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https://www.readbyqxmd.com/read/28937763/hybrid-cis-trans-tetra-arylethenes-with-switchable-aie-and-reversible-photochromism-in-the-solution-pmma-film-solid-powder-and-single-crystal
#1
Qianfu Luo, Fei Cao, Chaochao Xiong, Qingyu Dou, Da-Hui Qu
How to efficiently design and synthesize multifunctional molecules is particularly challenging. Here we devote to constructing a kind of simple structures with composite functionalities through straightforward preparation. Starting from common commercially available materials, the titled cis/ tans-tetraarylethenes can be conveniently obtained by one-pot under mild conditions. The different configurations were confirmed by 1H NMR and single crystal data analysis. The trans-tetraarylethenes could be converted into cis-forms not only by photo-irradiation but also by microwave irradiation, which provided us a new choice for isomeric conversion, especially for which sensitive to light...
September 22, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28936422/forgotten-excluded-or-included-students-with-disabilities-a-case-study-at-the-university-of-mauritius
#2
Sameerchand Pudaruth, Rajendra P Gunputh, Upasana G Singh
BACKGROUND: Students with disabilities in the tertiary education sector are more than a just a phenomenon, they are a reality. In general, little attention is devoted to their needs despite the fact that they need more care and attention. OBJECTIVES: This paper, through a case study at the University of Mauritius, sought to answer some pertinent questions regarding students with disabilities. Does the University of Mauritius have sufficient facilities to support these students? Are students aware of existing facilities? What additional structures need to be put in place so that students with any form of disability are neither victimised, nor their education undermined? Are there any local laws about students with disabilities in higher education? METHOD: To answer these questions and others, an online questionnaire was sent to 500 students and the responses were then analysed and discussed...
2017: Afr J Disabil
https://www.readbyqxmd.com/read/28934695/type-1-diabetes-and-viral-infections-what-is-the-relationship
#3
REVIEW
Nicola Principi, Maria Giulia Berioli, Sonia Bianchini, Susanna Esposito
Type 1 diabetes (T1D) is the most common chronic metabolic disorder in children. Epigenetic and environmental factors capable of altering the penetrance of major susceptibility genes or capable of increasing the penetrance of low-risk genes are currently thought to play a role in triggering autoimmunity and T1D development. This paper discusses the current knowledge of the role of viruses in T1D. Most studies that have evaluated the potential association between viral infections and T1D have indicated that it is highly likely that some of these infectious agents play a role in T1D development...
September 8, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28934133/understanding-the-mechanism-of-translocation-of-adenylate-cyclase-toxin-across-biological-membranes
#4
REVIEW
Helena Ostolaza, César Martín, David González-Bullón, Kepa B Uribe, Asier Etxaniz
Adenylate cyclase toxin (ACT) is one of the principal virulence factors secreted by the whooping cough causative bacterium Bordetella pertussis, and it has a critical role in colonization of the respiratory tract and establishment of the disease. ACT targets phagocytes via binding to the CD11b/CD18 integrin and delivers its N-terminal adenylate cyclase (AC) domain directly to the cell cytosol, where it catalyzes unregulated conversion of cytosolic ATP into cAMP upon activation by binding to cellular calmodulin...
September 21, 2017: Toxins
https://www.readbyqxmd.com/read/28933839/flexible-and-comprehensive-implementation-of-md-pmm-approach-in-a-general-and-robust-code
#5
Oliver Carrillo-Parramon, Sara Del Galdo, Massimiliano Aschi, Giordano Mancini, Andrea Amadei, Vincenzo Barone
The Perturbed Matrix Method (PMM) approach to be used in combination with Molecular Dynamics (MD) trajectories (MD-PMM) has been recoded from scratch, improved in several aspects, and implemented in the Gaussian suite of programs for allowing user friendly and yet flexible tool to estimate quantum chemistry observables in complex systems in condensed phases. Particular attention has been devoted to a description of rigid and flexible quantum centers together with powerful essential dynamics and clustering approaches...
September 21, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28933724/an-automatic-multi-target-independent-analysis-framework-for-non-planar-infrared-visible-registration
#6
Xinglong Sun, Tingfa Xu, Jizhou Zhang, Zishu Zhao, Yuankun Li
In this paper, we propose a novel automatic multi-target registration framework for non-planar infrared-visible videos. Previous approaches usually analyzed multiple targets together and then estimated a global homography for the whole scene, however, these cannot achieve precise multi-target registration when the scenes are non-planar. Our framework is devoted to solving the problem using feature matching and multi-target tracking. The key idea is to analyze and register each target independently. We present a fast and robust feature matching strategy, where only the features on the corresponding foreground pairs are matched...
July 26, 2017: Sensors
https://www.readbyqxmd.com/read/28932481/the-7-aza-norbornane-nucleus-of-epibatidine-7-aza-bicyclo-2-2-1-heptan-7-ium-chloride
#7
Sergey N Britvin, Andrey M Rumyantsev
7-Aza-bicyclo-[2.2.1]heptane (7-aza-norbornane) is a bridged heterocyclic nucleus found in epibatidine, the alkaloid isolated from the skin of the tropical poison frog Epipedobates tricolor. Since epibatidine is known as one of the most potent acetyl-choline nicotinic receptor agonists, a plethora of literature has been devoted to this alkaloid. However, there are no structural data on the unsubstituted 7-aza-norbornane, the parent bicyclic ring of epibatidine and its derivatives. We herein present the structural characterization of the 7-aza-bicyclo-[2...
