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https://www.readbyqxmd.com/read/28449212/predictors-of-success-of-external-cephalic-version-and-cephalic-presentation-at-birth-among-1-253-women-with-non-cephalic-presentation-using-logistic-regression-and-classification-tree-analyses
#1
Eileen K Hutton, Julia C Simioni, Lehana Thabane
INTRODUCTION: Among women with a fetus in non-cephalic presentation, external cephalic version (ECV) has been shown to reduce the rate of breech presentation at birth and cesarean birth. Compared to ECV at term, beginning ECV prior to 37 weeks gestation decreases the number of infants in a non-cephalic presentation at birth. The purpose of this secondary analysis was to investigate factors associated with a successful ECV procedure and to present this in a clinically useful format. MATERIAL AND METHODS: Data were collected as part of the Early ECV Pilot and Early ECV2 Trials, which randomised 1,776 women with a fetus in breech presentation to either early ECV (34 to 36 weeks gestation) or delayed ECV (at or after 37 weeks)...
April 27, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28448765/digital-assays-part-i-partitioning-statistics-and-digital-pcr
#2
Amar S Basu
A digital assay is one in which the sample is partitioned into many small containers such that each partition contains a discrete number of biological entities (0, 1, 2, 3, …). A powerful technique in the biologist's toolkit, digital assays bring a new level of precision in quantifying nucleic acids, measuring proteins and their enzymatic activity, and probing single-cell genotypes and phenotypes. Part I of this review begins with the benefits and Poisson statistics of partitioning, including sources of error...
April 1, 2017: SLAS Technology
https://www.readbyqxmd.com/read/28448725/endogenous-cryptococcal-endophthalmitis-in-immunocompetent-host-case-report-and-review-of-multimodal-imaging-findings-and-treatment
#3
Atchara Amphornphruet, Sukhum Silpa-Archa, Janine M Preble, C Stephen Foster
PURPOSE: To describe a case of bilateral endogenous cryptococcal endophthalmitis in an immunocompetent host and to review adjunctive ophthalmic imaging patterns and treatment. METHODS: A retrospective case report. RESULTS: A 45-year-old female patient with two distinct presentations of endogenous cryptococcal endophthalmitis in each eye presented initially with progressive blurred vision in the left eye, beginning more than 10 years after a craniotomy with ventriculoperitoneal shunt...
April 27, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28448685/adult-neurobehavioral-alterations-in-male-and-female-mice-following-developmental-exposure-to-paracetamol-acetaminophen-characterization-of-a-critical-period
#4
Gaëtan Philippot, Torsten Gordh, Anders Fredriksson, Henrik Viberg
Paracetamol (acetaminophen) is a widely used non-prescription drug with analgesic and antipyretic properties. Among pregnant women and young children, paracetamol is one of the most frequently used drugs and is considered the first-choice treatment for pain and/or fever. Recent findings in both human and animal studies have shown associations between paracetamol intake during brain development and adverse behavioral outcomes later in life. The present study was undertaken to investigate if the induction of these effects depend on when the exposure occurs during a critical period of brain development and if male and female mice are equally affected...
April 27, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28448659/evaluation-of-ecological-momentary-assessment-for-tinnitus-severity
#5
Rachel L Goldberg, Marilyn L Piccirillo, Joyce Nicklaus, Andrew Skillington, Eric Lenze, Thomas L Rodebaugh, Dorina Kallogjeri, Jay F Piccirillo
Importance: Existing patient-reported outcome measures of tinnitus assess the severity and disability retrospectively, which may result in adequate reliability, but cannot capture the fluctuating and individualized nature of tinnitus. Experience sampling may provide an alternative. Objective: To use an ecological momentary assessment (EMA) to measure tinnitus disability and associated constructs. Design, Setting, and Participants: Forty adults with tinnitus provided self-report of their tinnitus bother using 5 questions measured by EMA, as well as standard retrospective outcome measures...
