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https://www.readbyqxmd.com/read/29141327/-gender-differences-in-stressful-life-events-and-depression-in-chinese-adults-aged-30-79-years
#1
M Wu, J C Li, C Q Yu, Y P Chen, J Lyu, Y Guo, Z Bian, Y L Tan, P Pei, J S Chen, Z M Chen, L M Li
Objective: To investigate gender specific differences in the association between stressful life events (SLEs) and depression in Chinese adults aged 30-79 years. Methods: In the baseline survey during 2004-2008, the China Kadoorie Biobank (CKB) recruited 512 891 men and women aged 30-79 years from 10 areas of China. Detailed information on SLEs, including demographic and socio-economic status, smoking, alcohol drinking and history of chronic disease, as well as depression symptoms and major depressive episodes (MDEs) in preceding 12 months, was collected by using standardized questionnaire...
November 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29141072/association-of-cetp-gene-variants-with-risk-for-vascular-and-nonvascular-diseases-among-chinese-adults
#2
Iona Y Millwood, Derrick A Bennett, Michael V Holmes, Ruth Boxall, Yu Guo, Zheng Bian, Ling Yang, Sam Sansome, Yiping Chen, Huaidong Du, Canqing Yu, Alex Hacker, Dermot F Reilly, Yunlong Tan, Michael R Hill, Junshi Chen, Richard Peto, Hongbing Shen, Rory Collins, Robert Clarke, Liming Li, Robin G Walters, Zhengming Chen
Importance: Increasing levels of high-density lipoprotein (HDL) cholesterol through pharmacologic inhibition of cholesteryl ester transfer protein (CETP) is a potentially important strategy for prevention and treatment of cardiovascular disease (CVD). Objective: To use genetic variants in the CETP gene to assess potential risks and benefits of lifelong lower CETP activity on CVD and other outcomes. Design, Setting, and Participants: This prospective biobank study included 151 217 individuals aged 30 to 79 years who were enrolled from 5 urban and 5 rural areas of China from June 25, 2004, through July 15, 2008...
November 15, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29136454/immediate-label-free-ex-vivo-evaluation-of-human-brain-tumor-biopsies-with-confocal-reflectance-microscopy
#3
Jennifer M Eschbacher, Joseph F Georges, Evgenii Belykh, Mohammedhassan Izady Yazdanabadi, Nikolay L Martirosyan, Emily Szeto, Catherine Y Seiler, Michael A Mooney, Jessica K Daniels, Katherine Y Goehring, Kendall R Van Keuren-Jensen, Mark C Preul, Stephen W Coons, Shwetal Mehta, Peter Nakaji
Confocal microscopy utilizing fluorescent dyes is widely gaining use in the clinical setting as a diagnostic tool. Reflectance confocal microscopy is a method of visualizing tissue specimens without fluorescent dyes while relying on the natural refractile properties of cellular and subcellular structures. We prospectively evaluated 76 CNS lesions with confocal reflectance microscopy (CRM) to determine cellularity, architecture, and morphological characteristics. A neuropathologist found that all cases showed similar histopathological features when compared to matched hematoxylin and eosin-stained sections...
December 1, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29136356/age-at-natural-menopause-and-risk-of-diabetes-in-adult-women-findings-from-the-china-kadoorie-biobank-study-in-zhejiang-area
#4
Meng Wang, Ru-Ying Hu, Hao Wang, Wei-Wei Gong, Chun-Mei Wang, Kai-Xu Xie, Zheng-Ming Chen, Yu Guo, Min Yu, Li-Ming Li
AIMS: There has been considerable professional debate on the association between age at menopause and diabetes risk, while the findings are controversial. This study explored the association between late menopause and the prevalence of diabetes in the Chinese population. MATERIAL AND METHODS: The data were part of the baseline survey of China Kadoorie Biobank from Zhejiang Province. A total of 17,076 postmenopausal women were included in the present study. Logistic regression models were used to calculate the adjusted odds ratios (ORs) and their 95% confidence intervals (CIs)...
