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https://www.readbyqxmd.com/read/29775674/the-prognostic-value-of-the-frontal-qrs-t-angle-is-comparable-to-cardiovascular-autonomic-neuropathy-regarding-long-term-mortality-in-people-with-diabetes-a-population-based-study
#1
O May, C B Graversen, M Ø Johansen, H Arildsen
Cardiovascular autonomic neuropathy (CAN) is a well known prognostic marker in diabetes. A large angle between the QRS- and the T-wave vector (QRS-T angle) in the electrocardiogram (ECG) has recently been introduced as another marker of poor prognosis. AIM: To assess and compare the long-term predictive power of the frontal plane QRS-T angle with CAN in people with diabetes. METHODS: In 1992-93 people with diabetes in the municipality of Horsens, Denmark, were identified by the prescription method andan age and gender stratified sample of 240 individuals with diabetes were randomly selected...
May 15, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29772607/mechanisms-and-drivers-of-social-inequality-in-phase-ii-cardiac-rehabilitation-attendance-a-convergent-mixed-methods-study
#2
Maria Pedersen, Dorthe Overgaard, Ingelise Andersen, Marie Baastrup, Ingrid Egerod
AIM: To explore the extent to which the qualitative and quantitative data converge and explain mechanisms and drivers of social inequality in cardiac rehabilitation attendance. BACKGROUND: Social inequality in cardiac rehabilitation attendance has been a recognized problem for many years. However, to date the mechanisms driving these inequalities are still not fully understood. DESIGN: The study was designed as a convergent mixed methods study...
May 17, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29771963/predictive-value-of-long-term-changes-of-growth-differentiation-factor-15-over-a-27-year-period-for-heart-failure-and-death-due-to-coronary-heart-disease
#3
Nina Fluschnik, Francisco Ojeda, Tanja Zeller, Torben Jørgensen, Kari Kuulasmaa, Peter Moritz Becher, Christoph Sinning, Stefan Blankenberg, Dirk Westermann
BACKGROUND: Growth differentiation factor-15 (GDF-15), Cystatin C and C-reactive protein (CRP) have been discussed as biomarkers for prediction of cardiac diseases. The aim of this study was to investigate the predictive value of single and repeated measurements of GDF-15 compared to Cystatin C and CRP for incidence of heart failure (HF) and death due to coronary heart disease (CHD) in the general population. METHODS AND RESULTS: Levels of GDF-15, CRP and Cystatin C were determined in three repeated measurements collected 5 years apart in the DAN-MONICA (Danish-Multinational MONitoring of trends and determinants in Cardiovascular disease) cohort (participants at baseline n = 3785)...
2018: PloS One
https://www.readbyqxmd.com/read/29770725/infections-seem-to-be-more-frequent-before-onset-of-pediatric-multiple-sclerosis-a-danish-nationwide-nested-case-control-study
#4
Magnus Spangsberg Boesen, Nils Koch-Henriksen, Lau Caspar Thygesen, Frank Eriksson, Gorm Greisen, Alfred Peter Born, Morten Blinkenberg, Peter Vilhelm Uldall, Melinda Magyari
BACKGROUND: Infections are suspected environmental triggers for multiple sclerosis (MS). The relationship between the timing and cumulative number of childhood infections regarding pediatric MS risk is uninvestigated. OBJECTIVES: To investigate whether childhood infections contribute to pediatric MS. METHODS: A nationwide nested case-control study with detailed MS case ascertainment including chart review was undertaken. For each MS case, we selected five control children using density sampling from the entire Danish population, matching controls to children with MS by sex and birthdate...
