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https://www.readbyqxmd.com/read/29031282/dengue-virus-serotypes-1-and-2-responsible-for-major-dengue-outbreaks-in-nepal-clinical-laboratory-and-epidemiological-features
#1
Shyam Prakash Dumre, Renu Bhandari, Geeta Shakya, Sanjaya Kumar Shrestha, Mahamoud Sama Cherif, Prakash Ghimire, Chonticha Klungthong, In-Kyu Yoon, Kenji Hirayama, Kesara Na-Bangchang, Stefan Fernandez
Dengue virus (DENV) is expanding toward previously nonendemic areas. DENV has recently been introduced in Nepal with limited information. We report the clinical features and serotype distribution of DENV in Nepal during the 2010 outbreaks. A total of 1,215 clinical dengue cases at two major hospitals of central and western Nepal were investigated. Demographic, clinical, and laboratory parameters were recorded. Serum specimens were tested for DENV by IgM/IgG enzyme-linked immunosorbent assays (ELISAs) and reverse transcription polymerase chain reaction (RT-PCR)...
October 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29030319/coordination-of-different-complexes-to-copper-ii-and-cobalt-iii-metal-centers-enhances-zika-virus-and-dengue-virus-loads-in-both-arthropod-cells-and-human-keratinocytes
#2
Shovan Dutta, Michael J Celestine, Supreet Khanal, Alexis Huddleston, Colin Simms, Jessa Faye Arca, Amlan Mitra, Loree Heller, Piotr J Kraj, Michel Ledizet, John F Anderson, Girish Neelakanta, Alvin A Holder, Hameeda Sultana
Trace elements such as copper and cobalt have been associated with virus-host interactions. However, studies to show the effect of conjugation of copper(II) or cobalt(III) metal centers to thiosemicarbazone ligand(s) derived from either food additives or mosquito repellent such as 2-acetylethiazole or citral, respectively, on Zika virus (ZIKV) or dengue virus (serotype 2; DENV2) infections have not been explored. In this study, we show that four compounds comprising of thiosemicarbazone ligand derived from 2-acetylethiazole viz...
October 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28993398/the-african-zika-virus-mr-766-is-more-virulent-and-causes-more-severe-brain-damage-than-current-asian-lineage-and-dengue-virus
#3
Qiang Shao, Stephanie Herrlinger, Ya-Nan Zhu, Mei Yang, Forrest Goodfellow, Steven L Stice, Xiao-Peng Qi, Melinda A Brindley, Jian-Fu Chen
The Zika virus (ZIKV) has two lineages, Asian and African, and their impact on developing brains has not been compared. Dengue virus (DENV) is a close family member of ZIKV and co-circulates with ZIKV. Here we performed intracerebral inoculation of embryonic mouse brains with dengue virus 2 (DENV2), and found that DENV2 is sufficient to cause smaller brain size due to increased cell death in neural progenitor cells (NPCs) and neurons. Compared to the currently circulating Asian lineage of ZIKV (MEX1-44), DENV2 grows slower, causes less neuronal death, and fails to cause postnatal animal death...
October 9, 2017: Development
https://www.readbyqxmd.com/read/28991321/-role-of-dendritic-cells-in-infection-by-dengue-virus-targets-for-replication-and-immune-response
#4
Jahnnyer Martínez, Juan C Hernández, Silvio Urcuqui-Inchima
Dengue fever, caused by dengue virus (DENV) infection, is one of the most important diseases in the world, not only due to the high morbidity/mortality rates it causes, but also because of its great economic and social impact in tropical/subtropical countries. DENV infection has a wide range of clinical manifestations ranging from asymptomatic infection or infection with mild symptoms to severe dengue that can lead to death. At present, no etiological treatment or effective globally distributed vaccine against the four DENV serotypes exists...
