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Diet transcriptome

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https://www.readbyqxmd.com/read/29341863/distinct-gene-signatures-predict-insulin-resistance-in-young-mice-with-high-fat-diet-induced-obesity
#1
Katherine Chen, Alice Jih, Olivia Osborn, Sarah T Kavaler, Wenxian Fu, Roman Sasik, Rintaro Saito, Jane J Kim
Highly inbred C57BL/6 mice show wide variation in their degree of insulin resistance in response to diet-induced obesity even though they are almost genetically identical. Here we employed transcriptional profiling by RNA sequencing (RNA-Seq) of visceral adipose tissue (VAT) and liver in young mice to determine how gene expression patterns correlate with the later development of high-fat diet (HFD)-induced insulin resistance in adulthood. To accomplish this goal, we partially removed and banked tissues from pubertal mice...
January 8, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29330509/transcriptome-analysis-reveals-carbohydrate-mediated-liver-immune-responses-in-epinephelus-akaara
#2
Yunxia Yang, Tao Han, Jia Xiao, Xinyu Li, Jiteng Wang
As the cheapest energy source, carbohydrates are used in fish feeds to improve physical quality and reduce catabolism of proteins and lipids. The liver is the primary organ for metabolism and is also an important site of immune regulation. Here, we investigated the effect of different dietary carbohydrate levels on growth and health by evaluating the liver transcriptome of Epinephelus akaara. In this study, E. akaara juveniles were fed diets containing few (0% corn starch), moderate (18% corn starch), and high (30% corn starch) levels of dietary carbohydrate...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329327/selection-of-housekeeping-genes-and-demonstration-of-rnai-in-cotton-leafhopper-amrasca-biguttula-biguttula-ishida
#3
Satnam Singh, Mridula Gupta, Suneet Pandher, Gurmeet Kaur, Pankaj Rathore, Subba Reddy Palli
Amrasca biguttula biguttula (Ishida) commonly known as cotton leafhopper is a severe pest of cotton and okra. Not much is known on this insect at molecular level due to lack of genomic and transcriptomic data. To prepare for functional genomic studies in this insect, we evaluated 15 common housekeeping genes (Tub, B-Tub, EF alpha, GADPH, UbiCF, RP13, Ubiq, G3PD, VATPase, Actin, 18s, 28s, TATA, ETF, SOD and Cytolytic actin) during different developmental stages and under starvation stress. We selected early (1st and 2nd), late (3rd and 4th) stage nymphs and adults for identification of stable housekeeping genes using geNorm, NormFinder, BestKeeper and RefFinder software...
2018: PloS One
https://www.readbyqxmd.com/read/29328911/western-diet-triggers-nlrp3-dependent-innate-immune-reprogramming
#4
Anette Christ, Patrick Günther, Mario A R Lauterbach, Peter Duewell, Debjani Biswas, Karin Pelka, Claus J Scholz, Marije Oosting, Kristian Haendler, Kevin Baßler, Kathrin Klee, Jonas Schulte-Schrepping, Thomas Ulas, Simone J C F M Moorlag, Vinod Kumar, Min Hi Park, Leo A B Joosten, Laszlo A Groh, Niels P Riksen, Terje Espevik, Andreas Schlitzer, Yang Li, Michael L Fitzgerald, Mihai G Netea, Joachim L Schultze, Eicke Latz
Long-term epigenetic reprogramming of innate immune cells in response to microbes, also termed "trained immunity," causes prolonged altered cellular functionality to protect from secondary infections. Here, we investigated whether sterile triggers of inflammation induce trained immunity and thereby influence innate immune responses. Western diet (WD) feeding of Ldlr-/- mice induced systemic inflammation, which was undetectable in serum soon after mice were shifted back to a chow diet (CD). In contrast, myeloid cell responses toward innate stimuli remained broadly augmented...
January 11, 2018: Cell
https://www.readbyqxmd.com/read/29325454/down-expression-of-p2rx2-kcnq5-erbb3-and-socs3-through-dna-hypermethylation-in-elderly-women-with-presbycusis
#5
Amal Bouzid, Ibtihel Smeti, Leila Dhouib, Magali Roche, Imen Achour, Aida Khalfallah, Abdullah Ahmed Gibriel, Ilhem Charfeddine, Hammadi Ayadi, Joel Lachuer, Abdelmonem Ghorbel, Christine Petit, Saber Masmoudi
CONTEXT: Presbycusis, an age-related hearing impairment (ARHI), represents the most common sensory disability in adults. Today, the molecular mechanisms underlying presbycusis remain unclear. This is in particular due to the fact that ARHI is a multifactorial complex disorder resulting from several genomic factors interacting with lifelong cumulative effects of: disease, diet, and environment. OBJECTIVE: Identification of novel biomarkers for presbycusis. MATERIALS AND METHODS: We selectively ascertained eighteen elderly unrelated women lacking environmental and metabolic risk factors...
