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https://www.readbyqxmd.com/read/29917332/comparing-first-line-treatment-patterns-and-clinical-outcomes-of-patients-with-pan-negative-advanced-non-squamous-non-small-cell-lung-cancer
#1
Haiyan Xu, Fei Xu, Wenjie Zhu, Jianming Ying, Yan Wang
BACKGROUND: Platinum-based chemotherapy is the standard first-line treatment for patients with advanced pan-negative non-squamous (non-Sq) non-small cell lung cancer (NSCLC). However, it is unknown which chemotherapy regimen confers the greatest benefit in such patients. This study explored which chemotherapy regimens were advantageous in non-Sq NSCLC patients. METHODS: A retrospective study was conducted on 114 patients with advanced non-Sq NSCLC using platinum-based chemotherapy in a first-line setting between January 2013 and December 2015...
June 19, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29917326/replacement-and-desmoplastic-histopathological-growth-patterns-a-pilot-study-of-prediction-of-outcome-in-patients-with-uveal-melanoma-liver-metastases
#2
Raymond Barnhill, Peter Vermeulen, Sofie Daelemans, Pieter-Jan van Dam, Sergio Roman-Roman, Vincent Servois, Ilse Hurbain, Sophie Gardrat, Graça Raposa, Nicolas André, Rémi Dendale, Gaëlle Pierron, Laurence Desjardins, Nathalie Cassoux, Sophie Piperno-Neumann, Pascale Mariani, Claire Lugassy
Up to 50% of uveal melanomas (UM) metastasize to the liver within 10 years of diagnosis, and these almost always prove rapidly fatal. Since histopathological growth patterns (HGP) of liver metastases of the replacement and desmoplastic type, particularly from colon and breast carcinoma, may import valuable biological and prognostic information, we have studied HGP in a series of 41 UM liver metastases originating from 41 patients from the period 2006-2017. Twenty patients underwent enucleation while 21 had radiation therapy...
June 19, 2018: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/29917320/efficacy-of-repeated-surgery-is-superior-to-that-of-non-surgery-for-recurrent-second-primary-lung-cancer-after-initial-operation-for-primary-lung-cancer
#3
Haitao Zhou, Xiaozheng Kang, Liang Dai, Wanpu Yan, Yongbo Yang, Yao Lin, Ke-Neng Chen
BACKGROUND: The current study aimed to determine the oncological efficacy and surgical safety of multiple pulmonary resections (MPRs) after prior curative surgery for local regional recurrent or second primary lung cancers. METHODS: All cases of lung cancer included in our prospective database between January 2000 and July 2015 were retrospectively reviewed. The oncological efficacy endpoints for synchronous and metachronous MPR were five-year overall survival (OS), disease-free survival (DFS), and progression-free survival (PFS) rates after the second surgery...
June 19, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29917319/intrapleural-combination-therapy-with-lobaplatin-and-erythromycin-for-non-small-cell-lung-cancer-mediated-malignant-pleural-effusion
#4
Lisheng Xu, Benjie Wang, Meimei Gao, Yan Zhang, Qian Qi, Tao Li, Caiyu Li, Aihua Wang, Yu Li
BACKGROUND: Malignant pleural effusion is a common complication of non-small cell lung cancer (NSCLC); however, treatment options remain limited. This study evaluated the safety and efficacy of sequential intrapleural therapy with lobaplatin and erythromycin for NSCLC-mediated malignant pleural effusion. METHODS: Fifty-six patients with NSCLC complicated with malignant pleural effusion were recruited for a prospective single-arm study from December 2014 to 2016; one patient dropped out...
June 19, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29917299/the-role-of-histone-deacetylase-1-in-distant-metastasis-of-pancreatic-ductal-cancer
#5
Go Shinke, Daisaku Yamada, Hidetoshi Eguchi, Yoshifumi Iwagami, Tadafumi Asaoka, Takehiro Noda, Hiroshi Wada, Koichi Kawamoto, Kunihito Gotoh, Shogo Kobayashi, Yutaka Takeda, Masahiro Tanemura, Masaki Mori, Yuichiro Doki
Current therapies for pancreatic ductal cancer (PDAC) do not sufficiently control distant metastasis. Thus, new therapeutic targets are urgently needed. Numerous studies have suggested that the epithelial-mesenchymal transition (EMT) is pivotal for metastasis of carcinomas. The fact that the EMT is reversible suggests the possibility that it is induced by an epigenetic mechanism. In this study, we aimed to investigate the role of histone deacetylase 1 (HDAC1), which is an epigenetic mechanism on distant metastasis of PDAC...
