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https://www.readbyqxmd.com/read/29777617/simulation-in-urology-to-train-non-technical-skills-in-ward-rounds
#1
K Somasundram, H Spence, A J Colquhoun, C Mcilhenny, C S Biyani, S Jain
OBJECTIVE: We have designed an exercise to train newly appointed Urology trainees in non-technical skills on ward rounds as a part of a simulation 'boot camp'. This paper reports our experience, including a qualitative analysis of participant feedback on the utility of this method of training. PATIENTS AND METHODS: The simulations took place in a high-fidelity simulated ward bay. Forty-eight doctors with formal Urology training ranging between 2-60 months (mean 19...
May 19, 2018: BJU International
https://www.readbyqxmd.com/read/29777584/neuropsychiatric-expression-and-catatonia-in-22q11-2-deletion-syndrome-an-overview-and-case-series
#2
Nancy J Butcher, Erik Boot, Anthony E Lang, Danielle Andrade, Jacob Vorstman, Donna McDonald-McGinn, Anne S Bassett
Individuals with 22q11.2 deletion syndrome (22q11.2DS) are at elevated risk of developing treatable psychiatric and neurological disorders, including anxiety disorders, schizophrenia, seizures, and movement disorders, often beginning in adolescence or early to mid-adulthood. Here, we provide an overview of neuropsychiatric features associated with 22q11.2DS in adulthood. Results of a new case series of 13 individuals with 22q11.2DS and catatonic features together with 5 previously reported cases support a potential association of this serious psychomotor phenotype with the 22q11...
May 19, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29775166/aluminum-foot-insoles-reduce-plantar-forefoot-pressure-and-increase-foot-comfort-for-motorcyclists
#3
Israel Casado-Hernández, Ricardo Becerro-de-Bengoa-Vallejo, Daniel López-López, Antonio Gómez-Bernal, Marta Elena Losa-Iglesias
BACKGROUND: Foot pain and paresthesia are common in cycling, due to plantar pressure and repetitive loading. OBJECTIVES: The aim was to investigate the effect of foot insoles on plantar pressure of the foot in motorcycling, as well as self-reported comfort. STUDY DESIGN: A randomized crossover clinical trial. METHODS: A flexible foot pressure mat (GP MobilData WiFi® Gebiomized®) with different sizes was utilized. RESULTS: Maximum pressure values occurred predominantly in the hallux with 4...
May 1, 2018: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/29772940/assistive-technology-and-people-a-position-paper-from-the-first-global-research-innovation-and-education-on-assistive-technology-great-summit
#4
Deirdre Desmond, Natasha Layton, Jacob Bentley, Fleur Heleen Boot, Johan Borg, Bishnu Maya Dhungana, Pamela Gallagher, Lynn Gitlow, Rosemary Joan Gowran, Nora Groce, Katerina Mavrou, Trish Mackeogh, Rachael McDonald, Cecilia Pettersson, Marcia Scherer
Assistive technology (AT) is a powerful enabler of participation. The World Health Organization's Global Collaboration on Assistive Technology (GATE) programme is actively working towards access to assistive technology for all. Developed through collaborative work as a part of the Global Research, Innovation and Education on Assistive Technology (GREAT) Summit, this position paper provides a "state of the science" view of AT users, conceptualized as "People" within the set of GATE strategic "P"s...
May 17, 2018: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29772906/visualization-and-semi-quantity-study-of-the-distribution-of-ma-jor-components-in-wheat-straw-in-mesoscopic-scale-using-ftir-microspectroscopic-imaging
#5
Zengling Yang, Jiaqi Mei, Zhiqiang Liu, Guangqun Huang, Guan Huang, Lujia Han
Understanding the biochemical heterogeneity of plant tissue linked to crop straw anatomy is attractive to plant researchers and researchers in the field of biomass-refinery. This study provides an in-situ analysis and semi-quantitative, visualization distributions of major composition distribution in internodal transverse sections of wheat straw based on FTIR microspec-troscopic imaging, with a fast Non-Negativity-Constrained Least Squares (fast NNLS) fitting. The paper investigates changes in biochemical components of tissue during stages of elongation, booting, heading, flowering, grain-filling, milk-ripening, dough, and full-ripening...
May 18, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29768043/haptic-foot-pedal-influence-of-shoe-type-age-and-gender-on-subjective-pulse-perception
#6
Claudia Geitner, Stewart Birrell, Claudia Krehl, Paul Jennings
OBJECTIVE: This study investigates the influence of shoe type (sneakers and safety boots), age, and gender on the perception of haptic pulse feedback provided by a prototype accelerator pedal in a running stationary vehicle. BACKGROUND: Haptic feedback can be a less distracting alternative to traditionally visual and auditory in-vehicle feedback. However, to be effective, the device delivering the haptic feedback needs to be in contact with the person. Factors such as shoe type vary naturally over the season and could render feedback that is perceived well in one situation, unnoticeable in another...
