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https://www.readbyqxmd.com/read/28531786/malnutrition-related-deaths
#1
Maja Sparre-Sørensen, Gustav N Kristensen
BACKGROUND AND AIMS: Studies have shown that malnutrition increases the risk of morbidity, mortality, the length of hospital stay, and costs in the elderly population. Approximately one third of all patients admitted to geriatric wards in Denmark are malnourished according to the Danish Geriatric database. The aim of this study is to describe and examine the sudden increase in deaths due to malnutrition in the elderly population in Denmark from 1999 and, similarly, the sudden decline in malnutrition related deaths in 2007...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28525834/exposure-to-phenols-parabens-and-uv-filters-associations-with-loss-of-function-mutations-in-the-filaggrin-gene-in-men-from-the-general-population
#2
Ulla N Joensen, Niels Jørgensen, Jacob P Thyssen, Jørgen Holm Petersen, Pal B Szecsi, Steen Stender, Anne-Maria Andersson, Niels E Skakkebæk, Hanne Frederiksen
BACKGROUND: Filaggrin is an epidermal protein that is important for normal skin barrier functions. Up to 10% of Europeans and Asians carry filaggrin gene (FLG) loss-of function mutations that appear to facilitate trans-epidermal penetration of certain chemicals. We previously showed that mutation carriers have higher internal exposure to certain phthalates, compared to controls, and hypothesized that they could have increased trans-epidermal penetration of other chemicals. OBJECTIVES: We investigated exposure to non-persistent chemicals in young Danish men with and without FLG mutations...
May 16, 2017: Environment International
https://www.readbyqxmd.com/read/28524156/frozen-shoulder-and-risk-of-cancer-a-population-based-cohort-study
#3
Alma B Pedersen, Erzsébet Horváth-Puhó, Vera Ehrenstein, Mikael Rørth, Henrik T Sørensen
BACKGROUND: Frozen shoulder might be a complication or a presenting symptom of cancer. We examined the risk of a cancer diagnosis after an incident diagnosis of frozen shoulder. METHODS: We used prospectively collected data from Danish registries to identify patients with frozen shoulder during 1995-2013 and followed them for the development of cancer. RESULTS: We observed 2572 incident cancers among 29 098 frozen shoulder patients. The expected number of incident cancers in the general population was 2434...
May 18, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28523952/is-male-factor-infertility-associated-with-midlife-low-grade-inflammation-a-population-based-study
#4
Katia Keglberg Hærvig, Lene Kierkegaard, Rikke Lund, Helle Bruunsgaard, Merete Osler, Lone Schmidt
Male factor infertility is associated with an increased risk of disease and mortality, which has been related to markers of chronic systemic inflammation. The objective of this study was to investigate the association between male factor infertility and low-grade inflammation and furthermore to examine the lifetime prevalence of male factor infertility and overall infertility (also including female and couple infertility). The study population consisted of 2140 members of the Metropolit 1953 Danish Male Birth Cohort who had participated in the Copenhagen Aging and Midlife Biobank data collection in 2009-2011...
May 19, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28523047/alpha-thalassemia-deletions-found-in-suspected-cases-of-beta-thalassemia-major-in-pakistani-population
#5
Saba Shahid, Muhammad Nadeem, Danish Zahid, Jawad Hassan, Saqib Ansari, Tahir Shamsi
BACKGROUND & OBJECTIVE: Alpha (α) thalassemia is a hereditary disorder and is caused by deletions or mutations in globin genes. It is present in two clinically significant forms: hemoglobin Bart hydrops fetalis (Hb Bart) syndrome and hemoglobin H (HbH) disease. It is highly prevalent in South-East Asia or Mediterranean countries. The most common deletion reported in alpha thalassemia in Pakistani population was -α(3.7) with a frequency of 8.3%, and the rare forms were -α(4.2) (0.2%) and ααα(anti3...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28521886/lean-body-mass-is-the-predominant-anthropometric-risk-factor-for-atrial%C3%A2-fibrillation
#6
Morten Fenger-Grøn, Kim Overvad, Anne Tjønneland, Lars Frost
BACKGROUND: Obesity is repeatedly emphasized as a risk factor for atrial fibrillation or flutter (AF). However, the underlying evidence may be questioned, as the obvious correlations between various anthropometric measures hamper identification of the characteristics that are biologically driving AF risk, and recent studies suggest that fat carries limited or no independent risk of AF. OBJECTIVES: This study sought to assess mutually adjusted associations among AF risk and height, weight, body mass index, hip and waist circumference, waist-to-hip ratio, and bioelectrical impedance-derived measures of fat mass, lean body mass, and fat percentage...
