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https://www.readbyqxmd.com/read/28100713/ahrr-cg05575921-hypomethylation-marks-smoking-behaviour-morbidity-and-mortality
#1
Stig E Bojesen, Nicholas Timpson, Caroline Relton, George Davey Smith, Børge G Nordestgaard
RATIONALE AND OBJECTIVES: Self-reported smoking underestimates disease risk. Smoking affects DNA methylation, in particular the cg05575921 site in the aryl hydrocarbon receptor repressor (AHRR) gene. We tested the hypothesis that AHRR cg05575921 hypomethylation is associated with risk of smoking-related morbidity and mortality. METHODS: From the Copenhagen City Heart Study representing the Danish general population, we studied 9234 individuals. Using bisulphite treated leucocyte DNA, AHRR (cg05575921) methylation was measured...
January 18, 2017: Thorax
https://www.readbyqxmd.com/read/28099266/posttraumatic-stress-disorder-and-gastrointestinal-disorders-in-the-danish-population
#2
Jaimie L Gradus, Dóra Körmendiné Farkas, Elisabeth Svensson, Vera Ehrenstein, Timothy L Lash, Henrik Toft Sørensen
BACKGROUND: Evidence for the association between posttraumatic stress disorder (PTSD) and gastrointestinal (GI) disorders is mixed, owing in part to methodologic differences across studies. Further, studies which have combined GI disorders or symptoms for examination as one overall category may potentially obscure associations between PTSD and individual GI diagnoses. METHODS: This nationwide cohort study examined the incidence of all major non-malignant GI disorders in patients with a prior PTSD diagnosis (n = 4,076), compared to the general population incidence from 1995-2013, using Danish medical registry data...
January 17, 2017: Epidemiology
https://www.readbyqxmd.com/read/28095477/the-burden-of-mental-disorders-in-the-eastern-mediterranean-region-1990-2013
#3
Raghid Charara, Mohammad Forouzanfar, Mohsen Naghavi, Maziar Moradi-Lakeh, Ashkan Afshin, Theo Vos, Farah Daoud, Haidong Wang, Charbel El Bcheraoui, Ibrahim Khalil, Randah R Hamadeh, Ardeshir Khosravi, Vafa Rahimi-Movaghar, Yousef Khader, Nawal Al-Hamad, Carla Makhlouf Obermeyer, Anwar Rafay, Rana Asghar, Saleem M Rana, Amira Shaheen, Niveen M E Abu-Rmeileh, Abdullatif Husseini, Laith J Abu-Raddad, Tawfik Khoja, Zulfa A Al Rayess, Fadia S AlBuhairan, Mohamed Hsairi, Mahmoud A Alomari, Raghib Ali, Gholamreza Roshandel, Abdullah Sulieman Terkawi, Samer Hamidi, Amany H Refaat, Ronny Westerman, Aliasghar Ahmad Kiadaliri, Ali S Akanda, Syed Danish Ali, Umar Bacha, Alaa Badawi, Shahrzad Bazargan-Hejazi, Imad A D Faghmous, Seyed-Mohammad Fereshtehnejad, Florian Fischer, Jost B Jonas, Barthelemy Kuate Defo, Alem Mehari, Saad B Omer, Farshad Pourmalek, Olalekan A Uthman, Ali A Mokdad, Fadi T Maalouf, Foad Abd-Allah, Nadia Akseer, Dinesh Arya, Rohan Borschmann, Alexandra Brazinova, Traolach S Brugha, Ferrán Catalá-López, Louisa Degenhardt, Alize Ferrari, Josep Maria Haro, Masako Horino, John C Hornberger, Hsiang Huang, Christian Kieling, Daniel Kim, Yunjin Kim, Ann Kristin Knudsen, Philip B Mitchell, George Patton, Rajesh Sagar, Maheswar Satpathy, Kim Savuon, Soraya Seedat, Ivy Shiue, Jens Christoffer Skogen, Dan J Stein, Karen M Tabb, Harvey A Whiteford, Paul Yip, Naohiro Yonemoto, Christopher J L Murray, Ali H Mokdad
The Eastern Mediterranean Region (EMR) is witnessing an increase in chronic disorders, including mental illness. With ongoing unrest, this is expected to rise. This is the first study to quantify the burden of mental disorders in the EMR. We used data from the Global Burden of Disease study (GBD) 2013. DALYs (disability-adjusted life years) allow assessment of both premature mortality (years of life lost-YLLs) and nonfatal outcomes (years lived with disability-YLDs). DALYs are computed by adding YLLs and YLDs for each age-sex-country group...