November 14, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29130747/influence-of-storage-and-inter-and-intra-assay-variability-on-the-measurement-of-inflammatory-biomarkers-in-population-based-biobanking
#5
Robert P van Waateringe, Anneke C Muller Kobold, Jana V van Vliet-Ostaptchouk, Melanie M van der Klauw, Jan Koerts, Gabriele Anton, Annette Peters, Gerlinde Trischler, Kirsti Kvaløy, Marit Naess, Vibeke Videm, Kristian Hveem, Melanie Waldenberger, Wolfgang Koenig, Bruce H R Wolffenbuttel
BACKGROUND: In the present study, we examined the effect of sample storage on the reproducibility of several inflammatory biomarkers, including high-sensitivity C-reactive protein (hsCRP), high-sensitivity interleukin-6 (hsIL6), and high-sensitivity tumor necrosis factor alpha (hsTNFα). In addition, we assessed inter- and intra-assay variability between collaborating biobanks. METHODS: In total, 240 fasting plasma samples were obtained from the LifeLines biobank...
November 13, 2017: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/29127911/healthy-minds-from-0-100-years-optimising-the-use-of-european-brain-imaging-cohorts-lifebrain
#6
K B Walhovd, A M Fjell, R Westerhausen, L Nyberg, K P Ebmeier, U Lindenberger, D Bartrés-Faz, W F C Baaré, H R Siebner, R Henson, C A Drevon, G P Knudsen, I Budin-Ljøsne, B W J H Penninx, P Ghisletta, O Rogeberg, L Tyler, L Bertram
The main objective of "Lifebrain" is to identify the determinants of brain, cognitive and mental (BCM) health at different stages of life. By integrating, harmonising and enriching major European neuroimaging studies across the life span, we will merge fine-grained BCM health measures of more than 5,000 individuals. Longitudinal brain imaging, genetic and health data are available for a major part, as well as cognitive and mental health measures for the broader cohorts, exceeding 27,000 examinations in total...
November 8, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29122790/cohort-profile-design-and-first-results-of-the-dutch-ibd-biobank-a-prospective-nationwide-biobank-of-patients-with-inflammatory-bowel-disease
#7
Lieke M Spekhorst, Floris Imhann, Eleonora Am Festen, Ad A van Bodegraven, Nanne Kh de Boer, Gerd Bouma, Herma H Fidder, Geert D'Haens, Frank Hoentjen, Daan W Hommes, Dirk J de Jong, Mark Löwenberg, Pw Jeroen Maljaars, Andrea E van der Meulen-de Jong, Bas Oldenburg, Marieke J Pierik, Cyriel Y Ponsioen, Pieter C Stokkers, Hein W Verspaget, Marijn C Visschedijk, C Janneke van der Woude, Gerard Dijkstra, Rinse K Weersma
PURPOSE: The Dutch IBD Biobank aims to facilitate the discovery of predictors for individual disease course and treatment response in patients with inflammatory bowel disease (IBD). In this paper, we aim to describe the establishment of the Dutch IBD Biobank, including the facilitators and barriers to establishment. Moreover, we aim to provide a complete overview of the content of the Dutch IBD Biobank. PARTICIPANTS: Since 2007, every patient with IBD treated in one of the eight Dutch university medical centres is asked to participate in the Dutch IBD Biobank in which 225 standardised IBD-related data items and biomaterials, such as serum, DNA, biopsies and a stool sample, are collected...
November 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/29120959/effect-of-total-domain-specific-and-intensity-specific-physical-activity-on-all-cause-and-cardiovascular-mortality-among-hypertensive-adults-in-china
#8
Mengyu Fan, Canqing Yu, Yu Guo, Zheng Bian, Xia Li, Ling Yang, Yiping Chen, Mingqiang Li, Xianzhi Li, Junshi Chen, Zhengming Chen, Jun Lv, Liming Li
OBJECTIVES: We aimed to prospectively examine the associations of total, domain-specific, and intensity-specific physical activity with all-cause and cardiovascular mortality among Chinese hypertensive adults. METHODS: We performed a prospective cohort study in 150 391 hypertensive participants aged 30-79 years from the China Kadoorie Biobank study of 512 891 participants recruited from 10 diverse areas across China during 2004-2008. Participants with heart disease, stroke, chronic obstructive pulmonary disease, and cancer at baseline were excluded...
November 8, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29119459/ethics-and-epistemology-of-big-data
#9
Wendy Lipworth, Paul H Mason, Ian Kerridge
In this Symposium on the Ethics and Epistemology of Big Data, we present four perspectives on the ways in which the rapid growth in size of research databanks-i.e. their shift into the realm of "big data"-has changed their moral, socio-political, and epistemic status. While there is clearly something different about "big data" databanks, we encourage readers to place the arguments presented in this Symposium in the context of longstanding debates about the ethics, politics, and epistemology of biobank, database, genetic, and epidemiological research...
