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JOURNAL ARTICLE
Kaytlin Krutsch, Levi Campbell, Teresa Baker, Palika Datta
PURPOSE: Buspirone, an anxiolytic with minimal risk of dependence or respiratory depression, lacks extensive published data on its transfer into human milk during lactation. The objective of this study was to 1) quantify the transfer of buspirone and its active metabolite 1-pyrimidinylpiperazine (1-PP) into human milk, allowing for an estimation of maternal drug exposure to the breastfed infant, and 2) report observations of the infants exposed to buspirone via breastmilk. METHODS: Milk samples and health histories were collected from nine lactating mothers who donated milk samples to the InfantRisk Human Milk Biorepository while taking buspirone...
February 20, 2024: Archives of Women's Mental Health
#22
JOURNAL ARTICLE
Isabella Peixoto de Barcelos, Sarah Woidill, Francesco Gavazzi, Nicholson B Modesti, Anjana Sevagamoorthy, Adeline Vanderver, Laura Adang
OBJECTIVE: Aicardi Goutières Syndrome (AGS) is a genetic interferonopathy associated with multisystemic heterogeneous disease and neurologic dysfunction. AGS includes a broad phenotypic spectrum which is only partially explained by genotype. To better characterize this variability, we will perform a systematic analysis of phenotypic variability in familial cases of AGS. METHODS: Among thirteen families, twenty-six siblings diagnosed with AGS were identified from the Myelin Disorders and Biorepository Project (MDBP) at the Children's Hospital of Philadelphia...
February 13, 2024: Molecular Genetics and Metabolism
#23
REVIEW
Lisa P Jacobson, Corette B Parker, David Cella, Daniel K Mroczek, Barry M Lester
The United States (U.S.) National Institutes of Health-funded Environmental influences on Child Health Outcomes (ECHO)-wide Cohort was established to conduct high impact, transdisciplinary science to improve child health and development. The cohort is a collaborative research design in which both extant and new data are contributed by over 57,000 children across 69 cohorts. In this review article, we focus on two key challenging issues in the ECHO-wide Cohort: data collection standardization and data harmonization...
February 16, 2024: Pediatric Research
#24
JOURNAL ARTICLE
Matthew J Mosgrove, Ritu Sachdeva, Kayla L Stratton, Saro H Armenian, Aarti Bhat, Kasey J Leger, Christina Yang, Wendy M Leisenring, Lillian R Meacham, Karim T Sadak, Shanti L Narasimhan, Paul C Nathan, Eric J Chow, William L Border
BACKGROUND: A previous multicenter study showed that longitudinal changes in standard cardiac functional parameters were associated with the development of cardiomyopathy in childhood cancer survivors (CCS). Evaluation of the relationship between global longitudinal strain (GLS) changes and cardiomyopathy risk was limited, largely due to lack of quality apical 2- and 3-chamber views in addition to 4-chamber view. We sought to determine whether apical 4-chamber longitudinal strain (A4LS) alone can serve as a suitable surrogate for GLS in this population...
February 2024: Echocardiography
#25
JOURNAL ARTICLE
Christopher C Witt, Chauncey R Gadek, Jean-Luc E Cartron, Michael J Andersen, Mariel L Campbell, Marialejandra Castro-Farías, Ethan F Gyllenhaal, Andrew B Johnson, Jason L Malaney, Kyana N Montoya, Andrew Patterson, Nicholas T Vinciguerra, Jessie L Williamson, Joseph A Cook, Jonathan L Dunnum
Per- and polyfluoroalkyl substances (PFAS) in the environment pose persistent and complex threats to human and wildlife health. Around the world, PFAS point sources such as military bases expose thousands of populations of wildlife and game species, with potentially far-reaching implications for population and ecosystem health. But few studies shed light on the extent to which PFAS permeate food webs, particularly ecologically and taxonomically diverse communities of primary and secondary consumers. Here we conducted >2000 assays to measure tissue-concentrations of 17 PFAS in 23 species of mammals and migratory birds at Holloman Air Force Base (AFB), New Mexico, USA, where wastewater catchment lakes form biodiverse oases...
