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https://www.readbyqxmd.com/read/28077111/cumulative-exposure-to-shift-work-and-sickness-absence-associations-in-a-five-year-historic-cohort
#1
Alwin van Drongelen, Cécile R L Boot, Hynek Hlobil, Allard J van der Beek, Tjabe Smid
BACKGROUND: Exposure to shift work has been associated with negative health consequences, although the association between shift work and sickness absence remains unclear. The aim of this study is to investigate associations between cumulative exposure to shift work and sickness absence among ground staff employees of an airline company. METHODS: This study used data from the MORE (Monitoring Occupational Health Risks in Employees) cohort, which is a 5-year historic cohort...
January 11, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28075556/biosynthesis-of-the-methylthioxylose-capping-motif-of-lipoarabinomannan-in-mycobacterium-tuberculosis
#2
Shiva Kumar Angala, Michael R McNeil, Libin Shi, Maju Joe, Ha Pham, Sophie Zuberogoitia, Jerome Nigou, Claudia M Boot, Todd L Lowary, Martine Gilleron, Mary Jackson
Lipoarabinomannan (LAM) is a lipoglycan found in abundant quantities in the cell envelope of all mycobacteria. The non-reducing arabinan termini of LAM display species-specific structural micro-heterogeneity that impacts the biological activity of the entire molecule. Mycobacterium tuberculosis, for instance, produces mannoside caps made of one to three α(1→2)-Manp-linked residues that may be further substituted with an α(1→4)-linked methylthio-D-xylose (MTX) residue. While the biological functions and catalytic steps leading to the formation of the mannoside caps of M...
January 11, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28075055/argonaute-2-immunoprecipitation-revealed-lats1-as-a-novel-pro-apoptotic-target-of-mir-21-in-t-cells
#3
Nato Teteloshvili, Katarzyna Smigielska-Czepiel, Ye Yuan, Annika Seitz, Debora de Jong, Bea Rutgers, Pytrick Jellema, Roelof Jan van der Lei, Izabella Slezak-Prochazka, Elisabeth Brouwer, Annemieke M H Boots, Bart-Jan Kroesen, Anke van den Berg, Joost Kluiver
MicroRNA (miR)-21 is an important suppressor of T-cell apoptosis that is also overexpressed in many types of cancers. The exact mechanisms underlying the anti-apoptotic effects of miR-21 are not well understood. In this study, we used the Jurkat T-cell line as a model to identify apoptosis-associated miR-21 target genes. We showed that expression of miR-21 rapidly increases upon αCD3/αCD28 activation of Jurkat cells. Inhibition of miR-21 reduced cell growth which could be explained by an increase in apoptosis...
January 11, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28073545/a-validated-uplc-ms-ms-method-for-the-surveillance-of-ten-aquatic-biotoxins-in-european-brackish-and-freshwater-systems
#4
Brett Greer, Sara E McNamee, Bas Boots, Lucia Cimarelli, Delphine Guillebault, Karim Helmi, Stefania Marcheggiani, Stefan Panaiotov, Ulrich Breitenbach, Reyhan Akçaalan, Linda K Medlin, Katrin Kittler, Christopher T Elliott, Katrina Campbell
Over the past few decades, there has been an increased frequency and duration of cyanobacterial Harmful Algal Blooms (HABs) in freshwater systems globally. These can produce secondary metabolites called cyanotoxins, many of which are hepatotoxins, raising concerns about repeated exposure through ingestion of contaminated drinking water or food or through recreational activities such as bathing/swimming. An ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) multi-toxin method has been developed and validated for freshwater cyanotoxins; microcystins-LR, -YR, -RR, -LA, -LY and -LF, nodularin, cylindrospermopsin, anatoxin-a and the marine diatom toxin domoic acid...
May 2016: Harmful Algae
https://www.readbyqxmd.com/read/28069408/role-of-food-preoccupation-and-current-dieting-in-the-associations-of-parental-feeding-practices-to-emotional-eating-in-young-adults-a-moderated-mediation-study
#5
Natalie A Williams, Dipti A Dev, Maren Hankey, Kimberly Blitch
Parental feeding practices reflecting coercive control are related to children's later eating behaviors, but the mechanisms underlying these effects remain poorly understood. This study examined the relationships between recalled childhood experiences of parental pressure to eat and restriction and current food preoccupation, dieting, and emotional eating in a racially diverse sample of college students (N = 711). Results revealed that parental restriction, but not pressure to eat, was associated with more emotional eating (r = 0...