April 27, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28448568/inhibitory-effects-of-fenretinide-metabolites-n-4-methoxyphenyl-retinamide-mpr-and-4-oxo-n-4-hydroxyphenyl-retinamide-3-keto-hpr-on-fenretinide-molecular-targets-%C3%AE-carotene-oxygenase-1-stearoyl-coa-desaturase-1-and-dihydroceramide-%C3%AE-4-desaturase-1
#6
Eugenia Poliakov, William Samuel, Todd Duncan, Danielle B Gutierrez, Nathan L Mata, T Michael Redmond
The therapeutic capacity of fenretinide (N-[4-hydroxyphenyl] retinamide; 4-HPR) has been demonstrated for several conditions, including cancer, obesity, diabetes, and ocular disease. Yet, the mechanisms of action for its pleiotropic effects are still undefined. We hypothesized that investigation of two of the major physiological metabolites of fenretinide, N-[4-methoxyphenyl]retinamide (MPR) and 4-oxo-N-(4-hydroxyphenyl)retinamide (3-keto-HPR), might begin to resolve the multifaceted effects of this synthetic retinoid...
2017: PloS One
https://www.readbyqxmd.com/read/28448564/insights-into-the-biochemical-defence-and-methylation-of-the-solitary-bee-osmia-rufa-l-a-foundation-for-examining-eusociality-development
#7
Aneta Strachecka, Jacek Chobotow, Jerzy Paleolog, Aleksandra Łoś, Michał Schulz, Dariusz Teper, Halina Kucharczyk, Maciej Grzybek
We examined age-related biochemical and histological changes in the fat bodies and hemolymph of Osmia rufa males and females. We analysed solitary bees during diapause, in October and in April; as well as the flying insects following diapause, in May and June. The trophocyte sizes, as well as the numbers of lipid droplets were the greatest at the beginning of diapause. Subsequently, they decreased along with age. Triglyceride and glucose concentrations systematically decreased in fat body cells but increased in the hemolymph from October to June...
2017: PloS One
https://www.readbyqxmd.com/read/28448364/deep-tissue-pressure-injury-a-clinical-review
#8
Ave Preston, Aditi Rao, Robyn Strauss, Rebecca Stamm, Demetra Zalman
: A deep tissue pressure injury (DTPI) is a serious type of pressure injury that begins in the muscle closest to the bone and may not be visible in its early stages. Its hallmark is rapid deterioration despite the use of appropriate preventive interventions. In 2007, the National Pressure Ulcer Advisory Panel added suspected deep tissue injuries to the traditional classification system, and by 2010 DTPIs had accounted for about 9% of all pressure injuries and were for the first time more prevalent than stage 3 or 4 pressure injuries...
May 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/28448278/reliability-and-fall-risk-detection-for-the-bestest-and-mini-bestest-in-older-adults
#9
Eric Anson, Elizabeth Thompson, Lei Ma, John Jeka
BACKGROUND & PURPOSE: Test stability and test-retest reliability have not previously been reported for either the Balance Evaluation Systems Test (BESTest) or mini-BESTest (mBEST) in a population of older adults with nonspecific balance limitations. Furthermore, no criterion for identifying change greater than chance has been reported in older adults with nonspecific balance problems using either BESTest or mBEST scores. The purposes of this study were to determine test stability over time, test-retest reliability, to identify minimum detectable change for the BESTest and mBEST in a population of older adults with nonspecific balance problems...
