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https://www.readbyqxmd.com/read/29441588/the-role-of-stim-proteins-in-neutrophil-functions
#1
Nicolas Demaurex, Stephanie Saul
STIM proteins regulate store-operated Ca2+entry (SOCE) in innate and adaptive immune cells and participate to the Ca2+signals that control the functions of neutrophils, the first line of host defence against bacterial and fungal infections. Loss of function experiments in animal and cellular models indicate that both STIM1 and STIM2 regulate neutrophil functions, but the complexity of the SOCE machinery and the versatility of neutrophils complicate the evaluation of the results. This review aims to summarize the latest progress in the field with a special attention to the details of the experimental designs...
February 14, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29433467/effect-of-tendon-vibration-during-wide-pulse-neuromuscular-electrical-stimulation-nmes-on-muscle-force-production-in-people-with-spinal-cord-injury-sci
#2
Vanesa Bochkezanian, Robert U Newton, Gabriel S Trajano, Amilton Vieira, Timothy S Pulverenti, Anthony J Blazevich
BACKGROUND: Neuromuscular electrical stimulation (NMES) is commonly used in skeletal muscles in people with spinal cord injury (SCI) with the aim of increasing muscle recruitment and thus muscle force production. NMES has been conventionally used in clinical practice as functional electrical stimulation (FES), using low levels of evoked force that cannot optimally stimulate muscular strength and mass improvements, and thus trigger musculoskeletal changes in paralysed muscles. The use of high intensity intermittent NMES training using wide-pulse width and moderate-intensity as a strength training tool could be a promising method to increase muscle force production in people with SCI...
February 13, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29425369/auditory-stimulation-of-sleep-slow-oscillations-modulates-subsequent-memory-encoding-through-altered-hippocampal-function
#3
Ju Lynn Ong, Amiya Patanaik, Nicholas I Y N Chee, Xuan Kai Lee, Jia-Hou Poh, Michael W L Chee
Study Objectives: Slow oscillations (SO) during sleep contribute to the consolidation of learned material. How the encoding of declarative memories during subsequent wakefulness might benefit from their enhancement during sleep is less clear. In this study, we aimed to investigate the impact of acoustically enhanced SO during a nap on subsequent encoding of declarative material. Methods: Thirty-seven healthy young adults were studied under two conditions: stimulation (STIM) and no stimulation (SHAM), in counter-balanced order following a night of sleep restriction (4h time-in-bed; TIB)...
February 7, 2018: Sleep
https://www.readbyqxmd.com/read/29410385/functional-magnetic-resonance-imaging-evaluation-of-auricular-percutaneous-electrical-neural-field-stimulation-for-fibromyalgia-protocol-for-a-feasibility-study
#4
Melat Gebre, Anna Woodbury, Vitaly Napadow, Venkatagiri Krishnamurthy, Lisa C Krishnamurthy, Roman Sniecinski, Bruce Crosson
BACKGROUND: Fibromyalgia is a chronic pain state that includes widespread musculoskeletal pain, fatigue, psychiatric symptoms, cognitive and sleep disturbances, and multiple somatic symptoms. Current therapies are often insufficient or come with significant risks, and while there is an increasing demand for non-pharmacologic and especially non-opioid pain management such as that offered through complementary and alternative medicine therapies, there is currently insufficient evidence to recommend these therapies...
February 6, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29363328/molecular-physiology-and-pathophysiology-of-stromal-interaction-molecules
#5
Heather A Nelson, Michael W Roe
Ca2+ release from the endoplasmic reticulum is an important component of Ca2+ signal transduction that controls numerous physiological processes in eukaryotic cells. Release of Ca2+ from the endoplasmic reticulum is coupled to the activation of store-operated Ca2+ entry into cells. Store-operated Ca2+ entry provides Ca2+ for replenishing depleted endoplasmic reticulum Ca2+ stores and a Ca2+ signal that regulates Ca2+-dependent intracellular biochemical events. Central to connecting discharge of endoplasmic reticulum Ca2+ stores following G protein-coupled receptor activation with the induction of store-operated Ca2+ entry are stromal interaction molecules (STIM1 and STIM2)...