May 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29765253/use-of-histamine-h-2-receptor-antagonists-and-outcomes-in-patients-with-heart-failure-a-nationwide-population-based-cohort-study
#5
Kasper Adelborg, Jens Sundbøll, Morten Schmidt, Hans Erik Bøtker, Noel S Weiss, Lars Pedersen, Henrik Toft Sørensen
Background: Histamine H2 receptor activation promotes cardiac fibrosis and apoptosis in mice. However, the potential effectiveness of histamine H2 receptor antagonists (H2RAs) in humans with heart failure is largely unknown. We examined the association between H2RA initiation and all-cause mortality among patients with heart failure. Methods: Using Danish medical registries, we conducted a nationwide population-based active-comparator cohort study of new users of H2RAs and proton pump inhibitors (PPIs) after first-time hospitalization for heart failure during the period 1995-2014...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29762084/irritable-bowel-symptoms-use-of-healthcare-costs-sickness-and-disability-pension-benefits-a-long-term-population-based-study
#6
Chalotte H Poulsen, Lene F Eplov, Carsten Hjorthøj, Lene H Hastrup, Marie Eliasen, Thomas M Dantoft, Andreas Schröder, Torben Jørgensen
OBJECTIVES: Irritable bowel syndrome (IBS) is associated with increased healthcare use and work absenteeism. We aimed to investigate long-term use of healthcare services and social benefits across IBS symptom groups. Additionally, we estimated excess healthcare costs. METHODS: A longitudinal population-based study comprising two 5-year follow-up studies: The Danish part of the Multinational Monitoring of Trends and Determinants in Cardiovascular Disease (Dan-MONICA) 1 (1982-1987) and Inter99 (1999-2004) recruited from the western part of Copenhagen County...
May 1, 2018: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29761489/mortality-in-unipolar-depression-preceding-and-following-chronic-somatic-diseases-a-nationwide-danish-study
#7
A Koyanagi, O Köhler-Forsberg, M E Benros, T Munk Laursen, J M Haro, Merete Nordentoft, Carsten Hjorthøj
OBJECTIVE: It is largely unknown how depression prior to and following somatic diseases affects mortality. Thus, we examined how the temporal order of depression and somatic diseases affects mortality risk. METHOD: Data were from a Danish population-based cohort from 1995 to 2013, which included all residents in Denmark during the study period (N = 4 984 912). Nineteen severe chronic somatic disorders from the Charlson Comorbidity Index were assessed. The date of first diagnosis of depression and somatic diseases was identified...
May 14, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29757798/tinnitus-severity-is-related-to-the-sound-exposure-of-symphony-orchestra-musicians-independently-of-hearing-impairment
#8
Jesper Hvass Schmidt, Helene M Paarup, Jesper Bælum
OBJECTIVES: Tinnitus can be debilitating and with great impact of musicians professional and private life. The objectives of the study were therefore to: (1) describe the epidemiology of tinnitus including its severity in classical orchestra musicians, (2) investigate the association between tinnitus severity in classical musicians and their cumulative lifetime sound exposure, and (3) the association between tinnitus and hearing thresholds. DESIGN: The study population included all musicians from five Danish symphony orchestras...
May 11, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29755713/a-mobile-multimedia-reminiscence-therapy-application-to-reduce-behavioral-and-psychological-symptoms-in-persons-with-alzheimer-s
#9
Danish Imtiaz, Arshia Khan, Adriana Seelye
The goal of this project is to develop a novel and innovative mobile solution to address behavioral and psychological symptoms of dementia (BPSD) that occur in individuals with Alzheimer's. BPSD can include agitation, restlessness, aggression, apathy, obsessive-compulsive and repetitive behaviors, hallucinations, delusions, paranoia, and wandering. Alzheimer's currently affects 5.4 million adults in the United States and that number is projected to increase to 14 million by 2050. Almost 90% of all affected with AD experience BPSD, resulting in increased healthcare costs, heavier burden on caregivers, poor patient outcomes, early nursing home placement, long-term hospitalizations, and misuse of medications...
2018: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29754199/treatment-and-survival-of-glioblastoma-patients-in-denmark-the-danish-neuro-oncology-registry-2009-2014
#10
Steinbjørn Hansen, Birthe Krogh Rasmussen, René Johannes Laursen, Michael Kosteljanetz, Henrik Schultz, Bente Mertz Nørgård, Rikke Guldberg, Kim Oren Gradel
BACKGROUND: As many glioblastoma patients are in a poor condition they are unable to undergo the full treatment documented in clinical trials. We aimed to examine the survival and its relationship to clinical characteristics and treatment in a nationwide population of glioblastoma patients in Denmark. METHODS: We included prospectively recorded clinical data from 1364 adult patients with histologically verified glioblastoma from the Danish Neuro-Oncology Registry, 2009-2014...
