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https://www.readbyqxmd.com/read/28648234/in-search-of-the-golden-skill
#1
John W Krakauer
Athletes devote their lives to practicing their chosen sport so as to attain the highest level of skilled performance. A perennial question is why are some athletes better than others? Most debates on this issue reduce to genetics (natural abilities) vs differences in accumulated deliberative practice. In contrast, the target article under discussion here reports on a study that identified psychosocial factors (obsessiveness, ruthlessness) and early life experiences (trauma or loss) that distinguished those athletes at the Olympics and World Championships that medaled over those that did not...
2017: Progress in Brain Research
https://www.readbyqxmd.com/read/28648192/-contemporary-behavioural-addictions-an-overview-and-the-nursing-position
#2
Philippe Nuss
Behavioural addiction is characterised by thoughts focused on a particular activity and its repetition, with a significant amount of time devoted to this activity at the expense of others. The nurse must adapt to these addicts by treating them as individuals without judging them and by trying to understand how they have tried, through this behaviour, to resolve their issues. The challenge is to reposition the body at the heart of the nursing relationship.
June 2017: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/28647495/ecological-monitoring-in-a-discrete-time-prey-predator-model
#3
M Gámez, I López, C Rodríguez, Z Varga, J Garay
The paper is aimed at the methodological development of ecological monitoring in discrete-time dynamic models. In earlier papers, in the framework of continuous-time models, we have shown how a systems-theoretical methodology can be applied to the monitoring of the state process of a system of interacting populations, also estimating certain abiotic environmental changes such as pollution, climatic or seasonal changes. In practice, however, there may be good reasons to use discrete-time models. (For instance, there may be discrete cycles in the development of the populations, or observations can be made only at discrete time steps...
June 21, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28647491/emerging-pharmacological-approaches-to-promote-neurogenesis-from-endogenous-glial-cells
#4
REVIEW
Enrica Boda, Giulia Nato, Annalisa Buffo
Neurodegenerative disorders are emerging as leading contributors to the global disease burden. While some drug-based approaches have been designed to limit or prevent neuronal loss following acute damage or chronic neurodegeneration, regeneration of functional neurons in the adult Central Nervous System (CNS)still remains an unmet need. In this context, theexploitation of endogenous cellsources has recently gained an unprecedented attention, thanks to the demonstration that, in some CNS regions or under specific circumstances, glial cells can activate spontaneous neurogenesis or can be instructed to produceneurons in the adult mammalian CNS parenchyma...
June 21, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28642259/staff-experiences-and-perceptions-of-working-with-in-patients-who-are-suicidal-qualitative-analysis
#5
Yvonne Awenat, Sarah Peters, Emma Shaw-Nunez, Patricia Gooding, Daniel Pratt, Gillian Haddock
BackgroundSuicidal behaviour is frequent in psychiatric in-patients and much staff time and resources are devoted to assessing and managing suicide risk. However, little is known about staff experiences of working with in-patients who are suicidal.AimsTo investigate staff experiences of working with in-patients who are suicidal.MethodQualitative study guided by thematic analysis of semi-structured interviews with mental health staff with experience of psychiatric in-patient care.ResultsTwenty staff participated...
June 22, 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28641461/the-impact-of-data-errors-on-the-outcome-of-randomized-clinical-trials
#6
Marc Buyse, Pierre Squifflet, Elisabeth Coart, Emmanuel Quinaux, Cornelis Ja Punt, Everardo D Saad
Background/aims Considerable human and financial resources are typically spent to ensure that data collected for clinical trials are free from errors. We investigated the impact of random and systematic errors on the outcome of randomized clinical trials. Methods We used individual patient data relating to response endpoints of interest in two published randomized clinical trials, one in ophthalmology and one in oncology. These randomized clinical trials enrolled 1186 patients with age-related macular degeneration and 736 patients with metastatic colorectal cancer...
June 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/28639559/pressure-induced-superconductivity-in-cras-and-mnp
#7
Jinguang Cheng, Jian Lin Luo
Transition-metal monopnictides, CrAs and MnP, have been studied over fifty years ago due to the presence of interesting magnetic properties: CrAs forms a double-helical magnetic structure below TN ≈ 270 K accompanied with a strong first-order structural transition, while MnP first undergoes a ferromagnetic transition at TC ≈ 290 K and then adopts a similar double-helical order below Ts ≈ 50 K. Both compounds are correlated metals and exhibit distinct anomalies at these characteristic magnetic transitions...
