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Diet transcriptome

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https://www.readbyqxmd.com/read/29789429/brown-adipose-tissue-development-and-function-and-its-impact-on-reproduction
#1
M E Symonds, Peter Aldiss, Neele Dellschaft, James Law, Hernan Fainberg, Mark Pope, Harold Sacks, Helen Budge
Although brown adipose tissue (BAT) is one of the smallest organs in the body, it has the potential to have a substantial impact on both heat production as well as fat and carbohydrate metabolism. This is most apparent at birth which is characterised with the rapid appearance and activation of the BAT specific mitochondrial uncoupling protein (UCP)1 in many large mammals. The amount of brown fat then gradually declines with age, an adaptation that can be modulated by the thermal environment. Given the increased incidence of maternal obesity and its potential transmission to the mother's offspring, increasing BAT activity in the mother could be one mechanism to prevent this cycle...
May 22, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29769440/elevated-hepatic-expression-of-h19-long-noncoding-rna-contributes-to-diabetic-hyperglycemia
#2
Na Zhang, Tingting Geng, Zhangsheng Wang, Ruling Zhang, Tiefeng Cao, Joao Paulo Camporez, Shi-Ying Cai, Ya Liu, Luisa Dandolo, Gerald I Shulman, Gordon G Carmichael, Hugh S Taylor, Yingqun Huang
Excessive hepatic glucose production (HGP) contributes significantly to the hyperglycemia of type 2 diabetes; however, the molecular mechanism underlying this dysregulation remains poorly understood. Here, we show that fasting temporally increases the expression of H19 long noncoding RNA (lncRNA) in nondiabetic mouse liver, whereas its level is chronically elevated in diet-induced diabetic mice, consistent with the previously reported chronic hepatic H19 increase in diabetic patients. Importantly, liver-specific H19 overexpression promotes HGP, hyperglycemia, and insulin resistance, while H19 depletion enhances insulin-dependent suppression of HGP...
May 17, 2018: JCI Insight
https://www.readbyqxmd.com/read/29765519/long-noncoding-rnas-are-associated-with-metabolic-and-cellular-processes-in-the-jejunum-mucosa-of-pre-weaning-calves-in-response-to-different-diets
#3
Rosemarie Weikard, Frieder Hadlich, Harald M Hammon, Doerte Frieten, Caroline Gerbert, Christian Koch, Georg Dusel, Christa Kuehn
Long noncoding RNAs (lncRNAs) emerged as important regulatory component of mechanisms involved in gene expression, chromatin modification and epigenetic processes, but they are rarely annotated in the bovine genome. Our study monitored the jejunum transcriptome of German Holstein calves fed two different milk diets using transcriptome sequencing (RNA-seq). To identify potential lncRNAs within the pool of unknown transcripts, four bioinformatic lncRNA prediction tools were applied. The intersection of the alignment-free lncRNA prediction tools (CNCI, PLEK and FEELnc) predicted 1,812 lncRNA transcripts concordantly comprising a catalogue of 1,042 putative lncRNA loci expressed in the calves' intestinal mucosa...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29763587/mice-exposed-to-bisphenol-a-exhibit-depressive-like-behavior-with-neurotransmitter-and-neuroactive-steroid-dysfunction
#4
Frances Xin, Erin Fischer, Christopher Krapp, Elizabeth N Krizman, Yemin Lan, Clementina Mesaros, Nathaniel W Snyder, Amita Bansal, Michael B Robinson, Rebecca A Simmons, Marisa S Bartolomei
Fetal exposure to endocrine disrupting chemicals (EDCs) has been associated with adverse neurobehavioral outcomes across the lifespan and can persist across multiple generations of offspring. However, the underlying mechanisms driving these changes are not well understood. We investigated the molecular perturbations associated with EDC-induced behavioral changes in first (F1) and second (F2) filial generations, using the model EDC bisphenol A (BPA). C57BL/6J dams were exposed to BPA from preconception until lactation through the diet at doses (10 μg/kg bw/d-lower dose or 10 mg/kg bw/d-upper dose) representative of human exposure levels...
May 18, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29762555/global-transcriptome-analysis-identifies-weight-regain-induced-activation-of-adaptive-immune-responses-in-white-adipose-tissue-of-mice
#5
D S Kyung, H R Sung, Y J Kim, K D Kim, S Y Cho, J H Choi, Y-H Lee, I Y Kim, J K Seong
OBJECTIVE: Studies have indicated that weight regain following weight loss predisposes obese individuals to metabolic disorders; however, the molecular mechanism of this potential adverse effect of weight regain is not fully understood. Here we investigated global transcriptome changes and the immune response in mouse white adipose tissue caused by weight regain. DESIGN: We established a diet switch protocol to compare the effects of weight regain with those of weight gain without precedent weight loss, weight loss maintenance and chow diet...