2017: PloS One
https://www.readbyqxmd.com/read/28095160/minimal-loss-of-lifetime-for-patients-with-diffuse-large-b-cell-lymphoma-in-remission-and-event-free-24-months-after-treatment-a-danish-population-based-study
#4
Lasse Hjort Jakobsen, Martin Bøgsted, Peter de Nully Brown, Bente Arboe, Judit Jørgensen, Thomas Stauffer Larsen, Maja Bech Juul, Lene Schurmann, Linda Højberg, Olav Jonas Bergmann, Therese Lassen, Pär Lars Josefsson, Paw Jensen, Hans Erik Johnsen, Tarec Christoffer El-Galaly
Purpose The general outlook for patients with diffuse large B-cell lymphoma (DLBCL) in first remission is important information for patients and for planning post-treatment follow-up. The purpose of this study was to evaluate the survival of patients with DLBCL in remission compared with a matched general population. Methods A total of 1,621 patients from the Danish Lymphoma Registry who were newly diagnosed with DLBCL between 2003 and 2011 were included in this study. All patients were ≥ 16 years of age at diagnosis and had achieved complete remission or complete remission unconfirmed after first-line rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) or R-CHOP-like therapy...
January 17, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28094199/risk-of-prostate-cancer-diagnosis-and-mortality-in-men-with-a-benign-initial-transrectal-ultrasound-guided-biopsy-set-a-population-based-study
#5
Nina Klemann, M Andreas Røder, J Thomas Helgstrand, Klaus Brasso, Birgitte G Toft, Ben Vainer, Peter Iversen
BACKGROUND: The risk of missing prostate cancer in the transrectal ultrasound-guided systematic biopsies of the prostate in men with suspected prostate cancer is a key problem in urological oncology. Repeat biopsy or MRI-guided biopsies have been suggested to increase sensitivity for diagnosis of prostate cancer, but the risk of disease-specific mortality in men who present with raised prostate-specific antigen (PSA) concentration and a benign initial biopsy result remains unknown. We investigated the risk of overall and prostate cancer-specific mortality in men with a benign initial biopsy set...
January 13, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28090651/incidence-of-skin-and-respiratory-diseases-among-danish-hairdressing-apprentices
#6
Majken H Foss-Skiftesvik, Lone Winther, Claus R Johnsen, Claus Zachariae, Jeanne D Johansen
BACKGROUND: Hairdressing is one of the professions with the highest risk of occupational skin and respiratory diseases. The incidence of these diseases in hairdressing apprentices has been studied only sparsely. OBJECTIVE: To determine the incidence of skin and respiratory diseases in hairdressing apprentices, and to explore whether hairdressing apprentices leave the trade during training because of these diseases. METHODS: A 3-year follow-up questionnaire study was conducted among 248 hairdressing apprentices and a control group comprising 816 young adults from the general population...
January 16, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28089709/objective-assessment-of-dietary-patterns-by-use-of-metabolic-phenotyping-a-randomised-controlled-crossover-trial
#7
Isabel Garcia-Perez, Joram M Posma, Rachel Gibson, Edward S Chambers, Tue H Hansen, Henrik Vestergaard, Torben Hansen, Manfred Beckmann, Oluf Pedersen, Paul Elliott, Jeremiah Stamler, Jeremy K Nicholson, John Draper, John C Mathers, Elaine Holmes, Gary Frost
BACKGROUND: Accurate monitoring of changes in dietary patterns in response to food policy implementation is challenging. Metabolic profiling allows simultaneous measurement of hundreds of metabolites in urine, the concentrations of which can be affected by food intake. We hypothesised that metabolic profiles of urine samples developed under controlled feeding conditions reflect dietary intake and can be used to model and classify dietary patterns of free-living populations. METHODS: In this randomised, controlled, crossover trial, we recruited healthy volunteers (aged 21-65 years, BMI 20-35 kg/m(2)) from a database of a clinical research unit in the UK...
January 12, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28089682/prevalence-and-risk-of-inflammatory-bowel-disease-in-patients-with-hidradenitis-suppurativa
#8
Alexander Egeberg, Gregor B E Jemec, Alexa B Kimball, Hervé Bachelez, Gunnar H Gislason, Jacob P Thyssen, Lotus Mallbris
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. In small studies, inflammatory bowel disease (IBD) has been associated with increased prevalence of HS, but data on the concurrence of IBD in patients with HS is limited. We therefore investigated the prevalence and risk of IBD in patients with HS compared with the general population. The study linked all Danish individuals ≥18 years in nationwide registers. Adjusted odds ratios (OR) and adjusted hazard ratios (HRs) were estimated by logistic regression and Cox regression, respectively...