June 2018: Human Factors
https://www.readbyqxmd.com/read/29764927/identification-of-genes-related-to-cold-tolerance-and-a-functional-allele-that-confers-cold-tolerance
#7
Ning Xiao, Yong Gao, Huangjun Qian, Qiang Gao, Yunyu Wu, Dongping Zhang, Zhiping Wang, Xiaoxiang Zhang, Ling Yu, Yuhong Li, Cunhong Pan, Guangqing Liu, Changhai Zhou, Min Jiang, Niansheng Huang, Zhuo Chen, Chengzhi Liang, Zhengyuan Dai, Jianmin Chen, Aihong Li
Cold stress is a major factor limiting rice (Oryza sativa L.) production worldwide, especially at the seedling and booting stages. Identification of genes associated with cold tolerance (CT) in rice is important for sustainable food production. Here, we report the results of a genome-wide association study (GWAS) to identify the genetic loci associated with CT by using a 1,033-accession diversity panel. We identified five CT-related genetic loci at the booting stage. Accessions carrying multiple cold-tolerant alleles displayed a higher seed setting rate than did accessions that had no cold-tolerant alleles or carried a single allele...
May 15, 2018: Plant Physiology
https://www.readbyqxmd.com/read/29752688/field-guide-to-boot-camp-curriculum-development
#8
Dawnelle Schatte, Gretchenjan Gavero, Lia Thomas, Jessica Kovach
No abstract text is available yet for this article.
May 11, 2018: Academic Psychiatry
https://www.readbyqxmd.com/read/29752303/typical-features-of-parkinson-disease-and-diagnostic-challenges-with-microdeletion-22q11-2
#9
Erik Boot, Nancy J Butcher, Sean Udow, Connie Marras, Kin Y Mok, Satoshi Kaneko, Matthew J Barrett, Paolo Prontera, Brian D Berman, Mario Masellis, Boris Dufournet, Karine Nguyen, Perrine Charles, Eugénie Mutez, Teodor Danaila, Aurélia Jacquette, Olivier Colin, Sophie Drapier, Michel Borg, Ania M Fiksinski, Elfi Vergaelen, Ann Swillen, Annick Vogels, Annika Plate, Claudia Perandones, Thomas Gasser, Kristien Clerinx, Frédéric Bourdain, Kelly Mills, Nigel M Williams, Nicholas W Wood, Jan Booij, Anthony E Lang, Anne S Bassett
OBJECTIVE: To delineate the natural history, diagnosis, and treatment response of Parkinson disease (PD) in individuals with 22q11.2 deletion syndrome (22q11.2DS), and to determine if these patients differ from those with idiopathic PD. METHODS: In this international observational study, we characterized the clinical and neuroimaging features of 45 individuals with 22q11.2DS and PD (mean follow-up 7.5 ± 4.1 years). RESULTS: 22q11.2DS PD had a typical male excess (32 male, 71...
May 11, 2018: Neurology
https://www.readbyqxmd.com/read/29752219/immediate-weightbearing-after-first-metatarsophalangeal-joint-arthrodesis-with-screw-and-locking-plate-fixation-a-short-term-review
#10
Kyle W Abben, Matthew D Sorensen, Brett J Waverly
Historically, the postoperative protocol for patients undergoing first metatarsophalangeal joint arthrodesis has included 6 weeks of non-weightbearing, followed by protected weightbearing in a below-the-knee cast boot or postoperative shoe. This prolonged period of non-weightbearing predisposes the patient to disuse atrophy, osteopenia, deep vein thrombosis risk, and, overall, a prolonged time to recovery. The present study reports a retrospective review of a patient cohort that underwent first metatarsophalangeal joint fusion with immediate full weightbearing postoperatively...
May 8, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29749044/mycobacteria-employ-two-different-mechanisms-to-cross-the-blood-brain-barrier
#11
L M van Leeuwen, M Boot, C Kuijl, D I Picavet, G van den Brink, S M A van der Pol, H E de Vries, N N van der Wel, M van der Kuip, A M van Furth, A M van der Sar, W Bitter
Central nervous system (CNS) infection by Mycobacterium tuberculosis is one of the most devastating complications of tuberculosis, in particular in early childhood. In order to induce CNS infection, M. tuberculosis needs to cross specialized barriers protecting the brain. How M. tuberculosis crosses the blood-brain barrier (BBB) and enters the CNS is not well understood. Here, we use transparent zebrafish larvae and the closely related pathogen Mycobacterium marinum to answer this question. We show that in the early stages of development mycobacteria rapidly infect brain tissue, either as free mycobacteria or within circulating macrophages...