January 11, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29315239/mangiferin-accelerates-glycolysis-and-enhances-mitochondrial-bioenergetics
#6
Zhongbo Liu, Pasha Apontes, Ekaterina V Fomenko, Nan Chi, Victor L Schuster, Irwin J Kurland, Jeffrey E Pessin, Yuling Chi
One of the main causes of hyperglycemia is inefficient or impaired glucose utilization by skeletal muscle, which can be exacerbated by chronic high caloric intake. Previously, we identified a natural compound, mangiferin (MGF) that improved glucose utilization in high fat diet (HFD)-induced insulin resistant mice. To further identify the molecular mechanisms of MGF action on glucose metabolism, we conducted targeted metabolomics and transcriptomics studies of glycolyic and mitochondrial bioenergetics pathways in skeletal muscle...
January 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29276754/uncovering-a-predictive-molecular-signature-for-the-onset-of-nash-related-fibrosis-in-a-translational-nash-mouse-model
#7
Arianne van Koppen, Lars Verschuren, Anita M van den Hoek, Joanne Verheij, Martine C Morrison, Kelvin Li, Hiroshi Nagabukuro, Adalberto Costessi, Martien P M Caspers, Tim J van den Broek, John Sagartz, Cornelis Kluft, Carine Beysen, Claire Emson, Alain J van Gool, Roel Goldschmeding, Reinout Stoop, Ivana Bobeldijk-Pastorova, Scott M Turner, Guido Hanauer, Roeland Hanemaaijer
Background & Aims: The incidence of nonalcoholic steatohepatitis (NASH) is increasing. The pathophysiological mechanisms of NASH and the sequence of events leading to hepatic fibrosis are incompletely understood. The aim of this study was to gain insight into the dynamics of key molecular processes involved in NASH and to rank early markers for hepatic fibrosis. Methods: A time-course study in low-density lipoprotein-receptor knockout. Leiden mice on a high-fat diet was performed to identify the temporal dynamics of key processes contributing to NASH and fibrosis...
2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29258446/transcriptome-analysis-of-ruminal-epithelia-revealed-potential-regulatory-mechanisms-involved-in-host-adaptation-to-gradual-high-fermentable-dietary-transition-in-beef-cattle
#8
K Zhao, Y H Chen, G B Penner, M Oba, L L Guan
BACKGROUND: The transition from a high forage to a highly fermentable diet can induce digestive disorders in the rumen. To date, the host mechanisms that regulate the adaption to such dietary transition are largely unknown. To understand the molecular mechanisms involved in such phenomena, RNA-sequencing was performed to identify the changes in the transcriptome of ruminal epithelia during gradual transition from a diet containing 0% to 89% grain. RESULTS: In total, the expression of 11,044, 11,322 and 11,282 genes were detected in ruminal epithelia of beef heifers (n = 15) fed 0%, 72% and 89% barley grain diet, respectively...
December 19, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29246445/protective-effect-of-genetic-deletion-of-pannexin1-in-experimental-mouse-models-of-acute-and-chronic-liver-disease
#9
Joost Willebrords, Michaël Maes, Isabel Veloso Alves Pereira, Tereza Cristina da Silva, Veronica Mollica Govoni, Valéria Veras Lopes, Sara Crespo Yanguas, Valery I Shestopalov, Marina Sayuri Nogueira, Inar Alves de Castro, Anwar Farhood, Inge Mannaerts, Leo van Grunsven, Jephte Akakpo, Margitta Lebofsky, Hartmut Jaeschke, Bruno Cogliati, Mathieu Vinken
Pannexins are transmembrane proteins that form communication channels connecting the cytosol of an individual cell with its extracellular environment. A number of studies have documented the presence of pannexin1 in liver as well as its involvement in inflammatory responses. In this study, it was investigated whether pannexin1 plays a role in acute liver failure and non-alcoholic steatohepatitis, being prototypical acute and chronic liver pathologies, respectively, both featured by liver damage, oxidative stress and inflammation...
December 12, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29241556/hepatic-dysfunction-caused-by-consumption-of-a-high-fat-diet
#10
Anthony R Soltis, Norman J Kennedy, Xiaofeng Xin, Feng Zhou, Scott B Ficarro, Yoon Sing Yap, Bryan J Matthews, Douglas A Lauffenburger, Forest M White, Jarrod A Marto, Roger J Davis, Ernest Fraenkel
Obesity is a major human health crisis that promotes insulin resistance and, ultimately, type 2 diabetes. The molecular mechanisms that mediate this response occur across many highly complex biological regulatory levels that are incompletely understood. Here, we present a comprehensive molecular systems biology study of hepatic responses to high-fat feeding in mice. We interrogated diet-induced epigenomic, transcriptomic, proteomic, and metabolomic alterations using high-throughput omic methods and used a network modeling approach to integrate these diverse molecular signals...
