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Rejuvenation Research

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https://www.readbyqxmd.com/read/28550088/cardiac-telomere-length-in-heart-development-function-and-disease
#1
Scott A Booth, Fadi J Charchar
Telomeres are repetitive nucleoprotein structures at chromosome ends and a decrease in the number of these repeats, known as a reduction in telomere length (TL), triggers cellular senescence and apoptosis. Heart disease, the worldwide leading cause of death, often results from the loss of cardiac cells which could be explained by decreases in TL. Due to the cell-specific regulation of TL, this review focuses on studies that have measured telomeres in heart cells and critically assesses the relationship between cardiac TL and heart function...
May 26, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/28549948/microneedles-in-the-clinic
#2
REVIEW
Shubhmita Bhatnagar, Kaushalkumar Dave, Venkata Vamsi Krishna Venuganti
In general, there is a profound influence of reducing physical dimensions of particulates and devices on their physico-chemical and biological properties, and their performance. Reduction in the dimensions of hypodermic needle to micron-scale size has gained tremendous interest among researchers. Research efforts and publications investigating the design, development and applications of microneedles have exponentially increased in the recent years. Especially, microneedles have been widely studied and developed for cosmetic and therapeutic applications...
May 23, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28538560/buccal-fat-pad-augmentation-for-facial-rejuvenation
#3
Steven R Cohen, Emily Fireman, Sierra Hewett, Ahmad Saad
The buccal space, with its fat pad, is a valuable, overlooked target in facial rejuvenation procedures. The authors identified a specific group of patients who have normal or prominent malar projection in the presence of atrophy of the buccal fat pad, with or without prominent gonial angles. Eight of 24 prospectively studied patients (Biomedical Research Institute of America) who had fat grafts and face lifts received an average of 2.7 ml of fat transferred into the buccal space. Immediate visual correction of the buccal depression was noted...
June 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28526562/new-intracellular-activities-of-matrix-metalloproteinases-shine-in-the-moonlight
#4
REVIEW
Parker G Jobin, Georgina S Butler, ChristopherM Overall
Adaption of a single protein to perform multiple independent functions facilitates functional plasticity of the proteome allowing a limited number of protein-coding genes to perform a multitude of cellular processes. Multifunctionality is achievable by post-translational modifications and by modulating subcellular localization. Matrix metalloproteinases (MMPs), classically viewed as degraders of the extracellular matrix (ECM) responsible for matrix protein turnover, are more recently recognized as regulators of a range of extracellular bioactive molecules including chemokines, cytokines, and their binders...
May 16, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28504204/elastic-staining-an-rejuvenated-method-to-reassess-prognosis-and-serosal-invasion-in-patients-with-pt3n0m0-gastric-cancer
#5
Guang Lei, Haiyan Yang, Ting Hong, Chunhua Zhou, Jigang Li, Wenbin Liu, Jun Hu, Liang Zeng, Gong Chen, Qiong Chen, Yongchang Zhang, Nong Yang
Prognosis of pT3N0M0 gastric cancer (GC) varies greatly, though the major factor conferring poor prognosis is unclear. Subserosal elastic lamina invasion (ELI+) is closely associated with poor outcomes in pT3 colorectal cancer, but related research on GC is unavailable. This study aimed to identify the influence of ELI+ on the prognosis of patients with pT3N0M0 GC and its relationship with serosal invasion using elastic staining. We retrospectively reviewed 94 and 28 patients with pT3N0M0 and pT4aN0M0 GC who underwent gastrectomy between 1994 and 2005...
May 10, 2017: Human Pathology
https://www.readbyqxmd.com/read/28411325/a-literature-update-elucidating-production-of-panax-ginsenosides-with-a-special-focus-on-strategies-enriching-the-anti-neoplastic-minor-ginsenosides-in-ginseng-preparations
#6
REVIEW
Tanya Biswas, A K Mathur, Archana Mathur
Ginseng, an oriental gift to the world of healthcare and preventive medicine, is among the top ten medicinal herbs globally. The constitutive triterpene saponins, ginsenosides, or panaxosides are attributed to ginseng's miraculous efficacy towards anti-aging, rejuvenating, and immune-potentiating benefits. The major ginsenosides such as Rb1, Rb2, Rc, Rd., Re, and Rg1, formed after extensive glycosylations of the aglycone "dammaranediol," dominate the chemical profile of this genus in vivo and in vitro. Elicitations have successfully led to appreciable enhancements in the production of these major ginsenosides...
April 14, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28389776/senotherapy-growing-old-and-staying-young
#7
REVIEW
Roland Schmitt
Cellular senescence, which has been linked to age-related diseases, occurs during normal aging or as a result of pathological cell stress. Due to their incapacity to proliferate, senescent cells cannot contribute to normal tissue maintenance and tissue repair. Instead, senescent cells disturb the microenvironment by secreting a plethora of bioactive factors that may lead to inflammation, regenerative dysfunction and tumor progression. Recent understanding of stimuli and pathways that induce and maintain cellular senescence offers the possibility to selectively eliminate senescent cells...