September 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28932180/hardware-efficient-on-line-learning-through-pipelined-truncated-error-backpropagation-in-binary-state-networks
#8
Hesham Mostafa, Bruno Pedroni, Sadique Sheik, Gert Cauwenberghs
Artificial neural networks (ANNs) trained using backpropagation are powerful learning architectures that have achieved state-of-the-art performance in various benchmarks. Significant effort has been devoted to developing custom silicon devices to accelerate inference in ANNs. Accelerating the training phase, however, has attracted relatively little attention. In this paper, we describe a hardware-efficient on-line learning technique for feedforward multi-layer ANNs that is based on pipelined backpropagation...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28931871/filtering-effect-of-temporal-niche-fluctuation-and-amplitude-of-environmental-variations-on-the-trait-related-flowering-patterns-lesson-from-sub-mediterranean-grasslands
#9
Andrea Catorci, Karina Piermarteri, Károly Penksza, Judit Házi, Federico Maria Tardella
Timing of flowering is a critical component of community assembly, but how plant traits respond to heterogeneity of resources has been identified mostly through observations of spatial variations. Thus, we performed a trait-based phenological study in sub-Mediterranean grasslands to assess the importance of temporal variation of resources in the species assemblage processes. We found that early flowering species have traits allowing for slow resource acquisition and storage but rapid growth rate. Instead, mid- and late-flowering species exhibited sets of strategies devoted to minimizing water loss by evapotranspiration or aimed at maximizing the species' competitive ability, thanks to slow growth rate and more efficient resource acquisition, conservation and use...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28928805/importance-of-tuberin-in-carcinogenesis
#10
Mingwei Jin, Qi An, Lei Wang
The cell cycle is a dynamic process with multiple phases regulating cell growth. The proper regulation is essential for avoiding errors and activation of cell death. Tumour suppressor proteins, including tuberin, are crucial in coordinating adequate cell growth and properly timed cell division. So, the present review article is focused on the latest aspects of the tuberin in the process of carcinogenesis. The PubMed was the main database used for the collection of latest data relating to multiple aspects of tuberin especially in context of cancer...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927980/william-ladd-before-the-halifax-explosion
#11
REVIEW
Don K Nakayama
Legend holds that treating the hundreds of children injured in the Halifax explosion of December 6, 1917, compelled Dr. William E. Ladd (1880-1967) to dedicate his career to the surgical care of infants and children. However, he had made the commitment to be a pediatric surgeon several years before when he joined the voluntary staff of the Children's Hospital of Boston in 1910. In the years before Halifax, he was among the vanguard of American surgeons who brought the mortality of intussusception to 45% from 90%, and of pyloric stenosis to 15% from 60%...
September 5, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28927575/inequity-in-healthcare-use-among-older-people-after-2008-the-case-of-southern-european-countries
#12
Lara Patrício Tavares, Francesca Zantomio
Despite the sizeable cuts in public healthcare spending, which were part of the austerity measures recently undertaken in Southern European countries, little attention has been devoted to monitoring its distributional consequences in terms of healthcare use. This study aims at measuring socioeconomic inequities in primary and secondary healthcare use experienced some time after the crisis onset in Italy, Spain and Portugal. The analysis, based on data drawn from the Survey of Health, Ageing and Retirement in Europe (SHARE), focuses on older people, who generally face significantly higher healthcare needs, and whose health appeared to have worsened in the aftermath of the crisis...
September 16, 2017: Health Policy
https://www.readbyqxmd.com/read/28925595/determination-of-crassphage-in-water-samples-and-applicability-for-tracking-human-faecal-pollution
#13
Cristina García-Aljaro, Elisenda Ballesté, Maite Muniesa, Juan Jofre
In recent decades, considerable effort has been devoted to finding microbial source-tracking (MST) markers that are suitable to assess the health risks of faecally polluted waters, with no universal marker reported so far. In this study, the abundance and prevalence of a crAssphage-derived DNA marker in wastewaters of human and animal origins were studied by a new qPCR assay with the ultimate aim of assessing its potential as an MST marker. crAssphage showed up to 10(6) GC/ml in the sewage samples of human origin, in both the total DNA and the viral DNA fraction...
September 19, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28923209/angiogenesis-inhibition-in-the-second-line-treatment-of-metastatic-colorectal-cancer-a-systematic-review-and-pooled-analysis
#14
REVIEW
Ralph Chebib, Loic Verlingue, Nathalie Cozic, Matthieu Faron, Pascal Burtin, Valérie Boige, Antoine Hollebecque, David Malka
The last two decades have seen intensive efforts devoted to the development of compounds that target angiogenesis for the treatment of metastatic colorectal cancer (mCRC). In this review, we describe supporting evidence and ongoing development of angiogenesis inhibitors in the second-line treatment of mCRC, and summarize relevant randomized trials to help therapeutic decision-making in daily practice.