June 19, 2018: Cancer Science
https://www.readbyqxmd.com/read/29917262/clinicopathological-analysis-of-oral-plasmablastic-lymphoma-a-systematic-review
#6
Carla Isabelly Rodrigues-Fernandes, Lucas Lacerda de Souza, Sara Ferreira Dos Santos Costa, André Myller Barbosa Silva, Hélder Antônio Rebelo Pontes, Márcio Ajudarte Lopes, Oslei Paes de Almeida, Peter A Brennan, Felipe Paiva Fonseca
BACKGROUND: Plasmablastic lymphoma (PBL) is a high grade lymphoma that often affects the oral cavity of HIV-positive patients; however, its prognostic determinants remain unknown. PURPOSE: To integrate the available data on oral PBL to determine its clinico-pathological features and to identify potential prognostic factors. METHODS: An electronic systematic review was performed using multiple databases with a specific search strategy in February 2018...
June 19, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29917194/long-non-coding-ran-zfas1-promotes-nasopharyngeal-carcinoma-through-activation-of-wnt-%C3%AE-catenin-pathway
#7
X Chen, J Li, C-L Li, X Lu
OBJECTIVE: To investigate the expression characteristics of long non-coding RNA (lncRNA) ZFAS1 in nasopharyngeal carcinoma (NPC) and to further investigate the role and mechanism of ZFAS1 in the occurrence and development of NPC. PATIENTS AND METHODS: 76 surgical excision samples from newly diagnosed NPC patients and 76 cases of paracancerous tissues were selected. The expression of ZFAS1 was detected by qRT-PCR (quantitative real-time polymerase chain reaction), and the relationship between the expression of ZFAS1 and the clinical prognosis of patients with NPC was analyzed...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917192/mir-4299-suppresses-non-small-cell-lung-cancer-cell-proliferation-migration-and-invasion-through-modulating-pten-akt-pi3k-pathway
#8
W-B Yang, W-P Zhang, J-L Shi, J-W Wang
OBJECTIVE: The aim of the present study was to investigate clinical significances and biological roles of miR-4299 in non-small cell lung cancer (NSCLC) PATIENTS AND METHODS: Expression of miR-4299 in NSCLC tissues and matched non-tumor tissues was determined by quantitative real-time PCR (qRT-PCR). The correlations between miR-4299 expression and clinicopathological characteristics and prognosis were also analyzed. MTT assay and Transwell assay were performed to determine the proliferation, migration and invasion...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917190/correlations-of-serum-vegf-and-mmp-2-levels-with-clm-in-crc-patients-and-effects-of-tace-on-their-expressions
#9
H Xu, Y-J Ren, K Liu, X-L Min, L Yang, Y Zhou, J Zheng, C Yang
OBJECTIVE: To investigate the correlations of serum vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) levels with colorectal liver metastasis (CLM) in patients with colorectal cancer (CRC), and determine the effects of transhepatic arterial chemoembolization (TACE) on their expressions. PATIENTS AND METHODS: A total of 110 CRC patients treated in the department of interventional radiology of our hospital from May 2013 to May 2016 were randomly enrolled...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917189/expressions-and-correlation-analysis-of-hif-1%C3%AE-survivin-and-vegf-in-patients-with-hepatocarcinoma
#10
Q-G Tian, Y-T Wu, Y Liu, J Zhang, Z-Q Song, W-F Gao, T-K Guo, C-H He, F-R Dai
OBJECTIVE: To investigate the expressions of HIF-1α, surviving, and VEGF in patients with hepatocarcinoma as well as the correlation analysis among them. PATIENTS AND METHODS: 65 patients, who were admitted to our hospital and diagnosed as hepatocarcinoma from January 2014 to October 2015, were selected as hepatocarcinoma group, while 50 healthy cases that do not have hepatocarcinoma were selected as normal control group. The expression levels of HIF-1α, surviving, and VEGF in hepatocarcinoma tissues of hepatocarcinoma group and normal liver tissues of control group were detected by immunohistochemical (SP) staining method; then, the correlation among them was explored...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917188/mechanism-of-lncrna-duxap8-in-promoting-proliferation-of-bladder-cancer-cells-by-regulating-pten
#11
M-G Lin, Y-K Hong, Y Zhang, B-B Lin, X-J He
