May 2018: Autoimmunity
https://www.readbyqxmd.com/read/29486915/rescue-of-autophagy-and-lysosome-defects-in-salivary-glands-of-mrl-lpr-mice-by-a-therapeutic-phosphopeptide
#20
Baihui Li, Fengjuan Wang, Nicolas Schall, Sylviane Muller
Sjögren's syndrome is a multifactorial systemic autoimmune disorder characterized by lymphocytic infiltrates in exocrine organs. Patients present with sicca symptoms, such as extensive dry eyes and dry mouth, and parotid enlargement. Other serious complications include profound fatigue, chronic pain, major organ involvement, neuropathies and lymphomas. Current treatments only focus on relieving symptoms and do not target the origin of the disease, which is largely unknown. The question we addressed here was whether some defects exist in autophagy processes in Sjögren's syndrome and if they can be corrected or minimized using an appropriate mechanism-driven treatment targeting this central survival pathway...
June 2018: Journal of Autoimmunity
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