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Rejuvenation Research

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https://www.readbyqxmd.com/read/29765416/combating-osteoarthritis-through-stem-cell-therapies-by-rejuvenating-cartilage-a-review
#1
REVIEW
Navneet Kumar Dubey, Viraj Krishna Mishra, Rajni Dubey, Shabbir Syed-Abdul, Joseph R Wang, Peter D Wang, Win-Ping Deng
Knee osteoarthritis (OA) is a chronic degenerative disorder which could be distinguished by erosion of articular cartilage, pain, stiffness, and crepitus. Not only aging-associated alterations but also the metabolic factors such as hyperglycemia, dyslipidemia, and obesity affect articular tissues and may initiate or exacerbate the OA. The poor self-healing ability of articular cartilage due to limited regeneration in chondrocytes further adversely affects the osteoarthritic microenvironment. Traditional and current surgical treatment procedures for OA are limited and incapable to reverse the damage of articular cartilage...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29732992/current-status-of-stem-cell-therapies-in-tissue-repair-and-regeneration
#2
Tapan Kumar Giri, Amit Alexander, Mukta Agrawal, Swarnalata Saraf, Shailendra Saraf, Ajazuddin
Tissue engineering is a multi-disciplinary field such as material science, life science, and bioengineering that are necessary to make artificial tissue or rejuvenate damaged tissue. Numerous tissue repair techniques and substitute now exist even though it has several shortcomings; these shortcomings give a good reason for the continuous research for more acceptable tissue-engineered substitutes. The search for and use of a suitable stem cell in tissue engineering is a promising concept. Stem cells have a distinctive capability to differentiate and self-renew that make more suitable for cell-based therapies in tissue repair and regeneration...
May 1, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29727925/effect-of-the-construction-of-ski-runs-on-changes-in-relief-in-a-mountain-catchment-inner-carpathians-southern-poland
#3
Joanna Fidelus-Orzechowska, Dominika Wrońska-Wałach, Jarosław Cebulski, Mirosław Żelazny
In the last decade increasing popularity of winter tourism in mountain areas in Poland influenced development of ski infrastructure. This type of human activity may induce changes in mountain relief. The purpose of the study was to quantify ongoing change patterns via: (i) a determination of spatial and quantitative changes in catchment covered by new ski runs, (ii) a determination of the effect of new ski runs on the rejuvenation of relief in valleys adjacent to ski runs, (iii) an identification of changes in the surface runoff pattern before and after the construction of ski runs...
July 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29679491/ionizing-radiation-induced-acoustics-for-radiotherapy-and-diagnostic-radiology-applications
#4
Susannah Hickling, Liangzhong Xiang, Kevin C Jones, Katia Parodi, Walter Assmann, Stephen Avery, Maritza Hobson, Issam El Naqa
Acoustic waves are induced via the thermoacoustic effect in objects exposed to a pulsed beam of ionizing radiation. This phenomenon has interesting potential applications in both radiotherapy dosimetry and treatment guidance as well as low dose radiological imaging. After initial work in the field in the 1980s and early 1990s, little research was done until 2013 when interest was rejuvenated, spurred on by technological advances in ultrasound transducers and the increasing complexity of radiotherapy delivery systems...
April 21, 2018: Medical Physics
https://www.readbyqxmd.com/read/29532021/chemical-stabilization-of-perovskite-solar-cells-with-functional-fulleropyrrolidines
#5
Yao Liu, Zachariah A Page, Dongming Zhou, Volodimyr V Duzhko, Kevin R Kittilstved, Todd Emrick, Thomas P Russell
While perovskite solar cells have invigorated the photovoltaic research community due to their excellent power conversion efficiencies (PCEs), these devices notably suffer from poor stability. To address this crucial issue, a solution-processable organic chemical inhibition layer (OCIL) was integrated into perovskite solar cells, resulting in improved device stability and a maximum PCE of 16.3%. Photoenhanced self-doping of the fulleropyrrolidine mixture in the interlayers afforded devices that were advantageously insensitive to OCIL thickness, ranging from 4 to 190 nm...
February 28, 2018: ACS Central Science
https://www.readbyqxmd.com/read/29493441/environmental-training-and-synaptic-functions-in-young-and-old-brain-a-presynaptic-perspective
#6
Tommaso Bonfiglio, Matteo Vergassola, Guendalina Olivero, Anna Pittaluga
BACKGROUND: Aging is an unavoidable, physiological process that reduces the complexity and the plasticity of the synaptic contacts in central nervous system (CNS), having profound implications for human wellbeing. The term "cognitive reserve" refers to central cellular adaptations that augment the resilience of human brain to damage and aging. The term "Cognitive training" indicates the cultural, social and physical stimulations proposed as add-on therapy for the cure of central neurological diseases...