May 10, 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/29745852/transcriptomic-and-metabolic-flux-analyses-reveal-shift-of-metabolic-patterns-during-rice-grain-development
#12
Fangzhou Shen, Xueting Wu, Luoxi Shi, Hang Zhang, Yangmin Chen, Xiaoquan Qi, Zhuo Wang, Xuan Li
BACKGROUND: Rice (Oryza sativa) is one of the most important grain crops, which serves as food source for nearly half of the world population. The study of rice development process as well as related strategies for production has made significant progress. However, the comprehensive study on development of different rice tissues at both transcriptomic and metabolic flux level across different stages was lacked. RESULTS: In this study, we performed RNA-Seq and characterized the expression profiles of differentiated tissues from Oryza sativa Zhonghua 11, including leaves, sheath, stamen, pistil, lemma and palea of the booting stage, and embryo, endosperm, lemma and palea of the mature grain stage...
April 24, 2018: BMC Systems Biology
https://www.readbyqxmd.com/read/29738281/epidemiology-of-figure-skating-injuries-a-review-of-the-literature
#13
Julie S Han, Ellen T Geminiani, Lyle J Micheli
CONTEXT: As the popularity and technical demands of figure skating increase, so will the number of athletes presenting with sport-related problems. EVIDENCE ACQUISITION: Searches were performed across PubMed from 1980 to 2017. The keywords searched were skating, skaters, incidence, and injuries. The search was limited to English-language articles and human participants. Relevant articles were cross-referenced. STUDY DESIGN: Clinical review...
May 1, 2018: Sports Health
https://www.readbyqxmd.com/read/29737194/characterization-of-cellular-immune-responses-in-thai-individuals-with-and-without-hiv-associated-neurocognitive-disorders
#14
Silvia Ratto-Kim, Alexandra Schuetz, Pasiri Sithinamsuwan, John Barber, Nicholas Hutchings, Sukalaya Lerdlum, James L K Fletcher, Yuwadee Phuang-Ngern, Weerawan Chuenarom, Somporn Tipsuk, Mantana Pothisri, Tanate Jadwattanakul, Supunnee Jirajariyavej, Chayada Sajjaweerawan, Siriwat Akapirat, Thep Chalermchai, Duanghathai Suttichom, Boot Keawboon, Peeriya Prueksakaew, Putthachard Karnsomlap, David Clifford, Robert H Paul, Mark de Souza, Jerome H Kim, Jintinant Anaworanich, Victor Valcour
HIV-associated cognitive disorder (HAND) remains a challenge despite antiretroviral therapy (ART), and has been linked to monocyte/macrophage (M/M) migration to the brain. Due to the potential impact of T cell effector mechanisms in eliminating activated/HIV-infected M/M, T cell activation may play a role in the development of HAND. We sought to investigate the relationship between cognition and both CD8+ T-cell activation (HLA-DR+/CD38+) and HIV-specific CD8+ T-cell responses at the time of HIV diagnosis and 12 months post initiation of ART...
May 8, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29727173/cigarette-filter-ventilation-and-smoking-protocol-influence-aldehyde-smoke-yields
#15
Charlotte G G M Pauwels, Walther N M Klerx, Jeroen L A Pennings, Agnes W Boots, Frederik Jan van Schooten, Antoon Opperhuizen, Reinskje Talhout
The WHO Study Group on Tobacco Product Regulation (TobReg) advised regulating and lowering toxicant levels in cigarette smoke. Aldehydes are one of the chemical classes on the TobReg smoke toxicants priority list. To provide insight in factors determining aldehyde yields, the levels of 12 aldehydes in mainstream cigarette smoke of 11 Dutch brands were quantified. Variations in smoking behavior and cigarette design affecting human exposure to aldehydes were studied by using four different machine testing protocols...