February 5, 2024: Environmental Research
#26
REVIEW
Sandra Perdomo, Behnoush Abedi-Ardekani, Ana Carolina de Carvalho, Aida Ferreiro-Iglesias, Valérie Gaborieau, Thomas Cattiaux, Hélène Renard, Priscilia Chopard, Christine Carreira, Andreea Spanu, Arash Nikmanesh, Ricardo Cortez Cardoso Penha, Samuel O Antwi, Patricia Ashton-Prolla, Cristina Canova, Taned Chitapanarux, Riley Cox, Maria Paula Curado, José Carlos de Oliveira, Charles Dzamalala, Elenora Fabianova, Lorenzo Ferri, Rebecca Fitzgerald, Lenka Foretova, Steven Gallinger, Alisa M Goldstein, Ivana Holcatova, Antonio Huertas, Vladimir Janout, Sonata Jarmalaite, Radka Kaneva, Luiz Paulo Kowalski, Tomislav Kulis, Pagona Lagiou, Jolanta Lissowska, Reza Malekzadeh, Dana Mates, Valerie McCorrmack, Diana Menya, Sharayu Mhatre, Blandina Theophil Mmbaga, André de Moricz, Péter Nyirády, Miodrag Ognjanovic, Kyriaki Papadopoulou, Jerry Polesel, Mark P Purdue, Stefan Rascu, Lidia Maria Rebolho Batista, Rui Manuel Reis, Luis Felipe Ribeiro Pinto, Paula A Rodríguez-Urrego, Surasak Sangkhathat, Suleeporn Sangrajrang, Tatsuhiro Shibata, Eduard Stakhovsky, Beata Świątkowska, Carlos Vaccaro, Jose Roberto Vasconcelos de Podesta, Naveen S Vasudev, Marta Vilensky, Jonathan Yeung, David Zaridze, Kazem Zendehdel, Ghislaine Scelo, Estelle Chanudet, Jingwei Wang, Stephen Fitzgerald, Calli Latimer, Sarah Moody, Laura Humphreys, Ludmil B Alexandrov, Michael R Stratton, Paul Brennan
Large-scale biorepositories and databases are essential to generate equitable, effective, and sustainable advances in cancer prevention, early detection, cancer therapy, cancer care, and surveillance. The Mutographs project has created a large genomic dataset and biorepository of over 7,800 cancer cases from 30 countries across five continents with extensive demographic, lifestyle, environmental, and clinical information. Whole-genome sequencing is being finalized for over 4,000 cases, with the primary goal of understanding the causes of cancer at eight anatomic sites...
January 31, 2024: Cell Genom
#27
JOURNAL ARTICLE
Alfredo Quiñones-Hinojosa, Aleeshba Basil, Diogo Moniz-Garcia, Paola Suarez-Meade, Andres Ramos, Mark Jentoft, Erik Middlebrooks, Sanjeet Grewal, Kingsley Abode-Iyamah, Mohamad Bydon, Jann Sarkaria, Dennis Dickson, Kristin Swanson, Steven Rosenfeld, Paula Schiapparelli, Hugo Guerrero-Cazares, Kaisorn Chaichana, Fredric Meyer
OBJECTIVE: To establish a neurologic disorder-driven biospecimen repository to bridge the operating room with the basic science laboratory and to generate a feedback cycle of increased institutional and national collaborations, federal funding, and human clinical trials. METHODS: Patients were prospectively enrolled from April 2017 to July 2022. Tissue, blood, cerebrospinal fluid, bone marrow aspirate, and adipose tissue were collected whenever surgically safe. Detailed clinical, imaging, and surgical information was collected...
February 2024: Mayo Clinic Proceedings
#28
EDITORIAL
Richard G Ellenbogen
No abstract text is available yet for this article.
February 2024: Mayo Clinic Proceedings
#29
JOURNAL ARTICLE
Christopher W Seymour, Kelly Lynn Urbanek, Anna Nakayama, Jason N Kennedy, Rachel Powell, Renã A S Robinson, Kathryn L Kapp, Timothy R Billiar, Yoram Vodovotz, Stacy L Gelhaus, Vaughn S Cooper, Lu Tang, Flo Mayr, Katherine M Reitz, Christopher Horvat, Nuala J Meyer, Robert P Dickson, Derek Angus, Octavia Peck Palmer
BACKGROUND: Sepsis is a common and deadly syndrome, accounting for more than 11 million deaths annually. To mature a deeper understanding of the host and pathogen mechanisms contributing to poor outcomes in sepsis, and thereby possibly inform new therapeutic targets, sophisticated, and expensive biorepositories are typically required. We propose that remnant biospecimens are an alternative for mechanistic sepsis research, although the viability and scientific value of such remnants are unknown...