February 28, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29466069/maintaining-professional-commitment-as-a-newly-credentialed-athletic-trainer-in-the-secondary-school-setting
#7
Stephanie M Mazerolle, Sarah L Myers, Stacy E Walker, Jessica Kirby
CONTEXT:   Professional commitment, or one's affinity and loyalty to a career, has become a topic of interest in athletic training. The expanding research on the topic, however, has omitted newly credentialed athletic trainers (ATs). For an impressionable group of practitioners, transitioning to clinical practice can be stressful. OBJECTIVE:   To explore the professional commitment of newly credentialed ATs in the secondary school setting. SETTING:   Secondary school...
March 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29459901/mechanisms-and-therapeutic-targets-of-cardiac-regeneration-closing-the-age-gap
#8
REVIEW
Raphael F P Castellan, Marco Meloni
While a regenerative response is limited in the mammalian adult heart, it has been recently shown that the neonatal mammalian heart possesses a marked but transient capacity for regeneration after cardiac injury, including myocardial infarction. These findings evidence that the mammalian heart still retains a regenerative capacity and highlights the concept that the expression of distinct molecular switches (that activate or inhibit cellular mechanisms regulating tissue development and regeneration) vary during different stages of life, indicating that cardiac regeneration is an age-dependent process...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29433404/the-characteristics-of-hypoactive-sexual-desire-disorder-in-korean-women-who-visited-a-community-based-gynaecology-hospital-for-sexual-dysfunction
#9
Ho Ju Yun, Hyun Hee Cho
This cross-sectional study analysed the characteristics of HSDD (hypoactive sexual desire disorder) in Korean women. Two hundred and seventeen women seen for sexual dysfunction were assessed using the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Revised (DMS IV-TR) and the Female Sexual Function Index (FSFI). A diagnosis of HSDD was more common in women in their 40 s (56%), who had previously undergone surgery for a feeling of 'wide vagina'. Both too much or too little sexual activity caused HSDD...
February 12, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29409106/cool-atmospheric-plasma-j-plasma-and-new-options-for-facial-contouring-and-skin-rejuvenation-of-the-heavy-face-and-neck
#10
Richard D Gentile
Treating patients with heavy or thick features comes with challenges not present in those patients lacking these physical characteristics. The authors report our experience with cool atmospheric plasma for facial contouring and skin rejuvenation of the heavy face and neck including rhinophyma. Cool atmospheric plasma is generated by running helium gas over radiofrequency energy. The resulting plasma is a fourth state of matter and has enhanced clinical effects for ablation and thinning of skin and soft tissues as well of contouring and tightening of deeper soft tissues and fascia...
February 2018: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/29366690/comparative-neurotoxicity-study-of-mercury-based-inorganic-compounds-including-ayurvedic-medicines-rasasindura-and-kajjali-in-zebrafish-model
#11
Snehasis Biswas, Naay Balodia, Jayesh Bellare
Zebrafish behavioral model is a powerful tool for neuroscience research. Behavioral changes in the zebrafish are studied by administering drugs. With the aid of automated and open-source MATLAB program, high-accuracy tracking of zebrafish can be achieved, and the important behavioral parameters can be calculated. Although mercury is accepted as a potent neurotoxin, used as a key element for preparing certain Ayurvedic medicines. In this work, mercury-based inorganic compounds, including HgCl2 , HgS, and Ayurvedic medicines (Rasasindura and Kajjali) were administrated in zebrafish, and the effects on various behavioral parameters and cortisol levels were studied...
March 2018: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/29353456/in-vivo-transient-and-partial-cell-reprogramming-to-pluripotency-as-a-therapeutic-tool-for-neurodegenerative-diseases
#12
REVIEW
S Tamanini, G P Comi, S Corti
In theory, human diseases in which a specific cell type degenerates, such as neurodegenerative diseases, can be therapeutically addressed by replacement of the lost cells. The classical strategy for cell replacement is exogenous cell transplantation, but now, cell replacement can also be achieved with in situ reprogramming. Indeed, many of these disorders are age-dependent, and "rejuvenating" strategies based on cell epigenetic modifications are a possible approach to counteract disease progression...
January 20, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29302907/the-effects-of-different-aeration-strategies-on-the-performance-of-constructed-wetlands-for-phosphorus-removal
#13
Huma Ilyas, Ilyas Masih
The effects of different aeration methods such as tidal flow (TF), effluent recirculation (ER), and artificial aeration (AA) on the performance of vertical-flow constructed wetland (VFCW), horizontal-flow constructed wetland (HFCW), and hybrid constructed wetland (HCW) are extensively and critically evaluated in this review paper. Aerated constructed wetlands (CWs) demonstrate superior performance compared with non-aerated systems. The removal of total phosphorus (TP) showed substantial variation among different types of CWs and aeration strategies, with mean and standard deviation of 68 ± 20% estimated from all reviewed studies on aerated systems...
