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https://www.readbyqxmd.com/read/29055286/in-defense-of-progesterone-a-review-of-the-literature
#1
Allan Lieberman, Luke Curtis
Context • The medical literature on the use of progesterone in postmenopausal women is often confusing and contradictory. Some physicians implicate natural progesterone in an increase in the risk of breast cancer. The chemical structure of natural progesterone (P4) is quite different from chemically altered, synthetic chemicals called progestins, which results in different actions at the cell level. Objective • The research team intended to review the literature to examine the benefits and safety of natural progesterone and determine whether it can cause an increase or decrease in breast cancer risk...
October 21, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29055209/long-term-survival-of-sorafenib-treated-flt3-itd-positive-acute-myeloid-leukaemia-patients-relapsing%C3%A2-after-allogeneic-stem-cell-transplantation
#2
S K Metzelder, T Schroeder, M Lübbert, M Ditschkowski, K Götze, S Scholl, R G Meyer, P Dreger, N Basara, M F Fey, H R Salih, A Finck, T Pabst, A Giagounidis, G Kobbe, E Wollmer, J Finke, A Neubauer, A Burchert
BACKGROUND: Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD)-positive acute myeloid leukaemia (AML) relapsing after allogeneic stem cell transplantation (allo-SCT) has a dismal prognosis with limited therapeutic options. FLT3-ITD kinase inhibition is a reasonable but palliative experimental treatment alternative in this situation. Information on long-term outcome is not available. METHODS: We performed a long-term follow-up analysis of a previously reported cohort of 29 FLT3-ITD-positive AML patients, which were treated in relapse after allo-SCT with sorafenib monotherapy...
October 18, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29055169/diversification-in-tropics-and-subtropics-following-the-mid-miocene-climate-change-a-case-study-of-the-spider-genus-nesticella
#3
Francesco Ballarin, Shuqiang Li
Caves may offer suitable refugia for troglophilic invertebrates during periods of unfavourable climatic conditions because of their stable microclimates. As a consequence, allopatric divergence from their epigean counterparts may occur, leading to formation of truly hypogean communities (the Climatic Relict Hypothesis). Unlike the well-studied effects of Pleistocene glaciations, we know little about how ancient climate changes drove the development of cave-dwelling organisms living at both middle and lower latitudes...
October 21, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29055160/temperature-and-soil-fertility-as-regulators-of-tree-line-scots-pine-growth-and-survival-implications-for-the-acclimation-capacity-of-northern-populations
#4
Matti Rousi, Boy J M H Possen, Seppo Ruotsalainen, Tarja Silfver, Juha Mikola
The acclimation capacity of leading-edge tree populations is crucially important in a warming climate. Theoretical considerations suggest that adaptation through genetic change is needed, but this may be a slow process. Both positive and catastrophic outcomes have been predicted, while empirical studies have lagged behind theory development. Here we present results of a 30-year study of 55 000 Scots pine (Pinus sylvestris) trees, planted in 15 common gardens in three consecutive years near and beyond the present Scots pine tree line...
October 21, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29055147/cognitive-function-among-long-term-survivors-of-heart-transplantation
#5
Britta S Bürker, Einar Gude, Lars Gullestad, Ingelin Grov, Anne Relbo Authen, Arne K Andreassen, Odd E Havik, Mary Amanda Dew, Arnt E Fiane, Ira R Haraldsen, Ulrik F Malt, Stein Andersson
BACKGROUND: Cognitive impairment is documented early after heart transplantation (HTx), but we lack data on cognitive function beyond the fourth year posttransplant. Against the background of good long-term survival, this knowledge is necessary to improve clinical care throughout the entire posttransplant period. METHODS: We assessed cognitive function with a neuropsychological test battery in a sample of HTx recipients ≥16 years posttransplant. To improve clinical utility, we also applied adapted consensus criteria for Mild Cognitive Impairment (MCI)...
October 21, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29055116/inhaled-cryptococcus-neoformans-elicits-allergic-airway-inflammation-independent-of-nf%C3%AE%C2%BAb-signaling-in-lung-epithelial-cells
#6
Andrew J McDermott, Tyler A Tumey, Mingwei Huang, Christina M Hull, Bruce S Klein
Pulmonary challenge with the ubiquitous fungus Cryptococcus neoformans results in allergic airway inflammation (AAI) characterized by robust recruitment of eosinophils and T-cells producing type 2 cytokines to the lungs. Previous studies have demonstrated a critical role for NFκB activation within lung epithelial cells (LECs) in driving AAI in response to protein allergens, yet the role of LEC-intrinsic NFκB in promoting AAI following exposure to C. neoformans is poorly understood. To investigate the role of LEC-intrinsic NFκB in promoting AAI following C...
October 20, 2017: Immunology
https://www.readbyqxmd.com/read/29055114/sorafenib-response-in-hepatocellular-carcinoma-micrornas-as-tuning-forks-mirnas-as-regulators-of-sorafenib-response-in-hcc
#7
REVIEW
Shruthi Kanthaje, Ankita Makol, Anuradha Chakraborti
Hepatocellular carcinoma (HCC), the primary liver malignancy attributes towards the second foremost cause of cancer related mortality. The targeted chemotherapeutic agent, sorafenib is known to exhibit a statistically significant but limited overall survival advantage in advanced HCC. However, the individual patient response towards sorafenib varies drastically with most of them demonstrating stable disease (SD), few with partial response (PR) and very rare complete response (CR). Progressive disease (PD) despite the treatment has also been demonstrated in many patients indicating drug resistance...
