Read by QxMD icon Read


Jennifer N Clements, Tiffaney Threatt, Eileen Ward, Kayce M Shealy
Concentrated insulin analogs have recently been approved and are available for clinical use in the management of diabetes mellitus. One new product is insulin glargine U-300 (Sanofi), a basal concentrated insulin of 300 U/mL. Several studies have been conducted and completed evaluating blood samples for the pharmacokinetics of insulin glargine U-300 and euglycemic clamp procedures for the pharmacodynamics. This concentrated insulin has a low within-day variability and high day-to-day reproducibility, allowing for a more constant and prolonged duration of action, compared with insulin glargine U-100 (100 U/mL)...
October 4, 2016: Clinical Pharmacokinetics
Cortney M Mospan
Two concentrated analog insulins, long-acting insulin glargine U-300 (Toujeo) and rapid-acting insulin lispro (Humalog U-200), were recently approved by the FDA. Providers must be aware of clinical differences in these new product formulations compared with their nonconcentrated formulations, so that they can select appropriate patients for these products and minimize drug errors.
June 2016: JAAPA: Official Journal of the American Academy of Physician Assistants
Meagan A Brown, Courtney S Davis, Laurie W Fleming, Joshua W Fleming
PURPOSE: The purpose of this article is to educate nurse practitioners about the role of Toujeo®, insulin glargine U-300 (Gla-300), which is a new option for the treatment of diabetes mellitus. DATA SOURCES: A comprehensive literature search was conducted using MEDLINE with the key terms: insulin glargine 300, Toujeo, Gla-300, and EDITION for clinical trial data. Other resources included package inserts, drug information websites, and the World Health Organization (WHO)...
September 2016: Journal of the American Association of Nurse Practitioners
Jennifer N Clements, Larkin Bello
PURPOSE: The pharmacokinetics, efficacy, and safety of U-300 insulin glargine for the management of diabetes are reviewed. SUMMARY: U-300 (300 units/mL) insulin glargine is a long-acting basal insulin with low within-day variability, high day-to-day reproducibility, longer duration, and constant pharmacokinetic profile compared with U-100 (100 units/mL) insulin glargine. U-300 was evaluated in six randomized, active-comparator, open-label, Phase III clinical studies (EDITION trials) among patients with type 1 or 2 diabetes...
March 15, 2016: American Journal of Health-system Pharmacy: AJHP
Joan S Grant, Lucinda J Graven
No abstract text is available yet for this article.
March 2016: Home Healthcare Now
Thomas Pepper, Georgina Hicks, Stephen Glass, John Philpott-Howard
In healthcare, fabric or metal-bead lanyards are universally used for carrying identity cards. However there is little information on microbial contamination with potential pathogens that may readily re-contaminate disinfected hands. We examined 108 lanyards from hospital staff. Most grew skin flora but 7/108 (6%) had potentially pathogenic bacteria: four grew methicillin-susceptible Staphylococcus aureus, and four grew probable fecal flora: 3 Clostridium perfringens and 1 Clostridium bifermentans (one lanyard grew both S...
November 2014: Journal of Infection and Public Health
Ü Ören, M Hansson, S Mattsson, C L Rääf
A comparison has been carried out between standard-dose computed tomography, non-diagnostic computed tomography and digital radiography with respect to their suitability for detecting radioactive fragments associated with nuclear or radiological events such as debris from radiological dispersal devices. The purpose was to investigate if radiographic imaging is justified for the detection and localisation of radioactive fragments in affected patients. Fragments of uranium (U), copper (Cu), iron (Fe) and volcanic ash with effective diameters ranging from (approximately) 100 to 700 μm were selected...
