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breast,soft tissue sarcoma,skin cancer

Chenthuran Deivaraju, H Thomas Temple, Norman Block, Philip Robinson, Andrew V Schally
AIM: Luteinizing hormone releasing hormone (LHRH) is a neurohormone, secreted by the hypothalamus, which regulates the secretion of gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the pituitary. LHRH acts by binding to receptors located in the pituitary gland. These receptors (LHRH receptors) have also been found in the cytoplasm of many tumor cells that involve both the reproductive and non-reproductive organs. These receptors have been demonstrated in prostate and breast cancers, endometrial carcinomas, renal cell carcinoma, lymphoma, carcinoma of liver, pancreas and skin...
August 17, 2016: Hormone Molecular Biology and Clinical Investigation
T Kaşifoğlu, Ş Yaşar Bilge, F Yıldız, G Özen, Y Pehlivan, N Yılmaz, F Tarhan, S Yılmaz, A Küçük, H Emmungil, S S Koca, M Çınar, H Direskeneli, E Erken, G Can, M Özmen, E Gönüllü, B Kisacik, K Aksu, O Karadağ, N Kasifoglu, D Arslantas, F Sahin, G Keser, S Yavuz, M Birlik, A M Onat
Systemic sclerosis (SSc) is an autoimmune connective tissue disease with multisystem involvement. An increased incidence of cancer in SSc patients compared with the general population has been reported in several reports. Our aims in this study were to determine the most common malignancies and to investigate the possible risk factors for the development of malignancy in patients with SSc. Three hundred forty SSc patients from 13 centers were included to the study. Data of the patients were obtained by evaluating their medical records retrospectively...
June 2016: Clinical Rheumatology
Navid Ayoobian, Akbar Sarabi Asl, Hosein Poorbaygi, Mohammad Reza Javanshir
High-dose-rate (HDR) brachytherapy is a popular modality for treating cancers of the prostate, cervix, endometrium, breast, skin, bronchus, esophagus, and head and neck as well as soft-tissue sarcomas. Because of different source designs and licensing issues, there is a need for specific dosimetry dataset for each HDR source model. The main objective of the present work is to measure 2D relative dose distribution around a new prototype 192Ir source, referred to as IRAsource-HDR, in PMMA phantom in the framework of AAPM TG-43 and TG-55 recommendations for radial distances of 0...
2016: Journal of Applied Clinical Medical Physics
Peter D Inskip, Alice J Sigurdson, Lene Veiga, Parveen Bhatti, Cécile Ronckers, Preetha Rajaraman, Houda Boukheris, Marilyn Stovall, Susan Smith, Sue Hammond, Tara O Henderson, Tanya C Watt, Ann C Mertens, Wendy Leisenring, Kayla Stratton, John Whitton, Sarah S Donaldson, Gregory T Armstrong, Leslie L Robison, Joseph P Neglia
OBJECTIVES: The majority of childhood cancer patients now achieve long-term survival, but the treatments that cured their malignancy often put them at risk of adverse health outcomes years later. New cancers are among the most serious of these late effects. The aims of this review are to compare and contrast radiation dose-response relationships for new solid cancers in a large cohort of childhood cancer survivors and to discuss interactions among treatment and host factors. METHODS: This review is based on previously published site-specific analyses for subsequent primary cancers of the brain, breast, thyroid gland, bone and soft tissue, salivary glands, and skin among 12,268 5-year childhood cancer survivors in the Childhood Cancer Survivor Study...
March 15, 2016: International Journal of Radiation Oncology, Biology, Physics
Vijay K Ulaganathan, Bianca Sperl, Ulf R Rapp, Axel Ullrich
Variant rs351855-G/A is a commonly occurring single-nucleotide polymorphism of coding regions in exon 9 of the fibroblast growth factor receptor FGFR4 (CD334) gene (c.1162G>A). It results in an amino-acid change at codon 388 from glycine to arginine (p.Gly388Arg) in the transmembrane domain of the receptor. Despite compelling genetic evidence for the association of this common variant with cancers of the bone, breast, colon, prostate, skin, lung, head and neck, as well as soft-tissue sarcomas and non-Hodgkin lymphoma, the underlying biological mechanism has remained elusive...
December 24, 2015: Nature
Salim Al-Rahbi, Taha Al-Lawati, Suad Al-Kharusi, Sosamma Thomas, Khoula Al-Harrasi
Dermatofibrosarcoma protuberans (DFSP) of the breast is a rare skin cancer with only a few cases reported in the literature. It corresponds to approximately 1% of all soft tissue sarcomas and to less than 0.1% of all malignancies with annual incidence of 0.8-4.5 cases per million. DFSP usually affects young and middle-aged adults and it can affect any site, but most commonly the trunk and extremities. This tumor arises from the deep dermis and subcutaneous tissues and is usually locally aggressive, but rarely metastasizes...