May 23, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28521729/self-rated-health-and-functional-capacity-in-individuals-reporting-overlapping-symptoms-of-gastroesophageal-reflux-disease-functional-dyspepsia-and-irritable-bowel-syndrome-a-population-based-study
#7
Dorte Ejg Jarbøl, Sanne Rasmussen, Kirubakaran Balasubramaniam, Sandra Elnegaard, Peter Fentz Haastrup
BACKGROUND: Gastroesophageal reflux disease (GERD), functional dyspepsia (FD) and irritable bowel syndrome (IBS) are common functional gastrointestinal conditions with a significant impact on daily life. The objectives were to analyse general self-rated health and self-reported functional capacity in adults meeting the criteria for GERD, FD and IBS, respectively, and in individuals who meet the criteria for more than one of the conditions. METHODS: A nationwide study of 100,000 individuals aged 20 years and above, randomly selected in the general Danish population...
May 18, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28515065/neonatal-vitamin-d-status-from-archived-dried-blood-spots-and-future-risk-of-fractures-in-childhood-results-from-the-d-tect-study-a-population-based-case-cohort-study
#8
Mina Nicole Händel, Peder Frederiksen, Arieh Cohen, Cyrus Cooper, Berit Lilienthal Heitmann, Bo Abrahamsen
Background: Whether antenatal and neonatal vitamin D status have clinical relevance in fracture prevention has not been examined extensively, although observational studies indicate that fetal life may be a sensitive period in relation to bone growth and mineralization during childhood.Objective: We examined whether 25-hydroxyvitamin D3 [25(OH)D3] concentrations in stored neonatal dried blood spot (DBS) samples are associated with pediatric fracture risk. We hypothesized that in particular, low neonatal vitamin D status may be a risk factor for fracture incidence among children...
May 17, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28511186/search-for-internal-cancers-in-mice-tattooed-with-inks-of-high-contents-of-potential-carcinogens-a-one-year-autopsy-study-of-red-and-black-tattoo-inks-banned-in-the-market
#9
Mitra Sepehri, Catharina M Lerche, Katrina Hutton Carlsen, Jørgen Serup
BACKGROUND AND OBJECTIVE: Tattoo ink stock products often contain potential carcinogens, which on large-scale population exposure may be clinically relevant. The aim of this autopsy study in mice was to screen major organs for clinical and subclinical cancers. METHODS: Mice were tattooed on their backs. In total, 48 mice were included and divided into 4 groups; 11 mice tattooed black, 10 tattooed red, and 5 mice serving as untreated controls. A group of 22 mice with black tattoos and exposed to ultraviolet radiation (UVR) were also studied...
May 17, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28509724/associations-between-glycaemic-deterioration-and-aortic-stiffness-and-central-blood-pressure-the-addition-pro-study
#10
Nanna B Johansen, Signe S Rasmussen, Niels Wiinberg, Dorte Vistisen, Marit E Jørgensen, Erling B Pedersen, Torsten Lauritzen, Annelli Sandbæk, Daniel R Witte
OBJECTIVES: In the context of screening for diabetes, we examined levels of central haemodynamics among individuals with different levels of diabetes risk and analysed the impact of glycated haemoglobin A (HbA1c) and HbA1c changes on central haemodynamics. METHODS: A Danish population-based stepwise screening programme for diabetes including a diabetes risk score (DRS) questionnaire and glucose measurements identified seven groups of individuals at increasing levels of diabetes risk...