December 7, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29753678/deficiency-of-fibroblast-growth-factor-21-fgf21-promotes-hepatocellular-carcinoma-hcc-in-mice-on-a-long-term-obesogenic-diet
#6
Garima Singhal, Gaurav Kumar, Suzanne Chan, Ffolliott M Fisher, Yong Ma, Hilde G Vardeh, Imad A Nasser, Jeffrey S Flier, Eleftheria Maratos-Flier
OBJECTIVE: Non-alcoholic fatty liver (NAFL) associated with obesity is a major cause of liver diseases which can progress to non-alcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma (HCC). Fibroblast growth factor 21 (FGF21) plays an important role in liver metabolism and is also a potential marker for NAFL. Here we aimed to test the effect of FGF21 deficiency on liver pathology in mice consuming a conventional high fat, high sucrose (HFHS) obesogenic diet for up to 52 weeks...
March 8, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29692426/transcriptomic-analysis-of-the-liver-of-cholesterol-fed-rabbits-reveals-altered-hepatic-lipid-metabolism-and-inflammatory-response
#7
Weirong Wang, Yulong Chen, Liang Bai, Sihai Zhao, Rong Wang, Baoning Liu, Yali Zhang, Jianglin Fan, Enqi Liu
Rabbits are a suitable animal model for atherosclerosis due to their sensitivity to dietary cholesterol. Moreover, rabbits have lipoprotein profiles that are more similar to humans than those of other laboratory animals. However, little is known about the transcriptomic information related to atherosclerosis in rabbits. We aimed to determine the changes in the livers of rabbits fed a normal chow diet (control) or high cholesterol diet (HCD) by histological examinations and RNA sequencing analysis. Compared with the control group, the lipid levels and small LDL subfractions in plasma were increased, and aortic atherosclerotic plaques were formed in the HCD group...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29678171/analysis-of-hepatic-transcriptome-demonstrates-altered-lipid-metabolism-following-lactobacillus-johnsonii-bs15-prevention-in-chickens-with-subclinical-necrotic-enteritis
#8
Xiaodan Qing, Dong Zeng, Hesong Wang, Xueqin Ni, Jing Lai, Lei Liu, Abdul Khalique, Kangcheng Pan, Bo Jing
BACKGROUND: Subclinical necrotic enteritis (SNE) widely outbreaks in chickens which inflicted growth-slowing, causing enormous social and economic burdens. To better understand the molecular underpinnings of SNE on lipid metabolism and explore novel preventative strategies against SNE, we studied the regulatory mechanism of a potential probiotic, Lactobacillus johnsonii BS15 on the lipid metabolism pathways involved in chickens with SNE. METHODS: One hundred eighty one-day-old chickens were randomly divided into three groups and arranged with basal diet (control and SNE group)...
April 20, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29669315/characterization-and-analysis-of-whole-transcriptome-of-giant-panda-spleens-implying-critical-roles-of-long-non-coding-rnas-in-immunity
#9
Rui Peng, Yuliang Liu, Zhigang Cai, Fujun Shen, Jiasong Chen, Rong Hou, Fangdong Zou
BACKGROUND/AIMS: Giant pandas, an endangered species, are a powerful symbol of species conservation. Giant pandas may suffer from a variety of diseases. Owing to their highly specialized diet of bamboo, giant pandas are thought to have a relatively weak ability to resist diseases. The spleen is the largest organ in the lymphatic system. However, there is little known about giant panda spleen at a molecular level. Thus, clarifying the regulatory mechanisms of spleen could help us further understand the immune system of the giant panda as well as its conservation...
April 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29661852/integrated-transcriptomic-and-proteomic-analyses-suggest-the-participation-of-endogenous-protease-inhibitors-in-the-regulation-of-protease-gene-expression-in-helicoverpa-armigera
#10
Purushottam R Lomate, Veena Dewangan, Neha Mahajan, Yashwant Kumar, Abhijeet Kulkarni, Li Wang, Smita Saxsena, Vidya S Gupta, Ashok P Giri
Insects adapt to plant protease inhibitors (PIs) present in their diet by differentially regulating multiple digestive proteases. However, mechanisms regulating protease gene expression in insects are largely enigmatic. Ingestion of multi-domain recombinant Capsicum annuum protease inhibitor-7 (CanPI-7) arrests growth and development of Helicoverpa armigera (Lepidoptera: Noctuidae). Using de novo RNA sequencing and proteomic analysis, we examined the response of H. armigera larvae fed on recombinant CanPI-7 at different time intervals...