June 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28986841/murine-models-for-viral-hemorrhagic-fever
#5
Rosana Gonzalez-Quintial, Roberto Baccala
Hemorrhagic fever (HF) viruses, such as Lassa, Ebola, and dengue viruses, represent major human health risks due to their highly contagious nature, the severity of the clinical manifestations induced, the lack of vaccines, and the very limited therapeutic options currently available. Appropriate animal models are obviously critical to study disease pathogenesis and develop efficient therapies. We recently reported that the clone 13 (Cl13) variant of the lymphocytic choriomeningitis virus (LCMV-Cl13), a prototype arenavirus closely related to Lassa virus, causes in some mouse strains endothelial damage, vascular leakage, platelet loss, and death, mimicking pathological aspects typically observed in Lassa and other HF syndromes...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28986247/the-reintroduction-of-denv-2-in-2011-in-panama-and-subsequent-outbreak-characteristic
#6
Yamilka Díaz, Julio Cisneros, Hilda Guzmán, Paola Cordoba, Jean-Paul Carrera, Brechla Moreno, Rubing Chen, Juan Castillo Mewa, Lourdes García, Lizbeth Cerezo, Amelia Travassos da Rosa, Nathan D Gundacker, Blas Armién, Scott C Weaver, Nikos Vasilakis, Sandra López-Vergès, Robert Tesh
The circulation of the South-east Asian/American (AS/AM) dengue 2 virus (DENV-2) genotype in the Americas has been associated with a high rate of severe disease. From 1993, the year DENV was reintroduced in Panama, until 2011 there were 29 dengue-associated deaths, 17 of which occurred in 2011, the most severe outbreak with a case fatality rate (CFR) of 44% (17 deaths out of 38 severe dengue cases). During this outbreak DENV-2 was reintroduced into the country, whereas over the prior five years DENV-1 and -3 were predominant...
October 3, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28977169/dengue-in-pregnant-women-characterization-of-cases-in-brazil-2007-2015
#7
Laura Branquinho do Nascimento, Cláudio Morais Siqueira, Giovanini Evelim Coelho, João Bosco Siqueira
OBJECTIVE: to characterize the probable cases of dengue in pregnant women reported in Brazil, from 2007 to 2015. METHODS: descriptive study of sociodemographic, epidemiological, clinical and laboratory characteristics, with data from the Information System for Notifiable Diseases (Sinan). RESULTS: the annual incidence of dengue in pregnant women ranged from 3.3 (2009) to 816.6 (2010) cases per 100 thousand live births; of the 43,772 probable cases of dengue in pregnant women, 81...
July 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/28973490/circulation-of-denv2-and-denv4-in-aedes-aegypti-diptera-culicidae-mosquitoes-from-praia-santiago-island-cabo-verde
#8
Duschinka R D Guedes, Elisete T B Gomes, Marcelo H S Paiva, Maria A V de Melo-Santos, Joana Alves, Lara F Gómez, Constância F J Ayres
Arthropod-borne viruses, such as Dengue (DENV), Chikungunya (CHIKV), and Zika (ZIKV), pose a challenge to public health, due to their worldwide distribution and large-scale outbreaks. Dengue fever is currently one of the most important diseases and it is caused by four serotypes of DENV and is mainly transmitted by the mosquito Aedes aegypti. It is estimated that 50-100 million cases are reported every year worldwide. More recently, CHIKV and ZIKV, which are also transmitted by Ae. aegypti, have caused epidemics in countries in the Caribbean region, the Pacific region, and Americas...
July 1, 2017: Journal of Insect Science
https://www.readbyqxmd.com/read/28964768/clinical-laboratory-and-demographic-determinants-of-hospitalization-due-to-dengue-in-7613-patients-a-retrospective-study-based-on-hierarchical-models
#9
Natal Santos da Silva, Eduardo A Undurraga, Elis Regina da Silva Ferreira, Cássia Fernanda Estofolete, Maurício Lacerda Nogueira
In Brazil, the incidence of hospitalization due to dengue, as an indicator of severity, has drastically increased since 1998. The objective of our study was to identify risk factors associated with subsequent hospitalization related to dengue. We analyzed 7613 dengue confirmed via serology (ELISA), non-structural protein 1, or polymerase chain reaction amplification. We used a hierarchical framework to generate a multivariate logistic regression based on a variety of risk variables. This was followed by multiple statistical analyses to assess hierarchical model accuracy, variance, goodness of fit, and whether or not this model reliably represented the population...
September 28, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28962968/dengue-fever-mortality-score-a-novel-decision-rule-to-predict-death-from-dengue-fever
#10
Chien-Cheng Huang, Chien-Chin Hsu, How-Ran Guo, Shih-Bin Su, Hung-Jung Lin
OBJECTIVES: Dengue fever (DF) is still a major challenge for public health, especially during massive outbreaks. We developed a novel prediction score to help decision making, which has not been performed till date. METHODS: We conducted a retrospective case-control study to recruit all the DF patients who visited a medical center during the 2015 DF outbreak. Demographic data, vital signs, symptoms/signs, chronic comorbidities, laboratory data, and 30-day mortality rates were included in the study...