March 2014: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
Claudia Battista, Raffaella Viti, Salvatore Minisola, Iacopo Chiodini, Vincenzo Frusciante, Alfredo Scillitani, Vincenzo Carnevale
OBJECTIVE: To describe the biochemical effects of an over-supplementation of vitamin D3 in two patients with primary hyperparathyroidism (PHPT). DESIGN: Two patients (A and B) with PHPT took erroneously 2,400,000 U (300,000 U/day for 8 days) and 4,500,000 U (300,000 U/day for 15 days) of cholecalciferol, respectively. They were followed for 4 months and ionized calcium, creatinine, PTH, 25 hydroxy-vitamin D, 1,25(OH)₂D and urinary calcium/creatinine levels were measured...
October 2013: Hormones: International Journal of Endocrinology and Metabolism
Ligang Xue, Kristian Handberg Mikkelsen
OBJECTIVES: The objective of this study was to assess the dose accuracy of NovoPen® 5 in delivering low, medium and high doses of insulin before and after simulated lifetime use. A secondary objective was to evaluate the durability of the pen and its memory function under various stress conditions designed to simulate conditions that may be encountered in everyday use of an insulin pen. RESEARCH DESIGN AND METHODS: All testing was conducted according to International Organization for Standardization guideline 11608-1, 2000 for pen injectors...
March 2013: Expert Opinion on Drug Delivery
Hsu Chen Hsu, Chen-Lin Liu, Yuan Chin Hsu, Chi-Kung Ni
The methylation effects in the energy transfer between Kr atoms and highly vibrationally excited 2-methylnaphthalene in the triplet state were investigated using crossed-beam/time-sliced velocity-map ion imaging at a translational collision energy of approximately 520 cm(-1). Comparison of the energy transfer between naphthalene and 2-methylnaphthalene shows that the difference in total collisional cross section and the difference in energy transfer probability density functions are small. The ratio of the total cross sections is sigma(naphthalene): sigma(methylnaphthalene)=1...
July 28, 2008: Journal of Chemical Physics
Kazuaki Miyagishima, Takeshi Kawaguchi
OBJECTIVE: In this study, we aimed at examining how disparities in selected medical care resources across secondary medical care sectors (SMCSs) changed over a twelve-year period following the introduction of the Medical Care Plan. METHODS: Changes in all SMCS boundaries prior to 2002 were identified from data published by the Ministry of Health and Welfare and prefectural governments. The per capita numbers of ordinary hospital beds and X-ray computed tomography (CT) scanners in hospitals were chosen as indicators of medical care resources, representing respectively mandatory and nonmandatory components of the Medical Care Plan...
September 2006: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
S A Gould, E E Moore, D B Hoyt, J M Burch, J B Haenel, J Garcia, R DeWoskin, G S Moss
BACKGROUND: Human polymerized hemoglobin (PolyHeme) is a universally compatible, disease-free, oxygen-carrying resuscitative fluid. This is the first prospective, randomized trial to compare directly the therapeutic benefit of PolyHeme with that of allogeneic red blood cells (RBCs) in the treatment of acute blood loss. STUDY DESIGN: Forty-four trauma patients (33 male, 11 female) aged 19-75 years with an average Injury Severity Score (ISS) score of 21+/-10 were randomized to receive red cells (n = 23) or up to 6 U (300 g) of PolyHeme (n = 21) as their initial blood replacement after trauma and during emergent operations...
August 1998: Journal of the American College of Surgeons
H A Roels, F J Van Assche, M Oversteyns, M De Groof, R R Lauwerys, D Lison
The study aimed at assessing the evolution of cadmium (Cd)-induced renal tubular dysfunction in Cd workers according to the severity of the microproteinuria observed at the time the exposure was substantially decreased. Male workers employed in the Cd production industry for whom formerly high exposure had markedly decreased by 1984 and for whom standardized medical data were available during two observation periods (1980-1984 and 1990-1992) were eligible for the study. A total of 32 Cd workers fulfilling this profile were divided into two groups on the basis of historical records of urinary Cd concentration (Cd-U) covering the period until 1984...
