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https://www.readbyqxmd.com/read/28811770/clinical-and-laboratory-profile-of-children-with-cystic-fibrosis-experience-of-a-tertiary-care-center-in-pakistan
#1
Danish Abdul Aziz, Abdul Gaffar Billoo, Ahad Qureshi, Misha Khalid, Salman Kirmani
OBJECTIVE: To determine the clinical presentation, diagnostic investigations and laboratory workup done in admitted children with cystic fibrosis at Aga Khan University Hospital Karachi, Pakistan. METHODS: This is athree years retrospective study from January 2013 to December 2015 conducted at The Aga Khan University Hospital Karachi Pakistan, enrolling admitted patient from birth to 15 years of either gender, diagnosed with CF on the basis of clinical features and positive sweat chloride test...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28811542/identification-replication-and-characterization-of-epigenetic-remodelling-in-the-aging-genome-a-cross-population-analysis
#2
Shuxia Li, Lene Christiansen, Kaare Christensen, Torben A Kruse, Paul Redmond, Riccardo E Marioni, Ian J Deary, Qihua Tan
Aging is a complex biological process regulated by multiple cellular pathways and molecular mechanisms including epigenetics. Using genome-wide DNA methylation data measured in a large collection of Scottish old individuals, we performed discovery association analysis to identify age-methylated CpGs and replicated them in two independent Danish cohorts. The double-replicated CpGs were characterized by distribution over gene regions and location in relation to CpG islands. The replicated CpGs were further characterized by involvement in biological pathways to study their functional implications in aging...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811132/relative-changes-in-earned-income-five-years-after-diagnosis-with-diabetes-a-register-based-study-1996-2012
#3
Bryan Cleal, Ulrik Haagen Panton, Ingrid Willaing, Richard I G Holt
OBJECTIVE: With previous studies indicating that diabetes affects employment status and lifetime earnings, the aim of this study was to determine the impact on earnings in the immediate period after diagnosis. Recognising that earnings and employment status are dynamic over the life course, we matched people with diabetes to counterparts in the general population and compared nominal growth in earned income five calendar years after diagnosis. RESEARCH DESIGN AND METHODS: The study draws upon Danish population registers...
July 9, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28810914/eliciting-meta-consent-for-future-secondary-research-use-of-health-data-using-a-smartphone-application-a-proof-of-concept-study-in-the-danish-population
#4
Thomas Ploug, Søren Holm
BACKGROUND: The increased use of information technology in every day health care creates vast amounts of stored health data that can be used for research. The secondary research use of routinely collected data raises questions about appropriate consent mechanisms for such use. One option is meta consent where individuals state their own consent preferences in relation to future use of their data, e.g. whether they want the data to be accessible to researchers under conditions of specific consent, broad consent, blanket consent or not at all...
August 15, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/28810815/social-selection-in-cohort-studies-and-later-representation-of-childhood-psychiatric-diagnoses-the-danish-national-birth-cohort
#5
Kathrine Bang Madsen, Lena Hohwü, Jin Liang Zhu, Jørn Olsen, Carsten Obel
AIM: This study aimed to estimate the relative representation of childhood psychiatric diagnoses and use of psychotropic medication in the Danish National Birth Cohort (DNBC) compared to the general population. METHODS: The general population was identified as all childbirths in Denmark during 1998-2002 ( N=344,160). Linking the DNBC ( N=91,442) and the general population to the Danish national health registries, all children were followed until they received an ICD-10 psychiatric diagnosis, had a prescription of psychotropic medication or to the end of follow-up in 2013...
August 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28807680/patient-characteristics-and-cancer-prevalence-in-the-danish-cancer-patient-pathway-for-patients-with-serious-non-specific-symptoms-and-signs-of-cancer-a-nationwide-population-based-cohort-study
#6
E Moseholm, B Ø Lindhardt
BACKGROUND: A new cancer patient pathway for patients presenting with non-specific signs and symptoms (NSSC-CPP) was implemented nationally in Denmark in 2012. This study aims to describe, on a national level, the characteristics of patients referred to the Danish NSSC-CPP, and to estimate the prevalence and distribution of cancers and other diagnosis in this population. METHODS: A population-based cohort study using the Danish national registries, including all patients who completed a diagnostic course through the NSSC-CPP between 2012 and 2015...
August 11, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28805103/dentoalveolar-oral-surgery-in-children-and-adolescents-organization-and-surgical-treatment-in-a-large-danish-municipal-dental-service
#7
Anni Birgitte Grønbæk, Flemming Petersen, Dorte Haubek, Sven Poulsen
OBJECTIVE: To describe a population-based organization of dentoalveolar surgical service for 0 to 18-year old subjects in a Danish municipal dental service, and analyze the type of dentoalveolar surgical interventions needed. MATERIAL AND METHODS: The study was conducted in the Municipality of Aarhus, Denmark during five consecutive school-years. An internal referral system was established within the municipality where patients could be referred to colleagues with a higher level of competencies and more experiences with paediatric dentoalveolar surgery...