September 27, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28957754/discovery-of-selective-dengue-virus-inhibitors-using-combination-of-molecular-fingerprint-based-virtual-screening-protocols-structure-based-pharmacophore-model-development-molecular-dynamics-simulations-and-in-vitro-studies
#11
Shaher Bano Mirza, Regina Ching Hua Lee, Justin Jang Hann Chu, Ramin Ekhteiari Salmas, Thomas Mavromoustakos, Serdar Durdagi
Dengue virus is a major issue of tropical and sub-tropical regions. The proliferation of virus results in immense number of deaths each year because of unavailability of on-shelf drugs. This issue necessitates the design of novel anti-Dengue drugs. The protease enzyme pathway is the critical target for drug design due to its significance in the replication, survival and other cellular activities of Dengue virus. Keeping in mind the worsening situation regarding Dengue virus, approximately eighteen million drug-like compounds from the ZINC small molecule database have been screened against Nonstructural Protein 3 (NS3) previously by our group...
August 9, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28941278/age-associated-differences-in-clinical-manifestations-and-laboratory-parameters-during-a-dengue-virus-type-4-outbreak-in-argentina
#12
Alana B Byrne, Guillermo F Gutierrez, Agostina Bruno, María Teresa Córdoba, María Manuela Bono, Fernando P Polack, Laura B Talarico, Marcelo O Quipildor
Infection by any of the four dengue virus (DENV) serotypes produces a wide spectrum of clinical illness in humans. Differences in clinical manifestation and severity have been associated with secondary heterologous infection, patient age and virus serotype. In this context, this retrospective study sought to analyze the presentation of dengue in patients during the 2014 DENV-4 outbreak affecting the City of Orán, Salta Province, Argentina. Demographic data, clinical manifestations and laboratory abnormalities of laboratory-confirmed dengue patients were compared between age groups and between patients with and without warning signs...
September 23, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28937986/household-costs-of-hospitalized-dengue-illness-in-semi-rural-thailand
#13
Yesim Tozan, Pitcha Ratanawong, Maquines Odhiambo Sewe, Annelies Wilder-Smith, Pattamaporn Kittayapong
BACKGROUND: Dengue-related illness is a leading cause of hospitalization and death in Thailand and other Southeast Asian countries, imposing a major economic burden on households, health systems, and governments. This study aims to assess the economic impact of hospitalized dengue cases on households in Chachoengsao province in eastern Thailand. METHODS: We conducted a prospective cost-of-illness study of hospitalized pediatric and adult dengue patients at three public hospitals...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28934991/the-dengue-preface-to-endemic-in-mainland-china-the-historical-largest-outbreak-by-aedes-albopictus-in-guangzhou-2014
#14
Lei Luo, Li-Yun Jiang, Xin-Cai Xiao, Biao Di, Qin-Long Jing, Sheng-Yong Wang, Jin-Ling Tang, Ming Wang, Xiao-Ping Tang, Zhi-Cong Yang
BACKGROUND: Dengue was regarded as a mild epidemic in mainland China transmitted by Aedes albopictus. However, the 2014 record-breaking outbreak in Guangzhou could change the situation. In order to provide an early warning of epidemic trends and provide evidence for prevention and control strategies, we seek to characterize the 2014 outbreak through application of detailed cases and entomological data, as well as phylogenetic analysis of viral envelope (E) gene. METHODS: We used case survey data identified through the Notifiable Infectious Disease Report System, entomological surveillance and population serosurvey, along with laboratory testing for IgM/IgG, NS1, and isolation of viral samples followed by E gene sequencing and phylogenetic analysis to examine the epidemiological and molecular characteristics of the outbreak...
