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Diet transcriptome

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https://www.readbyqxmd.com/read/28927467/associations-among-dietary-non-fiber-carbohydrate-ruminal-microbiota-and-epithelium-g-protein-coupled-receptor-and-histone-deacetylase-regulations-in-goats
#1
Hong Shen, Zhongyan Lu, Zhihui Xu, Zhan Chen, Zanming Shen
BACKGROUND: Diet-derived short-chain fatty acids (SCFAs) in the rumen have broad effects on the health and growth of ruminants. The microbe-G-protein-coupled receptor (GPR) and microbe-histone deacetylase (HDAC) axes might be the major pathway mediating these effects. Here, an integrated approach of transcriptome sequencing and 16S rRNA gene sequencing was applied to investigate the synergetic responses of rumen epithelium and rumen microbiota to the increased intake of dietary non-fiber carbohydrate (NFC) from 15 to 30% in the goat model...
September 19, 2017: Microbiome
https://www.readbyqxmd.com/read/28924246/rna-seq-analysis-of-the-kidneys-of-broiler-chickens-fed-diets-containing-different-concentrations-of-calcium
#2
Woncheoul Park, Deivendran Rengaraj, Dong-Yong Kil, Heebal Kim, Hak-Kyo Lee, Ki-Duk Song
Calcium (Ca) is required for normal growth and is involved in cellular physiology, signal transduction, and bone mineralization. In humans, inadequate Ca intake causes hypocalcaemia, and excessive Ca intake causes hypercalcemia. In chicken, Ca is also required for body weight gain and eggshell formation. However, transcriptomic responses to low/high Ca intake, and mechanisms affecting body weight have not been explored. In this study, we performed comparative RNA sequencing (RNA-seq) using the kidney of broiler chickens fed diets containing 0...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28904640/short-term-dietary-methionine-supplementation-affects-one-carbon-metabolism-and-dna-methylation-in-the-mouse-gut-and-leads-to-altered-microbiome-profiles-barrier-function-gene-expression-and-histomorphology
#3
Isabelle R Miousse, Rupak Pathak, Sarita Garg, Charles M Skinner, Stepan Melnyk, Oleksandra Pavliv, Howard Hendrickson, Reid D Landes, Annie Lumen, Alan J Tackett, Nicolaas E P Deutz, Martin Hauer-Jensen, Igor Koturbash
BACKGROUND: Methionine, a central molecule in one-carbon metabolism, is an essential amino acid required for normal growth and development. Despite its importance to biological systems, methionine is toxic when administered at supra-physiological levels. The aim of this study was to investigate the effects of short-term methionine dietary modulation on the proximal jejunum, the section of the gut specifically responsible for amino acid absorption, in a mouse model. Eight-week-old CBA/J male mice were fed methionine-adequate (MAD; 6...
2017: Genes & Nutrition
https://www.readbyqxmd.com/read/28903954/quantity-and-source-of-dietary-protein-influence-metabolite-production-by-gut-microbiota-and-rectal-mucosa-gene-expression-a-randomized-parallel-double-blind-trial-in-overweight-humans
#4
Martin Beaumont, Kevin Joseph Portune, Nils Steuer, Annaïg Lan, Victor Cerrudo, Marc Audebert, Florent Dumont, Giulia Mancano, Nadezda Khodorova, Mireille Andriamihaja, Gheorghe Airinei, Daniel Tomé, Robert Benamouzig, Anne-Marie Davila, Sandrine Paule Claus, Yolanda Sanz, François Blachier
Background: Although high-protein diets (HPDs) are frequently consumed for body-weight control, little is known about the consequences for gut microbiota composition and metabolic activity and for large intestine mucosal homeostasis. Moreover, the effects of HPDs according to the source of protein need to be considered in this context.Objective: The objective of this study was to evaluate the effects of the quantity and source of dietary protein on microbiota composition, bacterial metabolite production, and consequences for the large intestinal mucosa in humans...