August 13, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28803571/a-national-register-based-study-of-paediatric-varicella-hospitalizations-in-denmark-2010-2016
#8
I G Helmuth, A Poulsen, K Mølbak
Varicella, usually a mild disease of childhood, can also cause complications and hospitalization. Universal varicella immunization is implemented in several countries worldwide, but not in Denmark. Taking advantage of unique national registers, we aimed to estimate the incidence of paediatric varicella hospitalizations and assess determinants for hospitalization. For this purpose, we designed a nationwide, retrospective register study of paediatric varicella hospitalizations and applied a case-cohort design and logistic regression analysis comparing hospitalized varicella patients to a sample of the entire paediatric population in Denmark...
August 14, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28799428/full-spectrum-endoscopy-fuse-versus-standard-forward-viewing-endoscope-sfv-in-a-high-risk-population
#9
Søren Roepstorff, Sabah Anwar Hadi, Morten Rasmussen
OBJECTIVES: To investigate the diagnostic performance of Full Spectrum Endoscopy (FUSE) compared to a conventional standard forward-viewing endoscope (SFV). The primary outcome was adenoma detection rate (ADR) and mean adenoma detection. Secondary outcome was feasibility of FUSE opposed to SFV. MATERIALS AND METHODS: Consecutive patients participating in the Danish colorectal cancer (CRC) screening programme were prospectively included in the study (n = 205)...
August 11, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28796371/inflammatory-bowel-disease-with-primary-sclerosing-cholangitis-a-danish-population-based-cohort-study-1977-2011
#10
Jakob Ørskov Sørensen, Ole Haagen Nielsen, Mikael Andersson, Mark Andrew Ainsworth, Henriette Ytting, Erika Bélard, Tine Jess
BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) may be complicated by primary sclerosing cholangitis (PSC). We aimed to assess the characteristics of Danish PSC-IBD patients and to compare their prognosis with IBD patients without PSC. METHODS: A retrospective nationwide population-based cohort of 257 PSC-IBD patients was assessed through Danish national registries and manual scrutiny of patient files. RESULTS: For all PSC-IBD patients diagnosed after 1976 (n=222) and 8,231 IBD controls (i...
August 10, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28793177/infants-with-prenatally-diagnosed-kidney-anomalies-have-an-increased-risk-of-urinary-tract-infections
#11
Maria Rasmussen, Lone Sunde, René Frydensbjerg Andersen, Olav Bjørn Petersen, Morten Smaerup Olsen
AIM: This study estimated the urinary tract infection (UTI) risk in a nationwide cohort of infants prenatally diagnosed with parenchymal kidney anomalies compared with a comparison cohort. METHODS: A Danish population-based nationwide cohort of fetuses diagnosed with parenchymal kidney anomalies between 2007 and 2012 had previously been identified. These were compared with fetuses without kidney anomalies who were prenatally scanned the same year. Live born infants were followed from birth until the diagnosis of UTI, emigration, death or two years of age...
August 9, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28791695/use-of-antidepressants-and-risk-of-epithelial-ovarian-cancer
#12
Lina S Mørch, Christian Dehlendorff, Louise Baandrup, Søren Friis, Susanne K Kjaer
Antidepressants are widely prescribed among women to treat depression and anxiety disorders, but studies of their effects on gynecological cancer risk are sparse. We assessed associations between various antidepressants and risk of epithelial ovarian cancer. By using Danish nationwide registers, we identified all women (cases) aged 30 to 84 years with incident epithelial (serous, endometrioid, clear cell or mucinous) ovarian cancer during 2000-2011 (n= 4,103) and matched each case to 20 population controls (n=58,706) by risk-set matching...
August 9, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28791473/59-eyes-with-endogenous-endophthalmitis-causes-outcomes-and-mortality-in-a-danish-population-between-2000-and-2016
#13
Søren Solborg Bjerrum, Morten la Cour
BACKGROUND: To study the epidemiology of patients with endogenous endophthalmitis in Denmark. MATERIAL AND METHODS: Retrospective and prospective case series of 59 eyes in patients with endogenous endophthalmitis in Denmark between 2000 and 2016. RESULTS: The age of the patients ranged from 28 to 90 years with a median of 66 years. Sixty-two percent of the eyes had a final VA (visual acuity) ≤ 0.1 while 8% had a final VA ≥ 1.0. Positive cultures were obtained in 51% of the cases from the blood and in 43% from the vitreous...
August 8, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28777767/social-capital-and-workplace-bullying
#14
Patricia Pihl, Karen Albertsen, Annie Hogh, Lars Peter Sønderbo Andersen
BACKGROUND: Workplace bullying is a serious stressor with devastating short- and long-term consequences. The concept of organizational social capital may provide insights into the interactional and communicative dynamics of the bullying process and opportunities for prevention. OBJECTIVE: This study aimed to explore the association between organizational social capital and being a target or observer of workplace bullying. METHODS: Based on self-reported cross-sectional data from a large representative sample of the Danish working population (n = 10...
