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https://www.readbyqxmd.com/read/28888640/a-bovine-botulism-outbreak-associated-with-a-suspected-cross-contamination-from-a-poultry-farm
#1
R Souillard, C Le Maréchal, V Ballan, F Mahé, M Chemaly, S Le Bouquin
In October 2014, an outbreak of botulism type D/C occurred on two cattle farms in close proximity. A poultry farm located nearby with no history of botulism had transferred poultry manure to both bovine farms before the beginning of the outbreak. Given this context, epidemiological investigation was conducted to determine if the poultry farm was a reservoir of C. botulinum type D/C and to identify the source of contamination on the cattle farms. Environmental samples were collected at three houses on the poultry farm (boot swabs from the surroundings, swabs from the ventilation system, boot swabs from the poultry litter and darkling beetles samples), and on the two cattle farms (silage samples, boot swabs from the cattle stalls, boot swabs from the cattle pasture and poultry manure samples)...
September 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28885167/event-triggered-distributed-control-of-nonlinear-interconnected-systems-using-online-reinforcement-learning-with-exploration
#2
Vignesh Narayanan, Sarangapani Jagannathan
In this paper, a distributed control scheme for an interconnected system composed of uncertain input affine nonlinear subsystems with event triggered state feedback is presented by using a novel hybrid learning scheme-based approximate dynamic programming with online exploration. First, an approximate solution to the Hamilton-Jacobi-Bellman equation is generated with event sampled neural network (NN) approximation and subsequently, a near optimal control policy for each subsystem is derived. Artificial NNs are utilized as function approximators to develop a suite of identifiers and learn the dynamics of each subsystem...
September 7, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28882444/tetanus-toxoid-carrier-protein-induced-t-helper-cell-responses-upon-vaccination-of-middle-aged-adults
#3
Marieke van der Heiden, Aafke Duizendstra, Guy A M Berbers, Annemieke M H Boots, Anne-Marie Buisman
INTRODUCTION: Vaccines frequently induce suboptimal immune responses in the elderly, due to immunological ageing. Timely vaccination may be a strategy to overcome this problem, which classifies middle-aged adults asan interesting target group for future vaccine interventions. However, the immunological fitness of the middle-aged population is ill-defined. It is currently unknown whether effective T-cell help towards B-cells is initiated by conjugate-carrier vaccines at middle-age. AIM: We characterized systemic Tetanus Toxoid (TT) specific T-helper cell responses in the circulation of middle-aged adults (50-65years of age, n=31) having received the MenACWY-TT vaccination...
September 4, 2017: Vaccine
https://www.readbyqxmd.com/read/28878275/a-fluorescence-based-reporter-for-monitoring-expression-of-mycobacterial-cytochrome-bd-in-response-to-antibacterials-and-during-infection
#4
Maikel Boot, Kin Ki Jim, Ting Liu, Susanna Commandeur, Ping Lu, Theo Verboom, Holger Lill, Wilbert Bitter, Dirk Bald
Cytochrome bd is a component of the oxidative phosphorylation pathway in many Gram-positive and Gram-negative bacteria. Next to its role as a terminal oxidase in the respiratory chain this enzyme plays an important role as a survival factor in the bacterial stress response. In Mycobacterium tuberculosis and related mycobacterial strains, cytochrome bd is an important component of the defense system against antibacterial drugs. In this report we describe and evaluate an mCherry-based fluorescent reporter for detection of cytochrome bd expression in Mycobacterium marinum...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28875019/protein-crystallography-and-drug-discovery-recollections-of-knowledge-exchange-between-academia-and-industry
#5
REVIEW
Tom L Blundell
The development of structure-guided drug discovery is a story of knowledge exchange where new ideas originate from all parts of the research ecosystem. Dorothy Crowfoot Hodgkin obtained insulin from Boots Pure Drug Company in the 1930s and insulin crystallization was optimized in the company Novo in the 1950s, allowing the structure to be determined at Oxford University. The structure of renin was developed in academia, on this occasion in London, in response to a need to develop antihypertensives in pharma...
July 1, 2017: IUCrJ
https://www.readbyqxmd.com/read/28872381/pneumatic-compression-fails-to-improve-performance-recovery-in-trained-cyclists
#6
Ryan G Overmayer, Matthew W Driller
PURPOSE: To examine the efficacy of Intermittent Sequential Pneumatic Compression (ISPC) on exercise recovery and subsequent performance, when implemented between a 20-min cycling bout (simulated scratch race) and a 4-min cycling test (simulated individual pursuit), as experienced during an Omnium track cycling competition. METHODS: Twenty-one (13 male, 8 female, mean ± SD; age: 36 ± 14 years) trained cyclists completed a familiarisation trial followed by two experimental trials in a counterbalanced, crossover design...
