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Diet transcriptome

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https://www.readbyqxmd.com/read/27916986/pharmacological-modulation-of-lmna-srsf1-dependent-splicing-abrogates-diet-induced-obesity-in-mice
#1
J Santo, C Lopez-Herrera, C Apolit, Y Bareche, L Lapasset, C Chavey, S Capozi, F Mahuteau, R Najman, P Fornarelli, I C Lopez-Mejía, G Béranger, F Casas, E-Z Amri, B Pau, D Scherrer, J Tazi
BAKGROUND/OBJECTIVES: Intense drug discovery efforts in the metabolic field highlight the need for novel strategies for the treatment of obesity. Alternative splicing (AS) and/or polyadenylation enable the LMNA gene to express distinct protein isoforms that exert opposing effects on energy metabolism and lifespan. Here we aimed to use the splicing factor SRSF1 that contribute to the production of these different isoforms as a target to uncover new anti-obesity drug. SUBJECTS/METHODS: Small molecules modulating SR protein activity and splicing, were tested for their abilities to interact with SRSF1 and to modulate LMNA (AS)...
December 5, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27898676/dietary-butyrate-helps-to-restore-the-intestinal-status-of-a-marine-teleost-sparus-aurata-fed-extreme-diets-low-in-fish-meal-and-fish-oil
#2
Itziar Estensoro, Gabriel Ballester-Lozano, Laura Benedito-Palos, Fabian Grammes, Juan Antonio Martos-Sitcha, Liv-Torunn Mydland, Josep Alvar Calduch-Giner, Juan Fuentes, Vasileios Karalazos, Álvaro Ortiz, Margareth Øverland, Ariadna Sitjà-Bobadilla, Jaume Pérez-Sánchez
There is a constant need to find feed additives that improve health and nutrition of farmed fish and lessen the intestinal inflammation induced by plant-based ingredients. The objective of this study was to evaluate the effects of adding an organic acid salt to alleviate some of the detrimental effects of extreme plant-ingredient substitution of fish meal (FM) and fish oil (FO) in gilthead sea bream diet. Three experiments were conducted. In a first trial (T1), the best dose (0.4%) of sodium butyrate (BP-70 ®NOREL) was chosen after a short (9-weeks) feeding period...
2016: PloS One
https://www.readbyqxmd.com/read/27892926/dual-specificity-phosphatase-6-deficiency-regulates-gut-microbiome-and-transcriptome-response-against-diet-induced-obesity-in-mice
#3
Jhen-Wei Ruan, Sarah Statt, Chih-Ting Huang, Yi-Ting Tsai, Cheng-Chin Kuo, Hong-Lin Chan, Yu-Chieh Liao, Tse-Hua Tan, Cheng-Yuan Kao
The gut microbiota plays profound roles in host metabolism and the inflammatory response associated with the development of obesity. Dusp6-deficient mice have been shown to be resistant to diet-induced obesity, but the mechanism behind this remains unclear. 16S ribosomal RNA gene analysis demonstrated that dusp6-deficient mice harbour unique gut microbiota with resistance to diet-induced-obesity-mediated alteration of the gut microbiome. Using a germ-free mouse model, we found that faecal/gut microbiota derived from dusp6-deficient mice significantly increased energy expenditure and reduced weight gain in recipient wild-type mice fed on a high-fat diet...
November 28, 2016: Nature Microbiology
https://www.readbyqxmd.com/read/27881825/effects-of-a-gut-pathobiont-in-a-gnotobiotic-mouse-model-of-childhood-undernutrition
#4
Vitas E Wagner, Neelendu Dey, Janaki Guruge, Ansel Hsiao, Philip P Ahern, Nicholas P Semenkovich, Laura V Blanton, Jiye Cheng, Nicholas Griffin, Thaddeus S Stappenbeck, Olga Ilkayeva, Christopher B Newgard, William Petri, Rashidul Haque, Tahmeed Ahmed, Jeffrey I Gordon
To model how interactions among enteropathogens and gut microbial community members contribute to undernutrition, we colonized gnotobiotic mice fed representative Bangladeshi diets with sequenced bacterial strains cultured from the fecal microbiota of two 24-month-old Bangladeshi children: one healthy and the other underweight. The undernourished donor's bacterial collection contained an enterotoxigenic Bacteroides fragilis strain (ETBF), whereas the healthy donor's bacterial collection contained two nontoxigenic strains of B...