May 12, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29753919/epidemiology-of-orofacial-clefts-in-a-danish-county-over-35-years-before-and-after-implementation-of-a-prenatal-screening-programme-for-congenital-anomalies
#11
Eva Berenth Paaske, Ester Garne
In 2004 the Danish National Board of Health changed its screening recommendations. Since 2005 a first trimester screening for Down syndrome and a prenatal ultrasound screening for congenital anomalies in the second trimester of pregnancy has been offered to all pregnant women. The aim of this study was to describe the prevalence of cleft lip with or without cleft palate and cleft palate in a Danish area and to describe associated anomalies and the development in prenatal diagnosis over time. The study was based on data from the EUROCAT Registry for Funen County...
May 10, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29753206/avoidable-colorectal-cancer-cases-in-denmark-the-impact-of-red-and-processed-meat
#12
Sofia Lourenço, Vibeke Berglund Gunge, Therese M-L Andersson, Camilla Liv Erthmann Andersen, Anne-Sofie Q Lund, Brian Køster, Gitte Laub Hansen
BACKGROUND: High red and processed meat intakes are associated with increased colorectal cancer (CRC) risk. The effect of eliminating or reducing red and processed meat consumption on CRC burden was not previously quantified in Denmark. The aim of this study was to calculate the possible effects of reductions in red and processed meat consumption on future CRC incidence in the Danish adult population. METHODS: Under six scenarios of prevalence exposure (meat consumption) the number of CRC cases in Denmark for a 30-year period (2016-2045) was estimated and compared to the projected number of CRCs if the prevalence of meat consumption remains constant...
May 9, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29741617/long-term-sickness-absence-from-combined-factors-related-to-physical-work-demands-prospective-cohort-study
#13
Lars L Andersen, Sannie V Thorsen, Mari-Ann Flyvholm, Andreas Holtermann
Background: The working environment plays an important role in public health. This study investigates the risk for long-term sickness absence (LTSA) from the combination of factors related to physical work demands. Methods: Employees (n = 22 740) of the general population (the Danish Work Environment & Health study 2012) were followed for two years in the Danish Register for Evaluation of Marginalisation. Using Cox regression analyses we determined the risk of LTSA from four factors; (i) physical work demands, (ii) physical exertion during work, (iii) fatigue after work and (iv) work-limiting pain...
May 5, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29741456/psychometric-properties-of-the-danish-student-well-being-questionnaire-assessed-in-250-000-student-responders
#14
Janni Niclasen, Maria Keilow, Carsten Obel
BACKGROUND: Well-being is considered a prerequisite for learning. The Danish Ministry of Education initiated the development of a new 40-item student well-being questionnaire in 2014 to monitor well-being among all Danish public school students on a yearly basis. The aim of this study was to investigate the basic psychometric properties of this questionnaire. METHODS: We used the data from the 2015 Danish student well-being survey for 268,357 students in grades 4-9 (about 85% of the study population)...
May 1, 2018: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29741136/mortality-and-its-predictors-in-patients-with-rheumatoid-arthritis-a-danish-population-based-inception-cohort-study
#15
J K Pedersen, R Holst, J Primdahl, A J Svendsen, K Hørslev-Petersen
OBJECTIVES: To investigate mortality and its predictors in a retrospectively defined population-based rheumatoid arthritis (RA) inception cohort Method: We included patients ascertained with incident RA from a region in the southern part of Denmark from 1995 to 2002. All patients fulfilled the 1987 American College of Rheumatology criteria for RA. The patients were followed from RA classification until death, emigration, or end of follow-up on 31 December 2013. We used personal record linkage with national public registers to obtain information on education, employment, cohabitation, comorbidity, and vital status...