OBJECTIVE: To evaluate the lncRNA DUXAP8 expression in bladder cancer and its mechanism. PATIENTS AND METHODS: Clinical specimens were analyzed. The expression of lncRNA in bladder cancer and adjacent tissues was detected using qRT-PCR. The χ2-test analysis was used to analyze the relationship between lncRNA DUXAP8 expression and clinicopathological information in patients with bladder cancer. The tumor cell activity and cell proliferation were measured by cell counting kit-8 (CCK8) and colony formation assay...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917186/long-non-coding-rna-fezf1-as1-is-up-regulated-and-associated-with-poor-prognosis-in-patients-with-cervical-cancer
#12
H-H Zhang, A-H Li
OBJECTIVE: Long noncoding RNA FEZF1-AS1 (FEZF1-AS1) has been showed to involve in a variety of cancers. However, its function and clinical significance in cervical cancer (CC) have not been investigated. The aim of this study was to explore the prognostic value of FEZF1-AS1 in CC patients. PATIENTS AND METHODS: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to determine the expression level of FEZF1-AS1 in CC specimens and adjacent normal cervical tissues...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917185/microrna-212-participates-in-the-development-of-prostate-cancer-by-upregulating-bmi1-via-nf-%C3%AE%C2%BAb-pathway
#13
H-W Qu, Y Jin, Z-L Cui, X-B Jin
OBJECTIVE: To investigate the role of microRNA-212 in prostate cancer (PCa) and its underlying mechanism. PATIENTS AND METHODS: MicroRNA-212 expressions in 72 PCa tissues and paracancerous tissues were detected by qRT-PCR (quantitative real-time polymerase chain reaction). The relationship between microRNA-212 expression and clinical characteristics of PCa patients was analyzed. Target genes of microRNA-212 were predicted by TargetScan and verified by luciferase reporter gene assay...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917184/long-noncoding-rna-snhg5-is-up-regulated-and-serves-as-a-potential-prognostic-biomarker-in-acute-myeloid-leukemia
#14
J Li, C-K Sun
OBJECTIVE: Growing evidence has demonstrated that the dysregulation of long non-coding RNAs (lncRNAs) may act as an important role in human tumorigenesis. Our present study aimed to explore the expression pattern and prognostic value of a newly discovered lncRNA small nucleolar RNA host gene 5 (SNHG5) in acute myeloid leukemia (AML). PATIENTS AND METHODS: The expression of SNHG5 was determined using Real-time reverse transcription-polymerase chain reaction (qRT-PCR) in bone marrow and plasma obtained from AML patients and healthy controls...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917183/mir-143-regulates-proliferation-and-apoptosis-of-myelocytic-leukemia-cell-hl-60-via-modulating-erk1
#15
B Song, Y-J Tang, W-G Zhang, C-C Wan, Y Chen, L-J Zhang
OBJECTIVE: Extracellular signal-regulated kinase (ERK)/mitogen activated protein kinase (MAPK) signaling pathway is widely involved in cell proliferation and invasion regulation. Enhanced expression or function of ERK1 is important for leukemia. Abnormal down-regulation of microRNA (miR)-143 is correlated with leukemia pathogenesis, indicating possible tumor-suppressing role. Bioinformatics analysis showed the existence of complementary binding sites between miR-143 and ERK1. This study aims to investigate whether the miR-143 plays a role in mediating ERK1 expression and proliferation and apoptosis of leukemia cells...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917167/androgen-receptor-induces-epha3-expression-by-interacting-with-transcription-factor-sp1
#16
Xiaowei Diao, Xiubin Chen, Yurui Pi, Yu Zhang, Fangfang Wang, Ping Liu, Yanhong Gao, Xiaojun Wang, Sijun Yang, Shan Lu
Erythropoietin‑producing hepatocellular carcinoma cell surface type‑A receptor 3 (EPHA3) has been found to promote the proliferation and survival of prostate cancer (PCa) cell lines and prostate tumor development in nude mice. However, the regulation of EPHA3 in PCa remains largely unknown. This study is aimed to investigate the association between EPHA3 expression and androgen receptor (AR) signaling and the potential mechanism. We determined mRNA and protein levels of EPHA3 and AR signaling‑related genes in the PCa cell line 22Rv1 by reverse transcription‑polymerase chain reaction (RT‑PCR) and western blotting, respectively...