April 7, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28346069/the-rationale-for-rejuvenation-research-structuring-the-debate
#8
Aubrey D N J de Grey
No abstract text is available yet for this article.
April 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28315388/mechano-devo
#9
REVIEW
Olivier Hamant
In "On growth and form", D'Arcy Wentworth Thompson (1917) stresses the inevitable interactions between physics and developmental biology. With the recent progress in molecular genetics, live imaging, micromechanics and modeling, the study of morphogenesis has been rejuvenated in the present century: the activity of developmental genes can be interpreted in terms of mechanical properties to dissect the chain of events behind shape changes; in turn, patterns of shape- and growth-derived mechanical stress are calculated and shown to act as signals controlling cell effectors, in synergy with biochemical cues, thereby channeling morphogenesis...
March 15, 2017: Mechanisms of Development
https://www.readbyqxmd.com/read/28287035/biological-basis-of-radiation-protection-needs-rejuvenation
#10
Tatjana Paunesku, Benjamin Haley, Antone Brooks, Gayle E Woloschak
PURPOSE: Human beings encounter radiation in many different situations - from proximity to radioactive waste sites to participation in medical procedures using X-rays etc. Limits for radiation exposures are legally regulated; however, current radiation protection policy does not explicitly acknowledge that biological, cellular and molecular effects of low doses and low dose rates of radiation differ from effects induced by medium and high dose radiation exposures. Recent technical developments in biology and medicine, from single cell techniques to big data computational research, have enabled new approaches for study of biology of low doses of radiation...
March 13, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28285613/ayurvedic-concept-of-shatkriyakala-a-traditional-knowledge-of-cancer-pathogenesis-and-therapy
#11
REVIEW
Ashutosh Chauhan, Deepak Kumar Semwal, Satyendra Prasad Mishra, Ruchi Badoni Semwal
The term Kriyakala refers to the recognition of the stage of a disease's progress, which helps to determine appropriate measure to correct the imbalance in Doshas (biological factors). It is a compound expression, comprised of Kriya and Kala, where Kriya means the choice to treatment (medicine, food and daily-routine) used to improve the disturbance in Doshas, and Kala refers to the stage of progress of a disease. Sushruta, an ancient Indian surgeon, has described the concept of Kriyakala in Varnaprashnadhyaya, an ancient Vedic Sanskrit text, which seeks to explain the incidence of Varnas in terms of Doshic disturbances...
March 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28185732/water-resources-management-in-the-urban-agglomeration-of-the-lake-biwa-region-japan-an-ecosystem-services-based-sustainability-assessment
#12
Xiaochen Chen, Yuqing Chen, Toshiyuki Shimizu, Jia Niu, Ken'ichi Nakagami, Xuepeng Qian, Baoju Jia, Jun Nakajima, Ji Han, Jianhua Li
An innovative ecosystem services-based sustainability assessment was conducted in the important urban agglomeration of the Lake Biwa region, Japan, covering the time period from 1950 to 2014. A 22-indicator system was established that was based on the major ecosystem services of Lake Biwa and its water courses, i.e., provisioning services regarding aquatic products and water; regulating services regarding floods and water quality; cultural services regarding recreation and tourism, scientific research, and environmental education; and supporting services regarding biodiversity...
May 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28154735/preventing-aging-with-stem-cell-rejuvenation-feasible-or-infeasible
#13
EDITORIAL
Kanya Honoki
Characterized by dysfunction of tissues, organs, organ systems and the whole organism, aging results from the reduced function of effective stem cell populations. Recent advances in aging research have demonstrated that old tissue stem cells can be rejuvenated for the purpose of maintaining the old-organ function by youthful re-calibration of the environment where stem cells reside. Biochemical cues regulating tissue stem cell function include molecular signaling pathways that interact between stem cells themselves and their niches...
January 26, 2017: World Journal of Stem Cells
https://www.readbyqxmd.com/read/28152565/sphere-induced-rejuvenation-of-swine-and-human-m%C3%A3-ller-glia-is-primarily-caused-by-telomere-elongation
#14
Ni Xu, Yao Chen, Kevin C Dean, Xiaoqin Lu, Xiao Liu, Wei Wang, Douglas C Dean, Henry J Kaplan, Ling Gao, Fangtian Dong, Yongqing Liu
Müller cells are the major supportive and protective glial cells in the retina with important functions in histogenesis and synaptogenesis during development, and in maintenance of mature neurons as they show to secrete various cytokines and manifest potentials of self-renewal and transdifferentiation into retinal neurons following injury in the vertebrate retinas. The swine retina has a visual streak structure similar to the human macular where cone photoreceptors are highly concentrated, thereby can serve as a better model for studying retinal diseases and for formulating cell-based therapeutics than the rodent retinas...