November 23, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27877090/genetic-variant-in-flavin-containing-monooxygenase-3-alters-lipid-metabolism-in-laying-hens-in-a-diet-specific-manner
#5
Jing Wang, Cheng Long, Haijun Zhang, Yanan Zhang, Hao Wang, Hongyuan Yue, Xiaocui Wang, Shugeng Wu, Guanghai Qi
Genetic variant T329S in flavin-containing monooxygenase 3 (FMO3) impairs trimethylamine (TMA) metabolism in birds. The TMA metabolism that under complex genetic and dietary regulation, closely linked to cardiovascular disease risk. We determined whether the genetic defects in TMA metabolism may change other metabolic traits in birds, determined whether the genetic effects depend on diets, and to identify genes or gene pathways that underlie the metabolic alteration induced by genetic and diet factors. We used hens genotyped as FMO3 c...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27873093/fatty-acids-in-a-high-fat-diet-potentially-induce-gastric-parietal-cell-damage-and-metaplasia-in-mice
#6
Yuki Hirata, Takuhito Sezaki, Miwa Tamura-Nakano, Chinatsu Oyama, Teruki Hagiwara, Takamasa Ishikawa, Shinji Fukuda, Kazuhiko Yamada, Kazuhide Higuchi, Taeko Dohi, Yuki I Kawamura
BACKGROUND: Obesity is associated with risk of adenocarcinoma in the proximal stomach. We aimed to identify the links between dietary fat and gastric premalignant lesions. METHODS: C57BL/6 mice were fed high fat diet (HFD), and gastric mucosa was histologically analysed. Morphological changes were also analysed using an electron microscope. Transcriptome analysis of purified parietal cells was performed, and non-parietal gastric corpus epithelial cells were subjected to single-cell gene-expression profiling...
November 21, 2016: Journal of Gastroenterology
https://www.readbyqxmd.com/read/27870856/dietary-intake-influences-adult-fertility-and-offspring-fitness-in-zebrafish
#7
Trent Newman, Noel Jhinku, Michael Meier, Julia Horsfield
The burden of malnutrition, including both over- and undernutrition, is a major public health concern. Here we used a zebrafish model of diet-induced obesity to analyze the impact of dietary intake on fertility and the phenotype of the next generation. Over an eight-week period, one group received 60 mg of food each day (60 mg arm), while another received 5 mg (5 mg arm). At the end of the diet, the body mass index of the 60 mg arm was 1.5 fold greater than the 5 mg arm. The intervention also had a marked impact on fertility; breeding success and egg production in the 60 mg arm were increased 2...
2016: PloS One
https://www.readbyqxmd.com/read/27863544/effect-of-a-post-weaning-diet-supplemented-with-functional-feed-additives-on-ileal-transcriptome-activity-and-serum-cytokines-in-piglets-challenged-with-lipopolysaccharide
#8
N Bissonnette, X R Jiang, J J Matte, F Guay, G Talbot, V Bontempo, J Gong, Q Wang, M Lessard
This study evaluated the potential of a weanling diet supplemented with trace minerals, vitamins, prebiotics, essential oils, antioxidants and bovine colostrum (BC) to modulate the inflammatory response of low-weight (LW) and high-weight (HW) piglets challenged with lipopolysaccharide (LPS). At weaning (20±1 d), litters from 32 sows were assigned to four groups: control diet (CTL), CTL plus dietary supplements (DS) or the antibiotic chlortetracycline (ATB), or DS plus BC in place of plasma proteins in the weanling diet (DS+BC)...
December 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27851833/deciphering-the-soybean-molecular-stress-response-via-high-throughput-approaches
#9
Agata Tyczewska, Joanna Gracz, Jakub Kuczyński, Tomasz Twardowski
As a result of thousands of years of agriculture, humans had created many crop varieties that became the basis of our daily diet, animal feed and also carry industrial application. Soybean is one of the most important crops worldwide and because of its high economic value the demand for soybean products is constantly growing. In Europe, due to unfavorable climate conditions, soybean cultivation is restricted and we are forced to rely on imported plant material. The development of agriculture requires continuous improvements in quality and yield of crop varieties under changing or adverse conditions, namely stresses...