December 12, 2017: Cell Reports
https://www.readbyqxmd.com/read/29240779/impact-of-maternal-high-fat-diet-on-hypothalamic-transcriptome-in-neonatal-sprague-dawley-rats
#11
Sanna Barrand, Tamsyn M Crowley, Ryan J Wood-Bradley, Kirstie A De Jong, James A Armitage
Maternal consumption of a high fat diet during early development has been shown to impact the formation of hypothalamic neurocircuitry, thereby contributing to imbalances in appetite and energy homeostasis and increasing the risk of obesity in subsequent generations. Early in postnatal life, the neuronal projections responsible for energy homeostasis develop in response to appetite-related peptides such as leptin. To date, no study characterises the genome-wide transcriptional changes that occur in response to exposure to high fat diet during this critical window...
2017: PloS One
https://www.readbyqxmd.com/read/29228654/lack-of-chemopreventive-effects-of-p2x7r-inhibitors-against-pancreatic-cancer
#12
Altaf Mohammed, Naveena B Janakiram, Venkateshwar Madka, Gopal Pathuri, Qian Li, Rebekah Ritchie, Laura Biddick, Hannah Kutche, Yuting Zhang, Anil Singh, Hariprasad Gali, Stan Lightfoot, Vernon E Steele, Chen S Suen, Chinthalapally V Rao
Pancreatic cancer (PC) is an almost uniformly lethal disease with inflammation playing an important role in its progression. Sustained stimulation of purinergic receptor P2X7 drives induction of NLRP inflammasome activation. To understand the role of P2X7 receptor and inflammasome, we performed transcriptomic analysis of p48Cre/+-LSL-KrasG12D/+ mice pancreatic tumors by next generation sequencing. Results showed that P2X7R's key inflammasome components, IL-1β and caspase-1 are highly expressed (p < 0.05) in pancreatic tumors...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29227579/obesity-type-2-diabetes-increases-inflammation-periosteal-reactive-bone-formation-and-osteolysis-during-staphylococcus-aureus-implant-associated-bone-infection
#13
Christopher W Farnsworth, Eric M Schott, Abigail M Benvie, Jacob Zukoski, Stephen L Kates, Edward M Schwarz, Steven R Gill, Michael J Zuscik, Robert A Mooney
Obese and type 2 diabetic (T2D) patients have a 5-fold increased rate of infection following placement of an indwelling orthopaedic device. Though implant infections are associated with inflammation, periosteal reactive bone formation and osteolysis, the effect of obesity/T2D on these complicating factors has not been studied. To address this question, C57BL/6J mice were fed a high fat diet (60% Kcal from fat) to induce obesity/T2D, or a control diet (10% Kcal from fat) for three months, and challenged with a transtibial pin coated with a bioluminescent USA300 strain of S...
December 11, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29222421/the-transcriptomic-signature-of-disease-development-and-progression-of-nonalcoholic-fatty-liver-disease
#14
Sophie Cazanave, Alexei Podtelezhnikov, Kristian Jensen, Mulugeta Seneshaw, Divya P Kumar, Hae-Ki Min, Prasanna K Santhekadur, Bubu Banini, Adolfo Gabriele Mauro, Abdul M Oseini, Robert Vincent, Keith Q Tanis, Andrea L Webber, Liangsu Wang, Pierre Bedossa, Faridoddin Mirshahi, Arun J Sanyal
A longitudinal molecular model of the development and progression of nonalcoholic fatty liver disease (NAFLD) over time is lacking. We have recently validated a high fat/sugar water-induced animal (an isogenic strain of C57BL/6 J:129S1/SvImJ mice) model of NAFLD that closely mimics most aspects of human disease. The hepatic transcriptome of such mice with fatty liver (8 weeks), steatohepatitis with early fibrosis (16-24 weeks) and advanced fibrosis (52 weeks) after initiation of the diet was evaluated and compared to mice on chow diet...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222026/transcriptome-analysis-provides-insights-into-the-immune-responsive-pathways-and-genes-in-the-head-kidney-of-tiger-grouper-epinephelus-fuscoguttatus-fed-with-spatholobus-suberectus-phellodendron-amurense-or-eclipta-prostrata
#15
Yan Cai, Shifeng Wang, Weiliang Guo, Zhenyu Xie, Yu Zheng, Zhenjie Cao, Yongcan Zhou
The tiger grouper, Epinephelus fuscoguttatus, is an economically important fish in Southeast Asia but has been plagued by several diseases. Spatholobus suberectus (S), Phellodendron amurense (P), and Eclipta prostrate (E) are three commonly used Chinese medicinal herbs. Although previous pharmacological and clinical studies indicated that S, P, and E possess a variety of beneficial functions in mammals, little is known about their functions in farmed fish and the underlying molecular mechanism of their actions...