September 5, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28870688/-what-do-virtual-reality-tools-bring-to-child-and-adolescent-psychiatry
#7
S Bioulac, E de Sevin, P Sagaspe, A Claret, P Philip, J A Micoulaud-Franchi, M P Bouvard
Virtual reality is a relatively new technology that enables individuals to immerse themselves in a virtual world. It offers several advantages including a more realistic, lifelike environment that may allow subjects to "forget" they are being assessed, allow a better participation and an increased generalization of learning. Moreover, the virtual reality system can provide multimodal stimuli, such as visual and auditory stimuli, and can also be used to evaluate the patient's multimodal integration and to aid rehabilitation of cognitive abilities...
September 1, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28868591/early-ct-scanning-in-the-emergency-department-in-patients-with-penetrating-injuries-does-it-affect-outcome
#8
W J van den Hout, G M van der Wilden, F Boot, F J Idenburg, S J Rhemrev, R Hoencamp
BACKGROUND: To be a level I trauma center in the Netherlands a computed tomography (CT) scanner in the emergency department (ED) is considered desirable, as it is presumed that this optimizes the diagnostic process and that therapy can be directed based on these findings. Aim of this study was to assess the effects of implementing a CT scanner in the ED on outcomes in patients with penetrating injuries. METHODS: In this retrospective descriptive study, patients with penetrating injuries (shot and/or stab wounds), presented between 2000 and 2014 were analysed using the hospital's electronic database, and data from the West Netherlands trauma registry and the financial department...
September 4, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28854940/diesel-engine-exhaust-accelerates-plaque-formation-in-a-mouse-model-of-alzheimer-s-disease
#9
Maja Hullmann, Catrin Albrecht, Damiën van Berlo, Miriam E Gerlofs-Nijland, Tina Wahle, Agnes W Boots, Jean Krutmann, Flemming R Cassee, Thomas A Bayer, Roel P F Schins
BACKGROUND: Increasing evidence from toxicological and epidemiological studies indicates that the central nervous system is an important target for ambient air pollutants. We have investigated whether long-term inhalation exposure to diesel engine exhaust (DEE), a dominant contributor to particulate air pollution in urban environments, can aggravate Alzheimer's Disease (AD)-like effects in female 5X Familial AD (5XFAD) mice and their wild-type female littermates. Following 3 and 13 weeks exposures to diluted DEE (0...
August 30, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28845720/creativity-in-adhd-goal-directed-motivation-and-domain-specificity
#10
Nathalie Boot, Barbara Nevicka, Matthijs Baas
OBJECTIVE: This research aimed to provide explanations for the inconsistent findings regarding creativity in ADHD. METHOD: In Study 1, we assessed real-world creative achievements and intrinsic motivation during idea generation in adults with ADHD and compared these with controls. In Study 2, we manipulated competition during idea generation to investigate effects on idea originality in adults with ADHD versus controls, and assessed creativity in specific domains...
August 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28842105/early-protected-weightbearing-for-acute-ruptures-of-the-achilles-tendon-do-commonly-used-orthoses-produce-the-required-equinus
#11
Philip Ellison, Andrew Molloy, Lyndon William Mason
Conservative "functional" management of acute Achilles tendon ruptures has become increasingly popular. Critical to this is the use of the walking orthosis, which positions the ankle in equinus to allow for early weightbearing. Our aim was to test whether 2 common orthoses achieved a satisfactory equinus position. A total of 11 sequentially treated Achilles tendon ruptures were assigned to either a fixed angle walking boot with wedges (FAWW) or an adjustable external equinus-corrected brace (EEB). The lateral radiographs of the cast immobilized tendons showed a mean tibiotalar angle (TTA) of 56° (range 54° to 57°) and a mean tibio-first metatarsal angle (1MTA) of 74° (range 62° to 85°)...
September 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28841625/american-society-of-maxillofacial-surgeons-2006-to-2016-another-decade-of-excellence-in-education-and-research
#12
Gaby Doumit, Ali Totonchi, Andy Wexler, Arun K Gosain
Over the past 10 years, the American Society of Maxillofacial Surgeons (ASMS) has continued to advance to meet its mission of being the premier organization to represent maxillofacial and pediatric plastic surgery in the United States. These advances are focused on education of its members, to include the American Society of Maxillofacial Surgeons basic course, the preconference symposium, the annual meeting, two basic maxillofacial courses per year, advanced maxillofacial courses, a boot camp for craniofacial fellows, a cleft course, quarterly webinars, sponsored fellowships, a visiting professorship, and the ASMS journal...
September 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28832219/estimated-reductions-in-hospitalizations-and-deaths-from-childhood-diarrhea-following-implementation-of-rotavirus-vaccination-in-africa
#13
Minesh P Shah, Jacqueline E Tate, Jason M Mwenda, A Duncan Steele, Umesh D Parashar
Rotavirus is the leading cause of hospitalizations and deaths from diarrhea. 33 African countries had introduced rotavirus vaccines by 2016. We estimate reductions in rotavirus hospitalizations and deaths for countries using rotavirus vaccination in national immunization programs and the potential of vaccine introduction across the continent. Areas covered: Regional rotavirus burden data were reviewed to calculate hospitalization rates, and applied to under-5 population to estimate baseline hospitalizations...