September 22, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28932235/zika-virus-congenital-syndrome-experimental-models-and-clinical-aspects
#15
REVIEW
Carolina Manganeli Polonio, Carla Longo de Freitas, Nagela Ghabdan Zanluqui, Jean Pierre Schatzmann Peron
Viral infections have long been the cause of severe diseases to humans, increasing morbidity and mortality rates worldwide, either in rich or poor countries. Yellow fever virus, H1N1 virus, HIV, dengue virus, hepatitis B and C are well known threats to human health, being responsible for many million deaths annually, associated to a huge economic and social cost. In this context, a recently introduced flavivirus in South America, called Zika virus (ZIKV), led the WHO to declare in February 1st 2016 a warning on Public Health Emergency of International Concern (PHEIC)...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28930151/perk-signal-modulated-protein-translation-promotes-the-survivability-of-dengue-2-virus-infected-mosquito-cells-and-extends-viral-replication
#16
Jiun-Nan Hou, Tien-Huang Chen, Yi-Hsuan Chiang, Jing-Yun Peng, Tsong-Han Yang, Chih-Chieh Cheng, Eny Sofiyatun, Cheng-Hsun Chiu, Chuan Chiang-Ni, Wei-June Chen
Survival of mosquitoes from dengue virus (DENV) infection is a prerequisite of viral transmission to the host. This study aimed to see how mosquito cells can survive the infection during prosperous replication of the virus. In C6/36 cells, global protein translation was shut down after infection by DENV type 2 (DENV2). However, it returned to a normal level when infected cells were treated with an inhibitor of the protein kinase RNA (PKR)-like ER kinase (PERK) signaling pathway. Based on a 7-Methylguanosine 5'-triphosphate (m7GTP) pull-down assay, the eukaryotic translation initiation factor 4F (eIF4F) complex was also identified in DENV2-infected cells...
September 20, 2017: Viruses
https://www.readbyqxmd.com/read/28919592/the-study-on-the-lives-and-health-conditions-of-internees-in-santo-thomas-camp-of-philippines-based-on-mcanlis-s-the-war-in-manila-1941-1945
#17
Jueyeon Lee, Youngsoo Cho
When Japan invaded the Philippines, two missionary dentists (Dr. McAnlis and Dr. Boots) who were forced to leave Korea were captured and interned in the Santo Thomas camp in Manila. Japan continued to bombard and plunder the Philippines in the wake of the Pacific War following the Great East Asia policy, leading to serious inflation and material deficiency. More than 4,000 Allied citizens held in Santo Thomas camp without basic food and shelter. Santo Thomas Camp was equipped with the systems of the Japanese military medical officers and Western doctors of captivity based on the Geneva Conventions(1929)...
August 2017: Ŭi Sahak
https://www.readbyqxmd.com/read/28914200/development-of-peptide-vaccines-in-dengue
#18
Kavita Reginald, Yanqi Chan, Magdalena Plebanski, Chit Laa Poh
Dengue is one of the most important arboviral infection worldwide, infecting up to 390 million people and causing 25,000 deaths annually. Although a licensed dengue vaccine is available, it is not efficacious against dengue serotypes that infect people living in South East Asia, where dengue is an endemic disease. Hence, there is an urgent need to develop an efficient dengue vaccine for this region. Data from different clinical trials indicate that a successful dengue vaccine must elicit both neutralizing antibodies and cell mediated immunity...
September 13, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28906367/predicting-the-mortality-in-geriatric-patients-with-dengue-fever
#19
Hung-Sheng Huang, Chien-Chin Hsu, Je-Chiuan Ye, Shih-Bin Su, Chien-Cheng Huang, Hung-Jung Lin
Geriatric patients have high mortality for dengue fever (DF); however, there is no adequate method to predict mortality in geriatric patients. Therefore, we conducted this study to develop a tool in an attempt to address this issue.We conducted a retrospective case-control study in a tertiary medical center during the DF outbreak in Taiwan in 2015. All the geriatric patients (aged ≥65 years) who visited the study hospital between September 1, 2015, and December 31, 2015, were recruited into this study. Variables included demographic data, vital signs, symptoms and signs, comorbidities, living status, laboratory data, and 30-day mortality...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28903847/dengue-hemorrhagic-fever-arare-cause-of-acute-liver-failure
#20
Aisha Nazeer, Ayesha Aslam Rai, Nasir Hassan Luck, Abbas Ali Yousuf Tasneem
Acute liver failure (ALF) is an acute medical emergency which carries high mortality without liver transplantation. Various hepatotropic viruses, drug induced liver injury, auto immune hepatitis, and metabolic liver diseases are the commonly implicated etiologic agents. Liver involvement in dengue hemorrhagic fever (DHF) is quite common, but acute liver failure is its rare complication. Neurological complications are also commonly seen in DHF. Ateenage girl presented with high grade fever and subconjunctival hemorrhage, and later developed jaundice due to acute liver failure...
August 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
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