February 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29274917/autophagy-and-proteostasis-in-the-control-of-synapse-aging-and-disease
#14
REVIEW
YongTian Liang, Stephan Sigrist
The maintenance of neuronal homeostasis is severely threatened by aging, probably partially due to compromised autophagic clearance. Hence, rejuvenating autophagy in aging neurons is considered a promising strategy to restore cognitive performance. Research in recent years has shown that autophagosome biogenesis takes place mainly in distal axons and, thus, close to presynaptic specializations, and that efficient macro-autophagy is essential for neuronal homeostasis and survival. Retrograde transport of autophagosomes might play a role in neuronal signaling processes, promoting neuronal complexity and preventing neurodegeneration...
February 2018: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29216896/what-will-it-take-pathways-time-and-funding-australian-medical-students-perspective-on-clinician-scientist-training
#15
Diann S Eley, Charmaine Jensen, Ranjeny Thomas, Helen Benham
BACKGROUND: Clinician-scientists are in decline worldwide. They represent a unique niche in medicine by bridging the gap between scientific discovery and patient care. A national, integrated approach to training clinician-scientists, typically programs that comprise a comprehensive MD-PhD pathway, are customary. Such a pathway is lacking in Australia. The objective was to gather perceptions from Australian medical students on factors they perceive would influence their decision to pursue clinician-scientist training...
December 8, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29124393/the-systemic-environment-at-the-interface-of-aging-and-adult-neurogenesis
#16
REVIEW
Lucas K Smith, Charles W White, Saul A Villeda
Aging results in impaired neurogenesis in the two neurogenic niches of the adult mammalian brain, the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricle. While significant work has characterized intrinsic cellular changes that contribute to this decline, it is increasingly apparent that the systemic environment also represents a critical driver of brain aging. Indeed, emerging studies utilizing the model of heterochronic parabiosis have revealed that immune-related molecular and cellular changes in the aging systemic environment negatively regulate adult neurogenesis...
January 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29035281/young-endothelial-cells-revive-aging-blood
#17
Vivian Y Chang, Christina M Termini, John P Chute
The hematopoietic system declines with age, resulting in decreased hematopoietic stem cell (HSC) self-renewal capacity, myeloid skewing, and immune cell depletion. Aging of the hematopoietic system is associated with an increased incidence of myeloid malignancies and a decline in adaptive immunity. Therefore, strategies to rejuvenate the hematopoietic system have important clinical implications. In this issue of the JCI, Poulos and colleagues demonstrate that infusions of bone marrow (BM) endothelial cells (ECs) from young mice promoted HSC self-renewal and restored immune cell content in aged mice...
November 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29025218/regenerative-cells-for-facial-surgery-biofilling-and-biocontouring
#18
Steven R Cohen, Sierra Hewett, Lauren Ross, Flore Delaunay, Ashley Goodacre, Char Ramos, Tracy Leong, Ahmad Saad
Zuk et al in 2001 identified stem and regenerative cells within the stromal vascular fraction of fat. In preclinical studies, these cells appeared to stimulate angiogenesis and reduce inflammation, and soon thereafter, clinical use of stromal vascular fraction (SVF) evolved as researchers such as Rigotti, Coleman, Mojallal, our group, and others demonstrated that fat can be used for both therapeutic and aesthetic indications. The regenerative effects of fat and its contents on facial aesthetics have been shown at the histologic and cellular level...
July 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28993289/sirt1-and-parp1-as-epigenome-safeguards-and-micrornas-as-sasp-associated-signals-in-cellular-senescence-and-aging
#19
REVIEW
Seyedhossein Hekmatimoghaddam, Ali Dehghani Firoozabadi, Mohamad Reza Zare-Khormizi, Fatemeh Pourrajab
Cellular senescence (CS) is underlying mechanism of organism aging and is closely interconnected with age-related diseases (ARDs). Thus, any attempt that influences CS, may be undertaken to reverse or inhibit senescence, whereby could prolong healthy life span. Until now, two main proposes are epigenetic and genetic modifications of cell fate. The first one concerns rejuvenation through effective reprogramming in cells undergoing senescence, or derived from very old or progeroid patients, by which is effective in vitro in induced pluripotent stem cells (iPSCs)...
November 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28963228/advances-in-thermoelectric-materials-research-looking-back-and-moving-forward
#20
REVIEW
Jian He, Terry M Tritt
High-performance thermoelectric materials lie at the heart of thermoelectrics, the simplest technology applicable to direct thermal-to-electrical energy conversion. In its recent 60-year history, the field of thermoelectric materials research has stalled several times, but each time it was rejuvenated by new paradigms. This article reviews several potentially paradigm-changing mechanisms enabled by defects, size effects, critical phenomena, anharmonicity, and the spin degree of freedom. These mechanisms decouple the otherwise adversely interdependent physical quantities toward higher material performance...
September 29, 2017: Science
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