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JOURNAL ARTICLE
Saad Sammani, Tadeo Bermudez, Carrie L Kempf, Jin H Song, Justin C Fleming, Vivian Reyes Hernon, Matthew Hufford, Lin Tang, Hua Cai, Sara M Camp, Viswanathan Natarajan, Jeffrey R Jacobson, Steven M Dudek, Diego R Martin, Christof Karmonik, Xiaoguang Sun, Belinda Sun, Nancy G Casanova, Christian Bime, Joe G N Garcia
Background: Numerous potential ARDS therapeutics, based upon preclinical successful rodent studies that utilized LPS challenge without mechanical ventilation, have failed in Phase 2/3 clinical trials. Recently, ALT-100 mAb, a novel biologic that neutralizes the TLR4 ligand and DAMP, eNAMPT (extracellular nicotinamide phosphoribosyltransferase), was shown to reduce septic shock/VILI-induced porcine lung injury when delivered 2 h after injury onset. We now examine the ALT-100 mAb efficacy on acute kidney injury (AKI) and lung fluid balance in a porcine ARDS/VILI model when delivered 6 h post injury...
2022: Frontiers in Physiology
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JOURNAL ARTICLE
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June 2016: Annals of Intensive Care
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