November 17, 2016: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/27824139/rna-seq-analyses-of-the-midgut-from-blood-and-serum-fed-ixodes-ricinus-ticks
#10
Jan Perner, Jan Provazník, Jana Schrenková, Veronika Urbanová, José M C Ribeiro, Petr Kopáček
Adult females of the genus Ixodes imbibe blood meals exceeding about 100 times their own weight within 7‒9 days. During this period, ticks internalise components of host blood by endocytic digest cells that line the tick midgut epithelium. Using RNA-seq, we aimed to characterise the midgut transcriptome composition in adult Ixodes ricinus females during early and late phase of engorgement. To address specific adaptations to the haemoglobin-rich diet, we compared the midgut transcriptomes of genetically homogenous female siblings fed either bovine blood or haemoglobin-depleted serum...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27807042/mice-fed-a-high-fat-diet-supplemented-with-resistant-starch-display-marked-shifts-in-the-liver-metabolome-concurrent-with-altered-gut-bacteria
#11
Dorothy A Kieffer, Brian D Piccolo, Maria L Marco, Eun Bae Kim, Michael L Goodson, Michael J Keenan, Tamara N Dunn, Knud Erik Bach Knudsen, Roy J Martin, Sean H Adams
BACKGROUND: High-amylose-maize resistant starch type 2 (HAMRS2) is a fermentable dietary fiber known to alter the gut milieu, including the gut microbiota, which may explain the reported effects of resistant starch to ameliorate obesity-associated metabolic dysfunction. OBJECTIVE: Our working hypothesis was that HAMRS2-induced microbiome changes alter gut-derived signals (i.e., xenometabolites) reaching the liver via the portal circulation, in turn altering liver metabolism by regulating gene expression and other pathways...
November 2, 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27806685/prepartum-body-condition-score-and-plane-of-nutrition-affect-the-hepatic-transcriptome-during-the-transition-period-in-grazing-dairy-cows
#12
M Vailati-Riboni, S Meier, C R Burke, J K Kay, M D Mitchell, C G Walker, M A Crookenden, A Heiser, S L Rodriguez-Zas, J R Roche, J J Loor
BACKGROUND: A transcriptomic approach was used to evaluate potential interactions between prepartum body condition score (BCS) and feeding management in the weeks before calving on hepatic metabolism during the periparturient period. METHODS: Thirty-two mid-lactation grazing dairy cows of mixed age and breed were randomly allocated to one of four treatment groups in a 2 × 2 factorial arrangement: two prepartum BCS categories [4.0 (thin, BCS4) and 5.0 (optimal, BCS5); based on a 10-point scale], and two levels of energy intake during the 3 weeks preceding calving (75 and 125 % of estimated requirements)...
November 2, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27802136/a-yy1-dependent-increase-in-aerobic-metabolism-is-indispensable-for-intestinal-organogenesis
#13
Namit Kumar, Manasa Srivillibhuthur, Shilpy Joshi, Katherine D Walton, Anbo Zhou, William J Faller, Ansu O Perekatt, Owen J Sansom, Deborah L Gumucio, Jinchuan Xing, Edward M Bonder, Nan Gao, Eileen White, Michael P Verzi
During late gestation, villi extend into the intestinal lumen to dramatically increase the surface area of the intestinal epithelium, preparing the gut for the neonatal diet. Incomplete development of the intestine is the most common gastrointestinal complication in neonates, but the causes are unclear. We provide evidence in mice that Yin Yang 1 (Yy1) is crucial for intestinal villus development. YY1 loss in the developing endoderm had no apparent consequences until late gestation, after which the intestine differentiated poorly and exhibited severely stunted villi...
October 15, 2016: Development
https://www.readbyqxmd.com/read/27799288/loss-of-nat4-and-its-associated-histone-h4-n-terminal-acetylation-mediates-calorie-restriction-induced-longevity
#14
Diego Molina-Serrano, Vassia Schiza, Christis Demosthenous, Emmanouil Stavrou, Jan Oppelt, Dimitris Kyriakou, Wei Liu, Gertrude Zisser, Helmut Bergler, Weiwei Dang, Antonis Kirmizis
Changes in histone modifications are an attractive model through which environmental signals, such as diet, could be integrated in the cell for regulating its lifespan. However, evidence linking dietary interventions with specific alterations in histone modifications that subsequently affect lifespan remains elusive. We show here that deletion of histone N-alpha-terminal acetyltransferase Nat4 and loss of its associated H4 N-terminal acetylation (N-acH4) extend yeast replicative lifespan. Notably, nat4Δ-induced longevity is epistatic to the effects of calorie restriction (CR)...
December 2016: EMBO Reports
https://www.readbyqxmd.com/read/27798657/the-met-receptor-tyrosine-kinase-confers-repair-of-murine-pancreatic-acinar-cells-following-acute-and-chronic-injury
#15
Ivana Gaziova, Daniel Jackson, Paul J Boor, Dwayne Carter, Zobeida Cruz-Monserrate, Cornelis J Elferink, Aditya D Joshi, Bhupendra Kaphalia, Craig D Logsdon, Karen Pereira de Castro, Lynn Soong, Xinrong Tao, Suimin Qiu, Lisa A Elferink
Acinar cells represent the primary target in necroinflammatory diseases of the pancreas, including pancreatitis. The signaling pathways guiding acinar cell repair and regeneration following injury remain poorly understood. The purpose of this study was to determine the importance of Hepatocyte Growth Factor Receptor/MET signaling as an intrinsic repair mechanism for acinar cells following acute damage and chronic alcohol-associated injury. Here, we generated mice with targeted deletion of MET in adult acinar cells (MET-/-)...