January 6, 2017: Appetite
https://www.readbyqxmd.com/read/28056885/working-conditions-and-public-health-risks-in-slaughterhouses-in-western-kenya
#6
Elizabeth Anne Jessie Cook, William Anson de Glanville, Lian Francesca Thomas, Samuel Kariuki, Barend Mark de Clare Bronsvoort, Eric Maurice Fèvre
BACKGROUND: Inadequate facilities and hygiene at slaughterhouses can result in contamination of meat and occupational hazards to workers. The objectives of this study were to assess current conditions in slaughterhouses in western Kenya and the knowledge, and practices of the slaughterhouse workers toward hygiene and sanitation. METHODS: Between February and October 2012 all consenting slaughterhouses in the study area were recruited. A standardised questionnaire relating to facilities and practices in the slaughterhouse was administered to the foreperson at each site...
January 5, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28047265/tu-h-bra-05-a-system-design-for-integration-of-an-interior-mri-and-a-linear-accelerator
#7
W Mao, G Wang
PURPOSE: MRI is a highly desirable modality to guide radiation therapy but it is difficult to combine a conventional MRI scanner directly with a linear accelerator (linac). An interior MRI (iMRI) concept has been proposed to acquire MRI images within a small field of view only covering targets and immediate surrounding tissues. The objective of this project is to design an interior MRI system to work with a linac using a magnet to provide a field around 0.2T in a cube of 20cm per side, and perform image reconstruction with a slightly inhomogeneous static magnetic fields...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043961/stakeholder-engagement-in-diabetes-self-management-patient-preference-for-peer-support-and-other-insights
#8
Bethany M Kwan, Bonnie Jortberg, Meredith K Warman, Ilima Kane, Robyn Wearner, Romona Koren, Thomas Carrigan, Vincent Martinez, Donald E Nease
BACKGROUND: Self-management support (SMS) for patients with diabetes can improve adherence to treatment, mitigate disease-related distress, and improve health outcomes. Translating this evidence into real-world practice is needed, as it is not clear which SMS models are acceptable to patients, and feasible and sustainable for primary care practices. OBJECTIVE: To use the Boot Camp Translation (BCT) method to engage patient, practice, community resource and research stakeholders in translation of evidence about SMS and diabetes distress into mutually acceptable care models and to inform patient-centred outcomes research (PCOR)...
January 1, 2017: Family Practice
https://www.readbyqxmd.com/read/28039794/the-costs-or-benefits-associated-with-attended-objects-do-little-to-influence-inattentional-blindness
#9
Cary R Stothart, Timothy J Wright, Daniel J Simons, Walter R Boot
We sometimes fail to notice unexpected objects or events when our attention is directed elsewhere, a phenomenon called inattentional blindness. We explored whether unexpected objects that shared the color of consequential objects would be noticed more often. In three pre-registered experiments, participants played a custom video game in which they avoided both low- and high-cost missiles (Experiment 1 and 2) or tried to hit rewarding missiles while avoiding costly ones (Experiment 3). After participants had played the game for about 8min, an unexpected object moved across the screen...
December 28, 2016: Acta Psychologica
https://www.readbyqxmd.com/read/28035987/tumor-line-1-methylation-level-in-association-with-survival-of-patients-with-stage-ii-colon-cancer
#10
Marloes Swets, Anniek Zaalberg, Arnoud Boot, Tom van Wezel, Martine A Frouws, Esther Bastiaannet, Hans Gelderblom, Cornelis J H van de Velde, Peter J K Kuppen
Genome-wide DNA hypomethylation is associated with a worse prognosis in early-stage colorectal cancer. To measure genome-wide DNA methylation levels, long interspersed nucleotide element (LINE-1) repeats are used as a surrogate marker. Cohort studies on the clinical impact of genome-wide DNA methylation level in patients with only early-stage colon cancer, are currently lacking. This study aimed to investigate the prognostic value of LINE-1 methylation in a stage II colon cancer cohort (n = 164). Manual needle microdissection of tumor areas was performed on formalin-fixed paraffin-embedded tumor tissue sections followed by DNA extraction...
December 27, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28025010/the-impact-of-resource-quality-on-the-evolution-of-virulence-in-spatially-heterogeneous-environments
#11
Min Su, Mike Boots
Understanding the drivers of parasite evolution and in particular disease virulence remains a major focus of evolutionary theory. Here, we examine the role of resource quality and in particular spatial environmental heterogeneity in the distribution of these resources on the evolution of virulence. There may be direct effects of resources on host susceptibility and pathogenicity alongside effects on reproduction that indirectly impact host-parasite population dynamics. Therefore, we assume that high resource quality may lead to both increased host reproduction and/or increased disease resistance...