October 20, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29055078/neoadjuvant-chemoradiation-for-non-metastatic-pancreatic-cancer-increases-margin-negative-and-node-negative-rates-at-resection
#8
Camille A Berriochoa, May Abdel-Wahab, Charles Marc Leyrer, Alok Khorana, R Matthew Walsh, Aryavarta M S Kumar
AIM: Preoperative chemoradiation for non-metastatic pancreatic cancer patients has been associated with improved outcomes; however, direct comparisons to adjuvant therapy are limited. METHODS: Single institution data were obtained for non-metastatic pancreatic cancer patients treated with concurrent chemoradiation +/- resection from 2011-2014. Univariate analyses were performed to evaluate clinical and pathologic outcomes. RESULTS: Fifty-two well matched patients met inclusion criteria (neoadjuvant chemoradiation = 21, adjuvant chemoradiation = 11, definitive = 20)...
October 20, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29055056/everolimus-in-advanced-progressive-well-differentiated-nonfunctional-neuroendocrine-tumors-radiant-4-lung-subgroup-analysis
#9
Nicola Fazio, Roberto Buzzoni, Gianfranco Delle Fave, Margot E Tesselaar, Edward Wolin, Eric Van Cutsem, Paolo Tomassetti, Jonathan Strosberg, Maurizio Voi, Lida Bubuteishvili Pacaud, Antonia Ridolfi, Fabian Herbst, Jiri Tomasek, Simron Singh, Marianne Pavel, Matthew H Kulke, Juan W Valle, James C Yao
In the phase 3, RADIANT-4 study, everolimus improved median progression-free survival (PFS) by 7.1 months in patients with advanced, progressive, well-differentiated (grade 1 or grade 2), nonfunctional lung or gastrointestinal neuroendocrine tumors (NETs) vs placebo (hazard ratio [HR], 0.48; 95% confidence interval [CI], 0.35-0.67; P < .00001). This exploratory analysis reports the outcomes of the subgroup of patients with lung NETs. In RADIANT-4, patients were randomized (2:1) to everolimus 10 mg/d or placebo, both with best supportive care...
October 21, 2017: Cancer Science
https://www.readbyqxmd.com/read/29055054/a-multicenter-prospective-evaluation-study-of-endoscopic-ultrasound-guided-hepaticogastrostomy-combined-with-antegrade-stenting-with-video
#10
Takeshi Ogura, Masayuki Kitano, Mamoru Takenaka, Atsushi Okuda, Kosuke Minaga, Kentaro Yamao, Yukitaka Yamashita, Keiichi Hatamaru, Chishio Noguchi, Yasuhiko Gotoh, Taira Kuroda, Tomoyuki Yokota, Hidefumi Nishikiori, Ryota Sagami, Kazuhide Higuchi, Yasutaka Chiba
OBJECTIVE: EUS-guided hepaticogastrostomy (EUS-HGS) is often indicated for advanced stage patients because it prevents the adverse events associated with EUS-HGS procedures, and provides long stent patency. EUS-guided antegrade stenting (AS) has been developed as an advanced technique. Thus, to prevent adverse events and achieve, long stent patency, EUS-AS combined with EUS-HGS (EUS-HGAS) has been reported. The aim of this study was to evaluate the technical feasibility and efficacy of EUS-HGAS in a multicenter, prospective study...
October 20, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29055050/an-evolutionary-framework-outlining-the-integration-of-individual-social-and-spatial-ecology
#11
REVIEW
Quinn M R Webber, Eric Vander Wal
1.Behaviour is the interface between an organism and its environment, and behavioural plasticity is important for organisms to cope with environmental change. Social behaviour is particularly important because sociality is a dynamic process, where environmental variation influences group dynamics and social plasticity can mediate resource acquisition. Heterogeneity in the ecological environment can therefore influence the social environment. The combination of the ecological and social environments may be interpreted collectively as the 'socioecological' environment', which could explain variation in fitness...
October 21, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/29055040/the-concise-guide-to-pharmacology-2017-18-g-protein-coupled-receptors
#12
Stephen Ph Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29055039/the-concise-guide-to-pharmacology-2017-18-other-ion-channels
#13
Stephen Ph Alexander, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29055038/the-concise-guide-to-pharmacology-2017-18-ligand-gated-ion-channels
#14
Stephen Ph Alexander, John A Peters, Eamonn Kelly, Neil V Marrion, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29055037/the-concise-guide-to-pharmacology-2017-18-overview
#15
Stephen Ph Alexander, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, O Peter Buneman, John A Cidlowski, Arthur Christopoulos, Anthony P Davenport, Doriano Fabbro, Michael Spedding, Jörg Striessnig, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29055036/the-concise-guide-to-pharmacology-2017-18-catalytic-receptors
#16
Stephen Ph Alexander, Doriano Fabbro, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29055035/the-concise-guide-to-pharmacology-2017-18-transporters
#17
Stephen Ph Alexander, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29055034/the-concise-guide-to-pharmacology-2017-18-enzymes
#18
Stephen Ph Alexander, Doriano Fabbro, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29055033/the-concise-guide-to-pharmacology-2017-18-voltage-gated-ion-channels
#19
Stephen Ph Alexander, Jörg Striessnig, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29055032/the-concise-guide-to-pharmacology-2017-18-nuclear-hormone-receptors
#20
Stephen Ph Alexander, John A Cidlowski, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
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