April 16, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29656123/selenium-supplementation-prevents-metabolic-and-transcriptomic-responses-to-cadmium-in-mouse-lung
#11
Xin Hu, Joshua D Chandler, Jolyn Fernandes, Michael L Orr, Li Hao, Karan Uppal, David C Neujahr, Dean P Jones, Young-Mi Go
BACKGROUND: The protective effect of selenium (Se) on cadmium (Cd) toxicity is well documented, but underlying mechanisms are unclear. METHODS: Male mice fed standard diet were given Cd (CdCl2 , 18 μmol/L) in drinking water with or without Se (Na2 SeO4, 20 μmol/L) for 16 weeks. Lungs were analyzed for Cd concentration, transcriptomics and metabolomics. Data were analyzed with biostatistics, bioinformatics, pathway enrichment analysis, and combined transcriptome-metabolome-wide association study...
April 12, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29649537/anti-obesity-effects-and-changes-of-colonic-transcriptome-by-sodium-alginate-on-high-fat-diet-induced-obese-mice
#12
Xiong Wang, Fang Liu, Yuan Gao, Chang-Hu Xue, R W Li, Qing-Juan Tang
Human obesity and overweight, caused by accumulated of fat, is the most commonly phenomenon from all over the world, especially in Western countries and Chinese mainland during the past three decades. Sodium Alginate, a polysaccharide extracted from brown seaweeds, has been proved its strong ability on body weight loss and anti-inflammatory response. However, no studies have been explored the effects of Sodium Alginate on colonic transcriptome, especially in obese individuals. Therefore, the current study was designed to detect whether Sodium Alginate could remit obesity and ease chronic metabolism disease through strengthening the bio-functionality of the lower intestine, particularly in colon...
April 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29649482/phylogeny-and-evolution-of-the-cholesterol-transporter-npc1-in-insects
#13
Jin-Cheng Zheng, Shao-Lei Sun, Xiao-Rong Yue, Tong-Xian Liu, Xiangfeng Jing
Sterols are essential nutrients for eukaryotes. Insects are obligate sterol auxotrophs and must acquire this key nutrient from their diets. The digestive tract is the organ for absorbing nutrients as well as sterols from food. In mice, the Niemann-Pick type C1 Like 1 (NPC1L1) gene is highly expressed in the intestine and is critical for cholesterol absorption. In contrast, the molecular mechanisms for the absorption of dietary sterols in insects have not been well studied. We annotated NPC1 genes in 39 insects from 10 orders using available genomic and transcriptomic information and inferred phylogenetic relationships...
April 9, 2018: Journal of Insect Physiology
https://www.readbyqxmd.com/read/29642802/effect-of-high-fat-diet-on-immature-female-mice-and-messenger-and-noncoding-rna-expression-profiling-in-ovary-and-white-adipose-tissue
#14
Bin-Bin Huang, Xiao-Chun Liu, Xiao-Yun Qin, Jie Chen, Pei-Gen Ren, Wei-Fen Deng, Jian Zhang
Obesity is a chronic multifactorial disease prevalent in many areas of the world and is a major cause of morbidity and mortality. In women, obesity increases the risks of both metabolic and reproductive diseases, such as diabetes and infertility. The mechanisms underlying these effects, especially in young women, are largely unknown. To explore these mechanisms, we established a high-fat diet (HFD) model of obesity in immature female mice. Microarray analysis of gene expression in ovaries and white adipose tissue identified a large number of differentially expressed genes (>1...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29642370/global-transcriptome-analysis-of-brown-adipose-tissue-of-diet-induced-obese-mice
#15
Jingyi Cao, Qi Zhu, Lin Liu, Bradley J Glazier, Benjamin C Hinkel, Chun Liang, Haifei Shi
Consumption of a high-fat diet (HFD) promotes the development of obesity, a disease resulting from an imbalance between energy intake and energy expenditure. Brown adipose tissue (BAT) has thermogenic capacity that burns calories to produce heat, and it is a potential target for the treatment and prevention of obesity. There is limited information regarding the impact of HFD on the BAT transcriptome. We hypothesized that HFD-induced obesity would lead to transcriptional regulation of BAT genes. RNA sequencing was used to generate global transcriptome profiles from BAT of lean mice fed with a low-fat diet (LFD) and obese mice fed with a HFD...