December 23, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28018373/non-destructive-assessment-of-plant-nitrogen-parameters-using-leaf-chlorophyll-measurements-in-rice
#12
Syed Tahir Ata-Ul-Karim, Qiang Cao, Yan Zhu, Liang Tang, Muhammad Ishaq Asif Rehmani, Weixing Cao
Non-destructive assessment of plant nitrogen (N) status is essential for efficient crop production and N management in intensive rice (Oryza sativa L.) cropping systems. Chlorophyll meter (SPAD-502) has been widely used as a rapid, non-destructive and cost-effective diagnostic tool for in-season assessment of crop N status. The present study was intended to establish the quantitative relationships between chlorophyll meters readings, plant N concentration (PNC), N nutrition index (NNI), accumulated N deficit (AND), and N requirement (NR), as well as to compare the stability of these relationships at different vegetative growth stages in Japonica and Indica rice cultivars...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28018353/embracing-complexity-beyond-systems-medicine-a-new-approach-to-chronic-immune-disorders
#13
Anje A Te Velde, Tjitske Bezema, Antoine H C van Kampen, Aletta D Kraneveld, Bert A 't Hart, Henriët van Middendorp, Erik C Hack, Joris M van Montfrans, Clara Belzer, Lilian Jans-Beken, Raymond H Pieters, Karen Knipping, Machteld Huber, Annemieke M H Boots, Johan Garssen, Tim R Radstake, Andrea W M Evers, Berent J Prakken, Irma Joosten
In order to combat chronic immune disorders (CIDs), it is an absolute necessity to understand the bigger picture, one that goes beyond insights at a one-disease, molecular, cellular, and static level. To unravel this bigger picture we advocate an integral, cross-disciplinary approach capable of embracing the complexity of the field. This paper discusses the current knowledge on common pathways in CIDs including general psychosocial and lifestyle factors associated with immune functioning. We demonstrate the lack of more in-depth psychosocial and lifestyle factors in current research cohorts and most importantly the need for an all-encompassing analysis of these factors...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/28009599/a-national-curriculum-of-fundamental-skills-for-plastic-surgery-residency-report-of-the-inaugural-acaps-boot-camp
#14
Edward H Davidson, Jenny C Barker, Francesco M Egro, Alexandra Krajewski, Jeffrey E Janis, Vu T Nguyen
BACKGROUND: The Inaugural American Council of Academic Plastic Surgeons Plastic Surgery Boot Camp program was developed in response to ongoing changes in graduate medical education. The Boot Camp is a hands-on, practicum-based, 3-day course to introduce core concepts in plastic surgery for new plastic surgery residents (in both integrated and independent tracks). METHODS: The course was held in Pittsburgh in July to August 2015. There were 43 attendees (35 integrated/8 independent) representing 22 residency programs across 15 states...
December 22, 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28005003/pleasant-preventing-and-lessening-exacerbations-of-asthma-in-school-age-children-associated-with-a-new-term-a-cluster-randomised-controlled-trial-and-economic-evaluation
#15
Steven A Julious, Michelle J Horspool, Sarah Davis, Mike Bradburn, Paul Norman, Neil Shephard, Cindy L Cooper, W Henry Smithson, Jonathan Boote, Heather Elphick, Amanda Loban, Matthew Franklin, Wei Sun Kua, Robin May, Jennifer Campbell, Rachael Williams, Saleema Rex, Oscar Bortolami
BACKGROUND: Asthma episodes and deaths are known to be seasonal. A number of reports have shown peaks in asthma episodes in school-aged children associated with the return to school following the summer vacation. A fall in prescription collection in the month of August has been observed, and was associated with an increase in the number of unscheduled contacts after the return to school in September. OBJECTIVE: The primary objective of the study was to assess whether or not a NHS-delivered public health intervention reduces the September peak in unscheduled medical contacts...