June 22, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28639111/a-lifetime-s-adventure-in-extracellular-k-regulation-the-scottish-connection
#8
Angus M Brown
In a career that has spanned 45 years and shows no signs of slowing down, Dr Bruce Ransom has devoted considerable time and energy to studying regulation of interstitial K(+). When Bruce commenced his studies in 1969 virtually nothing was known of the functions of glial cells, but Bruce's research contributed to the physiological assignation of function to mammalian astrocytes, namely interstitial K(+) buffering. The experiments that I describe in this review concern the response of the membrane potential (Em) of in vivo cat cortical astrocytes to changes in [K(+)]o, an experimental manoeuvre that was achieved in two different ways...
June 21, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28638405/a-combined-one-class-svm-and-template-matching-approach-for-user-aided-human-fall-detection-by-means-of-floor-acoustic-features
#9
Diego Droghini, Daniele Ferretti, Emanuele Principi, Stefano Squartini, Francesco Piazza
The primary cause of injury-related death for the elders is represented by falls. The scientific community devoted them particular attention, since injuries can be limited by an early detection of the event. The solution proposed in this paper is based on a combined One-Class SVM (OCSVM) and template-matching classifier that discriminate human falls from nonfalls in a semisupervised framework. Acoustic signals are captured by means of a Floor Acoustic Sensor; then Mel-Frequency Cepstral Coefficients and Gaussian Mean Supervectors (GMSs) are extracted for the fall/nonfall discrimination...
2017: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/28638041/-the-presumption-of-mental-health-is-it-really-proved
#10
S N Shishkov, N V Skibina
The article is devoted to one of the most complicated and peculiar problems of modern psychiatry - the presumption of mental health. Its originality is seen in the fact that practically all speaking and writing about it noted the importance of this principle for the protection of rights and legal interests of citizens, failing into the field of psychiatry. However, expressing this opinion, doctors and lawyers offer very few arguments in support of this view. Traditional arguments in favor of the presumption of mental health, scattered and unsystematic, prove to be absolutely insolvent...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28637787/biophysics-and-biofluiddynamics-of-primary-cilia-evidence-for-and-against-the-flow-sensing-function
#11
Subhra Nag, Andrew Resnick
Primary cilia have been called "the forgotten organelle" for over 20 years. As cilia now have their own Journal and several books devoted to their study, perhaps it's time to reconsider the moniker "forgotten organelle". In fact, during the drafting of this review, 12 relevant publications have been issued- we therefore apologize in advance for any relevant work we inadvertently omitted. What purpose is yet another ciliary review? The primary goal of this review is to specifically examine the evidence for and against the hypothesized flow-sensing function of primary cilia expressed by differentiated epithelia within a kidney tubule, bringing together differing disciplines and their respective conceptual and experimental approaches...
June 21, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28636924/epithelial-folding-driven-by-apical-or-basal-lateral-modulation-geometric-features-mechanical-inference-and-boundary-effects
#12
Fu-Lai Wen, Yu-Chiun Wang, Tatsuo Shibata
During embryonic development, epithelial sheets fold into complex structures required for tissue and organ functions. Although substantial efforts have been devoted to identifying molecular mechanisms underlying epithelial folding, far less is understood about how forces deform individual cells to sculpt the overall sheet morphology. Here we describe a simple and general theoretical model for the autonomous folding of monolayered epithelial sheets. We show that active modulation of intracellular mechanics along the basal-lateral as well as the apical surfaces is capable of inducing fold formation in the absence of buckling instability...
June 20, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28636644/longitudinal-changes-in-physical-activity-sedentary-behavior-and-body-mass-index-in-adolescence-migrations-towards-different-weight-cluster
#13
José Devís-Devís, Jorge Lizandra, Alexandra Valencia-Peris, Esther Pérez-Gimeno, Xavier García-Massò, Carmen Peiró-Velert
This study examined longitudinal changes in physical activity, sedentary behavior and body mass index in adolescents, specifically their migrations towards a different weight cluster. A cohort of 755 adolescents participated in a three-year study. A clustering Self-Organized Maps Analysis was performed to visualize changes in subjects' characteristics between the first and second assessment, and how adolescents were grouped. Also a classification tree was used to identify the behavioral characteristics of the groups that changed their weight cluster...
2017: PloS One
https://www.readbyqxmd.com/read/28635974/conceptual-issues-surrounding-quality-of-life-in-oncology-nursing
#14
Marie Flannery
Quality of life (QOL) is a critical, prevalent, and enduring concept in oncology nursing research and practice. QOL is a paramount issue in the consideration of treatment, goal planning, and decision making for individuals with cancer, their families, and their care providers. Journals, well-developed valid and reliable instruments, and multiple conceptual models and frameworks are devoted to QOL. This column will review two broad conceptual aspects to consider in relation to QOL. First, conceptual considerations will be discussed for the definition and measurement of QOL...