April 26, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/28448181/blood-pressure-control-with-cilnidipine-treatment-in-japanese-post-stroke-hypertensive-patients-the-ca-attend-study
#10
Shiro Aoki, Naohisa Hosomi, Tomohisa Nezu, Tsukasa Teshima, Hitoshi Sugii, Shinobu Nagahama, Yoshiki Kurose, Hirofumi Maruyama, Masayasu Matsumoto
Blood pressure control is important in post-stroke hypertensive patients and antihypertensive treatment is recommended for such patients. Ca-channel blockers are recommended as the medications of choice for the treatment of post-stroke patients. Here, we report the results of a large-scale prospective post-marketing surveillance study of post-stroke hypertensive patients (n = 2667, male 60.4%, 69.0 ± 10.9 years) treated with cilnidipine, with regard to blood pressure control and adverse reactions. Cilnidipine treatment caused a decrease in both clinic and home blood pressures 2 months after the beginning of treatment, and the decreased blood pressure was maintained until the end of 12 months' observation...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28448035/bioluminescence-imaging-of-neuroinflammation-in-transgenic-mice-after-peripheral-inoculation-of-alpha-synuclein-fibrils
#11
Sara Breid, Maria E Bernis, Julius B Tachu, Maria C Garza, Holger Wille, Gültekin Tamgüney
To study the prion-like behavior of misfolded alpha-synuclein, mouse models are needed that allow fast and simple transmission of alpha-synuclein prionoids, which cause neuropathology within the central nervous system (CNS). Here we describe that intraglossal or intraperitoneal injection of alpha-synuclein fibrils into bigenic Tg(M83(+/-):Gfap-luc(+/-)) mice, which overexpress human alpha-synuclein with the A53T mutation from the prion protein promoter and firefly luciferase from the promoter for glial fibrillary acidic protein (Gfap), is sufficient to induce neuropathologic disease...
April 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28448011/turbidimetry-on-human-washed-platelets-the-effect-of-the-pannexin1-inhibitor-brilliant-blue-fcf-on-collagen-induced-aggregation
#12
Filippo Molica, Séverine Nolli, Pierre Fontana, Brenda Renata Kwak
Turbidimetry is a laboratory technique that is applied to measure the aggregation of platelets suspended in either plasma (platelet-rich plasma, PRP) or in buffer (washed platelets), by the use of one or a combination of agonists. The use of washed platelets separated from their plasma environment and in the absence of anticoagulants allows for studying intrinsic platelet properties. Among the large panel of agonists, arachidonic acid (AA), adenosine di-phosphate (ADP), thrombin and collagen are the most frequently used...
April 6, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447996/task-interruption-and-resumption-paradigm-for-testing-the-activation-and-pursuit-of-an-abstract-thinking-goal
#13
Jae-Eun Namkoong, Marlone D Henderson
This protocol is based on the task interruption and resumption paradigm, the premise of which is that active goals lead to persistent behavior and thus a higher resumption rate after a period of delay or interruption. The task interruption and resumption protocol described in this research is tailored to test the activation of cognitive goals (e.g., a goal to think more abstractly). Cognitive goals may be pursued even during the interruption period; thus, to prevent this, the protocol involves cognitive distraction...
April 18, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447885/recovery-from-coma-post-cardiac-arrest-is-dependent-on-the-orexin-pathway
#14
Young-Jin Kang, Guilian Tian, Afsheen Bazrafkan, Maryam H Farahabadi, Matine Azadian, Hamidreza Abbasi, Brittany Shamaoun, Oswald Steward, Yama Akbari
Cardiac arrest affects >550,000 people annually in the USA while 80-90% of survivors suffer from a comatose state. Arousal from coma is critical for recovery but mechanisms of arousal are undefined. Orexin-A, a hypothalamic excitatory neuropeptide, has been linked to arousal deficits in various brain injuries. We investigated the orexinergic system's role in recovery from cardiac arrest-related neurological impairments, including arousal deficits. Using an asphyxial cardiac arrest and resuscitation model in rats, we examine neurological recovery post-resuscitation in conjunction with changes in orexin-A levels in cerebrospinal fluid and orexin-expressing neurons...
April 27, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28447582/training-the-next-generation-of-canadian-clinician-scientists-charting-a-path-to-success
#15
Charles Yin, Patrick E Steadman, Tavis Apramian, Tianwei E Zhou, Abdullah Ishaque, Xin Wang, Alexandra Kuzyk, Nebras Warsi
Clinician-scientists are physicians with training in both clinical medicine and research that enables them to occupy a unique niche as specialists in basic and translational biomedical research. While there is widespread acknowledgement of the importance of clinician-scientists in today's landscape of evidence-based medical practice, training of clinician-scientists in Canada has been on the decline, with fewer opportunities to obtain funding. With the increasing length of training and lower financial compensation, fewer medical graduates are choosing to pursue such a career...