December 6, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29218900/single-subject-transcriptome-analysis-to-identify-functionally-signed-gene-set-or-pathway-activity
#16
Joanne Berghout, Qike Li, Nima Pouladi, Jianrong Li, Yves A Lussier
Analysis of single-subject transcriptome response data is an unmet need of precision medicine, made challenging by the high dimension, dynamic nature and difficulty in extracting meaningful signals from biological or stochastic noise. We have proposed a method for single subject analysis that uses a mixture model for transcript fold-change clustering from isogenically paired samples, followed by integration of these distributions with Gene Ontology Biological Processes (GO-BP) to reduce dimension and identify functional attributes...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29197252/oregano-dietary-supplementation-modifies-the-liver-transcriptome-profile-in-broilers-rnaseq-analysis
#17
Marcella Sabino, Stefano Capomaccio, Katia Cappelli, Andrea Verini-Supplizi, Lorenzo Bomba, Paolo Ajmone-Marsan, Gabriella Cobellis, Oliviero Olivieri, Camillo Pieramati, Massimo Trabalza-Marinucci
Intensive farming of broilers involves stressful conditions that reduce animal welfare and performance. New dietary strategies to improve performance and meat quality include the administration of plant extracts. Oregano (Origanum vulgare L.) is known for its antimicrobial, anti-fungal, insecticidal and antioxidant properties. However, studies on diet supplementation with oregano are mainly focused on the evaluation of animal performance, while partial information is available on transcriptomics and nutrigenomics and, in particular, Next Generation Sequencing (NGS) is not widely applied...
November 21, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29194424/functional-foods-and-lifestyle-approaches-for-diabetes-prevention-and-management
#18
REVIEW
Ahmad Alkhatib, Catherine Tsang, Ali Tiss, Theeshan Bahorun, Hossein Arefanian, Roula Barake, Abdelkrim Khadir, Jaakko Tuomilehto
Functional foods contain biologically active ingredients associated with physiological health benefits for preventing and managing chronic diseases, such as type 2 diabetes mellitus (T2DM). A regular consumption of functional foods may be associated with enhanced anti-oxidant, anti-inflammatory, insulin sensitivity, and anti-cholesterol functions, which are considered integral to prevent and manage T2DM. Components of the Mediterranean diet (MD)-such as fruits, vegetables, oily fish, olive oil, and tree nuts-serve as a model for functional foods based on their natural contents of nutraceuticals, including polyphenols, terpenoids, flavonoids, alkaloids, sterols, pigments, and unsaturated fatty acids...
December 1, 2017: Nutrients
https://www.readbyqxmd.com/read/29177809/parallel-in-vivo-and-in-vitro-transcriptomics-analysis-reveals-calcium-and-zinc-signalling-in-the-brain-as-sensitive-targets-of-hbcd-neurotoxicity
#19
V Reffatto, J D Rasinger, T S Carroll, T Ganay, A-K Lundebye, I Sekler, M Hershfinkel, C Hogstrand
Hexabromocyclododecane (HBCD) is a brominated flame retardant (BFR) that accumulates in humans and affects the nervous system. To elucidate the mechanisms of HBCD neurotoxicity, we used transcriptomic profiling in brains of female mice exposed through their diet to HBCD (199 mg/kg body weight per day) for 28 days and compared with those of neuronal N2A and NSC-19 cell lines exposed to 1 or 2 µM HBCD. Similar pathways and functions were affected both in vivo and in vitro, including Ca2+ and Zn2+ signalling, glutamatergic neuron activity, apoptosis, and oxidative stress...
November 25, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29174952/interactions-between-diet-and-the-intestinal-microbiota-alter-intestinal-permeability-and-colitis-severity-in-mice
#20
Sean R Llewellyn, Graham J Britton, Eduardo J Contijoch, Olivia H Vennaro, Arthur Mortha, Jean-Frederic Colombel, Ari Grinspan, Jose C Clemente, Miriam Merad, Jeremiah J Faith
BACKGROUND & AIMS: It is not clear how the complex interactions between diet and the intestinal microbiota affect development of mucosal inflammation or inflammatory bowel disease. We investigated interactions between dietary ingredients, nutrients, and the microbiota in specific pathogen-free (SPF) and germ-free (GF) mice given more than 40 unique diets; we quantified individual and synergistic effects of dietary macronutrients and the microbiota on intestinal health and development of colitis...
November 23, 2017: Gastroenterology
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