2016: PloS One
https://www.readbyqxmd.com/read/27798344/obese-mice-fed-a-diet-supplemented-with-enzyme-treated-wheat-bran-display-marked-shifts-in-the-liver-metabolome-concurrent-with-altered-gut-bacteria
#16
Dorothy A Kieffer, Brian D Piccolo, Maria L Marco, Eun Bae Kim, Michael L Goodson, Michael J Keenan, Tamara N Dunn, Knud Erik Bach Knudsen, Sean H Adams, Roy J Martin
BACKGROUND: Enzyme-treated wheat bran (ETWB) contains a fermentable dietary fiber previously shown to decrease liver triglycerides (TGs) and modify the gut microbiome in mice. It is not clear which mechanisms explain how ETWB feeding affects hepatic metabolism, but factors (i.e., xenometabolites) associated with specific microbes may be involved. OBJECTIVE: The objective of this study was to characterize ETWB-driven shifts in the cecal microbiome and to identify correlates between microbial changes and diet-related differences in liver metabolism in diet-induced obese mice that typically display steatosis...
October 19, 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27795741/hepatic-transcriptome-implications-for-palm-fruit-juice-deterrence-of-type-2-diabetes-mellitus-in-young-male-nile-rats
#17
Soon-Sen Leow, Julia Bolsinger, Andrzej Pronczuk, K C Hayes, Ravigadevi Sambanthamurthi
BACKGROUND: The Nile rat (NR, Arvicanthis niloticus) is a model of carbohydrate-induced type 2 diabetes mellitus (T2DM) and the metabolic syndrome. A previous study found that palm fruit juice (PFJ) delayed or prevented diabetes and in some cases even reversed its early stages in young NRs. However, the molecular mechanisms by which PFJ exerts these anti-diabetic effects are unknown. In this study, the transcriptomic effects of PFJ were studied in young male NRs, using microarray gene expression analysis...
2016: Genes & Nutrition
https://www.readbyqxmd.com/read/27778020/developmental-programming-of-the-metabolic-syndrome-next-generation-sequencing-analysis-of-transcriptome-expression-in-a-rat-model-of-maternal-high-fructose-intake
#18
Yung-Mei Chao, You-Lin Tain, Steve Leu, Kay L H Wu, Wei-Chia Lee, Julie Y H Chan
Excessive fructose intake is related to a high prevalence of metabolic syndrome, while little attention has been paid to the impact of maternal high-fructose (HF) intake on the development of metabolic syndrome and organ-specific transcriptome alterations in the offspring. We utilized RNA next-generation sequencing (NGS) technology to analyze the transcriptome expression in four organs (kidney, brain, heart, and urinary bladder) from 1-day, 3-week, and 3-month-old male offspring exposed to maternal HF diet...
October 25, 2016: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/27777632/the-effect-of-maternal-undernutrition-on-the-rat-placental-transcriptome-protein-restriction-up-regulates-cholesterol-transport
#19
Zoe Daniel, Angelina Swali, Richard Emes, Simon C Langley-Evans
BACKGROUND: Fetal exposure to a maternal low protein diet during rat pregnancy is associated with hypertension, renal dysfunction and metabolic disturbance in adult life. These effects are present when dietary manipulations target only the first half of pregnancy. It was hypothesised that early gestation protein restriction would impact upon placental gene expression and that this may give clues to the mechanism which links maternal diet to later consequences. METHODS: Pregnant rats were fed control or a low protein diet from conception to day 13 gestation...
2016: Genes & Nutrition
https://www.readbyqxmd.com/read/27768772/de-novo-transcriptomes-of-forsythia-koreana-using-a-novel-assembly-method-insight-into-tissue-and-species-specific-expression-of-lignan-biosynthesis-related-gene
#20
Akira Shiraishi, Jun Murata, Erika Matsumoto, Shin Matsubara, Eiichiro Ono, Honoo Satake
Forsythia spp. are perennial woody plants which are one of the most extensively used medicinal sources of Chinese medicines and functional diets owing to their lignan contents. Lignans have received widespread attention as leading compounds in the development of antitumor drugs and healthy diets for reducing the risks of lifestyle-related diseases. However, the molecular basis of Forsythia has yet to be established. In this study, we have verified de novo deep transcriptome of Forsythia koreana leaf and callus using the Illumina HiSeq 1500 platform...
2016: PloS One
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