January 1, 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29351410/hypoxia-selectively-upregulates-cation-channels-and-increases-cytosolic-ca2-in-pulmonary-but-not-coronary-arterial-smooth-muscle-cells
#6
Xi He, Shanshan Song, Ramon J Ayon, Angela Balisterieri, Stephen M Black, Ayako Makino, W Gil Wier, Wei-Jin Zang, Jason X-J Yuan
Ca2+ signaling, particularly the mechanism via store-operated Ca2+ entry (SOCE) and receptor-operated Ca2+ entry (ROCE), plays a critical role in the development of acute hypoxia-induced pulmonary vasoconstriction and chronic hypoxia-induced pulmonary hypertension. This study aimed to test the hypothesis that chronic hypoxia differentially regulates the expression of proteins that mediate SOCE and ROCE (STIM, Orai, and TRPC6) in pulmonary (PASMC) and coronary (CASMC) artery smooth muscle cells. The resting cytosolic [Ca2+] ([Ca2+]cyt) and the stored [Ca2+] in the sarcoplasmic reticulum (SR) were not different in CASMC and PASMC...
January 3, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29337674/a-study-on-blocking-store-operated-ca2-entry-in-pulmonary-arterial-smooth-muscle-cells-with-xyloketals-from-marine-fungi
#7
Jie-Bin Zhou, Ying-Ying Sun, Ying-Lin Zheng, Chu-Qin Yu, Hua-Qing Lin, Ji-Yan Pang
In this study, the effect of four xyloketals 1-4 on store-operated calcium entry (SOCE) was investigated in primary distal pulmonary arterial smooth muscle cells (PASMCs) isolated from mice. The results showed that xyloketal A (1), an unusual ketal with C-3 symmetry, exhibited strong SOCE blocking activity. Secretion of interleukin-8 (IL-8) was also inhibited by xyloketal A. The parallel artificial membrane permeability assay (PAMPA) of 1-4 suggested that these xyloketals penetrated easily through the cell membrane...
December 20, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29298434/coiled-coil-formation-conveys-a-stim1-signal-from-er-lumen-to-cytoplasm
#8
Nupura Hirve, Vangipurapu Rajanikanth, Patrick G Hogan, Aparna Gudlur
STIM1 and STIM2 are endoplasmic reticulum (ER) membrane proteins that sense decreases in ER-luminal free Ca2+ and, through a conformational change in the STIM cytoplasmic domain, control gating of the plasma membrane Ca2+ channel ORAI1. To determine how STIM1 conveys a signal from the ER lumen to the cytoplasm, we studied the Ca2+-dependent conformational change of engineered STIM1 proteins in isolated ER membranes and, in parallel, physiological activation of these proteins in cells. We find that conserved "sentinel" features of the CC1 region help to prevent activation while Ca2+ is bound to STIM ER-luminal domains...
January 2, 2018: Cell Reports
https://www.readbyqxmd.com/read/29297249/stim-proteins-as-regulators-of-neuronal-store-operated-calcium-influx
#9
Elena Popugaeva, Ilya Bezprozvanny
No abstract text is available yet for this article.
January 3, 2018: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/29289652/cellular-mechanisms-of-metabolic-syndrome-related-atrial-decompensation-in-a-rat-model-of-hfpef
#10
Felix Hohendanner, David Bode, Uwe Primessnig, Tim Guthof, Rafael Doerr, Sarah Jeuthe, Sophie Reimers, Kun Zhang, Doris Bach, Paulina Wakula, Burkert M Pieske, Frank R Heinzel
Heart failure (HF) with preserved ejection fraction (HFpEF) is present in about 50% of HF patients. Atrial remodeling is common in HFpEF and associated with increased mortality. We postulate that atrial remodeling is associated with atrial dysfunction in vivo related to alterations in cardiomyocyte Calcium (Ca) signaling and remodeling. We examined atrial function in vivo and Ca transients (CaT) (Fluo4-AM, field stim) in atrial cardiomyocytes of ZSF-1 rats without (Ln; lean hypertensive) and with metabolic syndrome (Ob; obese, hypertensive, diabetic) and HFpEF...