September 13, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28894112/perinatal-malnutrition-leads-to-sexually-dimorphic-behavioral-responses-with-associated-epigenetic-changes-in-the-mouse-brain
#5
Daniel Nätt, Riccardo Barchiesi, Josef Murad, Jian Feng, Eric J Nestler, Frances A Champagne, Annika Thorsell
Childhood malnutrition is a risk factor for mental disorders, such as major depression and anxiety. Evidence shows that similar early life adversities induce sex-dependent epigenetic reprogramming. However, little is known about how genes are specifically affected by early malnutrition and the implications for males and females respectively. One relevant target is neuropeptide Y (NPY), which regulates both stress and food-intake. We studied maternal low protein diet (LPD) during pregnancy/lactation in mice...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28892663/hepatic-transcriptome-analysis-of-juvenile-gift-tilapia-oreochromis-niloticus-fed-diets-supplemented-with-different-concentrations-of-resveratrol
#6
Yao Zheng, Wei Wu, Gengdong Hu, Zhixiang Zhao, Shunlong Meng, Limin Fan, Chao Song, Liping Qiu, Jiazhang Chen
The GIFT (Genetically Improved Farmed Tilapia) tilapia, Oreochromis niloticus, is cultured widely for the production of freshwater fish in China. Streptococcosis, which is related to pathogenic infections, occurs frequently in juvenile and adult female GIFT individuals. Resveratrol (RES) has been used in feed to control these infections in freshwater tilapia. To address the effects of RES on tilapia, we used high-throughput RNA sequencing technology (RNA-Seq, HiSeq. 2500) to explore the global transcriptomic response and specific involvement of hepatic mRNA of juvenile O...
September 8, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28886690/transcriptome-profiling-of-antiviral-immune-and-dietary-fatty-acid-dependent-responses-of-atlantic-salmon-macrophage-like-cells
#7
Khalil Eslamloo, Xi Xue, Jennifer R Hall, Nicole C Smith, Albert Caballero-Solares, Christopher C Parrish, Richard G Taylor, Matthew L Rise
BACKGROUND: Due to the limited availability and high cost of fish oil in the face of increasing aquaculture production, there is a need to reduce usage of fish oil in aquafeeds without compromising farm fish health. Therefore, the present study was conducted to determine if different levels of vegetable and fish oils can alter antiviral responses of salmon macrophage-like cells (MLCs). Atlantic salmon (Salmo salar) were fed diets containing 7.4% (FO7) or 5.1% (FO5) fish oil. These diets were designed to be relatively low in EPA + DHA (i...
September 8, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28879580/plant-and-animal-micrornas-mirnas-and-their-potential-for-inter-kingdom-communication
#8
REVIEW
Yuhai Zhao, Lin Cong, Walter J Lukiw
microRNAs (miRNAs) comprise a class of ~18-25 nucleotide (nt) single-stranded non-coding RNAs (sncRNAs) that are the smallest known carriers of gene-encoded, post-transcriptional regulatory information in both plants and animals. There are many fundamental similarities between plant and animal miRNAs-the miRNAs of both kingdoms play essential roles in development, aging and disease, and the shaping of the transcriptome of many cell types. Both plant and animal miRNAs appear to predominantly exert their genetic and transcriptomic influences by regulating gene expression at the level of messenger RNA (mRNA) stability and/or translational inhibition...
September 6, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28875582/identification-of-signaling-pathways-targeted-by-the-food-contaminant-fb1-transcriptome-and-kinome-analysis-of-samples-from-pig-liver-and-intestine
#9
Marion Régnier, Pascal Gourbeyre, Philippe Pinton, Scott Napper, Joëlle Laffite, Anne-Marie Cossalter, Jean-Denis Bailly, Yannick Lippi, Justine Bertrand-Michel, Ana Paula F R L Bracarense, Hervé Guillou, Nicolas Loiseau, Isabelle P Oswald
SCOPE: Fumonisin B1 (FB1) is a mycotoxin produced by Fusarium species. In mammals, this toxin causes widespread organ-specific damage; it promotes hepatotoxicity, is immunotoxic, alters intestinal functions… Despite its inhibitory effect on de novo ceramide synthesis, its molecular mechanism of action and toxicity are not totally elucidated. METHOD & RESULTS: To explore the mechanism of FB1 toxicity, we analyzed the transcriptome and kinome of two organs targeted by FB1: the liver and the jejunum...
September 5, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28866860/protective-effects-of-dietary-garlic-powder-against-cadmium-induced-toxicity-in-sea-bass-liver-a-chemical-biochemical-and-transcriptomic-approach
#10
Amin Mosbah, Hamadi Guerbej, Hamadi Boussetta, Zied Bouraoui, Mohamed Banni
To investigate the protective effect of garlic powder on cadmium-induced toxicity sea bass liver, juvenile fishes where maintained under three food diets (diet 1: normal without garlic supply, diet 2: 2% garlic powder; diet 3: 6% garlic powder). After 30 days of specific diets, each group was injected with 500 μg kg(-1)of Cd. The control group was the one fed with normal diet and not injected with Cd. Liver Cd, Zn, and Se loads was assessed after 1 and 3 days of Cd injections. Moreover, antioxidant enzymes activities termed as catalase, superoxide dismutase, and glutathione peroxydase as well as their gene expression levels were monitored...