January 12, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28087543/leisure-time-sport-and-overuse-injuries-of-extremities-in-children-age-6-13-a-2-5%C3%A2-years-prospective-cohort-study-the-champs-study-dk
#9
Charlène Chéron, Charlotte Leboeuf-Yde, Christine Le Scanff, Eva Jespersen, Christina Trifonov Rexen, Claudia Franz, Niels Wedderkopp
OBJECTIVES: It is not known which sports are most likely to cause overuse injuries of the extremities in children. In this study, we report on the incidence of overuse injuries of the upper and lower extremities in children who participate in various leisure-time sports and relate this to the frequency of sport sessions. DESIGN: Natural experiment including a prospective cohort study. SETTING: 10 state schools in 1 Danish municipality: Svendborg...
January 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28081550/ninth-grade-school-performance-in-danish-childhood-cancer-survivors
#10
Klaus Kaae Andersen, Anne Katrine Duun-Henriksen, Marie Hoffmann Frederiksen, Jeanette Falck Winther
BACKGROUND: Childhood cancer survivors can experience learning problems resulting in lower-than-expected attained education as adults. It is unclear whether learning problems manifest already during adolescence. METHODS: We analysed nationwide Danish registries on school grades for Danish children during 2001-2014. Applying a matched design we compared grades of childhood cancer survivors to children without cancer at ninth grade. We estimated grade differences by subject and its correlation to cancer site and age at diagnosis...
January 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28080187/early-life-risk-factors-for-testicular-cancer-a-case-cohort-study-based-on-the-copenhagen-school-health-records-register
#11
Johanne Spanggaard Piltoft, Signe Benzon Larsen, Susanne Oksbjerg Dalton, Christoffer Johansen, Jennifer L Baker, Luise Cederkvist, Ingelise Andersen
PURPOSE: One established risk factors for testicular cancer is cryptorchidism. However, it remains unclear whether cryptorchidism is a risk factor in itself or whether the two conditions share common causes in early life (estrogen hypothesis), such as birth weight and birth order. The objective of this study is to utilize data from the Copenhagen School Health Records Register (CSHRR) to evaluate cryptorchidism, birth weight and birth order as risk factors for testicular cancer. METHODS: The study population consisted of 408 cases of testicular cancer identified by a government issued identification number linkage of the entire CSHRR with the Danish Cancer Registry and a random subsample of 4819 males from the CSHRR...
January 12, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28080157/detection-of-recurrence-in-early-stage-endometrial-cancer-the-role-of-symptoms-and-routine-follow-up
#12
Mette Moustgaard Jeppesen, Ole Mogensen, Dorte Gilså Hansen, Maria Iachina, Malene Korsholm, Pernille Tine Jensen
BACKGROUND: Considerable controversy remains as to the optimal organization of endometrial cancer follow-up. AIM: To evaluate the relationship between the way recurrence was detected and survival after treatment for endometrial cancer. Further, to identify characteristics associated with a pre-scheduled examination in women with symptomatic recurrence. MATERIAL AND METHODS: All women with early stage endometrial cancer during 2005-2009 were included in a population-based historical cohort derived from the Danish Gynecological Cancer Database...
January 12, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28079429/association-between-late-effects-assessed-by-physicians-and-quality-of-life-reported-by-head-and-neck-cancer-survivors
#13
Rikke Daugaard, Trille Kjaer, Christoffer Johansen, Jane Christiansen, Elo Andersen, Anni L Nielsen, Susanne O Dalton
BACKGROUND: Many survivors of head-and-neck cancer (HNC) suffer from late effects. Their overall quality of life deteriorates during treatment, followed by a slow recovery up to five years after treatment. We examined the association between the severity of physician-assessed late effects and the health-related quality of life (HRQoL) reported by survivors of HNC. MATERIAL AND METHODS: The analysis was based on data collected during follow-up for 136 survivors of cancer in the oral cavity, pharynx, larynx, or salivary glands...
January 12, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28078919/cultural-competence-in-medical-education-a-questionnaire-study-of-danish-medical-teachers-perceptions-of-and-preparedness-to-teach-cultural-competence
#14
Janne Sorensen, Signe Smith Jervelund, Marie Norredam, Maria Kristiansen, Allan Krasnik
AIMS: The cultural competence training of healthcare professionals is a key element in ensuring the quality of both the access and delivery of healthcare to increasingly ethnically diverse populations. The aim of this study is to investigate Danish medical teachers' opinions about cultural competence, their willingness to receive training and preparedness to teach cultural competence topics. METHODS: The survey was sent to medical teachers, clinical teachers and external lecturers who teach in the medical programme at the University of Copenhagen...
