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https://www.readbyqxmd.com/read/29313438/is-the-recreational-use-of-3-4-methylenedioxy-methamphetamine-safe
#1
Toby Boote
3,4-methylenedioxy-methamphetamine is taken recreationally by thousands of people, especially the young, across the globe. It is highly associated with electronic music and its use in the UK remains high at around 4.5% of 16-24 year olds. This review discusses both the short- and long-term effects of 3,4-methylenedioxy-methamphetamine including methods by which some of these adverse effects can be prevented or even reversed to increase the safety of the commonly used drug.
January 1, 2018: Medico-legal Journal
https://www.readbyqxmd.com/read/29304466/uptake-transportation-and-accumulation-of-c60-fullerene-and-heavy-metal-ions-cd-cu-and-pb-in-rice-plants-grown-in-an-agricultural-soil
#2
Chuanzhou Liang, Haijun Xiao, Ziqi Hu, Xu Zhang, Jun Hu
The mutual influences of C60 fullerene (C60) and heavy metal ions (Cd, Cu, and Pb) on the uptake, transportation, and accumulation of these coexisting pollutants in four rice cultivars planted in agricultural soil were investigated during the whole life cycle of rice. The biomass of the rice plants was not affected significantly by the presence of C60. C60 exposure exerted different impacts on the bioaccumulation of Cd, Cu, and Pb in various rice tissues. For example, the bioaccumulation of Cd in rice 9311 panicles was significantly decreased (p < ...
January 2, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29295031/college-students-beliefs-about-domestic-violence-a-replication-and-extension
#3
Shelly M Wagers, Jennifer Wareham, Denise Paquette Boots
In recent decades, significant effort and money have been spent to change social and legal responses to domestic violence and affect public perceptions. A small body of research has examined individuals' opinions about what behaviors are considered domestic violence. Using a sample of college students, the present study examined a modified version of a somewhat popular instrument used to measure beliefs about domestic violence, extending previous work done by Carlson and Worden. Results indicated beliefs about domestic violence are multidimensional, depending on the nature of the behavior and, in part, the gender of the perpetrator...
December 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29288908/the-role-of-military-footwear-and-workload-on-ground-reaction-forces-during-a-simulated-lateral-ankle-sprain-mechanism
#4
Jeffrey D Simpson, Hunter DeBusk, Christopher Hill, Adam Knight, Harish Chander
BACKGROUND: Ankle sprains are a common orthopedic injury in military populations, which may be attributed to occupational demands and footwear. Minimalist military boots have become popular, but their influence on ground reaction force (GRF) attenuation capabilities during an ankle inversion perturbation are unknown. Therefore, the purpose of this study was to examine potential differences in GRFs during an ankle inversion perturbation in a standard issue (STN) and minimalist military boot (MIN) before and after a simulated military workload...
November 22, 2017: Foot
https://www.readbyqxmd.com/read/29287771/lower-antibody-functionality-in-middle-aged-adults-compared-to-adolescents-after-primary-meningococcal-vaccination-role-of-igm
#5
Marieke van der Heiden, Mariette B van Ravenhorst, Marjan Bogaard, Annemieke M H Boots, Guy A M Berbers, Anne-Marie Buisman
INTRODUCTION: Successful vaccination of elderly persons is often hampered by immunological ageing, leaving part of the elderly population vulnerable for infectious diseases. As an alternative, timely vaccinations might be administered at middle-age, before reaching old age. Studies evaluating the immunological fitness of middle-aged adults are warranted. In this study we compared the immunogenicity of a primary meningococcal vaccination in Dutch middle-aged adults with that in adolescents, in order to gain knowledge on the early signs of immune ageing...
December 26, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29282606/appraisal-support-from-natural-mentors-self-worth-and-psychological-distress-examining-the-experiences-of-underrepresented-students-transitioning-through-college
#6
Noelle M Hurd, Jamie Albright, Audrey Wittrup, Andrea Negrete, Janelle Billingsley
The current study explored whether cumulative appraisal support from as many as five natural mentors (i.e., nonparental adults from youth's pre-existing social networks who serve a mentoring role in youth's lives) led to reduced symptoms of depression and anxiety via improved global self-worth among underrepresented college students. Participants in the current study included 340 college students (69% female) attending a 4-year, predominantly White institution of higher education. Participants were first-generation college students, students from economically disadvantaged backgrounds, and/or students from underrepresented racial/ethnic minority groups...
December 27, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/29281637/cell-envelope-stress-in-mycobacteria-is-regulated-by-the-novel-signal-transduction-atpase-inir-in-response-to-trehalose
#7
Maikel Boot, Vincent J C van Winden, Marion Sparrius, Robert van de Weerd, Alexander Speer, Roy Ummels, Tige Rustad, David R Sherman, Wilbert Bitter
The cell envelope of mycobacteria is a highly unique and complex structure that is functionally equivalent to that of Gram-negative bacteria to protect the bacterial cell. Defects in the integrity or assembly of this cell envelop must be sensed to allow the induction of stress response systems. The promoter that is specifically and most strongly induced upon exposure to ethambutol and isoniazid, first line drugs that affect cell envelope biogenesis, is the iniBAC promoter. In this study, we set out to identify the regulator of the iniBAC operon in Mycobacterium marinum using an unbiased transposon mutagenesis screen in a constitutively iniBAC-expressing mutant background...