May 1997: American Journal of Industrial Medicine
J W Tams, K G Welinder
The unfolding and refolding rates of the heme-and Ca2+ -containing Coprinus cinereus peroxidase (CIP) have been measured at pH 12.1, in 4 M urea, and at 61.2 degrees C. The change in peroxidase activity paralleled the change in the Soret band absorbance of the heme group. The unfolding rate constant (ku), was determined independently in thermolysin digestion and EDTA experiments at 59.4 degrees C. Both gave ku values of 1.5 ms-1, and also showed that the presence of 4 mM EDTA made CIP unfolding practically irreversible...
June 11, 1996: Biochemistry
H Tilg, W Vogel, J Tratkiewicz, W E Aulitzky, M Herold, M Gruber, D Geissler, F Umlauft, G Judmaier, U Schwulera
Ten patients with chronic hepatitis B received increasing doses of nIL-2 (30,000 U, 100,000 U, 300,000 U, 1.0 million U) subcutaneously in a phase I trial. Each dose was applied once per week over 3 weeks. Serum samples were taken before and 2, 12, 24, 48 and 72 h after the first application of each dose level. Serum concentrations of interleukin-1 (IL-1), IL-2, IL-6, interferon-alfa (IFN-alpha), IFN-gamma, tumor necrosis factor-alpha (TNF-alpha) and GM-CSF as well as the cytokine-dependent serum components neopterin, beta-2-microglobulin (B2M), C-reactive protein (CPR), soluble IL-2-receptor (sIL-2R) and 2'-5'-oligoadenylate synthetase (2-5 OA) were assayed using ELISAs and RIAs...
September 1993: Journal of Hepatology
N Caputo, C Chiurulla, E Cianciulli, E Ciorba, P Floridi, G P Pelliccioli, O Capponi, E Signorini
610 sacrorodiculographic and myelographic examinations were carried out injecting at lumbar level Iopamidol at 200, 300 and 370 mg I/ml concentrations. Immediate and early complications have been noticed in 18,52% of cases, i.e. sensation of pain during contrast injection, headache, nausea, vomit, neck stiffness, photophobia, epilepsy. In sacrorodiculographic examinations, side effects especially occurred by using 370 mg I/ml concentrations; in lumbar and thoracic myelographies, incidence of complications did not statistically differ by uing 300 or 370 mg I/ml concentrations...
March 1981: Rivista di Patologia Nervosa e Mentale
M J Twery, J F Obie, C W Cooper
Synthetic salmon calcitonin (sCT) given SC (30 MRC U/kg) or ICV (1.4 U, 300 ng) inhibited 24-hr food consumption in the rat by 50-100%. Furthermore, ICV doses of sCT ranging from 75 ng (0.35 U) to 300 ng (1.4 U) lowered both food and water intake in a dose-dependent manner. Use of various forms of CT give an apparent order of potency of salmon greater than porcine greater than or equal to human with sCT being at least 40 fold more potent than the mammalian forms. Measurement of food and water intake over a brief (30-90 min) period showed that ICV sCT was effective in reducing food and water consumption regardless of whether it had been given 1, 12, or 23 hr previously...
September 1982: Peptides
B Völkers, A Ganser, J Greher, C C Stella, D Hoelzer
The effect of human recombinant tumor necrosis factor (rhTNF-alpha) on the in vitro colony growth of normal hematopoietic progenitor cells was investigated. In a clonal colony-assay a dose-dependent inhibition of erythroid BFU-E, granulocyte/monocyte CFU-GM and megakaryocyte CFU-Mk was demonstrated. CFU-Mk were completely inhibited by low doses of TNF-alpha (3 U-300 U/ml). 50% inhibition occurred at 10 U/ml of TNF for CFU-Mk, 100% inhibition at 300 U/ml of TNF. 50% inhibition occurred at 233 U/ml of TNF for CFU-GM, and 100% inhibition for CFU-GM was not observed...
June 1989: Onkologie
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"