September 2, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28865488/distinct-transcriptional-and-metabolic-profiles-associated-with-empathy-in-buddhist-priests-a-pilot-study
#11
Junji Ohnishi, Satoshi Ayuzawa, Seiji Nakamura, Shigeko Sakamoto, Miyo Hori, Tomoko Sasaoka, Eriko Takimoto-Ohnishi, Masakazu Tanatsugu, Kazuo Murakami
BACKGROUND: Growing evidence suggests that spiritual/religious involvement may have beneficial effects on both psychological and physical functions. However, the biological basis for this relationship remains unclear. This study explored the role of spiritual/religious involvement across a wide range of biological markers, including transcripts and metabolites, associated with the psychological aspects of empathy in Buddhist priests. METHODS: Ten professional Buddhist priests and 10 age-matched non-priest controls were recruited...
September 2, 2017: Human Genomics
https://www.readbyqxmd.com/read/28852200/early-gestational-maternal-low-protein-diet-diminishes-hepatic-response-to-fasting-in-young-adult-male-mice
#12
Noriko Sato, Katsuko Sudo, Masayo Mori, Chihiro Imai, Masaaki Muramatsu, Masahiro Sugimoto
Maternal low-protein (MLP) diet can lead to hepatic steatosis, which only develops with ageing. It is still unclear whether the young offspring show any signs of past exposure to prenatal adverse conditions. We hypothesized that early nutritional insult would first affect the dynamic responsiveness to nutritional challenges rather than the static state. We analyzed the transcriptome and metabolome profiles of the hepatic response to fasting/refeeding in young male mice offspring to identify changes induced by early gestational MLP diet...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28845460/integration-of-metabolomics-and-transcriptomics-reveals-a-complex-diet-of-mycobacterium-tuberculosis-during-early-macrophage-infection
#13
Michael Zimmermann, Maria Kogadeeva, Martin Gengenbacher, Gayle McEwen, Hans-Joachim Mollenkopf, Nicola Zamboni, Stefan Hugo Ernst Kaufmann, Uwe Sauer
Nutrient acquisition from the host environment is crucial for the survival of intracellular pathogens, but conceptual and technical challenges limit our knowledge of pathogen diets. To overcome some of these technical roadblocks, we exploited an experimentally accessible model for early infection of human macrophages by Mycobacterium tuberculosis, the etiological agent of tuberculosis, to study host-pathogen interactions with a multi-omics approach. We collected metabolomics and complete transcriptome RNA sequencing (dual RNA-seq) data of the infected macrophages, integrated them in a genome-wide reaction pair network, and identified metabolic subnetworks in host cells and M...
July 2017: MSystems
https://www.readbyqxmd.com/read/28842339/gangjihwan-a-polyherbal-composition-inhibits-fat-accumulation-through-the-modulation-of-lipogenic-transcription-factors-srebp1c-ppar%C3%AE-and-c-ebp%C3%AE
#14
Jaewoong Jang, Yoonju Jung, Seyeon Chae, Soo Hyun Cho, Michung Yoon, Heejung Yang, Soon Shik Shin, Yoosik Yoon
ETHNOPHARMACOLOGICAL RELEVANCE: Gangjihwan (DF) which is composed of Ephedra intermedia, Lithospermum erythrorhizon, and Rheum palmatum has been used for the treatment of obesity in traditional medical clinics in Korea. AIM OF THE STUDY: This study was conducted to standardize DF and elucidate its mechanism of action for inhibiting fat accumulation in adipocytes and adipose tissues. MATERIALS AND METHODS: The herbal ingredients of DF were extracted in water, 30% ethanol or 70% ethanol and freeze-dried followed by HPLC analyses...
August 24, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28832647/transcriptional-responses-of-ecologically-diverse-drosophila-species-to-larval-diets-differing-in-relative-sugar-and-protein-ratios
#15
Nestor O Nazario-Yepiz, Mariana Ramirez Loustalot-Laclette, Javier Carpinteyro-Ponce, Cei Abreu-Goodger, Therese Ann Markow
We utilized three ecologically diverse Drosophila species to explore the influence of ecological adaptation on transcriptomic responses to isocaloric diets differing in their relative proportions of protein to sugar. Drosophila melanogaster, a cosmopolitan species that breeds in decaying fruit, exemplifies individuals long exposed to a Western diet higher in sugar, while the natural diet of the cactophilic D. mojavensis, is much lower in carbohydrates. Drosophila arizonae, the sister species of D. mojavensis, is largely cactophilic, but also utilizes rotting fruits that are higher in sugars than cacti...