February 2, 2017: Stem Cells
https://www.readbyqxmd.com/read/28088983/the-epigenetic-basis-of-hematopoietic-stem-cell-aging
#15
REVIEW
Ashley Kramer, Grant A Challen
Highly proliferative tissues such as the gut, skin, and bone marrow lose millions of cells each day to normal attrition and challenge from different biological adversities. To achieve a lifespan beyond the longevity of individual cell types, tissue-specific stem cells sustain these tissues throughout the life of a human. For example, the lifespan of erythrocytes is about 100 days and adults make about two million new erythrocytes every second. A small pool of hematopoietic stem cells (HSCs) in the bone marrow is responsible for the lifetime maintenance of these populations...
January 2017: Seminars in Hematology
https://www.readbyqxmd.com/read/28001455/assessment-of-efficacy-and-safety-of-a-fractionated-bipolar-radiofrequency-device-for-the-treatment-of-lower-face-wrinkles-and-laxity
#16
Yueqi Jiang, Xuting Zhang, Zhong Lu, Michael H Gold
Skin aging, as a natural course, is a gradual process. It can be classified as either intrinsic or photo-aging. In recent years, as the attention to lower face wrinkles and laxity has raised significantly, the demands to facial rejuvenation also increased, along with a variety of technologies coming into being. Fractional bipolar RF as a novel means of rejuvenation has been used in clinical practice, but questions remain in terms of its efficacy and safety. Considering a large population in our country and huge demands for skin tightening, we did this research to evaluate the efficacy and safety of fractional bipolar radiofrequency...
December 21, 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/27987257/a-new-tool-to-improve-delivery-of-patient-engaged-care-and-satisfaction-in-facial-treatments-the-aesthetic-global-ranking-scale
#17
Ravi Jain, Peter Huang, Rodrigo M Ferraz
BACKGROUND: Physicians face the challenge of individualizing aesthetic treatments in order to match the aesthetic needs of patients with their expectations. OBJECTIVE: To review issues underlying patient satisfaction with minimally invasive aesthetic treatment and to present a patient-centric assessment tool (the Global Ranking Scale [GRS]) designed to set higher standards for patient consultation and treatment experience; ensure a comprehensive patient-centric aesthetic consultation process; and raise patient satisfaction with facial rejuvenation treatment...
December 16, 2016: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/27922559/botulinum-toxin-type-a-bont-a-injections-of-the-corrugator-muscles-for-aesthetics-and-depression
#18
Connie Brennan
The treatment of glabellar lines with botulinum toxin type-A (BoNT-A) is a staple for aesthetic providers who specialize in facial rejuvenation. Clinical efforts are currently underway to substantiate upper facial injections (the corrugator muscles are the target muscles) of BoNT-A as an antidepression therapy. This article describes the origin of "facial feedback" by Charles Darwin nearly 150 years ago, as well as "emotional proprioception"-2 neuroanatomical concepts that help provide the scientific rationale behind the general influence facial muscles have on the emotional centers of the brain, and, specifically, how the corrugator muscles-involved with frowning-promote a gloomy mood...
October 2016: Plastic Surgical Nursing
https://www.readbyqxmd.com/read/27854193/a-comprehensive-review-on-edible-bird-nests-and-swiftlet-farming
#19
REVIEW
Lee Suan Chua, Siti Najihah Zukefli
Edible bird's nest (EBN) is currently widely consumed by the Chinese community as tonic food and functional food, which is believed to have many medicinal benefits. Some studies have reported the biochemical compositions of EBN, graded on the basis of colour, nitrate and nitrite contents. Other studies have shown significant biological effects, while ongoing research is in progress to explore potential pharmacological applications. The high demand for EBNs in the global market has forced the local regulatory bodies to monitor swiftlet farming activities, including the EBN cleaning process...
November 2016: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27842480/mesenchymal-stem-cells-as-a-source-of-dopaminergic-neurons-a-potential-cell-based-therapy-for-parkinson-s-disease
#20
Katari Venkatesh, Dwaipayan Sen
Cell repair/replacing strategies for neurodegenerative diseases such as Parkinson's disease depend on well-characterized dopaminergic neuronal candidates that are healthy and show promising effect in the rejuvenation of degenerated area of the brain. Therefore, it is imperative to develop innovative therapeutic strategies that replace damaged neurons with new/functional dopaminergic neurons. Although several research groups have reported the generation of neural precursors/neurons from human/mouse embryonic stem cells and mesenchymal stem cells, the latter is considered to be an attractive therapeutic candidate because of its high capacity for self-renewable, no adverse effect to allogeneic versus autologous transplants, high ethical acceptance and no teratoma formation...
November 14, 2016: Current Stem Cell Research & Therapy
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