May 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28506478/metformin-treatment-does-not-affect-the-risk-of-ruptured-abdominal-aortic-aneurysms
#11
Katrine L Kristensen, Anton Pottegård, Jesper Hallas, Lars M Rasmussen, Jes S Lindholt
OBJECTIVE: Diabetes counteracts formation and rupture of abdominal aortic aneurysms, possibly through arterial matrix accumulation. Use of metformin, on the other hand, reduces arterial accumulation of matrix molecules. Consequently, we hypothesized that metformin treatment may reverse the protective role of diabetes on the development and course of aneurysms, that is, that metformin would be associated with aneurysm rupture among individuals with diabetes. METHODS: Using nationwide Danish registry data, we performed a nested case-control study on the association between long-term use of metformin and ruptured abdominal aortic aneurysm (RAAA)...
May 12, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28503971/mental-vulnerability-helicobacter-pylori-and-incidence-of-hospital-diagnosed-peptic-ulcer-over-28-years-in-a-population-based-cohort
#12
Susan Levenstein, Rikke Kart Jacobsen, Steffen Rosenstock, Torben Jørgensen
OBJECTIVE: To examine whether mental vulnerability, an enduring personality characteristic, predicts incident hospital-diagnosed ulcer over three decades. MATERIALS AND METHODS: A population-based cohort study enrolled 3365 subjects with no ulcer history, ages 30-60, in 1982-3. Mental vulnerability, Helicobacter pylori IgG antibodies, socioeconomic status, and sleep duration were determined at baseline; non-steroidal antiinflammatory drug use, smoking, leisure time physical activity, and alcohol consumption both at baseline and in 1993-4...
May 14, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28501739/risk-of-postpartum-episodes-in-women-with-bipolar-disorder-after-lamotrigine-or-lithium-use-during-pregnancy-a-population-based-cohort-study
#13
Richard Wesseloo, Xiaoqin Liu, Crystal T Clark, Steven A Kushner, Trine Munk-Olsen, Veerle Bergink
BACKGROUND: Women with bipolar disorder are at high risk for relapse/recurrence postpartum. Among all mood stabilizers, lithium has the largest evidence base for efficacy in the peripartum period, but lamotrigine is increasingly prescribed for bipolar spectrum disorders during pregnancy. The aim of this study was to investigate whether lamotrigine use during pregnancy is as effective as lithium in the prevention of severe episodes postpartum. METHODS: Danish national registries were used to identify pregnancies of women with a diagnosis of bipolar spectrum disorders at the time of conception who used lamotrigine or lithium during pregnancy...
May 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28500223/thirty-year-mortality-after-coronary-artery-bypass-graft-surgery-a-danish-nationwide-population-based-cohort-study
#14
Kasper Adelborg, Erzsébet Horváth-Puhó, Morten Schmidt, Troels Munch, Lars Pedersen, Per Hostrup Nielsen, Hans Erik Bøtker, Henrik Toft Sørensen
BACKGROUND: Data are sparse on long-term mortality after coronary artery bypass graft (CABG) surgery. We examined short-term and long-term mortality of patients undergoing CABG surgery and a general population comparison cohort. METHODS AND RESULTS: Linking data from Danish registries, we conducted a nationwide, population-based cohort study on 51 307 CABG patients and 513 070 individuals from the general population matched on age, sex, and calendar year (1980-2009)...
May 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28499824/quantifying-dietary-exposure-to-pesticide-residues-using-spraying-journal-data
#15
Martin Olof Larsson, Vibe Sloth Nielsen, Christian Ørsted Brandt, Niels Bjerre, Frank Laporte, Nina Cedergreen
Relatively few studies are available on the combined risk of realistic dietary pesticide exposure. Despite available studies showing low risk, public concern remains. Recent methods used to estimate realistic exposure levels have a number of drawbacks, and better methods are needed. Using a novel approach, we estimated the combined exposure in the Danish population, resulting from pesticide usage in Danish agriculture. The complete Danish spraying journal data from 2014, and supervised trial residue levels reported by EFSA, were used in combination, generating residue estimates in 25 crops...