November 2023: Critical care explorations
#30
JOURNAL ARTICLE
Scott V Nguyen, Nikhita P Puthuveetil, Joseph R Petrone, Jade L Kirkland, Kaitlyn Gaffney, Corina L Tabron, Noah Wax, James Duncan, Stephen King, Robert Marlow, Amy L Reese, David A Yarmosh, Hannah H McConnell, Ana S Fernandes, John Bagnoli, Briana Benton, Jonathan L Jacobs
The ATCC Genome Portal (AGP, https://genomes.atcc.org/) is a database of authenticated genomes for bacteria, fungi, protists, and viruses held in ATCC's biorepository. It now includes 3,938 assemblies (253% increase) produced under ISO 9000 by ATCC. Here, we present new features and content added to the AGP for the research community.
January 30, 2024: Microbiology Resource Announcements
#31
JOURNAL ARTICLE
Shimon Kurasawa, Sawako Kato, Takaya Ozeki, Shin'ichi Akiyama, Takuji Ishimoto, Masashi Mizuno, Naotake Tsuboi, Noritoshi Kato, Tomoki Kosugi, Shoichi Maruyama
INTRODUCTION: Disease subtyping and monitoring are essential for the management of nephrotic syndrome (NS). Although various biomarkers for NS have been reported, their clinical efficacy has not been comprehensively validated in adult Japanese patients. METHODS: The Japanese Biomarkers in Nephrotic Syndrome (J-MARINE) study is a nationwide, multicenter, and prospective cohort study in Japan, enrolling adult (≥18 years) patients with minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), membranoproliferative glomerulonephritis (MPGN), C3 glomerulopathy (C3G), and lupus nephritis (LN)...
January 25, 2024: Clinical and Experimental Nephrology
#32
JOURNAL ARTICLE
Erin E Masterson, Jessica M Gavin
PURPOSE: The International PANS Registry (IPR) Epidemiology Study is a registry-based, longitudinal study. We designed this study to improve phenotyping and characterisation of children with paediatric acute-onset neuropsychiatric syndrome (PANS) and PANS-like features and facilitate multidisciplinary and translational health research. This cohort provides new opportunities to address unresolved research questions related to the broad spectrum of heterogenous PANS-like conditions. PARTICIPANTS: Inclusion in the IPR Epidemiology Study remains open indefinitely via IPR enrolment online...
January 24, 2024: BMJ Open
#33
JOURNAL ARTICLE
Dorothy Hui Lin Ng, Travis Ren Teen Chia, Barnaby Edward Young, Sapna Sadarangani, Ser Hon Puah, Jenny Guek Hong Low, Gabriel Zherong Yan, Yin Mo, Nicholas Jinghao Ngiam, Samuel Sherng Young Wang, Yan Tong Loo, Faith Evangeline Jie Qi Ong, Andrew Yunkai Li, Sharlene Ho, Lisa Ng, Paul Anantharajah Tambyah, Tsin Wen Yeo
BACKGROUND: Community-acquired respiratory infections are a leading cause of illness and death globally. The aetiologies of community-acquired pneumonia remain poorly defined. The RESPIRO study is an ongoing prospective observational cohort study aimed at developing pragmatic logistical and analytic platforms to accurately identify the causes of moderate-to-severe community-acquired pneumonia in adults and understand the factors influencing disease caused by individual pathogens. The study is currently underway in Singapore and has plans for expansion into the broader region...
January 23, 2024: BMC Infectious Diseases
#34
JOURNAL ARTICLE
Harry L Hébert, Mathilde M V Pascal, Blair H Smith, David Wynick, David L H Bennett
Chronic pain (CP) is a common and often debilitating disorder that has major social and economic impacts. A subset of patients develop CP that significantly interferes with their activities of daily living and requires a high level of healthcare support. The challenge for treating physicians is in preventing the onset of refractory CP or effectively managing existing pain. To be able to do this, it is necessary to understand the risk factors, both genetic and environmental, for the onset of CP and response to treatment, as well as the pathogenesis of the disorder, which is highly heterogenous...
September 2023: Pain Reports
#35
JOURNAL ARTICLE
Paris S Salazar-Hamm, William L Johnson, Robert A Nofchissey, Jacqueline R Salazar, Publio Gonzalez, Samuel M Goodfellow, Jonathan L Dunnum, Steven B Bradfute, Blas Armién, Joseph A Cook, Daryl B Domman, Darrell L Dinwiddie
BACKGROUND: Hantaviruses are negative-stranded RNA viruses that can sometimes cause severe disease in humans; however, they are maintained in mammalian host populations without causing harm. In Panama, sigmodontine rodents serve as hosts to transmissible hantaviruses. Due to natural and anthropogenic forces, these rodent populations are having increased contact with humans. METHODS: We extracted RNA and performed Illumina deep metatranscriptomic sequencing on Orthohantavirus seropositive museum tissues from rodents...