September 2015: Oman Medical Journal
Lucie M Turcotte, John A Whitton, Debra L Friedman, Sue Hammond, Gregory T Armstrong, Wendy Leisenring, Leslie L Robison, Joseph P Neglia
PURPOSE: Survivors of childhood cancer have an increased risk for subsequent neoplasms (SNs), but the incidence beyond the age of 40 years and associations with therapeutic exposures have not been well described. PATIENTS AND METHODS: Among 14,364 survivors of childhood cancer diagnosed between 1970 and 1986, 3,171 had an attained age of 40 years or older at the time of last contact. Cumulative incidence of SNs, standardized incidence ratios (SIRs), excess absolute risk of subsequent malignant neoplasms (SMNs), and relative risks (RRs) for SMNs and nonmelanoma skin cancers were calculated...
November 1, 2015: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Andrew M Blakely, Jane McPhillips, Thomas J Miner
BACKGROUND: Surgical palliation of cancer is best defined as procedures performed with non-curative intent to improve quality of life or control symptoms of advanced malignancy. Soft tissue involvement of advanced malignancies may produce symptoms such as pain, bleeding, or odor that significantly reduce quality of life. Literature on outcomes of palliative resection of soft tissue malignancy for local or regional control is lacking. METHODS: Soft tissue resections performed with palliative intent for locoregional control were identified from a prospectively maintained palliative surgery database at a tertiary care center from January 2004 to July 2013...
April 2015: Annals of Palliative Medicine
Mary L McMaster, Ketil R Heimdal, Jennifer T Loud, Janet S Bracci, Philip S Rosenberg, Mark H Greene
Testicular germ cell tumors (TGCT) exhibit striking familial aggregation that remains incompletely explained. To improve the phenotypic definition of familial TGCT (FTGCT), we studied an international cohort of multiple-case TGCT families to determine whether first-degree relatives of FTGCT cases are at increased risk of other types of cancer. We identified 1041 first-degree relatives of TGCT cases in 66 multiple-case TGCT families from Norway and 64 from the United States (combined follow-up of 31,556 person-years)...
July 2015: Cancer Medicine
Ibou Thiam, Kwame Doh, Cherif Dial, Abdou-Magib Gaye, Chahir Kammoun, Gisèle Woto-Gaye
UNLABELLED: The elderly is defined by WHO as any individual who has a chronological age greater than or equal to 60 years. The number of elderly is growing. The scarcity of work on malignant tumor pathology elderly contrasting with the difficulty of support have raised the interest of this work. MATERIALS AND METHODS: This is a descriptive and retrospective study carried out on a periode of 5 years based on the reported analyses of all public laboratories of anatomical pathology and cytology in Dakar...
December 2014: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
Arun Kumar Arumugam Raajasekar, Anuradha Belur, Abhinav Chandra
SESSION TITLE: Cancer Student/Resident Case Report Posters IIISESSION TYPE: Medical Student/Resident Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Myeloid sarcoma is a localized extramedullary tumor composed of immature myeloid cells. It can occur in a patient with no prior history of acute myeloid leukemia[1]. It is usually seen in association with acute leukemia, myeloproliferative neoplasm, and myelodysplastic syndromes. They have a predilection for the skin, lymph nodes, small intestine, spine, and the mean time between the diagnosis and development of AML 10...
October 1, 2014: Chest
Mohamad Farid, Whee Sze Ong, Marcus Jin Fu Lee, Raaj Jeevan, Zhen Chong Ho, Alisa Noor Hidayah Sairi, Lay Tin Soh, Donald Poon, Jonathan Teh, Francis Chin, Melissa Teo, Richard Quek
BACKGROUND: Angiosarcoma (AS) is an uncommon soft tissue sarcoma with dismal prognosis that presents either cutaneously (C-AS) or non-cutaneously (NC-AS). We compared the clinical features and treatment outcomes between these 2 groups. METHODS: A single-centre study evaluating 60 AS patients between 2002 and 2012 was performed. RESULTS: The median age was 70 years. C-AS of the scalp or face comprised 66% of patients. C-AS patients were older than NC-AS (median age 74 vs...
2013: Oncology
Adalbjorg Kristbjornsdottir, Vilhjalmur Rafnsson
BACKGROUND: Residents of geothermal areas are exposed to geothermal emissions and water containing hydrogen sulphide and radon. We aim to study the association of the residence in high temperature geothermal area with the risk of cancer. METHODS: This is an observational cohort study where the population of a high-temperature geothermal area (35,707 person years) was compared with the population of a cold, non-geothermal area (571,509 person years). The cohort originates from the 1981 National Census...