November 8, 2017: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/29117982/menopause-characteristics-total-reproductive-years-and-risk-of-cardiovascular-disease-among-chinese-women
#10
Ling Yang, Liling Lin, Christiana Kartsonaki, Yu Guo, Yiping Chen, Zheng Bian, Kaixu Xie, Donghui Jin, Liming Li, Jun Lv, Zhengming Chen
BACKGROUND: Previous studies, mostly of Western women, have reported inconsistent findings on the association of menopause characteristics (status, age, and time since menopause) and total reproductive years with risk of cardiovascular disease (CVD). METHODS AND RESULTS: The China Kadoorie Biobank recruited 302 632 women in 2004 to 2008 from 10 regions across China. During 9-year follow-up, 19 393 incident cases of stroke, 18 611 of ischemic heart disease, and 4978 CVD deaths occurred...
November 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29117341/association-of-physical-activity-with-risk-of-major-cardiovascular-diseases-in-chinese-men-and-women
#11
Derrick A Bennett, Huaidong Du, Robert Clarke, Yu Guo, Ling Yang, Zheng Bian, Yiping Chen, Iona Millwood, Canqing Yu, Pan He, Xiangyang Zheng, Rory Collins, Junshi Chen, Richard Peto, Liming Li, Zhengming Chen
Importance: In China, the patterns and levels of physical activity differed from those in high-income countries. Substantial uncertainty remains about the relevance, both qualitatively and quantitatively, of domain-specific physical activity for cardiovascular disease (CVD) subtypes in Chinese adults. Objective: To assess the shape and strength of the associations of total, occupational, and nonoccupational physical activity with CVD subtypes in Chinese men and women...
November 8, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29116062/-biobanks-as-the-basis-for-developing-biomedicine-problems-and-prospects
#12
O N Reznik, D O Kuzmin, A O Reznik
Biobanking is crucial for the development of life sciences in general and biomedical science in particular. A systematic study of stored biomaterials enables the discovery of new biomarkers for various physiological and pathophysiological states, identification of the drug targets, and validation of these findings in human population studies. During the last decades, the importance of biobanking has increased in parallel with the growth in their size from relatively small collections to very large national and international biorepositories...
September 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/29112751/multimorbidity-and-co-morbidity-in-atrial-fibrillation-and-effects-on-survival-findings-from-uk-biobank-cohort
#13
Bhautesh Dinesh Jani, Barbara I Nicholl, Ross McQueenie, Derek T Connelly, Peter Hanlon, Katie I Gallacher, Duncan Lee, Frances S Mair
Aims: To examine the number and type of co-morbid long-term health conditions (LTCs) and their associations with all-cause mortality in an atrial fibrillation (AF) population. Methods and results: Community cohort participants (UK Biobank n = 502 637) aged 37-73 years were recruited between 2006 and 2010. Self-reported LTCs (n = 42) identified in people with AF at baseline. All-cause mortality was available for a median follow-up of 7 years (interquartile range 76-93 months)...
November 2, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29110777/the-use-of-cerebrospinal-fluid-in-biomarker-studies
#14
C E Teunissen, C Verheul, E A J Willemse
Cerebrospinal fluid (CSF) is an extremely useful matrix for biomarker research for several purposes, such as diagnosis, prognosis, monitoring, and identification of prominent leads in pathways of neurologic diseases. Such biomarkers can be identified based on a priori hypotheses around prominent protein changes, but also by applying -omics technologies. Proteomics is widely used, but metabolomics and transcriptomics are rapidly revealing their potential for CSF studies. The basis of such studies is the availability of high-quality biobanks...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29110330/multiethnic-polygenic-risk-scores-improve-risk-prediction-in-diverse-populations
#15
Carla Márquez-Luna, Po-Ru Loh, Alkes L Price
Methods for genetic risk prediction have been widely investigated in recent years. However, most available training data involves European samples, and it is currently unclear how to accurately predict disease risk in other populations. Previous studies have used either training data from European samples in large sample size or training data from the target population in small sample size, but not both. Here, we introduce a multiethnic polygenic risk score that combines training data from European samples and training data from the target population...
November 7, 2017: Genetic Epidemiology
https://www.readbyqxmd.com/read/29107870/consent-process-for-us-based-family-reference-dna-samples
#16
Sara H Katsanis, Lindsey Snyder, Kelly Arnholt, Amy Z Mundorff
DNA collection from family members of the missing is a tenet for missing persons' and mass fatality investigations. Procedures for consenting family members are disparate, depending on the context supporting the reason for sample collection. While guidelines and best practices have been developed for handling mass fatalities and for identification of the missing, these guidelines do not address standard consent practices for living family members of potential victims. We examined the relevant U.S. laws, international guidelines and best practices, sampled consent forms currently used for DNA collection of family members, and drafted model language for a consent form to communicate the required and recommended information...