December 27, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29279186/digital-dermatitis-in-dairy-cattle-the-contribution-of-different-disease-classes-to-transmission
#8
Floor Biemans, Piter Bijma, Natasja M Boots, Mart C M de Jong
Digital Dermatitis (DD) is a claw disease mainly affecting the hind feet of dairy cattle. Digital Dermatitis is an infectious disease, transmitted via the environment, where the infectious "agent" is a combination of bacteria. The standardized classification for DD lesions developed by Döpfer et al. (1997) and extended by Berry et al. (2012) has six distinct classes: healthy (M0), an active granulomatous area of 0-2 cm (M1), an ulcerative lesion of >2 cm (M2), an ulcerative lesion covered by a scab (M3), alteration of the skin (M4), and a combination of M4 and M1 (M4...
December 22, 2017: Epidemics
https://www.readbyqxmd.com/read/29276521/simulated-optimum-sowing-date-for-forage-pearl-millet-cultivars-in-multilocation-trials-in-brazilian-semi-arid-region
#9
Rafael D Santos, Kenneth J Boote, Lynn E Sollenberger, Andre L A Neves, Luiz G R Pereira, Carolina B Scherer, Lucio C Gonçalves
Forage production is primarily limited by weather conditions under dryland production systems in Brazilian semi-arid regions, therefore sowing at the appropriate time is critical. The objectives of this study were to evaluate the CSM-CERES-Pearl Millet model from the DSSAT software suite for its ability to simulate growth, development, and forage accumulation of pearl millet [Pennisetum glaucum (L.) R.] at three Brazilian semi-arid locations, and to use the model to study the impact of different sowing dates on pearl millet performance for forage...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29275274/the-effects-of-exit-from-work-on-health-across-different-socioeconomic-groups-a-systematic-literature-review
#10
REVIEW
Rosanne Schaap, Astrid de Wind, Pieter Coenen, Karin Proper, Cécile Boot
Exit from work leads to different effects on health, partially depending on the socioeconomic status (SES) of people in the work exit. Several studies on the effects of exit from work on health across socioeconomic groups have been performed, but results are conflicting. The aim of this review is to systematically review the available evidence regarding the effects of exit from work on health in high and low socioeconomic groups. A systematic literature search was conducted using Pubmed, Embase, Web of Science, CINAHL and PsycINFO...
December 12, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29273645/stratification-of-knee-osteoarthritis-two-major-patient-subgroups-identified-by-genome-wide-expression-analysis-of-articular-cartilage
#11
Jamie Soul, Sara L Dunn, Sanjay Anand, Ferdinand Serracino-Inglott, Jean-Marc Schwartz, Ray P Boot-Handford, Tim E Hardingham
INTRODUCTION: Osteoarthritis (OA) is a heterogeneous and complex disease. We have used a network biology approach based on genome-wide analysis of gene expression in OA knee cartilage to seek evidence for pathogenic mechanisms that may distinguish different patient subgroups. METHODS: Results from RNA-Sequencing (RNA-Seq) were collected from intact knee cartilage at total knee replacement from 44 patients with OA, from 16 additional patients with OA and 10 control patients with non-OA...
December 22, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29258980/implementation-of-the-blended-care-self-management-program-for-caregivers-of-people-with-early-stage-dementia-partner-in-balance-process-evaluation-of-a-randomized-controlled-trial
#12
Lizzy Mm Boots, Marjolein E de Vugt, Claudia Mj Smeets, Gertrudis Ijm Kempen, Frans Rj Verhey
BACKGROUND: Caring for a family member with dementia puts caregivers at risk of overburdening. Electronic health (eHealth) support for caregivers offers an opportunity for accessible tailored interventions. The blended care self-management program "Partner in Balance" (PiB) for early-stage dementia caregivers was executed in Dutch dementia care organizations. The program combines face-to-face coaching with tailored Web-based modules. Next to an evaluation of program effectiveness, an evaluation of sampling and intervention quality is essential for the generalizability and interpretation of results...
December 19, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29258720/safety-of-intraperitoneal-mitomycin-c-versus-intraperitoneal-oxaliplatin-in-patients-with-peritoneal-carcinomatosis-of-colorectal-cancer-undergoing-cytoreductive-surgery-and-hipec
#13
W J van Eden, N F M Kok, K Woensdregt, A D R Huitema, H Boot, A G J Aalbers
BACKGROUND: Colorectal peritoneal carcinomatosis (PC) is commonly treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). There is an ongoing international debate about which intraperitoneal chemotherapeutic agent is preferred, Mitomycin C (MMC) or oxaliplatin. We questioned whether the type of chemotherapeutic agent influenced postoperative complication rates or short-term survival. METHODS: In this retrospective cohort study patients with colorectal PC who underwent CRS-HIPEC between January 2010 and December 2016 were included...