April 2017: Seminars in Oncology
https://www.readbyqxmd.com/read/28923161/comparing-the-cognitive-process-of-circular-causality-in-two-patients-with-strokes-through-qualitative-analysis
#15
Seyed Alireza Derakhshanrad, Emily Piven, Bahareh Zeynalzadeh Ghoochani
Walter J. Freeman pioneered the neurodynamic model of brain activity when he described the brain dynamics for cognitive information transfer as the process of circular causality at intention, meaning, and perception (IMP) levels. This view contributed substantially to establishment of the Intention, Meaning, and Perception Model of Neuro-occupation in occupational therapy. As described by the model, IMP levels are three components of the brain dynamics system, with nonlinear connections that enable cognitive function to be processed in a circular causality fashion, known as Cognitive Process of Circular Causality (CPCC)...
October 2017: Nonlinear Dynamics, Psychology, and Life Sciences
https://www.readbyqxmd.com/read/28922234/consensus-statement-by-the-congenital-cardiac-anesthesia-society-milestones-for-the-pediatric-cardiac-anesthesia-fellowship
#16
Viviane G Nasr, Nina A Guzzetta, Wanda C Miller-Hance, Mark Twite, Gregory J Latham, Luis Zabala, Susan C Nicolson, Emad B Mossad, James A DiNardo
Pediatric cardiac anesthesiology has evolved as a subspecialty of both pediatric and cardiac anesthesiology and is devoted to caring for individuals with congenital heart disease ranging in age from neonates to adults. Training in pediatric cardiac anesthesia is a second-year fellowship with variability in both training duration and content and is not accredited by the Accreditation Council on Graduate Medical Education. Consequently, in this article and based on the Accreditation Council on Graduate Medical Education Milestones Model, an expert panel of the Congenital Cardiac Anesthesia Society, a section of the Society of Pediatric Anesthesiology, defines 18 milestones as competency-based developmental outcomes for training in the pediatric cardiac anesthesia fellowship...
September 14, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28921784/the-evolution-of-gonad-expenditure-and-gonadosomatic-index-gsi-in-male-and-female-broadcast-spawning-invertebrates
#17
Geoff A Parker, Steven A Ramm, Jussi Lehtonen, Jonathan M Henshaw
Sedentary broadcast-spawning marine invertebrates, which release both eggs and sperm into the water for fertilization, are of special interest for sexual selection studies. They provide unique insight into the early stages of the evolutionary succession leading to the often-intense operation of both pre- and post-mating sexual selection in mobile gonochorists. Since they are sessile or only weakly mobile, adults can interact only to a limited extent with other adults and with their own fertilized offspring...
September 18, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/28921647/pharmacogenomics-implementation-at-the-national-institutes-of-health-clinical-center
#18
Tristan M Sissung, Jon W McKeeby, Jharana Patel, Juan J Lertora, Parag Kumar, Willy A Flegel, Sharon D Adams, Ellen J Eckes, Frank Mickey, Teri M Plona, Stephanie D Mellot, Ryan N Baugher, Xiaolin Wu, Daniel R Soppet, Mary E Barcus, Vivekananda Datta, Kristen M Pike, Gary DiPatrizio, William D Figg, Barry R Goldspiel
The National Institutes of Health Clinical Center (NIH CC) is the largest hospital in the United States devoted entirely to clinical research, with a highly diverse spectrum of patients. Patient safety and clinical quality are major goals of the hospital, and therapy is often complicated by multiple cotherapies and comorbidities. To this end, we implemented a pharmacogenomics program in 2 phases. In the first phase, we implemented genotyping for HLA-A and HLA-B gene variations with clinical decision support (CDS) for abacavir, carbamazepine, and allopurinol...
October 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28921584/we-didn-t-say-that-challenges-in-the-public-dissemination-of-a-research-finding-with-controversial-implications
#19
Zachary P Neal, Jennifer Watling Neal
In the March 2014 issue of American Journal of Community Psychology, we published an article that examined the tension between two core values in the field of community psychology: promoting contextual conditions that foster respect for diversity and promoting contextual conditions that foster sense of community. We concluded that processes of social network formation could help explain why diversity and sense of community are seemingly incompatible goals. The study's findings initially disseminated through the usual academic channels, and later through mainstream media outlets...
September 18, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/28920185/motivational-wheel-running-reverses-cueing-behavioural-inflexibility-in-rodents
#20
Taylor Chomiak, Andrew R Brown, G Campbell Teskey, Bin Hu
Behavioural inflexibility and associated atypical learning behaviours are common clinical manifestations of the autism spectrum disorder (ASD) phenotype. Despite advances in our understanding of ASD, little research has been devoted to experimental interventions that might help to circumvent behavioural inflexibility in ASD. The current paper suggests that motivational locomotion in the form of wheel running can reduce behavioural inflexibility and learning impairments in an ASD rat model, and discusses how the strategy of reward-coupled locomotor activity may lead to clinical interventions for children with ASD...
September 18, 2017: Journal of Neural Transmission
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