May 4, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29725623/melioidosis-in-thailand-present-and-future
#16
Soawapak Hinjoy, Viriya Hantrakun, Somkid Kongyu, Jedsada Kaewrakmuk, Tri Wangrangsimakul, Siroj Jitsuronk, Weerawut Saengchun, Saithip Bhengsri, Thantapat Akarachotpong, Somsak Thamthitiwat, Ornuma Sangwichian, Siriluck Anunnatsiri, Rasana W Sermswan, Ganjana Lertmemongkolchai, Chayada Sitthidet Tharinjaroen, Kanya Preechasuth, Ratchadaporn Udpaun, Poomin Chuensombut, Nisarat Waranyasirikul, Chanihcha Anudit, Surapong Narenpitak, Yaowaruk Jutrakul, Prapit Teparrukkul, Nittaya Teerawattanasook, Kittisak Thanvisej, Alisa Suphan, Punchawee Sukbut, Kritchavat Ploddi, Poolsri Sirichotirat, Bongkoch Chiewchanyon, Kamolchanok Rukseree, Maliwan Hongsuwan, Gumphol Wongsuwan, Pornpan Sunthornsut, Vanaporn Wuthiekanun, Sandy Sachaphimukh, Prapass Wannapinij, Wirongrong Chierakul, Claire Chewapreecha, Janjira Thaipadungpanit, Narisara Chantratita, Sunee Korbsrisate, Apichai Taunyok, Susanna Dunachie, Prasit Palittapongarnpim, Stitaya Sirisinha, Rungrueng Kitphati, Sopon Iamsirithaworn, Wipada Chaowagul, Ploenchan Chetchotisak, Toni Whistler, Surasakdi Wongratanacheewin, Direk Limmathurotsakul
A recent modelling study estimated that there are 2800 deaths due to melioidosis in Thailand yearly. The Thailand Melioidosis Network (formed in 2012) has been working closely with the Ministry of Public Health (MoPH) to investigate and reduce the burden of this disease. Based on updated data, the incidence of melioidosis is still high in Northeast Thailand. More than 2000 culture-confirmed cases of melioidosis are diagnosed in general hospitals with microbiology laboratories in this region each year. The mortality rate is around 35%...
2018: Tropical Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29725326/impact-of-aging-on-the-frequency-phenotype-and-function-of-cd161-expressing-t-cells
#17
Kornelis S M van der Geest, Bart-Jan Kroesen, Gerda Horst, Wayel H Abdulahad, Elisabeth Brouwer, Annemieke M H Boots
Immune-aging is associated with perturbed immune responses in the elderly. CD161-expressing T cells, i.e., the previously described subsets of CD161+ CD4+ T cells, CD161high CD8+ T cells, and CD161int CD8+ T cells, are highly functional, pro-inflammatory T cells. These CD161-expressing T cells are critical in immunity against microbes, while possibly contributing to autoimmune diseases. So far, little is known about the impact of aging on the frequency, phenotype, and function of these CD161-expressing T cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29716995/structural-determinants-in-a-glucose-containing-lipopolysaccharide-from-mycobacterium-tuberculosis-critical-for-inducing-a-subset-of-protective-t-cells
#18
Prithwiraj De, Michael McNeil, Mei Xia, Claudia M Boot, Danny C Hesser, Karolien Denef, Christopher Rithner, Tyler Sours, Karen M Dobos, Daniel Hoft, Delphi Chatterjee
Mycobacteria synthesize intracellular, methylated glucose-containing lipopolysaccharides (mGLP) proposed to modulate bacterial fatty acid metabolism. Recently, it has been shown that Mycobacterium tuberculosis mGLP specifically induces a specific subset of protective γ9 δ2 T cells. Mild base treatment, which removes all the base-labile groups, reduces the specific activity of mGLP required for induction of these T cells, suggesting that acylation of the saccharide moieties is required for γ9 δ2 T-cell activation...
May 1, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29713520/gene-expression-in-the-three-spined-stickleback-gasterosteus-aculeatus-of-marine-and-freshwater-ecotypes
#19
S M Rastorguev, A V Nedoluzhko, N M Gruzdeva, E S Boulygina, S V Tsygankova, D Y Oshchepkov, A M Mazur, E B Prokhortchouk, K G Skryabin
Three-spine stickleback (Gasterosteus aculeatus) is a well-known model organism that is routinely used to explore microevolution processes and speciation, and the number of studies related to this fish has been growing recently. The main reason for the increased interest is the processes of freshwater adaptation taking place in natural populations of this species. Freshwater three-spined stickleback populations form when marine water three-spined sticklebacks fish start spending their entire lifecycle in freshwater lakes and streams...
January 2018: Acta Naturae
https://www.readbyqxmd.com/read/29707250/the-innovation-scorecard-for-continuous-improvement-applied-to-translational-science
#20
Joseph A Kotarba, Kevin Wooten
Introduction: This paper reports on the baseline stage of a qualitative evaluation of the application of the Innovative Scorecard (ISC) to the Clinical and Translational Science Award (CTSA) at the University of Texas Medical Branch (UTMB) at Galveston. The ISC is adopted from the established Balanced Scorecard system for strategic planning and performance management. In formulating the evaluation, we focused on the organizational identity literature. Methods: The initial evaluation consisted of a series of semi-structured interviews with 22 participants of the ISC Boot Camp conducted in July 2015...
October 2017: Journal of Clinical and Translational Science
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