April 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29628048/comprehensive-study-of-rodent-olfactory-tissue-lipid-composition
#16
Anne Marie Le Bon, Nicolas Deprêtre, Estelle Sibille, Stéphanie Cabaret, Stéphane Grégoire, Vanessa Soubeyre, Elodie Masson, Niyazi Acar, Lionel Bretillon, Xavier Grosmaitre, Olivier Berdeaux
The peripheral olfactory tissue (OT) plays a primordial role in the detection and transduction of olfactory information. Recent proteomic and transcriptomic studies have provided valuable insight into proteins and RNAs expressed in this tissue. Paradoxically, there is little information regarding the lipid composition of mammalian OT. To delve further into this issue, using a set of complementary state-of-the-art techniques, we carried out a comprehensive analysis of OT lipid composition in rats and mice fed with standard diets...
April 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29618786/toxigenic-effects-of-two-benthic-diatoms-upon-grazing-activity-of-the-sea-urchin-morphological-metabolomic-and-de-novo-transcriptomic-analysis
#17
Nadia Ruocco, Susan Costantini, Valerio Zupo, Chiara Lauritano, Davide Caramiello, Adrianna Ianora, Alfredo Budillon, Giovanna Romano, Genoveffa Nuzzo, Giuliana D'Ippolito, Angelo Fontana, Maria Costantini
Diatoms are unicellular algae playing a key role as photosynthetic organisms in the world's ocean food webs. The chemical ecology of planktonic diatoms is well documented, but few studies have reported on the effects of benthic diatoms on their consumers, also due to difficulties in the collection, quantification and massive culturing of benthic species. Here for the first time we investigate the effects of feeding on two abundantly occurring benthic diatoms, Nanofrustulum shiloi and Cylindrotheca closterium, isolated from the leaves of the seagrass Posidonia oceanica, on the sea urchin Paracentrotus lividus...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29618549/the-role-of-ecological-factors-in-shaping-bat-cone-opsin-evolution
#18
Eduardo de A Gutierrez, Ryan K Schott, Matthew W Preston, Lívia O Loureiro, Burton K Lim, Belinda S W Chang
Bats represent one of the largest and most striking nocturnal mammalian radiations, exhibiting many visual system specializations for performance in light-limited environments. Despite representing the greatest ecological diversity and species richness in Chiroptera, Neotropical lineages have been undersampled in molecular studies, limiting the potential for identifying signatures of selection on visual genes associated with differences in bat ecology. Here, we investigated how diverse ecological pressures mediate long-term shifts in selection upon long-wavelength ( Lws ) and short-wavelength ( Sws1 ) opsins, photosensitive cone pigments that form the basis of colour vision in most mammals, including bats...
April 11, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29618337/gene-co-expression-networks-in-liver-and-muscle-transcriptome-reveal-sex-specific-gene-expression-in-lambs-fed-with-a-mix-of-essential-oils
#19
Marcella Sabino, Victor Adriano Okstoft Carmelo, Gianluca Mazzoni, Katia Cappelli, Stefano Capomaccio, Paolo Ajmone-Marsan, Andrea Verini-Supplizi, Massimo Trabalza-Marinucci, Haja N Kadarmideen
BACKGROUND: Essential oil (EO) dietary supplementation is a new strategy to improve animal health. EO compounds have antiparasitic, antimicrobial, antiviral, antimycotic, antioxidant and anti-inflammatory proprieties. Nutrigenomics investigations represent innovative approaches in understanding the relation between diet effect and gene expression related to the animal performance. Few nutrigenomics studies have used a high-throughput RNA-Sequencing (RNA-Seq) approach, despite great potential of RNA-Seq data in gene expression quantification and in co-expression network analyses...
April 4, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29617714/transcriptome-profiling-of-genes-involving-in-carotenoid-biosynthesis-and-accumulation-between-leaf-and-root-of-carrot-daucus-carota-l
#20
Jing Ma, Jingwen Li, Zhisheng Xu, Feng Wang, Aisheng Xiong
Carrot provides abundant carotenoid for human diet and is one of the most widely cultivated root vegetables in the world. However, the absence of the tissue-specific transcriptome of carrots hampers the investigation of the association of secondary metabolic mechanism with the different tissue types. In this study, we obtained 46,119,008/48,414,508 raw reads and 45,394,846/47,887,648 clean reads from the carrot leaf and root, respectively. Moreover, α- and β-carotene were found to accumulate in both tissues...
March 29, 2018: Acta Biochimica et Biophysica Sinica
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