April 26, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/28447380/lncrna-h19-modulates-wnt-%C3%AE-catenin-signaling-by-targeting-dkk4-in-hindlimb-unloaded-rat
#16
Bing Li, Jun Liu, Jie Zhao, Jian-Xiong Ma, Hao-Bo Jia, Yang Zhang, Guo-Sheng Xing, Xin-Long Ma
OBJECTIVE: To investigate the biological functions of long noncoding RNA-H19 (H19) in the pathogenesis of disuse osteoporosis (DOP). METHODS: Fifty-four male Sprague Dawley (SD) rats were randomly divided into three groups: baseline control (BC, 6), age-matched control (AC, 24), and hindlimb unloading (HLU, 24). The rats in the BC group were sacrificed at the beginning of the experiment, while the AC and HLU rats were sacrificed at different times (7, 14, 21 and 28 days after HLU)...
April 26, 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28447312/bone-quality-in-chronic-kidney-disease-definitions-and-diagnostics
#17
REVIEW
Erin M B McNerny, Thomas L Nickolas
PURPOSE OF REVIEW: In this paper, we review the epidemiology, diagnosis, and pathogenesis of fractures and renal osteodystrophy. RECENT FINDINGS: The role of bone quality in the pathogenesis of fracture susceptibility in chronic kidney disease (CKD) is beginning to be elucidated. Bone quality refers to bone material properties, such as cortical and trabecular microarchitecture, mineralization, turnover, microdamage, and collagen content and structure. Recent data has added to our understanding of the effects of CKD on alterations to bone quality, emerging data on the role of abnormal collagen structure on bone strength, the potential of non-invasive methods to inform our knowledge of bone quality, and how we can use these methods to inform strategies that protect against bone loss and fractures...
April 26, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28447243/the-longitudinal-association-of-relationship-quality-and-reoffending-among-first-time-juvenile-offenders-and-their-mothers
#18
Caitlin Cavanagh, Elizabeth Cauffman
To understand how youth desist from crime after their first arrest, it is necessary to investigate their primary support system: their parents. As such, this study examined the reciprocal effects of justice system contact on the mother-child dyad. Interviews with 317 mothers and their sons from Orange County, CA, Jefferson Parish, LA, and Philadelphia, PA were conducted semiannually over two and a half years. At the beginning of the study, the sons were first-time offenders aged 13-17 and mostly non-White (i...
April 26, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28447231/the-nutritional-interrelationship-between-the-growing-and-finishing-phases-in-crossbred-cattle-raised-in-a-tropical-system
#19
Ricardo Linhares Sampaio, Flávio Dutra de Resende, Ricardo Andrade Reis, Ivanna Moraes de Oliveira, Letícia Custódio, Rodolfo Maciel Fernandes, Raul Dirceu Pazdiora, Gustavo Rezende Siqueira
This study evaluated the nutritional interrelationship between the growing and finishing phases of crossbred cattle in determining their performance. One hundred and eight animals were used (8 months old, body weight [BW] 211 ± 20 kg). During the dry season, the animals received one of the following supplements: a mineral plus urea supplement (ad libitum, MSD), a protein supplement (1 g/kg BW per day, PR1), or a protein-energy supplement (5 g/kg BW per day, PE). During the rainy season, the animals received one of the following supplements: a mineral without urea supplement (ad libitum, MSR), a protein supplement (1 g/kg BW per day, PR2), or PE (5 g/kg BW per day)...
April 26, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28447077/evidence-europe-2017-london-uk-february-22-23-2017
#20
A Kibble
As the political backdrop changes in both the U.S. and Europe, volatility in the pharma industry is beginning to be felt as the sector becomes sensitive to the uncertainty. U.S. President Trump has stated he will pursue an agenda against high U.S. drug prices and is expected to seek to repeal the Affordable Care Act, while in Europe, Brexit casts further unknowns in regulatory authorization procedures, trade and external reference pricing. With these factors in mind, Terrapin's Evidence Europe meeting provided for a very topical discussion on the use of evidence to define and communicate value in healthcare...
March 2017: Drugs of Today
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