October 29, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29107084/evidence-for-m2-macrophages-in-granulomas-from-pulmonary-sarcoidosis-a-new-aspect-of-macrophage-heterogeneity
#17
Masoud Shamaei, Esmaeil Mortaz, Mihan Pourabdollah, Johan Garssen, Payam Tabarsi, Aliakbar Velayati, Ian M Adcock
BACKGROUND: Sarcoidosis is a granulomatous disease of unknown etiology. Macrophages play a key role in granuloma formation with the T cells, having a significant impact on macrophage polarization (M1 and M2) and the cellular composition of the granuloma. This study evaluates macrophage polarization in granulomas in pulmonary sarcoidosis. MATERIALS AND METHODS: Tissue specimens from the Department of Pathology biobank at the Masih Daneshvari Hospital were obtained...
October 26, 2017: Human Immunology
https://www.readbyqxmd.com/read/29106579/a-small-amount-of-precisely-measured-high-intensity-habitual-physical-activity-predicts-bone-health-in-pre-and-post-menopausal-women-in-uk-biobank
#18
Victoria H Stiles, Brad S Metcalf, Karen M Knapp, Alex V Rowlands
Background: Physical inactivity is a highly modifiable risk factor for the development of osteoporosis but, due to a lack of research that has precisely and objectively meaured physical activity (PA) relevant to bone, the specific contribution that PA can make to bone health is poorly understood. This study examined whether a more precise measure of PA relelvant to bone was associated with meaures of bone health in pre- and post-menopausal women in UK Biobank. Methods: Time spent at intensities specific to bone health [≥750 milli-gravitational units ( mg ) and ≥1000 mg ] were analysed from raw tri-axial acceleration data averaged over 1-second epochs from 7-day monitoring of habitual PA using accelerometry-based activity monitors (100 Hz; AX3, Axivity, UK) of 1218 pre- and 1316 post-menopausal healthy women...
June 29, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29106475/quantitative-serum-nuclear-magnetic-resonance-metabolomics-in-large-scale-epidemiology-a-primer-on-omic-technologies
#19
Peter Würtz, Antti J Kangas, Pasi Soininen, Debbie A Lawlor, George Davey Smith, Mika Ala-Korpela
Detailed metabolic profiling in large-scale epidemiologic studies has uncovered novel biomarkers for cardiometabolic diseases and clarified the molecular associations of established risk factors. A quantitative metabolomics platform based on nuclear magnetic resonance spectroscopy has found widespread use, already profiling over 400,000 blood samples. Over 200 metabolic measures are quantified per sample; in addition to many biomarkers routinely used in epidemiology, the method simultaneously provides fine-grained lipoprotein subclass profiling and quantification of circulating fatty acids, amino acids, gluconeogenesis-related metabolites, and many other molecules from multiple metabolic pathways...
November 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29100304/germline-variations-at-jak2-tert-hbs1l-myb-and-mecom-and-the-risk-of-myeloproliferative-neoplasms-in-taiwanese-population
#20
Yi-Hao Chiang, Yu-Cheng Chang, Huan-Chau Lin, Ling Huang, Chun-Chia Cheng, Wei-Ting Wang, Hung-I Cheng, Nai-Wen Su, Caleb Gon-Shen Chen, Johnson Lin, Yi-Fang Chang, Ming-Chih Chang, Ruey-Kuen Hsieh, Wen-Chien Chou, Ken-Hong Lim, Yuan-Yeh Kuo
Germline variations at JAK2, TERT, HBS1L-MYB and MECOM have been found to associate with myeloproliferative neoplasms (MPNs) in European populations. Whether these germline variations are associated with MPNs in Taiwanese population is obscure. Here we aimed to evaluate the association of five germline variations (JAK2 46/1 haplotype tagged by rs12343867, JAK2 intron 8 rs12339666, TERT rs2736100, HBS1L-MYB rs9376092 and MECOM rs2201862) and the risk of MPNs in Taiwanese population. A total of 178 MPN patients (109 essential thrombocythemia, 54 polycythemia vera and 15 primary myelofibrosis) were enrolled into this study...
September 29, 2017: Oncotarget
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