December 28, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29243589/defective-stim-mediated-store-operated-ca2-entry-in-hepatocytes-leads-to-metabolic-dysfunction-in-obesity
#11
Ana Paula Arruda, Benedicte Mengel Pers, Günes Parlakgul, Ekin Güney, Ted Goh, Erika Cagampan, Grace Yankun Lee, Renata L Goncalves, Gökhan S Hotamisligil
Defective Ca2+ handling is a key mechanism underlying hepatic endoplasmic reticulum (ER) dysfunction in obesity. ER Ca2+ level is in part monitored by the store-operated Ca2+ entry (SOCE) system, an adaptive mechanism that senses ER luminal Ca2+ concentrations through the STIM proteins and facilitates import of the ion from the extracellular space. Here, we show that hepatocytes from obese mice displayed significantly diminished SOCE as a result of impaired STIM1 translocation, which was associated with aberrant STIM1 O-GlycNAcylation...
December 15, 2017: ELife
https://www.readbyqxmd.com/read/29232117/all-fullerene-based-cells-for-non-aqueous-redox-flow-batteries
#12
Jochen Friedl, Maria A Lebedeva, Kyriakos Porfyrakis, Ulrich Stimming, Thomas W Chamberlain
Redox flow batteries have the potential to revolutionize our use of intermittent sustainable energy sources such as solar and wind power by storing the energy in liquid electrolytes. Our concept study utilizes a novel electrolyte system, exploiting derivatised fullerenes as both anolyte and catholyte species in a series of battery cells, including a symmetric, single species system which alleviates the common problem of membrane crossover. The prototype multi electron system, utilizing molecular based charge carriers, made from inexpensive, abundant and sustainable materials, principally, C and Fe, demonstrates remarkable current and energy densities and promising long-term cycling stability...
December 12, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29217255/forms-and-functions-of-store-operated-calcium-entry-mediators-stim-and-orai
#13
REVIEW
James W Putney
Calcium signals arise by multiple mechanisms, including mechanisms of release of intracellular stored Ca2+, and the influx of Ca2+ through channels in the plasma membrane. One mechanism that links these two sources of Ca2+ is store-operated Ca2+ entry, the most commonly encountered version of which involves the extensively studied calcium-release-activated Ca2+ (CRAC) channel. The minimal and essential molecular components of the CRAC channel are the STIM proteins that function as Ca2+ sensors in the endoplasmic reticulum, and the Orai proteins that comprise the pore forming subunits of the CRAC channel...
November 22, 2017: Advances in Biological Regulation
https://www.readbyqxmd.com/read/29203863/orai-channels-are-critical-for-receptor-mediated-endocytosis-of-albumin
#14
Bo Zeng, Gui-Lan Chen, Eliana Garcia-Vaz, Sunil Bhandari, Nikoleta Daskoulidou, Lisa M Berglund, Hongni Jiang, Thomas Hallett, Lu-Ping Zhou, Li Huang, Zi-Hao Xu, Viji Nair, Robert G Nelson, Wenjun Ju, Matthias Kretzler, Stephen L Atkin, Maria F Gomez, Shang-Zhong Xu
Impaired albumin reabsorption by proximal tubular epithelial cells (PTECs) has been highlighted in diabetic nephropathy (DN), but little is known about the underlying molecular mechanisms. Here we find that ORAI1-3, are preferentially expressed in PTECs and downregulated in patients with DN. Hyperglycemia or blockade of insulin signaling reduces the expression of ORAI1-3. Inhibition of ORAI channels by BTP2 and diethylstilbestrol or silencing of ORAI expression impairs albumin uptake. Transgenic mice expressing a dominant-negative Orai1 mutant (E108Q) increases albuminuria, and in vivo injection of BTP2 exacerbates albuminuria in streptozotocin-induced and Akita diabetic mice...