September 4, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28830399/why-older-workers-work-beyond-the-retirement-age-a-qualitative-study
#14
Ranu Sewdas, Astrid de Wind, Lennart G L van der Zwaan, Wieke E van der Borg, Romy Steenbeek, Allard J van der Beek, Cécile R L Boot
BACKGROUND: The aims of the present study were to: 1) gain insight into reasons for working beyond the statutory retirement age from older workers' perspectives, and 2) explore how the domains of the research framework Study on Transitions in Employment, Ability and Motivation (STREAM) can be applied to working beyond retirement age. METHODS: A qualitative research design included individual interviews (n = 15) and three focus groups (n = 18 participants) conducted with older workers aged 65 years and older continuing in a paid job or self-employment...
August 22, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28827182/surgical-practical-skills-learning-curriculum-implementation-and-interns-confidence-perceptions
#15
Danilo Acosta, Manuel Castillo-Angeles, Alejandro Garces-Descovich, Ammara A Watkins, Alok Gupta, Jonathan F Critchlow, Tara S Kent
OBJECTIVE: To provide an overview of the practical skills learning curriculum and assess its effects over time on the surgical interns' perceptions of their technical skills, patient management, administrative tasks, and knowledge. DESIGN: An 84-hour practical skills curriculum composed of didactic, simulation, and practical sessions was implemented during the 2015 to 2016 academic year for general surgery interns. Totally, 40% of the sessions were held during orientation, whereas the remainder sessions were held throughout the academic year...
August 18, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28821251/evaluation-of-different-diagnostic-methods-for-the-detection-of-mycobacterium-avium-subsp-paratuberculosis-in-boot-swabs-and-liquid-manure-samples
#16
Nathalie Hahn, Klaus Failing, Tobias Eisenberg, Karen Schlez, Peter-Michael Zschöck, Karsten Donat, Esra Einax, Heike Köhler
BACKGROUND: Environmental sampling based on boot swabs and/or liquid manure samples is an upcoming strategy for the identification of paratuberculosis (paraTB) positive herds, but only limited data are available regarding the diagnostic performance of molecular detection methods (qPCR) versus faecal culture (FC) for this purpose. In the present study, the test characteristics of two different qPCR protocols (A and B) and a standardized FC protocol, for the detection of Mycobacterium avium subsp...
August 18, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28817162/determining-when-it-is-safe-to-remove-the-external-fixator-results-from-a-survey-of-the-limb-lengthening-and-reconstruction-society
#17
Christopher A Iobst, Waleed Mohammed, Ryan Colley
Thousands of external fixators are applied for distraction osteogenesis each year. Determining when it is safe to remove the fixator can be difficult. The purpose of this study was to survey an international group of external fixation surgeons to determine their current practice patterns surrounding external fixator removal. A 10-question, open-ended survey was emailed to members of the Limb Lengthening and Reconstruction Society. Responses were recorded, and statistical analysis was performed. Pearson's chi-square test and likelihood ratio were used when indicated...
August 17, 2017: Orthopedics
https://www.readbyqxmd.com/read/28810991/posterior-cruciate-ligament-injuries-associated-with-military-survival-swim-training
#18
Michael S Crowell, John S Mason, Matthew A Posner, Chad A Haley
OBJECTIVES: Posterior cruciate ligament (PCL) injuries are relatively common injuries associated with athletic activities and high-energy trauma. Posterolateral corner (PLC) injuries frequently accompany injury to the PCL. Diagnosis can be challenging and requires a comprehensive history and physical examination. Patients frequently report vague, nonspecific symptoms and the mechanism of injury is often useful in localizing injured structures. Two of the more common mechanisms for PCL injury include a direct blow to the proximal anterior tibia with the knee flexed, as well as a significant knee hyperextension injury...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810501/relational-resilience-as-a-potential-mediator-between-adverse-childhood-experiences-and-prenatal-depression
#19
Kathryn H Howell, Laura E Miller-Graff, Lauren M Schaefer, Kathryn E Scrafford
This study examined the indirect effects of individual, relational, and contextual resilience in the relationship between adverse childhood experiences and prenatal depression. Participants included 101 pregnant women. Adverse childhood experiences had a direct effect on depression, B = 1.11, standard error = .44, p = .01, and relational resilience, B = -1.15, standard error = .19, p < .001, but not individual or contextual resilience. With resilience as a mediator, the effect of adverse childhood experiences on depression was no longer significant...
August 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28810352/maternal-responses-to-difficult-food-request-scenarios-relationships-with-feeding-style-and-child-unhealthy-snack-intake
#20
Samantha B Boots, Marika Tiggemann, Nadia Corsini
This study sought to identify parent-feeding behaviours in real-life difficult feeding situations through the use of a set of scenarios. These were then used to examine links between parent feeding and child snack intake. Mothers of children aged 2-7 years ( n = 611) completed an online survey containing five snack food request scenarios, two commonly used parent-feeding scales (Restriction and Covert Control), and reported on their child's snack intake. Results showed that parent-feeding styles (restrictive or covert) translated into specific behaviours in response to the scenarios...
October 1, 2016: Journal of Health Psychology
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