November 15, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29250926/subepidermal-moisture-detection-of-heel-pressure-injury-the-pressure-ulcer-detection-study-outcomes
#14
Barbara M Bates-Jensen, Heather E McCreath, Gojiro Nakagami, Anabel Patlan
We examined subepidermal moisture (SEM) and visual skin assessment of heel pressure injury (PrI) among 417 nursing home residents in 19 facilities over 16 weeks. Participants were older (mean age 77 years), 58% were female, over half were ethnic minorities (29% African American, 12% Asian American, 21% Hispanic), and at risk for PrI (mean Braden Scale Risk score = 15.6). Blinded concurrent visual assessments and SEM measurements were obtained at heels weekly. Visual skin damage was categorised as normal, erythema, stage 1 PrI, deep tissue injury (DTI) or stage 2 or greater PrI...
December 17, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29245303/viable-placental-allograft-as-a-biological-dressing-in-the-clinical-management-of-full-thickness-thermal-occupational-burns-two-case-reports
#15
Eric L Johnson, Elisabet K Tassis, Georgina M Michael, Susan G Whittinghill
RATIONALE: Occupational burn injuries can be detrimental and difficult to manage. The majority of complex cases are referred and managed at regional burn centers where access to specialized care is available. As an alternative to hospitalization with staged surgical procedures, placental products may be used for outpatient medical management of these common burn injuries, especially if access to a regional burn center is limited or restricted.Fresh amnion has been a treatment of choice in burns for more than 100 years...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29244523/hip-distraction-without-a-perineal-post-a-prospective-study-of-1000-hip-arthroscopy-cases
#16
Omer Mei-Dan, Matthew J Kraeutler, Tigran Garabekyan, Jesse A Goodrich, David A Young
BACKGROUND: Hip arthroscopy has traditionally been performed with a perineal post, resulting in various groin-related complications, including pudendal nerve neurapraxias, vaginal tears, and scrotal necrosis. PURPOSE: To assess the safety of a technique for hip distraction without the use of a perineal post. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: We prospectively analyzed a consecutive cohort of 1000 hips presenting to a dedicated hip preservation clinic; all patients had hip pain and were subsequently treated with hip arthroscopy...
December 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29241206/a-multicenter-experience-with-long-acting-somatostatin-analogues-in-patients-with-congenital-hyperinsulinism
#17
Ivo van der Steen, Mirjam E van Albada, Klaus Mohnike, Henrik Thybo Christesen, Susann Empting, Maria Salomon-Estebanez, Amalie Greve Rasmussen, Annemarie Verrijn Stuart, Annelieke A A van der Linde, Indraneel Banerjee, Annemieke M Boot
BACKGROUND/AIMS: Congenital hyperinsulinism (CHI) is a rare disease characterized by recurrent severe hypoglycemia. In the diffuse form of CHI, pharmacotherapy is the preferred choice of treatment. Long-acting somatostatin analogues have been used in children as off-label medication. However, the efficacy, outcomes, and adverse effect profiles of long-acting somatostatin analogues have not been described in multicentered studies. The aim of this retrospective study is to summarize the experience with long-acting somatostatin analogues in a large group of children with CHI...
December 14, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29239204/john-hunter-s-operation-for-popliteal-aneurysm
#18
Harold Ellis
An aneurysm is defined as a "sac communicating with the lumen of an artery" and the treatment of the various types of this disease has intrigued surgeons through the ages. Aneurysms of the popliteal artery today are fairly uncommon. However, in the 18th century they were quite frequently encountered, many of them in coach drivers. We can only surmise that this was the result of repetitive trauma to the artery, already the seat of arteriosclerosis, against the rim at the top of the long leather riding boot which was worn at that time...
June 2017: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29233442/preparing-students-for-residency-interviews-through-a-residency-interview-boot-camp
#19
Timothy R Ulbrich, Jaclyn A Boyle
BACKGROUND AND PURPOSE: To describe the offering of the residency boot camp activity at one college of pharmacy for students in their fourth professional year. EDUCATIONAL ACTIVITY AND SETTING: Student pharmacists in their final professional year of pharmacy school were invited to participate in a voluntary residency boot camp activity. Originally, the activity consisted of four parts: (1) guidance on preparing for residency interviews; (2) a 1:1 mock interview with a resident, faculty member, residency preceptor or area program director; (3) a review of the student's curriculum vitae (CV) and letter of intent; and (4) a review of the application timeline and process...
July 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29227892/effects-of-rare-earth-and-acid-rain-pollution-on-plant-chloroplast-atp-synthase-and-element-contents-at-different-growth-stages
#20
Fan Zhang, Huiqing Hu, Lihong Wang, Qing Zhou, Xiaohua Huang
Combined rare earth and acid rain pollution has become a new environmental problem, seriously affecting plant survival. The effects of these two kinds of pollutants on plant photosynthesis have been reported, but the micro mechanisms are not very clear. In this research, we studied the effects of lanthanum [La(III), 0.08, 1.20 and 2.40 mM] and acid rain (pH value = 2.5, 3.5 and 4.5) on the ATPase activity and gene transcription level and the functional element contents in rice leaf chloroplasts. The results showed that the combined 0...
December 1, 2017: Chemosphere
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