May 9, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29741122/long-term-risk-and-outcome-of-infection-related-hospitalization-in-granulomatosis-with-polyangiitis-a-nationwide-population-based-cohort-study
#16
M Faurschou, N Obel, B Baslund
OBJECTIVE: To assess the long-term risk and outcome of infection-related hospitalization (IH) among patients with granulomatosis with polyangiitis (GPA). METHOD: We used administrative databases to establish a GPA cohort (n = 398), construct a comparison cohort of population controls (n = 3980), and collect clinical data. Cox regression analyses were used to determine hazard ratios (HRs) as a measure of relative risk. Follow-up began at date of GPA diagnosis and continued for up to 10 years...
May 9, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29736316/hpv16-viral-load-and-physical-state-measurement-as-a-potential-immediate-triage-strategy-for-hr-hpv-infected-women-a-study-in-644-women-with-single-hpv16-infections
#17
Anna Manawapat-Klopfer, Lisa Wang, Juliane Haedicke-Jarboui, Frank Stubenrauch, Christian Munk, Louise T Thomsen, Peter Martus, Susanne K Kjaer, Thomas Iftner
High genome copy number (viral load) of human papillomavirus (HPV) is being discussed as a risk factor for high-grade cervical lesions. However, conflicting data about the integration status or viral load of the virus as risk factors for prevalent high-grade squamous intraepithelial lesions (HSIL) are found in the literature. To investigate whether viral load and/or integration status are indicative for prevalent ASCUS/LSIL or HSIL, we determined the HPV16 viral load and the physical state of the genome in 644 women with single HPV16 infections stratified by their cytology results from a large Danish population-based cohort consisting of 40,399 women...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29736253/associations-of-physical-activity-with-childhood-asthma-a-population-study-based-on-the-who-health-behaviour-in-school-aged-children-survey
#18
Lene Lochte, Poul Erik Petersen, Kim G Nielsen, Anette Andersen, Thomas A E Platts-Mills
Background: Asthma in paediatric populations is one of the highest public health concerns. In this study of children and adolescents, we hypothesized that low levels of physical activity (PA) would show associations with asthma that vary by asthma outcome. The objective was to assess whether PA was associated with ever asthma and/or current asthma . Methods: Analyses were based on 4824 Danish schoolchildren aged 11-15 years old (48.7% boys) participating in the HBSC survey...
2018: Asthma Research and Practice
https://www.readbyqxmd.com/read/29733870/prevalence-and-geographical-distribution-of-insulin-pump-therapy-in-the-central-denmark-region-and-its-association-with-metabolic-parameters
#19
Ulla Kampmann, Lene Ring Madsen, Lasse Bjerg, Daniel R Witte, Kjeld Hasselstrøm, Torben Østergård, Kirsten Alstrup, Marianne Kleis Møller, Dorrit Dylmer, Klavs Würgler Hansen
AIMS: Insulin treatment in type 1 diabetes encompasses multiple daily insulin injections (MDI) or continuous subcutaneous insulin infusion (CSII). Both population-based studies and comparative studies regarding CSII use are sparse. The aim of the current study was to describe the prevalence and distribution of CSII use among adults with type 1 diabetes in the Central Denmark Region and to compare metabolic control in CSII-treated patients to those treated with MDI. METHODS: A database was constructed using the Danish Adult Diabetes Registry in 2014/2015 in combination with an audit of the patients' medical records...
May 4, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29730937/familiality-of-psychiatric-disorders-and-risk-of-postpartum-psychiatric-episodes-a-population-based-cohort-study
#20
Anna E Bauer, Merete L Maegbaek, Xiaoqin Liu, Naomi R Wray, Patrick F Sullivan, William C Miller, Samantha Meltzer-Brody, Trine Munk-Olsen
OBJECTIVE: Postpartum psychiatric disorders are common and morbid complications of pregnancy. The authors sought to evaluate how family history of psychiatric disorders is associated with postpartum psychiatric disorders in proband mothers with and without a prior psychiatric history by assessing degree of relationship, type of disorder, and sex of family members. METHOD: The authors linked Danish birth and psychiatric treatment registers to evaluate familial risk of postpartum psychiatric episodes in a national population-based cohort...
May 7, 2018: American Journal of Psychiatry
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