December 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28000364/a-specific-activity-based-probe-to-monitor-family-gh59-galactosylceramidase-the-enzyme-deficient-in-krabbe-disease
#16
André Ra Marques, Lianne I Willems, Daniela Herrera Moro, Bogdan I Florea, Saskia Scheij, Roelof Ottenhoff, Cindy van Roomen, Marri Verhoek, Jessica K Nelson, Wouter W Kallemeijn, Anna Biela-Banas, Olivier R Martin, M Begoña Cachón-González, Nee Na Kim, Timothy M Cox, Rolf G Boot, Herman S Overkleeft, Johannes M F G Aerts
Galactosylceramidase (GALC) is the lysosomal β-galactosidase responsible for the hydrolysis of galactosylceramide. Inherited deficiency in GALC causes Krabbe disease, a devastating neurological disorder characterized by accumulation of galactosylceramide and its deacylated counterpart, the toxic sphingoid base galactosylsphingosine (psychosine). We report the design and application of a fluorescently tagged activity-based probe (ABP) for the sensitive and specific labeling of active GALC molecules from various species...
December 20, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27999604/the-construction-of-unsmooth-pulse-images-in-traditional-chinese-medicine-based-on-wave-intensity-technology
#17
Jie-Wei Luo, Si-Wei Guo, Shuang-Shuang Cao, Ning Lin, Zhen-Sheng Ye, Shi-Chao Wei, Xing-Yu Zheng, Miao-Miao Guo, Xiao-Rong Meng, Fang-Meng Huang
Unsmooth pulse is one of the most important pulses in TCM diagnostics. We constructed the wave intensity (WI) images of unsmooth pulse based on the pressure wave (P), flow velocity wave (U), and WI [(dP/dt)(dU/dt)] by ALOKA Prosound α 10 Color Doppler. The characteristic of Cunkou normal pulse could be summarized as follows: compared to Renying pulse, its W1 amplitude is smaller and NA wave is more obvious, while the W2 wave is indistinct or even invisible, and the R-1st is longer than that of Renying pulse...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27998218/prevalence-and-risk-factors-of-early-endocrine-disorders-in-childhood-brain-tumor-survivors-a-nationwide-multicenter-study
#18
Sarah C Clement, Antoinette Y N Schouten-van Meeteren, Annemieke M Boot, Hedy L Claahsen-van der Grinten, Bernd Granzen, K Sen Han, Geert O Janssens, Erna M Michiels, A S Paul van Trotsenburg, W Peter Vandertop, Dannis G van Vuurden, Leontien C M Kremer, Hubert N Caron, Hanneke M van Santen
Purpose To evaluate the prevalence of, and risk factors for, early endocrine disorders in childhood brain tumor survivors (CBTS). Patients and Methods This nationwide study cohort consisted of 718 CBTS who were diagnosed between 2002 and 2012, and who survived ≥ 2 years after diagnosis. Patients with craniopharyngeoma or a pituitary gland tumor were excluded. Results of all endocrine investigations, which were performed at diagnosis and during follow-up, were collected from patient charts. Multivariable logistic regression was used to study associations between demographic and tumor- and treatment-related variables and the prevalence of early endocrine disorders...
December 20, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27989343/early-protected-weightbearing-after-ankle-fractures-in-patients-with-diabetes-mellitus
#19
Irina Bazarov, Ruth A Peace, Pieter M Lagaay, Sandeep B Patel, Liisa L Lyon, John M Schuberth
The traditional protocol for treatment after ankle fracture in the diabetic patient involves a period of prolonged non-weightbearing to reduce the incidence of complications. The goal of the present study was to identify the risk factors and complications associated with early protected weightbearing after closed ankle fractures in patients with diabetes. The data from 73 diabetic patients with operatively and nonoperatively treated ankle fractures were retrospectively reviewed. All patients were allowed to begin protected weightbearing in a cast or removable boot at 2 weeks after the index injury or surgery...
January 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/27987018/-osteosynthesis-of-distal-fibular-fractures-with-illuminoss-video-article
#20
M Zyskowski, M Crönlein, E Heidt, P Biberthaler, C Kirchhoff
OBJECTIVE: The aim was minimally invasive osteosynthesis of a distal fibular fracture under the premises of poor soft tissue conditions and existing chronic comorbidities to enable rapid recovery and to reduce soft tissue stress in order to avoid postoperative infections and achieve early weight bearing. INDICATIONS: This involved a distal fibula fracture, classified as 44 B1.1, B1.2, B1.3 according to the working group for osteosynthesis (AO) or a B fracture after Danis and Weber with indications for surgery (cortical disruption and shaft offset > 5 mm), age > 65 years, poor soft tissue conditions and a Charlson score ≥ 1...
December 16, 2016: Der Unfallchirurg
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