December 4, 2017: Nature Communications
https://www.readbyqxmd.com/read/29202109/ylmd-and-ylme-genes-are-dispensable-for-growth-cross-wall-formation-and-sporulation-in-streptomyces-venezuelae
#15
Fernando Santos-Beneit, Jing-Ying Gu, Ulrich Stimming, Jeff Errington
Streptomycetes are Gram-positive filamentous soil bacteria that grow by tip extension and branching, forming a network of multinucleoid hyphae. These bacteria also have an elaborate process of morphological differentiation, which involves the formation of an aerial mycelium that eventually undergoes extensive septation into chains of uninucleoid cells that further metamorphose into spores. The tubulin-like FtsZ protein is essential for this septation process. Most of the conserved cell division genes (including ftsZ) have been inactivated in Streptomyces without the anticipated lethality, based on studies of many other bacteria...
November 2017: Heliyon
https://www.readbyqxmd.com/read/29191867/editorial-countering-immune-regulation-stim-ulating-sle-disease-pathogenesis
#16
EDITORIAL
Kiera L Clayton, Mario M Ostrowski
No abstract text is available yet for this article.
December 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29177996/heavy-metal-speciation-redistribution-in-solid-phase-and-potential-environmental-risk-assessment-during-the-conversion-of-msw-incineration-fly-ash-into-molten-slag
#17
Jingde Luan, Meiyun Chai, Yawei Liu, Xin Ke
The alkalinity (AKash), BCR sequential extraction method, and principle component analysis (PCA) were adopted to investigate the heavy-metal partitioning and their speciation redistribution in solid phase in ash-melting process. The results indicated that the conversion of Zn-OXI (oxidisable fraction) into Zn-RES (residual fraction) and the decomposition of Cu-OXI fraction were prevailing in solid-phase reaction. Moreover, the alkalinity reduction from AKash = 2.0 to AKash = 1.2 had positive implications for the concentration reduction of As-RED (reducible fraction), Zn-RED, and Pb-RES fractions in slags...
November 24, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29174271/effects-of-pulsed-electromagnetic-field-therapy-at-different-frequencies-and-durations-on-rotator-cuff-tendon-to-bone-healing-in-a-rat-model
#18
Julianne Huegel, Daniel S Choi, Courtney A Nuss, Mary C C Minnig, Jennica J Tucker, Andrew F Kuntz, Erik I Waldorff, Nianli Zhang, James T Ryaby, Louis J Soslowsky
BACKGROUND: Rotator cuff tears affect millions of individuals each year, often requiring surgical intervention. However, repair failure remains common. We have previously shown that pulsed electromagnetic field (PEMF) therapy improved tendon-to-bone healing in a rat rotator cuff model. The purpose of this study was to determine the influence of both PEMF frequency and exposure time on rotator cuff healing. METHODS: Two hundred ten Sprague-Dawley rats underwent acute bilateral supraspinatus injury and repair followed by either Physio-Stim PEMF or high-frequency PEMF therapy for 1, 3, or 6 hours daily...
November 22, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29120219/how-to-change-conscientiousness-the-sociogenomic-trait-intervention-model
#19
Brent W Roberts, Patrick L Hill, Jordan P Davis
Conscientiousness, the propensity to be organized, responsible, self-controlled, industrious, and rule-following, is related to numerous important outcomes including many forms of psychopathology. Given the increasing awareness of the importance of conscientiousness, it is becoming common to want to understand how to foster it. In this paper we first describe and update a recent model that was put forward as a theoretically informed intervention to change conscientiousness. We then consider recent life span theories focused on conscientiousness that might inform how best to use existing interventions as well as identify potential moderators of the effectiveness of intervention...
July 2017: Personality Disorders
https://www.readbyqxmd.com/read/29089980/promises-and-pitfalls-of-immune-based-strategies-for-huntington-s-disease
#20
REVIEW
Gabriela Delevati Colpo, Erin Furr Stimming, Natalia Pessoa Rocha, Antonio Lucio Teixeira
Huntington's disease (HD) is an autosomal-dominant neurodegenerative disease characterized by the selective loss of neurons in the striatum and cortex, leading to progressive motor dysfunction, cognitive decline and behavioral symptoms. HD is caused by a trinucleotide (CAG) repeat expansion in the gene encoding for huntingtin. Several studies have suggested that inflammation is an important feature of HD and it is already observed in the early stages of the disease. Recently, new molecules presenting anti-inflammatory and/or immunomodulatory have been investigated for HD...
September 2017: Neural Regeneration Research
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