2017: PloS One
https://www.readbyqxmd.com/read/28830340/relating-past-and-present-diet-to-phenotypic-and-transcriptomic-variation-in-the-fruit-fly
#16
Christina M May, Bas J Zwaan
BACKGROUND: Sub-optimal developmental diets often have adverse effects on long-term fitness and health. One hypothesis is that such effects are caused by mismatches between the developmental and adult environment, and may be mediated by persistent changes in gene expression. However, there are few experimental tests of this hypothesis. Here we address this using the fruit fly, Drosophila melanogaster. We vary diet during development and adulthood in a fully factorial design and assess the consequences for both adult life history traits and gene expression at middle and old age...
August 22, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28822867/de-novo-assembly-and-characterization-of-seabass-lateolabrax-japonicus-transcriptome-and-expression-of-hepatic-genes-following-different-dietary-phosphorus-calcium-levels
#17
Kang-Le Lu, Zhong-Li Ji, Samad Rahimnejad, Chun-Xiao Zhang, Ling Wang, Kai Song
Fish farming seriously influences the aquatic environment because most dietary phosphorus (P) is excreted in the effluent. To increase the P utilization in fish, molecular techniques should be explored given the remarkable development of these techniques. Thus, to identify the candidate genes related to P utilization and molecular alterations following administration of a P-deficient diet in seabass Lateolabrax japonicus, we assessed the de novo pituitary, gill, intestine, liver, kidney, scales and vertebra transcriptomes, and we compared the expression of hepatic genes with three diets varying in P and Ca levels: diet I (0...
August 9, 2017: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/28821567/chronic-spinal-cord-changes-in-a-high-fat-diet-fed-male-rat-model-of-thoracic-spinal-contusion
#18
Redin A Spann, William J Lawson, Raymond J Grill, Michael R Garrett, Bernadette E Grayson
Individuals that suffer injury to the spinal cord can result in long-term, debilitating sequelae. Spinal cord injured patients have increased risk for the development of metabolic disease which can further hinder the effectiveness of treatments to rehabilitate the cord and improve quality of life. In the present study, we sought to understand the impact of high-fat diet induced obesity on spinal cord injury (SCI) by examining transcriptome changes in the area of the injury and rostral and caudal to site of damage 12 weeks after injury...
August 18, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/28814277/phenotypes-antioxidant-responses-and-gene-expression-changes-accompanying-a-sugar-only-diet-in-bactrocera-dorsalis-hendel-diptera-tephritidae
#19
Er-Hu Chen, Qiu-Li Hou, Dan-Dan Wei, Hong-Bo Jiang, Jin-Jun Wang
BACKGROUND: Diet composition (yeast:carbohydrate ratio) is an important determinant of growth, development, and reproduction. Recent studies have shown that decreased yeast intake elicits numerous transcriptomic changes and enhances somatic maintenance and lifespan, which in turn reduces reproduction in various insects. However, our understanding of the responses leading to a decrease in yeast ratio to 0% is limited. RESULTS: In the present study, we investigated the effects of a sugar-only diet (SD) on the gene expression patterns of the oriental fruit fly, Bactrocera dorsalis (Hendel), one of the most economically important pests in the family Tephritidae...
August 17, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28811572/inhibition-of-connexin-hemichannels-alleviates-non-alcoholic-steatohepatitis-in-mice
#20
Joost Willebrords, Bruno Cogliati, Isabel Veloso Alves Pereira, Tereza Cristina da Silva, Sara Crespo Yanguas, Michaël Maes, Veronica Mollica Govoni, Andressa Lima, Daniele Aparecida Felisbino, Elke Decrock, Marina Sayuri Nogueira, Inar Alves de Castro, Isabelle Leclercq, Luc Leybaert, Robim Marcelino Rodrigues, Mathieu Vinken
While gap junctions mediate intercellular communication and support liver homeostasis, connexin hemichannels are preferentially opened by pathological stimuli, including inflammation and oxidative stress. The latter are essential features of non-alcoholic steatohepatitis. In this study, it was investigated whether connexin32 and connexin43 hemichannels play a role in non-alcoholic steatohepatitis. Mice were fed a choline-deficient high-fat diet or normal diet for 8 weeks. Thereafter, TAT-Gap24 or TAT-Gap19, specific inhibitors of hemichannels composed of connexin32 and connexin43, respectively, were administered for 2 weeks...
August 15, 2017: Scientific Reports
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