August 1, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28774965/assembly-and-analysis-of-100-full-mhc-haplotypes-from-the-danish-population
#15
Jacob Malte Jensen, Palle Villesen, Rune M Friborg, Thomas Mailund, Søren Besenbacher, Mikkel H Schierup
Genes in the major histocompatibility complex (MHC, also known as HLA) play a critical role in the immune response and variation within the extended 4 Mb region shows association with major risks of many diseases. Yet, deciphering the underlying causes of these associations is difficult because the MHC is the most polymorphic region of the genome with a complex linkage disequilibrium structure. Here we reconstruct full MHC haplotypes from de novo assembled trios without relying on a reference genome and perform evolutionary analyses...
August 3, 2017: Genome Research
https://www.readbyqxmd.com/read/28774428/quality-of-care-and-outcomes-of-heart-failure-among-patients-with-schizophrenia-in-denmark
#16
Mette Jørgensen, Jan Mainz, Kenneth Egstrup, Søren P Johnsen
Research on the association between schizophrenia and the quality of care and clinical outcomes of heart failure (HF) remains sparse. This nationwide study compared the quality of care and clinical outcomes of HF among Danish patients with and without schizophrenia. In a population-based cohort study, we identified 36,718 patients with incident HF with hospital contacts, including 108 with schizophrenia, using Danish registries between 2004 and 2013. High quality of HF care was defined as receiving ≥ 80% guideline-recommended process-performance measures of care...
June 27, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28772007/the-impact-of-comorbidities-on-tumor-necrosis-factor-inhibitor-therapy-in-psoriatic-arthritis-a-population-based-cohort-study
#17
Christine Ballegaard, Pil Højgaard, Lene Dreyer, René Cordtz, Tanja Schjødt Jørgensen, Marie Skougaard, Simon Tarp, Lars Erik Kristensen
OBJECTIVE: The objective of this population-based cohort study was to investigate the impact of comorbidities on disease activity, treatment response and persistence with the first-tried tumor necrosis factor inhibitor (TNFi) in patients with psoriatic arthritis (PsA). METHODS: Data on patient characteristics, disease activity and treatment response and persistence was obtained from the DANBIO registry. Information on comorbidities according to the Charlson Comorbidity Index (CCI) was obtained through linkage with the Danish National Patient Register...
August 3, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28771556/common-starlings-sturnus-vulgaris-increasingly-select-for-grazed-areas-with-increasing-distance-to-nest
#18
Henning Heldbjerg, Anthony D Fox, Peder V Thellesen, Lars Dalby, Peter Sunde
The abundant and widespread Common Starling (Sturnus vulgaris) is currently declining across much of Europe due to landscape changes caused by agricultural intensification. The proximate mechanisms causing adverse effects to breeding Starlings are unclear, hampering our ability to implement cost-efficient agri-environmental schemes to restore populations to former levels. This study aimed to show how this central foraging farmland bird uses and selects land cover types in general and how use of foraging habitat changes in relation to distance from the nest...
2017: PloS One
https://www.readbyqxmd.com/read/28767515/35-year-trends-in-first-time-hospitalization-for-hip-fracture-one-year-mortality-and-the-prognostic-impact-of-comorbidity-a-danish-nationwide-cohort-study-1980-2014
#19
Alma B Pedersen, Vera Ehrenstein, Szimonetta Szépligeti, Astrid Lunde, Ylva Trolle Lagerros, Anna Westerlund, Grethe S Tell, Henrik T Sørensen
BACKGROUND: We examined trends in hip fracture incidence in Denmark from 1980 to 2014, trends in subsequent one-year mortality, and the prognostic impact of sex, age, and comorbidity. METHODS: This nationwide cohort study prospectively collected data from population-based Danish registries. We included 262,437 patients with incident hip fracture and assessed comorbidity using the Charlson Comorbidity Index (CCI). RESULTS: Despite slight increases in incidence rates (IRs) of hip fracture up to the mid-1990s, the annual IR decreased by 29% from 1980 to 2014 in women, but remained stable in men...
July 31, 2017: Epidemiology
https://www.readbyqxmd.com/read/28761652/incidence-of-severe-hypoglycemia-in-children-with-type-1-diabetes-in-the-nordic-countries-in-the-period-2008-2012-association-with-hemoglobin-a-1c-and-treatment-modality
#20
N H Birkebaek, A K Drivvoll, K Aakeson, R Bjarnason, A Johansen, U Samuelsson, T Skrivarhaug, A V Thorsson, J Svensson
OBJECTIVE: Treatment of type 1 diabetes has been intensified aiming at normalizing blood glucose, which may increase the risk of severe hypoglycemia (SH). We aimed to compare the incidence of SH events in the four Nordic countries Denmark, Iceland, Norway and Sweden, and to assess the influence of hemoglobin A1c (HbA1c) and treatment modalities on the frequency of SH; particularly, to explore if a HbA1c target ≤6.7% (50 mmol/mol) is feasible. RESEARCH DESIGN AND METHODS: Data on children below 15 years with a diabetes duration more than 1 year, registered in the national childhood diabetes databases in the four Nordic countries from 2008 to 2012, were compiled...
2017: BMJ Open Diabetes Research & Care
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