May 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28635539/an-old-challenge-with-new-promises-a-systematic-review-on-comprehensive-geriatric-assessment-in-long-term-care-facilities
#15
Francesco Panza, Vincenzo Solfrizzi, Madia Lozupone, Maria Rosaria Barulli, Francesca D'Urso, Roberta Stallone, Vittorio Dibello, Alessia Noia, Cristina Di Dio, Antonio Daniele, Antonello Bellomo, Davide Seripa, Antonio Greco, Giancarlo Logroscino
Comprehensive geriatric assessment (CGA) is a multidimensional and multidisciplinary diagnostic process focused on determining the clinical profile, pathological risk, residual skills, short- and long-term prognosis, and the personalized therapeutic and care plan of the functionally compromised and frail older subjects. Previous evidence suggested that the effectiveness of CGA programs may be influenced by the settings where the CGA is performed [i.e., hospital, post-hospital discharge/ long-term care facilities (LTCF), or community/home] as well as the specific clinical conditions of older frail individuals...
June 21, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28633826/optimization-and-characterization-of-ultrasound-assisted-preparation-of-curcumin-loaded-solid-lipid-nanoparticles-application-of-central-composite-design-thermal-analysis-and-x-ray-diffraction-techniques
#16
Elham Sadati Behbahani, Mehrorang Ghaedi, Mohammadreza Abbaspour, Kobra Rostamizadeh
This study is devoted to preparation of novel solid lipid nanoparticles (SLNs) for the encapsulation of curcumin which is produced by micro-emulsion and ultrasonication using stearic acid and tripalmitin as solid lipids, tween80 and span80 as surfactants. The relation between particle size and entrapment efficiency of the produced SLNs was operated by central composite design (CCD) under response likes surface method (RSM). The variables including the ratio of lipids (X1), the ratio of surfactants (X2), drug/lipid ratio (X3), time of sonication (X4) and time of homogenization (X5)...
September 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28633106/selective-photocytotoxicity-of-anthrols-on-cancer-stem-like-cells-the-effect-of-quinone-methides-or-reactive-oxygen-species
#17
Lidija Uzelac, Đani Škalamera, Kata Mlinarić-Majerski, Nikola Basarić, Marijeta Kralj
Cancer stem cells (CSCs) are a subpopulation of cancer cells that share properties of embryonic stem cells like pluripotency and self-renewal and show increased resistance to chemo- and radiotherapy. Targeting CSC, rather than cancer cells in general, is a novel and promising strategy for cancer treatment. Novel therapeutic approaches, such as photodynamic therapy (PDT) have been investigated. A promising group of phototherapeutic agents are reactive intermediates - quinone methides (QMs). This study describes preparation of QM precursor, 2-hydroxy-3-hydroxymethylanthracene (2) and a detailed photochemical and photobiological investigation on similar anthracene derivatives 3 and 4...
June 3, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28632802/diversity-in-dermatology-a-society-devoted-to-skin-of-color
#18
Jacob Subash, Rechelle Tull, Amy McMichael
The US Census Bureau predicts that more than half of the country's population will identify as a race other than non-Hispanic white by the year 2044. Racial disparities also exist in the physician population where black individuals and Latinos are underrepresented. The Skin of Color Society (SOCS) was established to address the need for parity among dermatology patients with skin of color. The society provides educational support on dermatologic health related to skin of color and functions through committees that represent the multifaceted aspects of the organization...
May 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28632333/from-chemical-topology-to-molecular-machines-nobel-lecture
#19
REVIEW
Jean-Pierre Sauvage
To a large extent, the field of "molecular machines" started after several groups were able to prepare, reasonably easily, interlocking ring compounds (named catenanes for compounds consisting of interlocking rings and rotaxanes for rings threaded by molecular filaments or axes). Important families of molecular machines not belonging to the interlocking world were also designed, prepared, and studied but, for most of them, their elaboration was more recent than that of catenanes or rotaxanes. Since the creation of interlocking ring molecules is so important in relation to the molecular machinery area, we will start with this aspect of our work...
June 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28629637/direct-medical-cost-associated-with-colorectal-cancer-in-north-of-jordan
#20
Qais Alefan, Rana Malhees, Nizar Mhaidat
Colorectal cancer (CRC) is mainly characterized as the malignant and impaired growth of rectal cells in the intestinal region. Direct medical cost is related to resources, which are directly used in treating the patient, that mainly includes the cost of drugs, diagnostic, treatment, follow-up, rehabilitation, and hospital admission. The objective of this study is to estimate and analyze direct medical costs attributable to CRC in Jordan. A retrospective analysis of a cohort patients treated for CRC data has been performed to determine direct medical costs attributable to CRC in Jordan...
May 15, 2017: Current Problems in Cancer
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