January 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28078491/prognostic-factors-in-early-breast-cancer-associated-with-body-mass-index-physical-functioning-physical-activity-and-comorbidity-data-from-a-nationwide-danish-cohort
#15
Trine L Guldberg, Søren Christensen, Robert Zachariae, Anders Bonde Jensen
PURPOSE: To explore the associations between lifestyle-related factors and tumor-related prognostic factors in women treated for primary breast cancer, and to detect possible differences between the associations in pre- and postmenopausal women. METHODS: Associations between tumor-related prognostic factors, including the composite endpoint risk of recurrence (RoR), body mass index (BMI), comorbidity (Charlson comorbidity index), basic physical functioning (SF-36), physical activity, smoking, and alcohol consumption were examined with binary logistic regression analysis in a national cohort of 4917 women treated for primary breast cancer...
January 11, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28077691/establishment-and-baseline-characteristics-of-a-nationwide-danish-cohort-of-patients-with-ehlers-danlos-syndrome
#16
Marie-Louise Kulas Søborg, Julie Leganger, Laura Quitzau Mortensen, Jacob Rosenberg, Jakob Burcharth
OBJECTIVES: The aim of this study was to investigate national prevalence, general demographic characteristics and survival of Danish patients with Ehlers-Danlos syndrome (EDS). METHOD: A population-based cohort study was conducted using a database consisting of the entire Danish population alive at any given time between 1 January 2000 and 31 December 2012, based upon longitudinal Danish national registers. All patients with EDS were identified, and the cohort was described by disease prevalence, basic demographic characteristics, mean age at death and mortality for the observational period of 13 years...
January 11, 2017: Rheumatology
https://www.readbyqxmd.com/read/28069620/prenatal-exposure-to-antiepileptic-drugs-and-use-of-primary-healthcare-during-childhood-a-population-based-cohort-study-in-denmark
#17
Anne Mette Würtz, Dorte Rytter, Claus Høstrup Vestergaard, Jakob Christensen, Mogens Vestergaard, Bodil Hammer Bech
OBJECTIVE: Prenatal exposure to antiepileptic drugs (AEDs) has been associated with adverse outcomes in the offspring such as congenital malformations and neuropsychiatric disorders. The objective of this study was to investigate whether prenatal exposure to AEDs is also associated with more frequent use of primary healthcare during childhood. DESIGN: Population-based cohort study. SETTING: Nationwide national registers in Denmark. PARTICIPANTS: All live-born singletons in Denmark during 1997-2012 identified in the Danish National Patient Register and followed until 31 December 2013 (n=963 010)...
January 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28065667/a-large-frontal-qrs-t-angle-is-a-strong-predictor-of-the-long-term-risk-of-myocardial-infarction-and-all-cause-mortality-in-the-diabetic-population
#18
Ole May, Christina Boesgaard Graversen, Mia Østergaard Johansen, Hanne Arildsen
BACKGROUND: A large angle between the QRS vector and the T-wave vector (QRS-T angle) in electrocardiograms (ECGs) has recently been introduced as a marker of poor prognosis. The prognostic value in diabetes is unknown. We assessed the long-term predictive power of the frontal plane QRS-T angle in the diabetic population. METHODS: In 1992-93, the diabetic population of the municipality of Horsens, Denmark, was delineated by the prescription method, and an age- and gender-stratified sample of 240 diabetic persons was randomly selected...
December 16, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28064098/long-term-follow-up-after-abdominal-cerclage-a-population-based-cohort-study
#19
Kirstine Sneider, Ole Bjarne Christiansen, Iben Blaabjerg Sundtoft, Jens Langhoff-Roos
OBJECTIVE: To study the long-term pregnancy outcomes and complications after application of abdominal cerclage. STUDY DESIGN: Population-based cohort of 255 women with abdominal cerclage in 1999-2012 based on data from the Danish National Patient Register, supplemented and validated by medical records and a questionnaire. Women were categorized by surgical placement of abdominal cerclage via laparotomy or laparoscopy. OUTCOMES: were gestational length and results of subsequent pregnancies as well as perioperative and long-term complications...
January 3, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28062627/association-of-repeatedly-measured-high-sensitivity-assayed-troponin-i-with-cardiovascular-disease-events-in-a-general-population-from-the-morgam-biomarcare-study
#20
Maria F Hughes, Francisco Ojeda, Olli Saarela, Torben Jørgensen, Tanja Zeller, Tarja Palosaari, Mark G O'Doherty, Anders Borglykke, Kari Kuulasmaa, Stefan Blankenberg, Frank Kee
BACKGROUND: High-sensitivity troponin I (hs-cTnI) concentrations reflect myocardial stress. The role of hs-cTnI in predicting long-term changes in the risk of cardiovascular disease (CVD) in general populations is not clearly defined. METHODS: We investigated whether the change in 3 repeated measures of hs-cTnI collected 5 years apart in a prospective Danish study (3875 participants, initially aged 30-60 years, 51% female, disease free at baseline) improves 10-year prediction of incident CVD compared to using a single most recent hs-cTnI measurement...
January 2017: Clinical Chemistry
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