January 12, 2024: PLoS Neglected Tropical Diseases
#36
JOURNAL ARTICLE
Andrea B Troxel, Marie-Abele C Bind, Thomas J Flotte, Carlos Cordon-Cardo, Lauren A Decker, Aloke V Finn, Robert F Padera, R Ross Reichard, James R Stone, Natalie L Adolphi, Faye Victoria C Casimero, John F Crary, Jamie Elifritz, Arline Faustin, Saikat Kumar B Ghosh, Amanda Krausert, Maria Martinez-Lage, Jonathan Melamed, Roger A Mitchell, Barbara A Sampson, Alan C Seifert, Aylin Simsir, Cheryle Adams, Stephanie Haasnoot, Stephanie Hafner, Michelle A Siciliano, Brittany B Vallejos, Phoebe Del Boccio, Michelle F Lamendola-Essel, Chloe E Young, Deepshikha Kewlani, Precious A Akinbo, Brendan Parent, Alicia Chung, Teresa C Cato, Praveen C Mudumbi, Shari Esquenazi-Karonika, Marion J Wood, James Chan, Jonathan Monteiro, Daniel J Shinnick, Tanayott Thaweethai, Amber N Nguyen, Megan L Fitzgerald, Alice A Perlowski, Lauren E Stiles, Moira L Paskett, Stuart D Katz, Andrea S Foulkes
IMPORTANCE: SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or organ dysfunction after the acute phase of infection, termed Post-Acute Sequelae of SARS-CoV-2 (PASC), or long COVID. The characteristics, prevalence, trajectory and mechanisms of PASC are poorly understood. The objectives of the Researching COVID to Enhance Recovery (RECOVER) tissue pathology study (RECOVER-Pathology) are to: (1) characterize prevalence and types of organ injury/disease and pathology occurring with PASC; (2) characterize the association of pathologic findings with clinical and other characteristics; (3) define the pathophysiology and mechanisms of PASC, and possible mediation via viral persistence; and (4) establish a post-mortem tissue biobank and post-mortem brain imaging biorepository...
2024: PloS One
#37
JOURNAL ARTICLE
Graham McLennan, Suzanne E Dale, Laura Gillim, Vivian Weinblatt, Robert Wallerstein, Stanley J Naides
Lyme disease in pregnancy is understudied. The few available reports of Borrelia infection during pregnancy collecting clinical outcomes, with or without confirmed fetal infection both in utero and neonatal, are limited to case reports and small series. Population-based studies are not available. We propose a prospective study of Borrelia infection during pregnancy based in obstetrical practices in both endemic and nonendemic areas, with long term follow-up of pregnancy outcomes and development assessment of offspring infected or exposed to Borrelia in utero using current serological, microscopic, culture, and molecular techniques...
2024: Methods in Molecular Biology
#38
JOURNAL ARTICLE
Stanley J Naides
Availability of relevant biological samples supports both basic science research and patient-centered clinical studies. Establishing a biorepository faces challenges at multiple levels. These tasks include defining mission definition and scope; selection of subjects and sample types; recruitment strategies; timing of collection in the patient's journey; sample logistics and processing; determining what clinical data to collect; ensuring sample integrity on transport, processing, and storage; defining governance structures and oversight responsibilities; clarifying sample provenance and ownership; establishing procedures for sample and data access; selecting testing to be performed routinely versus upon request, and management of results; data security; funding sources; and regulatory compliance...
2024: Methods in Molecular Biology
#39
JOURNAL ARTICLE
Alexandre How-Kit, Mourad Sahbatou, Lise M Hardy, Nicolas P Tessier, Valérie Schiavon, Hélène Le Buanec, Jean-Marc Sebaoun, Hélène Blanché, Jean-François Zagury, Jean-François Deleuze
The increasing aging of the human population is currently and for the coming decades a major public health issue in many countries, requiring the implementation of global public health policies promoting healthy and successful aging. Individuals are not equal in the face of aging and some can present exceptional healthspan and/or lifespan, which are notably influenced by both genetic and environmental factors. Research and studies on human aging, healthy aging and longevity should rely in particular on cohorts of long-lived individuals, also including biological samples allowing studies on the biology of aging and longevity...
December 23, 2023: GeroScience
#40
JOURNAL ARTICLE
Harvey D Blackburn, Emmanuel Lozada-Soto, Samuel R Paiva
National animal gene banks have acquired substantial quantities of germplasm that protect and preserve a wide range of livestock breeds. New challenges and growth opportunities are emerging. A key challenge will be increased gene bank use, but this requires increased characterization of phenotypes and genotypes for populations and collections.
December 22, 2023: Trends in Genetics: TIG
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