2012: Environmental Health: a Global Access Science Source
Shiho Tokuhiro, Yasuhiro Ogawa, Kazuhiro Tsuzuki, Ryo Akima, Hironobu Ue, Shinji Kariya, Akihito Nishioka
The therapeutic effect of radiotherapy using linear accelerators for relatively large tumors of more than several centimeters in diameter is reduced to one third due to a large number of hypoxic tumor cells and a significant amount of anti-oxidative enzymes including peroxidase/catalase. The most effective method by which to inject hydrogen peroxide into tumor tissue was examined. This proved difficult as 3% w/v hydrogen peroxide solution (Oxydol) is an antiseptic agent for skin lesions. Thus, injection into an affected lesion may result in hydrogen peroxide soaking into a body cavity, possibly causing an intra-arterial oxygen embolism...
November 2010: Oncology Letters
Lesley Rushton, Sally J Hutchings, Lea Fortunato, Charlotte Young, Gareth S Evans, Terry Brown, Ruth Bevan, Rebecca Slack, Phillip Holmes, Sanjeev Bagga, John W Cherrie, Martie Van Tongeren
A sound knowledge base is required to target resources to reduce workplace exposure to carcinogens. This project aimed to provide an objective estimate of the burden of cancer in Britain due to occupation. This volume presents extensive analyses for all carcinogens and occupational circumstances defined as definite or probable human occupational carcinogens by the International Agency for Research on Cancer. This article outlines the structure of the supplement - two methodological papers (statistical approach and exposure assessment), eight papers presenting the cancer-specific results grouped by broad anatomical site, a paper giving industry sector results and one discussing work-related cancer-prevention strategies...
June 19, 2012: British Journal of Cancer
D Pang, G Evans, J Birch
AIMS: Although a previous study found high risk of breast cancer in mothers of children with soft tissue sarcomas, breast cancer risks in mothers of sufferers of other childhood cancers largely remain unknown. The aetiology is not fully understood. The present study explored this excess by varying type of childhood solid cancer and formulated a hypothesis. METHODS: Mothers of 2668 children with solid tumours included in the Manchester Children's Tumour Registry, 1954-96, were traced and followed up to 31 December 2000 through the UK National Health Service Central Register...
2008: Ecancermedicalscience
R Vojtísek, Z Kinkor, J Fínek
BACKGROUNDS: The cancerogenic effect of ionizing radiation was documented just several years after it started to be used as a treatment option. Ionizing radiation produces a small but detectable risk of carcinoma as well as bone and soft tissue sarcomas. Over the past 20 years angiosarcomas arising from the area of the irradiated breast have been reported with increasing frequency as the number of women undergoing the breast conserving surgery with consecutive radiotherapy has increased also...
2011: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
Melissa A Crosby, Chuma J Chike-Obi, Donald P Baumann, Justin M Sacks, Mark T Villa, Patrick B Garvey, Jesse C Selber, Barry W Feig
BACKGROUND: Primary soft-tissue sarcomas account for less than 1 percent of all breast malignancies. Many of these are associated with prior radiation therapy. Few studies have evaluated this patient population. The purpose of this study was to examine reconstruction techniques and outcomes in a cohort of patients with breast sarcoma to elucidate the optimal type and timing of reconstruction. METHODS: The authors conducted a retrospective review of all patients diagnosed and treated for soft-tissue breast sarcomas between July 1, 1988, and December 9, 2009, at a tertiary cancer center...
December 2010: Plastic and Reconstructive Surgery
L Rushton, S Bagga, R Bevan, T P Brown, J W Cherrie, P Holmes, L Fortunato, R Slack, M Van Tongeren, C Young, S J Hutchings
BACKGROUND: Prioritising control measures for occupationally related cancers should be evidence based. We estimated the current burden of cancer in Britain attributable to past occupational exposures for International Agency for Research on Cancer (IARC) group 1 (established) and 2A (probable) carcinogens. METHODS: We calculated attributable fractions and numbers for cancer mortality and incidence using risk estimates from the literature and national data sources to estimate proportions exposed...
April 27, 2010: British Journal of Cancer
(no author information available yet)
OBJECTIVE: the aim of this collaborative project of the Italian Network of Cancer Registries (Airtum; was to analyse cancer incidence and mortality trends in Italy with special reference to the period 1998-2005. METHOD: the study was based on the Airtum database, which collects and checks data from all the Airtum registries. The present study was based on 20 general and 2 specific populationbased cancer registries. Overall, we analysed 818,017 incident cases and 342,444 cancer deaths for the time period 1998-2005...
July 2009: Epidemiologia e Prevenzione
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