June 18, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29917140/predictive-biomarkers-for-endocrine-therapy-retrospective-study-in-tamoxifen-and-exemestane-adjuvant-multinational-team-trial
#17
Antonia K Roseweir, Lindsay Bennett, Ashley Dickson, Kelvin Cheng, Mary-Anne Quintayo, Jane Bayani, Donald C McMillan, Paul G Horgan, Cornelis J H van de Velde, Caroline Seynaeve, Annette Hasenburg, Dirk G Kieback, Christos Markopoulos, Luc Y Dirix, Daniel W Rea, Elizabeth A Mallon, John M S Bartlett, Joanne Edwards
Background: Aromatase inhibitors improve disease-free survival compared with tamoxifen in postmenopausal women with hormone receptor-positive breast cancer. The Tamoxifen and Exemestane Adjuvant Multinational (TEAM) trial compared exemestane monotherapy with sequential therapy of tamoxifen followed by exemestane. The trial failed to show a statistically significant difference between treatment arms. A robust translational program was established to investigate predictive biomarkers. Methods: A tissue microarray was retrospectively constructed using a subset of patient tissues (n = 4631) from the TEAM trial (n = 9766)...
June 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29917116/pediatric-supratentorial-ependymoma-surgical-clinical-and-molecular-analysis
#18
Jock C Lillard, Garrett T Venable, Nickalus R Khan, Ruth G Tatevossian, James Dalton, Brandy N Vaughn, Paul Klimo
BACKGROUND: Pediatric supratentorial ependymomas (SEs) have distinct molecular and behavioral differences from their infratentorial counterparts. OBJECTIVE: To present our experience with pediatric SEs over a 24-yr period. METHODS: Clinical, operative, and radiographic information was abstracted retrospectively. Our primary outcomes were progression-free survival (PFS) and overall survival (OS). Detection of C11orf95-RELA rearrangement was performed using interphase fluorescence in situ hybridization (iFISH)...
June 16, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29916965/spontaneous-pneumomediastinum-in-connective-tissue-diseases
#19
Federica De Giacomi, Misbah Baqir, Christian W Cox, Teng Moua, Eric L Matteson, Jay H Ryu
BACKGROUND: Spontaneous pneumomediastinum (SP) is an uncommon disorder but has been described in cases with connective tissue diseases (CTDs), most commonly dermatomyositis and polymyositis. We aimed to explore this relationship by analyzing the characteristics of CTD patients with SP. METHODS: Using a computer-assisted search, we identified 25 patients with CTD and SP evaluated between January 1997 and December 2016 at our institution. Clinicoradiologic characteristics, treatment, and outcomes were extracted and chest computed tomography studies analyzed...
June 18, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29916930/development-of-predictive-algorithms-for-pre-treatment-motor-deficit-and-90-day-mortality-in-spinal-epidural-abscess
#20
Akash A Shah, Paul T Ogink, Mitchel B Harris, Joseph H Schwab
BACKGROUND: Spinal epidural abscess is a high-risk condition that can lead to paralysis or death. It would be of clinical and prognostic utility to identify which subset of patients with spinal epidural abscess is likely to develop a motor deficit or die within 90 days of discharge. METHODS: We identified all patients ≥18 years of age who were admitted to our hospital system with a diagnosis of spinal epidural abscess during the period of 1993 to 2016. Explanatory variables were collected retrospectively...
June 20, 2018: Journal of Bone and Joint Surgery. American Volume
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