May 9, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28490661/surgery-for-subacromial-impingement-syndrome-in-relation-to-occupational-exposures-lifestyle-factors-and-diabetes-mellitus-a-nationwide-nested-case-control-study
#16
Annett Dalbøge, Poul Frost, Johan Hviid Andersen, Susanne Wulff Svendsen
OBJECTIVES: To estimate the risk of surgery for subacromial impingement syndrome (SIS) in relation to occupational exposures, lifestyle factors and diabetes mellitus. METHODS: We conducted a case-control study nested in a register-based cohort study of the Danish working population. For each of 3000 first-time cases of surgery for SIS, two age-matched and sex-matched controls were drawn. Cases and controls received a questionnaire on job history and other factors...
May 10, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28487451/infant-feeding-and-risk-of-type-1-diabetes-in-two-large-scandinavian-birth-cohorts
#17
Nicolai A Lund-Blix, Stine Dydensborg Sander, Ketil Størdal, Anne-Marie Nybo Andersen, Kjersti S Rønningen, Geir Joner, Torild Skrivarhaug, Pål R Njølstad, Steffen Husby, Lars C Stene
OBJECTIVE: Our aim was to study the relation between the duration of full and any breastfeeding and risk of type 1 diabetes. RESEARCH DESIGN AND METHODS: We included two population-based cohorts of children followed from birth (1996-2009) to 2014 (Denmark) or 2015 (Norway). We analyzed data from a total of 155,392 children participating in the Norwegian Mother and Child Cohort Study and the Danish National Birth Cohort. Parents reported infant dietary practices when their child was 6 and 18 months old...
May 9, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28486983/social-disparities-in-the-prevalence-of-multimorbidity-a-register-based-population-study
#18
Michaela L Schiøtz, Anders Stockmarr, Dorte Høst, Charlotte Glümer, Anne Frølich
BACKGROUND: Prevalences of multimorbidity vary between European studies and several methods and definitions are used. In this study we examine the prevalence of multimorbidity in relation to age, gender and educational attainment and the association between physical and mental health conditions and educational attainment in a Danish population. METHODS: A cross-sectional design was used to study the prevalence of multimorbidity, defined as two or more chronic conditions, and of comorbid physical and mental health conditions across age groups and educational attainment levels among 1,397,173 individuals aged 16 years and older who lived in the Capital Region of Denmark on January 1st, 2012...
May 10, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28486626/proximal-disease-extension-in-patients-with-limited-ulcerative-colitis-a-danish-population-based-inception-cohort
#19
J Burisch, R Ungaro, I Vind, M V Prosberg, F Bendtsen, J-F Colombel, M K Vester-Andersen
Background and aims: Disease extent in ulcerative colitis (UC) is dynamic and can progress over time. Little is known about risk factors for UC extension in the era of biologics. We investigated the risk of UC extension and subsequent risk of surgery in a Danish population-based cohort. Methods: All incident UC cases in a strictly defined Copenhagen area between 2003 and 2004 were followed prospectively through 2011. Disease extension was defined as patients with limited UC (E1 or E2) at diagnosis having progressed from the initial extent by colonoscopy or surgery to E2 or extensive colitis (E3)...
May 9, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28486520/rapid-expansion-of-the-invasive-oyster-crassostrea-gigas-at-its-northern-distribution-limit-in-europe-naturally-dispersed-or-introduced
#20
Marc B Anglès d'Auriac, Eli Rinde, Pia Norling, Sylvie Lapègue, André Staalstrøm, Dag Ø Hjermann, Jens Thaulow
The Pacific oyster, Crassostrea gigas, was introduced to Europe for aquaculture purposes, and has had a rapid and unforeseen northward expansion in northern Europe. The recent dramatic increase in number of C. gigas populations along the species' northern distribution limit has questioned the efficiency of Skagerrak as a dispersal barrier for transport and survival of larvae. We investigated the genetic connectivity and possible spreading patterns between Pacific oyster populations on the southern Norwegian coast (4 localities) and Swedish and Danish populations by means of DNA microsatellite analysis of adult oysters, and by simulating larvae drift...
2017: PloS One
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